Abstract

An oven assembly (104) for producing spatially propagating neutral atoms. The oven assembly (104) includes: a first housing (108) configured to house atomic source material (110), at least one passage (134) from an interior of the first housing (108) to an exterior of the first housing (108), a second housing (120), and one or more supports (124). The first housing (108) is held in a fixed position relative to the second housing (120) by the one or more supports (124). The first housing (108), the second housing (120) and the one or more supports (124) are formed from a first homogeneous material.

IPC Classes  ?

• H05H 3/02 - Molecular or atomic-beam generation, e.g. resonant beam generation
• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

The present invention relates to a bacterial process for the production of microbial storage lipids, such as wax esters, triacylclycerides, oils and polyhydroxyalkanoates, from readily available feedstocks derived from biomass. The feedstocks are rich in volatile fatty acids and ammonium, and are generated from biomass via the process of acidogenic fermentation. This allows for the preparation of microbial storage lipids from cheap and readily available biomass sources, such as plant or agricultural waste, or sewage. In particular, the present invention is directed to a process in which the carbon-to-nitrogen ratio of the composition containing volatile fatty acids and ammonium can be effectively controlled so as to optimise the yield of microbial storage lipid production from this process. The present invention also relates to microbial storage lipids that are obtainable by this process, and an apparatus for carrying out the process.

IPC Classes  ?

• C12P 7/62 - Carboxylic acid esters
• C12P 7/625 - Polyesters of hydroxy carboxylic acids
• C12P 7/6409 - Fatty acids

Abstract

Methods and apparatus for obtaining information about entities in a liquid sample are disclosed. In one arrangement, each of a plurality of entities in the liquid sample are caused to complete a predetermined trajectory along a passage containing the liquid sample. The predetermined trajectory of each entity comprises a path through a predetermined sequence of impeding regions defined by respective perturbations defined in or on one or more walls defining the passage. Each perturbation impedes progression of the entity along the predetermined trajectory in a manner that depends on the charge and/or size of the entity. A time taken for each of the entities to complete the predetermined trajectory is measured. The measured times are used to obtain information about the charge and/or size of each of the entities.

IPC Classes  ?

• G01N 15/1429 - Signal processing
• G01N 15/0205 - Investigating particle size or size distribution by optical means
• G01N 15/1031 - Investigating individual particles by measuring electrical or magnetic effects
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry

Abstract

Free space optical communications systems and methods are disclosed. In one arrangement, light is generated for transmission from a first module to a second module. A first polarisation adjuster is controlled to change a polarisation of the generated light and a first polarisation dependent redirector selectively redirects light received from the first polarisation adjuster along one or more of a plurality of available directions as a function of the polarisation of the light. Light received from the first module is redirected at the second module towards a second-module detector.

IPC Classes  ?

• H04B 10/112 - Line-of-sight transmission over an extended range
• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection

Abstract

The invention relates to computer implemented methods for determining the presence or risk of disease and/or vascular state in a subject. The method comprises (a) using data gathered from a computer tomography (CT) scan along a length of two or more blood vessels to determine: (i) a value for the radiodensity and/or one or more radiomic features of the perivascular tissue surrounding each blood vessel or segment thereof; (b) using the value for the radiodensity and/or one or more radiomic features of the perivascular tissue surrounding each blood vessel or segment thereof to determine the presence of disease and/or vascular state in each blood vessel, or segment thereof; and (c) generating an output value based on the number of vessels or segments thereof with disease and/or vascular state that indicates the subject's presence or risk of disease and/or vascular state. The invention also relates to computer program products, systems and machine learning or statistical modeals for performing the methods of the invention. Also disclosed is methods of training said machine learning or statistical models, and related systems.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

The invention relates to antibodies which are capable of specifically binding to TCRbeta1 or TCRbeta2, and associated uses in diagnosis, prognosing and treatment of a disease or disorder associated with T-cell monotypia, or T cell-associated inflammation.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 35/00 - Antineoplastic agents
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61P 37/00 - Drugs for immunological or allergic disorders

Abstract

The invention relates to modulating the function of a regulatory element in a nucleic acid, comprising delivering to a cell a catalytically inactive Cas13 (dCas13) protein and a CRISPR RNA (crRNA), wherein the crRNA recruits the dCas13 protein to the regulatory element, such that the dCas13 protein sterically blocks the regulatory element.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors

Abstract

The present invention relates to a process for the catalytic decomposition of a polyolefin. More particularly, the present invention relates to the aromatic-aided catalytic decomposition of polyolefins under mild conditions using a zeolite.

IPC Classes  ?

• C07C 4/22 - Preparation of hydrocarbons from hydrocarbons containing a larger number of carbon atoms by depolymerisation to the original monomer, e.g. dicyclopentadiene to cyclopentadiene
• B01J 29/40 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
• B01J 35/61 - Surface area
• B01J 35/64 - Pore diameter
• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material

Abstract

The present invention relates to a culture medium comprising low glucose DMEM, L- glutamine, foetal bovine serum (FBS), antimicrobials and a trypsin inhibitor; the use of said culture medium for culturing mammalian cells and/or maintaining the viability of live tissue or tumour slices, optionally in a perfusion model; a method for 5 identifying a treatment for cancer utilising said culture medium; and a method for perfusion cell culture utilising said culture medium.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/09 - Tumour cells
• G01N 33/483 - Physical analysis of biological material
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

New block polymers are described, as well as processes for preparing them using ring-opening polymerisation and ring-opening copolymerisation techniques. Also described are electrolytes, cathodes and batteries comprising the polymers.

IPC Classes  ?

• C08G 64/18 - Block or graft polymers
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type

Abstract

The present invention relates to fusion polypeptides and particles, particularly virus-like particles (VLPs), comprising selected repeat units derived from the repeating regions of Type I and Type II circumsporozoite proteins (CSPs) of Plasmodium vivax (Pv), together with an amino acid sequence derived from the Hepatitis B virus surface antigen. The invention also relates to nucleotide sequences coding for such fusion polypeptides, vectors and plasmids comprising such nucleotide sequences, and host cells comprising such vectors and plasmids. The invention additionally relates to compositions, particularly vaccine compositions, comprising the fusion polypeptides or VLPs for use in the prevention of malaria.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61P 33/06 - Antimalarials

Abstract

This disclosure relates to GC-globulin or a variant thereof and a GLP1RA or a pharmaceutically acceptable salt thereof, for use in treating or preventing one or more of diabetes, obesity, MASLD and neurodegeneration.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/26 - Glucagons
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 5/50 - Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The invention relates to an antibody or antigen binding fragment thereof which is capable of binding to CD1a. The antibody or antigen binding fragment thereof may be chimeric or humanised, and may be used to treat one or more inflammatory skin or mucosal disorder, or disease or one or more associated systemic disease or disorder, or one or more inflammatory drug reaction which manifests systemically, or a CD1a-expressing malignancy.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A catalyst precursor comprising an iron species, an alkali metal or salt thereof and a complexing agent, a catalyst obtainable from said precursor, and a process for the hydrogenation of carbon dioxide and/or carbon monoxide using either said catalyst precursor or said catalyst to yield olefins or fuels, such as jet fuel.

IPC Classes  ?

• B01J 23/889 - Manganese, technetium or rhenium
• B01J 35/30 - Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
• B01J 37/08 - Heat treatment
• C10G 2/00 - Production of liquid hydrocarbon mixtures of undefined composition from oxides of carbon

Abstract

Laser processing methods and apparatus are disclosed. In one arrangement, a method comprises using a laser beam to modify a sample along a processing trajectory in the sample by focusing the laser beam through a first face of the sample to a laser focus in the sample and providing relative movement between the laser focus and the sample to move the laser focus along the processing trajectory. The processing trajectory comprises a proximal portion and a distal portion. The proximal portion is nearer to a second face of the sample than the distal portion. The method comprises interacting with or adjusting the laser beam during processing of the proximal portion to reduce or prevent impingement of the laser beam onto the second face during the processing of the proximal portion.

IPC Classes  ?

• B23K 26/066 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms by using masks
• B23K 26/53 - Working by transmitting the laser beam through or within the workpiece for modifying or reforming the material inside the workpiece, e.g. for producing break initiation cracks
• B23K 103/00 - Materials to be soldered, welded or cut

Abstract

The invention relates to agents specific for a heterocomplex comprising CD61 and CD103, and methods and uses of such agents.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells

Abstract

The invention relates to an electromicrobial system for synthesis of hydrogen, comprising: a gram-negative bacterial cell modified for synthesis of hydrogen, wherein the bacterial cell comprises: i) inner membrane-bound rhodopsin for proton-pumping, ii) membrane-bound hydrogenase, and iii) optionally an electron mediator located in the periplasm and/or on the outer membrane of the bacterial cell; and an electron source for donation of electrons to the bacterial cell.

IPC Classes  ?

• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
• C07K 14/80 - Cytochromes
• C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/10 - Transferases (2.)
• C12N 9/90 - Isomerases (5.)
• C12N 15/52 - Genes encoding for enzymes or proenzymes

Abstract

A negative electrode for a solid-state battery, the negative electrode having a first surface and thickness, the negative electrode for a solid-state battery comprising: a first phase including a first metallic element; a second phase distributed in the first phase, wherein the second phase is an intermetallic phase including the first metallic element and at least a second element, and wherein a diffusion coefficient of the first metallic element in the second phase is greater than a diffusion coefficient of the first metallic element in the first phase, and wherein there are a plurality of continuous pathways of the second phase each through at least half the thickness of the negative electrode.

IPC Classes  ?

• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/052 - Li-accumulators
• H01M 10/0562 - Solid materials
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

A circuit quantum electrodynamics, QED, component having a geometrical arrangement based on a geometrically symmetric arrangement that enables the formation of degenerate modes in a circuit QED device, wherein the geometrical arrangement comprises a symmetry breaking perturbation relative to the geometrically symmetric arrangement such that the component is configured to generate one or more engineered interference effects and/or additional functionality in the circuit QED device.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• H10N 60/80 - Constructional details
• H10N 69/00 - Integrated devices, or assemblies of multiple devices, comprising at least one superconducting element covered by group

Abstract

A time-varying array of controllable elements configured to receive an input signal in the form of electromagnetic radiation impinging on the array, wherein: each controllable element is configured to have a non-linear response to the input signal; and at least a subset of the controllable elements is configured to: adjust a permeability response of the array; and modulate an input signal receivable at the array based on the adjusted permeability response in order selectively to generate one or more output signals in a range of one or more corresponding target directions, each output signal comprising electromagnetic radiation.

IPC Classes  ?

• H01Q 15/00 - Devices for reflection, refraction, diffraction or polarisation of waves radiated from an antenna, e.g. quasi-optical devices
• H01Q 25/00 - Antennas or antenna systems providing at least two radiating patterns

Abstract

A method to determine the amount of carbonate in a biomineralized CaCO3 particle is described, the method involving electrochemically generating a controlled amount of acid at an electrode in a carrier liquid which also contains the biomineralized CaCO3 particle such that the acid diffuses from the electrode and then reacts with the biomineralized CaCO3 particle, such that it starts to dissolve, and, monitoring the dissolution of the biomineralized CaCO3 particle until it has completely dissolved to determine the amount of carbonate in the biomineralized CaCO3 particle. An apparatus that is configured to carry out the method is also described.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle

Abstract

Provided is a chimaeric protein comprising a ubiquitin ligase domain and a RAS-specific endogenous targeting portion. The ubiquitin ligase domain may be a VHL E3 ligase domain, or a fragment or variant thereof having ubiquitin ligase activity; or a UBOX domain of CHIP, or a fragment or variant thereof having ubiquitin ligase activity. The RAS-specific endogenous targeting portion may be a RAS-specific DARPin; or a RAS-specific intracellular antibody. In particular, the RAS-specific endogenous targeting portion may be a KRAS-specific endogenous targeting portion (for example a KRAS-specific DARPin, or a KRAS-specific intracellular antibody). The chimaeric proteins may be used in the prevention and/or treatment of a RAS-associated disorder, such as a RAS-associated cancer or a RASopathy. Further provided is a chimaeric protein comprising a ubiquitin ligase domain and an LMO2-specific endogenous targeting portion.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 35/00 - Antineoplastic agents
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

According to various examples of the present disclosure, there is provided a machine learning image segmentation model for automatically identifying and segmenting structural features of a vessel tree from image frames. The model comprises a 3D encoder and 2D decoder, the 3D encoder and 2D decoder connected by at least one interlinked convolution node and a plurality of temporal extraction nodes therebetween. The model is configured to identify and segment structural features of a vessel tree from the plurality of image frames, by the model being configured to: receive a plurality of image frames as an input to the 3D encoder; provide an output of the 3D encoder as an input to the plurality of temporal extraction nodes to extract temporal information; generate, by the plurality of temporal extraction nodes, a 2D temporal output based on the extracted temporal information; provide the generated 2D temporal output to the at least one interlinked 2D convolution node and 2D decoder; generate, at the 2D decoder, a combined temporal output based on an output of the at least one interlinked 2D convolution node and at least one temporal extraction node, wherein the combined temporal output represents a predicted segmentation of the vessel; and generate an output representative of the segmented structural features of the vessel tree based on the predicted segmentation.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation
• G06T 7/174 - SegmentationEdge detection involving the use of two or more images

Abstract

The present invention relates to the generation of organoids using granular hydrogel, which is a compacted assembly of hydrogel microparticles.

IPC Classes  ?

• C12N 5/078 - Cells from blood or from the immune system
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

Apparatus and methods for performing ex-vivo perfusion of an organ are disclosed. In one arrangement, an organ receiving unit (4) receives an ex-vivo organ and provides fluidic connections to a vasculature of the received organ. A first conduit system defines a perfusate flow circuit (21) including a flow path through the vasculature of the received organ. A perfusate pumping system (14) drives a circulatory flow of perfusate in the perfusate flow circuit and through the vasculature of the received organ. A second conduit system defines a dialysate flow circuit (22). A dialysate pumping system drives a circulatory flow of a dialysate in the dialysate flow circuit. A dialysis unit processes the perfusate using the dialysate, the dialysis unit comprising a membrane configured to contact the perfusate in the perfusate flow circuit on one side of the membrane and the dialysate in the dialysate flow circuit on the other side of the membrane. The membrane allows material to pass between the perfusate flow circuit and the dialysate flow circuit as a transmembrane flux.

IPC Classes  ?

• A01N 1/143 - Apparatus for organ perfusion
• A01N 1/144 - Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus

Abstract

A large language model system is disclosed. In one arrangement the system comprises: a data processing system configured to implement a first large language model, a second large language model, and a third large language model, wherein the data processing system is configured to: receive inquiry data representing a user inquiry; input at least the inquiry data to the first large language model and receive a first data output as a corresponding output from the first large language model; input at least the first data output and a knowledge graph to the second large language model and receive a second data output as a corresponding output from the second large language model; input at least the first data output, the second data output, and the inquiry data to the third large language model and receive a third data output as a corresponding output from the third large language model; and output the third data output as an answer to the user inquiry.

IPC Classes  ?

• G06F 16/3329 - Natural language query formulation
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Method of laser modifying an optical fibre to form a modified region at a target location within the fibre, comprising positioning at least a portion of an optical fibre in a laser system for modification by a laser, applying a correction to an active optical element of the laser system to modify wavefront properties of the laser to counteract an effect of aberration on laser focus, and laser modifying the optical fibre at the target location using the laser with the corrected wavefront properties to produce the modified region.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding

Abstract

The present invention relates to polypeptides for treatment or prevention of malaria.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens

Abstract

The present invention relates to a technique for continuous sensing of particles, such as ions, under flow. The technique involves the use of continuous and polarisation-tuned redox capacitive sensing at suitably designed electroactive interfaces.

IPC Classes  ?

• G01N 27/327 - Biochemical electrodes
• G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance

Abstract

A method of forming a device comprising: providing a device substrate; providing a flexible multilayer substrate having an insulating layer and an electrically conductive layer formed on the insulating layer; forming a patterned layer on a surface of the electrically conductive layer, thereby to provide protected and unprotected regions of the electrically conductive layer; etching the unprotected regions of the electrically conductive layer, thereby to form one or more electrically conductive features on the insulating layer of the flexible multilayer substrate; removing the patterned layer; and conformally applying the one or more electrically conductive features formed on the insulating layer of the flexible multilayer substrate to a target surface of the device substrate.

IPC Classes  ?

• H03H 3/08 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of resonators or networks using surface acoustic waves
• H03H 3/06 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of magnetostrictive resonators or networks
• H03H 9/05 - Holders or supports
• H03H 9/08 - Holders with means for regulating temperature

Abstract

A method of correcting for an aberration in an optical system (600) comprising an imaging detector (634) having a focussing lens (608) and a spatial light modulator (610) is provided. The method comprises receiving an image. The method comprises determining an intensity aberration compensation from the collected image. The method comprises controlling the spatial light modulator (610) to reduce the intensity aberration by applying the intensity aberration compensation.

IPC Classes  ?

• G02B 26/06 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

Methods and apparatus for determining a control sequence for execution on a quantum computer and for determining a sequence of pulses of radiation. The method includes receiving a target quantum operation, determining a circuit or pulse library comprising a plurality of quantum circuits or pulses, each of which approximate the target operation, determining a solution weight vector which synthesises the target operation when applied in a weighted summation over the circuit or pulse library and which satisfies a minimum condition, determining a probability associated with each quantum circuit or pulse in the library, and performing a plurality of selections of a quantum circuit or pulse from the library according to the probability distribution to form a control sequence or sequence of pulses.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

Methods of obtaining information about entities in a liquid sample are disclosed. An observation volume is defined by a pair of confinement surfaces of a reservoir containing a sample. The confinement surfaces define a plurality of traps. Information about residence times of target entities in the traps is obtained and used to determine information about the target entities. A ratio of an average separation between the confinement surfaces outside of the traps and a maximum dimension of each target entity is equal to or less than 50.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution
• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials

Abstract

A method for controlling an aerial vehicle, UAV, includes causing the UAV to adjust its orientation; monitoring a change in radio signal received at the UAV with the change in orientation; determining a translational movement of the UAV based on the monitored change; and causing translational movement of the UAV based on the determination.

IPC Classes  ?

• G01S 13/75 - Systems using reradiation of radio waves, e.g. secondary radar systemsAnalogous systems using transponders powered from received waves, e.g. using passive transponders
• G05D 1/242 - Means based on the reflection of waves generated by the vehicle
• G05D 1/689 - Pointing payloads towards fixed or moving targets
• G05D 105/80 - Specific applications of the controlled vehicles for information gathering, e.g. for academic research
• G05D 109/20 - Aircraft, e.g. drones

Abstract

Disclosed herein is an in-situ leaching system comprising: a lixiviant source; and an injection well arranged to receive a leaching solution at ground level and to inject the received leaching solution into underground glassy volcanic rock; wherein: the leaching solution comprises lixiviant from the lixiviant source; and the leaching solution is for leaching the underground glassy volcanic rock.

IPC Classes  ?

• B01D 11/02 - Solvent extraction of solids
• C22B 3/02 - Apparatus therefor
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C22B 3/08 - Sulfuric acid
• C22B 3/12 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic alkaline solutions
• C22B 3/20 - Treatment or purification of solutions, e.g. obtained by leaching
• C22B 19/00 - Obtaining zinc or zinc oxide
• C22B 34/14 - Obtaining zirconium or hafnium
• C22B 34/24 - Obtaining niobium or tantalum
• C22B 59/00 - Obtaining rare earth metals
• E21B 34/16 - Control means therefor being outside the borehole
• E21B 43/12 - Methods or apparatus for controlling the flow of the obtained fluid to or in wells
• E21B 43/28 - Dissolving minerals other than hydrocarbons, e.g. by an alkaline or acid leaching agent
• F24T 10/20 - Geothermal collectors using underground water as working fluidGeothermal collectors using working fluid injected directly into the ground, e.g. using injection wells and recovery wells
• F24T 10/30 - Geothermal collectors using underground reservoirs for accumulating working fluids or intermediate fluids
• F24T 50/00 - Geothermal systems
• F24V 99/00 - Subject matter not provided for in other main groups of this subclass
• E21B 43/29 - Obtaining a slurry of minerals, e.g. by using nozzles
• F24T 10/00 - Geothermal collectors

Abstract

This invention relates to a panel for an X-ray detector comprising a bismuth oxyiodide (BiOI) single crystal material, or a material derived therefrom, as well as a bismuth oxyiodide single crystal material useful in such an X-ray detector, as well as a method for preparing the same. In one aspect, the present invention provides a bismuth oxyiodide (BiOI) single crystal material for use in a panel for an X-ray detector having a length (L) dimension of at least 1 mm, a width (W) dimension of at least 1 mm, and a thickness (T) dimension of at least 0.12 mm.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• C01G 29/00 - Compounds of bismuth
• C30B 29/12 - Halides

Abstract

The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

IPC Classes  ?

• G01N 21/49 - Scattering, i.e. diffuse reflection within a body or fluid
• G01N 15/0205 - Investigating particle size or size distribution by optical means
• G01N 15/06 - Investigating concentration of particle suspensions
• G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

Immunogenic compositions and methods of their use in eliciting immune responses to coronaviruses, such as SARS-CoV-2 are provided.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 9/51 - Nanocapsules
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/14 - Hydrolases (3.)
• C12N 15/86 - Viral vectors
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The invention relates to a composition comprising a polypeptide comprising, or consisting of, the amino acid sequence of SEQ ID) NO: 1, or a sequence having at least 80%, 85%, 90%, 95%, 98%, or 99% sequence identity to SEQ ID NO: 1 (R21), wherein said polypeptide is in the form of a virus-like particle (VLP), wherein said particle comprises less than 10% free hepatitis B surface antigen protein, for use in the immunisation of a human subject susceptible to Plasmodium falciparum infection, characterised in that said composition is administered in a dosage regimen of at least one dose of 1 μg to 20 μg R21 per administration for a subject at least 18 years old, or at least one dose of 0.5 μg to 10 μg R21 per administration for a subject less than 18 years old. The invention also relates to kits, methods and uses.

IPC Classes  ?

• C07K 14/02 - Hepadnaviridae, e.g. hepatitis B virus
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 39/29 - Hepatitis virus
• C07K 14/445 - Plasmodium

Abstract

The disclosure relates to methods of manufacturing a composite object. A disclosed method comprises positioning a stack (2) of layers against a non-planar moulding surface (4) of a moulding device and curing the stack of layers to form a composite object (8). Before the curing, the stack comprises a set of fibre-matrix layers (21) and a set of isotropic layers (22).

IPC Classes  ?

• B29C 70/08 - Fibrous reinforcements only comprising combinations of different forms of fibrous reinforcements incorporated in matrix material, forming one or more layers, with or without non-reinforced layers
• B29C 70/88 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts characterised primarily by possessing specific properties, e.g. electrically conductive or locally reinforced
• B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
• B32B 27/28 - Layered products essentially comprising synthetic resin comprising copolymers of synthetic resins not wholly covered by any one of the following subgroups
• B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
• B32B 1/08 - Tubular products
• B32B 15/20 - Layered products essentially comprising metal comprising aluminium or copper
• B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• H05H 7/00 - Details of devices of the types covered by groups
• H05H 7/14 - Vacuum chambers

Abstract

The present disclosure relates to methods of operating a parametric amplifier. In one arrangement, a parametric amplifier is provided that comprises a nanostructure suspended between an input electrode and an output electrode. The nanostructure is spaced apart from a control electrode and configured such that a vibration of the nanostructure varies a distance between at least a portion of the nanostructure and the control electrode. A single-electron transistor is formed that comprises the nanostructure as a conducting island of the single-electron transistor. An oscillatory input signal is applied to the input electrode. An oscillatory control signal is applied to the control electrode. The control signal comprises a DC component that defines a potential of the island and an electrostatic tensioning of the nanostructure and an oscillatory pump component that provides an amplified version of the input signal in an output signal provided at the output electrode.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The invention provides means and methods for administering agents, including therapeutic agents, to the retina of a subject The methods comprise injecting the agent directly into the optic nerve.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61F 9/007 - Methods or devices for eye surgery

Abstract

The present invention relates to methods for increasing dopamine levels in a subject. The present invention also relates to the treatment of condition or disorder in which reduced levels of dopamine are implicated, and agents for use in such treatments.

IPC Classes  ?

• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/13 - Amines, e.g. amantadine
• A61P 25/16 - Anti-Parkinson drugs

Abstract

An acoustic reactor is provided, comprising a body defining a chamber for holding an ultrasound medium and a reactor vessel for receiving a reactant, the reactor vessel positioned in the chamber. An ultrasound transducer arrangement is configured to emit coherent ultrasound waves into the chamber. A reflector arrangement is arranged to reflect coherent ultrasound waves from the ultrasound transducer arrangement in opposing directions into the reactor vessel so as to form a standing wave in the reactor vessel.

IPC Classes  ?

• B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus

Abstract

The invention relates to methods for detecting chimeric artefact polynucleotides produced during amplification of a mixed sample of polynucleotide. The methods comprise adding identifier sequences to both ends of a sample polynucleotide. Also provided are arrays of annealed oligonucleotide strand pairs for providing a mixed pool of identifier sequences; kits and methods for producing a library of polynucleotides, or libraries of polynucleotides having identifier sequences at both ends of the polynucleotides; and arrays of template switch oligonucleotides.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

Provided herein are methods for moving molecular hoppers along tracks; methods of characterising an analyte using molecular hoppers; kits for characterising an analyte; and molecule hoppers per se and systems comprising such hoppers. The invention particularly relates to the use of such methods and kits in the characterisation of analytes.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• C12Q 1/6869 - Methods for sequencing
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule, wherein the peptides comprise at least two cationic domains each comprising a plurality of lysine residues and wherein the peptides do not contain arginine residues. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular neuromuscular diseases.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• C07K 19/00 - Hybrid peptides

Abstract

The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

Provided is a method of optical modulation including using a control optical signal to modulate a controlled optical signal. The controlled optical signal propagates in an optical medium of an optical transmission structure. The control optical signal modulates the controlled optical signal by being at least partially absorbed in the optical transmission structure and thereby changing an optical property of the optical medium. Also provided is an optical modulation element including an optical transmission structure and a controller, the optical modulation element configured to carry out the method and use a control optical signal to modulate a controlled optical signal.

IPC Classes  ?

• G02F 1/35 - Non-linear optics
• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means

Abstract

The invention relates to polynucleotides comprising sequences that flank variable regions, such as barcode sequences (BCs) and unique molecular identifier sequences (UMIs). The invention also relates to methods of delimiting the BC and/or the UMI in sequencing reads of said polynucleotides.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

New block polymers are described, as well as processes for preparing them using a ring-opening copolymerisation technique. Also described are electrolytes, cathodes and batteries comprising the polymers.

IPC Classes  ?

• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/137 - Electrodes based on electro-active polymers
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds

Abstract

A method for training a machine learning image segmentation algorithm to segment structural features of a blood vessel in a computed tomography (CT) image is described herein. The method comprises receiving a labelled training set for the machine learning image segmentation algorithm. The labelled training set comprising a plurality of CT images, each CT image of the plurality of CT images showing a targeted region of a subject, the targeted region including at least one blood vessel. The labelled training set further comprises a corresponding plurality of segmentation masks, each segmentation mask labelling at least one structural feature of a blood vessel in a corresponding CT image of the plurality of CT images. The method further comprises training a machine learning image segmentation algorithm, using the plurality of NCT images and the corresponding plurality of segmentation masks, to learn features of the CT images that correspond to structural features of the blood vessels labelled in the segmentation masks, and output a trained image segmentation model. The method further comprises outputting the trained image segmentation model usable for segmenting structural features of a blood vessel in a CT image. Further methods are described herein for using the trained image segmentation model to segment structural features of blood vessels, and to establish the training set for training the machine learning image segmentation model. Computing apparatuses and computer readable media are also described herein.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation
• G06T 7/00 - Image analysis
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Abstract

in vivoin vivo. The invention also relates to coatings comprising an amino-functionalised graphene oxide; devices coated in an amino-functionalised graphene oxide; coating solutions; methods of coating a device; and an amino-functionalised graphene oxide.

IPC Classes  ?

• A61K 33/44 - Elemental carbon, e.g. charcoal, carbon black
• A61L 31/00 - Materials for other surgical articles
• C08K 3/04 - Carbon

Abstract

Methods and apparatus for training a neural network are disclosed. In one arrangement, a method comprises performing forward propagation of information through the neural network. An error backpropagation is performed to update parameters defining the neural network. A mathematically linear stage of the forward propagation is performed optically.

IPC Classes  ?

• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means
• G06N 3/048 - Activation functions
• G06N 3/084 - Backpropagation, e.g. using gradient descent

Abstract

22, which may be further processed to MgO for use as an additive in green cement. As part of the process, the pH of seawater is adjusted to pH 9.0- 10.5 (e.g., pH 9.5-10.5) in order to precipitate dissolved inorganic carbon, after which the resulting low carbon seawater is subjected to a reverse osmosis process. The pH of the permeated brine is then adjusted to pH 10.0-13.25 (e.g., pH 11.5-13.25) in order to precipitate Mg2+222 and/or to produce NaOH, which can be advantageously used in the aforementioned precipitation steps.

IPC Classes  ?

• C02F 9/00 - Multistage treatment of water, waste water or sewage
• C01F 5/14 - Magnesium hydroxide
• B01D 61/02 - Reverse osmosisHyperfiltration
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 1/52 - Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities
• C02F 1/66 - Treatment of water, waste water, or sewage by neutralisationTreatment of water, waste water, or sewage pH adjustment
• C02F 103/08 - Seawater, e.g. for desalination

Abstract

An electrochemical battery, comprising a sulphur cathode; a lithium anode; and a solid electrolyte between the sulphur cathode and the lithium anode, wherein the solid electrolyte has an argyrodite-type structure and comprises lithium, phosphorus, sulphur, and a halogen.

IPC Classes  ?

• H01M 4/136 - Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 10/052 - Li-accumulators
• H01M 10/0562 - Solid materials
• C01B 25/14 - Sulfur, selenium, or tellurium compounds of phosphorus
• C01D 15/04 - Halides

Abstract

abcc wherein: [A] comprises one or more A cations; [M] comprises one or more M cations which are metal or metalloid cations; [X] comprises one or more X anions; a is a number from 1 to 6; b is a number from 1 to 6; and c is a number from 1 to 18, and wherein the passivating agent comprises an organic compound, wherein the organic compound comprises a silane moiety and (a) does not comprise an amine moiety, or (b) comprises an amine moiety which is a secondary amine, a tertiary amine or a quaternary amine, or the passivating agent comprises a dimer or a polymer of the organic compound. The invention also provides the use of the above-defined passivated A/M/X material as a sensitizer in a photovoltaic device. The present invention also relates to processes for producing a passivated A/M/X material and then (a) producing a photovoltaic device comprising the passivated A/M/X material or (b) using the passivated A/M/X material as a sensitizer in a photovoltaic device.

IPC Classes  ?

• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers

Abstract

Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• C07K 19/00 - Hybrid peptides
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The invention relates to methods for diagnosing inflammatory bowel disease (IBD) and for distinguishing between common gastrointestinal disease (principally functional bowel disease/irritable bowel syndrome and coeliac disease) and IBD, especially in children and in subjects with normal levels of C-reactive protein. The methods are based on measuring the methylation level of at least one CpG site in at least one gene.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention relates to identifying one or more anomalous monomers in a polymer. This invention also relates to a method of preparing control data for use in a method of identifying anomalous monomers in a polymer. The invention also relates to an apparatus to perform the method and a system comprising this apparatus and a nucleic acid sequencer.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• C12Q 1/6869 - Methods for sequencing
• G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
• G16B 40/20 - Supervised data analysis

Abstract

The present invention relates to processes for the oxidation of sesquiterpenes comprising fused 5- and 7-membered rings using mutant Cytochrome P450 family 102A sub-family member (CYP102A) enzymes. The invention also relates to mutant CYP102A enzymes, polynucleotides encoding the enzymes, cells expressing the enzymes, transgenic animals or plants comprising the enzymes, and compounds produced by the processes.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C07C 13/32 - Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings

Abstract

The present invention relates to methods comprising exposure of a rotifer to a microbe. The invention also relates to compounds, polynucleotides, methods of therapy and methods of controlling microbial disease in plants.

IPC Classes  ?

• A01P 3/00 - Fungicides
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 7/66 - Gramicidins S, CTyrocidins A, B, CRelated peptides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

Compounds I suitable for use in sensing anions, such as sulphide are described. Also described is a method of detecting sulphide using the described compounds. Compounds I suitable for use in sensing anions, such as sulphide are described. Also described is a method of detecting sulphide using the described compounds.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07F 5/02 - Boron compounds
• G01N 33/18 - Water

Abstract

An electrode material for a solid-state battery is described. The electrode material comprises an alloy comprising lithium and magnesium, wherein the alloy has a total amount of magnesium of less than 5.0 at.%. An electrode, a solid-state battery, uses of the electrode material or the electrode and a method of producing an electrode material or an electrode are also described.

IPC Classes  ?

• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/66 - Selection of materials
• H01M 10/0562 - Solid materials

Abstract

P_AP_AP_BP_BP_CP_CP_AP_BP_CP_AP_CP_C having a second, arbitrary polarisation.

IPC Classes  ?

• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

An ultrasound beam shaping device, and method of designing an ultrasound beam shaping device are disclosed. The beam shaping device comprises an array of waveguides formed in a structure that is capable of reflecting ultrasound. The lengths and cross-sections of the waveguides of the array are selected based on a desired shape of the ultrasound beam at a target, such that the amplitude and phase of the ultrasound emitted from the waveguides of the array provides the desired shape of the ultrasound beam at the target.

IPC Classes  ?

• A61N 7/00 - Ultrasound therapy
• B06B 1/04 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with electromagnetism

Abstract

xyz22 (1) wherein M is a transition metal selected from manganese, nickel, iron, titanium, copper and a combination of two or more thereof; and x, y and z satisfy the following relationships: (i) 0.5 ≤ x ≤ 1.0; (ii) 0.01 ≤ y ≤ 0.25; and (iii) y + z = 1.0. Also described is a positive electrode material, a positive electrode and a device.

IPC Classes  ?

• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• C01G 53/51 - Complex oxides containing nickel and at least one other metal element containing alkali metals, e.g. LiNiO2 containing manganese of the type (MnO2)n-, e.g. Li(NixMn1-x)O2 or Li(MyNixMn1-x-y)O2 containing sodium

Abstract

The invention relates to methods of treating, diagnosing or preventing TDP-43 proteinopathies, selecting patients with TDP-43 proteinopathies for treatment, and agents for use in such methods, wherein the agents modulate ATG4B expression or activity.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to antibodies capable of binding to the spike protein of coronavirus SARS-CoV-2, and methods and uses thereof in the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses

Abstract

The present invention relates to a two-part linker comprising a peptide (peptide tag) and a polypeptide (protein) that is capable of spontaneously forming an isopeptide bond, particularly in low temperature and low pH conditions. Recombinant or synthetic polypeptides comprising the polypeptide or peptide tag, nucleic acid molecules encoding the polypeptide, peptide tag or recombinant polypeptides, vectors comprising said nucleic acid molecules, and host cells comprising said vectors and nucleic acid molecules are provided herein. A kit and apparatus comprising said polypeptide and peptide tag and various methods and uses of the polypeptide and peptide tag are also provided.

IPC Classes  ?

• C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof

Abstract

The present invention relates to a cosmetic composition (e.g. sunscreen composition), and to a method for making the cosmetic composition.

IPC Classes  ?

• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• A61K 8/26 - AluminiumCompounds thereof
• A61K 8/27 - ZincCompounds thereof
• A61K 8/29 - TitaniumCompounds thereof
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations

Abstract

A method of determining aberration in an optical system comprising an adaptive optical element is provided. The method comprises obtaining a first image in which the adaptive optical element is in a first configuration. The method comprises obtaining a second image in which the adaptive optical element is in a second configuration, wherein the second configuration is different from the first configuration. The method comprises applying a transform to the first image and the second image to produce a transformed first image and a transformed second image. The method comprises obtaining a ratio comprising the transformed first image and the transformed second image and determining a pseudo-PSF from the ratio. The method comprises providing data sampled from the pseudo-PSF to a machine learning algorithm that has been trained to determine an output indicative of aberration coefficients from the data.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

Probes and systems for measuring flow are provided. In one arrangement, a pitot tube extends parallel to a probe axis and defines a first probe opening at a distal end. A shroud extends axially beyond the distal end to inhibit oblique flow into the first probe opening. The shroud defines a flow passage between the shroud and the pitot tube. The shroud comprises a distal surface defining one or more second probe openings. The distal surface has an outer portion facing at least partly in a radially outward direction. The one or more second probe openings are at least partially defined in the outer portion.

IPC Classes  ?

• G01P 5/165 - Arrangements or constructions of Pitot tubes
• B64D 43/02 - Arrangements or adaptations of instruments for indicating aircraft speed or stalling conditions
• G01F 1/46 - Pitot tubes

Abstract

The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/12 - Viral antigens
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• C08F 220/54 - Amides
• C08F 220/56 - AcrylamideMethacrylamide
• C08F 220/60 - Amides containing nitrogen in addition to the carbonamido nitrogen

Abstract

A component mounting assembly for mounting a component in a mount structure, the mounting assembly comprising a support body arranged to be connected to the component or to the mount structure; an even number N of beams, N being at least four, wherein said beams are arranged in a loop either outside the support body in the case that the support body is arranged to be connected to the component; or inside the support body in the case that the support body is arranged to be connected to the mount structure; wherein adjacent beams in the loop are connected by respective hinge joints that permit relative rotation of the adjacent beams connected thereby, the beams being integrally formed with each other and the hinge joints being integral connections having a compliance that permits said relative rotation of the adjacent beams connected thereby; wherein each beam is connected to the support body by a respective pivot joint that permit relative rotation of the respective beam and the support body, the beams and the support body being integrally formed, and the pivot joints being integral connections having a compliance that permits said relative rotation of the respective beam and support body; wherein a plurality of said beams comprise contact surfaces arranged to contact either an internal surface of the mount structure in the case that the support body is arranged to be connected to the component; or an external surface of the component the in the case that the support body is arranged to be connected to the mount structure, such that the contact surfaces provide a reaction force to the beams on which they are provided that induces relative rotation of adjacent beams in alternate rotational directions at successive pivot joints around the loop, to thereby align the component relative to the mount structure.

IPC Classes  ?

• G02B 7/00 - Mountings, adjusting means, or light-tight connections, for optical elements

Abstract

An ion trap assembly comprising an ion trap body, a component, and a compliant structure, wherein the compliant structure is a passive alignment structure configured to positionally retain the component relative to the body. In one embodiment, a cantilever beam positionally retains an optical fibre component relative to a groove. This avoids the drawbacks of gluing optical components.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

Examples disclosed herein provide computer-implemented methods and apparatus of generating a realistic front view, FV, of an environment. A method comprises: receiving, as input, a latent floorplan indicative of an environment, the latent floor plan representational of a semantic birds-eye-view, BEV, of the environment; obtaining a volumetric representation of the environment based on the latent floorplan using a neural radiance field, NeRF; obtaining a semantic FV of the environment by volume rendering based on the volumetric representation of the environment; obtaining a realistic FV of the environment based on the semantic FV using a diffusion technique; and outputting the realistic FV of the environment.

IPC Classes  ?

• G06T 15/20 - Perspective computation
• G06T 17/00 - 3D modelling for computer graphics
• G06T 15/08 - Volume rendering

Abstract

An interferometric scattering microscope is adapted by performing spatial filtering of output light, which comprises both light scattered from a sample location and illuminating light reflected from the sample location, prior to detection of the output light. The spatial filtering passes the reflected illumination light but with a reduction in intensity that is greater within a predetermined numerical aperture than at larger numerical apertures. This enhances the imaging contrast for coherent illumination, particularly for objects that are weak scatterers.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01G 9/00 - Methods of, or apparatus for, the determination of weight, not provided for in groups
• G01N 15/1434 - Optical arrangements
• G02B 21/08 - Condensers
• G02B 21/14 - Condensers affording illumination for phase-contrast observation
• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

The present invention relates to a process for the catalytic decomposition of a polyolefin. More particularly, the present invention relates hydrocarbon-aided catalytic decomposition of a polyolefin using an aluminosilicate.

IPC Classes  ?

• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material

Abstract

P360293WO 44 Abstract Provided is a compound of formula (I) or a pharmaceutically acceptable salt, solvate and/or hydrate thereof which can be used as a radiopharmaceutical agent for the imaging and/or treatment of diseases. Also provided are conjugates of the compound of formula (I) with radionuclides and uses of the conjugates and compositions comprising the conjugates for 5 the imaging and/or treatment of diseases. (I) [Figure 1]

IPC Classes  ?

• C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• A61P 35/00 - Antineoplastic agents
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Abstract

The present invention relates to novel compounds and methods. The invention particularly provides a compound that finds use in the treatment of cancer by selectively degrading under hypoxic conditions a therapeutic target protein of interest. The compound is a hypoxia-activated proteolysis targeting chimera (hypoxia-activated PROTAC; HAP-TAC).

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• C07D 495/14 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to antibodies for treatment or prevention of malaria.

IPC Classes  ?

• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• A61P 33/06 - Antimalarials

Abstract

The invention relates to a power unit comprising a series of droplets, a method of producing such a power unit, a method of activating such a power unit, an active power unit obtainable from the power unit, a device comprising the power unit or active power unit, a method of generating electric current using the power unit or active power unit, and method of modulating the activities of one or more cells or tissues using the power unit or active power unit.

IPC Classes  ?

• H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen
• H01M 6/26 - Cells without oxidising active material, e.g. Volta cells
• H01M 10/02 - Details
• H01M 10/04 - Construction or manufacture in general
• H01M 10/36 - Accumulators not provided for in groups
• H01M 10/38 - Construction or manufacture
• H01M 14/00 - Electrochemical current or voltage generators not provided for in groups Manufacture thereof
• H01M 6/30 - Deferred-action cells

Abstract

The present invention relates to a bivalent polypeptide scaffold that facilitates sequential (e.g. stepwise) assembly of molecules to form a single structure. Nucleic acid molecules encoding the polypeptide scaffold, vectors comprising said nucleic acid molecules, and host cells comprising said vectors and nucleic acid molecules are also provided. Kits comprising said polypeptide scaffold and/or nucleic acid molecules/vectors are also provided. Further products comprising said polypeptide scaffold and uses of the polypeptide scaffold of the invention are also provided, e.g. methods of assembling bispecific binding structures.

IPC Classes  ?

• C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/46 - Hybrid immunoglobulins
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

Described is a nanopore that is selectively convertible between an open form and a closed form using light, a method for producing such a nanopore, a method of modulating the flow of one or more substances through the nanopore, the use of the nanopore in modulating ionic flow across an amphiphilic membrane, a device comprising the nanopore, use of the nanopore as an ionotronic component, use of the nanopore in bio-computation and/or bioionotronics, a method of transmitting information using the nanopore, and method of receiving information comprising the nanopore, and an ionotronic component comprising the nanopore.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6869 - Methods for sequencing
• G06N 3/00 - Computing arrangements based on biological models

Abstract

The present invention relates to a therapeutic oligonucleotide having a 5′ and a 3′ end and comprising a sequence of nucleosides linked together by inter-nucleoside linkages, wherein: at least one inter-nucleoside linkage is an amide linker moiety; at least one inter-nucleoside linkage is a phosphorothioate linker moiety; and at least one nucleoside present in the oligonucleotide is a locked nucleoside; wherein the at least one locked nucleoside is directly attached to the 3′ end or the 5′ end of the amide linker moeity. The oligonucleotide has preferably structure (IIa) or (llb): The present invention relates to a therapeutic oligonucleotide having a 5′ and a 3′ end and comprising a sequence of nucleosides linked together by inter-nucleoside linkages, wherein: at least one inter-nucleoside linkage is an amide linker moiety; at least one inter-nucleoside linkage is a phosphorothioate linker moiety; and at least one nucleoside present in the oligonucleotide is a locked nucleoside; wherein the at least one locked nucleoside is directly attached to the 3′ end or the 5′ end of the amide linker moeity. The oligonucleotide has preferably structure (IIa) or (llb):

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Methods and systems are disclosed for detecting characteristics of particles or particle environments. In one arrangement, trajectory data is received that represents detected diffusion trajectories of particles in one or more respective particle environments. Each detected diffusion trajectory comprises a sequence of trajectory segments. Characteristics of particles and/or of the one or more particle environments of the particles are identified by analysing the trajectory segments.

IPC Classes  ?

• G01N 15/1433 - Signal processing using image recognition
• G06T 7/20 - Analysis of motion

Abstract

Systems and methods for optical multiplication are disclosed. In one arrangement, a first modulator comprising rows and columns of first modulator elements is configured to spatially modulate light received from a deflector. The first modulator encodes values of a first matrix. The first matrix defines a plurality of input vectors each corresponding to a respective row of the first matrix. A second modulator spatially modulates light received from the first modulator and encodes values of a second matrix in rows and columns of second modulator elements. A light-summing optical arrangement converges light output from each row of second modulator elements to encode a plurality of output vectors representing the results of vector-matrix multiplication between a respective plurality of the input vectors and the second matrix.

IPC Classes  ?

• G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data

Abstract

Examples relate to an apparatus, for example, a Tensor Processor Unit, for processing, for example, multiplying, first and second Matrix Product States, the apparatus comprising circuitry to: a. receive, or store in memory, first matrix product state data (MPS 1) associated with a first matrix product state; the first matrix product state data comprising first tensor component data associated with the tensor components of the first matrix product state; b. receive, or store in memory, second matrix product state data (MPS 1) associated with a second matrix product state; the second matrix product state data comprising second tensor component data associated with the tensor components of the second matrix product state; c. processing corresponding tensor component data of the first and second matrix product state data to produce tensor contraction data representing a contraction of the tensor components associated with the corresponding tensor component data of the first and second matrix product state data; d. processing copy tensor data representing a copy tensor and the tensor contraction data to produce respective tensor component data; the respective tensor component data representing a contraction of the copy tensor and the contraction of the tensor components associated with the corresponding tensor component data of the first and second matrix product states; and e. associating, or storing in memory, the respective tensor component data with a corresponding tensor component data position of result data representing a resultant matrix product state associated with the processing/multiplying the first and second Matrix Product States.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 17/16 - Matrix or vector computation

Abstract

The invention relates to a process for moving a droplet from a first location to a second location, which droplet comprises a magnetic material disposed in an aqueous medium. The invention also relates to a droplet assembly comprising a droplet, which droplet comprises a magnetic material disposed in an aqueous medium. Various uses of the droplet assembly are also described.

IPC Classes  ?

• H01F 1/44 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A filter system for filtering an input signal comprises a network of Prism filters including at least one cosine Prism filter and at least one sine Prism filter. The network comprises a first branch (210) in parallel with a second branch, (220) each branch arranged to receive the input signal as an input, the first branch comprising the cosine Prism filter/s (211), the second branch comprising the sine Prism filter/s (221). The network of Prism filters is arranged to generate an output signal based on a combination of an output of the first branch with an output of the second branch. A method of designing a convolutional filter is also provided, comprising inputting a test signal into a filter system to generate an impulse response of the filter system and generating a convolutional filter based on the impulse response.

IPC Classes  ?

• H03H 17/02 - Frequency-selective networks
• H03H 17/00 - Networks using digital techniques

Abstract

A parametric system (1) comprising two or more parametric devices (3,4,21,22), arranged in parallel to each other, the parametric system (1) comprising a first input arranged to receive an input signal, means (2, 20, 43, 83) to split the input signal into two or more signal branches, wherein each signal branch is provided to one of the parametric devices (3,4,21,22), means to supply at least one pump signal to each of the parametric devices alongside the input signal, such that each signal branch undergoes an n-wave mixing process at the corresponding parametric device (3,4,21,22), means (16, 20', 20", 27, 48, 70, 84) to combine the output of the parametric devices (3,4,21,22) into an output signal, wherein the output of each parametric device (3,4,21,22) includes signal components including: an amplified signal portion, one or more pump signal and an idler signal; and means to control the relative phase of the pump signals and/or signal branches at each parametric device (3,4,21,22) such that the output signal includes at least a first output signal component formed by the constructive interference of a signal component from each parametric device (3,4,21,22) and a second output signal component formed by the destructive interference of a signal component from each parametric device (3,4,21,22).

IPC Classes  ?

• H03D 7/00 - Transference of modulation from one carrier to another, e.g. frequency-changing
• G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
• H03D 7/14 - Balanced arrangements

Abstract

Systems and methods for generating stimulation signals for brain or nerve stimulation are disclosed. In one arrangement, a signal generation unit generates a stimulation signal and transmits the stimulation signal to a stimulation unit. The stimulation unit applies the stimulation to a biological system. The stimulation signal is defined by at least one stimulation parameter. A data receiving unit receives time series biomarker data comprising measurement samples representing one or more biomarkers indicative of a condition of the biological system that is affected by applied stimulation based on the stimulation signal. A controller controls generation of the stimulation signal based on the received biomarker data. The controller uses a model of the biological system to estimate an optimal value of the at least one stimulation parameter using the biomarker data. The model defines strengths of contribution of measurement samples to the estimate based on the times at which the measurement samples were obtained.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The invention relates to a method (30) comprising: acquiring (32), using an EEG monitoring system (12), EEG data from a subject (16), said data being recorded over a first time period, said first time period including an event; acquiring (34), using a heart rate monitoring system (14), heart rate data from the subject (16), said heart rate data being recorded over a second time period, said second time period also including the event; scaling (36) an EEG template to fit event EEG data at a specified latency following the event to derive an EEG scaling factor; determining (38) a heart rate change due to the event using the heart rate data; and combining (40) the EEG scaling factor and the heart rate change to generate a score indicative of a response of the subject to the event.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/372 - Analysis of electroencephalograms
• A61B 5/383 - Somatosensory stimuli, e.g. electric stimulation
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

Novel compounds comprising x-conjugated moicties are disclosed, as well as their uses as semiconducting materials. The novel compounds comprise adjacent x-electron rich and x-electron deficient moieties. The novel compounds exhibit improved charge mobility and are particularly suited to use in electronic devices and components, such as organic thin film transistors.

IPC Classes  ?

• H10K 85/10 - Organic polymers or oligomers
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

A method of estimating characteristics of an input signal comprises inputting the input signal into a first tracker to determine a first estimate of characteristics of the input signal, and determining a normalised signal from the input signal. The normalised signal is input into a second tracker to determine a second estimate of characteristics of the input signal. At least one of the first tracker and the second tracker comprises or is derived from at least one Prism filter. Further, a method of filtering an input signal is provided. The method comprises applying a sequence of one or more filter stages to the input signal to generate respective downsampled signals. A tracker stage is applied to the output of the final filter stage to determine one or more characteristics of the input signal.

IPC Classes  ?

• G01F 1/84 - Coriolis or gyroscopic mass flowmeters

Abstract

The invention provides an antigen binding polypeptide which is capable of binding to a HLA- E:peptide complex, wherein the antigen binding polypeptide is a HPV-specific TCR or CAR.

IPC Classes  ?

• C07K 14/725 - T-cell receptors

Abstract

Methods and systems for determining neurological health information about a subject are disclosed. In one arrangement, a plurality of training data units are received from training subjects, each training data unit comprising movement data and health category data. The movement data is derived from measurement of training movements. The health category data defines a health category of the training subject. A neural network is trained using the training data units. Training movements are represented by time series data defining a waveform. The trained neural network generates an encoded representation of the waveform of each training movement. A classifying machine learning model is trained to classify the waveforms into corresponding health categories using the generated encoded representations and health category data as training data. Movement data is received from a further subject and the trained neural network and the trained classifying machine learning model are used to determine the health category data of the further subject using the received movement data.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A process for preparing a fluorinating reagent from a calcium-containing compound is disclosed. The process bypasses the requirement to form hydrofluoric acid. The fluorinating reagent can be used to prepare high-value fluorochemicals.

IPC Classes  ?

• C07C 17/20 - Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
• C01B 9/08 - Fluorides

Abstract

The invention relates to antibodies useful for the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses