Abstract

The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.

IPC Classes  ?

• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/12 - Viral antigens
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• C08F 220/54 - Amides
• C08F 220/56 - AcrylamideMethacrylamide
• C08F 220/60 - Amides containing nitrogen in addition to the carbonamido nitrogen

Abstract

A component mounting assembly for mounting a component in a mount structure, the mounting assembly comprising a support body arranged to be connected to the component or to the mount structure; an even number N of beams, N being at least four, wherein said beams are arranged in a loop either outside the support body in the case that the support body is arranged to be connected to the component; or inside the support body in the case that the support body is arranged to be connected to the mount structure; wherein adjacent beams in the loop are connected by respective hinge joints that permit relative rotation of the adjacent beams connected thereby, the beams being integrally formed with each other and the hinge joints being integral connections having a compliance that permits said relative rotation of the adjacent beams connected thereby; wherein each beam is connected to the support body by a respective pivot joint that permit relative rotation of the respective beam and the support body, the beams and the support body being integrally formed, and the pivot joints being integral connections having a compliance that permits said relative rotation of the respective beam and support body; wherein a plurality of said beams comprise contact surfaces arranged to contact either an internal surface of the mount structure in the case that the support body is arranged to be connected to the component; or an external surface of the component the in the case that the support body is arranged to be connected to the mount structure, such that the contact surfaces provide a reaction force to the beams on which they are provided that induces relative rotation of adjacent beams in alternate rotational directions at successive pivot joints around the loop, to thereby align the component relative to the mount structure.

IPC Classes  ?

• G02B 7/00 - Mountings, adjusting means, or light-tight connections, for optical elements

Abstract

An ion trap assembly comprising an ion trap body, a component, and a compliant structure, wherein the compliant structure is a passive alignment structure configured to positionally retain the component relative to the body. In one embodiment, a cantilever beam positionally retains an optical fibre component relative to a groove. This avoids the drawbacks of gluing optical components.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

Examples disclosed herein provide computer-implemented methods and apparatus of generating a realistic front view, FV, of an environment. A method comprises: receiving, as input, a latent floorplan indicative of an environment, the latent floor plan representational of a semantic birds-eye-view, BEV, of the environment; obtaining a volumetric representation of the environment based on the latent floorplan using a neural radiance field, NeRF; obtaining a semantic FV of the environment by volume rendering based on the volumetric representation of the environment; obtaining a realistic FV of the environment based on the semantic FV using a diffusion technique; and outputting the realistic FV of the environment.

IPC Classes  ?

• G06T 15/20 - Perspective computation
• G06T 17/00 - 3D modelling for computer graphics
• G06T 15/08 - Volume rendering

Abstract

The present invention relates to a process for the catalytic decomposition of a polyolefin. More particularly, the present invention relates hydrocarbon-aided catalytic decomposition of a polyolefin using an aluminosilicate.

IPC Classes  ?

• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material

Abstract

An interferometric scattering microscope is adapted by performing spatial filtering of output light, which comprises both light scattered from a sample location and illuminating light reflected from the sample location, prior to detection of the output light. The spatial filtering passes the reflected illumination light but with a reduction in intensity that is greater within a predetermined numerical aperture than at larger numerical apertures. This enhances the imaging contrast for coherent illumination, particularly for objects that are weak scatterers.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01G 9/00 - Methods of, or apparatus for, the determination of weight, not provided for in groups
• G01N 15/1434 - Optical arrangements
• G02B 21/08 - Condensers
• G02B 21/14 - Condensers affording illumination for phase-contrast observation
• G02B 21/26 - StagesAdjusting means therefor
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

P360293WO 44 Abstract Provided is a compound of formula (I) or a pharmaceutically acceptable salt, solvate and/or hydrate thereof which can be used as a radiopharmaceutical agent for the imaging and/or treatment of diseases. Also provided are conjugates of the compound of formula (I) with radionuclides and uses of the conjugates and compositions comprising the conjugates for 5 the imaging and/or treatment of diseases. (I) [Figure 1]

IPC Classes  ?

• C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
• C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• A61P 35/00 - Antineoplastic agents
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Abstract

The present invention relates to novel compounds and methods. The invention particularly provides a compound that finds use in the treatment of cancer by selectively degrading under hypoxic conditions a therapeutic target protein of interest. The compound is a hypoxia-activated proteolysis targeting chimera (hypoxia-activated PROTAC; HAP-TAC).

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• C07D 495/14 - Ortho-condensed systems
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to antibodies for treatment or prevention of malaria.

IPC Classes  ?

• C07K 16/20 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
• A61P 33/06 - Antimalarials

Abstract

The invention relates to a power unit comprising a series of droplets, a method of producing such a power unit, a method of activating such a power unit, an active power unit obtainable from the power unit, a device comprising the power unit or active power unit, a method of generating electric current using the power unit or active power unit, and method of modulating the activities of one or more cells or tissues using the power unit or active power unit.

IPC Classes  ?

• H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen
• H01M 6/26 - Cells without oxidising active material, e.g. Volta cells
• H01M 10/02 - Details
• H01M 10/04 - Construction or manufacture in general
• H01M 10/36 - Accumulators not provided for in groups
• H01M 10/38 - Construction or manufacture
• H01M 14/00 - Electrochemical current or voltage generators not provided for in groups Manufacture thereof
• H01M 6/30 - Deferred-action cells

Abstract

The present invention relates to a bivalent polypeptide scaffold that facilitates sequential (e.g. stepwise) assembly of molecules to form a single structure. Nucleic acid molecules encoding the polypeptide scaffold, vectors comprising said nucleic acid molecules, and host cells comprising said vectors and nucleic acid molecules are also provided. Kits comprising said polypeptide scaffold and/or nucleic acid molecules/vectors are also provided. Further products comprising said polypeptide scaffold and uses of the polypeptide scaffold of the invention are also provided, e.g. methods of assembling bispecific binding structures.

IPC Classes  ?

• C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/46 - Hybrid immunoglobulins
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

Described is a nanopore that is selectively convertible between an open form and a closed form using light, a method for producing such a nanopore, a method of modulating the flow of one or more substances through the nanopore, the use of the nanopore in modulating ionic flow across an amphiphilic membrane, a device comprising the nanopore, use of the nanopore as an ionotronic component, use of the nanopore in bio-computation and/or bioionotronics, a method of transmitting information using the nanopore, and method of receiving information comprising the nanopore, and an ionotronic component comprising the nanopore.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6869 - Methods for sequencing
• G06N 3/00 - Computing arrangements based on biological models

Abstract

The present invention relates to a therapeutic oligonucleotide having a 5′ and a 3′ end and comprising a sequence of nucleosides linked together by inter-nucleoside linkages, wherein: at least one inter-nucleoside linkage is an amide linker moiety; at least one inter-nucleoside linkage is a phosphorothioate linker moiety; and at least one nucleoside present in the oligonucleotide is a locked nucleoside; wherein the at least one locked nucleoside is directly attached to the 3′ end or the 5′ end of the amide linker moeity. The oligonucleotide has preferably structure (IIa) or (llb): The present invention relates to a therapeutic oligonucleotide having a 5′ and a 3′ end and comprising a sequence of nucleosides linked together by inter-nucleoside linkages, wherein: at least one inter-nucleoside linkage is an amide linker moiety; at least one inter-nucleoside linkage is a phosphorothioate linker moiety; and at least one nucleoside present in the oligonucleotide is a locked nucleoside; wherein the at least one locked nucleoside is directly attached to the 3′ end or the 5′ end of the amide linker moeity. The oligonucleotide has preferably structure (IIa) or (llb):

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Methods and systems are disclosed for detecting characteristics of particles or particle environments. In one arrangement, trajectory data is received that represents detected diffusion trajectories of particles in one or more respective particle environments. Each detected diffusion trajectory comprises a sequence of trajectory segments. Characteristics of particles and/or of the one or more particle environments of the particles are identified by analysing the trajectory segments.

IPC Classes  ?

• G01N 15/1433 - Signal processing using image recognition
• G06T 7/20 - Analysis of motion

Abstract

Systems and methods for optical multiplication are disclosed. In one arrangement, a first modulator comprising rows and columns of first modulator elements is configured to spatially modulate light received from a deflector. The first modulator encodes values of a first matrix. The first matrix defines a plurality of input vectors each corresponding to a respective row of the first matrix. A second modulator spatially modulates light received from the first modulator and encodes values of a second matrix in rows and columns of second modulator elements. A light-summing optical arrangement converges light output from each row of second modulator elements to encode a plurality of output vectors representing the results of vector-matrix multiplication between a respective plurality of the input vectors and the second matrix.

IPC Classes  ?

• G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data

Abstract

Examples relate to an apparatus, for example, a Tensor Processor Unit, for processing, for example, multiplying, first and second Matrix Product States, the apparatus comprising circuitry to: a. receive, or store in memory, first matrix product state data (MPS 1) associated with a first matrix product state; the first matrix product state data comprising first tensor component data associated with the tensor components of the first matrix product state; b. receive, or store in memory, second matrix product state data (MPS 1) associated with a second matrix product state; the second matrix product state data comprising second tensor component data associated with the tensor components of the second matrix product state; c. processing corresponding tensor component data of the first and second matrix product state data to produce tensor contraction data representing a contraction of the tensor components associated with the corresponding tensor component data of the first and second matrix product state data; d. processing copy tensor data representing a copy tensor and the tensor contraction data to produce respective tensor component data; the respective tensor component data representing a contraction of the copy tensor and the contraction of the tensor components associated with the corresponding tensor component data of the first and second matrix product states; and e. associating, or storing in memory, the respective tensor component data with a corresponding tensor component data position of result data representing a resultant matrix product state associated with the processing/multiplying the first and second Matrix Product States.

IPC Classes  ?

• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 17/16 - Matrix or vector computation

Abstract

The invention relates to a process for moving a droplet from a first location to a second location, which droplet comprises a magnetic material disposed in an aqueous medium. The invention also relates to a droplet assembly comprising a droplet, which droplet comprises a magnetic material disposed in an aqueous medium. Various uses of the droplet assembly are also described.

IPC Classes  ?

• H01F 1/44 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A filter system for filtering an input signal comprises a network of Prism filters including at least one cosine Prism filter and at least one sine Prism filter. The network comprises a first branch (210) in parallel with a second branch, (220) each branch arranged to receive the input signal as an input, the first branch comprising the cosine Prism filter/s (211), the second branch comprising the sine Prism filter/s (221). The network of Prism filters is arranged to generate an output signal based on a combination of an output of the first branch with an output of the second branch. A method of designing a convolutional filter is also provided, comprising inputting a test signal into a filter system to generate an impulse response of the filter system and generating a convolutional filter based on the impulse response.

IPC Classes  ?

• H03H 17/02 - Frequency-selective networks
• H03H 17/00 - Networks using digital techniques

Abstract

A parametric system (1) comprising two or more parametric devices (3,4,21,22), arranged in parallel to each other, the parametric system (1) comprising a first input arranged to receive an input signal, means (2, 20, 43, 83) to split the input signal into two or more signal branches, wherein each signal branch is provided to one of the parametric devices (3,4,21,22), means to supply at least one pump signal to each of the parametric devices alongside the input signal, such that each signal branch undergoes an n-wave mixing process at the corresponding parametric device (3,4,21,22), means (16, 20', 20", 27, 48, 70, 84) to combine the output of the parametric devices (3,4,21,22) into an output signal, wherein the output of each parametric device (3,4,21,22) includes signal components including: an amplified signal portion, one or more pump signal and an idler signal; and means to control the relative phase of the pump signals and/or signal branches at each parametric device (3,4,21,22) such that the output signal includes at least a first output signal component formed by the constructive interference of a signal component from each parametric device (3,4,21,22) and a second output signal component formed by the destructive interference of a signal component from each parametric device (3,4,21,22).

IPC Classes  ?

• H03D 7/00 - Transference of modulation from one carrier to another, e.g. frequency-changing
• G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
• H03D 7/14 - Balanced arrangements

Abstract

Systems and methods for generating stimulation signals for brain or nerve stimulation are disclosed. In one arrangement, a signal generation unit generates a stimulation signal and transmits the stimulation signal to a stimulation unit. The stimulation unit applies the stimulation to a biological system. The stimulation signal is defined by at least one stimulation parameter. A data receiving unit receives time series biomarker data comprising measurement samples representing one or more biomarkers indicative of a condition of the biological system that is affected by applied stimulation based on the stimulation signal. A controller controls generation of the stimulation signal based on the received biomarker data. The controller uses a model of the biological system to estimate an optimal value of the at least one stimulation parameter using the biomarker data. The model defines strengths of contribution of measurement samples to the estimate based on the times at which the measurement samples were obtained.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The invention relates to a method (30) comprising: acquiring (32), using an EEG monitoring system (12), EEG data from a subject (16), said data being recorded over a first time period, said first time period including an event; acquiring (34), using a heart rate monitoring system (14), heart rate data from the subject (16), said heart rate data being recorded over a second time period, said second time period also including the event; scaling (36) an EEG template to fit event EEG data at a specified latency following the event to derive an EEG scaling factor; determining (38) a heart rate change due to the event using the heart rate data; and combining (40) the EEG scaling factor and the heart rate change to generate a score indicative of a response of the subject to the event.

IPC Classes  ?

• A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/372 - Analysis of electroencephalograms
• A61B 5/383 - Somatosensory stimuli, e.g. electric stimulation
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

Novel compounds comprising x-conjugated moicties are disclosed, as well as their uses as semiconducting materials. The novel compounds comprise adjacent x-electron rich and x-electron deficient moieties. The novel compounds exhibit improved charge mobility and are particularly suited to use in electronic devices and components, such as organic thin film transistors.

IPC Classes  ?

• H10K 85/10 - Organic polymers or oligomers
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

A method of estimating characteristics of an input signal comprises inputting the input signal into a first tracker to determine a first estimate of characteristics of the input signal, and determining a normalised signal from the input signal. The normalised signal is input into a second tracker to determine a second estimate of characteristics of the input signal. At least one of the first tracker and the second tracker comprises or is derived from at least one Prism filter. Further, a method of filtering an input signal is provided. The method comprises applying a sequence of one or more filter stages to the input signal to generate respective downsampled signals. A tracker stage is applied to the output of the final filter stage to determine one or more characteristics of the input signal.

IPC Classes  ?

• G01F 1/84 - Coriolis or gyroscopic mass flowmeters

Abstract

The invention provides an antigen binding polypeptide which is capable of binding to a HLA- E:peptide complex, wherein the antigen binding polypeptide is a HPV-specific TCR or CAR.

IPC Classes  ?

• C07K 14/725 - T-cell receptors

Abstract

Methods and systems for determining neurological health information about a subject are disclosed. In one arrangement, a plurality of training data units are received from training subjects, each training data unit comprising movement data and health category data. The movement data is derived from measurement of training movements. The health category data defines a health category of the training subject. A neural network is trained using the training data units. Training movements are represented by time series data defining a waveform. The trained neural network generates an encoded representation of the waveform of each training movement. A classifying machine learning model is trained to classify the waveforms into corresponding health categories using the generated encoded representations and health category data as training data. Movement data is received from a further subject and the trained neural network and the trained classifying machine learning model are used to determine the health category data of the further subject using the received movement data.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to antibodies useful for the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses

Abstract

There is provided an optical fibre comprising a first portion and a second portion, wherein: the second portion is a void portion comprising one or more voids, wherein the one or more voids extend longitudinally along the length of the optical fibre within the void portion; the first portion and the second portion are substantially mode-matched; and the one or more voids are at least partially filled with a filler having a material property different to the material property of a material of the optical fibre.

IPC Classes  ?

• G02B 6/02 - Optical fibres with cladding
• G01K 11/3206 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres at discrete locations in the fibre, e.g. using Bragg scattering
• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

Abstract

The present invention relates to polynucleotides comprising a plant cell promoter element operatively linked to a nucleotide sequence that encodes a water-forming oxidase. The invention also relates to methods for increasing the growth and yield of plants.

IPC Classes  ?

• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

A liquid crystal device (400) is provided comprising: a liquid crystal layer having a thickness and comprising: a liquid crystal material; and a plurality of polymer structures (414a, 414b) comprising polymerised liquid crystal material. Each polymer structure (414a, 414b) is located at a different depth in the thickness of the liquid crystal layer. Electrodes are provided configured to apply an electric field to the liquid crystal layer. Each polymer structure (414a, 414b) has a different selected locked-in liquid crystal state.

IPC Classes  ?

• G02F 1/1334 - Constructional arrangements based on polymer-dispersed liquid crystals, e.g. microencapsulated liquid crystals
• G02F 1/1343 - Electrodes

Abstract

Processes for the preparation of fluorochemicals are described, in which a fluoride source is pulverised together with an activator and optionally a sequestrant. Fluorochemicals resulting from the processes are also described.

IPC Classes  ?

• C01D 3/02 - Fluorides
• C01D 15/04 - Halides
• C01F 5/02 - Magnesia
• C01F 11/00 - Compounds of calcium, strontium, or barium
• C01F 11/10 - Oxides or hydroxides from sulfides
• C01G 21/06 - Lead monoxide [PbO]
• C01G 21/22 - PlumbatesPlumbites
• C01G 23/00 - Compounds of titanium
• C01G 39/00 - Compounds of molybdenum
• C01G 41/00 - Compounds of tungsten

Abstract

The present invention relates to processes for preparing fluorochemicals. The present invention also relates to the fluorochemicals resulting from the processes of the present invention. The processes of the present invention can avoid the need to use hydrofluoric acid as an intermediate for fluorochemical production.

IPC Classes  ?

• C07B 39/00 - Halogenation
• C07C 25/13 - Monocyclic aromatic halogenated hydrocarbons containing fluorine
• C07C 247/16 - Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
• C07F 5/02 - Boron compounds
• C07F 7/12 - Organo silicon halides
• C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Abstract

A method for characterising a perivascular region using medical imaging data of a subject. The method comprises calculating the value of a radiomic signature of the perivascular region using the medical imaging data. Also disclosed is a method for deriving a radiomic signature for predicting cardiovascular risk. The method comprises obtaining a radiomic dataset and using the radiomic dataset to construct a perivascular radiomic signature. Also disclosed are systems for performing the aforementioned methods.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• G06N 20/00 - Machine learning
• G06T 7/40 - Analysis of texture
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The invention relates to a process for producing a compound comprising an 18F-difluoromethyl group or a compound comprising an 18F-difluoromethylene group, which process comprises contacting a compound comprising a nucleophilic group with 18F-difluorocarbene. The invention also relates to a compound of Formula (I). Compounds comprising an 18F-difluoromethyl group or an 18F-difluoromethylene group are also the subject of the present invention.

IPC Classes  ?

• C07C 17/361 - Preparation of halogenated hydrocarbons by reactions involving a decrease in the number of carbon atoms
• A61K 31/025 - Halogenated hydrocarbons carbocyclic
• A61K 31/085 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61K 31/11 - Aldehydes
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine

Abstract

A method for characterising a region of interest comprising adipose tissue using medical imaging data. e.g. based on computer tomography (CT) of a subject is disclosed. The method comprises calculating the value of a radiomic signature of the region of interest using the medical imaging data. Also disclosed is a method for deriving a radiomic signature indicative of adipose tissue dysfunction. The method comprises obtaining a radiomic dataset and using the radiomic dataset to construct a radiomic signature of a region of interest comprising adipose tissue. Also disclosed are systems for performing the aforementioned methods.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06T 7/40 - Analysis of texture
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

The invention relates to an antibody or antigen binding fragment thereof which is capable of binding to CD1a, which is particularly suitable for treating or preventing one or more inflammatory skin or mucosal disorder, or disease or one or more associated systemic disease or disorder, or one or more inflammatory drug reaction which manifests systemically, or a CD1a-expressing malignancy

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

According to examples of the invention, there is provided a method of image generation using magnetic resonance imaging, MRI, with echo-planar imaging, EPI. The method comprises transmitting a RF pulse (411) to a subject in a static magnetic field in the presence of an applied spatial magnetic field gradient; receiving magnetic resonance, MR, signals; sampling the received MR signals to acquire a plurality of temporarily adjacent EPI volumes and generating a k space map (601) for the plurality of EPI volumes by: applying an oscillating readout gradient (417) over each of the plurality of EPI volumes to obtain readout data along a readout axis; and applying a phase encoding gradient (415), while applying the oscillating readout gradient (417), such that trajectory lines of readout data for each of the plurality of EPI volumes are interleaved in k space using a periodic rewinding pattern along a phase encoding axis. The method comprises dividing the generated k space map (601) into a plurality of k space sub-maps (603a, 603b, 603c), each of the plurality of k space sub-maps (603a, 603b, 603c) associated with one of the plurality of EPI volumes and applying an optimisation function utilising shared information across the plurality of k space sub-maps (603a, 603b, 603c) to jointly reconstruct k space data; and generating an image (621) based on the jointly reconstructed k space data.

IPC Classes  ?

• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G01R 33/48 - NMR imaging systems
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/565 - Correction of image distortions, e.g. due to magnetic field inhomogeneities

Abstract

Provided herein are method for detecting the interaction of a protein of interest and an analyte. Also provided herein are polypeptides, nucleic acids, cells and kits suitable for attaching a protein of interest to a cell. Also provided herein are cells and populations of cells comprising a protein of interest and methods for preparing said cells and populations thereof.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• C12N 5/07 - Animal cells or tissues
• C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor

Abstract

A method calculates a score representing cardiovascular condition progression cardiovascular condition using feature data comprising cardiovascular image features from a population including a background group and a target group at a later stage of the condition. Contrastive principal component analysis is applied between feature data from the background and target groups to obtain a transformation into a reduced representation space, which is applied to the population feature data to determine positions of each individual in the space. Trajectories are determined in the space between the target and background groups by connecting the positions. The score is calculated as a distance along the one of the trajectories on which the position of an individual lies. Another method calculates a contribution of each of the plurality of features to the transformation, and determines a plurality of features having the highest contributions. Other methods derive models for calculating the score by fitting.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A process for the polymerisation of propylene is described, in which the resulting polypropylene is high molecular weight atactic polypropylene. Also described is high molecular weight and ultra-high molecular weight atactic polypropylene.

IPC Classes  ?

• C08F 110/06 - Propene

Abstract

The present invention relates to the electrochemical detection of a target protein in a sample typically comprising a protein ensemble, which utilises shotgun tagging of protein in the sample followed by selective binding of tagged, target protein and electrochemical sensing thereof.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/327 - Biochemical electrodes
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a composition comprising OMVs obtained from a modified Neisseria gonorrhoeae strain expressing a PorB variant, methods for preparing said composition, and its uses including vaccines.

IPC Classes  ?

• A61K 39/095 - Neisseria
• A61P 31/04 - Antibacterial agents

Abstract

The invention provides an assay useful in predicting risk of capecitabine-induced toxicity in a subject. The subject may be screened for the presence of at least one polymorphism of the invention. Suitable polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing capecitabine-induced toxicity; a negative result may indicate a decreased risk of developing capecitabine-induced toxicity.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A scattering microscopy arrangement uses a microscope to image an object comprising a surface. A light source emits illuminating light and a light detector detects light elastically scattered from the object. An electric potential is applied to the surface that affects the electrochemical properties of the object while imaging. The electric potential provides a contrast mechanism that improves the imaging and allows for characterisation of the object and/or the surrounding environment.

IPC Classes  ?

• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

The present invention provides a rhodium-catalysed, enantioselective process for preparing a compound of formula (IV), as defined herein, comprising a step of reacting a compound of formula (V), as defined herein, with a compound of formula (V)I, as defined herein, in the presence of a rhodium species, a chiral ligand and optionally a base. Further aspects of the present invention relate to the preparation of a piperidine compounds of formula (I), as defined herein, utilising said enantioselective a rhodium-catalysed reaction. Also provided are intermediates of formula (IV) and sub-formulae thereof.

IPC Classes  ?

• C07D 211/70 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 211/16 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
• C07D 211/20 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
• C07D 211/22 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by oxygen atoms
• C07D 211/24 - Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms by sulfur atoms to which a second hetero atom is attached
• C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07F 7/08 - Compounds having one or more C—Si linkages

Abstract

The invention relates to modulating the expression or activity of a gene by modulating the presence of a regulatory element in the corresponding RNA transcript using a compound targeted to a splicing signal in the RNA transcript to induce splice modulation of one or more exons comprising the regulatory element.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/86 - Viral vectors

Abstract

A method of monitoring a transmission includes obtaining one or more values of bit error rate (BER) of the transmission received at a receiver; and determining that the transmission has been intercepted based on a deviation of the obtained bit error rate value from an expected bit error rate value.

IPC Classes  ?

• H04L 9/40 - Network security protocols
• H04L 9/08 - Key distribution

Abstract

The present invention relates to antibodies capable of binding to the spike protein of coronavirus SARS-CoV-2, and methods and uses thereof in the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to the use of a reduced folate, such as 5-MTHF (5-methyltetrahydrofolate), optionally in combination with tetrahydrobiopterin (BH4) or precursors thereof, for preventing or treating disorders associated with a BH4 deficiency, or low BH4 bioavailability. Such disorders primarily include diseases which have vascular endothelial pathology, or effects on amino acid metabolism or neurotransmission, especially pregnancy related disorders such as pre-eclampsia.

IPC Classes  ?

• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 9/12 - Antihypertensives
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes

Abstract

In one arrangement, an apparatus comprises an elongate sheath insertable through the vascular system to a target site. A filter arrangement extends from a distal end of the sheath and comprises a porous membrane switchable between a radially contracted state and a radially expanded state. The radially expanded state is such as to span a cross- section of a blood vessel to block debris from travelling past the porous membrane. A filter actuation system hydraulically switches the porous membrane between the radially contracted state and the radially expanded state.

IPC Classes  ?

• A61F 2/01 - Filters implantable into blood vessels

Abstract

The present invention relates to novel systems, polypeptides, compounds and methods. The invention provides an inducible degron for target-specific protein degradation.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61P 35/00 - Antineoplastic agents
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

Methods and apparatus for classifying phytoplankton cells are described. In some examples, the methods comprise acquiring transient data indicative of a change in luminescence of the phytoplankton cell after exposure to excitation radiation and classifying the phytoplankton cell using the transient data as an input to a trained classifier, wherein the classifier is trained using classified transient data for a plurality of phytoplankton cells.

IPC Classes  ?

• G06V 10/143 - Sensing or illuminating at different wavelengths
• G06V 10/60 - Extraction of image or video features relating to illumination properties, e.g. using a reflectance or lighting model
• G06V 10/62 - Extraction of image or video features relating to a temporal dimension, e.g. time-based feature extractionPattern tracking
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

Methods and apparatus for providing embolic protection during a transcatheter operation are disclosed. In one arrangement, an apparatus comprises an elongate sheath insertable through the vascular system to a target site. A filter arrangement extends from a distal end of the sheath. The sheath is switchable between a radially contracted state and a radially expanded state. The sheath in the radially expanded state defines a central lumen for allowing insertion of a device for performing a transcatheter operation. The filter arrangement comprises a porous membrane switchable between a radially contracted state and a radially expanded state. The radially expanded state is such as to span a cross-section of a blood vessel to block debris from travelling past the porous membrane. A filter actuation system switches the porous membrane between the radially contracted state and the radially expanded state.

IPC Classes  ?

• A61F 2/01 - Filters implantable into blood vessels

Abstract

An interferometric displacement measurement apparatus (100) includes at least one measurement interferometer (103) for measuring a change in optical path difference between a measurement beam (150) and a reference beam. A light source module (118) is arranged to generate a modulated light beam, having a particular optical spectrum, from which the measurement beam and reference beam are derived. A data acquisition and analysis module (105) can determine a measure representative of the displacement using interference intensity data received from a photodetector (111) which detects the interference of the measurement beam with the reference beam.

IPC Classes  ?

• G01B 9/02003 - Interferometers characterised by controlling or generating intrinsic radiation properties using two or more frequencies using beat frequencies
• G01B 9/02001 - Interferometers characterised by controlling or generating intrinsic radiation properties
• G01B 9/02015 - Interferometers characterised by the beam path configuration

Abstract

A device comprising a diamond substrate, wherein: the substrate comprises a device track formed by modifying the structure of carbon within the substrate; and electrical conductivity along the device track is asymmetric. A method of manufacturing a device, the method comprising: forming a device track having asymmetric electrical conductivity along the device track by modifying the structure of carbon within a diamond substrate.

IPC Classes  ?

• H01L 21/268 - Bombardment with wave or particle radiation with high-energy radiation using electromagnetic radiation, e.g. laser radiation
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/861 - Diodes

Abstract

Provided is a process for producing one or more aromatic compounds comprising exposing a feed composition comprising at least one plastic to microwave radiation in the presence of a solid catalyst composition, wherein the solid catalyst composition comprises a solid acid catalyst and a carbon source. Also provided is a solid catalyst composition suitable for use in said process and for upcycling plastic.

IPC Classes  ?

• C08J 11/16 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with inorganic material
• B01J 29/40 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereof of the pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11

Abstract

A multiplexer is disclosed for multiplexing signals from a plurality of readout resonators of a circuit QED device. In one arrangement, the multiplexer comprises a cavity resonator system comprising one or more inner conductors and an outer conductor. The outer conductor comprises a plurality of openings and surrounds the one or more inner conductors in directions other than towards the openings. A signal port system is coupled to the cavity resonator system and configured to receive multiplexed signals from the readout resonators. The readout resonators are provided in a common plane. One of the inner conductors is configured to capacitively couple to the readout resonators through respective openings in a direction extending perpendicularly or obliquely relative to the plane.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

A carbon sequestration unit (1) comprises a support layer (10) configured to support a photosynthetic organism (12), a growth substrate (14) for the photosynthetic organism disposed along the support layer, and an irrigation pipe (16) configured to release water along its length for irrigating the photosynthetic organism. The support layer has a shape that is convoluted in three dimensions allowing for growth surface maximisation compared to the land on which the carbon sequestration unit is deployed.

IPC Classes  ?

• B01D 53/62 - Carbon oxides
• B01D 53/85 - Biological processes with gas-solid contact

Abstract

Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• C07K 19/00 - Hybrid peptides
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25.

IPC Classes  ?

• C12N 15/861 - Adenoviral vectors
• A61K 35/761 - Adenovirus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/04 - Mycobacterium, e.g. Mycobacterium tuberculosis
• A61K 39/12 - Viral antigens
• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• A61K 39/21 - Retroviridae, e.g. equine infectious anemia virus
• A61K 39/235 - Adenoviridae
• A61P 31/06 - Antibacterial agents for tuberculosis
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• C12N 15/86 - Viral vectors

Abstract

The invention describes ultrasound-responsive particles comprising a polypeptide shell. The surface of the particle has one or more indentations which are generally able to entrap a gas bubble. The particles are capable of generating inertial cavitation on exposure to ultrasound. The particles are therefore useful in methods of treatment which involve inertial cavitation and in the delivery of drugs to target sites via inertial cavitation.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/51 - Nanocapsules
• A61K 49/22 - Echographic preparationsUltrasound imaging preparations

Abstract

The invention describes ultrasound-responsive particles having a core containing one or more therapeutic or diagnostic agents, and a polypeptide shell. The surface of the particle has one or more indentations which are generally able to entrap a gas bubble. The particles are capable of generating inertial cavitation on exposure to ultrasound. The inertial cavitation properties of the particles can be used to enhance delivery of the therapeutic or diagnostic agents to target sites in vivo.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

Abstract

Computer-implemented methods for generating neural networks, and methods for classifying physiological data and patients based on the generated networks, are provided. The methods comprise determining values of a plurality of hyperparameters based on one or more properties of the received input data, which may be physiological data. A neural network comprising a plurality of layers is generated based on the hyperparameters, and is trained using the input data. If a first predetermined condition is not met, the values of one or more of the hyperparameters are updated. The steps of generating and training a neural network are repeated until the first predetermined condition is met. When the first predetermined condition is met, one of the trained neural networks is selected and is output.

IPC Classes  ?

• G06N 3/082 - Learning methods modifying the architecture, e.g. adding, deleting or silencing nodes or connections
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

Abstract

This disclosure teaches multi-classification of endoscopic imaging using a segmentation neural network. The network is trained on imaging data using a novel loss function with components of both focal and boundary loss. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data and inference data from its prior learning, the segmentation neural network identifies renal calculi and surgical instruments within the imaging data. The imaging data is modified and displayed to assist the lithotripsy procedure.

IPC Classes  ?

• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• A61B 5/20 - Measuring urological functions
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

A photonic content addressable memory (CAM) (100) is provided. The photonic CAM (100) comprises: N search lines (101) and a plurality of match lines (102), each match line comprising N photonic CAM cells (110). Each search line (101) is configured to receive a search optical signal and each search optical signal comprises a different wavelength encoding one of N parallel search symbols. Each match line (102) is configured to receive: a wavelength division multiplexed content optical signal comprising a plurality of wavelengths, each wavelength encoding one of N parallel content symbols; and the N search optical signals from the N search lines (101). Each photonic CAM cell is configured to compare a respective search symbol with a respective content symbol and provide an output optical signal that is responsive to the comparison. Each match line (102) also comprises a content optical demultiplexer (120), configured to demultiplex the wavelength division multiplexed content optical signal and provide each CAM cell (110) with the respective content symbol.

IPC Classes  ?

• G11C 13/04 - Digital stores characterised by the use of storage elements not covered by groups , , or using optical elements
• G11C 15/00 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores

Abstract

This disclosure teaches multi-classification of endoscopic imaging using a segmentation neural network. The network is trained on imaging data using a novel loss function with components of both focal and boundary loss. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data and inference data from its prior learning, the segmentation neural network identifies renal calculi and surgical instruments within the imaging data. The imaging data is modified and displayed to assist the lithotripsy procedure.

IPC Classes  ?

• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
• A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
• G06V 10/14 - Optical characteristics of the device performing the acquisition or on the illumination arrangements
• G06V 10/22 - Image preprocessing by selection of a specific region containing or referencing a patternLocating or processing of specific regions to guide the detection or recognition
• G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
• G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06V 10/776 - ValidationPerformance evaluation
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks

Abstract

This disclosure teaches determining a renal calculus size based on calibration data generated from an endoscopic imager. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data, the generated calibration data, and known properties of the endoscopic probe, one or more renal calculi in the images are identified and sized. The determined size values are displayed with the images of the renal calculi.

IPC Classes  ?

• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

The present invention relates to diagnostic screens, antibodies, methods and kits for detection/prognosis of acute myeloid leukaemia. The diagnostic screen detects the presence (+) or absence (−) of the cell surface polypeptide markers i) CD34+; ii) CD45RA+; and iii) CD90− and/or CD123+. Antibodies specific for one or more of said cell surface polypeptide markers may be used in the diagnostic screen of the invention. Diagnostic and prognostic methods for detecting and monitoring minimal residual disease based on said screen also form part of the invention.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

This disclosure teaches determining a renal calculus size based on calibration data generated from an endoscopic imager. During a lithotripsy procedure, images are received by a deployed endoscopic probe. Based on the received imaging data, the generated calibration data, and known properties of the endoscopic probe, one or more renal calculi in the images are identified and sized. The determined size values are displayed with the images of the renal calculi.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes

Abstract

22 (or CO) to methanol.

IPC Classes  ?

• B01J 21/08 - Silica
• B01J 23/80 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with zinc, cadmium or mercury
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 37/03 - PrecipitationCo-precipitation
• C07C 29/153 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used

Abstract

A multi-mode waveguide is provided, the waveguide configured to support at least two degenerate modes of electromagnetic fields. The waveguide comprises an input node configured to couple electromagnetic fields into the waveguide. An output node is configured to couple electromagnetic fields out of the waveguide. A perturbation is configured to couple the two degenerate modes within the waveguide. The input node and the output node are positioned such that coupled degenerate modes clockwise and counter-clockwise propagating waves within the waveguide with at least two transmission minima. A waveguide device comprising a plurality of such multi-mode waveguides is also provided, the waveguide device having a plurality of transmission minima.

IPC Classes  ?

• H01P 1/208 - Cascaded cavitiesCascaded resonators inside a hollow waveguide structure
• H01P 3/123 - Hollow waveguides with a complex or stepped cross-section, e.g. ridged or grooved waveguides

Abstract

Provided herein are methods of characterising a peptide, polypeptide or protein and of characterising one or more proteoforms of a peptide, polypeptide or protein, using nanopores. Also provided herein are associated systems.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

A method of detecting a protein by mass spectrometry comprises: providing a solution comprising a hybrid detergent and a protein; providing a mass spectrometer comprising a nanoelectrospray ionisation source; vaporising the solution; ionising the protein; resolving the ionised protein; and detecting the resolved protein. The mass spectrometry methods may be used to interrogate the lipidome of a protein of interest, and/or for analysing membrane proteins in the form of complexes with ligands, and in particular lipids.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07C 43/13 - Saturated ethers containing hydroxy or O-metal groups
• C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
• C09K 23/42 - Ethers, e.g. polyglycol ethers of alcohols or phenols

Abstract

The present invention relates to a sensing assembly comprising a solid support and a receptor, wherein the sensing assembly is suitable for detecting sulphide. The present invention also relates to methods of detecting sulphide using the sensing assembly of the present invention.

IPC Classes  ?

• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
• C07F 5/02 - Boron compounds
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Abstract

There is provided a method for determining a location of a source of neural activity signals within a brain. The method comprises measuring electrical signals from respective contacts of a plurality of contacts located at known relative positions within the brain, processing the electrical signals to detect neural activity signals in the electrical signals from the respective contacts, determining timings of the detected neural activity signals, and determining the location of the source of neural activity within the brain relative to the plurality of contacts by fitting a source model to the timings relative to each other, wherein the source model models an arrangement of the source of the neural activity signals and models the neural activity signals as travelling waves that propagate through the brain. The location of the source of neural activity can be used to guide optimal delivery of deep brain stimulation.

IPC Classes  ?

• A61B 5/31 - Input circuits therefor specially adapted for particular uses for electroencephalography [EEG]
• A61B 5/37 - Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
• A61B 5/374 - Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

A hypoxia inducible factor prolyl hydroxylase inhibitor (PHD inhibitor) for use in the treatment of blood cancer.

IPC Classes  ?

• C07D 239/54 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/415 - 1,2-Diazoles
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to antigens, antibodies and vaccines for treatment or prevention of malaria.

IPC Classes  ?

• A61K 39/015 - Hemosporidia antigens, e.g. Plasmodium antigens
• A61P 33/06 - Antimalarials
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

A compound which is a substituted azine of formula (I), a substituted pyrimidine of formula (IV), or a pharmaceutically acceptable salt thereof

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/415 - 1,2-Diazoles
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid

Abstract

The present invention relates to certain compounds that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection.

IPC Classes  ?

• C07D 209/42 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 31/04 - Antibacterial agents
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Methods and systems are disclosed for electrically stimulating a nerve to cause muscle contraction. In one arrangement, a plurality of electrodes is positioned in contact with skin. The electrodes allow electrical stimulation to be directed independently towards a plurality of different stimulation regions below the skin via a corresponding plurality of combinations of the electrodes. For each combination of electrodes, a test stimulation is applied using the combination of electrodes and a response to the test stimulation is measured. One or a subset of stimulation regions is selected based on the measured responses. A therapy stimulation is applied to each selected stimulation region using the combination of electrodes corresponding to the selected stimulation region.

IPC Classes  ?

• A61N 1/04 - Electrodes
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/39 - Heart defibrillators

Abstract

The invention relates to an isolated proteinaceous particle comprising a core of perform and/or granzyme, the core being surrounded by a glycoprotein shell comprising thrombospondin-1 (TSP-1) or a fragment thereof, a variant thereof or an orthologue thereof. The invention further relates to nn engineered proteinaceous particle comprising a core of perform and/or granzyme, the core being surrounded by a glycoprotein shell comprising a thrombospondin protein, or a fragment thereof, a variant thereof or an orthologue thereof, wherein the granzyme and/or the thrombospondin is genetically modified. Further related materials, medical uses and manufacture are also contemplated.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/00 - Medicinal preparations containing peptides
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Abstract

The present invention relates to compounds of formula (I) which are inhibitors of 3C like proteases, pharmaceutical compositions comprising such compounds, and the compounds for use in methods of treating viral infections caused by viruses comprising 3C-like proteases.

IPC Classes  ?

• C07D 207/20 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 209/02 - Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61P 31/12 - Antivirals
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

Compounds suitable for use in the polymerisation of olefins, such as ethylene, are described. Also described is a process for polymerising olefins using the described compounds. The compounds exhibit high polymerisation activities and afford polyolefins having industrially desirable properties, including high molecular weight and low polydispersity.

IPC Classes  ?

• C08F 10/02 - Ethene
• C07F 17/00 - Metallocenes

Abstract

Catalyst supports prepared from Ni2+-containing layered double hydroxides are disclosed. together with processes by which they are made and catalyst compositions comprising them. When used in the polymerisation of an olefin. the catalyst supports give control over the molecular weight distribution of the resulting polyolefin.

IPC Classes  ?

• C08F 110/02 - Ethene
• C01F 7/785 - Hydrotalcite

Abstract

A driver (1) for a plasma particle accelerator includes a plasma (10) and laser system(s) (2) that generate first and second pulses. The first pulse (4) has a duration less than the electron plasma period. The second pulse (6) is temporally smooth and has a duration greater than the electron plasma period and less than the ion plasma period. The first pulse generates a plasma wake and the second pulse interacts with the wake to form red and blue-shifted sidebands. The driver also includes a dispersive optical device (20) that introduces a chromatic dispersion to shift the spectral phases of the red and blue-shifted sidebands, to temporally shift them relative to each other, so as to form coincident pulses (22) for generating a plasma wake in a plasma particle accelerator (26).

IPC Classes  ?

• H05H 15/00 - Methods or devices for acceleration of charged particles not otherwise provided for
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media

Abstract

Methods, apparatus and computer readable media are provided for identifying functional features from a computed tomography (CT) image. The CT image may be a contrast-enhanced CT image or a non-contrast CT image. According to some examples, methods, apparatus and computer readable media are also provided for using machine learning to identify functional features from CT images. According to some examples, simulated functional image datasets such as simulated PET images or simulated SUV images are generated from a received CT image.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Health of electrochemical energy supply elements is determined from sensor data representing sensed parameters of the electrochemical energy supply elements. A model of a health parameter that is dependent on operational parameters derivable from the sensor data and on health of the electrochemical energy supply element is fitted over the sensor data. The distribution of the health parameter is modelled as a Gaussian Process having an overall kernel combining a first kernel modelling dependency on the operational parameters and a second, non-stationary kernel modelling degradation over time. Health metrics over time for respective electrochemical energy supply elements are derived, comprising values of the health parameter that are predicted by the fitted model in respect of a predetermined operating point of the operational parameters. The health parameter is informative of the health of the electrochemical energy supply element and may be used as an input variable to a machine learning classifier.

IPC Classes  ?

• G01R 31/392 - Determining battery ageing or deterioration, e.g. state of health
• G01R 31/367 - Software therefor, e.g. for battery testing using modelling or look-up tables
• G01R 31/387 - Determining ampere-hour charge capacity or SoC
• G01R 31/389 - Measuring internal impedance, internal conductance or related variables

Abstract

The present invention provides a process for producing hydrogen comprising exposing a liquid composition comprising a hydrocarbon to electromagnetic radiation in the presence of a solid catalyst, wherein the catalyst comprises: at least one metal species, comprising one or more elements selected from Fe, Ni and Co; and a non-oxygenated ceramic. Also provided are a heterogeneous mixture comprising a solid catalyst in intimate mixture with a liquid composition comprising a hydrocarbon wherein the catalyst comprises: at least one metal species comprising Fe and/or Ni; and a non-oxygenated ceramic. Also provided are the use of said mixture to produce hydrogen, a microwave reactor comprising said mixture and a vehicle comprising said reactor. Furthermore, the invention provides a fuel cell module comprising a (i) a fuel cell and (ii) a heterogeneous mixture as described herein, and a vehicle or electronic device comprising said fuel cell module.

IPC Classes  ?

• C01B 3/26 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons using catalysts

Abstract

The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/03 - Computed tomography [CT]
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• G06T 7/00 - Image analysis
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

The invention relates to a peptide mass tag for recovery and identification of target proteins by mass spectrometry. The invention further relates to fusion polypeptides including the peptide mass tag and a method of analysing a target protein comprising use of the peptide mass tag.

IPC Classes  ?

• G01N 33/563 - ImmunoassayBiospecific binding assayMaterials therefor involving antibody fragments
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Immunogenic compositions and methods of their use in eliciting immune responses to coronaviruses, such as SARS-CoV-2 are provided.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 9/51 - Nanocapsules
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/14 - Hydrolases (3.)
• C12N 15/86 - Viral vectors
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

A method (100) of training an image processing unit (27) for use in optical imaging, the method (100) comprising: providing (102) a training object (37); computing (104) a plurality of theoretically expected signals generated by detecting the component of the electromagnetic field arriving from the object (37) in each of a plurality of different spatial modes of light; and generating (106) a reconstructed image (39) based on the theoretically expected signals, wherein the reconstructed image (39) is provided as a label for the training object (37) for use in training the image processing unit (27).

IPC Classes  ?

• G06T 3/4069 - Scaling of whole images or parts thereof, e.g. expanding or contracting based on super-resolution, i.e. the output image resolution being higher than the sensor resolution by subpixel displacements
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G06T 3/4046 - Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks

Abstract

The invention provides methods for prognosing an increased risk of early onset preeclampsia (EOPE) in a pregnant subject before the disease onset. The methods comprises quantifying small extracellular vesicles that express pairs of biomarkers selected from CD10, CD63 and placental alkaline phosphatase (PLAP) in a sample obtained from the subject.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61P 9/12 - Antihypertensives

Abstract

A method is provided for detection of birefringent particles in a blood sample from a subject. The blood sample is processed to lyse red blood cells and the processed blood sample is imaged using an optical microscope configured for back scattering dark field microscopy. The imaging comprises illuminating the processed blood sample with light having a first polarisation state, capturing an image of light scattered by the processed blood sample having a second polarisation state different from the first polarisation state, and analysing the image to identify birefringent particles. Either a magnification of the optical microscope is at most 10x magnification; or a thickness of the processed blood sample is greater than a depth of field of the optical microscope and the imaging further comprises scanning the focal plane of the optical microscope through the thickness of the processed blood sample during the capturing of the image.

IPC Classes  ?

• G01N 15/1434 - Optical arrangements

Abstract

The invention concerns compounds which are useful in targeting and degrading the NUDT5 protein. The invention also concerns the compounds of the invention for use in methods of treatment, particularly for use in treatment of cancer, inflammatory disorders and folate-related disorders, as well as to reduce the side-effects and/or toxicity of a second drug. The invention further concerns screening methods.

IPC Classes  ?

• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders
• C07D 473/08 - Heterocyclic compounds containing purine ring systems with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
• A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir

Abstract

The present invention relates to a transducer for converting mechanical or kinetic energy to electrical energy, wherein the transducer comprises a composite material, wherein the composite material comprises a polymer matrix and, dispersed in the matrix, a metal organic framework (MOF), wherein the metal organic framework comprises a metal ion and an organic linker, wherein the organic linker comprises one or more electronegative substituents.

IPC Classes  ?

• H02N 1/04 - Friction generators
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material

Abstract

Disclosed is a method of processing input data in a processor. The method comprises providing a plurality of radio frequency (RF) signals, each comprising a plurality of RF frequencies with respective component values representing input data, and providing a plurality of optical signals, each optical signal having a respective optical frequency. Each optical signal is modulated with one of the RF signals to generate modulated optical signals. Processing operations are performed on the modulated optical signals in parallel to derive a processor output. Also disclosed is a processor for processing input data according to the method.

IPC Classes  ?

• G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data
• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means

Abstract

The invention provides methods for treating, preventing or reversing retinal degeneration. The methods administering to the subject a vector that expresses a Cadherin-related family member 1 (CDHR1) polypeptide. The invention also provides gene therapy vectors that expresses a CDHR1 polypeptide, host cells that express the gene therapy vectors, and pharmaceutical compositions comprising the gene therapy vector.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 27/02 - Ophthalmic agents
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

The invention relates to enhancing target pMHC discrimination of T cells by modulating the amount of expression and/or activity of factors associated with T cell receptor (TCR) kinetic proofreading.

IPC Classes  ?

• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 15/86 - Viral vectors

Abstract

The present invention relates to a polypeptide that forms one part of a two-part linker in which the polypeptide spontaneously forms an isopeptide bond with a peptide tag, the second part of the two-part linker. Nucleic acid molecules encoding the polypeptide, vectors comprising said nucleic acid molecules, and host cells comprising said vectors and nucleic acid molecules are also provided. A kit comprising said two-part linker (i.e. peptide tag and polypeptide binding partner), and/or nucleic acid molecules/vectors is also provided. A method of producing the polypeptide and the uses of the polypeptide of the invention are also provided.

IPC Classes  ?

• C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C07K 1/14 - ExtractionSeparationPurification
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression