Painceptor Pharma Corporation

Canada

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IPC Class
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID] 6
C07D 471/04 - Ortho-condensed systems 6
A61P 25/00 - Drugs for disorders of the nervous system 5
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms 5
A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines 4
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Found results for  patents

1.

METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY

      
Application Number CA2008001685
Publication Number 2009/039635
Status In Force
Filing Date 2008-09-24
Publication Date 2009-04-02
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Dube, Gilles
  • Gan, Zhonghong
  • Gill, Nachhattarpal
  • Cui, Xilin

Abstract

Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

IPC Classes  ?

  • C07D 209/46 - Iso-indolesHydrogenated iso-indoles with an oxygen atom in position 1
  • A61K 31/4035 - Isoindoles, e.g. phthalimide
  • C07D 487/04 - Ortho-condensed systems
  • A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
  • A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
  • C07D 213/69 - Two or more oxygen atoms
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
  • C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
  • C07D 471/06 - Peri-condensed systems
  • C07D 471/16 - Peri-condensed systems
  • C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings

2.

QUINOLINE AND QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF GATED ION CHANNELS

      
Application Number CA2008001208
Publication Number 2009/000085
Status In Force
Filing Date 2008-06-27
Publication Date 2008-12-31
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Dube, Gilles
  • Wei, Chang-Qing
  • Gan, Zhonghong
  • Ntirampebura, Deogratias
  • Brochu, Jean-Louis
  • Paquet, Michel
  • Elagoz, Aram

Abstract

Disclosed are compounds that modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include compounds of the Formulae 1, 2, 3, 4, and 5.

IPC Classes  ?

  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • A61K 31/47 - QuinolinesIsoquinolines
  • A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
  • A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
  • A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
  • A61P 13/00 - Drugs for disorders of the urinary system
  • C07D 215/42 - Nitrogen atoms attached in position 4
  • C07D 239/94 - Nitrogen atoms
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

3.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2008001047
Publication Number 2008/144931
Status In Force
Filing Date 2008-05-30
Publication Date 2008-12-04
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Dube, Gilles
  • Gan, Zhonghong

Abstract

The present invention is directed towards radiolabelled ASIC imaging agents of formula (I) as well as metabolites of ASIC antagonists under formula (III) wherein n can be 0 or 1. These compounds are useful for the diagnosis and treatment of diseases or disorders related to the activity of gated ion channels, namely neurological disorders, pain and inflammatory disorders.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
  • A61K 31/5395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
  • A61K 49/00 - Preparations for testing in vivo
  • A61K 51/04 - Organic compounds
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • A61P 35/00 - Antineoplastic agents
  • C07D 498/04 - Ortho-condensed systems

4.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2007000594
Publication Number 2007/115408
Status In Force
Filing Date 2007-04-10
Publication Date 2007-10-18
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Wei, Chang-Qing
  • Gan, Zhonghong
  • Demnitz, Joachim
  • Ahring, Philip, K.

Abstract

The alleged invention relates to indole derivatives according to formula 1, namely, wherein X is CH2, O, NR2 or NOR2 and wherein A is preferably a six membered ring involving a nitrogen heteroatom. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine
  • A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines

5.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2007000596
Publication Number 2007/115410
Status In Force
Filing Date 2007-04-10
Publication Date 2007-10-18
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Gan, Zhonghong
  • Wei, Chang-Qing
  • Price, Stephen
  • Dyke, Hazel, Joan
  • Dechaux, Elsa, Amandine

Abstract

The present invention relates to compounds of the Formula (I),(II), (III), (IV) or (V) useful to modulate the activity of gated ion channels. The invention further relates to methods wherein said compounds are used to modulate gated ion channels comprised of at least one subunit which is a member of the DEG/ENaC, P2X or TRPV gene superfamilies. The activity of the gated ion channels which are modulated by compounds I-V are associated with pain, inflammatory disorders or neurological disorders.

IPC Classes  ?

  • C07D 217/04 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ringAlkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
  • A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine
  • A61K 31/4725 - Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
  • A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
  • A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
  • C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond

6.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2007000580
Publication Number 2007/115403
Status In Force
Filing Date 2007-04-10
Publication Date 2007-10-18
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Demnitz, Joachim
  • Ahring, Philip, K.

Abstract

Polycyclic piperidine derivatives according to formulae (I) and (II): wherein the dashed lines independently represent a single or double bond. The substituents R1 to R7 in formula I are each selected from a range of functional groups. In formula II, R1 is C1-4 alkyl, R2 is H or OH, R3 is O or NR9, with R9 being selected from a range of functional groups, R4 and R5 are H or form together a single bond, and R6, R7, and R8 are each independently H or OH. The compounds and their pharmaceutically acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, and for treating diseases associated with the genitourinary or gastrointestinal system

IPC Classes  ?

  • C07D 217/22 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
  • A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
  • A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
  • A61K 31/4523 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
  • A61K 31/47 - QuinolinesIsoquinolines
  • A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
  • A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
  • A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • C07D 217/26 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
  • C07D 221/06 - Ring systems of three rings
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • C07D 471/04 - Ortho-condensed systems
  • C07D 471/14 - Ortho-condensed systems

7.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2007000595
Publication Number 2007/115409
Status In Force
Filing Date 2007-04-10
Publication Date 2007-10-18
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Gan, Zhonghong
  • Price, Stephen
  • Dyke, Hazel, Joan

Abstract

Indole derivatives according to formula (I), (II) or (III) wherein R1 is a hydrogen atom, an alkyl or alkoxy group and X-Y together with their adjacent carbon atoms form a six membered ring involving a nitrogen heteroatom or not. These compounds and their pharmaceutically acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

8.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2006002105
Publication Number 2007/071055
Status In Force
Filing Date 2006-12-21
Publication Date 2007-06-28
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Babinski, Kazimierz
  • Brochu, Jean-Louis
  • Ntirampebura, Deogratias
  • Wei, Chang-Qing
  • Zamboni, Robert, Joseph
  • Reayi, Ayub, A.

Abstract

Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4- position via N(H), C(O) or O moieties.

IPC Classes  ?

  • C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
  • A61K 31/47 - QuinolinesIsoquinolines
  • A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
  • A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
  • A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
  • C07D 215/52 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
  • C07D 239/74 - QuinazolinesHydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
  • C07D 239/88 - Oxygen atoms
  • C07D 239/91 - Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
  • C07D 239/94 - Nitrogen atoms
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

9.

COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS

      
Application Number CA2006001897
Publication Number 2007/059608
Status In Force
Filing Date 2006-11-22
Publication Date 2007-05-31
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Vohra, Rahul
  • Demnitz, Joachim
  • Ahring, Philip, K.
  • Gan, Zhonghong
  • Gill, Nachhattarpal

Abstract

Pyrrolo-isoquinoline compounds according to formula (I) wherein R3 is preferably a hydroxy radical and the southern ring is preferably a phenyl ring. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines

10.

METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY

      
Application Number CA2006001510
Publication Number 2007/030934
Status In Force
Filing Date 2006-09-14
Publication Date 2007-03-22
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Babinski, Kazimierz
  • Vohra, Rahul
  • Cui, Xilin
  • Auld, Daniel, Scott

Abstract

The current application discloses methods of modulating the interaction of nerve growth factor, or precursors thereof, with neurotrophin receptors by contacting cells expressing a neurotrophin receptor with a benzo-phenantroline core structure compound. The compounds involved in these methods are the ones of formulae (16-22). Also claimed and disclosed are specific compounds of formulae (16-21),of which formulae (16) and (21) are herein given as a chemical core type-structure of the disclosed compounds.

IPC Classes  ?

  • C07D 471/04 - Ortho-condensed systems
  • A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine

11.

METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY

      
Application Number CA2006001517
Publication Number 2007/030940
Status In Force
Filing Date 2006-09-14
Publication Date 2007-03-22
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Babinski, Kazimeriz
  • Vohra, Rahul
  • Cui, Xilin
  • Auld, Daniel, Scott
  • Gill, Nachhattarpal

Abstract

Disclosed are compounds and pharmaceutically acceptable compositions thereof which modulate the interaction between nerve growth factor and precursors thereof and neurotrophm receptors and treat disease conditions mediated therefrom such as pam, inflammatory disorders and neurological disorders Also disclosed are methods of using the compounds and compositions of the invention, including methods of administration The compounds have the following structural formula wherein m and n are independently 0 or 1 , x and y are independently 0 or 1, provided that n and y are not 0 at the same time, and the substituents R1-R5, Rloand R11 are further defined in the Formula (I).

IPC Classes  ?

  • C07D 221/06 - Ring systems of three rings
  • C07D 209/90 - Benzo [c, d] indolesHydrogenated benzo [c, d] indoles
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
  • A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

12.

METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY

      
Application Number CA2006001516
Publication Number 2007/030939
Status In Force
Filing Date 2006-09-14
Publication Date 2007-03-22
Owner PAINCEPTOR PHARMA CORPORATION (Canada)
Inventor
  • Babinski, Kazimierz
  • Vohra, Rahul
  • Cui, Xilin
  • Auld, Daniel, Scott
  • Gill, Nachhattarpal

Abstract

Disclosed are compounds and pharmaceutically acceptable compositions thereof which modulate the interaction between nerve growth factor and precursors thereof and neurotrophm receptors and treat disease conditions mediated therefrom such as pam, inflammatory disorders and neurological disorders Also disclosed are methods of using the compounds and compositions of the invention, including methods of administration The compounds have the following structural formula wherein m and n are independently 0 or 1 , x and y are independently 0 or 1, provided that n and y are not 0 at the same time, and the substituents R1-R5, R10 and R11 are further defined

IPC Classes  ?

  • C07D 221/06 - Ring systems of three rings
  • C07D 221/14 - Aza-phenalenes, e.g. 1,8-naphthalimide
  • C07D 209/90 - Benzo [c, d] indolesHydrogenated benzo [c, d] indoles
  • C07D 209/92 - Naphthostyrils
  • C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
  • C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 413/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
  • C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
  • A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
  • A61P 25/00 - Drugs for disorders of the nervous system
  • A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]