03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Toiletries. Pharmaceuticals and natural remedies; Diagnostic preparations and materials; Live organs and tissues for surgical purpose; Medical dressings, coverings and applicators; Activated charcoal for adsorption of toxins for medical purposes; Medicinal alcohol; Alcohol for pharmaceutical purposes; Amino acid preparations for medical purposes; Amino acid preparations for veterinary use. Scientific research and laboratory apparatus, educational apparatus and simulators. Medical and veterinary apparatus and instruments.
2.
Laser-assisted intradermal administration of active substances
A vaccine preparation comprising an antigen for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, wherein the antigen is linked to a binder of a dermal migratory antigen-presenting cell (APC); and a pharmaceutical preparation comprising an active substance for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, for regional delivery to a target location. The invention further relates to the laser-assisted intradermal administration of antigens accompanied by repeated chemotherapy.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
3.
LASER-ASSISTED INTRADERMAL ADMINISTRATION OF ACTIVE SUBSTANCES
A vaccine preparation comprising an antigen for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser- generated micropores, wherein the antigen is linked to a binder of a dermal migratory antigen-presenting cell (APC); and a pharmaceutical preparation comprising an active substance for use in the prophylactic or therapeutic treatment of a subject by intradermal administration through laser-generated micropores, for regional delivery to a target location. The invention further relates to the laser-assisted intradermal administration of antigens accompanied by repeated chemotherapy.
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
The invention relates to an assembly comprising an amplifying laser material (1) and a cooling unit (7), which cooling unit has a cavity (13) for accommodating at least part of the laser material (1), wherein a metal (21) is in a gap between the laser material (1) and the cooling unit (7), which metal is liquid at least during operation of the assembly and serves to transfer heat from the laser material (1) to the cooling unit (7). At least one channel (14), in which a metal (21) that is liquid at least during operation of the assembly is located at least in an end segment (22) adjoining the cavity (13), leads away from the cavity (13) accommodating the laser material (1).
H01S 3/06 - Construction or shape of active medium
H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
5.
SKIN CONTACT DETECTING DEVICE FOR A DEVICE TO BE SECURED
The invention relates to a skin contact detecting device (1) for a device (24) to be secured, comprising a contact piece (2) with a bearing surface (3) and comprising a securing circuit (7) with a light source (6), a photodetector (9), and an analyzing circuit (17). The bearing surface (3) has a light outlet portion (4) and a light inlet portion (5) which is delimited by the light outlet portion. Furthermore, the light source (6) has a main beam direction (8) of the emitted electromagnetic radiation, said main beam direction being oriented in the direction of the light outlet portion (4). The photodetector (9) has a detecting region (10) for electromagnetic radiation, said detecting region being oriented in the direction of the light inlet portion (5). The light source (6) is designed to emit light of a first (13) and at least one second (14) wavelength, and the photodetector (9) is sensitive to the first (13) and the second (14) wavelength. The analyzing circuit (17) has a database (43) in which reference data sets (41, 42) comprising reference data for detected first (39) and second (40) signals are stored. Furthermore, the analyzing circuit (17) has a comparator circuit (19), said comparator circuit (19) being designed to compare a detected first (39) and second (39) wavelength with the reference data sets (41, 42) stored in the database (43) and to emit a secure operating state signal (22).
H01S 3/14 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range characterised by the material used as the active medium
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
H01S 3/042 - Arrangements for thermal management for solid state lasers
H01S 3/06 - Construction or shape of active medium
A monolithic, side pumped solid-state laser (1) comprising a laser resonator structure (3) comprised of a laser gain medium (2) having a longitudinal axis (L), wherein the laser resonator structure (3) comprises end faces (4) forming a linear optical path resonant cavity there between, at least one of the end faces (4) comprising at least partially reflecting laser mirrors (4a, 4b) in particular deposited thereon, the laser gain medium (2) comprising a side face (2a) for receiving pump light (5a) of a pump source (5), wherein the pump light (5a) is generated by a diode laser (5), and comprising a conductive cooler (6) comprising contact faces (6c) contacting the laser gain medium (2), and comprising a reflector (7) arranged opposite to the side face (2a) with respect to the longitudinal axis (L), wherein the laser gain medium (2) is a low gain material.
H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
H01S 3/06 - Construction or shape of active medium
H01S 3/042 - Arrangements for thermal management for solid state lasers
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
8.
MONOLITHIC, SIDE PUMPED SOLID-STATE LASER AND METHOD FOR OPERATING THE SAME
A monolithic, side pumped solid-state laser (1) comprising a laser resonator structure (3) comprised of a laser gain medium (2) having a longitudinal axis (L), wherein the laser resonator structure (3) comprises end faces (4) forming a linear optical path resonant cavity there between, at least one of the end faces (4) comprising at least partially reflecting laser mirrors (4a, 4b) in particular deposited thereon, the laser gain medium (2) comprising a side face (2a) for receiving pump light (5a) of a pump source (5), wherein the pump light (5a) is generated by a diode laser (5), and comprising a conductive cooler (6) comprising contact faces (6c) contacting the laser gain medium (2), and comprising a reflector (7) arranged opposite to the side face (2a) with respect to the longitudinal axis (L), wherein the laser gain medium (2) is a low gain material.
H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
H01S 3/06 - Construction or shape of active medium
H01S 3/042 - Arrangements for thermal management for solid state lasers
9.
Laser device and method for ablating biological tissue
x) configured to modify the laser beam (4) such as to direct the laser beam (4) on the biological tissue (1); d) a controller (11) that is configured to control the laser source (7) to emit the laser beam (4) to create an ablation in biological tissue (1), whereby e) a sensor (19) being configured to receive back scattered light from the biological tissue (1); f) a tissue controller (18) that is operationally coupled to the sensor (19) to receive a sensor signal (Ri) of the sensor (19); and g) the tissue controller (18) being configured to compare a series of at least two consecutive sensor signals (R1, R2, R3, . . . ) and being configured to generate a tissue control signal (TCS) when the value of the series of consecutive sensor signals (R1, R2, R3, . . . ) decreases in a predetermined amount.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
10.
APPARATUS AND METHOD FOR THE DEFLECTION OF ELECTROMAGNETIC RADIATION, IN PARTICULAR OF A LASER BEAM
The deflection apparatus (1) for the deflection of electromagnetic radiation, in particular of a laser beam, includes a drive apparatus (2) and includes a beam deflection apparatus (4), in particular a mirror (4), which is arranged with the drive device (2) such that the drive apparatus (2) determines the alignment of the beam deflection apparatus (4), and includes a friction apparatus (5) which is arranged and made such that it brings about static friction or sliding friction onto the movably journaled beam deflection apparatus (4), with the drive apparatus (2) being made such that it can generate a drive force which overcomes the static friction, and includes a control apparatus (10) for the control of the drive apparatus (2).
G02B 6/08 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres the relative position of the fibres being the same at both ends, e.g. for transporting images with fibre bundle in form of plate
11.
LASER DEVICE AND METHOD FOR ABLATING BIOLOGICAL TISSUE
A laser device (10) for ablating a biological tissue (1), comprising: a) a laser source (7) that is configured to emit a laser beam (4); b) optics (8a,8b,8x) configured to modify the laser beam (4) such as to direct the laser beam (4) on the biological tissue (1); d) a controller (11) that is configured to control the laser source (7) to emit the laser beam (4) to create an ablation in biological tissue (1), whereby e) a sensor (19) being configured to receive back scattered light from the biological tissue (1); f) a tissue controller (18) that is operationally coupled to the sensor (19) to receive a sensor signal (Ri) of the sensor (19); and g) the tissue controller (18) being configured to compare a series of at least two consecutive sensor signals (R1,R2,R3,...) and being configured to generate a tissue control signal (TCS) when the value of the series of consecutive sensor signals (R1,R2,R3,....) decreases in a predetermined amount.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
12.
LASER DEVICE AND METHOD FOR ABLATING BIOLOGICAL TISSUE
A laser device (10) for ablating a biological tissue (1), comprising: a) a laser source (7) that is configured to emit a laser beam (4); b) optics (8a, 8b, 8x) configured to modify the laser beam (4) such as to direct the laser beam (4) on the biological tissue (1); d) a controller (11) that is configured to control the laser source (7) to emit the laser beam (4) to create an ablation in biological tissue (1), whereby e) a sensor (19) being configured to receive back scattered light from the biological tissue (1); f) a tissue controller (18) that is operationally coupled to the sensor (19) to receive a sensor signal (Ri) of the sensor (19); and g) the tissue controller (18) being configured to compare a series of at least two consecutive sensor signals (R1, R2, R3,...) and being configured to generate a tissue control signal (TCS) when the value of the series of consecutive sensor signals (R1, R2, R3,....) decreases in a predetermined amount.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical and veterinary preparations;
chemical-pharmaceutical preparations; chemical preparations
for pharmaceutical purposes; chemical preparations for
medical purposes, pharmaceutical preparations and
substances; medicines for human and veterinary purposes;
bacteriological and biological preparations for medical or
veterinary purposes; bacterial preparations for medical or
veterinary purposes; diagnostic agents for medical purposes;
adhesive tapes and adhesive strips for medical purposes;
plasters for medical purposes; transdermal patches. Computer software for the operation of and treatment with
medical and aesthetic laser, energy delivery and energy
emitting devices. Surgical, medical, dental and veterinary instruments and
apparatus; medical apparatus and instruments; apparatus,
plasters and containers for the dispensing of medicines;
transdermal medicine administration apparatus; analysis
apparatus for medical purposes such as blood, cell,
substance, molecular analysis or cell separation apparatus;
iontophoretic apparatus and intradermal apparatus; apparatus
for the perforation or for the removal of skin, tissue or
organs; diagnostic apparatus for medical purposes;
electrodes and probes for medical purposes; lasers and laser
apparatus for medical and aesthetic purposes; medical and
aesthetic energy delivery or energy emitting devices, namely
electromagnetic radiation apparatus; associated medical and
aesthetic equipment for the laser, energy delivery and
energy emitting devices, namely monitors, display screens,
hand pieces, tips, hand piece tips, disposable tips; special
cases for medical instruments.
14.
WIDE-AREA PARASYSTEMIC TREATMENT OF SKIN RELATED CONDITIONS
Use of an immunomodulatory, immunostimulatory, or immunosuppressive drug in the manufacture of a medicament for treatment of a skin related disease or disorder, wherein the drug is formulated for topical administration to porated skin having a plurality of pores with predetermined geometry such that the concentration of the drug in combination with the predetermined geometry of the pores are effective in treatment of the skin related disease or disorder. The method of facilitating treatment of a skin related disease or disorder, comprising providing information that a drug is effective in treatment of the skin related disease or disorder; providing information to apply the drug to an area of porated skin comprising a plurality of pores; wherein the information specifies that the area is equal or greater than 1 cm2; wherein the information further specifies that at least some of the plurality of pores have a predetermined geometry; and wherein the predetermined geometry is effective to substantially prevent systemic administration of the drug.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A tip (8) comprising a first portion (8r) that is configured to be removably coupled to a laser porator (10) and a second portion (8h) defining an aperture (8x) and comprising a tissue biasing element (8a) that is configured to deform at least a portion (1a) of a tissue (1) that is subject to a laser treatment.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
16.
TRANSDERMAL DELIVERY SYSTEM FOR TREATING INFERTILITY
The transdermal delivery system for treating infertility in a patient comprises an apparatus (10) for facilitating transdermal delivery of a drug (5a) through an area of the skin of the patient, wherein the apparatus (10) comprises an ablator that is configured to generate a microporation in the area of the skin of the patient, and comprises a drug (5a), wherein the drug effects at least one of the biological regulation of at least one oocyte containing follicle, stimulation of follicle growth, induction of ovulation, promotion of gestational status, maintenance of conceptus, maintenance of pregnancy.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61N 1/30 - Apparatus for iontophoresis or cataphoresis
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
17.
A SYSTEM FOR TRANSMEMBRANE ADMINISTRATION OF A PERMEANT
A system for transmembrane administration of a permeant, the system comprising: a) at least one permeant (5a), b) data of at least one initial microporation dataset (D) for the at least one permeant (5a), c) and a micro-porator (10) configured to porate a biological membrane (1) as defined by the initial microporation dataset (D).
A61K 9/00 - Medicinal preparations characterised by special physical form
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4), the laser source (7) comprising a laser diode (7c); b) optics (8a,8b,8x) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; d) a laser beam shaping device that reshapes the energy intensity distribution of the laser beam (4); and e) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) in the biological membrane (1).
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
19.
MICROPORATOR FOR PARATING A BIOLOGICAL MEMBRAN AND INTEGRATED PERMEANT ADMINISTERING SYSTEM
A micro-porator (10) for porating a biological membrane (1), comprising: a) a controller (11) b) an initial microporation dataset (D); c) and an ablator (10a) for creating a microporation on the biological membrane (1), the controller (11) controlling the ablator (10a) based on the initial microporation dataset (D), to create the microporation as defined by the initial microporation dataset (D).
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
There is disclosed a method for creating an initial permeation surface (A) in a biological membrane (1) comprising: a) creating a plurality of individual micropores (2i) in the biological membrane (1), each individual micropore (2i) having an individual permeation surface (Ai); and b) creating such a number of individual micropores (2i) and of such shapes, that the initial permeation surface (A), which is the sum of the individual permeation surfaces (Ai) of all individual micropores (2i), having a desired value. A Microporator performing the method is also disclosed.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
The laser micro-porator (10) for porating a biological membrane (1), comprises: a) a laser source (7) that emits a pulsed beam (4); b) optics (8a,8b) that modify the pulsed beam to direct a laser beam (4) of less that 1 mm width on the biological membrane (1); c) a deflector (8f) oriented to direct the laser beam (4) in various directions; and d) a poration controller (11) that controls the laser source (7) to create a poration consisting of a plurality of individual pores (2) on the biological membrane (1).
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
