Disclosed herein are methods and compositions for identifying domestic livestock having a motor impairment by identifying a motor impairment (MI) haplotype or genotype in the animal. In some embodiments, the methods are used in a selective breeding and mating program, and in some embodiments, the animal is a Holstein bovine, Holstein crossbred, or bovine of another breed with Holstein ancestry.
C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
2.
ARTICLES AND METHODS FOR GENERATING TUNABLE COLORATION AND INTERFERENCE UPON REFLECTION OF INCIDENT ELECTROMAGNETIC RADIATION
Disclosed are articles, embodiments, and methods of formation related substrates which exhibit a tunable interference pattern (e.g., structural color) upon reflection of incident electromagnetic radiation.
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
3.
A Novel Poultry Salmonella Vaccine and Diagnostic Methodology to Control Foodborne Salmonellosis
University of Florida Research Foundation, Incorporated (USA)
THE PENN STATE RESEARCH FOUNDATION (USA)
Inventor
Kariyawasam, Subhashinie
Wijetunge, Dona Saumya Sewwandi
Abstract
A vaccine for treating Salmonella enteriditis that includes an immunogenically effective amount of a Salmonella enteritidis protein InvG, and optionally a pharmaceutically acceptable carrier is described. Methods of using compositions that include the Salmonella Enteritidis protein InvG or a delivery vector that expresses Salmonella Enteritidis protein InvG for immunizing poultry against Salmonella Enteritidis are also described.
C12N 15/70 - Vectors or expression systems specially adapted for E. coli
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
4.
LANTHANIDE-TEMPLATED PROTEIN DIMERIZATION AND FINER RARE EARTH SEPARATION
Provided are proteins and peptides suitable for binding lanthanide ions and/or actinide ions. Proteins of the present disclosure may contain or be one of the following sequences: DDKAACAX1GIAAVKAX2VEKLAPEAVPQKLKRALKIAEREQGEGX3FX4X5CLX6ALX7DAKRALPKX8X9(SEQ ID NO:1) or MMRTRTSLAVPRGFRGSALLADDKAACAX1GIAAVKAX2VEKLAPEAVPQKLKRALKIAEREQGEGX3FX4X5CLX6ALX7DAKRALPKX8X9(SEQ ID NO:52), where X1is D or S; X2is R or K; X3is E, Q, or M; X4is D, N, Q, or K; X5E, N, Q, D, A, or T; X6is E, A, or Q; X7is D or E; X8is Y, W, or absent; and X9is G or absent, or a protein having at least 70% identity to SEQ ID NO:1 or 52. Proteins or peptides of the present disclosure may contain a metal-binding motif or be REX1X2EX3EX4DEC (SEQ ID NO:53), where X1is any amino acid; X2is any amino acid, (e.g., G, A, K, R); X3is any amino acid, (e.g., G, A, or K); and X4 is F or Y; and the C forms a disulfide bond with another cysteine residue elsewhere in the peptide. Also provided are methods of using any one of the proteins or peptides, methods of making any one of the proteins or peptides, and kits.
G02B 1/02 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of crystals, e.g. rock-salt, semiconductors
G02F 1/03 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect
6.
FUNCTIONAL PICKERING EMULSIONS AND METHODS FOR MAKING AND USING THE SAME
Embodiments relate to polysaccharides such as amphiphilic hairy cellulose nanocrystals and methods of making and using thereof. The amphiphilic hairy cellulose nanocrystals may dually function as a versatile Pickering stabilizer and as an antiscalant. The amphiphilic hairy cellulose nanocrystals may include hydrophobic alkyl chains and hydrophilic carboxylate groups anchored onto protruding disordered cellulose chains of cellulose bodies. Other groups, such as cationic and/or electrically neutral groups, can be anchored onto protruding disordered chains to impart additional functionality.
A nucleic acid testing device includes a microfluidic cartridge, an analyzer and a processing unit for controlling the analyzer. The microfluidic cartridge includes a binding chamber, a washing chamber and a reaction chamber. The analyzer includes a mechanical module including an electromagnetic coil array and a permanent magnet. The electromagnetic coil array is programmed to generate a programmable pulsed electromagnetic field to actuate the permanent magnet that further controls a paramagnetic bead (PMB) assay in the cartridge to move among the adjacent chambers.
A battery includes an electrolyte, a metal anode and a cathode. The metal anode includes a porous material disposed thereon to protect the metal anode. The porous material has a zeta potential with a magnitude of at least above 15 mV in the electrolyte. The porous material can include a cross-linked polymer having segments with polar functional groups. Examples of polar functional groups include, but are not limited to, those comprising one or more among O, N, P, S, and B.
The disclosed method utilizes chemical-free ozone oxidative precipitation for the recovery of dissolved (such as Co, Mn, Ni, Cu, Ag, Cd, Zr, Ce, Os, Ir, Pd, Pt, Rh, Ru, Cr, Fe, Bi, Ga, Sn, and/or Tl) metal ions from aqueous solutions. The aqueous solutions could be mine or industrial influenced water or leachate obtained by processing primary or secondary sources of the elements. The process selectively separates these elements from aqueous streams and may be utilized in purification processes. The target elements are recovered without pH adjustment by chemicals, or using expensive oxidizers, thereby minimizing the process cost, chemical consumption, and environmental footprints. In acidic and circumneutral solutions, these elements can be recovered as solid precipitates. In alkaline solutions, these elements will be recovered again as solid precipitates.
A prosthetic anastomosis fixation device comprising an inner support structure and an outer support structure positioned around the inner support structure and coupled to a prosthetic device, wherein the inner support structure comprises an expandable structure radially movable between an unexpanded to an expanded configuration, wherein in the expanded configuration, the inner support structure provides a radially outward force toward an inner surface of the outer support structure, wherein the inner and outer support structures are sized and configured to receive a portion of a biological conduit therebetween such that in the expanded configuration, the portion of a biological conduit is fixedly secured between the inner surface of the outer support structure and an outer surface of the inner support structure.
A prosthetic anastomosis fixation device comprising an inner sleeve sized and configured to be received within a blood vessel of a patient, the inner sleeve including a projection (e.g., pins) extending from an outer surface of the inner sleeve and a groove provide on the outer surface spaced apart from the projection, and a fixation ring removably received over the inner sleeve, wherein engagement between the projection and the fixation ring couples the fixation ring to the inner sleeve.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
12.
FIBER OPTIC FLOW METER FOR HIGH TEMPERATURE CORROSIVE NUCLEAR ENVIRONMENTS
Embodiments can relate to a flow meter. The flow meter includes a tube having a length L. The flow meter includes a heater wire either wound about the tube or extending through the tube. The flow meter includes an optical fiber extending through the tube. An interrogator is used to interrogate the optical fiber. Electrical power can be supplied to the heater wire. The flow meter is placed in an environment in which fluid (e.g., gas or liquid) is allowed to, caused to, or anticipated to flow over the tube in a direction that is not parallel to the length L of the tube.
G01F 1/688 - Structural arrangementsMounting of elements, e.g. in relation to fluid flow using a particular type of heating, cooling or sensing element
G01F 1/661 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters using light
13.
APPARATUS AND PROCESS FOR FRACTURE CONDUCTIVITY TUNING
Tuning fracture hydraulic conductivity can be provided so that high hydraulic conductivity in high temperature zones and low hydraulic conductivity in low temperature zones can be defined in enhanced geothermal systems (EGS). Uniform thermal gradient along flow paths can be provided or defined to help provide such conductivity zones. Experimentation performed to evaluate embodiments showed that embodiments could prevent appearance of dominant flow paths between the wells and maintain high heat extraction rates. Embodiments can greatly increase cumulative heat extraction. Embodiments can also be provided for application solely to the injection wells. Other embodiments can position tuning agents between the wells and still help provide control of the fluid flow in the reservoir and enhance heat extraction.
A frangible and degradable apparatus for seed protection and seedling growth can include a housing comprised of at least one biodegradable material. The housing can include frangible spaced apart fingers that define slots that are in communication with an inner chamber defined by the fingers. Distal ends of the fingers can define an end aperture in communication with the inner chamber. In some embodiments, one or more offset apertures can also be defined by portions of immediately adjacent fingers. The fingers as well as other portions of the housing can break off from the housing via force provided by the growing stem and root of the seedling that grows from the seed to increase a rate at which the finger and other portions can biodegrade underground. The fingers can also be perforated in some embodiments.
Embodiments can relate to techniques for recycling metals from electronic waste (e.g. waste printed circuit boards (WPCBs), consumer electronics, industrial electronics, etc.). Specifically, embodiments can relate to a method for processing product to liberate target materials within that product in an optimized manner. An exemplary method can involve generating a mix by subjecting the product to one or more comminution techniques to reduce one or more components of the product to particles having, on average, a predetermined size, and then subjecting the particles to additional comminution and/or separation techniques. The first round of comminution used to reduce the components to the predetermined size can lead to greater efficiencies and optimized liberation of target materials.
Embodiments relate to graphene composite electrodes and methods of making thereof. The graphene electrode composites are formed from graphene oxide liquid crystal precursors and exhibit a scaffolding structure configured to host electrode active material. The graphene composite electrodes exhibit practical capacity retention, high Coulombic efficiency, and long cycling stability.
Embodiments relate to structures formed from shape memory polymers and methods of making thereof. A structure is formed from at least one UV curable shape memory polymer resin and includes a plurality of domains. Each domain corresponds to a different region of the structure cured via a different UV light exposure time. The structure is configured to transform from a temporary shape to an established shape upon being stimulated by an external stimulus.
F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
18.
SOLUTION SPINNING OF PROTEIN-CELLULOSIC BLEND FIBERS
Provided are compositions and methods related to cellulosic materials combined with protein powder and that are subjected to aging conditions under temperature during a process that includes wet spinning to produce fibers. The method yields mechanically strong fibers.
D01F 2/02 - Monocomponent artificial filaments or the like of cellulose or cellulose derivativesManufacture thereof from solutions of cellulose in acids, bases, or salts
D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
19.
SUPER-RESOLUTION THERMOREFLECTANCE THERMAL MEASUREMENT SYSTEM
A system and method for performing nanoscale thermal property characterization of materials. The system combines the operating principles of thermoreflectance-based techniques and scanning probe microscopy techniques into a hybrid solution capable of deriving thermophysical properties of a sample. A pump laser beam heats a distal end of a cantilever, and a probe laser beam is reflected off of a specular surface at the distal end of the cantilever carrying with it thermoreflectance data that can be used to extract thermophysical properties of the sample region adjacent to a tip suspended at the distal end of the cantilever.
A matching layer for an ultrasound imaging head includes a translucent matrix and a plurality of translucent particles (e.g, glass beads, etc.) disposed in the translucent matrix. A volume fraction of the plurality of translucent glass beads in the translucent matrix is selected to provide a predetermined acoustic impedance. The diameter of the glass beads of the plurality of glass beads may be selected to provide a predetermined acoustic impedance. The matching layer may be disposed on a transparent piezoelectric element. Such an arrangement may be configured for photoacoustic imaging. An illumination source may provide light to a region of interest, and the light may be transmitted at least partially through the transparent piezoelectric element and the matching layer.
Methods and systems facilitate measuring flow properties of a material, such as biomass materials, that include different material particles. Sample holding plates securely hold material particles and secure them to sample holders. A normal force actuator applies a normal force between material particles held by the sample holding plates and a sliding force actuator applies a sliding force. Normal and sliding force sensors monitor the transmitted forces, allowing a processor to determine adhesion and friction characteristics between particles held by the first and second sample holding plates.
G01N 3/10 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces generated by pneumatic or hydraulic pressure
G01N 3/24 - Investigating strength properties of solid materials by application of mechanical stress by applying steady shearing forces
G01N 33/483 - Physical analysis of biological material
22.
IMPROVING IMMUNE CELL-BASED THERAPIES AGAINST SOLID TUMORS WITH OPTOGENETICALLY ENGINEERED SEPTIN PROTEINS
A method for enhancing immune cell penetration into solid tumors, the method including at least one of the following: (a) obtaining a light-sensitive septin protein, the light-sensitive septin protein including a blue light-responsive domain, (b) transfecting an immune cell with the light-sensitive septin protein; and (c) periodically exposing the transfected immune cell to a blue light. Disclosed herein are also light-sensitive septin proteins that can be used for enhancing immune cell penetration into solid tumors.
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
23.
METHODS FOR PLANNING AND GUIDING ENDOSCOPIC PROCEDURES THAT INCORPORATE IMAGE-TO-BODY DIVERGENCE REDUCTION
A method for planning and guiding an endoscopic procedure is disclosed. The method includes obtaining a first scan of a chest cavity at near total lung capacity, obtaining a second scan of the chest cavity at near functional residual capacity, generating a virtual chest cavity based at least in part on the first scan and the second scan, defining one or more regions of interest (ROI) in the virtual chest cavity, and determining a route to the one or more ROIs based on the virtual chest cavity. The method includes directing endoscope hardware through an airway to the one or more ROIs along the predetermined route, monitoring, by a processor, a real-time position of the endoscope hardware relative to an expected position along the predetermined route, and performing an examination of the one or more ROIs when the real-time position of the endoscope hardware corresponds to an expected ROI location.
24.
Multi-destination procedure planning and guidance for endoscopic surgery
A method for planning a tour visiting a set of target diagnostic sites via endoscopy passing through a hollow organ system includes computing a 3D virtual space of the hollow organ system based on the 3D imaging scan depicting the diagnostic sites and hollow organ system, computing a series of preliminary endoscopic routes leading to each diagnostic site including a set of contiguous device poses through the hollow organ system that connect each target diagnostic site to all of the other target diagnostic sites, and computing an optimal tour having a minimum cost corresponding to the smallest set of contiguous poses that visit all of the target diagnostic sites once and only once, where the cost between each pair of diagnostic sites is defined as the distance accumulated by the smallest set of contiguous poses connecting the pair of diagnostic sites together within the hollow organ system.
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
Disclosed herein are methods and compositions for treating addiction disorder disorder, including opiod use disorder, in a subject in need thereof, the method including administering a combination therapy to the subject in need thereof, the combination therapy including (i) a therapeutically effective dosage of a glucagon-like peptide-1 (GLP-1) agonist, and (ii) a therapeutically effective dosage of an orexin-1 receptor antagonist, an orexin-2 receptor antagonist or a combination thereof.
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
The present disclosure is directed to nanocomposites comprising a co-sintered composition of a MXene crystal form composition and an inorganic oxide, or oxide-type ceramic and methods of making and using the same.
C04B 35/56 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on carbides
C04B 35/453 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zinc, tin or bismuth oxides or solid solutions thereof with other oxides, e.g. zincates, stannates or bismuthates
An end effector is provided. The end effector includes a frame, a reinforcing structure dispenser that is coupled to the frame and configured to discharge a plurality of elongate strands to form a strand pattern, and matrix dispenser that is coupled to the frame and includes a nozzle to discharge a matrix material on the strand pattern so that the plurality of elongate strands is at least partially embedded in the matrix material to achieve a reinforced bead. The end effector further includes a motor that is coupled to the frame and configured to actuate the reinforcing structure dispenser to rotate relative to the frame to achieve the strand pattern. The end effector includes a controller configured to control at least one of the reinforcing structure dispenser, the matrix material dispenser, or the motor.
This document relates to textiles. For example, textiles (e.g., water-repellent textiles) as well as methods for modifying textiles to alter one or more properties of the textiles are provided. In some cases, a textile can be modified to be more water-repellent and/or more oil-repellent. For example, a textile containing one or more cellulose fibers can be modified to have one or more charged (e.g., negatively charged) moieties on its surface, and the textile can subsequently be contacted with a surfactant (e.g., a cationic surfactant) to render the surface of the textile more hydrophobic (e.g., more water-repellent). For example, a textile containing one or more synthetic fibers can be produced to have one or more charged (e.g., negatively charged) moieties on its surface, and the textile can subsequently be contacted with a surfactant (e.g., a cationic surfactant) to render the surface of the textile more hydrophobic (e.g., more water-repellent).
29.
SELECTIVE MULTIPLEXED ELECTROCHEMICAL PLATFORM FOR DETECTION OF HIV INFECTION
The present application provides a multiplex detecting platform for diagnosing HIV infection in a subject, as well as methods for diagnosing HIV infection with the multiplex detecting platform described herein.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
The present disclosure relates to a method of reducing the occurrence of or preventing fire blight disease in a pome fruit tree. This method involves applying a non-transgenic Erwinia amylovora strain comprising one or more auxotrophic mutations to a pome fruit tree growing in a field under conditions effective to reduce the occurrence of or prevent fire blight disease. The present disclosure also relates to an agricultural composition comprising a non-transgenic Erwinia amylovora strain comprising one or more auxotrophic mutations and an agriculturally acceptable carrier.
Disclosed herein are recombinant poly nucleotides and universal stem cells comprising said recombinant polynucleotides. Also disclosed herein are method for treating cardiac disorders using the universal stem cells comprising said recombinant polynucleotides.
Embodiments relate to an adsorbent comprising an aminated solid support functionalized with at least one catechol-based compound, such as catechol, nitro-catechol, and/or pyrogallol. The adsorbent may be configured to be used for germanium recovery from dilute acidic sources. The adsorbents may be synthesized using microwave radiation. Embodiments further relate to methods of using catechol-based adsorbents, particularly to using adsorbents in fixed-bed columns for germanium adsorption.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
Glass compositions, which can provide glass that can be formed with a reduced carbon footprint. Some embodiments of the glass can include between about 1.5 mole percent (mol %) alumina (Al2O3) and 5 mol % Al2O3 and between 5 mol % silica (SiO2) and 45 mol % SiO2 and between 35 mol % phosphorus pentoxide (P2O5) and 50 mol % of P2O5. Embodiments can also include modifiers. Embodiments can also include coloration agents or other elements. The glass compositions can be used to make different types of glass articles.
A method of fabricating a composite material can include adding particulate material to an elastomeric material. The particulate material can include expanded graphite particulates and/or graphite nanoplatelet particulates. The particulate material can be diffused within the elastomeric material to uniformly disperse the particulate material within the elastomeric material. The elastomeric material having the particulate material dispersed therein can then be cured after the diffusing to form a structure comprised of the composite material, the composite material including the elastomeric material and the particulate material. In some embodiments, surfaces of the particulate material can be modified to include carboxyl and hydroxyl groups before the particulate material is added to the elastomeric material to facilitate improved bonding of the particulate material. In some embodiments, the formed structure can be configured as or for use in a gasket, seal, vibration dampening device or sound reduction device.
A sound absorbing panel includes a cavity section having a plurality of resonant cavities and a front panel having a plurality of sets of openings. Each set of openings is configured to provide fluid communication between one of the plurality of resonant cavities and the environment. Each of the plurality of resonant cavities has different dimensions from the remaining plurality of resonant cavities such that each of the resonant cavities is tuned for a different frequency range. Each of the sets of openings can differ from the remaining sets of openings in opening size, length, and distance between openings.
Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
37.
ENHANCED NANOENERGETIC METALS VIA IN SITU REDUCTION OF NATIVE OXIDE LAYER
Disclosed are methods for producing metallic nanoparticles that are: (1) nearly free of oxide; (2) coated with a passivating layer that prevents re-oxidation; (3) decomposes during combustion; and/or (4) improves combustion of the metal. Embodiments involve reduction or removal of native oxide on the surface of metal nanoparticles by treatment in hydrogen plasma at low pressure (e.g., glow discharge). In the alternative, some embodiments involve generating a mechanical blend of nanoparticle metals to remove or reduce native oxide on the surface of metal nanoparticles. After reduction or removal of native oxide, the resultant nanoparticle metal or nanoparticle metal blend can be coated to prevent re-oxidation. This can involve deposition of a fluorocarbon film on the nanoparticle metal or nanoparticle metal blend.
In one aspect, compositions are described herein, and in another aspect methods are described herein. In some embodiments, a polymerizable composition described herein comprises (i) one or more alkoxylated or alkenoxylated, or non-alkoxylated and non-alkenoxylated, citric acid, citrate, or ester/amide of citric acid; (ii) a polyol or polyamine such as a diel or diamine; and (iii) at least one of an associated or dissociated salt comprising a monovalent, divalent, or trivalent metal cation. In some cases, the polymerizable composition comprises additional monomers. In some cases, a composition described herein comprises a polymer or oligomer formed from a polymerizable compositions described herein. In other instances, a self-setting composite material comprising a mixture of a metal oxide crosslinker and a citrate based polymer, as well as methods of preparing same, are described herein.
A method of counting target salivary miRNAs related to mild traumatic brain injury (mTBI) includes the steps of binding the miRNAs to padlock probes specific to each miRNA forming a hybridized complex for each miRNA, ligating the hybridized complex forming a closed circular structure, elongating the hybridized complex producing an elongated ssDNA amplicon via rolling circle amplification (RCA) elongation, measuring the concentration of elongated ssDNA amplicon according to a translocation event rate using a solid-state pore structure with a diameter greater than 10 nm, and determining initial concentrations of miRNAs based on the quantity of the initial miRNA molecule which is linear with the concentration of elongated ssDNA amplicon.
Disclosed herein is a device comprising: a glass substrate comprising a glass composition comprising xB2O3-ySiO2-zM2O, wherein 10≤x<100 by mol %; wherein 0
C03C 4/16 - Compositions for glass with special properties for dielectric glass
C03C 10/00 - Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
C04B 37/04 - Joining burned ceramic articles with other burned ceramic articles or other articles by heating with articles made from glass
An emotion analysis and recognition system including an automated recognition of bodily expression of emotion (ARBEE) system is described. The system may include program instructions executable by a processor to: receive a plurality of body movement models, each body movement model generated based on a crowdsourced body language dataset, calculate at least one evaluation metric for each body movement model, select a highest ranked body movement model based on the at least one metric calculated for each body movement model, combine the highest ranked body movement model with at least one other body movement model of the plurality of body movement models, calculate at least one evaluation metric for each combination of body movement models, and determine a highest ranked combination of body movement models to predict a bodily expression of emotion.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
42.
EXTRUSION AND CHARACTERIZATION OF COMPOUNDED RECYCLED POLYETHYLENE TEREPHTHALATE (RPET) FILAMENTS FOR MATERIAL-EXTRUSION ADDITIVE MANUFACTURING
An extrudable filament comprising recycled polyethylene terephthalate (rPET) with low-cost additives, such as at least one chain extender, toughening agent, reactive impact modifier, non-reactive impact modifier, and/or graphite powder is disclosed. Compounding rPET with such additives results in a filament that can be used in MEX-AM technologies and that displays advantageous thermal and mechanical properties. Methods of making the extrudable filament and apparatuses for making the extrudable filament are further disclosed.
C08L 67/02 - Polyesters derived from dicarboxylic acids and dihydroxy compounds
C08L 51/00 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
43.
APPARATUS UTILIZING SHAPE-MEMORY AND SELF-ASSEMBLY TO PLUG RELATIVELY WIDE REMOTE FRACTURES
Embodiments relate to a lost circulation material comprising a plurality of shape memory polymer members, each member having a temporary shape and a permanent shape. The members may be programmed to form a temporary shape that is small enough to be used with conventional drilling equipment and may further transform to corresponding permanent shapes to plug fractures. Specifically, the shape memory polymer-based lost circulation material can utilize self-assembly to plug fractures formed during drilling. Embodiments of the lost circulation material can be particularly useful for plugging large fractures. Permanent shapes present different topologies including granular, fibers, and two-dimensional networks/lattices in which can mechanically interlock and form a three-dimensional plug large enough to seal large width fractures.
C09K 8/42 - Compositions for cementing, e.g. for cementing casings into boreholesCompositions for plugging, e.g. for killing wells
E21B 21/00 - Methods or apparatus for flushing boreholes, e.g. by use of exhaust air from motor
E21B 33/138 - Plastering the borehole wallInjecting into the formation
F03G 7/06 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for using expansion or contraction of bodies due to heating, cooling, moistening, drying, or the like
44.
Integrated Circuit Design for Digital Computing and Information Processing of Mechanical Signals
A digital information processing device includes a soft material including a plurality of electrically conductive and electrically non-conductive regions. The soft material has a shape configuration configured to transform from an uncompressed configuration to fully compact configurations under an applied load. The electrically conductive regions form electrical networks that are in a closed or open state dependent upon the applied load acting on the soft material.
H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits
45.
PASSIVE BLADE-VORTEX INTERACTION NOISE REDUCTION STRATEGY USING IN-BLADE RESONATOR CAVITIES
Embodiments relate to a rotorcraft blade including a body having a top surface, a length, a width, and a thickness, wherein the body of the rotor blade comprises a plurality of resonator cavities positioned in the top surface to extend from the top surface to within the thickness of the body. Each of the resonator cavities are sized and configured to extend from the top surface to within the body for reducing a noise caused via rotation of the at least one rotor blade.
An apparatus including at least one vanadium oxide-doped laser-induced graphene sensor is disclosed. The sensor is configured to simultaneously monitor and decouple NOX gas emission and soil temperature. The apparatus may be an electronic device including a plurality of electrical components, such as a controller unit that is connected to non-transitory memory or other type of non-transitory computer readable medium and a transceiver unit.
Embodiments relate to the field of hexagonal boron nitride (hBN). In particular, to an alkali metal (A) intercalated hBN material. The A-intercalated hBN is chemically active, electrically conducting, and superconducting. The A-intercalated hBN is spontaneously soluble in aprotic organic solvents to form dispersions of exfoliated reduced 2-dimensional hBN sheets in organic solvents. The dispersions of exfoliated reduced 2-dimensional hBN materials in organic solvents materials can be reacted with metal salts to form 2-dimensional hBN-supported metal and/or metal oxide nanoparticle composites. The solutions/dispersions of exfoliated reduced 2-dimensional hBN materials in organic solvents can be transferred to water or organic solvents to form stable aqueous and organic suspensions of 2-dimensional hBN.
A switchable ferroelectric|non-ferroelectric composite (SFC) can include at least one ferroelectric layer having at least one interface with at least one non-ferroelectric layer to provide switching in the at least one non-ferroelectric layer. Embodiments can be utilized in different devices that include a capacitor, electrical equipment, a color conversion processing device, a quantum computing converter, a quasi-phase matching structure, a phase matching device, a waveguide, a resonator, a filter, a transistor, a high electron mobility transistor, a switch, a memory device having one or more capacitors, a power diode, or a power semiconducting device.
G02F 1/05 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect with ferro-electric properties
G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics
49.
METHODS AND SYSTEMS FOR ULTRASOUND STIMULATED STRUCTURES AND DELIVERY OF THERAPEUTIC SPECIES
An exemplary embodiment of the present disclosure provides compositions and methods of using compositions. A composition described herein comprises a hydrogel, a therapeutic species, and a linker joining the hydrogel to the therapeutic species. The linker joining the hydrogel to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Some aspects of this disclosure relate to methods of delivering a therapeutic species to a subject. The method comprises disposing the composition in the subject and initiating a retro Diels-Alder reaction to decompose the Diels-Alder cyclo-addition product, thereby severing the linker and decoupling the therapeutic species from the hydrogel.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Methods and processes for activity tracking and health analytics applications can include a smart ring device comprising embedded sensors configured to collect user data. The collected data can be used to provide three-dimensional finger motion tracking analysis. In addition, or alternatively, the collected data can be used to provide blood alcohol concentration measurement and analysis.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
51.
SYNTHESIS OF BIO-BASED CATECHOLIC ACID- AND DERIVATIVES-FUNCTIONALIZED ADSORBENTS FOR RECOVERY OF METALS AND METALLOIDS FROM ACIDIC SOLUTIONS
Disclosed is an adsorbent including a support and a catecholic ligand derivative. The support can be a gel, a polymeric resin, a cellulose, and/or a carbon-based material. The catecholic ligand derivative can be one of a catecholic ligand. The catecholic ligand can be 3,4 dihydroxybenzoic acid, 3,4,5-trihydroxybenzoic acid, and/or 3,4-dihydroxyhydrocinnamic acid. The catecholic ligand derivative can include a carbonyl group for covalent bonding with the support, and an O-dihydroxyl group to provide an active adsorption site.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
52.
METHOD FOR THE PRODUCTION OF HIGH PURITY BIOGASES FROM A LIGNOCELLULOSIC FEEDSTOCK
Disclosed are methods to produce a high purity biogas from a lignocellulosic biomass. The methods can include inoculating a feedstock mixture comprising the lignocellulosic biomass with a mixed microbial community; contacting the feedstock mixture with effective amount of a soluble pH adjusting agent to increase a pH of the feedstock mixture to an alkaline pH; incubating the feedstock mixture anaerobically at a thermophilic temperature of at least 45° C.; collecting the high purity biogas. In other embodiments, the method comprises inoculating a feedstock mixture comprising the lignocellulosic biomass with a mixed microbial community; anaerobically digesting the feedstock mixture at a pH, temperature, and retention time effective to afford at least 30% carbohydrate conversion of the lignocellulosic biomass to produce high purity biogas having at least 85% methane by volume. The methods disclosed herein produces substantially pure biogas and high carbohydrate conversion without the addition of non-digestible solids.
Embodiments relate to an apparatus including a capacitive iontronic pressure sensor and methods of making and using thereof. The sensor comprises a top electrode layer including a first electrode attached to a substrate, a bottom electrode layer including a second electrode having a plurality of pyramidal microstructures, and a dielectric layer including an ionic gel and positioned between the first electrode and the second electrode. The plurality of pyramidal microstructures forms a gradient array on the second electrode.
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
H01B 5/14 - Non-insulated conductors or conductive bodies characterised by their form comprising conductive layers or films on insulating-supports
54.
LOW-TEMPERATURE LIQUID-PHASE SYNTHESIS OF LITHIUM THIOPHOSPHATE-BOROHYDRIDE SOLID ELECTROLYTE WITH HIGH ROOM-TEMPERATURE IONIC CONDUCTIVITY
Embodiments relate to a scalable liquid-phase synthesis technique of lithium thiophosphate-borohydride solid electrolytes with high ionic conductivity at room temperature and its use in all-solid-state lithium batteries. A battery comprises an anode, a cathode, and a solid electrolyte layer positioned between the anode and the cathode. The liquid-phase synthesized solid electrolyte material can be used as the solid electrolyte layer or incorporated into anodes or cathodes.
H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
The present invention provides methods for obtaining plants that exhibit useful traits by suppressing MSH1 and DRM2 gene expression in plant rootstocks and grafting the rootstocks to scions. Methods for identifying genetic loci that provide for useful traits in plants and plants produced with those loci are also provided. In addition, plants that exhibit the useful traits, parts of the plants including seeds, and products of the plants are provided as well as methods of using the plants. Recombinant DNA vectors and transgenic plants comprising those vectors that provide for MSH1 and DRM2 gene suppression are also provided.
The United States of America, as represented by the Secretary, Department of Health and Human Serv (USA)
Inventor
Schneider, Joel P.
Medina, Scott H.
Abstract
The present invention is directed to peptisomes, including nanopeptisomes, which have a perfluorocarbon liquid core containing a perfluorocarbon liquid and a cargo, such as a therapeutically active agent, dispersed in the perfluorocarbon liquid, and a plurality of amphiphilic peptide molecules surrounding the perfluorocarbon liquid core, wherein the amphiphilic peptide is represented by Formula (I) HB-CL-HP wherein HB is a fluorinated hydrophobic block, such as a fluorinated hydrophobic amino acid sequence, CL is a cross-linking motif, and HP is a hydrophilic amino acid sequence. The present invention is also directed to methods of use of the amphiphilic peptides and peptisomes, such as nanopeptisomes, to deliver a cargo, such as a therapeutically active agent, to a cell, wherein the cell may be in vitro, ex vivo, or in vivo.
Embodiments relate to organic and aqueous dispersions of exfoliated bundles and individualized carbon nanothreads, and a method for making the dispersions. Embodiments involve reducing carbon nanothread crystals by an alkali metal or a mixture of alkali metals to form a carbon nanothread alkali metal compound. The carbon nanothread alkali metal compounds can be spontaneously soluble in polar aprotic organic solvents to form stable carbon nanothread dispersions. The dispersions and methods of making the same can be used for preparing carbon nanothread films for electronic devices, electrocatalytic electrodes, sensing devices and carbon nanothread/polymer nanocomposites.
Embodiments can relate to a method for defect engineering boron nitride (BN). The method can involve forming reactive BN (RBN) by breaking B—N bonds, and activation of the RBN. Forming RBN can involve cryo-milling, ball-milling, sonication, focused ion/electron beam irradiation, detonation, chemical treatment, and/or thermal treatment in limited oxygen. Activation of the RBN can involve chemical activation and/or electrochemical activation. The defect engineered BN can be used to form or be a component of an anode electrode. The anode electrode can include an electrically conductive member including a microstructure layer. The microstructure layer can be made of BN having a surface defect configured to provide a diffusion independent pseudocapacitive ion storage mechanism.
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron
H01G 11/50 - Electrodes characterised by their material specially adapted for lithium-ion capacitors, e.g. for lithium-doping or for intercalation
H01M 4/02 - Electrodes composed of, or comprising, active material
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
H01M 50/383 - Flame arresting or ignition-preventing means
59.
ELECTROMAGNETIC DEVICES AND METHODS FOR COMPLIANT ADJUSTMENT OF ELECTROMAGNETIC DEVICES
An electromagnetic device can include a compliant mechanism that can be actuated to move an element or multiple elements of the electromagnetic device between different positions, in-turn altering an electromagnetic or electric property of the device. At least one actuator can be utilized for adjustment of the body into the different positions. Examples of an actuator can include a servomotor, piston, or other type of linear motion actuator. Other types of actuators can include a motor connected to at least one gear or other type of rotatable mechanism that can be connectable to the compliant mechanism to drive movement of the compliant mechanism. Also, processes for adjusting a configuration of the electromagnetic device to adjust functionality of the device can utilize at least one compliant mechanism. Some embodiments can facilitate robust reconfiguration of an electromagnetic device with the ability to design the constituent components to not disrupt electromagnetics.
Embodiments can relate to an adsorbent including a substrate and a coating formed on a surface of the substrate. The coating can include a bifunctional hairy cellulose nanocrystal (BHCNC) having a dialdehyde group and a dicarboxylate group. Additional embodiments can relate to methods of making and using the same.
Systems and methods are disclosed that implement a near-real-time approach for characterizing Internet Background Radiation to detect and characterize network scanner activity. Various implementations can use deep representation learning to address the high dimensionality of the scanning data. In one experiment, the combination of DNN-based Autoencoder algorithms and K-means clustering was used to detect scanner activity. The insights that can be gained from clustering Darknet data can be used in instances of high-intensity scanners, malware classes that are either newly emerging or long-standing, and other situations.
In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a core-shell-shell metal nanoparticle.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
The present invention relates to a thin-film composite (TFC) membrane composition comprising macrocycles. The invention also relates in part to a method of fabricating a TFC membrane and to a method of using the TFC membrane to separate a desired liquid or gas from a liquid or gas mixture.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
Embodiments relate to a laparoscopic apparatus having a first component and a second component. The first component has a first component manipulation end configured for manipulation by a user and/or a machine, a first component interface end, a first component magnet located at or near the first component interface end, and a first component actuator system including a cable. The first component actuator system is configured to transfer control movements from the first component manipulation end into moments and forces acting upon the cable. The second component has a second component working end configured for performing surgical work, a second component interface end, a second component magnet located at or near the second component interface end, and a second component actuator system configured to transfer moments and forces acting upon the cable into mechanical movements acting upon the second component working end.
This document provides methods and materials involved in treating mammals having had a hemorrhagic stroke. For example, methods and materials for administering a composition containing exogenous nucleic acid encoding a NeuroD1 polypeptide and exogenous nucleic acid encoding a Dlx2 polypeptide to a mammal having had a hemorrhagic stroke are provided.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61P 25/00 - Drugs for disorders of the nervous system
66.
HIGH POWER SUPER-HETEROJUNCTION HIGH ELECTRON MOBILITY TRANSISTOR AND METHOD OF FORMATION
Embodiments relate to a super-heterojunction high electron mobility transistor structure. A n-type modulation doping with barrier layer induces a two-dimensional electron gas (2DEG) channel and allows for charge balancing to reduce peak electric fields at a drain-side of a gate contact to increase breakdown voltage. The n-type modulation doped layer is adjacent to at least one p-type layer to generate a charge balanced super-heterojunction region. A p-ohmic contact ensures that the processes of depleting and accumulating of electrons and holes in the structure are fast enough for practical switching operation. The structure can be expanded to a plurality of 2DEG channels. The gate and p-ohmic contact design (with utilization of spin-on-glass or other protective layer) may provide for larger breakdown voltage and mitigation of current collapse effect into the kilovolt range and beyond.
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
The subject matter of the present disclosure generally relates to techniques for isolating bacterial cells from a biological sample comprising red blood cells. Using an aggregating agent and an anticoagulant during sedimentation permits separation of bacterial pathogens in the sample from red blood cells. The separated sedimentation layer, which is enriched in any bacterial pathogens, can be centrifuged and resuspended to concentrate the bacteria for additional analysis, such as bacterial identification and/or antibiotic susceptibility tests.
Provided are compositions and methods for introducing proteins into cells. The compositions and methods relate to introducing a foreign protein as an engineered component of a paramyxovirus virus like particle (VLP). The compositions and methods pertain to modified VLPs that contain a contiguous recombinant polypeptide comprising i) all or a segment of a C-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein that is an enzyme such as a recombinase. The VLPs include at least one altered M protein, which increased yield of the VLPs by cells that produce the VLPs.
University of Florida Research Foundation, Incorporated (USA)
Arizona Board of Regents on behalf of Arizona State University (USA)
The Penn State Research Foundation (USA)
Inventor
Munger, Steven Dunn
Hayes, John E.
Gerkin, Richard C.
Abstract
An olfactory test comprising an olfactory test article including a plurality of trials that each has an associated concentration of a stimulus of interest. Aspects of the present disclosure further relate to software application that guides a user through conducting the olfactory test based at least in part on the user's responses to trials of the olfactory test article, such that the user can be guided through a custom order of trials, and therefore different concentrations of the stimuli of interest, based at least in part on the user's responses to the trials as the user performs the olfactory test.
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
70.
LIGHT SOURCES THAT INCREASE OBJECT CHROMA WHEN DIMMED
A method of increasing the color gamut of a multi-emitter light emitting device when dimming includes the steps of independently driving each emitter in the device, and increasing the lumen output of at least one emitter while simultaneously decreasing the lumen output of at least one other emitter, such that total color gamut increases while total lumen output of the light emitting device decreases. A light emitting device is also disclosed.
H01L 25/16 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices the devices being of types provided for in two or more different subclasses of , , , , or , e.g. forming hybrid circuits
H05B 45/10 - Controlling the intensity of the light
Hemorrhage and vascular instability can be induced by thrombolytic and anti-coagulant therapies. Presented herein, in certain aspects, are methods for the treatment and/or prevention of hemorrhage and vascular instability that comprise administering a compound disclosed herein to a subject in need thereof.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
72.
A PROTEIN-BASED SENSOR FOR METALS IN ENVIRONMENTAL SAMPLES AND USES THEREOF
The present disclosure provides proteins that bind lanthanides and actinides. Disclosed are proteins based on lanmodulin (LanM) that comprised one or more sensitizers. Various residues in LanM may be substituted with a sensitizer, such as, for example, tryptophan. The proteins may be used to detect and quantify lanthanides and actinides. Also provided are kits and devices.
Disclosed herein are compositions and methods for increasing the expression of human SLC7A11. The compositions include a combination of compounds that exhibit anti-proliferative activity against cancer cells. The compositions and methods can be used to treat a subject with cancer. Disclosed are also compositions and methods of treating a coronavirus infection, Zika virus, influenza virus infection, human immunodeficiency virus (HIV), or Rhinovirus.
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
A61K 31/132 - Amines, e.g. amantadine having two or more amino groups, e.g. spermidine, putrescine
A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
Embodiments relate to a magnet apparatus having a winding and a magnet management unit with a sensing module configured to measure strain and/or temperature experienced by the winding. The magnet management unit includes a processor and memory having instructions stored thereon that when executed will cause the processor to detect a change in strain and/or temperature experienced by the winding. The instructions will cause the processor to calculate a reduction of transport current that, if applied to the winding, will prevent material degradation of the winding due to strain and/or heat, and eliminate or drastically reduce down-time of the magnet apparatus. The instructions will cause the processor to generate a signal indicative of the calculated reduction of transport current, the signal configured to be transmitted to a current power supply.
H01F 27/40 - Structural association with built-in electric component, e.g. fuse
G01K 11/32 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres
75.
INTERMOLECULAR CYCLOPROPANATION OF UNSATURATED HYDROCARBONS
Disclosed are methods for forming a cyclopropyl or cyclopropenyl ring in a compound by, for example, contacting an unsaturated hydrocarbon and an active methylene compound with an oxidant and a catalytically effective amount of a photocatalyst; and irradiating the photocatalyst with a light source to form a cyclopropyl or cyclopropenyl-containing product. Also described herein are methods for forming a cyclopropyl or cyclopropenyl ring in a compound by contacting an unsaturated hydrocarbon and an active methylene compound with an oxidant under conditions effective to form a cyclopropyl or cyclopropenyl ring. Additionally disclosed herein are compounds comprising a cyclopropyl or cyclopropenyl ring formed by the methods disclosed herewith.
C07C 2/86 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation between a hydrocarbon and a non-hydrocarbon
A method and apparatus for removal of at least one rare earth element (REE) or at least one pre-selected ion can include forming a hairy nanocellulose (HNC) from a feed, feeding the HNC to a solution including the at least one REE or pre-selected ion to form solid precipitates comprising the at least one REE or pre-selected ion within the solution, and separating the solid precipitates comprising the at least one REE or pre-selected ion from a fluid of the solution.
Methods and materials are provided for the preferential separation of rare earth elements (REEs) from non-REEs in REE-containing materials and separation of certain REEs from other REEs, both individually and in groups. Such methods include steps of (a) providing a protein that can selectively bind one or more REEs; (b) contacting the protein with the REE-containing material, wherein the protein binds at least a portion of the one or more REEs to form one or more protein-REE complexes and an REE-depleted material; (c) separating the one or more protein-REE complexes from at least a portion of the REE-depleted material; and (d) separating the one or more REEs from the protein to produce a purified fraction of the one or more REEs and a regenerated protein.
B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY (Israel)
Inventor
Ruud, Christian
Giebink, Noel, C.
Gordon, Jeffrey
Abstract
An exemplary' embodiment of the present disclosure provides a device for concentrating light and methods of making and using such device. The device comprising a substantially cone-shaped optical body comprising a first side and an opposing second side extending along a central axis, the second side larger than the first side, a receiver positioned near the first side of the optical body and oriented towards the second side, and a reflector proximate the second side of the optical body, wherein a cross section of the reflector about the central axis comprises at least two substantially parabolic curves extending along a length of the second side of the optical body and converging at the central axis.
F24S 23/71 - Arrangements for concentrating solar rays for solar heat collectors with reflectors with parabolic reflective surfaces
H02S 40/22 - Light-reflecting or light-concentrating means
F24S 23/75 - Arrangements for concentrating solar rays for solar heat collectors with reflectors with conical reflective surfaces
F24S 23/79 - Arrangements for concentrating solar rays for solar heat collectors with reflectors with spaced and opposed interacting reflective surfaces
G02B 7/183 - Mountings, adjusting means, or light-tight connections, for optical elements for prismsMountings, adjusting means, or light-tight connections, for optical elements for mirrors for mirrors specially adapted for very large mirrors, e.g. for astronomy
H01L 31/054 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means
Thermosetting formulations useful for forming bulk structures such as in additive manufacturing can include (a) a compound including reactive functional groups, (b) a curing agent having functional groups reactive with the reactive functional groups of the compound, and (c) a photothermally active material. Such formulations can be cured by applying actinic radiation to the formulation.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29K 83/00 - Use of polymers having silicon, with or without sulfur, nitrogen, oxygen or carbon only, in the main chain, as moulding material
The invention includes methods of forming electronic circuitry on a target surface using intense pulsed light-induced mass transfer (IPLMT) of metal nanoparticles (NPs) by applying a pliable mask to a target surface, coating a carrier film with metal NPs, mounting the carrier film to the target surface and over the pliable mask so that the pliable mask is sandwiched between the target surface and the metal NPs. and exposing the metal NPs to light energy to cause atoms of the metal NPs to evaporate and transport through openings of the pliable mask and condense on the target surface, producing a conductive pattern of condensed metal on the target surface. Certain implementations may utilize a kirigami-patterned pliable mask to enhance conformity to a freeform 3D target surface. In certain implementations, zinc (Zn) may be formed by IPLMT of Zn NPs to the target surface.
H05K 3/14 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using spraying techniques to apply the conductive material
A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
H05K 1/09 - Use of materials for the metallic pattern
81.
ELECTRO-MECHANICAL POLYMERS AND DEVICES CONTAINING THE SAME
Disclosed herein are electro-mechanical polymer compositions comprising a ferroelectric polymer chain having a plurality of functional halogen monomer units. At least one of the plurality of functional halogen monomer units can comprise a fluorinated alkyne monomer unit. The electro-mechanical polymer compositions can have an electromechanical coupling factor of about 88% or greater and a piezoelectric coefficient of −1000 pm/V or less. Also disclosed herein are methods of making the same.
The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.
LYSOSOMAL AND RARE DISORDERS RESEARCH AND TREATMENT CENTER, INC. (USA)
THE PENN STATE RESEARCH FOUNDATION (USA)
Inventor
Goker-Alpan, Ozlem
Ozbolat, Ibrahim Tarik
Banerjee, Dishary
Abstract
This relates to an in vitro model of multicellular interactions in genetically inherited disease states, such as Gaucher disease, for studying bone cells in an engineered three¬ dimensional bone model tissue culture. The model tissue culture was produced by co-culturing in vitro: a cell from a subject (e.g., a human patient) afflicted with a disease, such as Gaucher disease, that is an osteoclast precursor; and a cell that is an osteoblast precursor; to form spheroids comprising both types of cells. The spheroids may optionally be three-dimensionally (3D) printed to form structures. These spheroids of an osteoblast precursor and an osteoclast precursor, or structures made therefrom, may be allowed to differentiate into osteoblasts and osteoclasts, thereby producing spheroids of osteoblasts and osteoclasts, or structures that are a three-dimensional bone model tissue culture comprising osteoblasts and osteoclasts. These spheroids and structures may be used to assess a proposed treatment for a disease characterized by bone defects, such as Gaucher disease, or another disorder of bone metabolism.
Embodiments relate to a flow loop system for estimating wellbore circulation density. The flow loop system includes an eccentric annulus structure having an inner eccentric pipe and an outer pipe. The inner eccentric pipe can be representative of a drill string in a wellbore. The outer pipe can be representative of the wellbore. The flow loop system includes a pressure sensor configured to measure pressure loss gradients of annular flows between the inner eccentric pipe and the outer pipe. The flow loop system includes a wellbore circulation density processing module configured to estimate the wellbore's bottomhole pressure based on the measured loss gradients of annular flows of fluid and solid particles, rotation of the inner eccentric pipe, and eccentricity of the inner eccentric pipe.
A methodology is for deriving a guidance route to any selected site including an unplanned ROI site observed in a radiologic imaging view or endoscopic video view on an assisted- endoscopy system during a live surgical endoscopic procedure based on a preloaded initial procedure plan. The initial procedure plan can be updated by identifying a new site s at the unplanned ROI on one of graphical visualization tools of an image-guided endoscope system as a new examination destination and automatically computing the new navigation airway route that leads to the new examination destination.
A technique to fabricate extraordinarily thick (e.g., greater than 1 mm, up to 2.2 mm, etc.) chiral photonic crystals (CPCs) with period number N (N = thickness/pitch) exceeding several thousands. The technique can employ two different-frequency electric fields on a standard cholesteric liquid crystal (CLC) mixture with a nematic liquid crystal constituent that possesses negative dielectric anisotropy. Starting with the CLC mixture, a direct current (DC) or a very low frequency electric field can be used to completely randomize the cholesteric helices. This can be followed by a high-frequency alternating current (AC) electric field which can exert a reorienting torque on the nematic constituent to reorder these random helices into uniform standing helices (USH)– which can provide characteristics of a well-aligned CLC that can function as a 1-D chiral photonic crystal.
Provided are compositions and methods for prophylaxis or therapy of cancer. The compositions and methods include use of Birnaviridae double stranded RNS (dsRNA) viruses for treating cancer in individuals that are not the normal virus hosts. Modifications of the dsRNA viruses are provided and include genetic changes that result improvements in anti-cancer therapy by increasing onxotoxicity of the modified viruses, and by including sequences encoding therapeutic pay loads.
Provided are proteins that bind rare earth metals. The proteins may have enhanced REE/REE selectivity. The proteins may have four EF hand motifs each having 11, 12, or 13 amino acids residues. Each EF hand motif is separated by 12 or 13 amino acid residues, where each amino acid residue is any canonical amino acid residue and at least one amino acid residue is a hydrophobic amino acid residue. When the EF hand motif has 12 amino acid residues, the motif may have the following sequence: X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-E. Also provided are devices and kits comprising a protein of the present disclosure. Also provided are methods of using the proteins and devices.
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
C01F 17/10 - Preparation or treatment, e.g. separation or purification
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
89.
ALL-NATURAL HIGH-PERFORMANCE TRIBOELECTRIC FIBERS FOR RESPIRATORS
Provided are compositions and methods that relate to materials that contain a protein component and a polysaccharide component. The proteins include alternating repeats of crystallite-forming subsequences and amorphous subsequences. The composition are capable of forming a fiber or coating, and exhibiting a triboelectric charge, and can be used in a variety of devices.
Methods, micro-Doppler radar (MDR) systems, and non-transitory computer readable media for evaluating human movement using MDR are disclosed. In some examples, a received radar signal reflected from a human subject in motion is captured via a reception antenna following output via a transmission antenna of a first transmitted radar signal toward the human subject in motion. The first transmitted radar signal is filtered from the received radar signal to yield an analog MDR signal that reflects modulation caused by movement of the human subject. A trained machine learning model is applied to digital micro-Doppler signal (MDS) data converted from the analog MDR signal to generate a result indicative of a likelihood that the human subject is at risk for an injury or other pathological condition. An indication of the result is output for display on a display device to facilitate prediction of the injury or other pathological condition.
G01S 13/53 - Discriminating between fixed and moving objects or between objects moving at different speeds using transmissions of interrupted pulse modulated waves based upon the phase or frequency shift resulting from movement of objects, with reference to the transmitted signals, e.g. coherent MTi performing filtering on a single spectral line and associated with one or more range gates with a phase detector or a frequency mixer to extract the Doppler information, e.g. pulse Doppler radar
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G08B 21/04 - Alarms for ensuring the safety of persons responsive to non-activity, e.g. of elderly persons
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Embodiments relate to a deployable and/or reconfigurable waveguide and waveguide-based components that can be configured to various states of length along a longitudinal axis such that the waveguide is an expandable structure. The waveguide can be expanded or unfolded to an expanded (or deployed) state, and the waveguide can be compressed or folded to a compressed state. The deployable waveguide comprises a hollow tube extending in a longitudinal direction. The hollow tube may be folded according to various different origami-inspired folding patterns.
The present invention relates in part to an embedded sensor for measuring the electrical resistivity or conductivity of pore solution in concrete materials and structures, wherein the sensor comprises a synthetic nanoporous ceramic, or nanoporous polymer, or cementitious material with controlled pore size. The present invention also relates to a method of measuring the electrical resistivity of pore solution in a concrete sample or a concrete structure.
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
Systems and methods for understanding emotions, including static and dynamically changing emotional states, from verbal and nonverbal communication, using only uncurated data are provided herein. Systems and methods for bodily expressed emotion understanding (BEEU), incorporating motor element analysis, are also provided herein. Systems and methods for context-aware emotion recognition in an uncontrolled real-world setting allowing for simultaneous processing of multiple subjects of interest within a single scene are also provided herein.
G10L 25/63 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for estimating an emotional state
G10L 25/57 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for processing of video signals
G10L 15/18 - Speech classification or search using natural language modelling
A61B 5/16 - Devices for psychotechnicsTesting reaction times
94.
A MULTIPLEX CRISPR BASED ASSAY FOR THE SIMULTANEOUS DETECTION OF CHLAMYDIA TRACHOMATIS AND NEISSERIA GONORRHOEAE
The present invention provides methods of detecting the presence or absence of nucleic acid from Chlamydia trachomatis and the presence or absence of nucleic acid from Neisseria gonorrhoeae in a sample from a subject using CRISPR nucleases and crRNAs specific for Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acid, kits for carrying out the methods and methods of treating subjects infected with Chlamydia trachomatis and/or Neisseria gonorrhoeae.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Artemisia annuaA. afra Mycobacterium tuberculosisMycobacterium tuberculosis (Mtb) strain mc2A. afra A. annuaA. annua A. afraA. afraA. afraA. afraA. afra resulted in isolation of a methoxylated flavone (compound 1), with considerable activity against Mtb strain mc26230.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/282 - Artemisia, e.g. wormwood or sagebrush
Artemisia annua and A. afra dichloromethane extracts contain bactericidal activity against Mycobacterium tuberculosis (Mtb) strain mc26230 under natural infection stress conditions: carbon source metabolism (glycerol, dextrose, and cholesterol) and hypoxia. Significant bactericidal activity against Mtb was observed regardless of carbon source. Extracts from A. afra showed the highest bactericidal activity against Mtb for tested carbon sources, and A. annua bactericidal activity was greatest against Mtb in minimal media with glycerol. A. annua and A. afra. extracts were bactericidal against Mtb under hypoxic conditions. Growth was halted and viability diminished several logs-fold under hypoxic conditions in the presence of each extract. Transcriptomic analysis revealed that A. afra exerts different effects on Mtb than artemisinin, indicative of phytochemicals in A. afra with unique modes of action. Biochemometric analysis of A. afra resulted in isolation of a methoxylated flavone (compound 1), with considerable activity against Mtb strain mc26230.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/282 - Artemisia, e.g. wormwood or sagebrush
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
In vivoex vivoex vivo methods of producing CAR-expressing neutrophils are also provided, as are uses of such modRNA constructs in the preparation of a medicament.
Described are methods for identifying or producing an aptamer to a target. The target can be conjugated to a microporous hydrogel. Described are also aptamer-target complexes including an aptamer and a target, where the target is conjugated to a porous hydrogel, and the aptamer selectively associates with the target.
Embodiments relate to a multi electrode array kit. The kit includes electrically conductive ink configured to adhere to a surface and form an electrode and an interconnect, an ink applicator configured to apply the electrically conductive ink to the surface, an insulative material applicator configured to apply an electrically insulative material to the surface, and an electrical contact configured to place the interconnect in electrical connection with a data acquisitioning system. Embodiments also relate to a method for performing electromyography. The method involves applying an electrically conductive ink to a surface of skin to form an electrode point, applying the electrically insulative material to the surface of skin, applying the electrically conductive ink to the insulative material to form an interconnect extending from an electrode point, and placing an electrical contact in electrical connection with the interconnect to facilitate electrical connection with a data acquisitioning system.
A61B 5/268 - Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
A61B 5/259 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes using conductive adhesive means, e.g. gels
A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
H05K 1/09 - Use of materials for the metallic pattern
100.
METHODS, COMPOSITIONS, AND SYSTEMS FOR TREATING DENTAL CARIES AND A PERIODONTAL DISEASE BASED ON MICROBIOME MODULATION THROUGH ORAL MICROBIOME TRANSPLANT (OMT)
Provided herein are methods, compositions, and systems for treating dental caries and a periodontal disease based on microbiome modulation through oral microbiome transplant (OMT). The original oral microbial composition was obtained from the dental plaque of healthy donors, and then modulated by growing a biofilm in vitro in a growth medium. The modulated oral microbial composition has a different microbial diversity than the original oral microbial composition. In the modulated oral microbial compositions, the abundance of some bacterial species changes, some new bacterial species are present, and some original bacterial species are no longer present. The modulated oral microbial composition is transplanted to the recipient's oral cavities through OMT to treat dental caries or a periodontal disease.
