A catheter, and preferably a urinary catheter, is disclosed, comprising an elongate shaft with a catheter insertion end and a flared connector connected to the elongated shaft opposite to the catheter insertion end. The flared connector forms a catheter connector end. Further, a gripping sleeve is fixedly connected to the flared connector, and arranged to enclose at least part of, and preferably essentially the whole, flared connector, apart from the catheter connector end. Hereby, a standard catheter can easily be customized for various use situations and users with different needs, in terms of e.g. gripping and manipulation possibilities. A method for producing such a customized catheter is also disclosed.
A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 μm and/or a profile section height difference (Rdc (1-99%)) of at least 18 μm. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.
A catheter assembly includes a catheter, preferably having a hydrophilic surface coating; and a package accommodating said catheter. The package preferably also accommodates a wetting fluid. The package includes a first and a second sheet material connected around the edges; a perforation line extending along a non-closed loop in one of said sheet materials, which defines a flap opening; a third sheet material connected by means of an adhesive over said flap opening. The third sheet material with a margin covers the entire flap opening. The adhesive is adapted to maintain a sterile closure of the package before use, and to be resealable after use. The third sheet material forms a tab not provided with adhesive and the tab provides a grip portion for peel opening of the package.
The invention relates to a method for modification of a biocompatible component. The method of the invention includes the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of the component, which part is covered by the metallic oxide, with an aqueous composition that includes oxalic acid; whereby a modified metallic oxide, is obtained. The invention also relates to a biocompatible component-including a substrate having a surface with a) a microstructure including pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on the microstructure, the primary nanostructure having depressions arranged in a wave-like formation.
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
C23C 8/00 - Solid state diffusion of only non-metal elements into metallic material surfacesChemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
C23C 22/46 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous acidic solutions with pH < 6 containing oxalates
The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
The present invention is based on that local administration of lithium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising lithium ions and a method for the manufacture thereof. A blasting powder comprising lithium ions, a method for locally increasing bone formation, and the use of lithium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
A flow control device for medical liquid is disclosed, comprising: a housing (1) having an inlet (2) and an outlet (3), and a channel (7) formed in an inner surface of the housing, said channel extending at least partly in axial direction; a rotatable member (5) rotatable in relation to the housing without being axially displaced, said rotatable member having at least two apertures (9a-9c); and a core member arranged inside said rotatable member, fixedly connected to said rotatable member. A helical flow path (8) being formed between the lateral surface of the core member and the inner surface of the rotatable member, said at least two apertures of the rotatable member being in communication with said helical flow path, and wherein each of said apertures debouches into the channel in at least one rotational position of the rotatable member. Further, a flow path is formed between the inlet and the outlet of the flow control device, the flow path comprising at least part of the helical flow path and the channel, wherein the flow is controlled by the rotational position of the rotatable member, determining which of said at least two apertures to be in communication with said channel, and thereby determining the length of the helical flow path to be comprised in said flow path between the inlet and the outlet.
A method is disclosed for providing a medical device with antibacterial activity, comprising the steps of: providing a substrate material coated with a hydrophilic polymer, said hydrophilic polymer exhibiting a low friction when wetted; providing a colloidal solution comprising chemically reduced particles of an oligodynamic metal and a hydrophilic polymer, said hydrophilic polymer being the same as in the coating of the substrate material; and dipping said substrate material in the solution. A medical device prepared accordingly is also disclosed. By means of this method, very advantageous properties of the antibacterial coating are obtained. In particular, a relatively low release rate is obtained in the wetting fluid, and a relatively high release rate is obtained in the intended use situation, e.g. when inserted into the urethra.
A flushable medical device for short term use, such as a urinary catheter, is disclosed, and also a method for producing such a medical device. The medical device comprises at least an elongate shaft made of a degradable material, the degradability being such that the material becomes essentially totally dissolved if maintained in turbulent water at room temperature for at least 6 hours, but retains its structural integrity in water for at least 5 minutes, and preferably at least 10 minutes. Hereby, the medical device can be used for the intended short term use, and then be flushed in an ordinary toilet after use. The degradable material preferably comprises at least one of monosaccharide, disaccharide, oligosaccharide and polysaccharide. In a preferred embodiment, the degradable material primarily comprises water, at least one of sugar and starch and gelatin.
A coupling device (1) for releasable connection of a medical tubing (2), such as a catheter, is disclosed. The coupling device has no coupling parts being inserted into the lumen of the medical tubing, and is consequently very advantageous for use with medical tubing with soft walls and/or small internal diameters. The coupling device comprises a hollow body member (110) having a first end for receiving an end part of the medical tubing, an opposite second end, for conveying an input or output to said medical tubing, and an intermediate part (113) between said first end and second end, said intermediate part being arranged to accommodate the end part of the medical tubing inserted through said first end and having an inwardly variable diameter. Further, the coupling device comprises a hollow compression sleeve (120) being arrangeable over the intermediate part of the hollow body member.
A flushable medical device for short term use, such as a urinary catheter, is disclosed, and also a method for producing such a medical device. The medical device comprises at least an elongate shaft made of a degradable material, the degradability being such that the material becomes essentially totally dissolved if maintained in turbulent water at room temperature for at least 6 hours, but retains its structural integrity in water for at least 5 minutes, and preferably at least 10 minutes. Hereby, the medical device can be used for the intended short term use, and then be flushed in an ordinary toilet after use.
The degradable material preferably comprises at least one of monosaccharide, disaccharide, oligosaccharide and polysaccharide. In a preferred embodiment, the degradable material primarily comprises water, at least one of sugar and starch and gelatin.
A catheter, and preferably a urinary catheter, is disclosed, comprising an elongate shaft with a catheter insertion end and a flared connector connected to the elongated shaft opposite to the catheter insertion end. The flared connector forms a catheter connector end. Further, a gripping sleeve is fixedly connected to the flared connector, and arranged to enclose at leat part of, and preferably essentially the whole, flared connector, apart from the catheter connector end. Hereby, a standard catheter can easily be customized for various use situations and users with different needs, in terms of e.g. gripping and manipulation possibilities. A method for producing such a customized catheter is also disclosed.
A catheter, and preferably a urinary catheter, is disclosed, comprising an elongate shaft (3) with a catheter insertion end and a flared connector (2) connected to the elongated shaft opposite to the catheter insertion end. The flared connector forms a catheter connector end (21). Further, a gripping sleeve (4) is fixedly connected to the flared connector, and arranged to enclose at least part of, and preferably essentially the whole, flared connector, apart from the catheter connector end. Hereby, a standard catheter can easily be customized for various use situations and users with different needs, in terms of e.g. gripping and manipulation possibilities. A method for producing such a customized catheter is also disclosed.
A catheter assembly is disclosed comprising a catheter, preferably having a hydrophilic surface coating; and a package accommodating said catheter. The package preferably also accommodates a wetting fluid. The package comprises: a first and a second sheet material connected around the edges; a perforation line extending along a non-closed loop in one of said sheet materials, said perforation line defining a flap opening; a third sheet material connected by means of an adhesive over said flap opening, wherein said third sheet material with a margin covers the entire flap opening. The adhesive is adapted to maintain a sterile closure of the package before use, and to be resealable after use. Further, the third sheet material forms a tab not provided with adhesive, said tab providing a grip portion for peel opening of the package.
A catheter assembly includes a catheter, preferably having a hydrophilic surface coating; and a package accommodating said catheter. The package preferably also accommodates a wetting fluid. The package includes a first and a second sheet material connected around the edges; a perforation line extending along a non-closed loop in one of said sheet materials, which defines a flap opening; a third sheet material connected by means of an adhesive over said flap opening. The third sheet material with a margin covers the entire flap opening. The adhesive is adapted to maintain a sterile closure of the package before use, and to be resealable after use. The third sheet material forms a tab not provided with adhesive and the tab provides a grip portion for peel opening of the package.
B65D 81/22 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids
B65D 75/30 - Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
The present invention relates to a fixture for insertion into a human bone. The fixture comprises a core from which a surface structure projects. At least one channel is provided in the surface of the surface structure and has an extension in a direction towards the top of the surface structure. The depth of the channel is smaller than the height of the surface structure.
The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.
B05D 3/10 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by other chemical means
C25C 3/00 - Electrolytic production, recovery or refining of metals by electrolysis of melts
A bone implant for implantation into bone tissue includes a metallic material having a surface that is covered by an oxide layer wherein the oxide layer has a thickness within the range of from 2 to 100 nm and includes strontium ions homogenously dispersed in the oxide layer. The oxide layer is a metal oxide layer formed from the metallic surface of the implant. The local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in the bone tissue.
A time and cost effective production method for medical devices with a hydrophilic coating is provided, which ensures adequate adhesion to the substrate, as well as good water retention and low friction properties. Specifically, the method comprises the steps of: providing a substrate;applying, in one or more steps, a coating solution comprising a hydrophilic polymer to a surface of said substrate to form a non-cross linked hydrophilic coating on said substrate; and irradiating the coated substrate, wherein said irradiation is adapted both to cross-link said hydrophilic coating and to simultaneously sterilize the medical device. Hereby, a non-cross linked hydrophilic coating is first obtained on the substrate, which coating is loosely connected to the substrate, and which is not fit for use as a catheter coating. However, after the step of irradiating the coated substrate, the hydrophilic coating becomes cross-linked, and fit for use e.g. on a urinary catheter. Further, since one and the same irradiation step is used to effect both cross-linking and sterilization, the production can be made more efficient, using fewer production steps and with a shortened production time.
There is disclosed a medical device, such as a urinary catheter, comprising a substrate material, a hydrophilic surface coating, e.g. comprising polyvinylpyrrolidone (PVP), arranged on at least a part of the surface of said substrate material, and an antibacterial layer comprising oligodynamic metal arranged between the substrate material and the hydrophilic surface coating. Further, the hydrophilic surface coating has a thickness large enough to provide a controlled release of oligodynamic metal ions through the hydrophilic surface coating, such as a thickness when dry that exceeds 3 μm. Hereby, the variation in the release of the oligodynamic metal ions is significantly reduced, enabling an improved control of the release. A corresponding method is also disclosed.
A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 μm and/or a profile section height difference (Rdc (1-99%)) of at least 18 μm. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e. water retention for the hydrophilic coating.
A medical device is disclosed, comprising a substrate and a hydrophilic surface coating arranged on said substrate. The substrate has, on its surface coated with said hydrophilic surface coating, a surface texture with an arithmetical mean deviation of the surface profile (Ra) of at least 3 μm and/or a profile section height difference (Rdc (1-99%)) of at least 18 μm. It has surprisingly been found that the increased surface roughness of the substrate provides significant improvements in e.g. water retention for the hydrophilic coating.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
There is disclosed a catheter assembly comprising a catheter and a receptacle. The receptacle has an elongate pocket, for accommodating at least an insertable end of said catheter, a urine collection bag, having a width extension wider than a greatest width of said elongate pocket, and at least two tab areas on at least one tab are arranged at the periphery of the urine collection bag on opposite sides of said bag. Further, in a storage state, said elongate pocket is folded over said urine collection bag, and lateral parts of said urine collection bag extending outside said elongate pocket are folded towards each other over said elongate pocket, said lateral parts being dimensioned to overlap each other in the folded disposition, and wherein said tab areas are arranged on said lateral parts and are attached to each other, in at least one point of attachment, to releasably maintain said catheter assembly in a folded disposition during storage.
There is disclosed a catheter assembly comprising a catheter and a receptacle. The receptacle has an elongate pocket, for accommodating at least an insertable end of said catheter, a urine collection bag, having a width extension wider than a greatest width of said elongate pocket, and at least two tab areas on at least one tab are arranged at the periphery of the urine collection bag on opposite sides of said bag. Further, in a storage state, said elongate pocket is folded over said urine collection bag, and lateral parts of said urine collection bag extending outside said elongate pocket are folded towards each other over said elongate pocket, said lateral parts being dimensioned to overlap each other in the folded disposition, and wherein said tab areas are arranged on said lateral parts and are attached to each other, in at least one point of attachment, to releasably maintain said catheter assembly in a folded disposition during storage.
A self-contained portable apparatus for administration of a drug solution is disclosed, comprising: a housing having an enclosure (11) for receiving a flexible pouch (10) containing a drug solution, the output of which is connectable to a conduit for delivering said drug solution to a recipient. A pressurization system is arranged for providing a constant and controllable gas pressure to the housing, wherein a controllable pressure is obtained for a controllable delivery of the drug solution. The pressurization system comprises: a pressure source (3) for delivering positive pressure gas; a pressure accumulation tank connected to said source and to said enclosure (11), arranged to provide a positive pressure reservoir; a one-way valve arranged between said pressure source and said pressure accumulation tank, enabling gas to flow solely in the direction from the pressure source to the pressure accumulation tank; and a mechanical pressure regulator arranged between said pressure accumulation tank and said housing. Hereby, an extremely stable and well controllable output pressure and output flow is obtainable.
A catheter assembly (110, 210) comprising a catheter (130, 230) and a receptacle (120, 220) is disclosed. The receptacle is arranged to accommodate at least part of said catheter and having at least one opening (123) for withdrawal of said catheter. Further, the receptacle is provided with an antimicrobial compound (301) at least in the vicinity of the opening and at least on the outer surface of the receptacle, said antimicrobial compound inhibiting microbes from being transferred to said catheter while being withdrawn through said at least one opening.
The present invention is based on that local administration of lithium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising lithium ions and a method for the manufacture thereof. A blasting powder comprising lithium ions, a method for locally increasing bone formation, and the use of lithium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.
The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
Exemplary embodiments relate to a dental abutment and methods of forming the same. The abutment (19) may include a head portion (27) located at an upper end of the abutment and constructed to support a prosthetic tooth replacement and soft tissue adjacent the head portion, an anti-rotation feature (25) located at a lower end of the abutment and constructed to mate with a dental implant, and a fillet (21) located at an interface between the head portion and the anti-rotation feature. The fillet may reduce a risk of fracture at the interface between the head portion and the anti-rotation feature. In some examples, the abutment may be formed at least partially of a ceramic material.
The present invention relates to a dental implant (1) for supporting a coronal component, said implant (1) comprising a fixture part (5) forming an apical bone contact part of said implant, an abutment part (3) forming a coronal component support part of said implant, and an abutment screw (4), wherein said abutment part (3) is arranged to, in an assembled state of said dental implant (1), be fixed to said fixture part (5) by said abutment screw (4), and wherein a coronal end portion (9) of said abutment screw (4) is arranged to, in said assembled state, be positioned coronally of a coronal end portion of said abutment part (3). The present invention also relates to abutment structures and methods for implanting a dental implant.
The present invention relates to an implant, an implant set, and a method of implanting an implant. The implant comprises an external fixture thread having a radius, thread making means at an apical end of the external fixture thread for making a bone thread in bone tissue during insertion of the implant. The thread making means having a radius, which radius is generally equal to the radius of a first portion of the external fixture thread. The radius of a second portion of said external fixture thread is further reduced in relation to said radius of said thread making means.
3. The wetting fluid could either be arranged in contact with the hydrophilic surface layer of the catheter in the receptacle, for preservation of the hydrophilic surface layer in a wetted state during accommodation in said receptacle and provision of a ready-to-use catheter assembly, or be arranged to keep the wetting fluid separated from the hydrophilic surface layer of the catheter during storage, but to be brought into contact with said hydrophilic surface layer upon activation before an intended use of the catheter. A similar method and wetting fluid is disclosed as well. The provision of the osmolality-increasing compound in the wetting fluid provides several advantages per se, such as a improved properties of the hydrophilic coating, a more predictable and controllable wetting process, a more expedient and cost efficient production, etc. Further, the use of this very high concentration of osmolality-increasing compound in the wetting fluid has proven remarkably efficient.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
patents
