A method and system for use in the fluorescence-guided laser coagulation of tumour blood vessels in a body cavity or hollow organ of the body, such as the bladder (22), and to such laser-coagulation guided by other optical indicators The system comprises a light source (12) for illuminating the surface (22) of a body cavity or hollow organ of the body; a light detector (16) for detecting light reflected from or fluoresced by the surface, a laser (24) for producing light for the coagulation of blood vessels of the tumour (46); and a beam controller (32) for controlling the application of the laser (24) based upon data from the light detector 16 such that laser light is applied only to area(s) (46) of the surface (22) from which fluorescence or another optical indicator has been detected and the margin(s) thereof.
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
The present invention relates to the treatment of bladder cancer. In particular, it relates to a composition comprising hexyl 5-ALA ester (HAL), or a pharmaceutically acceptable salt thereof, for use in a method of therapy for bladder cancer, wherein said method comprises instillation of said composition into the bladder of a patient, and wherein said method is not a method of photodynamic therapy.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic substances
adapted for medical use, plasters, materials for dressings;
fungicides. Surgical, medical, dental and veterinary apparatus and
instruments.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment of diseases and conditions, namely, cancer and precancerous conditions; chemico-pharmaceutical preparations, namely, preparations for the detection and treatment of cancer and precancerous conditions; diagnostic preparations for medical purposes, namely, for the detection of cancer and precancerous conditions Surgical apparatus and instruments for medical use
5.
Method of photodynamic therapy (PDT) for bladder cancer
This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2.
A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
6.
Method for preparing a liquid pharmaceutical composition and device for use in such method
The invention relates to a dissolution chamber (10) for use with a catheter for dissolving and preparing an aqueous solution of a water-soluble photosensitizing agent for installation into the bladder, e.g. for use in photodynamic diagnosis (PDD) or photodynamic therapy (PDT) of bladder cancer and to a method for preparing a liquid pharmaceutical preparation for delivery into a patient's bladder which includes the use of said dissolution chamber (10).
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
Surgical, medical, dental and veterinary apparatus and instruments, namely, surgical apparatus for medical, dental or veterinary use; surgical and medical, dental, and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and treatment of cancer; medical apparatus for use in providing a light source for electroluminescent light for treatment of cancer
A catheter device for use in the photodynamic treatment of a body cavity or hollow organ of the body, such as the bladder, the device being used in the photodynamic treatment of abnormalities, disorders or diseases of the internal surfaces of said body cavity or hollow organ.
This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In particular, the invention relates to a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a neoadjuvant therapy for bladder cancer in a bladder cancer patient who is scheduled for a cystectomy, the therapy comprises instilling said composition into the bladder of said patient and exposing the inside of said bladder to light.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
A61K 39/00 - Medicinal preparations containing antigens or antibodies
11.
Method of photodynamic therapy (PDT) for bladder cancer
This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
12.
METHOD FOR PREPARING A LIQUID PHARMACEUTICAL COMPOSITION AND DEVICE FOR USE IN SUCH METHOD
The invention relates to a dissolution chamber (10) for use with a catheter for dissolving and preparing an aqueous solution of a water-soluble photosensitizing agent for installation into the bladder, e.g. for use in photodynamic diagnosis (PDD) or photodynamic therapy (PDT) of bladder cancer and to a method for preparing a liquid pharmaceutical preparation for delivery into a patient's bladder which includes the use of said dissolution chamber (10).
This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In particular the invention relates to a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a neoadjuvant therapy for bladder cancer in a bladder cancer patient who is scheduled for a cystectomy, the therapy comprises instilling said composition into the bladder of said patient and exposing the inside of said bladder to light.
An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an LED lamp system 22 and a power source 41 for powering the LED lamp system 22; wherein the device is independently operational while located in the orifice; characterized in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the LED lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the LED lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment
of cancer and urological and genitourinary diseases and
medical conditions; veterinary preparations for the
diagnosis and treatment of cancer and urological, and
genitourinary diseases and medical conditions in mammals;
diagnostic preparations for medical purposes, diagnostic
preparations for veterinary purposes, sanitary preparations
for medical purposes; dietetic foods adapted for medical
use; fungicides. Application software; recorded computer programs; computer
programs stored in digital form; computer programs and
software; downloadable computer programs; computer programs
and software for use in surgical, medical and veterinary
apparatus and instruments; computer programs and software
for operating surgical, medical and veterinary apparatus and
instruments, computer programs and software for use in the
detection and diagnosis of diseases and medical conditions;
computer programs and software for use in the detection and
diagnosis of cancer and urological and genitourinary
diseases and medical conditions. Surgical apparatus and instruments for medical or veterinary
use; surgical, medical, and veterinary apparatus and
instruments; surgical apparatus and instruments for medical
or veterinary use; surgical, medical, and veterinary
apparatus and instruments for the detection, diagnosis, and
treatment of cancer and urological and genitourinary
diseases and medical conditions, lamps and light source
apparatus for medical or veterinary use; catheters, lamps
for use in photodynamic therapy and diagnosis, LED lamps for
use in photodynamic therapy and diagnosis. Scientific research services and technological consulting
services in the medical and veterinary field, research
services for others in the fields of medicine and medical
research or veterinary medicine and veterinary research;
industrial research services in the medical and veterinary
field.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment of cancer and urological and genitourinary diseases and medical conditions; veterinary preparations for the diagnosis and treatment of cancer and urological, and genitourinary diseases and medical conditions in mammals; diagnostic preparations for medical purposes, diagnostic preparations for veterinary purposes, sanitary preparations for medical purposes; dietetic foods adapted for medical use; fungicides Computer application software for mobile phone, portable media players, tablet computers, and handheld computers, namely, software for use in the detection and diagnosis of diseases and medical conditions; recorded computer programs on data media being software designed for the use in the detection and diagnosis of diseases and medical conditions; computer programs stored in digital form for use in the detection and diagnosis of diseases and medical conditions; downloadable computer programs for use in the detection and diagnosis of diseases and medical conditions; computer programs and software for use in surgical, medical, and veterinary apparatus and instruments for the detection and diagnosis of diseases and medical conditions; computer programs and software for operating surgical, medical, and veterinary apparatus and instruments for use in the detection and diagnosis of diseases and medical conditions; computer programs and software for use in the detection and diagnosis of diseases and medical conditions; computer programs and software for use in the detection and diagnosis of cancer and urological and genitourinary diseases and medical conditions Surgical apparatus and instruments for medical or veterinary use; surgical, medical, and veterinary apparatus and instruments for use in the detection, diagnosis, and treatment of cancer and urological and genitourinary diseases and medical conditions; lamps and light source apparatus for medical or veterinary use, namely, medical examination lamps, medical operating lamps, surgical lamps, lights for use in endoscopic and cystoscopic exams, and Light emitting diode (LED) apparatus for lighting, incorporated into medical instruments; catheters, lamps for use in photodynamic therapy and diagnosis, and LED lamps for use in photodynamic therapy and diagnosis Scientific research services and technological consulting services in the medical and veterinary field; research services for others in the fields of medicine, medical research, research services for others in the fields of veterinary medicine, and veterinary research; industrial research services in the medical and veterinary field
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment of cancer and urological and genitourinary diseases and medical conditions; veterinary preparations for the diagnosis and treatment of cancer and urological, and genitourinary diseases and medical conditions in mammals; diagnostic preparations for medical purposes, diagnostic preparations for veterinary purposes, sanitary preparations for medical purposes; dietetic foods adapted for medical use; pharmaceutical and veterinary preparations; dietetic substances adapted for medical use, plasters, materials for dressings; fungicides. Surgical apparatus and instruments for medical or veterinary use; surgical, medical, and veterinary apparatus and instruments; surgical apparatus and instruments for medical or veterinary use; surgical,medical and veterinary apparatus and instruments for the detection, diagnosis, and treatment of cancer and urological and genitourinary diseases and medical conditions, lamps and light source apparatus for medical or veterinary use; catheters, lamps for use in photodynamic therapy and diagnosis, LED lamps for use in photodynamic therapy and diagnosis; surgical, medical, dental and veterinary apparatus and instruments. Scientific research services and technological consulting services in the medical and veterinary field, research services for others in the fields of medicine and medical research or veterinary medicine and veterinary research; industrial research services in the medical and veterinary field; Scientific and technological services and research and design relating thereto; industrial analysis and research services.
A catheter device for use in the photodynamic treatment of a body cavity or hollow organ of the body, such as the bladder, the device being used in the photodynamic treatment of abnormalities, disorders or diseases of the internal surfaces of said body cavity or hollow organ.
This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In particular the invention relates to a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a neoadjuvant therapy for bladder cancer in a bladder cancer patient who is scheduled for a cystectomy, the therapy comprises instilling said composition into the bladder of said patient and exposing the inside of said bladder to light.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment
of cancer and illnesses and conditions, namely, cancer and
precancerous lesions; veterinary preparations for the
treatment of cancer and illnesses, namely, cancer and
precancerous lesions in dogs, cats, horses, cattle, goats
and sheep; sanitary preparations for medical purposes;
dietetic foods adapted for medical use; medical plasters;
materials for dressing, namely, bandages and gauze for
dressings, occlusive dressings, occlusive self-adhesive
dressing; occlusive foils for dressing wounds and medical
adhesive tapes; fungicides; adjuvants for medical purposes;
amino acids for medical purposes; amino acids for veterinary
purposes; chemical preparations for pharmaceutical purposes;
chemical preparations for medical purposes; chemical
preparations for veterinary purposes; chemico-pharmaceutical
preparations; diagnostic preparations for medical purposes;
diagnostic preparations for veterinary purposes; esters for
pharmaceutical purposes; medicines for human purposes;
medicines for veterinary purposes; salts for medical
purposes. Surgical apparatus and instruments for medical, dental, or
veterinary use; surgical and medical, dental and veterinary
apparatus and instruments, namely, lamps and light source
apparatus for the detection, diagnosis, and the treatment of
cancer and gynecological, urological, and
gastroenterological illnesses and conditions; catheters;
diaphragms for holding pharmaceutical preparation to cover
the cervix during photoactivation/illumination treatment, or
for keeping the pharmaceutical preparation already applied
to the cervix in place during photoactivation/illumination
treatment; caps for holding a pharmaceutical preparation to
cover the cervix during photoactivation/illumination
treatment, or for keeping the pharmaceutical preparation
already applied to the cervix in place during
photoactivation/illumination treatment; light source for use
in endoscopy and cystoscopy and for the treatment or
diagnosis of cancer of the urinary bladder or the urethra,
alone or in combination with a pharmaceutical preparation;
catheters for installing pharmaceutical preparations into or
draining pharmaceutical preparations from the urinary
bladder, endoscopy cameras for medical purposes; lamps for
medical purposes; urethral probes; urethral syringes;
urological apparatus and instruments. Advisory services relating to health; advisory services
relating to health care; advisory services relating to
medical apparatus and instruments; advisory services
relating to pharmaceutical products; alternative medicine
services; analyzing body composition of humans or animals
for medical or veterinary purposes; cervical cancer
screening services; bladder cancer screening services;
consultancy and information services relating to medical
products; dermatological services for treating skin
conditions; dermatology services; health center services;
health clinic services; health consultancy; health
counselling; hospital services; medical analysis for the
diagnosis and treatment of persons; medical analysis
services for cancer diagnosis and prognosis; medical
analysis services for the diagnosis of cancer; medical
analysis services relating to the treatment of persons;
medical analysis services relating to the treatment of
persons provided by a medical laboratory; medical and health
care clinic services; medical and pharmaceutical
consultation; medical and surgical diagnostic services;
medical and surgical services; medical care; medical care
and analysis services relating to patient treatment; medical
clinic services; medical consultancy; medical consultations;
medical equipment rental; medical screening; medical
services; medical testing; medical testing for diagnostic or
treatment purposes; physical examination; providing cancer
screening services; providing information in the field of
medicine.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment
of cancer and illnesses and conditions, namely, cancer and
precancerous lesions; veterinary preparations for the
treatment of cancer and illnesses, namely, cancer and
precancerous lesions in dogs, cats, horses, cattle, goats
and sheep; sanitary preparations for medical purposes;
dietetic foods adapted for medical use; medical plasters;
materials for dressing, namely, bandages and gauze for
dressings, occlusive dressings, occlusive self-adhesive
dressing; occlusive foils for dressing wounds and medical
adhesive tapes; fungicides; adjuvants for medical purposes;
amino acids for medical purposes; amino acids for veterinary
purposes; chemical preparations for pharmaceutical purposes;
chemical preparations for medical purposes; chemical
preparations for veterinary purposes; chemico-pharmaceutical
preparations; diagnostic preparations for medical purposes;
diagnostic preparations for veterinary purposes; esters for
pharmaceutical purposes; medicines for human purposes;
medicines for veterinary purposes; salts for medical
purposes. Surgical apparatus and instruments for medical, dental, or
veterinary use; surgical and medical, dental and veterinary
apparatus and instruments, namely, lamps and light source
apparatus for the detection, diagnosis, and the treatment of
cancer and gynecological, urological, and
gastroenterological illnesses and conditions; catheters;
diaphragms for holding pharmaceutical preparation to cover
the cervix during photoactivation/illumination treatment, or
for keeping the pharmaceutical preparation already applied
to the cervix in place during photoactivation/illumination
treatment; caps for holding a pharmaceutical preparation to
cover the cervix during photoactivation/illumination
treatment, or for keeping the pharmaceutical preparation
already applied to the cervix in place during
photoactivation/ilIumination treatment; apparatus providing
a light source for providing light for treatment or
diagnosis of cancer of the urinary bladder or the urethra,
alone or in combination with a pharmaceutical preparation;
catheters for installing pharmaceutical preparations into or
draining pharmaceutical preparations from the urinary
bladder; endoscopy cameras for medical purposes; lamps for
medical purposes; urethral probes; urethral syringes;
urological apparatus and instruments. Advisory services relating to health; advisory services
relating to health care; advisory services relating to
medical apparatus and instruments; advisory services
relating to pharmaceutical products; alternative medicine
services; analyzing body composition of humans or animals
for medical or veterinary purposes; cervical cancer
screening services; bladder cancer screening services;
consultancy and information services relating to medical
products; dermatological services for treating skin
conditions; dermatology services; health center services;
health clinic services; health consultancy; health
counselling; hospital services; medical analysis for the
diagnosis and treatment of persons; medical analysis
services for cancer diagnosis and prognosis; medical
analysis services for the diagnosis of cancer; medical
analysis services relating to the treatment of persons;
medical analysis services relating to the treatment of
persons provided by a medical laboratory; medical and health
care clinic services; medical and pharmaceutical
consultation; medical and surgical diagnostic services;
medical and surgical services; medical care; medical care
and analysis services relating to patient treatment; medical
clinic services; medical consultancy; medical consultations;
medical equipment rental; medical screening; medical
services; medical testing; medical testing for diagnostic or
treatment purposes; physical examination; providing cancer
screening services; providing information in the field of
medicine.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
35 - Advertising and business services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Pharmaceutical preparations for the diagnosis and treatment of cancer and illnesses and conditions, namely, cancer and precancerous lesions; veterinary preparations for the treatment of cancer and illnesses, namely, cancer and precancerous lesions in dogs, cats, horses, cattle, goats and sheep; medical plasters; materials for dressing, namely, bandages and gauze for dressings, occlusive dressings, occlusive self-adhesive dressing; occlusive foils for dressing wounds and medical adhesive tapes; fungicides; chemical preparations for medical purposes for detecting genetic predispositions, and for the diagnosis and treatment of cancer and illnesses and conditions, namely, cancer and precancerous lesions.
(2) Surgical instruments for medical, dental, or veterinary use; surgical and medical, dental and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and the treatment of cancer and gynecological, urological, and gastroenterological illnesses and conditions; catheters; diaphragms for holding pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; caps for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; medical light sources for use in treatment or diagnosis of cancer of the urinary bladder or the urethra , alone or in combination with a pharmaceutical preparation; catheters for installing pharmaceutical preparations into or draining pharmaceutical preparations from the urinary bladder; endoscopy cameras for medical purposes; lamps for medical purposes; urethral probes; urethral syringes and cystoscopes (1) Advisory services relating to pharmaceutical products; analyzing body composition of humans or animals for medical or veterinary purposes; cervical cancer screening services; bladder cancer screening services; consultancy and information services dermatological services for treating skin conditions; dermatology services; hospital services; medical analysis for the diagnosis and treatment of persons; medical analysis services for cancer diagnosis and prognosis; medical analysis services for the diagnosis of cancer; medical analysis services relating to the treatment of persons; medical analysis services relating to the treatment of persons provided by a medical laboratory; medical services relating to urology and medical clinic services relating to urology; medical and surgical diagnostic services; medical care and analysis services relating to patient treatment; medical clinic services; medical equipment rental; medical screening; medical testing; medical testing for diagnostic or treatment purposes; physical examination; providing cancer screening services; providing information in the field of medicine
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
35 - Advertising and business services
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Pharmaceutical preparations for the diagnosis and treatment of cancer and illnesses and conditions, namely, cancer and precancerous lesions; veterinary preparations for the treatment of cancer and illnesses, namely, cancer and precancerous lesions in dogs, cats, horses, cattle, goats and sheep; medical plasters; materials for dressing, namely, bandages and gauze for dressings, occlusive dressings, occlusive self-adhesive dressing; occlusive foils for dressing wounds and medical adhesive tapes; fungicides; chemical preparations for medical purposes for detecting genetic predispositions, and for the diagnosis and treatment of cancer and illnesses and conditions, namely, cancer and precancerous lesions.
(2) Surgical instruments for medical, dental, or veterinary use; surgical and medical, dental and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and the treatment of cancer and gynecological, urological, and gastroenterological illnesses and conditions; catheters; diaphragms for holding pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; caps for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; medical light sources for use in treatment or diagnosis of cancer of the urinary bladder or the urethra , alone or in combination with a pharmaceutical preparation; catheters for installing pharmaceutical preparations into or draining pharmaceutical preparations from the urinary bladder; endoscopy cameras for medical purposes; lamps for medical purposes; urethral probes; urethral syringes and cystoscopes (1) Advisory services relating to pharmaceutical products; analyzing body composition of humans or animals for medical or veterinary purposes; cervical cancer screening services; bladder cancer screening services; consultancy and information services; dermatological services for treating skin conditions; dermatology services; hospital services; medical analysis for the diagnosis and treatment of persons; medical analysis services for cancer diagnosis and prognosis; medical analysis services for the diagnosis of cancer; medical analysis services relating to the treatment of persons; medical analysis services relating to the treatment of persons provided by a medical laboratory; medical services relating to urology and medical clinic services relating to urology; medical and surgical diagnostic services; medical care and analysis services relating to patient treatment; medical clinic services; medical equipment rental; medical screening; medical testing; medical testing for diagnostic or treatment purposes; physical examination; providing cancer screening services; providing information in the field of medicine
An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing 1, 21, 31, 51, 61, 71 adapted to be fully inserted and secured in the orifice, the housing 1, 21, 31, 51, 61, 71 enclosing an LED lamp system 5, 25, 35, 45, 54, 62, 72 and a power source 41, 68, 78, for powering the LED lamp system 5, 25, 35, 45, 54, 62, 72, wherein the device is independently operational while located within the orifice.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an LED lamp system 22 and a power source 41 for powering the LED lamp system 22; wherein the device is independently operational while located in the orifice; characterised in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the LED lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the LED lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.
A photodynamic therapy lamp includes two lamp modules comprising an array of LEDs. Each of the lamp modules is movable between a first position in which an angle between the lamp modules is from 157 degrees to 180 degrees, and a second position in which the angle between the lamp modules is from 50 degrees to 70 degrees.
This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis:
X is a linking group.
C07C 229/24 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
C07C 229/22 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical preparations for the detection and treatment of cancer, gynaecological, urological and gastroenterological illnesses; pharmaceutical preparations for the detection and treatment of dermatological illnesses, namely, inflammatory conditions of the skin, acne vulgaris, acne rosacea, eczema, dermatological conditions caused by viral infections, namely, warts, skin cancer and pre-cancerous lesions, carcinomas, basal cell carcinoma, solar keratosis and cutaneous t-cell lymphoma (mycosis fungoides) and autoimmune skin conditions, namely psoriasis; pharmaceutical preparations for the diagnosis of cancer, gynaecological, urological and gastroenterological illnesses; pharmaceutical preparations for the diagnosis of dermatological illnesses, namely, inflammatory conditions of the skin, acne vulgaris, acne rosacea, eczema, dermatological conditions caused by viral infections, namely, warts, skin cancer and pre-cancerous lesions, carcinomas, basal cell carcinoma, solar keratosis and cutaneous t-cell lymphoma (mycosis fungoides) and autoimmune skin conditions, namely psoriasis; veterinary preparations for the detection and treatment of cancer, gynaecological, urological and gastroenterological illnesses in dogs, cats, horses, cattle, goats and sheep; veterinary preparations for the detection and treatment of dermatological illnesses in dogs, cats, horses, cattle, goats and sheep, namely, inflammatory conditions of the skin, acne vulgaris, acne rosacea, eczema, dermatological conditions caused by viral infections, namely, warts, skin cancer and pre-cancerous lesions, carcinomas, basal cell carcinoma, solar keratosis and cutaneous t-cell lymphoma (mycosis fungoides) and autoimmune skin conditions, namely psoriasis; pharmaceutical preparations for the diagnosis of cancer, gynaecological, urological and gastroenterological illnesses in animals; pharmaceutical preparations for the diagnosis of dermatological illnesses in animals, namely, inflammatory conditions of the skin, acne vulgaris, acne rosacea, eczema, dermatological conditions caused by viral infections, namely, warts, skin cancer and pre-cancerous lesions, carcinomas, basal cell carcinoma, solar keratosis and cutaneous t-cell lymphoma (mycosis fungoides) and autoimmune skin conditions, namely psoriasis; occlusive foils for dressing wounds and medical adhesive tapes; surgical, medical, dental and veterinary apparatus and instruments, namely lamps and light source apparatus for the detection, diagnosis and treatment of cancer, gynaecological, urological and gastroenterological illnesses; surgical, medical, dental and veterinary apparatus and instruments, namely lamps and light source apparatus for the detection, diagnosis and treatment of dermatological illnesses, namely, inflammatory conditions of the skin, acne vulgaris, acne rosacea, eczema, dermatological conditions caused by viral infections, namely, warts, skin cancer and pre-cancerous lesions, carcinomas, basal cell carcinoma, solar keratosis and cutaneous t-cell lymphoma (mycosis fungoides) and autoimmune skin conditions, namely psoriasis. (1) Scientific and technological services and research and design for others in the fields of medicine and medical research; industrial analysis and research services in the medical fields.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical and veterinary preparations for the diagnosis and treatment of cancer, preliminary stages of cancer, and viral infections in the womb; medical plasters; fungicides; surgical, medical, dental and veterinary apparatus and instruments, namely, medical sponges, catheters, diaphragms, caps for administering medical preparations, and light source for cancer treatment of the womb, alone or in combination with a pharmaceutical preparation for use in oncology or with an anti-viral preparation. (1) Research services in the fields of medicine and medical research; industrial analysis and research services in the medical field.
An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an LED lamp system 22 and a power source 41 for powering the LED lamp system 22; wherein the device is independently operational while located in the orifice; characterised in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the LED lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the LED lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.
The invention relates to a device for use in the photodynamic treatment of a body cavity or hollow organ of the body such as the bladder and to the use of such a device in the photodynamic treatment of abnormalities, disorders or diseases of the internal surfaces of said body cavity or hollow organ, such as of the bladder. The device comprises: an expandable structure for insertion within the body, wherein the expandable structure is arranged to be placed within the body cavity or hollow organ such that expansion of the structure will result in mechanical distention of the body cavity or hollow organ, and wherein the expandable structure is arranged such that light emitted within the body cavity or hollow organ when it has been distended by expansion of the expandable structure will irradiate an internal surface of said body cavity or hollow organ.
A photodynamic therapy lamp includes two lamp modules comprising an array of LEDs. Each of the lamp modules is movable between a first position in which the two lamp modules are oriented substantially parallel with each other in substantially the same plane, and a second position in which the angle between the lamp modules is from 50 degrees to 70 degrees.
The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.
C07C 229/22 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
38.
Form of hexyl-5-aminolevulinate hydrochloride and methods of using the same
This invention relates to a novel crystalline polymorph of hexyl-5-aminolevulinate hydrochloride, referred to hereinafter as Form C, which is useful as precursor of a photo sensitizer in the photodynamic diagnosis and treatment of metabolically active cells related to diseases such as cancer of the uterus, cervix, vagina, rectum, colon, lower gastrointestinal tract; infection associated with cancer caused by human papilloma virus; non-cancerous lower gastrointestinal tract a human; inflammatory bowel disease; ulcerative colitis; Crohn's disease; inflammatory bowel syndrome; dysplasia of the female reproductive system; anus; penis; rosacea; and acne and which is suitable for use as the active ingredient of a commercial pharmaceutical product. The invention relates further to methods of preparing Form C and using it in the described pharmaceutical compositions.
C07C 229/22 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
A portable, self-contained, irradiation apparatus for photodynamic treatment of the vulva and/or the anus which comprises: a treatment surface 2 capable of conforming to the area of the vulva and/or anus to be treated, an illumination system 4 for directing light onto a treatment area of the vulva and/or anus and a power source 18 for the illumination system; wherein the illumination system is arranged to provide light at fluence rates of 50 mW/cm2 or below.
This invention relates to the treatment and diagnosis of abnormalities of the epithelial-lined surface of the esophagus and, in particular, to esophageal stents having a surface coating comprising a photosensitizing agent or a precursor thereof for use in methods of photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of the esophagus. The stents find particular use in methods of diagnosing and/or treating Barrett's esophagus and in diagnostic methods for monitoring the progression of the disease.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
This invention relates to the diagnosis of abnormalities of the epithelial-lined surface of the esophagus and, in particular, to the use of esters of 5-aminolevulinic acid (5-ALA) in methods of photodynamic diagnosis (PDD) of Barrett's esophagus and in diagnostic methods which monitor the progression of the disease with high specificity.
This invention relates to dry pharmaceutical compositions comprising an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA, or a pharmaceutically acceptable salt thereof. The compositions may be used in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions. The invention relates further to irradiation devices comprising dry compositions and the use of such devices in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions.
Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer.
The present invention relates to compositions comprising a derivative of 5 - aminolevulinic acid (5-ALA), e.g. an ester of 5-ALA or a skin compatible salt thereof. Further, the invention relates to use of such compositions in methods of cosmetic or therapeutic treatment, particularly in methods of improving or otherwise enhancing the appearance of the skin. The compositions comprise 2% by weight or less of a derivative of 5-ALA, 70% by weight or more of water, 2-25% by weight of at least one liquid carrier and one or more emulsifiers. A container comprises a first compartment comprising a derivative of 5-ALA and at least one liquid carrier and a second compartment comprising water, one or more emulsifiers and optionally at least one liquid carrier. The composition is obtained by mixing the contents of the two compartments.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
11 - Environmental control apparatus
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Cosmetic products, namely, creams, gels, oils, lotions, butters, toners, masks and scrubs, all for the face, hands and body; products for rejuvenescense of the skin, namely, creams, gels, oils, lotions, butters, toners, masks and scrubs; products for regeneration of the skin, namely, creams, gels, oils, lotions, butters, toners, masks and scrubs; products for the removal of wrinkles, namely, creams, gels, oils, lotions, butters, toners, masks and scrubs; pharmaceutical preparations for the detection and treatment of cancer, gynaecological, urological and gastroenterological illnesses and dermatological illnesses; pharmaceutical preparations for the diagnosis of cancer, gynaecological, urological and gastroenterological and dermatological illnesses in animals; veterinary preparations for the detection and treatment of cancer, gynaecological, urological and gastroenterological illnesses and dermatological illnesses in dogs, cats, horses, cattle, goats and sheep; pharmaceutical preparations for the diagnosis of cancer, gynaecological, urological, gastroenterological and dermatological illnesses in animals; surgical and medical dressings; occlusive foils for dressing wounds; fungicides; surgical, medical, dental and veterinary apparatus and instruments, namely lamps and light source apparatus for the detection, diagnosis and treatment of cancer, gynaecological, urological and gastroenterological illnesses and dermatological illnesses; apparatus for lighting, namely lamps, overhead lamps, ultraviolet lamps; fluorescent lamps; lighting fixtures; light bulbs; spotlights; laser light projectors; LED lamps for use in photodynamic therapy and diagnosis and infrared lamps. (1) Scientific and technological services and research and design for others in the fields of medicine and medical research; industrial analysis and research services in the medical fields.
46.
Acid addition salts of 5-aminolevulinic acid or its derivatives
The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.
This invention relates to solid compositions and solid pharmaceutical products for use in methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions in the lower part of the gastrointestinal system. The solid pharmaceutical compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of photodynamic diagnosis of cancer, pre-cancerous and non-cancerous conditions of the lower gastrointestinal tract, wherein the solid pharmaceutical compositions and pharmaceutical products are used.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 9/02 - SuppositoriesBougiesBases for suppositories or bougies
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
48.
SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS
This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic substances
adapted for medical use, food for babies; plasters,
materials for dressings; material for stopping teeth, dental
wax; disinfectants; preparations for destroying vermin;
fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments, artificial limbs, eyes and teeth; orthopedic
articles; suture materials. Scientific and technological services and research and
design relating thereto; industrial analysis and research
services; design and development of computer hardware and
software.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical preparations for the detection and treatment of cancer and precancerous lesions, gynaecological, urological and gastroenterological illnesses ; pharmaceutical preparations for cancer diagnosis and for the diagnosis of aforementioned illnesses; veterinary preparations for the detection and treatment of cancer, gynaecological, urological and gastroenterological illnesses in dogs, cats, horses, cattle, goats and sheep; pharmaceutical preparations for cancer diagnosis and for the aforementioned illnesses in animals; surgical instruments for medical, dental, or veterinary use; surgical and medical, and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and treatment of cancer and gynaecological, urological and gastroenterological illnesses and conditions; catheters, apparatus providing a light source for electroluminescent light for diagnosis or treatment of cancer of the womb alone or in combination with a pharmaceutical preparation. (1) Scientific research services and technological consulting services in the medical field, research services for others in the fields of medicine and medical research; industrial research services in the medical field; medical research services.
An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing 1, 21, 31, 51, 61, 71 adapted to be fully inserted and secured in the orifice, the housing 1, 21, 31, 51, 61, 71 enclosing an LED lamp system 5, 25, 35, 45, 54, 62, 72 and a power source 41, 68, 78, for powering the LED lamp system 5, 25, 35, 45, 54, 62, 72, wherein the device is independently operational while located within the orifice.
This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
2), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).
A01N 37/12 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group , wherein Cn means a carbon skeleton not containing a ringThio-analogues thereof
A61N 1/30 - Apparatus for iontophoresis or cataphoresis
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations for the diagnosis and treatment of cancer and illnesses and conditions, namely, cancer and precancerous lesions [ ; veterinary preparations for the treatment of cancer and illnesses, namely, cancer and precancerous lesions in dogs, cats, horses, cattle, goats, and sheep; sanitary preparations for medical purposes; dietetic foods adapted for medical use; medical plasters; materials for dressings, namely, bandages and gauze for dressings, occlusive dressings, occlusive self-adhesive dressing; occlusive foils for dressing wounds, and medical adhesive tapes; and fungicides ] Surgical apparatus and instruments for medical [, dental, or veterinary ] use [ ; surgical and medical, dental, and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and treatment of cancer and gynecological, urological, and gastroenterological illnesses and conditions; catheters, diaphragms for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; caps for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; apparatus providing a light source for electroluminescent light for treatment of cancer of the womb, alone or in combination with a pharmaceutical preparation ] [ Scientific research services and technological consulting services in the medical field, research services for others in the fields of medicine and medical research; industrial research services in the medical field ]
55.
USE OF 5-AMINOLEVULINIC ACID AND DERIVATIVES IN A SOLID FORM FOR PHOTODYNAMIC TREATMENT AND DIAGNOSIS
The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non- cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations for the treatment of cancer [and dermatological illnesses and conditions] [ ; veterinary preparations for the treatment of cancer and dermatological illnesses in dogs, cats, horses, cattle, goats and sheep; sanitary preparations for medical purposes; dietetic foods adapted for medical use; medical plasters; materials for dressings, namely, bandages and gauze for dressings, occlusive dressings, occlusive self-adhesive dressing; occlusive foils for dressing wounds and medical adhesive tapes; and fungicides ] Surgical apparatus and instruments for medical [, dental, or veterinary ] use [ ; surgical and medical, dental, and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and treatment of cancer and gynecological, urological, gastroenterological, and dermatological illnesses and conditions; catheters, diaphragms for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; caps for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; apparatus providing a light source for electroluminescent light for treatment of cancer of the womb alone or in combination with a pharmaceutical preparation ] [ Scientific research services and technological consulting services in the medical field, research services for others in the fields of medicine and medical research; industrial research services in the medical field ]
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic substances
adapted for medical use, plasters, materials for dressings;
fungicides. Surgical, medical, dental and veterinary apparatus and
instruments. Scientific and technological services and research and
design relating thereto; industrial analysis and research
services.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations for the treatment of cancer [ and dermatological illnesses and conditions ] [ ; veterinary preparations for the treatment of cancer and dermatological illnesses in dogs, cats, horses, cattle, goats and sheep; materials for dressings, namely, bandages and gauze for dressings, occlusive dressings, occlusive self-adhesive dressing; occlusive foils for dressing wounds and medical adhesive tapes ] [ Surgical and medical [, dental, and veterinary ] apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis, and treatment of cancer and gynecological, urological, gastroenterological, and dermatological illnesses and conditions; catheters, diaphragms for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; caps for holding a pharmaceutical preparation to cover the cervix during photoactivation/illumination treatment, or for keeping the pharmaceutical preparation already applied to the cervix in place during photoactivation/illumination treatment; apparatus providing a light source for electroluminescent light for treatment of cancer of the womb alone or in combination with a pharmaceutical preparation ] [ Scientific research services and technological consulting services in the medical field, research services for others in the fields of medicine and medical research; industrial research services in the medical field ]
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical preparations for the diagnosis and treatment of cancer and precancerous illnesses; pharmaceutical preparations for use in dermatology, namely, dermatitis, acne, acne rosacea, skin infections and psoriasis; veterinary preparations for the treatment of cancer and dermatological illnesses in dogs, cats, horses, cattle, goats and sheep; materials for dressings; occlusive foils for dressing wounds and medical adhesive tapes; surgical, medical, dental and veterinary apparatus and instruments, namely, lamps and light source apparatus for the detection, diagnosis and treatment of cancer and gynecological, urological, gastroenterological and dermatological illnesses and conditions. (1) Research services in the fields of medicine and medical research, industrial analysis and research services in the medical fields.
60.
USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF
The invention provides the use of a photosensitiser which is 5- aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10 % wt (e.g. 0.5 to 8 %wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).
A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic substances
adapted for medical use, plasters, materials for dressings;
fungicides. Surgical, medical, dental and veterinary apparatus and
instruments. Scientific and technological services and research and
design relating thereto; industrial analysis and research
services.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical [ and veterinary ] preparations for the treatment of cancer, preliminary stages of cancer, and viral infections in the womb [ ; sanitary preparations for medical purposes; medical plasters; materials for dressings, namely, self-adhesive dressings; medical sponges ] Surgical, medical, [ dental, and veterinary ] apparatus and instruments, namely, [ catheters, diaphragms, ] caps for administering medical preparations, and apparatus providing a light source for cancer treatment of the womb, alone or in combination with a pharmaceutical preparation [ Scientific and technological services and research and design for others in the fields of medicine and medical research; industrial analysis and research services in the medical field ]
This invention provides a pharmaceutical product comprising a photosensitiser which is 5-ALA or a precursor or derivative thereof and a non-photosensitising therapeutic agent, for example 5-fluorouracil, mitromycin, metronidazole etc.
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic substances
adapted for medical use, plasters, materials for dressings;
fungicides. Surgical, medical, dental and veterinary apparatus and
instruments. Scientific and technological services and research and
design relating thereto; industrial analysis and research
services.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical, veterinary and hygienic preparations and substances; dietetic substances for medical use, food for babies; plasters and materials for dressings; material for stopping teeth and dental wax; disinfectants; preparations for destroying vermin and insects; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; dietetic substances
adapted for medical use, food for babies; plasters,
materials for dressings; material for stopping teeth, dental
wax; disinfectants; preparations for destroying vermin;
fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments, artificial limbs, eyes and teeth; orthopedic
articles; suture materials.
