Abstract

if the preparative route is selected in the switching step, a preparative step according to the preparative route.

IPC Classes  ?

• B01D 15/40 - Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• G01N 30/46 - Flow patterns using more than one column
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups

Abstract

The invention relates to a method for liquid or supercritical fluid chromatography of a product P. The method according to the invention comprises continuously and in order: - a step (10, 30) of analysing in an analysis channel (1); - a switching step (X1, X2) comprising an operation (402, 502) for changing channel between the analysis channel (1) and a preparation channel (2); and - in case of selection of the preparation channel (2) in the switching step, a step (20) of preparing in the preparation channel (2).

IPC Classes  ?

• G01N 30/26 - Conditioning of the fluid carrierFlow patterns
• B01D 15/40 - Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
• G01N 30/46 - Flow patterns using more than one column

Abstract

A chromatography or supercritical extraction method is disclosed, in which the eluent comprises a mixture of a fluid and a modifier and in which the fluid is recycled. One exemplary method comprises an operation consisting in determining at least one quantity linked to the level of modifier that is mixed with the recycled fluid and, if necessary, a correction operation in order to limit variations in the level of modifier in the eluent at the inlet of the column or the extractor. The disclosure also relates to a chromatography or extraction installation.

IPC Classes  ?

• B01D 15/08 - Selective adsorption, e.g. chromatography

Abstract

A method for the high-pressure delivery of a mixture comprises delivering at least first and second fluids. The method comprises operations consisting in forming a mixture of fluids in a mixing zone having a pressure that is less than the desired high pressure and bringing the pre-mixed fluids to the high pressure. The first fluid is introduced into the mixing zone by a pumping operation that is performed by a high-pressure pump that is positioned downstream of the mixing zone. A device for performing the method is described.

IPC Classes  ?

• F04B 25/00 - Multi-stage pumps specially adapted for elastic fluids
• F04B 23/08 - Combinations of two or more pumps the pumps being of different types

Abstract

A method for the superficial-phase chromatography of a product comprises the steps which are performed continuously in the following order, namely: an operation consisting in pumping a supercritical fluid; and operation consisting of injecting at least one sample of product into at least one chromatography column, a detection operation, and a fraction collection operation. The method comprises at least a first diversion along between an analytical channel and a preparatory channel, which diversion is performed prior to the supercritical fluid pumping operation and the analytical and preparatory channels each including respective supercritical fluid pumping operations. The method is also characterized in that the collection operation is common to both the analytical and preparatory channels. An installation used to implement one such method is described.

IPC Classes  ?

• G01N 30/04 - Preparation or injection of sample to be analysed
• G01N 30/72 - Mass spectrometers