The invention concerns a method to discriminate an urinary tract infection (UTI) from an urinary tract infections able to cause urosepsis using a system consisting of a light source (1) which emits radiation having a central wavelength within the range of 200-780 nm, a cuvette (2) into which an urine sample (3) is inserted or a container (2) with an urine sample (3) into which a measuring probe (6) is dipped, a detector (4), wherein the detector (4) is placed at a distance from the light source (1), and an analyser (5) programmed to classify the urine sample (3) to UTI/Urosepsis based on the reading of a differentiating factor R determined by the analyser (5).
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/85 - Investigating moving fluids or granular solids
G01N 33/493 - Physical analysis of biological material of liquid biological material urine
2.
INHIBITORS OF INTERACTIONS BETWEEN TRF1-TIN2 OR TRF2-TIN2 TELOMERIC PROTEINS FOR USE IN ANTICANCER THERAPY
INSTYTUT IMMUNOLOGII I TERAPII DOŚWIADCZALNEJ IM. LUDWIKA HIRSZFELDA POLSKIEJ AKADEMII NAUK (Poland)
INSTYTUT BIOLOGII DOŚWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK (Poland)
SZPITALE POMORSKIE W GDYNI SP. Z O.O. (Poland)
EU-CONSULT SP. Z O.O. (Poland)
INNOVABION SP. Z O.O. (Poland)
Inventor
Bagiński, Maciej
Skowron, Piotr
Żebrowska, Joanna
Prusinowski, Maciej
Węgrzyn, Katarzyna
Brankiewicz, Wioletta
Żylicz-Stachula, Agnieszka
Szajewski, Mariusz
Kalathiya, Umesh
Padariya, Monikaben
Maciejewska, Natalia
Drab, Marek
Makowiec, Sławomir
Krzemieniecki, Radosław
Abstract
The present invention relates to a novel compounds for use in treatment or prevention of cancer, in particular to use of said compounds as an inhibitors of interactions between TRF1-TIN2 or TRF2-TIN2 telomeric proteins.
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
INSTYTUT IMMUNOLOGII I TERAPII DOŚWIADCZALNEJ IM. LUDWIKA HIRSZFELDA PAN (Poland)
INSTYTUT BIOLOGII DOŚWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK (Poland)
SZPITALE POMORSKIE W GDYNI SP. Z O.O. (Poland)
EU-CONSULT SP. Z O.O. (Poland)
INNOVABION SP. Z O.O. (Poland)
Inventor
Bagiński, Maciej
Skowron, Piotr
Żebrowska, Joanna
Prusinowski, Maciej
Węgrzyn, Katarzyna
Brankiewicz, Wioletta
Żylicz-Stachula, Agnieszka
Szajewski, Mariusz
Kalathiya, Umesh
Padariya, Monikaben
Maciejewska, Natalia
Drab, Marek
Makowiec, Sławomir
Krzemieniecki, Radosław
Abstract
The present invention relates to a novel compounds for use in treatment or prevention of cancer, in particular to use of said compounds as an inhibitors of interactions between TRF1-TIN2 or TRF2-TIN2 telomeric proteins.
C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
The invention concerns a cap (1) for a dermatoscope (2) which features built-in magnets (3), where the cap (1) is composed of a magnetic screen (5) made of a magnetically soft material and at least one protective casing (6,7,8). The cap (1) is designed for application in dermatoscopes to examine patients with cardiac implantable electronic devices.
The satellite mechanism with an eight-humped or six-humped externally toothed planet, a multi-humped internally toothed curvature and satellites is characterized in that the number of satellites is equal to the sum of the number of humps of the planet and the number of humps of the bypass, while the humps of the planet have the structure of the running line LT, which is shaped around the circle OK with diameter D such that for any angle a. assumed from the range <0,360°) with a vertex in the rotation center SP of the planet and contained between any axis of the XY coordinate system with the beginning in the rotation center SP of the planet and the half-line K with the beginning in the rotation center SP of the planet exists point of intersection PP of the half-line K with the beginning in the rotation center SP of the planet with the rolling line LT, the distance R of which from the rotation center SP of the planet P has a value that satisfies the relationship given in the description.
F04C 2/14 - Rotary-piston machines or pumps of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing of other than internal-axis type with toothed rotary pistons
A hybrid multi-source storage for cooperation with the HVAC system of an electric vehicle is characterized by the fact that it has at least three tanks filled with phase- change PCM materials, preferably with different properties, where the first tank is a container (1) connected by heat pipes (6) to at least two tanks, which are thermal stores (2), each of them at the other end connected by means of coil exchangers (5), preferably of helicoidal shape or straight finned channels, with a manifold (4) supplying a condensing / evaporating medium, preferably an intermediary medium, which is a refrigerant or a non-condensable / non-evaporation medium. Each thermal store (2) has at least one heat pipe (6) and no more than one coil exchanger (5) or a straight finned channel. At least two thermal stores (2) constitute a single link of a thermal store (7). The container (1) is filled with the phase change material, which is biodegradable and has a phase transition temperature range from -78.5°C to 150°C, and the thermal stores (2) are filled with the phase change material, which is biodegradable and has a phase transition temperature range from 0°C to 130°C.
The subject matter of the invention is a device for taking intraoperative measurements of blood supply to the tissues of the organs of the gastrointestinal tract during surgical anastomosis of parts of the gastrointestinal tract, wherein the device contain a holder (5) composed of two arms crossing over at the connection point, where the first and the second ends of both arms: an upper arm (5a) and a lower arm (5b) are arranged parallel so that on the same, mutually parallel ends the lower arm (5b) is fitted with an internal sleeve (2) and an external sleeve (8), with measuring sensors (4) arranged along the outer circumference of the internal sleeve (2) and on the inner circumference of the external sleeve (8), wherein on its inner circumference the external sleeve (8) has a groove accommodating a flexible pressing conduit in the form of a torus (3) which enables the closure of the clearance between the sleeves, and the upper arm (5a) is fitted with pressing elements (6) and (9), wherein at its first ends each of the arms (5a) and (5b) has at least one measuring sensor (7), wherein the sensors (7) are located opposite each other.
A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
A61B 17/122 - Clamps or clips, e.g. for the umbilical cord
REACTOR AND METHOD FOR THE PYROLYSIS OF INDUSTRIAL OR MUNICIPAL WASTE AND FOR THE REDUCTION AND PURIFICATION OF PYROLYSIS GAS FROM HEAVY HYDROCARBONS AND CARBON PARTICLES
The invention relates to a method and a reactor for pyrolysis of industrial or municipal waste such as materials selected from the group consisting of underwood chips, wood waste, forest waste, sewage sludge, petroleum coke, municipal solid waste (MSW) or refuse derived fuels (RDF), and for the reduction and purification of pyrolysis gas from heavy hydrocarbons and carbon particles. A reactor for pyrolysis of industrial or municipal waste containing a vacuum-tight chamber is characterized by the fact that the space of the proper chamber is divided into four compartments, inside which there is a thermal insulation made of low-absorbent materials. The charge introduced through the first compartment is pyrolysed in the second compartment, and in the third compartment there is also a shelf on which a layer of carbonizate with a temperature of 850-1000° C is formed, acting as a catalyst for the reduction and purification of pyrolysis gas. The carbonizate layer with a temperature of 900-1000° C passes continuously into the carbonizate column in the fourth compartment with the temperature decreasing with the height of the column. The carbonizate column acts as an additional pyrolysis gas filtering and thermal insulation, and is cooled in its lower part with water. The heating of the charge and carbonizate, necessary for the process, is provided by electric heaters and / or a burner powered by pyrolysis gas. The reactor allows for the continuous process of feeding the charge, its pyrolysis, removal of carbonizate and obtaining purified pyrolysis gas. The invention also relates to a method for the reduction and purification of pyrolysis gas.
The invention relates to a process for the production of new polyurethane materials from polyols and wood waste and / or wood-like waste. This method is characterized by the use of polyol synthesized from wood waste and / or wood-like waste polyols or petrochemical polyols are used. A polyol mixture is prepared by mixing 1-100 parts by mass of polyols obtained from wood waste and/or 1-100 parts by mass of polyols obtained from wood-like waste and/or 1-100 parts by mass of petrochemical oligomerols and 0.01-10 parts by mass catalysts. Moreover, surfactants, anti-foaming agents, blowing agents and milled waste after wood processing or milled wood-like waste can be used. The resulting polyol mixture is then mixed with the isocyanate in an NCO / OH molar ratio ranging from 0.5 to 4.
C08L 97/02 - Lignocellulosic material, e.g. wood, straw or bagasse
C08J 5/06 - Reinforcing macromolecular compounds with loose or coherent fibrous material using pretreated fibrous materials
10.
THE METHOD OF OBTAINING REACTIVE POLYOLS FROM WOOD-BASED WASTE, THE METHOD OF MANUFACTURING POLYURETHANE MATERIALS FROM THE OBTAINED REACTIVE POLYOLS AND REACTIVE POLYOLS OBTAINED FROM WOOD-BASED MATERIALS
The invention relates to a process for the production of reactive polyols from wood-like waste materials on the fact that the wood-like waste material is used as a wood-like material, which is chipped to a grain size of 1 to 500 pm, and this material is subjected to a solvolysis process in the presence of a solvent or mixture of solvents with the amount of biomass from 1-50% of the weight of the solvent with the catalyst at the temperature from 80 to 300 ° C and the obtained polyol raw material is neutralized with an acid or a base.
C08G 18/64 - Macromolecular compounds not provided for by groups
11.
Sulfamate derivatives of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenol, derivatives of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenol, their medical use and the method of obtaining 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamate derivatives
The present invention relates to 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamate derivatives and derivatives of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenol as new compounds. The subject of the invention is the medical use of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamate derivatives and the medical use of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenol derivatives. The subject of the invention is the use of new compounds as an agent with the properties of a steroid sulfatase inhibitor and/or an estrogen receptor modulator. The present invention relates to the medical use of novel compounds for use as an antimicrobial medicament and/or estrogen receptor modulator. In particular, 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamate derivatives are for use as medicament in cancer therapy. The invention also relates to a process for the preparation of these new compounds, wherein the derivatives of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenol are the intermediate product from which the sulfamate derivatives are obtained.
The method of production of polyols from plant biomass is characterized by the use of soft and/or hardwood or bark from soft and/or hardwood with a grain size between 50 and 800 pm. They are subjected to the process of solvolysis in the presence of a solvent or a mixture of solvents with an amount of biomass ranging from 1-50% by weight of the solvent with the use of a catalyst in the form of acid or alkali and acid and alkali in the amount of 0.01 to 20% by weight to the solvent. The process is carried out at a temperature from 80 to 300 °C in 60 to 600 min and then the resulting polyol is neutralized using acid or alkali.
The invention relates to bitumen modifying agent, polymer modified bitumen, being modified by physical and chemical methods, and the methods for preparation of polymer modified bitumen. Polymer modified bitumen comprises bitumen and oil-rubber composition, obtained by mixing shredded waste rubber with castor oil, and also comprises crosslinking component with reactive isocyanate groups (NCO) in its structure. Polymer modified bitumen contains, calculated on the weight of polymer modified bitumen, bitumen in the amount from 77% wt. to 95% wt. and oil- rubber composition in the amount from 4% wt. to 20% wt., while content of particles of waste rubber is from 4% wt. to 18% wt., while castor oil is from 0,25% wt. to 3% wt. The polymer modified bitumen additionally comprises crosslinking component in the form of compound with free isocyanate groups (NCO) in the amount from 0,25% wt. to 3% wt.
C08L 95/00 - Compositions of bituminous materials, e.g. asphalt, tar or pitch
C08J 11/26 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic oxygen-containing compounds containing carboxylic acid groups, their anhydrides or esters
C08G 18/02 - Polymeric products of isocyanates or isothiocyanates of isocyanates or isothiocyanates only
C09D 195/00 - Coating compositions based on bituminous materials, e.g. asphalt, tar or pitch
B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
15.
SULFAMATE DERIVATIVES OF 4-(1-PHENYL-1H-[1,2,3]TRIAZOL-4-YL)-PHENOL, DERIVATIVES OF 4-(1-PHENYL-1H-[1,2,3]TRIAZOL-4-YL)-PHENOL, THEIR MEDICAL USE AND THE METHOD OF OBTAINING 4-(1- PHENYL-1H-[1,2,3]TRIAZOL-4-YL)-PHENYL SULFAMATE DERIVATIVES
The present invention relates to 4-(1-phenyl-1H-[1,2,31triazol-4-yl)-phenyl sulfamate derivatives as new compounds. The subject of the invention is the medical use of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamate derivatives. The subject of the invention is the use of new compounds as an agent with the properties of a steroid sulfatase inhibitor and / or an estrogen receptor modulator. The present invention relates to the medical use of novel compounds for use as estrogen receptor modulator. In particular, 4-(1-phenyl-1H-[1,2,3]triazol-4- yl)- phenyl sulfamate derivatives are for use as medicament in cancer therapy. The invention also relates to a process for the preparation of these new compounds, wherein the derivatives of 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenol are the intermediate product from which the sulfamate derivatives are obtained. In particular, sulfamate derivatives of formula 1 are provided:
METHOD FOR MANUFACTURING OF INORGANIC SALTS WITH MONOVALENT CATION AND ANION OF TRANSITION METAL ACID, IN PARTICULAR IN THE FORM OF MICRO- AND NANOCRYSTALS
xyz44 +or K+or Rb+or Cs+; M: Mo or V, O: oxygen, comprising precipitation of solids from molybdenum trioxide or vanadium pentoxide solution by potassium or rabidium or cesium or ammonium salt. According to the invention, the used salt is at least one organic salt of potassium or rabidium or cesium or ammonium. The salt is being dissolved in at least one solvent and the obtained solution is being mixed with molybdenum trioxide or vanadium pentoxide, keeping the weight ratio of potassium or rubidium or cesium or ammonium salt to molybdenum trioxide or vanadium pentoxide as at least 1:1.
The subject of the invention is a satellite hydraulic motor characterized by the fact that between the satellite working mechanism and body (5), there is a compensation plate (6) with at least one compensation hole (OK) connecting the crevice created by the face of the planet (2) and the compensation plate (6) with the compensation chamber (KK), while on the other side of the working mechanism, the rear of the motor is contacted by the commutation plate (7) with the inflow (KR1) and outflow (KR2) commutation channels and the number of these channels equals twice the number of the lobes of curvature. Manifold (8) is located behind the commutation plate (7).
F01C 1/14 - Rotary-piston machines or engines of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing of other than internal-axis type with toothed rotary pistons
F01C 19/08 - Axially-movable sealings for working fluids
F04C 2/14 - Rotary-piston machines or pumps of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing of other than internal-axis type with toothed rotary pistons
F04C 15/00 - Component parts, details or accessories of machines, pumps or pumping installations, not provided for in groups
F03C 2/08 - Rotary-piston engines of intermeshing-engagement type, i.e. with engagement of co-operating members similar to that of toothed gearing
19.
USE OF ZEBULARINE FOR PROMOTING WOUND HEALING AND REGENERATION
INSTYTUT BIOLOGII DOŚWIADCZALNEJ IM. MARCELEGO NENCKIEGO (Poland)
MEDVENTURES SP.Z O.O (Poland)
PRO SCIENCE POLSKA SP. Z O.O. (Poland)
Inventor
Sachadyn, Paweł
Sosnowski, Paweł
Sass, Piotr
Podolak-Popinigis, Justyna
Górnikiewicz, Bartosz
Czupryn, Artur
Janus, Łukasz
Mucha, Piotr
Pikuła, Michał
Piotrowski, Arkadiusz
Skowron, Piotr
Rodziewicz-Motowidło, Sylwia
Abstract
In one aspect, the present invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject. In another aspect the present invention provides zebularine as a therapeutic agent, optionally in combination with retinoic acid, for use in promoting regeneration and healing of wounds resulting from mechanical injuries and/or chemical injuries and/or burns and/or radiation injuries and/or surgical operations and/or other pathological conditions.
A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
The method of performing a biopsy of a soft (especially human) tissue is characterized by the fact that in the working phase in a cutting sleeve (1) or on a cutting sleeve (1) equipped with a cutting bit (20), the tie (3) arranges itself in such a way that from the side of cutting inside the cutting sleeve, from a middle part of the tie (3), and forms a cutting loop. On the opposite side of the cutting site, the ends of the tie are taken outside the cutting sleeve (1). During the active phase the cutting sleeve (1) is pushed into the patient's body up to the decided depth and in this position the ends of the tie (3) are pulled until the moment when the cutting loop tightens and the cutting sleeve (1) is pulled out from the patient's body. The device to perform a biopsy of a soft (especially human) tissue is characterized by the fact that it has a cutting system (T) consisting of a cutting sleeve (1) with a cutting edge (2) and a cutting bit (20) which is detachable. On the internal surface of the cutting sleeve (1) close to the cutting edge (2) there is a peripheral channel (4) which is connected by a pass-through hole (5) with a longitudinal groove (6). In a peripheral channel (4), in a pass-through hole (5) and in a longitudinal groove (6) there is a tie (3) whose ends lead out of the cutting system (T). The device is equipped with a drive system (N) to which the ends of the tie (3) from the cutting system (T) are led. The drive system (N) consists of a casing (8) which is the detachable cutting system (T) is set. The casing (8) has a bracket (9). On the bracket there is a propeller (10) as well as a locking screw (11) fixing its position. The ends of the tie (3) are led through the pass-through hole in the casing (8) and fixed to the pins (12) of the propeller (10).
A61B 10/02 - Instruments for taking cell samples or for biopsy
21.
METHOD FOR DETERMINING BISPHENOL A IN BIOLOGICAL MATERIAL, DIAGNOSTIC DEVICE FOR DETECTION OF BISPHENOL A IN BIOLOGICAL MATERIAL, DIAGNOSTIC KIT FOR DETECTION OF BISPHENOL A IN BIOLOGICAL MATERIAL
NARODOWY INSTYTUT ZDROWIA PUBLICZNEGO - PANSTWOWY ZAKŁAD HIGIENY (Poland)
Inventor
Rutkowska, Aleksandra
Konieczna, Aleksandra
Namiesnik, Jacek
Kudlak, Blazej
Ludwicki, Jan, Krzysztof
Goralczyk, Katarzyna
Strucinski, Pawel
Milewicz, Andrzej
Graczyk, Szymon
Abstract
Method for determining bisphenol A in biological material that relies on binding BPA from biological material with antibodies against bisphenol A and subsequent quantitative determining of BPA content, characterized in that, a migration membrane is being prepared to determine BPA from the migrating biological material so that the membrane is divided into at least a zone of binding with a carrier, a detection zone and a control zone. Color medium covered with monoclonal or polyclonal antibodies against BPA is placed at the zone of binding with the carrier. The detection zone is divided into at least two detection areas while at the first detection area a selected concentration of antibodies against BPA is adsorbed so that BPA can be detected in the range of 0.5 ng/mL to 50 ng/mL and on the second detection area selected concentration of antibodies against BPA is adsorbed so that BPA can be detected in the 0.5 ng/mL to 50 ng/mL. On the control zone monoclonal or polyclonal antibodies against monoclonal or polyclonal antibodies against BPA. Analysed biological material is being applied at the zone of binding with carrier wherein in case of BPA presence, the BPA is being bound with color medium and thus the created complexes of BPA-color medium are directed into the detection zone in which the complexes of BPA-color medium are bound to the antibodies against BPA while the color medium not bound with BPA are directed to the control zone where the color medium is bound with the antibodies against antibodies against BPA. BPA presence is determined by color indication in at least one detection area of the detection zone and by determination of color at the control zone.
05 - Pharmaceutical, veterinary and sanitary products
16 - Paper, cardboard and goods made from these materials
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceuticals; Elixirs [pharmaceutical preparations]; Chemico-pharmaceutical preparations; Pharmaceutical preparations for wounds; Pharmaceutical preparations and substances; Tissue-regenerative pharmaceutical preparations; Pharmacological preparations for skin care; Chemical preparations for pharmaceutical purposes; Amino acid preparations for pharmaceutical use; Pharmaceutical preparations for use in dermatology; Pharmaceutical preparations for treating skin disorders; Pharmaceutical preparations for the treatment of viral diseases; Pharmaceutical preparations for treating epidermal problems; Pharmaceutical preparations for the treatment of inflammatory diseases; Portable first-aid kits; Medicine cases, portable, filled; First aid kits for domestic use; Genetic identity tests comprised of reagents for medical purposes; Medical diagnostic reagents and assays for testing of body fluids; Bandages for dressings; Sanitary wear; Compresses; Elastic bandages [dressings]; Bandages for skin wounds; Sterile plastic films for use as bandaging; Dermatological pharmaceutical products; Chemicals for pharmaceutical use. Paper; Gummed paper; Glassine paper; Art paper; Fine paper; Paper stock; Xerographic paper; Copying paper [stationery]; Fluorescent paper; Parchment paper; Notepaper; Tablecloths of paper; Paper ribbons, other than haberdashery or hair decorations; Paper emblems; Paper boxes; Conical paper bags; Paper tapes; Paper folders; Coasters of paper; Paper patterns; Filler paper; Drip mats of paper; Place mats of paper; Paper sacks; Envelope paper; Paper and cardboard; Publication paper; Magazine paper; Paper-clips; Punches [office requisites]; Paperweights; Labels of paper; Loose leaf paper; Paper clasps; Placards of paper; Handkerchiefs of paper; Advertising signs of paper; Paper stationery; Paper name badges; Printed paper labels; Paper passe-partouts; Blank paper notebooks; Paper teaching materials; Printed paper invitations; Pocket books [stationery]; Gift stationery; Announcement cards [stationery]; Thumbtacks [stationery]; Folders [stationery]; Clips for offices; Pads [stationery]; Office paper stationery; Letter paper [finished products]; Digital printing paper; Laser printing paper; Writing paper; Posters made of paper; Broadsheets; Display banners of paper; Carrying cases made of paper; Adhesive labels of paper; Advertisement boards of paper; Cartons of cardboard for packaging; Containers of paper for packaging purposes; Paper gift bags; Printed advertising boards of paper; Paper envelopes for packaging; Paper file jackets; Paper mail pouches; Paper report covers; Writing stationery; Self-adhesive tapes for stationery use; Adhesive pads [stationery]; Party stationery; Index cards [stationery]; Covers [stationery]; Business card paper [semi-finished]; Bond paper; Paper sheets [stationery]; Paper shredders for office use; Writing paper holders; Labels of paper or cardboard; Paper fasteners; Printed packaging materials of paper; Paper sheets for note taking; Face cloths made of paper; Pencil ornaments [stationery]; Placards of paper or cardboard; Signboards of paper or cardboard; Printed matter; Forms, printed; Photographs [printed]; Signed photographs; Office binders; Adhesives for stationery; Electric hole punches; Handheld label printers [office requisites]; Printed training materials; Educational equipment; Teaching materials [except apparatus]; Books; Gift books; Manuals [handbooks]; Educational books; Pamphlets; Printed brochures; Agendas; Desk diaries; Daily planners; Pocket diaries; Desk top planners; Wall planners; Planners [printed matter]; Bulletins; Printed teaching materials; Printed educational materials; Printed stationery; Printed manuals; Manuals for instructional purposes; Notepads; Note books; Note pads; Writing cases [sets]; Pencils; Pencil cups; Pens; Leaflets; Instruction sheets; Advertising pamphlets; Printed leaflets; Printed informational cards; Posters. Quality control testing; Bacteriological research and testing; Genetic testing of laboratory animals for research purposes; Biological analysis; Analytical laboratory services; Chemical analysis; Technological analysis services; Computer aided scientific analysis services; Scientific research and analysis; Bacteriological research and analysis; Industrial analysis and research services; Scientific research; Research laboratories; Engineering research; Chemical research; Technical research; Research relating to biotechnology; Genetic research; Research relating to technology; Microbiological testing; Chemical analytical examinations; Product research and development; Research and development of new products for others; Research and development of new products; Research and development in the pharmaceutical and biotechnology fields; Expert opinion relating to technology; Product testing; Testing of chemicals; New products (Testing of -); Testing of pharmaceuticals; Product research; Research to develop new products.
23.
ASYMMETRIC BIS-ACRIDINES WITH ANTITUMOUR ACTIVITY AND THEIR USES
We disclose novel asymmetric bis-acridines with antitumour activity. These compounds are useful for use in pharmaceuticals, particularly in the treatment or the prevention of neoplasms.
C07D 219/10 - Nitrogen atoms attached in position 9
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
We disclose novel asymmetric bis-acridines with antitumour activity. These compounds are useful for use in pharmaceuticals, particularly in the treatment or the prevention of neoplasms.
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
25.
DEVICE FOR PHOTOCATALYTIC REMOVAL OF VOLATILE ORGANIC AND INORGANIC CONTAMINATION AS WELL AS MICROORGANISMS ESPECIALLY FROM AUTOMOBILE AIR CONDITIONING SYSTEMS
The device for photocatalytic removal of volatile organic and inorganic contaminations as well as microorganisms especially from air conditioning systems of mechanical vehicles consisting of a plate element applied with a photocatalytic layer as well as a load-carrying element holding a light source in the form of LED diodes emitting UV light, preferably UV-A and/or UV-C, given that between the load-carrying element and the plate element created there is an arterial space, while the light source is mainly directed towards the layer in which the plate element (1) is isolated from the load-carrying element (2) with at least one spacer element (3), preferably applied with a photocatalytic layer. Preferably the external load-carrying element (2) or the external plate element (1) is equipped with a fastening element and the light source (7) consists of LEDs emitting UV is light with wavelength from 410 to 460 nm. The photocatalyst consists of nanotubes made of titanium dioxide modified with metals, preferably precious metals, obtained electro-chemically or nanocomposites made of titanium dioxide modified with metals, preferably precious metals, received using the microemulsive method.
METHOD OF PRODUCTION OF A MATERIAL WITH PHOTOCATALYTIC AND BIOCIDAL PROPERTIES CONTAINING SPATIALLY ORIENTED TITANIUM DIOXIDE NANOTUBES MODIFIED WITH METALS, PARTICULARLY PRECIOUS METALS
Method of production of a material with photocatalytic and biocidal properties containing spatially oriented titanium dioxide nanotubes modified with metals, particularly precious metals. The method of production of a material with photocatalytic and biocidal properties containing spatially oriented titanium dioxide nanotubes modified with metals, particularly precious metals, consisting in being subjected to induced electric current placed in an electrolyte containing ammonium fluoride and ethylene glycol of the base containing titanium, preferably titanium foil, cleaning the obtained material with ultrasounds and then drying and calcinating is characterised according to the invention by the fact that the received material is placed in a multi-component solution, preferably in the neutral gas atmosphere. A multi-component solution must contain 30-50% of alcohol by weight, preferably isopropanol, as well as ions and/or nanomolecules of one or several metals, preferably two or three, selected from the groups including silver, gold, platinum, palladium, ruthenium, copper, zinc, nickel, rhodium, tungsten, cobalt, iron in the amount of 0.05 - 5% of the weight each as well as water. The mutual weight ratio of the metals is determined to be between 1: 1 and 1: 10. Preferably the multi-component solution is mixed in darkroom conditions for 3-180 min, preferably 120 min. Next, it is irradiated with an UV-emitting lamps for 0.5-6 hrs, dried at the temperature of 60 - 100° C for 0.5 - 24 hrs, favourably for 6 -12 hrs.
C23C 18/16 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by reduction or substitution, i.e. electroless plating
B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
C25D 11/26 - Anodisation of refractory metals or alloys based thereon
C23C 18/08 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of metallic material
C23C 18/14 - Decomposition by irradiation, e.g. photolysis, particle radiation
C23C 18/44 - Coating with noble metals using reducing agents
27.
THE METHOD OF OBTAINING THE AQUEOUS SOLUTION OF CHITOSAN, CHITOSAN COMPOSITION, CHITOSAN AEROSOL, THE METHOD OF PRODUCING THE CHITOSAN HYDROGEL MEMBRANE AND THE METHOD OF PRODUCING CHITOSAN-PROTEIN BIOPOLYMER MATERIAL
The object of the invention is a method of obtaining the aqueous solution of chitosan and its application in the form of chitosan composition and chitosan aerosol, characterised in that the obtained solution of chemically non-modified microcrystalline chitosan, after neutralization and separation from acidic chitosan solution is replenished with water and then mixed, while during the mixing process the solution is saturated with inorganic acidic oxides, preferably carbon dioxide, until obtaining clear chitosan solution and dissolving chitosan. The object of the invention is also a method of producing chitosan hydrogel membrane characterised in that the aqueous solution of chitosan obtained according to the invention is poured to the mould and then conditioned preferably at a room temperature, under atmospheric pressure conditions. The object of the invention is also a method of producing chitosan-protein biopolymer material characterised in that the aqueous solution of chitosan obtained according to the invention, is mixed with modification additives such as cross-linking compounds, plasticisers, biologically active substances, preserving agents, and then mixed with a dispersion of collagen and/or gelatin, formed, incubated and conditioned according to a known method. Such chitosan-protein biopolymer material can be dried under atmospheric pressure conditions or by lyophilisation, and conditioned according to a known method.
A process for the synthesis of 1-hydroxy-3-(N-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate which consists in the reaction of phosphorus trichloride with an aqueous solution of 3-(N-methylpentylamino)propionic acid hydrochloride at a temperature of 0-80°C, removing excess unreacted phosphorus trichloride, hydrolysis of the reaction mixture under reflux, conversion of 1-hydroxy-3-(N- methylpentylamino) propylidene bisphosphonic acid into its monosodium salt using sodium cation-containing alkaline substances, crystallisation using an anti-solvent. Also disclosed is a process for the synthesis of a polymorphic form of 1-hydroxy-3-(N-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate which consists of initiating and carryout the crystallisation using acetone at a temperature of 0-5°C.
A process for the preparation of [1-hydroxy-2-(1H-imidazol-1-yl)- ethylidene]bisphosphonic acid consists of the reaction of aqueous solution of 1Η-imidazole-1-acetic acid hydrochloride with phosphorus trichloride followed by removal of the excess of phosphorus trichloride, addition of water and hydrolysis of the reaction products. In order to isolate the product the post-reaction mixture is filtered and the anti-solvent is added to the aqueous filtrate in order to crystallize out [1-hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid monohydrate.
A method for the estimation of the disturbances in an observer of a speed of an induction motor consisting in measuring of components x and y of vectors of voltage and of stator current determined in Cartesian coordinate system fixed to the stator, estimating the values of the components x and y of a stator current vector and comparing with actual, measured values of the components of a stator current, estimating of the components x and y of a rotor flux vector, estimating the angular speed of the rotor is characterized according to the present invention by estimating the components x and y of the disturbances (zx, zy) in a system realizing the following relation: (I) (II) on the basis of measured components of a stator current vector (isx, isy), estimated components of a stator current vector ( isx, isy ),estimated angular speed of a rotor (ωr),estimated components of a rotor flux vector (ψrx,ψry ) and the value of the increment of the estimated angular speed (Δω ) in time (Ts) between two succesive measurements of components of a stator current (isx, isy).
H02P 21/00 - Arrangements or methods for the control of electric machines by vector control, e.g. by control of field orientation
H02P 21/13 - Observer control, e.g. using Luenberger observers or Kalman filters
H02P 21/14 - Estimation or adaptation of machine parameters, e.g. flux, current or voltage
31.
PHOTOREACTOR AND METHOD AND SYSTEM FOR SANITARY AND DOMESTIC SEWAGE AND BILGE SEWAGE WATER TREATMENT GENERATED ESPECIALLY ON SMALL AND MEDIUM WATERCRAFTS OR DRILLING PLATFORMS
Photoreactor for sanitary and domestic sewage and bilge sewage water treatment generated especially on small and medium watercrafts or drilling platforms fitted with reaction chamber covered with UV- Vis light permeable layer with internally located photocatalyst is characterized according to the invention in that the photocatalyst is modified titanium dioxide(IV). The dioxide is the product achieved through heating process of titanium hydroxide (IV) blended with non metals and/or nanoparticles of precious metals. The method is characterized according to the invention by making the sewage solution the subject to photocatalytic process in the photoreactor with modified titanium dioxide (IV) as the photocatalyst. The system according to the invention is characterized by comprising of at least two slop tanks (3 a, 3 b), connected in parallel by means of a pump (4) and aeration device (5) with the photoreactor (1). The photocatalyst in the photoreactor is modified titanium dioxide (IV).
A method of acoustic echo cancellation in the VoIP terminal using processing of the far-end signal with the digital adaptive filter in order to obtain the echo estimate that is subtracted from the microphone signal in which the far- end signal, before it is converted to the analog form and passed to the loudspeaker (4), is marked by embedding an encoded digital signature obtained from the signature generator (14) and then detection of the digital signature is performed in the signal collected by the microphone (7) and converted to digital form, depending on the result of the digital signature detection, adaptation of the digital adaptive filter (9) is resumed or stopped. A circuit for acoustic echo cancellation in VoIP terminal contains the digital adaptive filter with the control block situated between the far-end speech signal path and the near-end speech signal path, and the double-talk detector (1 1 ) that comprises the signature generator ( 14) connected by the signature encoder (15) to the signature embedding block (16) that is situated between the speech decoder (2) and the digital-to-analog converter (3) in the far-end speech signal path. The signature generator (14) is also connected to the signature decoder (17) which is connected to the output of the analog-to-digital converter (8) in the near-end speech signal path and the output of the signature decoder ( 17) is connected by the decision block ( 18) to the control block (10) of the digital adaptive filter (9).
H04B 3/23 - Reducing echo effects or singingOpening or closing transmitting pathConditioning for transmission in one direction or the other using a replica of transmitted signal in the time domain, e.g. echo cancellers
H04M 9/08 - Two-way loud-speaking telephone systems with means for conditioning the signal, e.g. for suppressing echoes for one or both directions of traffic
