Polyphor Ltd.

Switzerland

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IPC Class
C07K 7/64 - Cyclic peptides containing only normal peptide links 12
A61K 38/12 - Cyclic peptides 11
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids 9
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids 8
C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid 7
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Found results for  patents

1.

Template-fixed peptidomimetics

      
Application Number 17013111
Grant Number 11421001
Status In Force
Filing Date 2020-09-04
First Publication Date 2020-12-24
Grant Date 2022-08-23
Owner
  • UNIVERSITAET ZUERICH (Switzerland)
  • POLYPHOR LTD. (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

IPC Classes  ?

  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
  • A61K 38/12 - Cyclic peptides
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • A61K 38/00 - Medicinal preparations containing peptides

2.

Template-fixed peptidomimetics

      
Application Number 16190459
Grant Number 10787486
Status In Force
Filing Date 2018-11-14
First Publication Date 2019-04-04
Grant Date 2020-09-29
Owner
  • UNIVERSITAET ZUERICH (Switzerland)
  • POLYPHOR LTD. (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

IPC Classes  ?

  • A61K 38/12 - Cyclic peptides
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
  • A61K 38/00 - Medicinal preparations containing peptides

3.

Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity

      
Application Number 16130520
Grant Number 10562933
Status In Force
Filing Date 2018-09-13
First Publication Date 2019-01-03
Grant Date 2020-02-18
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITAT ZURICH (Switzerland)
Inventor
  • Demarco, Steven J.
  • Moehle, Kerstin
  • Henze, Heiko
  • Sellier, Odile
  • Jung, Francoise
  • Gombert, Frank
  • Obrecht, Daniel
  • Ludin, Christian

Abstract

Template-fixed β-hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • A61K 38/12 - Cyclic peptides
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
  • A61K 38/00 - Medicinal preparations containing peptides

4.

Template-fixed peptidomimetics

      
Application Number 15851270
Grant Number 10144765
Status In Force
Filing Date 2017-12-21
First Publication Date 2018-05-10
Grant Date 2018-12-04
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITAET ZUERICH (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

IPC Classes  ?

  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • A61K 38/12 - Cyclic peptides
  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
  • A61K 38/00 - Medicinal preparations containing peptides

5.

Template-fixed peptidomimetics

      
Application Number 15379820
Grant Number 09879047
Status In Force
Filing Date 2016-12-15
First Publication Date 2017-04-06
Grant Date 2018-01-30
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITAET ZUERICH (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

IPC Classes  ?

  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • A61K 38/12 - Cyclic peptides
  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
  • A61K 38/00 - Medicinal preparations containing peptides

6.

Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity

      
Application Number 15170233
Grant Number 10100084
Status In Force
Filing Date 2016-06-01
First Publication Date 2016-11-17
Grant Date 2018-10-16
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITAT ZURICH (Switzerland)
Inventor
  • Demarco, Steven J.
  • Moehle, Kerstin
  • Henze, Heiko
  • Sellier, Odile
  • Jung, Francoise
  • Gombert, Frank
  • Obrecht, Daniel
  • Ludin, Christian

Abstract

Template-fixed β-hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • A61K 38/14 - Peptides containing saccharide radicalsDerivatives thereof
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
  • A61K 38/00 - Medicinal preparations containing peptides

7.

Template-fixed peptidomimetics

      
Application Number 14555796
Grant Number 09556234
Status In Force
Filing Date 2014-11-28
First Publication Date 2015-03-19
Grant Date 2017-01-31
Owner
  • Polyphor Ltd. (Switzerland)
  • Universitaet Zuerich (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

IPC Classes  ?

  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • A61K 38/12 - Cyclic peptides

8.

Template-fixed peptidomimetics

      
Application Number 13764099
Grant Number 08921325
Status In Force
Filing Date 2013-02-11
First Publication Date 2013-06-13
Grant Date 2014-12-30
Owner
  • Polyphor Ltd. (Switzerland)
  • Universität Zürich (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.

IPC Classes  ?

  • A61K 38/12 - Cyclic peptides
  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

9.

Template-fixed peptidomimetics

      
Application Number 12528926
Grant Number 08399611
Status In Force
Filing Date 2007-02-28
First Publication Date 2010-02-25
Grant Date 2013-03-19
Owner
  • Polyphor Ltd. (Switzerland)
  • Universitaet Zuerich (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steven J.
  • Ludin, Christian
  • Vrijbloed, Jan Wim
  • Moehle, Kerstin
  • Robinson, John-Anthony
  • Mukherjee, Reshmi
  • Henze, Heiko
  • Romagnoli, Barbara

Abstract

DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or for treating inflammation, or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor.

IPC Classes  ?

  • A61K 38/12 - Cyclic peptides
  • A61K 38/10 - Peptides having 12 to 20 amino acids
  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof

10.

Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity

      
Application Number 11816589
Grant Number 08658604
Status In Force
Filing Date 2005-02-17
First Publication Date 2009-02-26
Grant Date 2014-02-25
Owner
  • Polyphor Ltd (Switzerland)
  • Universitat Zurich (Switzerland)
Inventor
  • Demarco, Steven J.
  • Moehle, Kerstin
  • Henze, Heiko
  • Sellier, Odile
  • Jung, Françoise
  • Gombert, Frank
  • Obrecht, Daniel
  • Ludin, Christian

Abstract

Template-fixed β-hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

11.

TEMPLATE-FIXED PEPTIDOMIMETICS

      
Application Number CH2007000101
Publication Number 2008/104090
Status In Force
Filing Date 2007-02-28
Publication Date 2008-09-04
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITÄT ZÜRICH (Switzerland)
Inventor
  • Demarco, Steven, J.
  • Mukherjee, Reshmi
  • Moehle, Kerstin
  • Robinson, John, Anthony
  • Henze, Heiko
  • Romagnoli, Barbara
  • Obrecht, Daniel
  • Gombert, Frank
  • Ludin, Christian
  • Vrijbloed, Jan, Wim

Abstract

The template-fixed ß-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro- Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting fromCXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilisation of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.

IPC Classes  ?

  • C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
  • A61K 38/12 - Cyclic peptides

12.

TEMPLATE-FIXED PEPTIDOMIMETICS

      
Application Number CH2007000038
Publication Number 2008/092281
Status In Force
Filing Date 2007-01-29
Publication Date 2008-08-07
Owner POLYPHOR LTD. (Switzerland)
Inventor
  • Obrecht, Daniel
  • Gombert, Frank
  • Demarco, Steve, J.
  • Ludin, Christian
  • Sellier-Kessler, Odile
  • Jung, Françoise
  • Mukherjee, Reshmi
  • Romagnoli, Barbara
  • Henze, Heiko
  • Lederer, Alex
  • Bisang, Christian

Abstract

Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 4 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to agonize or to antagonize GPCR receptors such as CXCR3, urotensin and CCR10. They can be used as medicaments to treat or prevent diseases such as cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, inflammatory diseases, neurological diseases, respiratory diseases, haematological diseases and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • C07K 5/10 - Tetrapeptides
  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

13.

TEMPLATE-FIXED PEPTIDOMIMETICS

      
Document Number 02637377
Status In Force
Filing Date 2007-01-15
Open to Public Date 2007-07-19
Grant Date 2016-03-22
Owner
  • UNIVERSITAET ZUERICH (Switzerland)
  • POLYPHOR LTD. (Switzerland)
Inventor
  • Gombert, Frank
  • Obrecht, Daniel
  • Vrijbloed, Wim
  • Dias, Ricardo
  • Demarco, Steve J.
  • Robinson, John Anthony
  • Srinivas, Nityakalyani

Abstract

Template-fixed .beta.-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 .alpha.-amino acid residues which, depending on their positions in the chain (counted starting firom the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and Solution phase synthetic strategy.

IPC Classes  ?

  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

14.

TEMPLATE - FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY

      
Application Number CH2006000036
Publication Number 2007/079597
Status In Force
Filing Date 2006-01-16
Publication Date 2007-07-19
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITÄT ZÜRICH (Switzerland)
Inventor
  • Robinson, John, Anthony
  • Srinivas, Nityakalyani
  • Gombert, Frank
  • Obrecht, Daniel
  • Vrijbloed, Wim
  • Dias, Ricardo
  • Demarco, Steve, J.

Abstract

Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof

15.

TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY

      
Application Number CH2007000017
Publication Number 2007/079605
Status In Force
Filing Date 2007-01-15
Publication Date 2007-07-19
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITÄT ZÜRICH (Switzerland)
Inventor
  • Gombert, Frank
  • Obrecht, Daniel
  • Vrijbloed, Wim
  • Dias, Ricardo
  • Demarco, Steve, J.
  • Robinson, John, Anthony
  • Srinivas, Nityakalyana

Abstract

Template-fixed &bgr;-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 &agr;-amino acid residues which, depending on their positions in the chain (counted starting firom the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These &bgr;-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and Solution phase synthetic strategy.

IPC Classes  ?

  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof

16.

TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY

      
Document Number 02915175
Status In Force
Filing Date 2005-02-17
Open to Public Date 2006-08-24
Grant Date 2019-04-09
Owner
  • UNIVERSITAT ZURICH (Switzerland)
  • POLYPHOR LTD. (Switzerland)
Inventor
  • Demarco, Steven J.
  • Moehle, Kerstin
  • Henze, Heiko
  • Sellier, Odile
  • Jung, Francoise
  • Gombert, Frank
  • Obrecht, Daniel
  • Ludin, Christian

Abstract

Templates-fixed .beta.-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11 a-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links
  • C07K 14/81 - Protease inhibitors

17.

TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY

      
Document Number 03035941
Status In Force
Filing Date 2005-02-17
Open to Public Date 2006-08-24
Grant Date 2021-11-16
Owner
  • POLYPHOR LTD. (Switzerland)
  • UNIVERSITAT ZURICH (Switzerland)
Inventor
  • Gombert, Frank
  • Demarco, Steven J.
  • Jung, Francoise
  • Ludin, Christian
  • Obrecht, Daniel
  • Sellier, Odile
  • Moehle, Kerstin
  • Henze, Heiko

Abstract

Templates-fixed 13-hairpin peptidomimetics of the general formulae (1), wherein Z is a chain of 11 a-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These I3-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • A61K 38/08 - Peptides having 5 to 11 amino acids
  • A61K 38/12 - Cyclic peptides
  • A61K 38/55 - Protease inhibitors
  • C07K 1/04 - General processes for the preparation of peptides on carriers
  • C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 14/81 - Protease inhibitors

18.

TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY

      
Document Number 02598360
Status In Force
Filing Date 2005-02-17
Open to Public Date 2006-08-24
Grant Date 2016-12-20
Owner
  • UNIVERSITAT ZURICH (Switzerland)
  • POLYPHOR LTD. (Switzerland)
Inventor
  • Demarco, Steven J.
  • Moehle, Kerstin
  • Henze, Heiko
  • Sellier, Odile
  • Jung, Francoise
  • Gombert, Frank
  • Obrecht, Daniel
  • Ludin, Christian

Abstract

Templates-fixed .beta.-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11 .alpha.-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

IPC Classes  ?

  • A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
  • C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
  • C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
  • C07K 7/64 - Cyclic peptides containing only normal peptide links