|
Found results for
patents
1.
|
Template-fixed peptidomimetics
Application Number |
17013111 |
Grant Number |
11421001 |
Status |
In Force |
Filing Date |
2020-09-04 |
First Publication Date |
2020-12-24 |
Grant Date |
2022-08-23 |
Owner |
- UNIVERSITAET ZUERICH (Switzerland)
- POLYPHOR LTD. (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
IPC Classes ?
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A61K 38/12 - Cyclic peptides
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- A61K 38/00 - Medicinal preparations containing peptides
|
2.
|
Template-fixed peptidomimetics
Application Number |
16190459 |
Grant Number |
10787486 |
Status |
In Force |
Filing Date |
2018-11-14 |
First Publication Date |
2019-04-04 |
Grant Date |
2020-09-29 |
Owner |
- UNIVERSITAET ZUERICH (Switzerland)
- POLYPHOR LTD. (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
IPC Classes ?
- A61K 38/12 - Cyclic peptides
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A61K 38/00 - Medicinal preparations containing peptides
|
3.
|
Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
Application Number |
16130520 |
Grant Number |
10562933 |
Status |
In Force |
Filing Date |
2018-09-13 |
First Publication Date |
2019-01-03 |
Grant Date |
2020-02-18 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITAT ZURICH (Switzerland)
|
Inventor |
- Demarco, Steven J.
- Moehle, Kerstin
- Henze, Heiko
- Sellier, Odile
- Jung, Francoise
- Gombert, Frank
- Obrecht, Daniel
- Ludin, Christian
|
Abstract
Template-fixed β-hairpin peptidomimetics of the general formulae
wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- A61K 38/12 - Cyclic peptides
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
- A61K 38/00 - Medicinal preparations containing peptides
|
4.
|
Template-fixed peptidomimetics
Application Number |
15851270 |
Grant Number |
10144765 |
Status |
In Force |
Filing Date |
2017-12-21 |
First Publication Date |
2018-05-10 |
Grant Date |
2018-12-04 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITAET ZUERICH (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
IPC Classes ?
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- A61K 38/12 - Cyclic peptides
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A61K 38/00 - Medicinal preparations containing peptides
|
5.
|
Template-fixed peptidomimetics
Application Number |
15379820 |
Grant Number |
09879047 |
Status |
In Force |
Filing Date |
2016-12-15 |
First Publication Date |
2017-04-06 |
Grant Date |
2018-01-30 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITAET ZUERICH (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
IPC Classes ?
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- A61K 38/12 - Cyclic peptides
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A61K 38/00 - Medicinal preparations containing peptides
|
6.
|
Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
Application Number |
15170233 |
Grant Number |
10100084 |
Status |
In Force |
Filing Date |
2016-06-01 |
First Publication Date |
2016-11-17 |
Grant Date |
2018-10-16 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITAT ZURICH (Switzerland)
|
Inventor |
- Demarco, Steven J.
- Moehle, Kerstin
- Henze, Heiko
- Sellier, Odile
- Jung, Francoise
- Gombert, Frank
- Obrecht, Daniel
- Ludin, Christian
|
Abstract
Template-fixed β-hairpin peptidomimetics of the general formulae
wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- A61K 38/14 - Peptides containing saccharide radicalsDerivatives thereof
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
- A61K 38/00 - Medicinal preparations containing peptides
|
7.
|
Template-fixed peptidomimetics
Application Number |
14555796 |
Grant Number |
09556234 |
Status |
In Force |
Filing Date |
2014-11-28 |
First Publication Date |
2015-03-19 |
Grant Date |
2017-01-31 |
Owner |
- Polyphor Ltd. (Switzerland)
- Universitaet Zuerich (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
IPC Classes ?
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- A61K 38/12 - Cyclic peptides
|
8.
|
Template-fixed peptidomimetics
Application Number |
13764099 |
Grant Number |
08921325 |
Status |
In Force |
Filing Date |
2013-02-11 |
First Publication Date |
2013-06-13 |
Grant Date |
2014-12-30 |
Owner |
- Polyphor Ltd. (Switzerland)
- Universität Zürich (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.
IPC Classes ?
- A61K 38/12 - Cyclic peptides
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
|
9.
|
Template-fixed peptidomimetics
Application Number |
12528926 |
Grant Number |
08399611 |
Status |
In Force |
Filing Date |
2007-02-28 |
First Publication Date |
2010-02-25 |
Grant Date |
2013-03-19 |
Owner |
- Polyphor Ltd. (Switzerland)
- Universitaet Zuerich (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steven J.
- Ludin, Christian
- Vrijbloed, Jan Wim
- Moehle, Kerstin
- Robinson, John-Anthony
- Mukherjee, Reshmi
- Henze, Heiko
- Romagnoli, Barbara
|
Abstract
DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or for treating inflammation, or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor.
IPC Classes ?
- A61K 38/12 - Cyclic peptides
- A61K 38/10 - Peptides having 12 to 20 amino acids
- A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
|
10.
|
Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
Application Number |
11816589 |
Grant Number |
08658604 |
Status |
In Force |
Filing Date |
2005-02-17 |
First Publication Date |
2009-02-26 |
Grant Date |
2014-02-25 |
Owner |
- Polyphor Ltd (Switzerland)
- Universitat Zurich (Switzerland)
|
Inventor |
- Demarco, Steven J.
- Moehle, Kerstin
- Henze, Heiko
- Sellier, Odile
- Jung, Françoise
- Gombert, Frank
- Obrecht, Daniel
- Ludin, Christian
|
Abstract
Template-fixed β-hairpin peptidomimetics of the general formulae
wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
|
11.
|
TEMPLATE-FIXED PEPTIDOMIMETICS
Application Number |
CH2007000101 |
Publication Number |
2008/104090 |
Status |
In Force |
Filing Date |
2007-02-28 |
Publication Date |
2008-09-04 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITÄT ZÜRICH (Switzerland)
|
Inventor |
- Demarco, Steven, J.
- Mukherjee, Reshmi
- Moehle, Kerstin
- Robinson, John, Anthony
- Henze, Heiko
- Romagnoli, Barbara
- Obrecht, Daniel
- Gombert, Frank
- Ludin, Christian
- Vrijbloed, Jan, Wim
|
Abstract
The template-fixed ß-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro- Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where Cancer is mediated or resulting fromCXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or, in particular, for stem cell mobilisation of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and Solution phase synthetic strategy, using methods which are well known to those adequately skilled in peptide chemistry.
IPC Classes ?
- C07K 7/56 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A61K 38/12 - Cyclic peptides
|
12.
|
TEMPLATE-FIXED PEPTIDOMIMETICS
Application Number |
CH2007000038 |
Publication Number |
2008/092281 |
Status |
In Force |
Filing Date |
2007-01-29 |
Publication Date |
2008-08-07 |
Owner |
POLYPHOR LTD. (Switzerland)
|
Inventor |
- Obrecht, Daniel
- Gombert, Frank
- Demarco, Steve, J.
- Ludin, Christian
- Sellier-Kessler, Odile
- Jung, Françoise
- Mukherjee, Reshmi
- Romagnoli, Barbara
- Henze, Heiko
- Lederer, Alex
- Bisang, Christian
|
Abstract
Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 4 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to agonize or to antagonize GPCR receptors such as CXCR3, urotensin and CCR10. They can be used as medicaments to treat or prevent diseases such as cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, inflammatory diseases, neurological diseases, respiratory diseases, haematological diseases and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- C07K 5/10 - Tetrapeptides
- A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
|
13.
|
TEMPLATE-FIXED PEPTIDOMIMETICS
Document Number |
02637377 |
Status |
In Force |
Filing Date |
2007-01-15 |
Open to Public Date |
2007-07-19 |
Grant Date |
2016-03-22 |
Owner |
- UNIVERSITAET ZUERICH (Switzerland)
- POLYPHOR LTD. (Switzerland)
|
Inventor |
- Gombert, Frank
- Obrecht, Daniel
- Vrijbloed, Wim
- Dias, Ricardo
- Demarco, Steve J.
- Robinson, John Anthony
- Srinivas, Nityakalyani
|
Abstract
Template-fixed .beta.-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 .alpha.-amino acid residues which, depending on their positions in the chain (counted starting firom the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and Solution phase synthetic strategy.
IPC Classes ?
- A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
|
14.
|
TEMPLATE - FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY
Application Number |
CH2006000036 |
Publication Number |
2007/079597 |
Status |
In Force |
Filing Date |
2006-01-16 |
Publication Date |
2007-07-19 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITÄT ZÜRICH (Switzerland)
|
Inventor |
- Robinson, John, Anthony
- Srinivas, Nityakalyani
- Gombert, Frank
- Obrecht, Daniel
- Vrijbloed, Wim
- Dias, Ricardo
- Demarco, Steve, J.
|
Abstract
Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
- A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
|
15.
|
TEMPLATE-FIXED PEPTIDOMIMETICS WITH ANTIMICROBIAL ACTIVITY
Application Number |
CH2007000017 |
Publication Number |
2007/079605 |
Status |
In Force |
Filing Date |
2007-01-15 |
Publication Date |
2007-07-19 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITÄT ZÜRICH (Switzerland)
|
Inventor |
- Gombert, Frank
- Obrecht, Daniel
- Vrijbloed, Wim
- Dias, Ricardo
- Demarco, Steve, J.
- Robinson, John, Anthony
- Srinivas, Nityakalyana
|
Abstract
Template-fixed &bgr;-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12 &agr;-amino acid residues which, depending on their positions in the chain (counted starting firom the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining Symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These &bgr;-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and Solution phase synthetic strategy.
IPC Classes ?
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
- A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
|
16.
|
TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY
Document Number |
02915175 |
Status |
In Force |
Filing Date |
2005-02-17 |
Open to Public Date |
2006-08-24 |
Grant Date |
2019-04-09 |
Owner |
- UNIVERSITAT ZURICH (Switzerland)
- POLYPHOR LTD. (Switzerland)
|
Inventor |
- Demarco, Steven J.
- Moehle, Kerstin
- Henze, Heiko
- Sellier, Odile
- Jung, Francoise
- Gombert, Frank
- Obrecht, Daniel
- Ludin, Christian
|
Abstract
Templates-fixed .beta.-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11 a-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
- C07K 14/81 - Protease inhibitors
|
17.
|
TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY
Document Number |
03035941 |
Status |
In Force |
Filing Date |
2005-02-17 |
Open to Public Date |
2006-08-24 |
Grant Date |
2021-11-16 |
Owner |
- POLYPHOR LTD. (Switzerland)
- UNIVERSITAT ZURICH (Switzerland)
|
Inventor |
- Gombert, Frank
- Demarco, Steven J.
- Jung, Francoise
- Ludin, Christian
- Obrecht, Daniel
- Sellier, Odile
- Moehle, Kerstin
- Henze, Heiko
|
Abstract
Templates-fixed 13-hairpin peptidomimetics of the general formulae (1), wherein Z is a chain of 11 a-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These I3-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- A61K 38/08 - Peptides having 5 to 11 amino acids
- A61K 38/12 - Cyclic peptides
- A61K 38/55 - Protease inhibitors
- C07K 1/04 - General processes for the preparation of peptides on carriers
- C07K 1/06 - General processes for the preparation of peptides using protecting groups or activating agents
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 14/81 - Protease inhibitors
|
18.
|
TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH PROTEASE INHIBITORY ACTIVITY
Document Number |
02598360 |
Status |
In Force |
Filing Date |
2005-02-17 |
Open to Public Date |
2006-08-24 |
Grant Date |
2016-12-20 |
Owner |
- UNIVERSITAT ZURICH (Switzerland)
- POLYPHOR LTD. (Switzerland)
|
Inventor |
- Demarco, Steven J.
- Moehle, Kerstin
- Henze, Heiko
- Sellier, Odile
- Jung, Francoise
- Gombert, Frank
- Obrecht, Daniel
- Ludin, Christian
|
Abstract
Templates-fixed .beta.-hairpin peptidomimetics of the general formulae (I), wherein Z is a chain of 11 .alpha.-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which , as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These .beta.-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.
IPC Classes ?
- A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
- C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K 7/64 - Cyclic peptides containing only normal peptide links
|
|