Abstract

Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

IPC Classes  ?

• C07D 227/087 - One doubly-bound oxygen atom in position 2, e.g. lactams
• C07D 501/38 - Methylene radicals, substituted by nitrogen atomsLactams thereof with the 2-carboxyl groupMethylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atomQuaternary compounds thereof
• C07D 201/14 - Preparation of salts or adducts of lactams
• C07H 3/04 - Disaccharides
• C07H 3/02 - Monosaccharides
• A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
• A61K 31/7016 - Disaccharides, e.g. lactose, lactulose
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61P 31/04 - Antibacterial agents
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed herein are novel structures of proteasome inhibitors and methods for synthesizing and use thereof, including novel structures of proteasome inhibitors, such as syrbactins and its analogs, and methods for synthesizing them and using them for effective proteasome inhibition.

IPC Classes  ?

• C07D 225/02 - Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
• C07D 245/02 - Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
• C07D 285/00 - Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups
• C07C 49/307 - Saturated compounds containing keto groups bound to rings to a seven- to twelve-membered ring
• A61P 35/00 - Antineoplastic agents
• A61K 31/33 - Heterocyclic compounds