The present invention relates to a peptide agonist of the Mas, AT1 and AT2 receptors, having amino acid sequence SEQ ID NO: 1, which is useful in preventing and/or treating hypertension, and/or reducing cardiovascular, cerebral, pulmonary and renal vasoconstriction, and/or preventing, reversing, inhibiting and/or reducing the pathological remodelling of cardiovascular, pulmonary, renal and/or cerebral tissue. The invention also relates to a pharmaceutical composition comprising the peptide or a combination of the peptides, useful in preventing and/or treating hypertension, reducing vascular vasoconstriction, and/or preventing, reversing, inhibiting and/or reducing the pathological remodelling of cardiovascular, pulmonary, renal and/or cerebral tissue.
The present invention relates to a novel internal curing agent based on geopolymers from fly ash, which performs the same or better than the alternatives available on the international market, for use in concrete or mortar mixtures. The advantage of the internal curing agent is that it can be manufactured using local materials with a low large-scale production cost and it can be specifically designed for different applications of concrete construction.
C04B 18/00 - Use of agglomerated or waste materials or refuse as fillers for mortars, concrete or artificial stoneTreatment of agglomerated or waste materials or refuse, specially adapted to enhance their filling properties in mortars, concrete or artificial stone
C04B 18/14 - Waste materialsRefuse from metallurgical processes
The present invention relates to the manufacture of aggregates from mine tailings, and to the use of said aggregates, pellets and/or fine aggregates in engineering applications as fillers, bases and sub-bases or in concrete mixtures.
C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
The present invention relates to a method for taking volumetric measurements from volumetric images obtained by a volumetric image capturing device. The method comprises the steps of: guiding the radiation emitted from an object extended over an optical cavity made up of reflective surfaces; and configuring the optical cavity to generate different optical path lengths to the radiation guided by the optical cavity, depending on the starting position of the radiation from the object and on the direction of propagation of the radiation from the object. The described method enhances the resolution and simplifies the complexity of the components compared to other methods for capturing volumetric images. It is used to quickly capture volumetric images to make neurophysiological recordings, release neurotransmitters in the brain and be implemented in other technical fields that require high-speed volumetric measurements, such as illumination with specific volumetric patterns, characterisation of the volumetric light field and time-controlled interferometric measurements.
The present invention relates to the use of a combination of estetrol (E4) and progesterone (P4) to prepare a medicine that is useful in the treatment of endometriosis. The medicine of the invention does not lower progesterone-receptor (PR) levels, but does increase progesterone-receptor levels in endometrial cells, causing the disease to progress more slowly and preventing the development of resistance to treatment.
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61P 15/00 - Drugs for genital or sexual disordersContraceptives
6.
EX VIVO METHOD FOR THE PROGNOSIS OF METASTASIS IN PROSTATE CANCER
Ex vivo method for the prognosis of metastasis in prostate cancer which comprises determining the level of expression of at least one of the following genes: NRP-1, MFAP4, NRIP3, THBS2, TNF, EDN1, EBF1 and GALNT16, in a biological sample that contains stromal cells of a prostate cancer primary tumor; and establish whether the expression of the genes NRP-1, MFAP4, NRIP3, THBS2, TNF, EDN1, EBF1 is increased or if the expression of the GALNT16 gene is diminished, which correlates with the prognosis of metastasis in prostate cancer. And a kit for predicting metastases in prostate cancer comprising means for quantifying the products of the genes NRP-1, MFAP4, NRIP3, THBS2, TNF, EDN1, EBF1 and GALNT16, in a sample comprising prostatic stromal cells.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
7.
METHOD FOR PRODUCING A WINE WITH REDUCED ETHANOL AND IMPROVED ORGANOLEPTIC PROPERTIES FROM CANDIDA YEASTS
The invention relates to a fermentation method for producing wine with reduced ethanol and with improved organoleptic properties using non-Saccharomyces yeasts of the genus Candida, particularly Candida oleophila, Candida boidinii or a mixture thereof. The method involves the inoculation of grape juice with the yeasts and fermentation of the inoculated juice for a period of time between 8 and 20 days. The invention also relates to the yeasts used in said method.
The invention relates to a paving slab and a method of constructing of a paving slab consisting of a rigid concrete structure with a balanced distribution of the volume of concrete. The slab material has a distribution with a smaller thickness of concrete in the centre of the paving and a greater thickness at the edges of the paving.
The invention relates to a pump assembly (1) for an implantable penile prosthetic, where the assembly can be placed between the testicles (T) and comprises a valve component (20) with an actuator (21) to activate it, ducts (23) to communicate with inflatable members and a compressible bulb (10). The bulb (10) limits the rotation of the pump assembly in the scrotal sac and facilitates the haptic recognition of the bulb by the user and the symmetric radial compression of the bulb by preventing it from sliding inside the scrotal sac. The bulb (10) comprises: a set of three vertical stabilising ribs (110, 120, 130) that are equidistantly distributed along the perimeter of a circumferential perimeter portion (12), said ribs comprising a straight prismatic body with a triangular cross section and being made up of first and second flat rectangular vertical walls that are laterally separated from each other and project converging towards a common distal vertical straight edge.
The invention discloses a nutraceutical composition comprising red grape marc flour (GMF) of the Cabernet Sauvignon variety with a high fibre content and dispersible in water. The nutraceutical composition further comprises nutraceutically acceptable ingredients that improve organoleptic and water solubility characteristics, said ingredients being selected from the group consisting of flavouring agents, fluidising agents, sweetening agents and stabilising agents, among others, and maintaining the natural bioactive properties of GMF and thus the acceptability of the product by consumers. The unique properties of this natural nutraceutical composition with high fibre and antioxidant content make it a good alternative for reaching the recommended intake levels of dietary fibre and, in this way, manage glycaemia in diabetic or pre-diabetic patients.
A61K 36/87 - Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
C12F 3/06 - Recovery of by-products from beer or wine
A61P 3/08 - Drugs for disorders of the metabolism for glucose homeostasis
A23L 19/00 - Products from fruits or vegetablesPreparation or treatment thereof
A23L 29/238 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
A23L 29/25 - Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth
The invention relates to fungicide formulations for combating fungal infections in cultures of agronomic interest, comprising an effective quantity of a combination of a biopolymer and a photoactivatable agent. The invention also relates to the production method for said formulations and to the use thereof for combating fungal infections.
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
The present invention relates to compounds derived from 2-benzyloxyphenylethylamines of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the preparation of said compounds by means of a pathway that allows halogenated derivatives to be obtained. The obtained compounds exhibit biological inhibition activity on the human serotonin transporter (hSERT).
C07C 211/02 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
C07D 317/48 - Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/36 - Compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61P 25/00 - Drugs for disorders of the nervous system
The invention relates to a gluten-free composition that serves as a base for producing doughs, dry and fresh pastas, pastry products and other products for baking. The composition comprises quinoa flour and pulse flours, such as chickpea and haricot bean, among others, also being supplemented by quinoa leaf powder, which allows for a product to be obtained with a high protein content and excellent organoleptic properties, achieving good cohesion and elasticity of the dough.
The invention relates to a construction system and construction method for erecting medium-height single- or multi-storey wooden structures, such as single- or two-storey houses, medium-height buildings and sheds, providing the possibility for architectural flexibility in the floor plan. The construction system comprises a structural joint for rigid frames that is formed by I-joist beams and columns, to generate a lightweight structure capable of providing high strength and durability to the wooden structure. The rigid frames comprise porticos with a structure formed by beams and columns made of wooden I-joist elements that define, respectively, sets of columns to demarcate walls and sets of beams to demarcate floors, with a rigid structural joint that allows wooden structures of one or more stories to be erected in order to form medium-height structures.
E04C 3/12 - JoistsGirders, trusses, or truss-like structures, e.g. prefabricatedLintelsTransoms of wood, e.g. with reinforcements, with tensioning members
E04C 3/42 - Arched girders or portal frames of wood, e.g. units for rafter roofs
15.
MULTI-PORT POWER CONVERTER AND ASSOCIATED SYSTEM AND USE
The invention relates to a multi-port power converter and a power conversion system that implements the power converter of the invention to connect at least two elements in direct current (DC) with at least one element in alternating current (AC) using a single simultaneous conversion stage. Furthermore, the invention relates to the use of the power conversion system.
H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
H02M 1/12 - Arrangements for reducing harmonics from AC input or output
H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
H02M 7/797 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
16.
METHOD FOR REDUCING BITTERNESS IN A FUNCTIONAL INGREDIENT BASED ON AVOCADO STONES AND PRODUCT OBTAINED USING THIS METHOD
The present invention relates to a process for obtaining functional ingredients based on seeds/stones that comprises a method for reducing the bitterness of the final obtained product. In particular, the present invention relates to a functional ingredient intended for human food which is obtained based on a processed avocado stone. The processing of the avocado stone reduces the bitter flavour, maintaining a high percentage of polyphenolic compounds present in the final ingredient and its antioxidant and anti-inflammatory properties with a suitable calorie content.
The invention relates to an ergonomically inclusive self-issue station, useful for implementation in libraries or any similar space. The self-issue station comprises a reader, a screen, a desensitising module and a verification device and is designed to facilitate the entire user self-service process while maintaining integrated and reliable management of the catalogue of copies or objects forming part of the library.
FUNDACIÓN CENTRO DE NANOCIENCIA Y NANOTECNOLOGÍA (Chile)
Inventor
Vilos Ortiz, Cristian Andrés
Zacconi, Flavia Cristina Milagro
Salazar Muñoz, Javier Alonso
Abstract
The present invention provides a method for the synthesis of a branched copolymer of hyaluronic acid (HA) and poly(lactic-co-glycolic acid) (PLGA), and the branched copolymer thus obtained (HA-g-PLGA). Said method comprises activating the PLGA with coupling reagents in a water miscible solvent; solubilizing the HA in a phosphate buffered saline solution; and adding the activated PLGA solution dropwise to the solution with HA to obtain the branched copolymer. The advantages of the present method are that it uses environmentally friendly conditions and allows the copolymer to be synthesized and purified in less than a week under laboratory conditions. In addition, the branched copolymer obtained does not present traces of any of the reagents used for its synthesis, so it can be used directly in the development of applications for human use.
The invention provides a nanoencapsulated natural polyphenol composition. These encapsulated polyphenols enable its formulation as a dietary supplement for nutraceuticals, functional foods and/or enriched foods with neuro-protective functionality. In an embodiment of the invention, the polyphenols correspond to tannins derived from grapes. In a preferred embodiment of the invention, the polyphenols or tannins are encapsulated in liposomes. The invention also relates to the method for obtaining the composition. In addition to benefitting health and increasing its bioavailability, the encapsulated polyphenols or tannins allow the stability of foods to be improved, maintaining their physical properties and antioxidants.
The present invention discloses a fining agent for fining beverages rich in phenolic compounds based on a combination of proteins similar to those in human saliva and with high interaction with wine tannins and combined with an autolysed yeast solution. In a preferred embodiment of the invention, the proteins are of a non-animal origin.
C12H 1/02 - Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages combined with removal of precipitate or added materials, e.g. adsorption material
A23L 2/72 - Clarifying or fining of non-alcoholic beveragesRemoving unwanted matter by filtration
A23L 2/84 - Clarifying or fining of non-alcoholic beveragesRemoving unwanted matter using microorganisms or biological material, e.g. enzymes
21.
IN-VITRO METHOD FOR DIAGNOSING AND PREDICTING THE AGGRESSIVENESS OF THYROID CANCER, AND THE PRECISION SURGERY OPTIONS AND TYPE TO BE USED TO REMOVE A TUMOUR FROM A PATIENT; KIT; REAGENTS FORMING THE KIT; AND USE OF THE REAGENTS AND USE OF MOLECULAR MARKERS AS PART OF THE METHOD
An in-vitro method and a kit for diagnosing and predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove a tumor from a patient. Reagents forming the kit and the use of the reagents as part of the kit; markers for predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove the tumor from a patient.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (10%) (Chile)
Inventor
Veloso Giménez, Valentina Del Carmen
Cárdenas Calderón, Camila Valentina
Serrano Canales, Alejandra Rita De Lourdes
Muñoz Silva, Macarena Andrea
Vargas Cucurella, Ignacio Tomás
Abstract
The invention relates to a device (1) for filtering and purifying greywater or other wastewater to generate a new, clean and safe water source, which comprises: a tank (2) for collecting the water to be treated, which includes an inlet or opening (5) to channel the water to be treated, and for discharging the water once filtered and purified; a biocarrier container (3), disposed inside the tank (2), which comprises a plurality of biocarriers containing microorganisms grown to purify the water; and an aerating apparatus to supply oxygen into the tank to promote the aerobic metabolism of the microorganisms and prevent the development of unpleasant odours. The invention also relates to the biocarrier for growing microorganisms for filtering and purifying greywater and other wastewater.
C02F 3/06 - Aerobic processes using submerged filters
23.
IMMUNOGENIC FORMULATION CONTAINING ONE OR MORE MODIFIED BCG STRAINS EXPRESSING A SARS-CoV-2 PROTEIN, USEFUL FOR PREVENTING, TREATING, OR ATTENUATING THE DEVELOPMENT OF COVID-19
The invention relates to an immunogenic formulation containing one or more modified recombinant strains of Bacillus Calmette-Guerin (BCG), in a concentration between 104−109 bacteria, where each BCG strain expresses at least one protein or immunogenic fragment of SARS-CoV-2, in a pharmaceutically acceptable saline buffer, where this formulation serves to prepare vaccines to prevent, treat or attenuate SARS-CoV-2 infections.
IMMUNOGENIC FORMULATION CONTAINING A MODIFIED BCG STRAIN EXPRESSING AN ANDESVIRUS PROTEIN (ANDV) USEFUL FOR PREVENTING AND TREATING HANTA-ANDV VIRUS INFECTIONS
The invention relates to an immunogenic formulation containing the bacillus Calmette-Guerin (BCG) strain in a concentration between 104-109 bacteria, expressing at least one protein or immunogenic fragment of Andesvirus (ANDV), in a pharmaceutically acceptable saline buffer solution, which serves to prepare a vaccine useful for preventing, treating or attenuating ANDV infections. ANDV belongs to the Hantavirus family and is a highly virulent human pathogen, which annually affects dozens of people in Chile generating in some infected a Hantavirus Cardiopulmonary Syndrome (HCPS).
The invention relates to a method for quantifying the astringency of beverages or food based on a composition comprising proteins that are reactive with tannins. The method determines the astringency by means of oral tribology, wherein the proteins used are similar to those of human saliva and are characterised in that they are highly interactive with tannins. The invention further relates to a kit provided to quantify sensorial astringency in food or beverages, preferably in fermented alcoholic beverages by means of the method of the present invention.
Described as an advanced electrolytic oxidation process for stabilising mining effluents having high concentrations of arsenic. Also described are an industrial photoelectrochemical oxidation unit for stabilising the arsenic, which operates continuously; a modular system comprising one, two or more such industrial oxidation units; and the use of the industrial unit.
The present invention relates to the technical field of nanotechnology and pharmaceutics, in particular to a reagent and a pharmaceutical composition containing gold nanorods conjugated with D1 and Angiopep-2 peptides, and methods for detection, diagnosis, evaluating progression, and treatment of diseases related to beta-amyloid plaques, such as Alzheimer's disease. Surprisingly, with the reagent and pharmaceutical composition of the present invention, a dose of gold per kg of body weight well below those previously reported is required, hence the applications thereof are more economical, in addition to decreasing the likelihood of toxic effects, thanks to the low doses required to exert their function.
A61K 47/52 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
28.
PROCESS FOR PRODUCING LITHIUM SALT WITH HIGH LEVEL OF LITHIUM-7 ISOTOPE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE TOULOUSE III - PAUL SABATIER (France)
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (Chile)
Inventor
Thillaye Du Boullay, Olivier
Baceiredo, Jose Antoine
Kato, Tsuyoshi
Rojas Guerrero, René
Abstract
The invention relates to a liquid-solid separation multi-stage process of lithium-6 and lithium-7 isotopes from a solid alkali lithium salt, an organic solution of a macrocycle in a water non-miscible solvent is contacted with a solid lithium salt, said macrocycle being chosen among phosphorylated crown-ethers in which the macrocycle comprises from 12 to 16 intracyclic atoms, at least one phosphorus atom, at least one oxygen atom and at least three additional heteroatoms selected in the group consisting of oxygen, sulphur and nitrogen. The invention also relates to the use of such a macrocycle for the selective trapping of lithium-7 isotope from a suspension of a solid lithium salt in a water non-miscible organic solvent.
The USA, as represented by the Secretary, Dept. of Health and Human Services (USA)
Pontificia Universidad Católica de Chile (Chile)
Inventor
Marugan, Juan J.
Ferrer, Marc
Southall, Noel T.
Dulcey, Andres E.
Hu, Xin
Dextras, Christopher R.
Talley, Daniel C.
Alvarez, Alejandra
Zanlungo, Silvana
Von Bernhardi, Rommy M.
Abstract
Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments.
C07D 243/38 - [b, e]- or [b, f]-condensed with six-membered rings
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
C07C 227/22 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reaction involving Beckmann rearrangement
C07C 319/14 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
A composite sliding block to be arranged between two supporting plates of a frictional-type seismic isolator, with one supporting plate connected to the superstructure to be isolated and the other to the foundations, comprising two contact components that externally are slidingly or articulatedly in contact with said supporting plates, depending on whether the isolator has one or two sliding surfaces, and internally are coupled to each other by means of a male projection of one component in a female recess of the other. An elastomeric seal occupies an empty space surrounding the projection within the recess and, on the external side of the contact component(s) slidingly in contact with the supporting plate(s), a sliding plate is accommodated in a corresponding niche having an elastomeric compression support at the bottom. Frictional pendulum-type isolators with one or two concave sliding surfaces include such a block.
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
In general, the present invention relates to the estimation of the length of patient hospitalisation by means of an estimation algorithm. In particular, the invention comprises electronic equipment for estimating the length of patient hospitalisation, which provides a quick estimation of said length of hospitalisation, information that is especially useful in outpatient or emergency care.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
32.
METHOD FOR SCALING GARMENT PATTERNS, WHICH MAKES IT POSSIBLE TO DEVISE SCALED GARMENTS WITH A FIT MATCHING THE BODY TYPE OF EACH USER
The present invention relates to a method for scaling garment patterns, which makes it possible to devise garments with a fit matching the body type of each user. The method comprises the following steps: a) measuring the human body according to differentiated bust, waist and hip sections, differentiated in turn into front and back sections, locating a number of markers; b) drawing a miniature pattern of the front and back of the garment and establishing a mathematical constant; c) determining, on the miniature pattern, a reference point for plotting polar coordinates; d) establishing strategic points on the outline of the miniature pattern; e) differentiating each strategic point by indexing them with the same special symbols adopted in step a); f) determining the value of the polar coordinates; and g) transferring the miniature pattern with the polar coordinates determined in step f) to full scale and on a definitive substrate, using a special flat scalimeter.
The present invention relates to the manufacture of aggregates from mine tailings, and to the use of said aggregates, pellets and/or fine aggregates in engineering applications as fillers, bases and sub-bases or in concrete mixtures.
The present invention relates to a nickel-based catalyst material useful in catalytic hydrogenation reactions, in addition to the method for manufacturing the catalyst. The present invention relates to a nickel-based catalyst material, supported on a silica-phyllosilicate matrix, wherein the material has a nanometric distribution of nickel particles on the surface of the silica-phyllosilicate matrix support.
The present invention discloses a cobalt-based catalyst material, useful in catalytic hydrogenation reactions, in addition to the method of producing the catalyst. The invention relates to a cobalt-based catalyst material, comprising a cobalt metal core and an external layer of silica that covers said core.
Disclosed is a fog collector (1), formed by a mesh-type capturing component (A) and a support component (B), which can reduce the gravitational loss of water, with facilitated transport in a folded or rolled state, the collector comprising a mesh panel (10) with a perimeter edge (101) attached, in a pre-stretched state, to a flexible perimeter frame formed by stabilising bands (12) and mounting bands (13). The stabilising bands (12) are made of a non-stretchable flexible laminar material and joined, by fusing and sewing means, to the perimeter edge (101) in the pre-stretched state, while the mounting bands (13) are formed by a body made of a non-stretchable flexible laminar material, folded lengthwise on itself along a longitudinal folding edge (131) and joined using fusing means along the length of each of the stabilising bands (12), wherein the material of the stabilising bands (12) and the mounting bands (13) has a modulus of elasticity lower than the modulus of elasticity of the material of the mesh panel (10).
B01D 45/06 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by utilising inertia by reversal of direction of flow
E03B 3/28 - Methods or installations for obtaining or collecting drinking water or tap water from humid air
37.
PORTABLE AND INTERACTIVE MAGNIFYING SYSTEM FOR ENLARGING IMAGES FROM AN ELECTRONIC MOBILE DEVICE
The invention relates to a portable and interactive magnifying system that allows the size of the display screen of an electronic mobile device to be increased, ensures an optimised light projection path within a confined space, provides a comfortable viewing angle for the user, allows the user to quickly access the electronic device while using the apparatus and allows for an interaction with the user so that the apparatus is used as a graphic support for drawing, writing and other similar activities. It comprises an optical module formed by at least one reflection element, at least one optical lens and a projection screen onto which the enlarged image from the electronic device is projected; an interactive module comprising a digital pen that emits infrared light onto said projection screen, a micro camera that captures the infrared light path of the digital pen from an inner face of said projection screen and comprises communication means between said micro camera and the electronic device of the user; said components of the optical module and the micro camera of the interactive module being positioned in a fixed manner in an optimal projection location and arranged in a foldable portable casing, configured to change between an upright position creating a volume with an inner cavity in which the position and orientation of the components of the optical module and of the micro camera are determined, and a collapsed position to reduce the volume thereof and facilitate the portability thereof.
G06F 3/00 - Input arrangements for transferring data to be processed into a form capable of being handled by the computerOutput arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
G06F 3/042 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means by opto-electronic means
H04M 1/02 - Constructional features of telephone sets
38.
ANTENNA CALIBRATION BY MEANS OF AUTONOMOUS FLYING VEHICLES
The present invention relates to the calibration of antennas by means of autonomous or unmanned aircraft vehicles (UAVs) also known as drones. In particular, the invention discloses a system and a method to calibrate antennas by means of a UAV which is remotely positioned, carrying a known signal transmitting source or signal transmitter, wherein the transmitted signals are received by the antenna or receptor and used in their calibration. The system and method of the invention can be used with various types of antennas that receive or capture signals, for example, with the radio telescopes used in astronomy studies.
The present invention relates to a method of operation and autonomous robotic system for remotely collecting products in stores. The system includes a mobile robot (1), and navigation, product recognition and multi-objective planning systems. The mobile robot (1) comprises vision sensors to obtain image and distance information, a mobile base (2), and an actuator (3) or robotic arm arranged on the mobile base and which can perform movements in height, depth and rotation to handle and move products from store shelves to a temporary storage area (4). Said actuator (3) comprises an end effector (34) with at least two suction cups of different sizes and having rotational and tilting movements about a vertical axis. The product recognition system comprises identification algorithms configured to recognise, based on the vision information, object shapes corresponding to an external shape, and to read logos or texts on the products to identify the products, obtaining location and distance information about the identified products. The main objective of the invention is to provide a mobile robot capable of collecting and handling items or products of different shapes and sizes, without requiring operator intervention or replacement of the tools used.
A prosthetic device can be implanted in the corpora cavernosa of a penis with erectile dysfunction. The device being formed by two cylinders that can be inflated with a fluid. The device comprises a variable-length erectable portion formed by a chamber that can be pressurized with a low volume of fluid and is formed between an expandable membrane and an axially extendable and foldable longitudinal rib. The membrane and rib extend between a distal tip element and an intermediate connector from which a shortenable anchoring rod emerges, the rib being a single piece formed by a variable-length distal section, an intermediate section that is foldable and extendable in an axial direction, and a proximal section comprising optimized means for the continuous lateral supply of the fluid to the pressurisable chamber. The device also has an integrated unit for storing and pressurizing the fluid, which can be implanted in the scrotum.
The invention relates to the novel use of an immunogenic formulation containing the bacillus Calmette-Guérin (BCG) strain at a concentration between 104-109 bacteria, expressing at least one protein or immunogenic fragment of respiratory syncytial virus (RSV, Human orthopneumovirus), in a pharmaceutically acceptable saline buffer solution because it serves to prepare a vaccine useful to prevent, treat, or attenuate human metapneumovirus (hMPV) infections.
Agarophyton chilensis extract, enriched with free fatty acids and PPARγ modulators, comprising palmitic acid, stearic acid, myristic acid, oleic acid, and 8-hydroxyeicosatetraenoic acid (8-HETE). Method for obtaining the extract. Nutraceutical composition, comprising the extract enriched with free fatty acids and PPARγ modulators, wherein said extract is useful for treating or preventing health problems, which require neuroprotection, wherein said neuroprotection involves activation of PPARγ receptors.
A61K 36/04 - Rhodophycota or rhodophyta (red algae), e.g. Porphyra
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
43.
ANTIVIRAL COMPOSITION BASED ON EXTRACTS OF DURVILLAEA ANTARCTICA USEFUL FOR TREATING LESIONS CAUSED BY ALPHAHERPESVIRINAE VIRUS
Composition with antiviral activity comprising water-soluble extracts of Durvillaea antarctica substantially free of alginates and a carrier or vehicle, and the method of obtaining it. Where this composition serves to prepare an antiviral drug of topical application, to prevent or treat skin or oral lesions caused by herpes viruses of the subfamily Alphahehrpesvirinae, such as herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and varicella zoster virus (VZV), resistant or not to acyclovir (ACV).
The present invention is intended for the food sector, specifically the field of bioactive compounds obtained from food products, and relates to the provision of a new method for producing peptides with anti-hypertensive activity, comprising treating whey from cow's milk with plant proteases. The present invention also relates to a product containing the bioactive peptides and to the uses of said product to formulate foods that allow blood pressure to be maintained at acceptable levels in order to reduce the risk of suffering from diseases related to high blood pressure.
A23J 3/34 - Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
The present invention relates to the use of a combination of estretol (E4) and progesterone (P4) to prepare a medicine that is useful in the treatment of endometriosis. The medicine of the invention does not lower progesterone-receptor (PR) levels, but it does increase progesterone-receptor levels in endometrial cells, causing the disease to progress more slowly and preventing the development of resistance to treatment.
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61P 15/00 - Drugs for genital or sexual disordersContraceptives
46.
CONJUGATES BETWEEN A BIOPOLYMER AND A PHOTOACTIVATED ANTIMICROBIAL AGENT FOR COMBATING FUNGAL DISEASES OF AGRICULTURAL INTEREST AND METHODS FOR PRODUCING SAID CONJUGATES
This invention relates to the field of control of different fungal diseases in the agricultural industry. Specifically, the invention reports conjugates between biopolymers and a photoactivable agent, which when activated by light generates singlet oxygen, a species known for its antimicrobial capacity. The invention also relates to methods of production of these conjugates and their uses.
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Device for training and direct practice of breast self-palpation techniques for the early detection of breast cancer comprising a container flexible body refillable with viscous fluid, a support and transfer platform connected to the body, means to simulate the type of abnormal tissue detectable within the body; fluid distributor element directly on the user's skin coming from the chamber and transfer means arranged towards the distributor element.
A hybrid shear wall system for construction of massive timber buildings of more than two stories in seismic zones, is provided, which presents a ductile behavior and reduced overturning effect against a lateral load caused by destructive natural events, such as earthquakes or strong winds; the shear wall system comprises an interior frame with articulated nodes of union between columns and sills, to which exterior massive timber panels are joined on both opposite faces, by means of individual energy dissipating connectors; where the frame comprises post-tensioned self-centering means, which together with the articulated nodes, the exterior massive timber panels and the connectors, act together as a unit and allow the shear wall to behave in a ductile manner and with reduced overturning effect under high lateral load.
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
E04C 2/12 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of wood, fibres, chips, vegetable stems, or the likeBuilding elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of plasticsBuilding elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of foamed products of solid wood
49.
ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
PONTIFICIA UNIVERSIDAD DE CATÓLICA DE CHILE (Chile)
Inventor
Ocaranza Geraldino, María Paz
Kogan, Marcelo Javier
Lavandero González, Sergio Alejandro
Chiong Lay, Mario Martín
Abstract
The present invention provides an angiotensin-(1-9) analog, particularly an angiotensin-(1-9) peptide synthesized from D-amino acids. This invention further involves the inversion of the original sequence of angiotensin-(1-9). This analog possesses an increased stability and maintains the biological activity of angiotensin-(1-9). Another embodiment of this invention comprises pharmaceutical compositions containing said analog and their use in the treatment of cardiovascular diseases, tissue remodeling in kidney, brain, and also the induction of cardioprotection.
The invention relates to a multi-port power converter and to a power conversion system that implements the power converter of the invention in order to connect at least two direct current (DC) elements with at least one alternating current (AC) element by using a single simultaneous conversion step. Furthermore, the invention relates to the use of the power conversion system.
Disclosed is a window system (1) for installation in a building, which improves energy efficiency, thermal comfort and visual comfort in the inside environment where the window system (1) is mounted. The window system comprises: double glazing formed by a first glass pane and a second glass pane arranged parallel and separated a certain distance by means of a spacer (4), such that there is a cavity therebetween; a frame (5) in which the glass panes and the spacer (4) are mounted, allowing their installation in the building, wherein the glass panes are fixed by means of a seal (6). The cavity comprises a phase-change material (8) at least partially filling the cavity such that the cavity has an air space at the top capable of resisting the expansion of the material (8) as a result of the phase change, wherein the phase-change temperature of the phase-change material (8) is such that at low temperatures, the phase change material (8) is in solid state, while when the temperature and radiation incident on the window increase, the phase change material (8) changes to liquid state, absorbing energy; and an interior seal (7) on the bottom edge and the lateral edges of the cavity, wherein the interior seal (7) prevents the phase-change material from leaking and allows increased strength of the seal between the glass panes and the spacer (4), preventing potential damage to the seals that fix the glass panes and to other elements of the window system (1) caused by the use of the phase-change material (8). According to the invention, the frame (5) comprises at least two openings (9) at the top, allowing the interior seal (7) to be added during the assembly of the window system (1) and the cavity to be filled with the phase-change material (8) ins liquid state.
E06B 3/66 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges
E06B 3/67 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges characterised by additional arrangements or devices for heat or sound insulation
F28D 20/02 - Heat storage plants or apparatus in generalRegenerative heat-exchange apparatus not covered by groups or using latent heat
52.
IMMUNOGENIC FORMULATION CONTAINING ONE OR MORE MODIFIED BCG STRAINS EXPRESSING A SARS-COV-2 PROTEIN, USEFUL FOR PREVENTING, TREATING OR ATTENUATING THE DEVELOPMENT OF COVID-19.
The invention relates to an immunogenic formulation containing one or more modified recombinant Bacillus Calmette-Guerin (BCG) strains at a concentration between 104-109 bacteria, wherein each BCG strain expresses at least one protein or immunogenic fragment of SARS-CoV-2, in a pharmaceutically acceptable saline buffer solution, wherein this formulation serves to prepare vaccines useful for preventing, treating or attenuating SARS-CoV-2 infections.
C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
53.
IN-VITRO METHOD FOR DIAGNOSING AND PREDICTING THE AGGRESSIVENESS OF THYROID CANCER, AND THE PRECISION SURGERY OPTIONS AND TYPE TO BE USED TO REMOVE A TUMOUR FROM A PATIENT; KIT; REAGENTS FORMING THE KIT; AND USE OF THE REAGENTS AND USE OF MOLECULAR MARKERS AS PART OF THE METHOD
Disclosed is an in-vitro method and a kit for diagnosing and predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove a tumour from a patient. The scope of the invention includes reagents forming the kit and the use of the reagents as part of the kit. Also provided is the use of markers for predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove the tumour from a patient.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
54.
DEVICE FOR STERILISING OBJECTS BY APPLYING UV-C LIGHT IRRADIATION
Disclosed is a sterilising device (1) for sterilising objects by applying UV-C light irradiation and a flow of ozone, capable of optimising sterilisation by reducing the time of exposure of several objects at the same time, and ensuring that the entire surface receives the minimum dose necessary for sterilisation, with purification of the residual air on completion of each cycle; the device comprises a multiple sterilising radiation source (20) having at least one first UV-C light-emitting tube (21) and at least one second UV-C light-emitting tube (22), parallel to each other; the multiple radiation source (20) is installed on a mobile component (30) that is displaced linearly relative to a static component (40) comprising at least one support (41) for the positioning of the objects to be treated, this being transparent to UV-C irradiation and permeable to ozone flows, comprising a first irradiable side (42) facing a second irradiable side (43); where the mobile component (30) simultaneously displaces the UV-C light-emitting tubes, maintaining said first tube (21) at a first distance (d1) relative to the aforementioned first irradiable side (42) of the support (41), and said second tube (22) at a second distance (d2) relative to the aforementioned second irradiable side (43) of the same support (41).
DERIVATIVES OF ADAMANTYL OXADIAZOLES AND PHARMACEUTICALLY ACCEPTABLE SOLVATES, HYDRATES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SAME, SYNTHESIS METHOD, SUITABLE FOR USE AS EFFECTIVE AND SELECTIVE INHIBITORS OF THE REDUCTASE ACTIVITY OF THE ENZYME 11-BETA DEHYDROGENASE TYPE 1 (11B-HSD1)
The present invention relates to compounds derived from adamantyl oxadiazoles and the pharmaceutically acceptable solvates, hydrates and salts of same. These compounds are suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1), as well as in the production of a drug for treating conditions and diseases such as high blood pressure, obesity, dyslipidaemia, type 2 diabetes, insulin resistance, glaucoma, metabolic syndrome, cognitive disorders, osteoporosis, immune disorders, depression and other conditions. Also provided is a pharmaceutical composition comprising the compounds and a method for preparing said composition.
C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
56.
Monoclonal antibodies specific for the PB2 antigen of the human influenza A virus (flu), nucleotide sequences, method and diagnostic kit for flu infection
Generation of monoclonal antibodies, or fragments thereof, that recognize the PB2 protein of the human influenza A virus (Flu), where the monoclonal antibodies or fragments thereof, has a heavy chain variable region and light chain variable region. Furthermore, a diagnostic method is provided to detect Flu infections in biological samples of nasopharyngeal secretions, using monoclonal antibodies in diagnostic kit format.
Disclosed is an individual protection device for forest species, which is placed around a plant under cultivation to provide it with protection and a favourable growth environment. The device is able to provide long-lasting and secure protection with a structure of completely biodegradable material and is formed by: a vertical hollow one-piece body with an open upper end and an open opposite lower end, an internal cavity being defined therebetween, the perimeter of said cavity being cylindrically defined by a curved wall; and closure means that secure the curved plate in its cylindrical position.
A01G 13/10 - Devices for affording protection against animals, birds or other pests
A01G 9/02 - Receptacles, e.g. flower-pots or boxes Glasses for cultivating flowers
A01M 29/30 - Scaring or repelling devices, e.g. bird-scaring apparatus preventing or obstructing access or passage, e.g. by means of barriers, spikes, cords, obstacles or sprinkled water
58.
IMMUNOGENIC FORMULATION CONTAINING A MODIFIED BCG STRAIN EXPRESSING AN ANDESVIRUS (ANDV) PROTEIN USEFUL FOR PREVENTING AND TREATING HANTA-AND VIRUS INFECTIONS
The invention relates to an immunogenic formulation containing the Bacillus Calmette-Guérin (BCG) strain at a concentration between 104-109 bacteria, expressing at least one protein or immunogenic fragment of Andesvirus (ANDV), in a pharmaceutically acceptable saline buffer solution that serves to prepare a vaccine useful for preventing, treating or attenuating ANDV infections. ANDV belongs to the Hantavirus family and is a highly virulent human pathogen, which annually affects dozens of people in Chile, causing Hantavirus Cardiopulmonary Syndrome (HCPS) in some infected people.
Disclosed is a modular system for manufacturing garments, from an unlimited number of modular pieces having different sizes and styles and which can be combined together immediately and temporarily, wherein the designed garment can be worn (put on or removed) without needing to separate the pieces. The system comprises a set of modular pieces (10, 20) having different sizes and styles and which are made of elasticated fabric, the pieces comprising a respective joining edge (11, 21) for coupling together by means of a perimeter joining interface (30) formed by a transverse coupling portion (31) and a longitudinal adjusting portion (32), wherein the coupling portion (31) comprises an elasticated closure (33) that temporarily joins the modular pieces, whereas the adjusting portion (32) does not comprise the elasticated closure and has greater stretchability than that of the coupling portion (31).
Monoclonal antibody or antigen binding fragment thereof that binds to the L protein of the human parainfluenza virus (PIV); method and kit for detecting PIV
Generation of monoclonal antibodies, or fragments thereof, that recognize the human parainfluenza virus (human PIV) chimeric protein L, where the monoclonal antibodies or fragments thereof have a heavy chain variable region and a light chain variable region. In addition, a method of diagnosing human PIV infection in a biological sample of nasopharyngeal secretion is provided, using the monoclonal antibodies in diagnostic kit format.
The invention relates to a biochemical diagnostic test performed on peripheral blood, which allows the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD). Specifically, the serum levels of at least 6 markers corresponding to 2 groups of functional lipids, esfingolipids and long-chain polyunsaturated fatty acids (LC-PUFAs) are measured, specifically: Ceramide C16:0, Ceramide C24:0, Deoxy dihydro-ceramide C24:1 and Sphinganin 1-phosphate, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), detecting a variation in concentrations with respect to the values for the control population.
The invention relates to a method for rapidly detecting olfactory disfunction, and to a kit comprising the means necessary to apply it. The method or test allows individuals suspected of being asymptomatic, pre-symptomatic or symptomatic carriers of the SARS-CoV-2 virus to be identified by means of the early detection of acute change in the sense of smell (anosmia/hyposmia), which is a highly prevalent and discriminant symptom of COVID-19. The test is validated using a prospective study, allowing its intrinsic properties – sensitivity, specificity, accuracy, precision and cut-off, among others – to be defined on the basis of the identification of odours.
Device (1) for preventing apnea episodes in infants, which simulates a breathing pattern suitable for synchronizing the infant's breathing and which is provided as a tactile direct stimulus, arranged in contact with the infant's back while sleeping; it comprises a breathing pattern generator means (2) that emits air pulses that reach the infant through transmitter means comprising a flexible conduit (3) that transports the air to an inflatable/deflatable chamber (4).
A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
64.
METHOD FOR PREPARING NANOCELLULOSE USING SPECIALLY SYNTHESISED "GREEN" SOLVENTS
The present invention relates to a method for preparing nanocellulose, which comprises hydrolysing cellulose using a solvent comprising a dihydrogen phosphate anion, wherein the solvent is selected from an ionic liquid (LI) and a deep eutectic solvent (DES). The invention also relates to specially synthesised "green solvents" and to their use.
The purpose of the proposed invention is to solve the unresolved problem of having techniques for separating a water current containing different components, depending on their origin. This separation results in two currents, one with the water with a reduced content of the components to be separated, and another current with the enriched component present in the water. In the mentioned separation problem, depending on the initial current and the end goal, it is possible to recover the water current or the current with the component.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
66.
METHOD FOR PREPARING CSPBBR3 PEROVSKITE FILMS USING CHEMICAL VAPOUR DEPOSITION
The present invention relates to a method for preparing films of perovskite having structure CsPbBr3, which comprises the use of chemical vapour deposition (CVD) using previously synthesised CsPbBr3 crystals as precursor material.
C23C 16/00 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
The invention relates to a non-invasive method for detecting gastric cancer based on the detection of a new molecular marker in blood. In particular, via the detection of the long non-coding RNA (LncRNA) KCNQ1OT1 in peripheral blood, wherein an increase in the expression of this LncRNA correlates with gastric cancer or the precursor lesions thereof (OLGA stage III and IV).
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A composite sliding block for the disposition thereof between two supporting plates of a frictional-type seismic isolator, with one supporting plate connected to the superstructure to be isolated and the other to the foundations, comprising two contact components that externally are slidingly or articulatedly in contact with said supporting plates, depending on whether the isolator has one or two sliding surfaces, and internally are attached to each other by means of a male projection of one component in a female recess of the other. An elastomeric seal occupies an empty space surrounding the projection within the recess and, on the external side of the contact component(s) slidingly in contact with the supporting plate(s), a sliding plate is accommodated in a corresponding niche with an elastomeric compression support at the base. A number of frictional, pendulum-type isolators with one or two concave sliding surfaces are included in said block.
E04B 1/00 - Constructions in generalStructures which are not restricted either to walls, e.g. partitions, or floors or ceilings or roofs
E04B 1/92 - Protection against other undesired influences or dangers
E04B 1/98 - Protection against other undesired influences or dangers against vibrations or shocksProtection against other undesired influences or dangers against mechanical destruction, e.g. by air-raids
E04H 9/00 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
69.
Specific monoclonal antibody against the N antigen of human respiratory syncytial virus (hRSV) useful for treating infection, detection thereof and diagnosis
The invention relates to a monoclonal antibody or fragment thereof, which recognizes the N (nucleocapsid) protein of the human respiratory syncytial virus (RSV), useful for the development of diagnostic methods for RSV infection and for the production of pharmaceutical compositions intended for the treatment, protection and/or prophylaxis of RSV infection.
The present invention refers to a new monoclonal antibody or fragment thereof, called 14F5F6, which specifically recognizes herpes simplex virus (HSV), in its two types, herpes simplex virus type 1 and herpes simplex virus type 2 (HSV-1 and HSV-2). Preferably, the antibody of the invention is useful for the development of methods for the diagnosis of herpes simplex virus infection, as well as for the production of pharmaceutical compositions intended for the treatment, protection and/or prophylaxis of infection specifically caused by HSV-1 and HSV-2.
The present invention refers to a new monoclonal antibody or fragment thereof, called 11B2C7, which specifically recognizes herpes simplex virus (HSV), in its two types, herpes simplex virus type 1 and herpes simplex virus type 2 (HSV-1 and HSV-2). Preferably, the antibody of the invention is useful for the development of methods for the diagnosis of herpes simplex virus infection, as well as for the production of pharmaceutical compositions intended for the treatment, protection and/or prophylaxis of infection specifically caused by HSV-1 and HSV-2.
Disclosed is a prosthetic device (1) that can be implanted in the corpora cavernosa of a penis with erectile dysfunction, and the production method thereof, the device being formed by two cylinders that can be inflated with a fluid. The device can be implanted in a wide range of patients according to penis length and optimises the use of a low volume of the fluid to achieve a functional erection. The device comprises a variable-length erectable portion (10) formed by a chamber (100) that can be pressurised with a low volume of fluid and which is formed between an expandable membrane (300) and an axially extendable and foldable longitudinal rib (200). The membrane (300) and the rib (200) extend between a distal tip element (400) and an intermediate connector (500) from which a shortenable anchoring rod (600) emerges, the rib (200) being a single piece formed by a variable-length distal section (206), an intermediate section (205) that is foldable and extendable in an axial direction, and a proximal section (204) comprising optimised means for the continuous lateral supply of the fluid to the pressurisable chamber (100). The device (1) also has an integrated unit (700) for storing and pressurising the fluid, which can be implanted in the scrotum.
B29C 41/00 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor
B29C 41/02 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of definite length, i.e. discrete articles
73.
IMPLANTABLE PROSTHETIC DEVICE TO GENERATE PENILE ERECTION IN MEN WITH ERECTILE DYSFUNCTION AND ITS PRODUCTION PROCEDURE
Disclosed is a prosthetic device (1) that can be implanted in the corpora cavernosa of a penis with erectile dysfunction, and the production method thereof, the device being formed by two cylinders that can be inflated with a fluid. The device can be implanted in a wide range of patients according to penis length and optimises the use of a low volume of the fluid to achieve a functional erection. The device comprises a variable-length erectable portion (10) formed by a chamber (100) that can be pressurised with a low volume of fluid and which is formed between an expandable membrane (300) and an axially extendable and foldable longitudinal rib (200). The membrane (300) and the rib (200) extend between a distal tip element (400) and an intermediate connector (500) from which a shortenable anchoring rod (600) emerges, the rib (200) being a single piece formed by a variable-length distal section (206), an intermediate section (205) that is foldable and extendable in an axial direction, and a proximal section (204) comprising optimised means for the continuous lateral supply of the fluid to the pressurisable chamber (100). The device (1) also has an integrated unit (700) for storing and pressurising the fluid, which can be implanted in the scrotum.
B29C 41/00 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor
B29C 41/02 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor for making articles of definite length, i.e. discrete articles
74.
NOVEL USE OF BCG IMMUNOGENIC FORMULATION EXPRESSING A HUMAN RESPIRATORY SYNCYTIAL VIRUS PROTEIN AGAINST HMPV IN CATTLE
The invention relates to the novel use of an immunogenic formulation containing the bacillus Calmette-Guérin (BCG) strain at a concentration between 104-109, which recombinantly expresses at least one protein or immunogenic fragment of human respiratory syncytial virus (RSV, Human orthopneumovirus), stabilised in a pharmaceutically acceptable saline buffer solution to prevent, treat or mitigate hMPV infections in cattle.
The invention relates to the novel use of an immunogenic formulation containing Bacillus Calmette-Guerin (BCG) in a concentration between 104 -109 bacteria, which recombinantly expresses at least one protein or immunogenic fragment of the human Respiratory Syncytial Virus (hRSV, human orthopneumovirus), stabilized in a pharmaceutically acceptable saline buffer solution to prevent, treat, or attenuate bRSV infections in cattle.
Disclosed is a system and method for controlling and managing energy demand in electrical systems, comprising exchanging information, and coordinating and controlling demand distributed according to signals delivered by a demand aggregation unit to each participant of the system. Demand aggregation includes information exchange regarding the flexibility of clients and the electrical system, which is represented by a demand trajectory band using the bandwidth of demand delivered to the client.
H02J 4/00 - Circuit arrangements for mains or distribution networks not specified as ac or dc
H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the networkCircuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
77.
Non-invasive detection of gastric cancer by detecting the methylation of Reprimo-like in the blood
The invention aims at a non-invasive method of early diagnosis of gastric cancer, using as a biomarker the levels of methylation of the DNA sequence of the promoter of the Reprimo-like gene in plasma. The inventors have established the utility of Reprimo-like as a biomarker, and especially as a biomarker for the early detection of gastric cancer, since they have determined that Reprimo-like is consistently silenced in gastric cancer, both in incipient and advanced stages. This silencing is given by methylation of its promoter region, which is detectable in plasma samples, allowing us to measure it as a liquid biopsy in a non-invasive, fast and inexpensive way.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
78.
MACROCYSTIS PYRIFERA, USEFUL FOR TREATING LESIONS CAUSED BY ALPHAHERPESVIRINAE VIRUSES
A composition with antiviral activity which comprises water-soluble extracts of Macrocystis pyrifera substantially alginate-free and a carrier or vehicle, and method for obtaining same. Wherein this composition serves to prepare a topical antiviral medicinal product for preventing or treating skin or oral lesions caused by herpes viruses of the subfamily Alphahehrpesvirinae, such as herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and varicella zoster virus (VZV), resistant or non-resistant to acyclovir (ACV).
Disclosed are a composition with antiviral activity comprising substantially alginate-free water-soluble extracts of Durvillaea antarctica and a carrier or vehicle, and a method for producing same. The composition is used to prepare a topical antiviral drug, for preventing or treating oral or skin lesions cause by herpes viruses of the subfamily Alphahehrpesvirinae, such as herpes simplex virus 1 (HSV-1), herpes simplex virus 2 (HSV-2) and varicella zoster virus (VZV), resistant or non-resistant to aciclovir (ACV).
The invention relates to the novel use of an immunogenic formulation containing the bacillus Calmette-Guérin (BCG) strain at a concentration between 104-109 bacteria, expressing at least one protein or immunogenic fragment of respiratory syncytial virus (RSV, Human orthopneumovirus), in a pharmaceutically acceptable saline buffer solution because it serves to prepare a vaccine useful to prevent, treat, or attenuate human metapneumovirus (hMPV) infections.
PHOTOCATALYTIC SYSTEMS COMPRISING CYCLODEXTRIN, C8-C12 CARBOXYLIC ACID AND NANOPARTICLES OF METAL AND/OR OF METAL OXIDES; PREPARATION METHOD THEREOF; AND USE OF THE SYSTEMS TO REMEDIATE POLLUTED WATER
81222222 and of Ag are stabilised by the complex formed by α-cyclodextrin/nonanoic acid/mercaptoacetic acid. The invention also relates to methods for preparing the photocatalytic systems, and to the use of same to remediate polluted water.
B01J 31/38 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of titanium, zirconium or hafnium
B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
C02F 1/00 - Treatment of water, waste water, or sewage
C02F 1/72 - Treatment of water, waste water, or sewage by oxidation
C02F 3/00 - Biological treatment of water, waste water, or sewage
82.
DEVICE FOR THE REPAIR OF CRACKS IN ASPHALT ROAD SURFACES BY MEANS OF MICROWAVES WHICH INCREASE THE TEMPERATURE OF THE ASPHALT FORM THE SURFACE DOWNWARDS, BRINGING ABOUT THE SELF-REPAIR OF THE MATERIAL WITH MINIMAL INTERVENTION
A machine which seals and repairs cracks or fissures in asphalt road surfaces by means of microwaves, enabling a uniform increase in temperature of the asphalt, in such a way that a self-repair of the asphalt is produced with minimal intervention, comprising a supporting structure whereon the elements of the machine and a drive mechanism are installed, comprising: a plurality of microwave generators; a number of waveguides that direct the microwaves toward the surface; a plurality of resonance chambers installed below the microwave generators, comprising a wave diffuser in their interior, enhancing the reflection of the waves; a consumable part between the resonance chambers and the surface which confines the microwaves within said part; a motor that propels the drive mechanism; at least one frontal sensor and at least one rearward sensor which measure the temperature of the asphalt; a water spraying system that injects water into the surface and increases the humidity; a cooling system that controls the operating temperature; a speed control unit which is connected to the motor and to the sensors; a general control unit connected to the sensors, to the microwave generators, to the water spraying system and to the cooling system, and which manages the operation of the machine; where the speed control unit and the general control unit receive information from the sensors to regulate the speed and to determine the activation and deactivation of the microwave generators.
E01C 7/06 - Coherent pavings made in situ made of road-metal without binders by melting, burning, or vitrifying road-metal in situ
E01C 19/08 - Apparatus for transporting and melting asphalt, bitumen, tar, or the like
E01C 23/03 - Arrangements for curing pavingDevices for applying curing meansDevices for laying prefabricated underlay, e.g. sheets, membranesProtecting paving under construction or while curing, e.g. use of tents
E01C 23/14 - Auxiliary devices or arrangements for constructing, repairing, reconditioning, or taking-up road or like surfaces for heating or drying foundation, paving, or materials thereon, e.g. paint
83.
METHOD FOR GENERATING ALLERGEN-SPECIFIC TOLEROGENIC CELLS, TOLEROGENIC CELLS OBTAINED, AND METHODS FOR INDUCING ALLERGEN TOLERANCE BY MEANS OF AUTOLOGOUS IMMUNOTHERAPY
The present invention relates to methods for treating different allergic diseases. More specifically, a method is disclosed for generating allergen-specific tolerogenic cells for use as an autologous immunotherapy in allergic diseases. Also described are the allergen-specific tolerogenic cells obtained and methods for inducing allergen tolerance by means of autologous immunotherapy.
A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
The invention relates to a device for training and direct practice of breast self-palpation techniques for early detection of breast cancer, which comprises a flexible container body that can be refilled with viscous fluid, a support and transfer platform connected to the body, means for simulating abnormal tissue type that can be detected inside the body; an element for dispensing fluid directly onto the user's skin, coming from the chamber and transfer means arranged towards the dispensing element.
The invention relates to a disposable absorbent garment for male incontinence in active adults, comprising a multilayer absorbent component located between front and rear supports with adjustable-length side fastening bands, having a reversible container element for self-packing; and the absorbent component has a perimeter contour with rounded rear edge, a substantially straight opposite front edge, wider than the rear edge, and a U-shaped upper projection.
A61F 13/471 - Sanitary towels, incontinence pads or napkins specially adapted for male use
A61F 13/49 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the shape specially adapted to be worn around the waist, e.g. diapers, nappies
A61F 13/496 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators characterised by the shape specially adapted to be worn around the waist, e.g. diapers, nappies in the form of pants or briefs
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
86.
SYSTEM AND METHOD FOR MONITORING EVAPORATION ON A LARGE SCALE
The invention relates to a system and method for monitoring evaporation on a large scale, especially from surfaces of 100-500 m2, the system comprising: an optical instrument formed by an emitter device (100) and a receiver device (200), which are separated by a surface (300) to be monitored and are installed on a frame; a weather station (400); and a data gathering, processing and storage device, wherein the emitter device of the optical instrument comprises a laser instrument coupled to a collimator telescope, and the receiver device comprises two high-speed cameras (14), the frame of the emitter device (100) and of the receiver device (200) comprising a mechanism for automatically adjusting the azimuth and elevation angles, which is configured to keep said devices aligned with a common optical axis.
G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
87.
CONJUGATES BETWEEN A BIOPOLYMER AND A PHOTOACTIVATED ANTIMICROBIAL AGENT FOR COMBATING FUNGAL DISEASES OF AGRICULTURAL INTEREST AND METHODS FOR PRODUCING SAID CONJUGATES
The present invention relates to the field of fungal disease control in the agricultural industry. The invention specifically discloses conjugates between biopolymers and a photoactivated agent which, upon being activated by light, give rise to singlet oxygen, a species known for its antimicrobial capacity. The invention also relates to methods for producing these conjugates and uses thereof.
A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
A01N 43/90 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
The invention relates to a pedestrian crossing device for traffic lights, which comprises: a base covered by a front cover; a push button; a wireless sensor; and an electronic apparatus disposed between the base and the front cover, the electronic apparatus being in connection with the push button and the wireless sensor and comprising at least one printed circuit board, a microprocessor and a wireless communication module. The invention also relates to a pedestrian crossing system for traffic lights and to a method for managing the system.
SYSTEM AND METHOD FOR DETERMINING AND QUANTIFYING THE CONCENTRATION OF AN ANALYTE, WHICH COMPRISES AN OPTICALLY ACTIVE DIAMOND-BASED SENSOR, A CHAMBER ACCOMMODATING THE SENSOR, AND MEANS FOR INSERTING A SAMPLE; AND USE OF SAID SENSOR
The present invention relates to a system for determining and quantifying the concentration of an analyte in a sample, which comprises: a diamond-based sensor containing optically active colour centres close to the surface; a chamber or cell accommodating the diamond; and means for inserting the sample into the system. The invention also relates to a method for measuring an analyte in a sample containing same, which is carried out in the developed system; and to the use of the sensor.
An Agarophyton chilensis extract, enriched with free fatty acids and PPARγ modulators, which comprises palmitic acid, stearic acid, myristic acid, oleic acid and 8-hydroxyeicosatetraenoic acid (8-HETE). A method for obtaining the extract. A nutraceutical composition which comprises the extract enriched with free fatty acids and PPARγ modulators, wherein said extract is suitable for treating or preventing health conditions that require neuroprotection, said neuroprotection involving the activation of PPARγ receptors.
A61K 36/04 - Rhodophycota or rhodophyta (red algae), e.g. Porphyra
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
91.
HYBRID SHEAR-WALL SYSTEM FOR THE CONSTRUCTION OF SOLID-WOOD BUILDINGS IN SEISMIC ZONES
The invention relates to a hybrid shear-wall system for the construction of solid-wood buildings having more than two floors, in seismic zones, which has ductile behaviour and reduced toppling effect against a lateral load caused by natural destructive events, such as earthquakes or strong winds. The shear-wall system comprises an interior frame with articulated nodes for connecting between columns and beams, exterior solid-wood panels being connected to the frame on both opposite faces by means of individual energy-dissipating connectors, wherein the frame comprises post-tensioned self-centring means, which, together with the articulated nodes, the exterior solid-wood panels and the connectors, act jointly as a unit and allow the shear wall to behave in a ductile manner and with reduced toppling effect against a high lateral load.
Techniques for quantifying respiration using a wearable device are described. According to some aspects, a wearable device includes multiple thermal sensors thermally coupled to one or more heat spreaders. The wearable device may in some cases be small enough to be wearable between the mouth and nose of the patient, such as via an adhesive attachment to the upper lip. When the patient exhales, air is produced through the mouth and/or through the nose. Each heat spreader may absorb heat of exhaled air which may thermally propagate to a thermal sensor coupled to the heat spreader. By measuring the change in temperature over time measured by the thermal sensors, measures of respiration such as respiratory rate, minute volume and/or tidal volume of the patient may be determined. Such measures may be determined by the wearable device or by an external device to which data is transmitted.
The United States of America, as represented by the Secretary, Department of Health and Human Services (USA)
Pontificia Universidad Catolica de Chile (Chile)
Inventor
Marugan, Juan J.
Ferrer, Marc
Southall, Noel T.
Dulcey, Andres E.
Hu, Xin
Dextras, Christopher R.
Talley, Daniel C.
Alvarez, Alejandra
Zanlungo, Silvana
Von Bernhardi, Rommy M.
Abstract
Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments.
A61K 31/553 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 243/38 - [b, e]- or [b, f]-condensed with six-membered rings
A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
C07C 227/22 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reaction involving Beckmann rearrangement
C07C 319/14 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
The present invention is a composition that can form an edible film or an edible liquid coating that can be applied to the surface of fresh fish (fillets or cuts) or fresh seafood. The present invention acts as a physical barrier preventing oxygen, water and microorganisms from entering the food product, and also acts as a bacteriostatic and antioxidant agent.
LAPAROSCOPIC SURGERY SIMULATOR DEVICE AND SYSTEM FOR THE PERFORMANCE OF A PLANNED ADVANCED TRAINING PROCEDURE, WITH REMOTE AND DEFERRED INTEGRAL ASSESSMENT OF LAPAROSCOPIC SURGICAL SKILLS; AND ASSOCIATED PROCEDURE
A simulator device for the advanced training of laparoscopic skills, enabling the simulation of the real conditions of a surgical intervention; the laparoscopic surgery simulation system for the performance of a planned advanced training procedure, with remote and deferred integral assessment of the laparoscopic surgical skills; and said procedure. According to the invention, the simulator device comprises: a) a portable casing; b) a central control module; c) an automated means of raising and tilting the casing; d) a means for the internal capture of high-resolution video; e) a robotic means for holding the video image capture means; f) an external means for the capture of images; g) a user interface means; h) internal illumination means; i) storage means; j) electronic connection means; k) a wireless connection module for the operation and remote supervision of the device, connected to the central control module. The simulator system comprises a) a simulator device that enables the simulation of the real conditions of a surgical intervention and captures video images of both the training activity inside the device and external activity related to ergonomics and movements of the user; b) a biometric multi-sensor module; c) a remote module for the assessment of the training; and d) an administrator module for the processing of the captured data, which integrates the data collected from the simulator device and the biometric multi-sensor module, processes said data and sends same in the form of a data packet to the remote training assessment module. The procedure comprises the steps of: i) obtaining data from video images and biometric data from the user; ii) generating a data packet; iii) sending the generated data packet to a remote mass storage module; iv) assessing the data packet sent and integrating feedback data, performed by the assessing user; v) sending the assessed data packet to the remote mass storage module; vi) viewing the assessed data packet and receiving the integrated feedback.
G09B 23/34 - Anatomical models with removable parts
96.
Monoclonal antibodies specifically for the antigen P of the human respiratory syncytial virus, produced and secreted by the cells hybridomas, useful for detection and diagnostic of the infection caused by RSV
Monoclonal antibodies or fragments thereof are disclosed, which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which has a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID 5 or a variable region of the light chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No:2 or SEQ ID No: 6. Also provided are diagnostic methods ex vivo or in vitro for detection of the viral antigen P of RSV, in which are used the monoclonal antibodies produced and secreted by the hybridomas 2E6/D2 and 6H5/H1. The invention can be used in detection for RSV kits, having the antibodies produced by the mentioned hybridomas.
A61K 39/00 - Medicinal preparations containing antigens or antibodies
97.
IN-SITU MANUFACTURE OF MONOLITHIC STRATIFIED-CONCRETE PANELS HAVING VARIABLE THICKNESS AND DENSITY; AND USE AS THERMAL INSULATION PANELS OF AN ENVELOPE OR ACOUSTIC INSULATORS
The present invention relates to a method for preparing a stratified-concrete panel with at least one layer of structural concrete and at least one layer of thermally and acoustically insulating concrete, using only a process of concreting and placement. This allows the elimination of the extra tasks of adding insulating material to the concrete structures, thereby increasing the productivity of the construction processes. The invention also relates to a stratified-concrete panel and to the use thereof as a construction structure, such as walls and slabs of the envelopes of dwellings, residential or industrial buildings, and acoustic insulation road barriers, the panel having good thermal behaviour and acoustic insulation behaviour.
B28B 23/00 - Arrangements specially adapted for the production of shaped articles with elements wholly or partly embedded in the moulding material
B28B 23/20 - Arrangements specially adapted for the production of shaped articles with elements wholly or partly embedded in the moulding material wherein the elements are reinforcing members the shaping being effected by centrifugal or rotational moulding
C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
Device for recording the vascular response of the human spinal cord triggered by a suprasensible stimulus through the use of functional near-infrared spectroscopy
The invention consists of a device to evaluate hemodynamic response generated by the spinal cord in response to a suprasensorial stimulus applied to a peripheral nerve (medium or posterior tibial) by the use of functional near-infrared spectroscopy (fNIRS). The device consists of 3 main components, an electrical stimulator, an optical recording unit and a signal processing and control module. The device allows non-invasive, comfortable, harmless, portable, home-based, and low-cost evaluation of changes in local hemodynamic parameters in response to neuronal activation of the spinal cord by electrical stimulation of a peripheral nerve. The invention also includes a corresponding method of using the device and monitoring the spinal function.
The present invention consists of functionalised NDs (fNDs) -housing stable fluorescent colour centres- with a bifunctional peptide capable of recognising extracellular amyloid-beta aggregates (Aß) and the accumulation thereof, which is considered the true cause of neuronal damage and cognitive decline in AD. fNDs are not cytotoxic and enable ultrasensitive detection (using picomolar Nd concentrations) of amyloid fibrils and amyloid aggregates. Moreover, the fluorescence of fNDs is more stable than the common colour markers used to dye Aß, such as Thioflavin T.
The invention consists of a formulation that allows the protection of polyphenols, particularly those obtained from bee pollen extract, such as to maintain their antioxidant activities and enable their use as food additives. This formulation corresponds to a triple nanoemulsion (water-oil-water, W/O/W) which comprises chitosan, polyphenols and other components that make it possible to properly maintain the W/O/W phases.
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
patents
