A buffering capsule for buffering an anesthetic cartridge may include a housing including a hollow body, a closed distal end including a receptacle, and an opening opposite the closed distal end. The buffering capsule may include a buffering solution disposed within the receptacle and a flexible piston disposed within the receptacle in sealing contact with the buffering solution, wherein the flexible piston is axially movable within the housing. The buffering capsule may include a cannula holder axially movable within the housing and in contact with the flexible piston. The cannula holder may include a cannula fixedly attached to the cannula holder. The flexible piston may be capable of receiving a first sharpened point of the cannula. The buffering solution disposed within the receptacle may be fluidly connected to an anesthetic liquid in an anesthetic cartridge via the cannula. A process for buffering an anesthetic cartridge is also disclosed.
Dental matrices for applying dental veneers, dental veneers, dental instruments for applying dental veneers, dental bridges, matrices for forming and installing dental bridges, and materials for dental veneers and dental bridges, namely, materials curable by UV light
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
dental preparations in the nature of pharmaceutical preparations, namely, a blood clotting aid, preparations for gum retraction and preparations for delivery system for use in human medicine.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Dental preparations in the nature of pharmaceutical preparations, namely, a blood clotting aid, preparations for gum retraction and delivery system for use in human medicine
A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal.
A61K 33/06 - Aluminium, calcium or magnesiumCompounds thereof
A61Q 13/00 - Formulations or additives for perfume preparations
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A61Q 17/02 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
Dental matrices, namely, dental devices for use in tooth restoration; dental instrument rings for use in tooth restoration procedures; dental instrument bands for use in tooth restoration procedures
A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
Goods & Services
Aspirator tips for dental use; evacuator tips for dental use; saliva ejectors for dental use; teeth polishing brushes and applicators for use by dentists; dental instruments, namely, picks, burrs, mirrors, probes, retractors for dental applicators; Mixing spatulas for dental use; protective barrier sleeves, namely, water syringe sleeves, tray sleeves, headrest covers, half chair sleeves, full chair sleeves, universal x-ray sleeves, t-handle sleeves, all for medical and dental equipment; medical trays to hold and/or deliver medicinal instruments Dental micro brushes; Toothbrush heads for electric and manual toothbrushes; Teeth whitening trays sold empty
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
10 - Medical apparatus and instruments
11 - Environmental control apparatus
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
Goods & Services
Non-medicated tooth polishing paste Dental instruments, namely, picks, scrapers, and dental hand pieces UV lights in the nature of sanitizing apparatus using ultraviolet light for sanitizing dental instruments and toothbrushes not for medical purposes; UV lights for sanitizing dental instruments and toothbrushes Toothbrushes; electric toothbrushes; replacement heads for electric toothbrushes; teeth polishing heads for electric toothbrushes; dental floss
A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal.
A61Q 13/00 - Formulations or additives for perfume preparations
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A61Q 17/02 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for topical epithelial cells of mammal.
A61Q 13/00 - Formulations or additives for perfume preparations
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A61Q 17/02 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Hemostatic/retraction pastes; tooth whitening agents; mineralized chemical preparations used for strengthening teeth; composite substances adapted for dental medical use and for the restoration of teeth; fluoride and non-fluoride varnishes used to coat and strengthen teeth, rinse, pastes, and treatment gels used to clean and strengthen teeth; adhesives for use in connection with tooth fillings, crowns and dentures; resin cement and compounds for use in dental restoration and the placements of crowns; root canal cleansers; root canal lubricants; tooth filling materials for use in dental restoration; chemical compounds for use in cleaning dental instruments; permanent and temporary dental cement; dental sealants; and dental solvents
(2) Dental evacuation systems and dental appliances; dental instruments, namely, periotomes, disposable burs, multi-use burs, diamond burs and cutting tools, polishing discs and pastes, retraction caps, prophy angles and hand pieces, ultrasonic inserts cleaners, endodontic posts, amalgam carriers, articulators, matrices, retraction cords, scalers and curettes, polymer based instruments, cryosurgical devices
33.
Buffered microencapsulated compositions and methods
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal.
A61K 33/06 - Aluminium, calcium or magnesiumCompounds thereof
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A61Q 17/02 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
34.
Buffered microencapsulated compositions and methods
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for topical epithelial cells of mammal.
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
A61K 33/06 - Aluminium, calcium or magnesiumCompounds thereof
A61Q 13/00 - Formulations or additives for perfume preparations
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
A61Q 17/02 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations for dental use, in particular, denture base and filling materials, topical anesthetic, hemostatic solution, sodium fluoride solution, materials for oral prophylaxis, prophylaxis paste, enamel micro abrasion material, dental cement, and sealant and solvents; Hemostatic pastes for dental purposes; retraction pastes for dental purposes; tooth whitening agents; re-mineralizing agents for dental purposes; restorative compounds for dental purposes; fluoride and non-fluoride varnishes, rinse, pastes, and treatment gels for dental purposes; bonding agents for dental purposes; resin composites used to adhere crowns for dental purposes; root canal cleansers; root canal lubricants; composite core buildup materials for dental purposes; cleaning agents for dental purposes, in particular enzymatic instrument cleaners, evacuation system cleaners, and dental appliance cleaners; permanent and temporary dental cement; dental sealants; and dental solvents.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Dental pharmaceutical preparations, namely, topical anesthetic, hemostatic solution, sodium fluoride solution, prophylaxis paste, dental cement, and sealant; hemostatic pastes; medicated tooth whitening agents; re-mineralizing agents for strengthening teeth; restorative compounds for tooth restoration; anticavity fluoride and non-fluoride varnishes; bonding agents for dental purposes; dental resin composites used to adhere crowns; medical root canal cleansers; dental root canal lubricants for use by dentists; composite core buildup materials for repairing teeth and for dental crowns and bridges; disinfectant agents, namely, enzymatic instrument cleaners, evacuation system cleaners, and dental appliance cleaners; permanent and temporary dental cement; dental sealants; and dental solvents for use by dentists
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Dental pharmaceutical preparations, namely, denture base and filling materials, topical anesthetic, hemostatic solution, sodium fluoride solution, prophylaxis paste, enamel micro abrasion material, kits containing moldable compounds used in podiatric applications; hemostatic/retraction pastes; tooth whitening agents; Mineralized chemical preparations used for strengthening teeth; Composite substances adapted for dental medical use and for the restoration of teeth; Fluoride and non-fluoride varnishes used to coat and strengthen teeth, Rinse, pastes, and treatment gels used to clean and strengthen teeth; Adhesives for use in connection with tooth fillings, crowns and dentures; Resin cement and compounds for use in dental restoration and the placement of crowns; root canal cleansers; root canal lubricants; Tooth filling materials for use in dental restoration; Chemical compounds for use in cleaning dental instruments, dental evacuation systems, and dental appliances; permanent and temporary dental cement; dental sealants; and Dental solvents used in connection with cleaning teeth, crowns and dentures; Dental instruments, namely, excavators, burnishers, elevators, carvers, spatulas, mandrels, grinding disks, drills, burs, broaches, reamers, files, chisels, angulators, ejectors, explorers, knives, probes, hemostats, crown removers, crown gauges, syringes and impression trays, root canal instruments, cavity preparation instruments, cord packers, condensers, filling instruments, periodontal instruments, aspiration tubes, skin hooks and needle holders; medical instruments, namely, tracheostomy and laryngectomy tubes and tube brushes, dilators and retractors, suction tubes, forceps, punches, clamps, borers, curettes, cannulae, tenacula hooks, needle and catheter guides, speculas, extractors, probes, scissors, trocars, manipulators, podiatry burs and sterilizers, needle holders, mallets, elevators and rasps, electrosurgical generators, electrodes, needle adaptors, evacuators, air filtration system comprised of an evacuator in combination with a dual stage filter pack for electrosurgical procedures, sounds, urethral catheters, dermal punches, hooks, retractors, dermabraders, nippers, sterilizers; Polishing discs and pastes for use in cleaning teeth, crowns and dentures, retraction caps, prophy angles and instruments used in dental surgery, Process of cleaning teeth, crowns and dentures using ultrasonic waves, endodontic posts, amalgam carriers, articulators, retraction cords, scalers and curettes; Dental instruments made of polymer-based substances, instruments used in connection with surgery that destroys tissues by freezing
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Anti-cavity, non-flouride mouth varnishes, rinse, pastes and treatment gels (non-medicated). Dental hemostatic and retraction pastes; tooth whitening agents; re-mineralizing agents for strengthening teeth; restorative compounds for tooth restoration; anti-cavity dental fluoride varnishes, rinse, pastes, and treatment gels; bonding agents for dental purposes; dental resin composites used to adhere crowns; dental root canal cleansers for use by dentists; dental root canal lubricants for use by dentists; composite core buildup materials for repairing teeth and for dental crowns and bridges; disinfectant agents, namely, enzymatic dental instrument cleaners, dental evacuation system cleaners, and dental appliance cleaners; permanent and temporary dental cement; dental sealants; and dental solvents for use by dental professionals; Anti-cavity, non-flouride mouth varnishes, rinse, pastes and treatment gels.
A dental tool includes: a hollow handle having an open end and a first channel along at least a portion of its longitudinal extent; a dowel fixedly arranged within the first channel such that a face at a longitudinal end of the dowel is aligned with the end opening of the hollow handle, the longitudinal extent of the dowel being arranged within the hollow handle; the dowel having a second channel, having a smaller diameter than the first channel, formed in the longitudinal end of the dowel; and a tool head. A pin portion of the tool head is fixedly arranged in the second channel to securely seat the pin portion of the tool head into the second channel so that a functional portion of the tool head extends beyond an end of the handle.
A61C 17/00 - Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prosthesesSaliva removersDental appliances for receiving spittle
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Hemostatic/retraction pastes; tooth whitening agents; mineralized chemical preparations used for strengthening teeth; composite substances adapted for dental medical use and for the restoration of teeth; fluoride and non-fluoride varnishes used to coat and strengthen teeth, rinse, pastes, and treatment gels used to clean and strengthen teeth; adhesives for use in connection with tooth fillings, crowns and dentures; resin cement and compounds for use in dental restoration and the placements of crowns; root canal cleansers; root canal lubricants; tooth filling materials for use in dental restoration; chemical compounds for use in cleaning dental instruments, dental evacuation systems and dental appliances; permanent and temporary dental cement; dental sealants; and dental solvents
(2) Dental instruments, namely, periotomes, disposable burs, multi-use burs, diamond burs and cutting tools, polishing discs and pastes, retraction caps, prophy angles and hand pieces, ultrasonic inserts cleaners, endodontic posts, amalgam carriers, articulators, matrices, retraction cords, scalers and curettes, polymer based instruments, cryosurgical devices
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Hemostatic/retraction pastes; tooth whitening agents; mineralized chemical preparations used for strengthening teeth; composite substances adapted for dental medical use and for the restoration of teeth; fluoride and non-fluoride varnishes used to coat and strengthen teeth, rinse, pastes, and treatment gels used to clean and strengthen teeth; adhesives for use in connection with tooth fillings, crowns and dentures; resin cement and compounds for use in dental restoration and the placements of crowns; root canal cleansers; root canal lubricants; tooth filling materials for use in dental restoration; chemical compounds for use in cleaning dental instruments, dental evacuation systems and dental appliances; permanent and temporary dental cement; dental sealants; and dental solvents
(2) Dental instruments, namely, periotomes, disposable burs, multi-use burs, diamond burs and cutting tools, polishing discs and pastes, retraction caps, prophy angles and hand pieces, ultrasonic inserts cleaners, endodontic posts, amalgam carriers, articulators, matrices, retraction cords, scalers and curettes, polymer based instruments, cryosurgical devices
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
[ Dental hemostatic and retraction pastes; tooth whitening agents; re-mineralizing agents for strengthening teeth; restorative compounds for tooth restoration; anti-cavity dental fluoride varnishes, rinse, pastes, and treatment gels; bonding agents for dental purposes; dental resin composites used to adhere crowns; dental root canal cleansers for use by dentists; dental root canal lubricants for use by dentists; composite core buildup materials for repairing teeth and for dental crowns and bridges; disinfectant agents, namely, enzymatic dental instrument cleaners, dental evacuation system cleaners, and dental appliance cleaners; permanent and temporary dental cement; ] dental sealants [ ; and dental solvents for use by dental professionals ]
A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
A composition comprising microcapsules functionalized with polymerizable functional groups on the surface of said microcapsules wherein the functional groups form covalent bonds with monomers in the continuous phase to enhance the mechanical properties of the composition.
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A method of treatment for enamel with substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Substantially aqueous-free, enamel protectant and enamel repair toothpaste treatments containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpaste treatments indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
A method of treatment for enamel with substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Substantially aqueous-free, enamel protectant and enamel repair toothpastes containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpastes indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
A61K 8/72 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
Substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Substantially aqueous-free, enamel protectant and enamel repair toothpastes containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpastes indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
A method of treatment for enamel with substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Substantially aqueous-free, enamel protectant and repair brushing gels containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and said brushing gels have substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Substantially aqueous-free, enamel protectant and enamel repair toothpaste treatments containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpaste treatments indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Substantially aqueous-free, enamel protectant and enamel repair toothpastes containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpastes indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.
Improved remineralizing and desensitizing compositions containing remineralizing ingredients in aqueous-free emulsions that, in the presence of saliva, form mucoadhesive gels substantive to tooth surfaces; wherein the gels are dissolved by saliva gradually releasing remineralizing ingredients onto tooth surfaces, treatments with these compositions and methods of manufacture.
Improved remineralizing and desensitizing compositions containing remineralizing ingredients in aqueous-free emulsions that, in the presence of saliva, form mucoadhesive gels substantive to tooth surfaces; wherein the gels are dissolved by saliva gradually releasing remineralizing ingredients onto tooth surfaces, treatments with these compositions and methods of manufacture.
Topical, UBIQUINOL, adjunctive, supplement compositions, containing amorphous calcium phosphate fluoride (ACPF), useful in: reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing hydroxyapatite; comprising: UBIQUINOL in an aqueous-free emulsion that also contains: a stabilizing composition for UBIQUINOL, spilanthes extract, a trans-oral mucosal, absorption facilitator and ACPF; wherein: the emulsion forms a mucoadhesive gel in the presence of saliva that undergoes gradual saliva dissolution effecting passive diffusion of the UBIQUINOL supplement and the spilanthes extract into the oral mucosa, and remineralizing of tooth surfaces with ACPF; resulting in: adjunctively increasing UBIQUINOL levels, reducing oxidative stress, regulating immune response, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces.
Topical, vitamin D, oral supplement compositions useful in treating oral inflammation comprising vitamin D in an aqueous-free emulsion containing a trans-oral mucosal absorption facilitator, where said emulsion forms a mucoadhesive coating in the presence of saliva; wherein saliva dissolution of the mucoadhesive gel releases vitamin D and the trans-oral mucosal, absorption facilitator; effecting: vitamin D passive diffusion; regulating in vivo availability and immune response of vitamin D; and maintaining adequate levels of circulating vitamin D while minimizing the risk of hypercalcemia.
Improved remineralizing and desensitizing compositions containing remineralizing ingredients in aqueous-free emulsions that, in the presence of saliva, form mucoadhesive gels substantive to tooth surfaces; wherein the gels are dissolved by saliva gradually releasing remineralizing ingredients onto tooth surfaces, treatments with these compositions and methods of manufacture.
Topical vitamin D oral supplement compositions useful in treating oral inflammation include an aqueous-free saliva- soluble emulsion carrier, an effective amount of a vitamin D supplement and a trans-oral mucosal absorption facilitator. The emulsion forms a mucoadhesive coating in the presence of saliva, and saliva dissolution of the mucoadhesive gel releases vitamin D and the trans-oral mucosal, absorption facilitator, effecting vitamin D passive diffusion through the oral mucosa. The controlled release of the vitamin D supplement regulates in vivo availability and immune response of vitamin D and maintains adequate levels of circulating vitamin D while minimizing the risk of hypercalcemia.
A61K 31/59 - Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
93.
TOPICAL VITAMIN D AND UBIQUINOL ORAL SUPPLEMENT COMPOSITIONS
A topical vitamin D and UBIQUINOL supplement composition useful in treating oral inflammation and reducing oxidative stress comprising: a supplement mixture of vitamin D and UBIQUINOL in an aqueous-free emulsion containing: spilanthes extract, stabilizing compositions for UBIQUINOL and trans-oral mucosal absorption facilitators for the supplement mixture; where the emulsion forms a mucoadhesive gel in the presence of saliva, that effects passive diffusion through the oral mucosa of the supplement mixture and spilanthes extract regulating: in vivo availability and immune response of the supplement mixture, and maintaining adequate levels of circulating vitamin D and of adjunctively administered UBIQUINOL, while minimizing the risk of hypercalcemia.
Topical, UBIQUINOL, adjunctive, supplement compositions, containing amorphous calcium phosphate fluoride (ACPF), useful in: reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing hydroxyapatite; comprising: UBIQUINOL in an aqueous-free emulsion that also contains: a stabilizing composition for UBIQUINOL, spilanthes extract, a trans-oral mucosal, absorption facilitator and ACPF; wherein: the emulsion forms a mucoadhesive gel in the presence of saliva that undergoes gradual saliva dissolution effecting passive diffusion of the UBIQUINOL supplement and the spilanthes extract into the oral mucosa, and remineralizing of tooth surfaces with ACPF; resulting in: adjunctively increasing UBIQUINOL levels, reducing oxidative stress, regulating immune response, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces
A topical vitamin D and UBIQUINOL supplement composition useful in treating oral inflammation and reducing oxidative stress comprising: a supplement mixture of vitamin D and UBIQUINOL in an aqueous-free emulsion containing: spilanthes extract, stabilizing compositions for UBIQUINOL and trans-oral mucosal absorption facilitators for the supplement mixture; where the emulsion forms a mucoadhesive gel in the presence of saliva, that effects passive diffusion through the oral mucosa of the supplement mixture and spilanthes extract regulating: in vivo availability and immune response of the supplement mixture, and maintaining adequate levels of circulating vitamin D and of adjunctively administered UBIQUINOL, while minimizing the risk of hypercalcemia.
Topical, UBIQUINOL, adjunctive, supplement compositions, containing amorphous calcium phosphate fluoride (ACPF), useful in: reducing oxidative stress, relieving oral discomfort and dry mouth, and remineralizing hydroxyapatite; comprising: UBIQUINOL in an aqueous-free emulsion that also contains: a stabilizing composition for UBIQUINOL, spilanthes extract, a trans-oral mucosal, absorption facilitator and ACPF; wherein: the emulsion forms a mucoadhesive gel in the presence of saliva that undergoes gradual saliva dissolution effecting passive diffusion of the UBIQUINOL supplement and the spilanthes extract into the oral mucosa, and remineralizing of tooth surfaces with ACPF; resulting in: adjunctively increasing UBIQUINOL levels, reducing oxidative stress, regulating immune response, relieving oral discomfort and dry mouth, and remineralizing tooth surfaces
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
B32B 5/16 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer formed of particles, e.g. chips, chopped fibres, powder
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
