A valve includes a valve seat body received by a sleeve with an interference fit between the valve seat body and the sleeve. An upper end of the sleeve extends beyond an upper end of the valve seat body. A valve assembly including the valve is also provided.
A valve includes a valve seat body received by a sleeve with an interference fit between the valve seat body and the sleeve. An upper end of the sleeve extends beyond an upper end of the valve seat body. A valve assembly including the valve is also provided.
B65D 47/06 - Closures with discharging devices other than pumps with pouring spouts or tubesClosures with discharging devices other than pumps with discharge nozzles or passages
A47G 19/22 - Drinking vessels or saucers used for table service
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
3.
HIGH PRESSURE, WEAR RESISTANT VALVE FOR STOP FLOW AND/OR THROTTLING CONTROL
A valve includes a valve seat body received by a sleeve with an interference fit between the valve seat body and the sleeve. An upper end of the sleeve extends beyond an upper end of the valve seat body. A valve assembly including the valve is also provided.
B65D 47/06 - Closures with discharging devices other than pumps with pouring spouts or tubesClosures with discharging devices other than pumps with discharge nozzles or passages
A47G 19/22 - Drinking vessels or saucers used for table service
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
4.
Ultrahigh pressure compact valve with throttling capability
A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.
F16K 1/12 - Lift valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with streamlined valve member around which the fluid flows when the valve is opened
F16K 3/24 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with sealing faces shaped as surfaces of solids of revolution with cylindrical valve members
F16K 1/14 - Lift valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with ball-shaped valve members
F16K 31/62 - Pedals or like operating members, e.g. actuated by knee or hip
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
F16K 31/04 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a motor
F16K 31/163 - Operating meansReleasing devices actuated by fluid with a mechanism, other than pulling- or pushing-rod, between fluid motor and closure member the fluid acting on a piston
F16K 31/10 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a magnet with additional mechanism between armature and closure member
5.
System for high pressure, high shear processing of fluids
A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.
F04B 9/117 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid having plural pumping chambers the pumping members not being mechanically connected to each other
F04B 15/02 - Pumps adapted to handle specific fluids, e.g. by selection of specific materials for pumps or pump parts the fluids being viscous or non-homogeneous
F04B 9/113 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid having plural pumping chambers with two mechanically connected pumping members reciprocating movement of the pumping members being obtained by a double-acting liquid motor
A23L 3/015 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress
F15B 3/00 - Intensifiers or fluid-pressure converters, e.g. pressure exchangersConveying pressure from one fluid system to another, without contact between the fluids
F04B 37/12 - Pumps specially adapted for elastic fluids and having pertinent characteristics not provided for in, or of interest apart from, groups for special use to obtain high pressure
F04B 19/22 - Other positive-displacement pumps of reciprocating-piston type
Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.
A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.
F16K 3/24 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with sealing faces shaped as surfaces of solids of revolution with cylindrical valve members
F16K 1/12 - Lift valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with streamlined valve member around which the fluid flows when the valve is opened
A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.
F16K 3/24 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with sealing faces shaped as surfaces of solids of revolution with cylindrical valve members
F16K 1/12 - Lift valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with streamlined valve member around which the fluid flows when the valve is opened
A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.
F04B 9/115 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid having plural pumping chambers with two mechanically connected pumping members reciprocating movement of the pumping members being obtained by two single-acting liquid motors, each acting in one direction
A23L 3/015 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress
F04B 9/10 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid
F04B 9/103 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid having only one pumping chamber
F04B 9/107 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid having only one pumping chamber rectilinear movement of the pumping member in the working direction being obtained by a single-acting liquid motor, e.g. actuated in the other direction by gravity or a spring
F04B 15/00 - Pumps adapted to handle specific fluids, e.g. by selection of specific materials for pumps or pump parts
10.
SYSTEM FOR HIGH PRESSURE, HIGH SHEAR PROCESSING OF FLUIDS
A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.
F04B 9/10 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid
A23P 30/00 - Shaping or working of foodstuffs characterised by the process or apparatus
A23L 3/015 - Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with pressure variation, shock, acceleration or shear stress
F04B 15/00 - Pumps adapted to handle specific fluids, e.g. by selection of specific materials for pumps or pump parts
F04B 37/12 - Pumps specially adapted for elastic fluids and having pertinent characteristics not provided for in, or of interest apart from, groups for special use to obtain high pressure
Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.
Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.
The present invention is related to systems and methods for chemical and biological analysis and, in particular, to systems, apparatus, and methods of sample conditioning and analysis.
G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
G01R 33/60 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance
The invention provides methods and systems for production of recombinant protein, and particularly, for production of recombinant protein from inclusion bodies. For example, in one aspect, the method comprises providing a protein preparation comprising inclusion bodies, preparing an inclusion body dispersion, and exposing the protein preparation to high pressure in a pressure vessel, to disaggregate and refold the inclusion body protein.
The present invention is related to systems and methods for chemical and biological analysis and, in particular, to systems, apparatus, and methods of sample conditioning and analysis.
The present invention is related to systems and methods for chemical and biological analysis and, in particular, to systems, apparatus, and methods of sample conditioning and analysis.
Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.
A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.
C12M 1/40 - Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
Sample processing devices having collapsible, flexible bodies are disclosed. The flexible microtube sampling devices are utilizable in pressure mediated, pressure cycling procedures. Externally applied pressure on the flexible microtube sample processing devices allow buckling thereof and transfer of the applied pressure to the sample contained therein.
The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pumps and parts and fittings therefor; pumps for research and laboratory use. Scientific and research apparatus and instruments; electrical and electronic apparatus and instruments; pressure generating apparatus and instruments; pressure monitoring apparatus; apparatus and instruments for generating hydrostatic pressure on samples within a pressure chamber. Scientific and technological services and research and design relating thereto; industrial analysis and research services.
09 - Scientific and electric apparatus and instruments
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
Goods & Services
Scientific apparatus and instruments; laboratory apparatus and instruments; test tubes; apparatus, instruments and tubes for the transportation, storage or processing of samples. Containers; containers for samples.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Industrial chemicals, including chemical preparations for the production of pharmaceuticals. Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use; food for babies; plasters, medical dressings; teeth filling material, dental impression materials; disinfectants; preparations for destroying vermin; fungicides, herbicides; chemical and diagnostic preparations for medical, pharmaceutical and veterinary purposes; medical and biological test kits; enzyme preparations for medical and veterinary purposes; sample preparations for molecular diagnostic applications and the production of pharmaceuticals.
