The invention provides a process for manufacturing softgel capsules incorporating within said capsule one or more flat round tablets, said process comprising: (i) loading said flat round tablets into a tablet hopper; (ii) feeding said flat round tablets in a vertical orientation into guide channels; (iii) allowing said flat round tablets to move in the vertical orientation along the guide channels by the effect of gravity; (iv) allowing said flat round tablets to pass through a system incorporating a first retention piston and a second delivery piston; (v) allowing said flat round tablets to enter a distributor plate and wedge segment system through the top feed holes in said distributor plate; and (vi) incorporating said flat round tablets into the interior of the softgel capsule.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
B65B 9/04 - Enclosing successive articles, or quantities of material, between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
B65B 43/08 - Forming three-dimensional containers from sheet material
B65B 47/02 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved with means for heating the material prior to forming
B65B 47/10 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved by application of fluid pressure by vacuum
The present invention relates to a formulation of Ivermectin in oral solution which allows proper absorption, enabling the drug to be consumed at any time. In particular, the oral lipid composition is designed with the appropriate selection of a medium-chain triglyceride oil, a hydrophilic cosolvent and an antioxidant, so as to influence the absorption/digestibility of the poorly water-soluble active ingredient and facilitate bioavailability and bioactivity for the administration of the oral solution in drops. The formulation includes Ivermectin in a lipid medium including a cosolvent and an antioxidant in combination with an oily solvent to form an oral solution for administration in drops. The field of the invention is related to improving the bioavailability of insoluble drugs such as Ivermectin for administration in oral drop forms based mainly on lipids without compromising stability or creating impurities.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Advertising and advertisement services; Assistance in business management and product commercialization; Business administration and office work; Business management; Commercial administration of the licensing of the goods and services of others; Distributorship services in the field of pharmaceutical, veterinary and food products; Import and export agencies Fungicides; Herbicides; Poultices; Baby food; Capsules sold empty for pharmaceuticals; Dietary and nutritional supplements; Disinfectants for hygiene purposes; Molding wax for dental use; Teeth filling material; Preparations for destroying noxious animals
4.
Pre-filling system to eliminate bubbles inside capsules having a solid dosage forms within said capsules
The invention provides a rotary die mold process for manufacturing softgel capsules incorporating another solid form within said capsule and wherein said softgel capsule is free of air bubbles, in which at least two material strips are brought together by means of counter-running forming rolls and formed into capsules, a liquid and solid filling material being introduced via a filling wedge segment comprising two concave wedge surfaces; a filling medicine inlet; a fill medicine outlet; an output of solids and pre-fill medicine; a solids feed channel and pre-fill medicine; a pre-filling medicine inlet and a solids inlet. A softgel capsule free of air bubbles having incorporated within said capsule a second solid form, said second solid form being the form of a tablet.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
The present invention relates to a formulation of Ivermectin in oral solution which allows proper absorption, enabling the drug to be consumed at any time. In particular, the oral lipid composition is designed with the appropriate selection of a medium-chain triglyceride oil, a hydrophilic cosolvent and an antioxidant, so as to influence the absorption/digestibility of the poorly water-soluble active ingredient and facilitate bioavailability and bioactivity for the administration of the oral solution in drops. The formulation includes Ivermectin in a lipid medium including a cosolvent and an antioxidant in combination with an oily solvent to form an oral solution for administration in drops. The field of the invention is related to improving the bioavailability of insoluble drugs such as Ivermectin for administration in oral drop forms based mainly on lipids without compromising stability or creating impurities.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
The present invention relates to a formulation of Ivermectin in soft capsules. In particular, the present invention relates to a formulation of Ivermectin in soft capsules which allows proper absorption in water, allowing the drug to be consumed at any time. Ivermectin, as an insoluble active ingredient, according to the invention, can be formulated in a liquid solution without compromising its stability and without creating impurities to form a suitable soft gelatin capsule. Therefore, the invention comprises a formulation comprising Ivermectin in a lipid medium which includes a surfactant in combination with an oily solvent, a co-surfactant and an oxidant, to form a soft capsule comprising a collagen coating, a plasticiser and gelatin. The field of the invention relates to improving the bioavailability of insoluble drugs such as Ivermectin for delivery in oral soft gelatin capsule forms.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Baby food; Bandages for dressings; Dietary and nutritional supplements; Dietary supplements for animals; Dietary supplements for humans; Dietetic foods adapted for medical purposes; Dietetic foods adapted for medical use; Dietetic foods adapted for veterinary use; Dietetic foods and beverages adapted for medical use; Disinfectants for hygiene purposes; Disinfectants for hygienic purposes; Disinfectants for sanitary purposes; Food supplements; Gauze for dressings; Material for repairing teeth and for dental crowns and bridges; Materials for dental fillings and for sealing purposes; Medical preparations for the treatment of diabetes; Pharmaceutical preparations for the prevention of diabetes; Pharmaceutical preparations for the treatment and prevention of diabetes; Pharmaceutical preparations for the treatment of diabetes; Sanitary preparations for medical purposes; Sanitary preparations for medical use; Sanitary sterilizing preparations; Veterinary preparations for diabetes; Veterinary pharmaceutical preparations for the prevention of diabetes; Veterinary pharmaceutical preparations for the treatment of diabetes; Adhesive bandages; Adhesive for bandages for skin wounds; Chemical preparations for sanitary purposes; Chemical preparations for sanitary use; Medical dressings; Sterilized dressing; Surgical bandages; Surgical dressings; Wound dressings
The invention provides a filter fabric for providing anti pathogenic properties which has been coated with a composition comprising (a) 0.0001-99.9999% by weight of a compound of such as zinc pyrithione and (b) 0.0001-99.9999% by weight of an additional zinc salt selected from the group consisting of zinc acetate, zinc propionate, zinc oxalate, zinc benzoate, zinc gluconate, zinc ascorbate, zinc citrate, zinc lactate, zinc glycolate, zinc maleate, zinc fumarate, zinc polyacrylate and zinc polymaleate. The invention also provides a composition for imparting anti-viral properties to a breathable substrate material comprising two or more zinc salts selected from the group consisting of zinc acetate, zinc propionate, zinc oxalate, zinc benzoate, zinc gluconate, zinc ascorbate, zinc citrate, zinc lactate, zinc glycolate, zinc maleate, zinc fumarate, zinc EDTA, zinc glycinate, zinc polyacrylate, zinc polylactate, zinc polyglycolate and zinc polymaleate said zinc salts being present in effective amounts to impart anti-pathogenic properties.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying noxious animals; Fungicides, herbicides.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals, medical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying noxious animals; Fungicides, herbicides.
11.
CHEWABLE HEAT-RESISTANT ORAL DOSAGE FORM WITH AN AGAR MATRIX AND PRODUCTION METHOD FOR OBTAINING THE CHEWABLE ORAL DOSAGE FORM
The present invention defines a process for forming a chewable oral dosage form, such as a gum having a pleasant flavour and texture. In particular, the invention includes a process of forming an oral dosage form, comprising: a first step of hydrating a gelling agent of agar-agar and locust bean gum; a second step of mixing in components of the agar matrix; a third step of mixing in an active ingredient; a fourth step of cooking the mixture; a fifth step of flavouring; a sixth step of moulding and gelling; and a seventh step of demoulding, degreasing and drying. The oral dosage form according to the invention also comprises an agar-agar matrix combined with gums, such as locust bean gum, and/or sugar; glycerol; inulin; flavouring agents; citric acid; a coating; and water, to complete the composition, which includes active ingredients.
A23L 29/238 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
A23L 29/256 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
A23G 3/48 - Sweetmeats, confectionery or marzipanProcesses for the preparation thereof characterised by the composition containing plants or parts thereof, e.g. fruits, seeds, extracts
A23G 4/08 - Chewing gum characterised by the composition of the chewing gum base
A61K 9/34 - Organic coatings containing natural gums or resins
A61K 9/68 - Medicinal preparations characterised by special physical form chewing gum type
cyclanthera pedata plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
16.
Cyclanthera pedata and formulations and uses thereof
Cyclanthera pedata plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
17.
COMPOSITIONS FOR TREATING INFECTIONS CAUSED BY THE MITE DEMODEX SPP
The invention relates to compositions for treating infections caused by the mite Demodex spp, said compositions comprising essential oils selected from the group consisting of Eruca sativa oil, Zingiber officinale oil, and Alpinia officinarum oil incorporated into solvents and vehicles, and presented in a kit in the form of a solution, a suspension, an emulsion or a dispersion. They are topically applied for the treatment of infections and disorders caused by Demodex spp in humans.
The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61J 7/00 - Devices for administering medicines orally, e.g. spoonsPill counting devicesArrangements for time indication or reminder for taking medicine
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
B65D 83/04 - Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills
19.
Electronic dosage dispensing system for filling softgel capsules
The invention relates to a rotary die device for producing soft capsules, comprising a capsule forming unit for forming a soft-capsule shell and a novel dosing unit for feeding a filling material into the capsule forming unit, characterized in that the dosing unit comprises a dispensing system that includes (a) a container defining a reservoir for storing therapeutic or non-therapeutic compositions; (b) a low pressure pump; (c) a high pressure peristaltic pump; (d) a supply line for the therapeutic or non-therapeutic compositions; and (d) one or more electromagnetically activated nozzles/injectors to fill the softgel capsules with the therapeutic or non-therapeutic compositions.
B29C 47/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor (extrusion blow-moulding B29C 49/04)
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
20.
Method and apparatus for printing on soft gelatin capsules during forming
The invention relates to a method and apparatus for printing on the surface of soft gelatin capsules during filling. In particular, the invention relates to an apparatus and method for printing a pre-determined figure or symbol on the surface of a soft gelatin capsule while a product is being encapsulated, including means for transporting the gelatin ribbon, inking means and means for shaping the soft capsule, including an injection, molding and die-cutting station and additional printing means.
B41F 17/36 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on tablets, pills, or like small articles
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
B65B 47/00 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved
21.
APPARATUS AND PROCESS FOR ENCAPSULATING CAPSULES OR OTHER SOLID DOSAGE FORMS WITHIN CAPSULES
The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
The invention provides an apparatus for producing soft gel capsules having encapsulated therein microparticles, nanoparticles and fluids, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies; (d) a liquid fill system (medicine pump system); (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) one or more microgranule or nanogranule feeders located on each side of the rotary dies, said feeders being synchronized to rotate at the same tangential speed as the rotary dies.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
An apparatus for making softgel capsules comprising: two extrusion nozzles; two cooling and tension rollers; two rotary dies; a wedge; and a filling station. A method is also provided for for producing softgel capsules, comprising the steps of: (a) softening or melting a suitable film forming composition; (b) extruding said suitable film forming composition through two extrusion dies directly into two tension rollers; (c) passing the extruded films over rotating dies; (d) simultaneously forming, filling, heat-sealing and cutting capsules; and (e) washing and drying said capsules.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
The invention relates to a method and apparatus for printing on the surface of soft gelatin capsules during filling. In particular, the invention relates to an apparatus and method for printing a pre-determined figure or symbol on the surface of a soft gelatin capsule while a product is being encapsulated, including means for transporting the gelatin ribbon, inking means and means for shaping the soft capsule, including an injection, moulding and die-cutting station and additional printing means.
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
B41F 17/36 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on tablets, pills, or like small articles
B65B 47/00 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved
27.
METHOD AND APPARATUS FOR PRINTING ON SOFT GELATIN CAPSULES DURING FORMING
The invention relates to a method and apparatus for printing on the surface of soft gelatin capsules during filling. In particular, the invention relates to an apparatus and method for printing a pre-determined figure or symbol on the surface of a soft gelatin capsule while a product is being encapsulated, including means for transporting the gelatin ribbon, inking means and means for shaping the soft capsule, including an injection, moulding and die-cutting station and additional printing means.
B41F 17/36 - Printing apparatus or machines of special types or for particular purposes, not otherwise provided for for printing on tablets, pills, or like small articles
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
B65B 47/00 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved
39 - Transport, packaging, storage and travel services
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Advertising services, commercial business management; commercial administration; office functions; import, export, purchasing and sales of consumer goods and products of all kinds, in particular foodstuffs, cosmetics. Distribution of consumer goods and products of all kinds, in particular foodstuffs, cosmetics. Manufacture of consumer goods and products of all kinds, in particular foodstuffs.
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Balls, "paintball" balls, sports balls, gymnastics and sporting apparatus and articles of all kinds, gymnastics instruments and articles, games, playthings and toy pistols. Organisation and development of games and sporting activities of a sports club, in particular "paintball", educational activities, and services for conducting seminars and events relating to the field of medicine, activities intended for teaching sports and similar, cultural activities, ticket sales. Research applied to the field of medicine and topics relating to health matters. Medical assistance for sports and games.
