C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
2.
POLYMERS, COMPOSITIONS, AND METHODS FOR ISOLATION OF NUCLEIC ACIDS
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C08F 26/06 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemicals, namely, nucleic acids, buffers, mixtures, and
oils for scientific research purposes; chemicals for
performing polymerase chain reaction (PCR) for scientific
research purposes; assays for scientific research purposes;
analyte detection kits for scientific research purposes;
magnetic beads for scientific research purposes; carrier
beads for analyte detection systems; oligonucleotide probes
and primers for scientific research purposes. Laboratory consumables, namely, multiwell plates, lids,
racks, frames, and tubes, all for scientific research
purposes; magnetic laboratory accessories, namely, multiwell
plates, lids, racks, frames, and tubes, all for scientific
research purposes; scientific laboratory research
instruments for detection of analytes; scientific laboratory
research apparatuses and instruments for detection of
fluorescence or luminescence; scientific laboratory research
apparatuses and instruments for amplification of nucleic
acids; apparatuses and instruments for handling of fluids
and reagents for scientific research purposes; downloadable
software for use with scientific laboratory research
instruments for detection of analytes, detection of
fluorescence or luminescence, amplification of nucleic
acids, and handling of fluids and reagents for scientific
research purposes.
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory consumables, namely, multiwell plates, lids,
racks, frames, and tubes, all for scientific research
purposes; magnetic laboratory accessories, namely, multiwell
plates, lids, racks, frames, and tubes, all for scientific
research purposes; scientific laboratory research
instruments for detection of analytes; scientific laboratory
research apparatuses and instruments for detection of
fluorescence or luminescence; scientific laboratory research
apparatuses and instruments for amplification of nucleic
acids; apparatuses and instruments for handling of fluids
and reagents for scientific research purposes; downloadable
software for use with scientific laboratory research
instruments for detection of analytes, detection of
fluorescence or luminescence, amplification of nucleic
acids, and handling of fluids and reagents for scientific
research purposes.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemicals, namely, nucleic acids, buffers, mixtures, and
oils for scientific research purposes; chemicals for
performing polymerase chain reaction (PCR) for scientific
research purposes; assays for scientific research purposes;
analyte detection kits for scientific research purposes;
magnetic beads for scientific research purposes; carrier
beads for analyte detection systems; oligonucleotide probes
and primers for scientific research purposes.
6.
SYSTEMS AND METHODS FOR WIRELESS INVENTORY MANAGEMENT
A system comprising a shelving unit including a shelf defining a supporting surface. The shelving unit is electrically coupled to a power source and a network. The system further includes a bin removably positioned on the supporting surface; a module removably coupled to the bin; a first wireless component coupled to the shelf and in electrical communication with the network; and a second wireless component coupled to the bin or the module. Electrical power is wirelessly transferred between the first wireless component and the second wireless component. A data set is wirelessly transferred between the first wireless component and the second wireless component. The module is in electrical communication with the network.
A system comprising a shelving unit including a shelf defining a supporting surface. The shelving unit is electrically coupled to a power source and a network. The system further includes a bin removably positioned on the supporting surface; a module removably coupled to the bin; a first wireless component coupled to the shelf and in electrical communication with the network; and a second wireless component coupled to the bin or the module. Electrical power is wirelessly transferred between the first wireless component and the second wireless component. A data set is wirelessly transferred between the first wireless component and the second wireless component. The module is in electrical communication with the network.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical reagents for forensic analysis, paternity testing, and relationship-testing; tests comprised of reagents for forensic analysis, paternity testing, and relationship-testing; kits comprised of reagents for forensic analysis, paternity testing, and relationship-testing; enzymes for forensic analysis, paternity testing, and relationship-testing; tests comprised of enzymes for forensic analysis, paternity testing, and relationship-testing; kits comprised of enzymes for forensic analysis, paternity testing, and relationship-testing; kits and tests comprised primarily of enzymes, buffers, and nucleotides for use in forensic DNA profiling and genetic identification; enzymes, namely, DNA polymerase, for scientific, research, forensic-analysis, paternity-testing, and relationship-testing purposes
9.
LASER ILLUMINATION TECHNIQUES FOR CAPILLARY ELECTROPHORESIS
A laser-line-generating system generates and process a laser light to illuminate a capillary array. The laser-line-generating system includes a laser-light source, focusing optics, a first optical scanner, and a second optical scanner. The laser-light source outputs a first laser light. The focusing optics receives the first laser light and reduces a beam width of the first laser light. The first optical scanner receives the first laser light and output a first optical-scanner-outputted light by varying an angle of outputted light along a first dimension. The second optical scanner receives the first optical-scanner-outputted light and outputs a second optical-scanner-outputted light by varying an angle of outputted light along a second dimension. The second optical-scanner-outputted light includes a line with dimensional components in both the first dimension and the second dimension.
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Chemicals, namely, nucleic acids, buffers, mixtures, and oils for scientific research purposes; chemicals for performing polymerase chain reaction (PCR) for scientific research purposes; assays for scientific research purposes; analyte detection kits for scientific research purposes; magnetic beads for scientific research purposes; carrier beads for analyte detection systems; oligonucleotide probes and primers for scientific research purposes.
(2) Laboratory consumables, namely, multiwell plates, lids, racks, frames, and tubes, all for scientific research purposes; magnetic laboratory accessories, namely, multiwell plates, lids, racks, frames, and tubes, all for scientific research purposes; scientific laboratory research instruments for detection of analytes; scientific laboratory research apparatuses and instruments for detection of fluorescence or luminescence; scientific laboratory research apparatuses and instruments for amplification of nucleic acids; apparatuses and instruments for handling of fluids and reagents for scientific research purposes; downloadable software for use with scientific laboratory research instruments for detection of analytes, detection of fluorescence or luminescence, amplification of nucleic acids, and handling of fluids and reagents for scientific research purposes.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Chemicals, namely, nucleic acids, buffers, mixtures, and oils for scientific research purposes; chemicals for performing polymerase chain reaction (PCR) for scientific research purposes; assays for scientific research purposes; analyte detection kits for scientific research purposes; magnetic beads for scientific research purposes; carrier beads for analyte detection systems; oligonucleotide probes and primers for scientific research purposes.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Laboratory consumables, namely, multiwell plates, lids, racks, frames, and tubes, all for scientific research purposes; magnetic laboratory accessories, namely, multiwell plates, lids, racks, frames, and tubes, all for scientific research purposes; scientific laboratory research instruments for detection of analytes; scientific laboratory research apparatuses and instruments for detection of fluorescence or luminescence; scientific laboratory research apparatuses and instruments for amplification of nucleic acids; apparatuses and instruments for handling of fluids and reagents for scientific research purposes; downloadable software for use with scientific laboratory research instruments for detection of analytes, detection of fluorescence or luminescence, amplification of nucleic acids, and handling of fluids and reagents for scientific research purposes.
13.
ACTIVATION OF BIOLUMINESCENCE BY STRUCTURAL COMPLEMENTATION
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
Provided herein are compositions and methods for purifying and concentrating nucleic acids from large-volume samples. In particular, reagents are provided for non-specifically binding total nucleic acid to a solid surface, separating bound nucleic acid from a large-volume sample, separating nucleic acid from amplification inhibitors, and/or eluting nucleic acids into a small volume amenable to further analysis.
Provided herein are compositions and methods for purifying and concentrating nucleic acids from large-volume samples. In particular, reagents are provided for non-specifically binding total nucleic acid to a solid surface, separating bound nucleic acid from a large-volume sample, separating nucleic acid from amplification inhibitors, and/or eluting nucleic acids into a small volume amenable to further analysis.
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
Provided herein are compositions comprising a double-stranded RNA (dsRNA) binding domains linked to components of a complementation system. Upon binding of a pair of dsRNA binding domains to a dsRNA, a detectable complex of the complementation components is formed, and the dsRNA can be detected/quantified.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Reagents for laboratory, scientific, or research use;
reagents for transferring nucleic acid inside cells for
laboratory, scientific, or research use; mRNA transfection
reagent for laboratory, scientific, or research use.
19.
COMPOUNDS AND METHODS OF USE THEREOF FOR ASSESSING TARGET ENGAGEMENT FOR DNA POLYMERASE THETA
The present invention provides compounds and methods of use thereof for assessing target engagement for DNA polymerase theta. In particular, provided herein are tracer compounds comprising a small molecule that binds DNA polymerase theta tethered to a fluorophore, and methods of use thereof in target engagement assays.
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
C07C 233/64 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
20.
SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF DOUBLE-STRANDED RNA
Provided herein are compositions comprising a double-stranded RNA (dsRNA) binding domains linked to components of a complementation system. Upon binding of a pair of dsRNA binding domains to a dsRNA, a detectable complex of the complementation components is formed, and the dsRNA can be detected/quantified.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
(1) Reagents for laboratory, scientific, or research use; reagents for transferring nucleic acid inside cells for laboratory, scientific, or research use; mRNA transfection reagent for laboratory, scientific, or research use.
Provided herein are systems, methods, and compositions for bioluminescence-triggered photocatalytic activation of molecular entities in a proximity-dependent manner, which can be actuated within biological systems. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts, and activatable molecular entities incorporating light-responsive moieties that restrict their activity; systems thereof; and methods for catalytically activating the activatable molecular entities via bioluminescence-triggered catalysis.
Provided herein are methods, compositions, and kits for decrosslinking formaldehyde cross-linked biological samples such as formalin-fixed, paraffin-embedded (FFPE) tissue samples.
Disclosed herein are compositions and methods for decrosslinking formaldehyde cross-linked biological samples such as formalin-fixed, paraffin-embedded (FFPE) tissue samples.
Provided herein are methods, compositions, and kits for decrosslinking formaldehyde cross-linked biological samples such as formalin-fixed, paraffin-embedded (FFPE) tissue samples.
Disclosed herein are compositions and methods for decrosslinking formaldehyde cross-linked biological samples such as formalin-fixed, paraffin-embedded (FFPE) tissue samples.
Provided herein are compositions and systems comprising complementation-based tags and reporters for labeling and detection of targets by luminescence and a second modality (e.g., fluorescence), and methods of use thereof. In particular, tags are provided comprising the fusion of a first component of bioluminescent complex and a first component of modified dehalogenase complex, reporters are provided comprising the second component of bioluminescent complex and the second component of modified dehalogenase complex, and systems and methods are provided comprising the tags and reporters herein for dual-modality labeling and detection of targets.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
29.
COMPLEMENTATION-BASED TAGS AND REPORTERS FOR DUAL-MODALITY LABELING
Provided herein are compositions and systems comprising complementation-based tags and reporters for labeling and detection of targets by luminescence and a second modality (e.g., fluorescence), and methods of use thereof. In particular, tags are provided comprising the fusion of a first component of bioluminescent complex and a first component of modified dehalogenase complex, reporters are provided comprising the second component of bioluminescent complex and the second component of modified dehalogenase complex, and systems and methods are provided comprising the tags and reporters herein for dual-modality labeling and detection of targets.
Provided herein are compositions and systems comprising a DNA polymerase domain, a thioredoxin binding domain (TBD), and thioredoxin (TRX), wherein one or both of the TRX and TBD are fused or otherwise conjugated to the DNA polymerase domain. A TRX or TBD may also be provided in a system herein as a separate entity (e.g., a binary system). The DNA polymerase/TBD/TRX compositions and systems herein are engineered to reduce stutter and/or to produce fewer stutter artifacts. Kits comprising the DNA polymerase/TBD/TRX compositions and systems herein and methods of use thereof are also within the scope herein.
Provided herein are biotechnology reagents provided with a poloxamer excipient. In particular, haloalkane-linked fluorophores are provided in solution or a lyophilized formulation with a poloxamer that allows for storage, accurate dispensing/measurement, reconstitution, and addition to complex biological samples without the requirement of organic solvents.
Provided herein are biotechnology reagents provided with a poloxamer excipient. In particular, haloalkane-linked fluorophores are provided in solution or a lyophilized formulation with a poloxamer that allows for storage, accurate dispensing/measurement, reconstitution, and addition to complex biological samples without the requirement of organic solvents.
Provided herein are systems, methods, and compositions for bioluminescence-triggered photocatalytic activation of molecular entities in a proximity-dependent manner, which can be actuated within biological systems. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts, and activatable molecular entities incorporating light-responsive moieties that restrict their activity; systems thereof; and methods for catalytically activating the activatable molecular entities via bioluminescence-triggered catalysis.
C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
Provided herein are assays utilizing oxygen-sensitive fluorescent materials for the detection of oxygen. In particular, oxygen-sensitive fluorescent particles are provided for monitoring the oxygen consumption rate and metabolic fitness of living cells.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemicals, namely, nucleic acids, buffers, mixtures, and oils for scientific research purposes; chemicals for performing polymerase chain reaction (PCR) for scientific research purposes; assays for scientific research purposes; analyte detection kits for scientific research purposes; magnetic beads for scientific research purposes; carrier beads for analyte detection systems; oligonucleotide probes and primers for scientific research purposes
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory consumables, namely, multiwell plates, lids, racks, frames, and tubes, all for scientific research purposes; magnetic laboratory accessories, namely, multiwell plates, lids, racks, frames, and tubes, all for scientific research purposes; scientific laboratory research instruments for detection of analytes; scientific laboratory research apparatuses and instruments for detection of fluorescence or luminescence; scientific laboratory research apparatuses and instruments for amplification of nucleic acids; apparatuses and instruments for handling of fluids and reagents for scientific research purposes; downloadable software for use with scientific laboratory research instruments for detection of analytes, detection of fluorescence or luminescence, amplification of nucleic acids, and handling of fluids and reagents for scientific research purposes
Provided herein are assays utilizing oxygen-sensitive fluorescent materials for the detection of oxygen. In particular, oxygen-sensitive fluorescent particles are provided for monitoring the oxygen consumption rate and metabolic fitness of living cells.
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemicals, namely, nucleic acids, buffers, and oil dispersants for scientific research purposes; chemicals for performing polymerase chain reaction (PCR) for scientific research purposes; assays for scientific research purposes, namely PCR-based assay for the detection of nucleic acids; analyte detection kits for scientific research purposes; magnetic beads for scientific research purposes; carrier beads used as a reagent in analyte detection systems; oligonucleotide probes and primers used as a reagent scientific research purposes Laboratory consumables, namely, multi-well plates, lids for multi-well plates, lids for petri dishes, lids for flasks, lids for culture vessels, pipette racks, test tube racks, microcentrifuge tube racks, conical tube racks, multi-well plate racks, multi-well plate frames, PCR plate frames, real-time PCR plate frames, and digital PCR plates frames, test tubes, microcentrifuge tubes, conical tubes, all for scientific research purposes; magnetic laboratory accessories, namely, multi-well plates, lids for multi-well plates, lids for petri dishes, lids for flasks, lids for culture vessels, pipette racks, test tube racks, microcentrifuge tube racks, conical tube racks, multi-well plate racks, multi-well plate frames, PCR plate frames, real-time PCR plate frames, and digital PCR plates frames, test tubes, microcentrifuge tubes, conical tubes, all for scientific research purposes; scientific laboratory research instruments for detection of analytes; scientific laboratory research apparatuses and instruments for detection of fluorescence and luminescence; scientific laboratory research apparatuses and instruments for amplification of nucleic acids; apparatuses and instruments for handling of fluids and reagents for scientific research purposes, namely, automated liquid handlers, automated reagent dispensers, and microfluidic droplet generators; downloadable software for use with scientific laboratory research instruments for the detection of analytes, detection of fluorescence or luminescence, amplification of nucleic acids, and handling of fluids and reagents for scientific research purposes
39.
ENGINEERED DNA POLYMERASE WITH REDUCED ARTIFACT FORMATION
Provided herein are compositions and systems comprising a DNA polymerase domain, a thioredoxin binding domain (TBD), and thioredoxin (TRX), wherein one or both of the TRX and TBD are fused or otherwise conjugated to the DNA polymerase domain. A TRX or TBD may also be provided in a system herein as a separate entity (e.g., a binary system). The DNA polymerase/TBD/TRX compositions and systems herein are engineered to reduce stutter and/or to produce fewer stutter artifacts. Kits comprising the DNA polymerase/TBD/TRX compositions and systems herein and methods of use thereof are also within the scope herein.
Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Reagents for research purposes; reagents for non-medical
purposes; reagents for the development and manufacture of
cell and gene therapy products, namely cells, nucleic acids,
and viral vectors and non-viral vectors in the nature of
nucleic acid carriers, each of the aforementioned for
scientific and research purposes; scientific or medical
research reagents for laboratory use for providing enhanced
accuracy and efficiency in vial genome titer data; small
molecule reagents for scientific or medical research use;
neutralization reagents for scientific or medical research
use; reagents for use in polymerase chain reaction for
scientific or medical research purposes, namely, nucleic
acids, nucleotides, buffers, and enzymes; reagents for use
in sterility assays for use in drug development and
production. Reagents for use in medical genetic testing for providing
enhanced accuracy and efficiency in vial genome titer data;
small molecule reagents for medical use; neutralization
reagents for medical use; reagents for use in polymerase
chain reaction for medical genetic testing purposes, namely,
nucleic acids, nucleotides, buffers, and enzymes.
This invention particularly relates to trifunctional PROTACs of formula I as described herein which bind to a protein within the Bromo- and Extra-Terminal (BET) family of proteins, and especially to PROTACs including small molecule E3 ubiquitin ligase protein binding ligand compounds which induce preferential degradation of the BRD2 protein within the bromodomain of the BET family of proteins.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
09 - Scientific and electric apparatus and instruments
Goods & Services
Bioluminescence assay instruments, namely, luminometers;
luminometers; benchtop instruments for the detection of
luminescence; luminometers capable of receiving a sample in
microwell plate format.
Provided herein are systems, methods, and compositions for bioluminescence-triggered catalysis of bioorthogonal labeling chemistries in a proximity dependent manner. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts or photosensitizers, activatable labels, and systems thereof, and methods of catalytically activating the activatable labels via bioluminescence-triggered catalysis.
The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
C07C 317/28 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
C07D 307/80 - Radicals substituted by oxygen atoms
C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Reagents for laboratory, scientific, or research use; reagents for transferring nucleic acid inside cells for laboratory, scientific, or research use; mRNA transfection reagent for laboratory, scientific, or research use
Provided herein are peptide and polypeptide sequences that structurally assemble to form active, modified dehalogenase structures capable of binding to a haloalkyl ligand. In particular, provided herein are split dehalogenase variants that assemble through structural complementation into active dehalogenase complexes, and systems and methods of use thereof.
An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays. For example, the compounds may be used for in vivo imaging.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
50.
MODIFIED DEHALOGENASE WITH EXTENDED SURFACE LOOP REGIONS
Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Reagents for research purposes; reagents for non-medical purposes; reagents for the development and manufacture of cell and gene therapy products, namely cells, nucleic acids, and viral vectors and non-viral vectors in the nature of nucleic acid carriers, each of the aforementioned for scientific and research purposes; scientific or medical research reagents for laboratory use for providing enhanced accuracy and efficiency in vial genome titer data; small molecule reagents for scientific or medical research use; neutralization reagents for scientific or medical research use; reagents for use in polymerase chain reaction for scientific or medical research purposes, namely, nucleic acids, nucleotides, buffers, and enzymes; reagents for use in sterility assays for use in drug development and production.
(2) Reagents for use in medical genetic testing for providing enhanced accuracy and efficiency in vial genome titer data; small molecule reagents for medical use; neutralization reagents for medical use; reagents for use in polymerase chain reaction for medical genetic testing purposes, namely, nucleic acids, nucleotides, buffers, and enzymes.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Bioluminescence assay instruments, namely, luminometers; luminometers; benchtop instruments for the detection of luminescence; luminometers capable of receiving a sample in microwell plate format.
54.
SUBSTITUTED IMIDAZO[1,2-a]PYRAZINES AS LUCIFERASE SUBSTRATES
Described are substituted imidazo[1,2-a]pyrazine compounds, which are coelenterazine analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays. Also described are methods from making the compounds, such as a method using aminopyrazine acetophosphonates as synthesis intermediates.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
Provided herein are circularly-permuted (cp) dehalogenase variants that are capable of covalently binding to a haloalkyl ligand. In particular cp dehalogenase variants and peptides and polypeptides comprising split versions thereof that structurally assemble to form an active dehalogenase complexes are provided.
Provided herein are polysiloxane matrices and biocompatible films thereof for the detection of oxygen. In particular, oxygen-sensitive fluorophores embedded within polysiloxane matrices are utilized for detection of oxygen consumption rate in living cells.
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
Provided herein are polysiloxane matrices and biocompatible films thereof for the detection of oxygen. In particular, oxygen-sensitive fluorophores embedded within polysiloxane matrices are utilized for detection of oxygen consumption rate in living cells.
C08G 77/50 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages
C08L 83/14 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon onlyCompositions of derivatives of such polymers in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
59.
RECOGNITION OF CELLULAR TARGET BINDING BY A BIOACTIVE AGENT USING INTRACELLULAR BIOLUMINESCENCE RESONANCE ENERGY TRANSFER
Provided herein are compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.
G01N 33/94 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving narcotics
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
60.
LUCIFERASE ENZYMES FOR USE WITH THERMOSTABLE LUCIFERINS IN BIOLUMINESCENT ASSAYS
Provided herein are enhanced luciferase enzymes for use with thermostable luciferin analogs for bioluminescent assays. In particular, the present disclosure provides compositions, assays, and methods for performing a bioluminescent assay using enhanced, high-activity luciferase enzymes compatible with thermostable luciferins, such as 5,5-disubstituted luciferin analogs.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing use of a non-downloadable web-based cloud platform
for connecting, monitoring, and managing research data and
networked instruments (term considered too vague by the
International Bureau - Rule 13 (2) (b) of the Regulations).
62.
COMPOUNDS, COMPOSITIONS, AND METHODS FOR ISOLATION OF NUCLEIC ACIDS
C07D 265/30 - 1,4-OxazinesHydrogenated 1,4-oxazines not condensed with other rings
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C07D 223/14 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07D 249/16 - Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
64.
NUCLEIC ACID CROSSLINKING REAGENTS AND USES THEREOF
Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
C07D 235/20 - Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
Provided herein are compounds, compositions, systems, and methods for photoactivatable labeling, which can be actuated within biological systems. In particular, compounds disclosed herein include vinyl-extended-aryl azide moieties that undergo photoactivation to generate reactive intermediates, which can form covalent linkages with biomolecules. The photoactivation can be conducted by a variety of mechanisms including ultraviolet (UV) irradiation, visible light irradiation, or energy transfer (e.g., from a photocatalyst). The compounds also include functional moieties that provide useful functionalities, for example detection of biomolecules, such as fluorophores, capture elements (e.g., biotin), or reactive moieties (e.g., click handles) and bifunctional moieties comprising a bioactive compound and a detection/capture element.
Provided herein are peptide and polypeptide sequences that structurally assemble to form active, modified dehalogenase structures capable of binding to a haloalkyl ligand. In particular, provided herein are split dehalogenase variants that assemble through structural complementation into active dehalogenase complexes, and systems and methods of use thereof.
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
67.
MODIFIED DEHALOGENASE WITH EXTENDED SURFACE LOOP REGIONS
Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
Provided herein are circularly-permuted (cp) dehalogenase variants that are capable of covalently binding to a haloalkyl ligand. In particular cp dehalogenase variants and peptides and polypeptides comprising split versions thereof that structurally assemble to form an active dehalogenase complexes are provided.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
Provided herein are compounds, compositions, systems, and methods for photoactivatable labeling, which can be actuated within biological systems. In particular, compounds disclosed herein include vinyl-extended-aryl azide moieties that undergo photoactivation to generate reactive intermediates, which can form covalent linkages with biomolecules. The photoactivation can be conducted by a variety of mechanisms including ultraviolet (UV) irradiation, visible light irradiation, or energy transfer (e.g., from a photocatalyst). The compounds also include functional moieties that provide useful functionalities, for example detection of biomolecules, such as fluorophores, capture elements (e.g., biotin), or reactive moieties (e.g., click handles) and bifunctional moieties comprising a bioactive compound and a detection/capture element.
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
Provided herein are systems, methods, and compositions for bioluminescence-triggered catalysis of bioorthogonal labeling chemistries in a proximity dependent manner. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts or photosensitizers, activatable labels, and systems thereof, and methods of catalytically activating the activatable labels via bioluminescence-triggered catalysis.
G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
71.
COMPOUNDS, COMPOSITIONS, AND METHODS FOR ISOLATION OF NUCLEIC ACIDS
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
09 - Scientific and electric apparatus and instruments
Goods & Services
Bioluminescence assay instruments, namely, photometers being luminometers; photometers being luminometers; benchtop instruments for the detection of luminescence being luminometers in the nature of photometers; photometers being luminometers that are capable of receiving a sample in microwell plate format
The present disclosure relates to devices, methods, and systems or kits for detecting ATP in a sample. Particularly, the present disclosure relates to methods for removing ATP contamination from a sample and detecting intracellular ATP in the sample (e.g., as a proxy for detecting live cells in the sample).
G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
The present disclosure relates to devices, methods, and systems or kits for detecting ATP in a sample. Particularly, the present disclosure relates to methods for removing ATP contamination from a sample and detecting intracellular ATP in the sample (e.g., as a proxy for detecting live cells in the sample).
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
78.
NUCLEIC ACID CROSSLINKING REAGENTS AND USES THEREOF
Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
C09B 23/16 - Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms
C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
79.
OXAZINE DYES AND THEIR USE IN NUCLEIC ACID AMPLIFICATION REACTIONS
Disclosed herein are functionalized oxazine dye compounds, compositions comprising the compounds, and methods of using the compounds, e.g., in nucleic acid amplification reactions. Also disclosed herein are labeled oligonucleotides and labeled nucleotide triphosphate compounds.
Disclosed herein are functionalized oxazine dye compounds, compositions comprising the compounds, and methods of using the compounds, e.g., in nucleic acid amplification reactions. Also disclosed herein are labeled oligonucleotides and labeled nucleotide triphosphate compounds.
C07H 19/00 - Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radicalNucleosidesMononucleotidesAnhydro derivatives thereof
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Providing use of a non-downloadable web-based cloud platform for connecting, monitoring, and managing research data and networked instruments (term considered too vague by the International Bureau - Rule 13 (2) (b) of the Regulations).
The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.
C07C 309/10 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
C07C 309/14 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
C07C 309/15 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups X being a hetero atom, Y being any atom
C07C 309/16 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing doubly-bound nitrogen atoms bound to the carbon skeleton
C07C 323/12 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
C07C 329/06 - Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
C07D 307/40 - Radicals substituted by oxygen atoms
C07D 307/56 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 317/22 - Radicals substituted by singly bound oxygen or sulfur atoms etherified
C07D 333/16 - Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
C11D 1/14 - Sulfonic acids or sulfuric acid estersSalts thereof derived from aliphatic hydrocarbons or mono-alcohols
C11D 1/28 - Sulfonation products derived from fatty acids or their derivatives, e.g. esters, amides
84.
CATION EXCHANGE FOR SPERM-ASSOCIATED DNA PURIFICATION
Provided herein are methods, reagents, and kits for the isolation of sperm cells from other cell types and the purification of sperm-associated DNA from a complex sample. In particular, methods, reagents, and kits are provided for the separation of intact sperm cells from epithelial cells via binding of sperm cells to a cation exchange resin, and the extraction of sperm-associated DNA therefrom.
Provided herein are methods, reagents, and kits for the isolation of sperm cells from other cell types and the purification of sperm-associated DNA from a complex sample. In particular, methods, reagents, and kits are provided for the separation of intact sperm cells from epithelial cells via binding of sperm cells to a cation exchange resin, and the extraction of sperm-associated DNA therefrom.
Disclosed herein are compounds that can be used to selectively detect nitric oxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting nitric oxide using the compounds.
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 277/64 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
Disclosed herein are compounds that can be used to selectively detect superoxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting superoxide using the compounds.
C07D 277/68 - Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Disclosed herein are compounds that can be used to selectively detect nitric oxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting nitric oxide using the compounds.
C07D 277/68 - Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
C07C 317/28 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
C07D 307/80 - Radicals substituted by oxygen atoms
C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
Provided herein are compositions and methods for stabilizing coelenterazine and analogs or derivatives thereof, and for improving the solubility and reconstitution efficiency of coelenterazine and analogs and derivatives thereof.
Disclosed herein are compounds that can be used to selectively detect superoxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting superoxide using the compounds.
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Reagents for research purposes; reagents for non-medical purposes; Reagents for the development and manufacture of cell and gene therapy products, namely cells, nucleic acids, and viral vectors and non-viral vectors in the nature of nucleic acid carriers, each of the aforementioned for scientific and research purposes; Scientific or medical research reagents for laboratory use for providing enhanced accuracy and efficiency in vial genome titer data; Small molecule reagents for scientific or medical research use; neutralization reagents for scientific or medical research use; Reagents for use in polymerase chain reaction for scientific or medical research purposes, namely, nucleic acids, nucleotides, buffers, and enzymes; Reagents for use in sterility assays for use in drug development and production Reagents for use in medical genetic testing for providing enhanced accuracy and efficiency in vial genome titer data; Small molecule reagents for medical use; neutralization reagents for medical use; Reagents for use in polymerase chain reaction for medical genetic testing purposes, namely, nucleic acids, nucleotides, buffers, and enzymes
Provided herein are reagents and methods for incorporating modified nucleotides into DNA and detecting DNA synthesis. In particular, haloalkyl-modified nucleobases are provided for incorporation into nucleic acids for detection by bioluminescent binding agents.
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
Oplophorus luciferase-derived bioluminescent complexes, e.g., NanoBiT® bioluminescent complex, are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.
C07D 333/38 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07C 311/21 - Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 311/29 - Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 317/38 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
C07D 333/66 - Nitrogen atoms not forming part of a nitro radical
C07D 333/78 - Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Provided herein are reagents and methods for incorporating modified nucleotides into DNA and detecting DNA synthesis. In particular, haloalkyl-modified nucleobases are provided for incorporation into nucleic acids for detection by bioluminescent binding agents.
C07D 307/04 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
C07D 473/00 - Heterocyclic compounds containing purine ring systems
