The present invention relates to magnetic structures for wireless power transfers systems. In particular the invention relates to improved magnetic and ferrite layouts as well as pad designs and methods of predicting and preventing thermal failure of high-power ferrite structures. In part it relates to a wireless power transfer pad magnetic structure comprising at least two adjacent blocks are spaced apart by an inter-section spacing configured to reduce circulating flux in the layer. In part it relates to a wireless power transfer pad magnetic structure comprising a first surface configured to locate nearer a wireless power transfer coil than a second surface wherein the relative magnetic permeability of the magnetic structure increases with distance from the first surface. In part it relates to a method of preparing a magnetically permeable block for a wireless power transfer pad, the method comprising: thermally pre-cracking the magnetically permeable block.
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H01F 1/34 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
H01F 3/02 - Cores, yokes or armatures made from sheets
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
The present invention relates generally to compositions for cellular reprogramming of human somatic cells into induced neural precursor cells, methods of making induced human neural precursor cells by cellular reprogramming and methods of using reprogramed induced human neural precursor cells for treating disease.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
This invention relates to a vortex station and method for producing a vortex similar to one of a group consisting of dust-devils and waterspouts. The apparatus comprises a ground platform forming a base for the vortex station, a plurality of vanes to direct an air flow into a vortex station and about the vortex station in a substantially swirling manner, at least one wind turbine disposed near the centre of said vortex station, in a path of a concentrated air flow, wherein the movement of the air in the vortex station is such that an atmospheric buoyancy vortex is created in the centre of the vortex station, a supply of a working fluid (e.g. water) to the vortex station at or near the centre of the vortex station such that the air is of a saturated condition or an at least partially saturated condition with the working fluid (e.g. water), the working fluid (e.g. water) supplied at a sufficient quantity or amount so as to assist with maintaining buoyancy and stability of a vortex created.
F03D 9/39 - Wind motors specially adapted for installation in particular locations on stationary objects or on stationary man-made structures within towers, e.g. using chimney effects with means for enhancing the air flow within the tower, e.g. by heating by circulation or vortex formation
F03D 3/00 - Wind motors with rotation axis substantially perpendicular to the air flow entering the rotor
F03D 3/02 - Wind motors with rotation axis substantially perpendicular to the air flow entering the rotor having a plurality of rotors
A laminate for a sensor device comprises: a substrate layer laminated with an encapsulation layer; a plurality of contiguous first conduction portions arranged between the layers; a plurality of first contact portions electrically adjoining respective ones of the first conduction portions and adapted to be associated with the sensor device; a plurality of contiguous second conduction portions arranged between the layers and interdigitating with respective ones of the first conduction portions; and a plurality of second contact portions electrically adjoining respective ones of the second conduction portions and adapted to be associated with the sensor device.
G01L 1/14 - Measuring force or stress, in general by measuring variations in capacitance or inductance of electrical elements, e.g. by measuring variations of frequency of electrical oscillators
A slip connector to connect first and second members of a structure to allow relative but resisted movement, and to at least in part return any movement. In one embodiment, the connector includes a first and second components and a resilient fixing. The resilient fixing holds mutually slidable ramped surfaces of the first and second components contiguous so that the line(s) of action of the fixing(s) is/are oblique to the mutually slidable ramped surfaces held contiguous. In another embodiment the connector includes first, second and third components and a resilient fixing. The resilient fixing holds mutually slidable ramped surfaces of the first and third components contiguous and mutually slidable ramped surfaces of the second and third components contiguous so that the line(s) of action of the fixing(s) is/are oblique to the mutually slidable ramped surfaces held contiguous.
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
E04B 1/36 - Bearings or like supports allowing movement
E04B 1/38 - Connections for building structures in general
E04B 1/98 - Protection against other undesired influences or dangers against mechanical destruction, e.g. by air-raids
F16B 5/00 - Joining sheets or plates to one another or to strips or bars parallel to them
F16B 5/02 - Joining sheets or plates to one another or to strips or bars parallel to them by means of fastening members using screw-thread
A wireless power transfer resonant compensation circuit is configured to operate at a plurality of different resonant operating frequencies to form a plurality of parallel or series tuned compensation networks, each of the tuned compensation networks forming at a different resonant operating frequency.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02M 3/00 - Conversion of dc power input into dc power output
H02M 7/48 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
H02M 7/523 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only with LC-resonance circuit in the main circuit
A slip connector to connect first and second members of a structure to allow relative but resisted movement, and to at least in part return any movement. The connector includes a first component and second component, each with mutually slidable ramped surfaces contiguous. The first and second components are connectable to the respective first and second members of the structure, and there is at least one resilient fixer to hold the two components contiguous so that the line(s) of action of the fixer(s) is/are oblique to the slidable surfaces held contiguous.
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
E04B 1/36 - Bearings or like supports allowing movement
E04B 1/38 - Connections for building structures in general
E04B 1/98 - Protection against other undesired influences or dangers against mechanical destruction, e.g. by air-raids
F16B 5/00 - Joining sheets or plates to one another or to strips or bars parallel to them
F16B 5/02 - Joining sheets or plates to one another or to strips or bars parallel to them by means of fastening members using screw-thread
A wireless power transfer pad has at least one power transfer coil and a plurality of foreign object detection coils. Each foreign object detection coil is decoupled from its neighboring detection coils and is also decoupled from the power transfer coil.
H02J 50/60 - Circuit arrangements or systems for wireless supply or distribution of electric power responsive to the presence of foreign objects, e.g. detection of living beings
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
9.
DUTY CYCLE CONTROL IN POLYPHASE WIRELESS POWER TRANSFER SYSTEMS
A method of controlling a polyphase wireless power transfer coupler includes using duty cycle control to switch a polyphase converter to produce a periodic asymmetric voltage waveform across the phase windings.
H02M 7/5387 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion
H02M 7/5395 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency by pulse-width modulation
10.
INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/423 - Oxazoles condensed with carbocyclic rings
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/444 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
The invention disclosed herein relates to a rigid foam composite comprising a polyurethane and a phase change material (PCM), wherein the PCM is present in the composite at a concentration of greater than 25 weight % relative to the weight of the composite, and methods for its preparation and uses thereof.
Disclosed herein are substrates for surface-enhanced Raman spectroscopy (SERS), methods of fabrication of the same using soft and nanoparticle lithography or laser-induced nano structuring of thin films (LINST), and their use to characterize extracellular vesicles (EVs) from a range of sources including but not limited to cancers, bacteria, viruses and/or placental cells. Also disclosed are machine learning methods for classifying and/or identifying SERS spectra from particles including EVs, the machine learning methods including bottleneck classifiers or layers configured to reduce the dimension of the network. In further methods the bottleneck classifier is combined with an autoencoder in either a supervised or unsupervised manner to identify of classify SERs spectra features.
Provided are measurement devices and systems for measuring the blood oxygenation of organs and tissue. Aspects of the technology provide measurement devices and systems which combine multiple forms of spectral analysis, and multiple frequencies of light in order to allow for analysis of blood oxygenation at a range of depths within the organs and tissue.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
Disclosed in one aspect is an apparatus comprising: a conformable envelope configured to exert a constricting force corresponding to a difference between an internal pressure and a greater external pressure of the envelope; an assembly comprising a plurality of rotatably associated rotation members arranged in the envelope and configured to rotatably move away from a first assembly position and toward a second assembly position in response to the constricting force; and a first intermediate component arranged between the envelope and the assembly and configured to facilitate movement of the assembly between the first assembly position and the second assembly position.
A wireless power transfer apparatus for capacitive-inductive power transfer has a primary and a secondary device separated by the conductive member. The primary device has at least two transmitter plates configured to be capacitively coupled with the conductive member to induce a current flow and generate a magnetic field in the conductive member. The secondary device is connectable to a load and provided with a receiving coil configured to be inductively coupled with the conductive member.
A wireless power transfer system and a method of operating a multilevel converter for wireless power transfer are disclosed. The wireless power transfer system comprises a multilevel converter with stack inductors that both suppress circulating currents and replace the series inductor of a tuned LCL circuit. A zero voltage switching routine for wireless power transfer is also disclosed.
H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
17.
DEPLOYABLE BOOM MECHANISM AND APPLICATIONS THEREOF
A deployable boom mechanism, such as for a spacecraft, has a boom and a boom drum. The boom can be wound onto the boom drum. The boom drum is rotatable in a deployment direction to deploy the boom by unwinding it from the boom drum. A drive element is provided, where one end of the drive element is associated with the boom drum and is windable thereon radially outside of the boom. The other end of the drive element is associated with a drive element drum and is windable thereon. An effector is provided which is operable to rotate drive element drum and wind the drive element onto it against a bias of the boom drum, unwinding the drive element from the boom drum and rotating the boom drum in its deployment direction and deploying the boom.
B64G 4/00 - Tools specially adapted for use in space
B65H 75/34 - Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables
B64G 1/22 - Parts of, or equipment specially adapted for fitting in or to, cosmonautic vehicles
An IPT system magnetic flux pad includes two substantially planar coils (17) in close proximity to each other above a magnetically permeable core (14). The coils (17) each define a pole area (11, 12) and the distance between one or more adjacent turns of the coils (17) located in a region between the pole areas (11, 12) being different from the distance between one or more adjacent turns of the coils (17) located outside the region between the pole areas (11, 12).
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
B60L 53/126 - Methods for pairing a vehicle and a charging station, e.g. establishing a one-to-one relation between a wireless power transmitter and a wireless power receiver
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
This invention relates to a vortex station and method for producing a vortex similar to one of a group consisting of dust-devils and waterspouts. The apparatus comprises a ground platform forming a base for the vortex station, a plurality of vanes to direct an air flow into a vortex station and about the vortex station in a substantially swirling manner, at least one wind turbine disposed near the centre of said vortex station, in a path of a concentrated air flow, wherein the movement of the air in the vortex station is such that an atmospheric buoyancy vortex is created in the centre of the vortex station, a supply of a working fluid (e.g. water) to the vortex station at or near the centre of the vortex station such that the air is of a saturated condition or an at least partially saturated condition with the working fluid (e.g. water), the working fluid (e.g. water) supplied at a sufficient quantity or amount so as to assist with maintaining buoyancy and stability of a vortex created.
F03D 9/39 - Wind motors specially adapted for installation in particular locations on stationary objects or on stationary man-made structures within towers, e.g. using chimney effects with means for enhancing the air flow within the tower, e.g. by heating by circulation or vortex formation
F03D 3/00 - Wind motors with rotation axis substantially perpendicular to the air flow entering the rotor
F03D 3/02 - Wind motors with rotation axis substantially perpendicular to the air flow entering the rotor having a plurality of rotors
The present invention is a method of fabricating a flexible pressure sensor array and a sensor or sensor array. A sensor array can provide a pressure map in addition to a magnitude of pressure; hence providing tactile information of the pressure exerted on the sensor array. More particularly, the invention relates to the combination of a foam, preferably an rGO foam, and a PCB, where the PCB is preferably at the bottom, and rGO foam attaches to it. The PCB can be a typical PCB or flexible PCB. This new combination prevents resistance change of the electrodes after applying pressure. Importantly, the electrodes are all on the PCB and so all connectivity is only on one side of the sensor, providing ease of use and eliminating the electrical connection (or electrodes) exposed to physical contact with the object or load, over traditional 2-sided sensors.
G01L 1/18 - Measuring force or stress, in general using properties of piezo-resistive materials, i.e. materials of which the ohmic resistance varies according to changes in magnitude or direction of force applied to the material
B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
A method and apparatus for controlling an intermediate resonant circuit in a wireless power or IPT system includes regulating a secondary with which the intermediate circuit is magnetically coupled so as to control the VA in the intermediate resonant circuit and to control magnetic leakage fields.
An ultrasonic system (1) comprises an ultrasonic device (10) having at least one ultrasonic sound head (11) and is configure to record a 3D and/or 4D ultrasonic image of a body part. A frame (20) comprises a movable fastening position (25). The ultrasonic system further comprises at least one encoder (31; 32; 33). The ultrasonic sound head (11) is fastened at the fastening position (25) of the frame (20) in such a manner that it can be moved together with the fastening position (25). The encoder (31; 32; 33) is configured to provide position information about the current position of the movable ultrasonic sound head (11).
The present invention relates to a growth medium, which does not include cholera toxin, for culturing cells, such as epithelial cells, in particular keratinocytes, use of the medium to grow cells, (for example epithelial cells, such as keratinocytes) and kits comprising the medium. Also provided is a method of generating human full thickness skin, fully human epidermis or fully human dermis involving culturing keratinocytes and feeder cells in said cell culture medium.
A multiphase wireless power transfer pad has at least a first coil and a second coil and permeable material which includes a region of reduced magnetic permeability configured to minimise coupling between the first and second coils.
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
B60L 53/122 - Circuits or methods for driving the primary coil, i.e. supplying electric power to the coil
H01F 27/34 - Special means for preventing or reducing unwanted electric or magnetic effects, e.g. no-load losses, reactive currents, harmonics, oscillations, leakage fields
UNIVERITY OF DOHA FOR SCIENCE AND TECHNOLOGY (Qatar)
AUCKLAND UNISERVICES LIMITED (New Zealand)
Inventor
Kurdi, Jamal
Farid, Mohammed
Abstract
A method of mercury-free photochemical micro-/nano-encapsulation of an active material is a process for obtaining micro-/nano-capsules by means of curing by UV LED radiation at ambient or even cold temperatures. A stirrer photo-reactor made from glass or transparent plastics can be used but mixed flow reactor could be also employed. Appropriate mixing is sufficient to expose all droplets, which contain an active material surrounded by curable-shell materials in the emulsion to the LED radiation. Using the optimum light intensities and reactions' times is critical for encapsulating the active material with a high efficiency and producing a high quality micro-/nano- capsules, Solar monochromator device can also be used as long as it generate the same radiation with a narrow/single wavelengths as the LED device. Light emitted diode (LED) is a mercury-free UV radiation source with a long operating life time and an instant ON-Off. it has a high efficiency, a very low cooling requirements and cost-efficient in photochemical encapsulation. It reduces the time of microencapsulation from 6 hours to a less than 5 minutes. It has a significant decrease in manufacturing cost, waste-water, unconverted monomers, and leftover active phase change material (PCM) compared to other methods. Conversion of more than 90% of monomers can be achieved, and encapsulation efficiency can reach 100% at optimum conditions. This is in addition to the ability of this invented technology for encapsulate volatile and heat sensitive active materials at ambient as well as low temperatures. Normal glass or transparent plastics can be used as a reactor material. Only the matched useful wavelength radiation is emitted by LED without having other wavelengths which might have a bad impact on the encapsulation process.
B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial.
The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
The subject invention pertains to the application of GI slow-wave network analysis to profile GI side effects for applications including high-throughput drug screening on a microelectrode array (MEA) platform. Slow-wave data can be obtained, evaluated, interpreted, and used to build a comprehensive database based on the effects of specified drugs on GI pacemaker activity for predictive and classification purposes. In one example, pacemaker potentials were recorded extracellularly on a 60-channel MEA system using full-thickness GI segments isolated from Suncus murinus. Basic slow-wave parameters, including frequency, amplitude, slope, period, and power partitions, were derived. Signal regularity was also evaluated using detrended fluctuation analysis and sample entropy analysis. Signal propagation, velocity, and activation time patterns were also constructed and compared before and after treatment with dopamine (0.1-100 μM).
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
28.
HEART TISSUE IDENTIFICATION IN THE CONTEXT OF ATRIAL FIBRILLATION
A method, including obtaining heart phase data for a plurality of activation cycles of a living human afflicted with atrial fibrillation and analyzing the heart phase data to identify specific heart tissue locations where there are repeated and consistent temporal discrepancies of electrical activation relative to other tissue locations, wherein the action of analyzing the heart phase data includes executing a statistical analysis on the heart phase data.
A method of transmitting a series of 2-D images relating to a 3-D object or model between a server and a user terminal includes combining each of the 2-D images in the series of 2-D images into a single combined 2-D image, and transmitting the combined image to the user terminal.
Oxford University Innovation Limited (United Kingdom)
AUCKLAND UNISERVICES LIMITED (Azerbaijan)
Inventor
Collins, Sally
Yin, Yi
Clark, Alys
Looney, Padraig
Abstract
A computer-implemented method of automatically identifying a reference vessel in an ultrasound image, the method comprising: segmenting the image to identify an organ; locating a predetermined anatomical landmark specific to the organ; identifying appropriate vasculature for the organ; and selecting a reference vessel from the vasculature that has a size within a predetermined size range and a location with a predetermined distance range from the predetermined interface.
vwxyz(111)(200)509090 of about 1200 nm or less; submicron particles having a rod-like shape; or a particle size distribution having a standard deviation of less than about 250 nm. Also disclosed are methods for preparing an entropy stabilised oxide. Also disclosed are an electrode, e. g. an anode, a catalyst and an electrochemical cell comprising the entropy stabilised oxide.
C04B 35/453 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zinc, tin or bismuth oxides or solid solutions thereof with other oxides, e.g. zincates, stannates or bismuthates
Disclosed are high-entropy oxides, and methods of their preparation. The high- entropy oxide is characterised by a sub-micron particle size and rod-like particle shape. The method of its preparation includes a co-precipitation step, preferably using an oxalate compound as a precipitating agent. Also disclosed are an electrode, e.g. an anode, a catalyst and an electrochemical cell comprising the high-entropy oxide.
H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/382 - Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A wireless power transfer pad has at least one power transfer coil and a plurality of foreign object detection coils. Each foreign object detection coil is decoupled from its neighbouring detection coils and is also decoupled from the power transfer coil.
H01L 41/113 - Piezo-electric or electrostrictive elements with mechanical input and electrical output
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/60 - Circuit arrangements or systems for wireless supply or distribution of electric power responsive to the presence of foreign objects, e.g. detection of living beings
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
G01R 19/165 - Indicating that current or voltage is either above or below a predetermined value or within or outside a predetermined range of values
H10N 30/30 - Piezoelectric or electrostrictive devices with mechanical input and electrical output, e.g. functioning as generators or sensors
A wireless power transfer coupling apparatus, comprising: at least one conductive member configured as a layer of the first coupling member to provide a magnetic field for wireless power transfer, the conductive member having; a first end; and a second end opposite the first end, wherein: the conductive member extends from the first end to the second end along a lengthwise axis of the coupling apparatus and is configured to distribute current across the layer between the first and second ends. The conductive member comprising a layer of permeable material that extends on the either side to form pole area and further extending in a direction toward a magnetic flux coupling region. The wireless power transfer apparatus further comprising an uncompensated primary coupler and a capacitor compensated secondary that compensates the reactance of the primary coupler by a reflected impedance.
B60L 53/122 - Circuits or methods for driving the primary coil, i.e. supplying electric power to the coil
B60L 53/126 - Methods for pairing a vehicle and a charging station, e.g. establishing a one-to-one relation between a wireless power transmitter and a wireless power receiver
H01F 27/245 - Magnetic cores made from sheets, e.g. grain-oriented
H01F 27/36 - Electric or magnetic shields or screens
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
A sensor device is provided. The sensor device includes an elastic light-transmissive layer with an optical property that changes in response to deformation. First and second light sources emit respective first and second incident lights towards the skin surface of a user, with the first incident light emitted through the layer. A photodetector detects first and second reflected lights reflected from different skin depths. The sensor device may be used to detect subcutaneous tissue movements. One or more sensor devices and a model generated from sensed data, associated with different muscle states or physical positions of a user may be used to estimate a physical position or movement of a body part of a user. Such estimated physical positions or movements may be used to operate other devices such as anthropomorphic robotics, actuated exoskeletons, and active prosthetic limbs.
A sensor device is provided. The sensor device includes an elastic light-transmissive layer with an optical property that changes in response to deformation. First and second light sources emit respective first and second incident lights towards the skin surface of a user, with the first incident light emitted through the layer. A photodetector detects first and second reflected lights reflected from different skin depths. The sensor device may be used to detect subcutaneous tissue movements. One or more sensor devices and a model generated from sensed data, associated with different muscle states or physical positions of a user may be used to estimate a physical position or movement of a body part of a user. Such estimated physical positions or movements may be used to operate other devices such as anthropomorphic robotics, actuated exoskeletons, and active prosthetic limbs.
The present invention provides novels method of targeting delivery of a compound to hypoxic cells, for example treatment of diseases and disorders associated with hypoxia, comprising administration of a construct comprising a targeting carrier peptide and a compound for delivery to a hypoxic cell. The invention also provides novel methods for the treatment of diseases or disorders of the eye by administration of a novel construct, a nucleic acid encoding a novel construct, and/or a nucleic acid vector comprising a nucleic acid encoding a novel construct. The invention further provides novel constructs, nucleic acids encoding such constructs, and/or nucleic acid vectors comprising nucleic acids encoding such constructs.
A method of multispectral immunofluorescence imaging of a biological sample is described. The described method allows direct detection of seven or more target antigens simultaneously using directly labeled antibody fluorophore conjugates. The described method enables multiplex detection and analysis of a plurality of biomarkers simultaneously across an entire planar biological sample, providing unique spatio-temporal insights in immune-therapeutics and immuno-diagnostics.
The present invention relates to magnetic structures for wireless power transfers systems. In particular the invention relates to improved magnetic and ferrite layouts as well as pad designs and methods of predicting and preventing thermal failure of high-power ferrite structures. In part it relates to a wireless power transfer pad magnetic structure comprising at least two adjacent blocks are spaced apart by an inter-section spacing configured to reduce circulating flux in the layer. In part it relates to a wireless power transfer pad magnetic structure comprising a first surface configured to locate nearer a wireless power transfer coil than a second surface wherein the relative magnetic permeability of the magnetic structure increases with distance from the first surface. In part it relates to a method of preparing a magnetically permeable block for a wireless power transfer pad, the method comprising: thermally pre-cracking the magnetically permeable block.
H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
H01F 27/34 - Special means for preventing or reducing unwanted electric or magnetic effects, e.g. no-load losses, reactive currents, harmonics, oscillations, leakage fields
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H01F 27/00 - MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES - Details of transformers or inductances, in general
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
Disclosed herein are certain sets of antibody-fluorophore pairs comprising antibodies that specifically bind target antigens, the sets of antibody-fluorophore pairs thereby allowing visualization and quantification of a plurality of target antigens in a biological sample using multispectral tissue slide scanners. Also disclosed herein are methods of using such antibody-fluorophore pairs, and reagents related thereto.
A method of detecting a wirelessly powered vehicle on a roadway uses detection of induced voltages or currents in coils provided in the roadway. Once the vehicle has been detected the appropriate coils can be energised to power the vehicle.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
B60M 7/00 - Power lines or rails specially adapted for electrically-propelled vehicles of special types, e.g. suspension tramway, ropeway, underground railway
B60L 53/126 - Methods for pairing a vehicle and a charging station, e.g. establishing a one-to-one relation between a wireless power transmitter and a wireless power receiver
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
A resonant inductive power transfer circuit has a power converter to supply to a load, and the converter is concurrently controlled to create a controlled reactance that substantially compensates for variability in the coupling with the another resonant inductive power transfer circuit and/or changes in the load supplied by the power converter.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
45.
COMPOSITIONS AND METHODS FOR RESCUING RETINAL AND CHOROIDAL STRUCTURE AND FUNCTION
The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, to rescue or restore retinal function, to rescue or restore retinal structure, and/or to rescue or restore choroidal structure and/or function in chronic retinal and other disorders.
Disclosed herein are substrates for surface-enhanced Raman spectroscopy (SERS), methods of fabrication of the same using soft and nanoparticle lithography or laser-induced nano structuring of thin films (LINST), and their use to characterize extracellular vesicles (EVs) from a range of sources including but not limited to cancers, bacteria, viruses and/or placental cells. Also disclosed are machine learning methods for classifying and/or identifying SERS spectra from particles including EVs, the machine learning methods including bottleneck classifiers or layers configured to reduce the dimension of the network. In further methods the bottleneck classifier is combined with an autoencoder in either a supervised or unsupervised manner to identify of classify SERs spectra features.
G01N 21/39 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H04B 13/00 - Transmission systems characterised by the medium used for transmission, not provided for in groups
A method of operating an electric vehicle charging apparatus for a vehicle to grid interface comprising a first full bridge converter configured to convert a grid supply to a DC link and a primary full bridge converter connected to the DC link and configured to provide an output alternating current for use in vehicle charging. The method includes detecting a charging power requirement for a vehicle; determining a required voltage for the DC link to enable the converter to supply power for satisfying the charging power requirement when operating at full duty cycle; operating the primary full bridge converter at full duty cycle; controlling the voltage of the DC link to the required voltage.
H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
B60L 55/00 - Arrangements for supplying energy stored within a vehicle to a power network, i.e. vehicle-to-grid [V2G] arrangements
H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H02J 3/36 - Arrangements for transfer of electric power between ac networks via a high-tension dc link
The invention disclosed herein relates to a rigid foam composite comprising a polyurethane and a phase change material (PCM), wherein the PCM is present in the composite at a concentration of greater than 25 weight % relative to the weight of the composite, and methods for its preparation and uses thereof.
A method of controlling the primary or secondary side converter of a wireless power transfer (WPT) or an inductive power transfer (IPT) system includes optimising a load impedance, and controlling one or more of a duty cycle or relative phase angle to reduce or minimize the converter losses at the optimal load impedance
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion
The inventions relate to the use of hemichannel blockers to modulate cytokine levels in a subject, including the angiogenic cytokine, VEGF, and their production, secretion and/or release, and to the use of hemichannel blockers to reduce or level cytokine activity, including in conditions characterized in whole or in part by angiogenesis and/or vessel leak.
UNIVERSITY OF DOHA FOR SCIENCE & TECHNOLOGY (Qatar)
AUCKLAND UNISERVICES LIMITED (New Zealand)
Inventor
Kurdi, Jamal
Farid, Mohammed
Abstract
A method of mercury-free photochemical micro-/nano-encapsulation of an active material is a process for obtaining Micro-/nano-capsules by means of curing by UV LED radiation at ambient or even cold temperatures. A stirrer photo-reactor made from glass or transparent plastics can be used but mixed flow reactor could be also employed. Appropriate mixing is sufficient to expose all droplets, which contain an active material surrounded by curable-shell materials in the emulsion to the LED radiation. Using the optimum light intensities and reactions' times is critical for encapsulating the active material with a high efficiency and producing a high quality micro-/nano-capsules, Solar monochromator device can also be used as long as it generate the same radiation with a narrow/single wavelengths as the LED device. Light emitted diode (LED) is a mercury-free UV radiation source with a long operating life time and an instant ON-Off, it has a high efficiency, a very low cooling requirements and cost-efficient in photochemical encapsulation. It reduces the time of microencapsulation from 6 hours to a less than 5 minutes. It has a significant decrease in manufacturing cost, waste-water, unconverted monomers, and leftover active phase change material (PCM) compared to other methods. Conversion of more than 90% of monomers can be achieved, and encapsulation efficiency can reach 100% at optimum conditions. This is in addition to the ability of this invented technology for encapsulate volatile and heat sensitive active materials at ambient as well as low temperatures. Normal glass or transparent plastics can be used as a reactor material. Only the matched useful wavelength radiation is emitted by LED without having other wavelengths which might have a bad impact on the encapsulation process.
B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
A gear arrangement for actuating the fingers of a grasping device is disclosed. The gear arrangement distributes torque and/or rotational motion from a drive interface, such as an input gear or pulley, to three or more output shafts that are axially aligned. The gear arrangements can distribute torque and/or rotational motion to two output shafts that are axially aligned and co-extensive. These gear arrangements can utilise nested differentials, where the output from an outer differential is used as input to one or more inner differentials. The output from the differential is coupled to the fingers of a grasping device by a network of artificial tendons.
The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, inhibitors and blockers, to modulate, suppress and stabilize epithelial-mesenchymal and/or endothelial-mesenchymal transition in diseases, disorders and conditions, including fibrotic diseases, disorders and conditions and other conditions associated with fibrosis.
A61K 9/00 - Medicinal preparations characterised by special physical form
C07D 311/68 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
55.
COMPOSITIONS AND METHODS FOR MODULATING EPITHELIAL-MESENCHYMAL TRANSITION
The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, inhibitors and blockers, to modulate, suppress and stabilize epithelial-mesenchymal and/or endothelial-mesenchymal transition in diseases, disorders and conditions, including fibrotic diseases, disorders and conditions and other conditions associated with fibrosis.
A61K 9/00 - Medicinal preparations characterised by special physical form
C07D 311/68 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
A method of charging a battery includes coupling an electricity network or subnetwork to the battery using inductive power transfer, transferring electrical energy to the battery from the electricity network or subnetwork and varying the inductive power transfer using a controller of the electricity network or subnetwork according to at least one predetermined criteria of the electricity network or subnetwork.
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
B60L 8/00 - Electric propulsion with power supply from forces of nature, e.g. sun or wind
B60L 53/10 - Methods of charging batteries, specially adapted for electric vehicles; Charging stations or on-board charging equipment therefor; Exchange of energy storage elements in electric vehicles characterised by the energy transfer between the charging station and the vehicle
B60L 53/124 - Detection or removal of foreign bodies
B60L 53/126 - Methods for pairing a vehicle and a charging station, e.g. establishing a one-to-one relation between a wireless power transmitter and a wireless power receiver
B60L 53/30 - Constructional details of charging stations
B60L 53/38 - Means for automatic or assisted adjustment of the relative position of charging devices and vehicles specially adapted for charging by inductive energy transfer
H02J 7/14 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from dynamo-electric generators driven at varying speed, e.g. on vehicle
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
57.
WIRELESS POWER REGULATION AND CONTROL USING A RESONANT INTERMEDIATE COIL
A method and apparatus for controlling an intermediate resonant circuit in a wireless power or IPT system includes regulating a secondary with which the intermediate circuit is magnetically coupled so as to control the VA in the intermediate resonant circuit and to control magnetic leakage fields.
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion
H01F 27/00 - MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES - Details of transformers or inductances, in general
58.
DUTY CYCLE CONTROL IN POLYPHASE WIRELESS POWER TRANSFER SYSTEMS
A method of controlling a polyphase wireless power transfer coupler includes using duty cycle control to switch a polyphase converter to produce a periodic asymmetric voltage waveform across the phase windings.
H02M 7/5387 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
H02M 7/5395 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency by pulse-width modulation
H02M 7/501 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode sinusoidal output voltages being obtained by the combination of several pulse-voltages having different amplitude and width
H02M 7/48 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
H02M 7/527 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only with automatic control of output waveform or frequency by pulse width modulation
An open catheter has at least eight splines making up a basket. Each of the splines includes at least six electrodes. An arm is provided connected to and capable of moving the splines from a closed position to an open position, and multiple positions therebetween.
There is provided a fixation device to secure a catheter tube. The fixation device comprises a body with a proximal surface and a distal surface, a first opening in the proximal surface, a second opening in the distal surface, and a sidewall that connects the first opening and the second opening to form a through-hole. The body is configured to receive a first portion of the catheter tube. The fixation device further comprises a retainer configured to retain the first portion of the catheter tube in the channel. The body is configured such that the catheter tube extends in use from the body through the through-hole to an exit point at which a second portion of the catheter tube exits the patient's skin. The body is configured such that the sidewall is in use spaced from the exit point to create a window to a region of the patient's skin.
Optimising water use in a way that avoids over watering or at least avoids or minimises water mobilisation may be useful. An irrigation control system is described, the system including a sound emitter arranged to emit sound towards a ground surface; a sound receiver arranged to receive sound emitted by the sound emitter and reflected or scattered from the ground surface. A controller then controls one or more irrigation parameters of an irrigator based at least in part on sound received by the sound receiver. In a further aspect, the irrigation control system senses the onset of surface water pooling or free water flow on the ground surface and the controller then controls irrigation parameters to reduce application of water in response to the sensed features. Related methods of controlling irrigation systems are also described.
A wireless power transfer system and a method of operating a multilevel converter for wireless power transfer are disclosed. The wireless power transfer system comprises a multilevel converter with stack inductors that both suppress circulating currents and replace the series inductor of a tuned LCL circuit. A zero voltage switching routine for wireless power transfer is also disclosed.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02M 7/483 - Converters with outputs that each can have more than two voltage levels
H02M 7/501 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode sinusoidal output voltages being obtained by the combination of several pulse-voltages having different amplitude and width
H02M 7/5395 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency by pulse-width modulation
H02M 7/54 - Conversion of dc power input into ac power output without possibility of reversal by dynamic converters
The present invention relates to pharmaceutical formulations comprising a lipase inhibitor and long-chain fatty acids. The formulation enables the lipase inhibitor to be delivered to the intestinal lymph and are thereby useful in the treatment or prevention of diseases and conditions mediated by pancreatic lipase, such as acute pancreatitis and associated syndromes.
The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
The invention relates to 2-methylbenzoxazole compounds of formula I which are analogues of the DNA alkylating subunit of the duocarmycins. Compounds of formula I can be used in the synthesis of DNA alkylating agents and antibody-drug conjugates and related compounds. The 2-methylbenzoxaxole unit of formula I has advantageous properties in combining high cytotoxicity, low lipophilicity, and unusual aqueous stability, all of which are desirable for application as payloads in efficacious antibody-drug conjugates.
The invention relates to 2-methylbenzoxazole compounds of formula I which are analogues of the DNA alkylating subunit of the duocarmycins. Compounds of formula I can be used in the synthesis of DNA alkylating agents and antibody-drug conjugates and related compounds. The 2-methylbenzoxaxole unit of formula I has advantageous properties in combining high cytotoxicity, low lipophilicity, and unusual aqueous stability, all of which are desirable for application as payloads in efficacious antibody-drug conjugates.
C07D 498/02 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
A61K 31/424 - Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
66.
NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER
The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
The present invention relates to biocompatible compositions comprising one or more crystallin proteins, and the use of such compositions in therapeutic and research methods, for example in surgical methods, in sustained release drug delivery, and in cell-based methods.
Data representative of the eye obtained from multiple modalities are combined into a virtual model of the eye. The multiple modalities indicate anatomical, physiological, and/or functional features of the eye. The data from different modalities is registered in order to combine the data into the virtual model. Eye data can be analyzed in the form of the virtual model. Neural networks can be used to obtain insights about medical conditions of the eye, such as for diagnosis or prognosis of conditions. It can also be predicted how the eye will respond to certain treatments.
A wireless coupling structure has a first layer comprising a flux coupling coil having two opposing end regions separated by two opposing side regions; a second layer comprising a first block of ferrite and a second block of ferrite; and a third layer comprising a leakage flux control coil. The first block is provided next to one of the end regions and the second block is provided next to the other of the end regions.
H01F 27/36 - Electric or magnetic shields or screens
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
OXFORD UNIVERSITY INNOVATION LIMITED (United Kingdom)
AUCKLAND UNISERVICES LIMITED (New Zealand)
Inventor
Collins, Sally
Yin, Yi
Clark, Alys
Looney, Padraig
Abstract
A computer-implemented method of automatically identifying a reference vessel in an ultrasound image, the method comprising: segmenting the image to identify an organ; locating a predetermined anatomical landmark specific to the organ; identifying appropriate vasculature for the organ; and selecting a reference vessel from the vasculature that has a size within a predetermined size range and a location with a predetermined distance range from the predetermined interface.
and each coupler module is linked with at least one other coupler module at a shared one switching element of the corresponding pair of switching elements. A control module is configured to effect control between the active state and the passive state by controlling the phase angle of the corresponding pair of switching elements.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
B60L 53/122 - Circuits or methods for driving the primary coil, i.e. supplying electric power to the coil
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H04B 5/00 - Near-field transmission systems, e.g. inductive loop type
An inductive power transfer system primary or secondary circuit has a first compensation network and second compensation network. The compensation networks each have a different power transfer characteristic with respect to relative movement of the primary or secondary magnetic flux coupling structures. The power transfer characteristics are such that one compensates for the other to allow a smooth or constant overall power transfer is despite the relative movement.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02M 3/337 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only in push-pull configuration
73.
INDUCTIVE POWER AND DATA TRANSFER USING ENERGY INJECTION
A wireless power transfer secondary or pick-up has a resonant circuit and a switch connected to the resonant circuit operable to produce a phase shift in an oscillating voltage or current in the resonant circuit. A controller is configured to operate the switch to introduce one or more controlled phase shifts in the oscillating voltage or current in the resonant circuit which encode data for detection by a coupled circuit.
An IPT track arrangement including a power supply and conductor electrically connected to the power supply, the conductor includes a plurality of loops located substantially adjacent one another, wherein the polarity in adjacent portions of the loops is the same, and wherein the power supply includes a one or more inverters which share the track load.
H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
B60L 53/30 - Constructional details of charging stations
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
75.
MULTIPLEX IMMUNOFLUORESCENCE DETECTION OF TARGET ANTIGENS
A method of multispectral immunofluorescence imaging of a biological sample is described. The described method allows direct detection of seven or more target antigens simultaneously using directly labelled antibody fluorophore conjugates. The described method enables multiplex detection and analysis of a plurality of biomarkers simultaneously across an entire planar biological sample, providing unique spatio-temporal insights in immune-therapeutics and immuno-diagnostics.
A method of multispectral immunofluorescence imaging of a biological sample is described. The described method allows direct detection of seven or more target antigens simultaneously using directly labelled antibody fluorophore conjugates. The described method enables multiplex detection and analysis of a plurality of biomarkers simultaneously across an entire planar biological sample, providing unique spatio-temporal insights in immune-therapeutics and immuno-diagnostics.
A pressure sensor apparatus includes a plurality of pressure responsive chambers provided along a longitudinal dimension of the apparatus, and a pressure sensor device provided in each chamber which together provide a pressure profile in an anatomical cavity.
The present invention relates to selective presenilin-2 γ-secretase inhibitors for use in the treatment of various diseases associated with a defect leading to Notch receptor hyperactivity. In particular the present invention relates to selective presenilin-2 γ-secretase inhibitors for use as a highly selective anti-cancer treatment. Preferred selective presenilin-2 γ-secretase inhibitors include small molecules, like 4-aminoquinolines or imidazole compounds, (monoclonal) antibodies and known γ-secretase inhibitors or analogues and combinations thereof.
A resonant inductive power transfer circuit has a power converter to supply to a load, and the converter is concurrently controlled to create a controlled reactance that substantially compensates for variability in the coupling with the another resonant inductive power transfer circuit and / or changes in the load supplied by the power converter.
H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion
H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
H02J 5/00 - Circuit arrangements for transfer of electric power between ac networks and dc networks
This disclosure relates to wireless power transfer using conductive or conductive/capacitive techniques or systems. It also relates to implantable medical devices, and in particular to energy transfer to these devices or implants by transferring power through human or animal tissues. A wireless power transfer system that employs a form of conductively coupled power transfer to transfer energy to deeply implanted devices. Embodiments of this invention are directed to a medical device implant having an electrically conductive housing or casing part which comprises an electrode of a wireless power receiver wherein the electrode receives power by conducting current from surrounding tissue; a wireless power transfer system comprising: a transmitter means configured to provide an electric field to body tissue, and a receiver means having first and second electrodes configured to receive current through the body tissue; a wireless power system primary apparatus comprising a first electrode and a second electrode in opposed relationship to the first electrodes, the electrodes being configured to apply an electromotive force to body tissue interposed between the electrodes; and a method of wireless power transfer comprising receiving power at a receiver device implanted in body tissue from current conducted through the body tissue.
The disclosure provides a wireless power transfer circuit that uses two coupled resonators provided in one of a primary or secondary wireless power transfer magnetic structure. The coupled resonators work together to compensate for changes in relative position. Each resonator has a planar coil, and the resonators are coupled with each other by magnetic coupling of the planar coils, which are located adjacent each other in either a side by side relationship or a partially overlapping relationship. The circuit is tolerant to misalignment of the magnetic structures (often referred to as pads) which magnetically couple with each other to enable the transfer of power. The changes in inductances as well as main, cross, and inter coupling between the coils of the primary and pick-up pads or structures show that a constant power transfer or charging profile can be maintained over a large operating region.
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 31/444 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 31/423 - Oxazoles condensed with carbocyclic rings
A roadway powered electric vehicle system includes a power supply (101) which makes power available inductively to one or more modules (111) provided in or under a roadway. Modules (111) make a magnetic field selectively available to one or more vehicles travelling over the roadway corresponding to the location of the vehicle. The presence or strength of the magnetic field provided on the roadway may be dependent upon the vehicle type or category.
B60L 53/126 - Methods for pairing a vehicle and a charging station, e.g. establishing a one-to-one relation between a wireless power transmitter and a wireless power receiver
B60L 53/122 - Circuits or methods for driving the primary coil, i.e. supplying electric power to the coil
B60L 5/00 - Current-collectors for power supply lines of electrically-propelled vehicles
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/382 - Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
The present invention provides novels method of targeting delivery of a compound to hypoxic cells, for example treatment of diseases and disorders associated with hypoxia, comprising administration of a construct comprising a targeting carrier peptide and a compound for delivery to a hypoxic cell. The invention also provides novel methods for the treatment of diseases or disorders of the eye by administration of a novel construct, a nucleic acid encoding a novel construct, and/or a nucleic acid vector comprising a nucleic acid encoding a novel construct. The invention further provides novel constructs, nucleic acids encoding such constructs, and/or nucleic acid vectors comprising nucleic acids encoding such constructs.
THE QUEEN'S UNIVERSITY OF BELFAST (United Kingdom)
AUCKLAND UNISERVICES LIMITED (New Zealand)
Inventor
Jones, David
Andrews, Gavin
Svirskis, Darren
Hill, Andrew
Bhusal, Prabhat
Sharma, Manisha
Agarwal, Priyanka
Li, Shu
Abstract
The invention provides a device comprising: at least one biocompatible polymer; and an eutectic composition comprising a first agent and an agent capable of forming a eutectic composition with the first agent; or one or more fatty acids; or one or more fatty alcohols; or one or more fatty amines or combinations thereof. The device can be administered to a subject in need thereof an effective amount of one or more active agents. The at least one biocompatible polymer may be selected from the group comprising poly ethylene-vinyl-acetate, vinyl acetate, silicone, polycaprolactone, polylacticco-glycolic acid, polylactic acid or polyglycolic acid.
A61K 47/12 - Carboxylic acids; Salts or anhydrides thereof
A61K 47/18 - Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, to rescue or restore retinal function, to rescue or restore retinal structure, and/or to rescue or restore choroidal structure and/or function in chronic retinal and other disorders.
A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
C07D 311/68 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
88.
COMPOSITIONS AND METHODS FOR RESCUING RETINAL AND CHOROIDAL STRUCTURE AND FUNCTION
The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, to rescue or restore retinal function, to rescue or restore retinal structure, and/or to rescue or restore choroidal structure and/or function in chronic retinal and other disorders.
A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
C07D 311/68 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
A method of controlling the primary or secondary side converter of a wireless power transfer (WPT) or an inductive power transfer (IPT) system includes optimising a load impedance, and controlling one or more of a duty cycle or relative phase angle to reduce or minimize the converter losses at the optimal load impedance
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
H02M 3/22 - Conversion of dc power input into dc power output with intermediate conversion into ac
A method of operating an electric vehicle charging apparatus for a vehicle to grid interface comprising a first full bridge converter configured to convert a grid supply to a DC link and a primary full bridge converter connected to the DC link and configured to provide an output alternating current for use in vehicle charging. The method includes detecting a charging power requirement for a vehicle; determining a required voltage for the DC link to enable the converter to supply power for satisfying the charging power requirement when operating at full duty cycle; operating the primary full bridge converter at full duty cycle; controlling the voltage of the DC link to the required voltage.
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
The present disclosure relates to a boost active bridge converter, which has particular, but not sole, relevance to a converter for an inductive or capacitive (wireless) power transfer system. According to an embodiment An AC-AC converter is presented. The AC-AC converter comprises a bridge circuit including at least two half-bridge converters, each half bridge converter comprising a first switch at an upper end and a second switch at a lower end, a capacitor connected to each half-bridge converter, the half bridge converters being connected to each other between the respective first switches and second switches thereof, the upper ends of each half bridge converters being connectable to a primary energy source, wherein the converter is operable to provide a controllable AC output.
H02M 5/458 - Conversion of ac power input into ac power output, e.g. for change of voltage, for change of frequency, for change of number of phases with intermediate conversion into dc by static converters using discharge tubes or semiconductor devices to convert the intermediate dc into ac using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
The present disclosure relates to an integrated boost modular multilevel converter, which has particular, but not sole, relevance to a converter for an inductive or capacitive (wireless) power transfer system. More particularly, the present invention according to an embodiment discloses a modular multilevel power converter (MMPC) comprising: at least one submodule stack having an output for connection to a load and an input for connection to an input power source, at least one inductive element provided between the input and the output, the at least one submodule stack including at least two submodules, each submodule comprising at least one capacitor and a plurality of controllable switches, and the submodules being operable to selectively transfer energy from the at least one inductive element to boost a voltage at the output relative to a voltage at the input.
H02M 7/483 - Converters with outputs that each can have more than two voltage levels
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
H02M 1/12 - Arrangements for reducing harmonics from ac input or output
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters
93.
Flexible switches affected by lateral or vertical actuation
A flexible switch has a deformable body and a plurality of electrodes, at least one of the electrodes being provided on the deformable body. The switch has a first state in which the electrodes are spaced apart and a second state in which the electrodes are in electrical contact, and the switch is configured to allow movement between the states when a force is applied to or removed from the deformable body.
H01H 13/79 - Switches having rectilinearly-movable operating part or parts adapted for pushing or pulling in one direction only, e.g. push-button switch having a plurality of operating members associated with different sets of contacts, e.g. keyboard characterised by the contacts or the contact sites characterised by the form of the contacts, e.g. interspersed fingers or helical networks
H01H 13/80 - Switches having rectilinearly-movable operating part or parts adapted for pushing or pulling in one direction only, e.g. push-button switch having a plurality of operating members associated with different sets of contacts, e.g. keyboard characterised by the contacts or the contact sites characterised by the manner of cooperation of the contacts, e.g. with both contacts movable or with bounceless contacts
H01H 1/14 - Contacts characterised by the manner in which co-operating contacts engage by abutting
A gear arrangement for actuating the fingers of a grasping device is disclosed. The gear arrangement distributes torque and/or rotational motion from a drive interface, such as an input gear or pulley, to three or more output shafts that are axially aligned. The gear arrangements can distribute torque and/or rotational motion to two output shafts that are axially aligned and co-extensive. These gear arrangements can utilise nested differentials, where the output from an outer differential is used as input to one or more inner differentials. The output from the differential is coupled to the fingers of a grasping device by a network of artificial tendons.
A wireless power transfer apparatus for capacitive-inductive power transfer has a primary and a secondary device separated by the conductive member. The primary device has at least two transmitter plates configured to be capacitively coupled with the conductive member to induce a current flow and generate a magnetic field in the conductive member. The secondary device is connectable to a load and provided with a receiving coil configured to be inductively coupled with the conductive member.
The inventions relate to the use of hemichannel blockers to modulate BRB integrity and function, RPE integrity and function, tight junction integrity and function, ZO-1 internalization, gap junction internalization, and/or type IV collagen levels in a subject.
The present invention provides a multi-coil inductive power transfer primary comprising a plurality of coil. A power transfer regime is selected based on a determined load on each of the plurality of coils.
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
98.
PEPTIDE CONJUGATE AMYLIN AGONISTS AND USES THEREOF
Disclosed are peptide conjugates that are amylin agonists comprising an amylin peptide comprising or consisting of an amino acid sequence that is an analogue of SEQ ID NO: 1, wherein the peptide comprises a proline residue at positions 25, 28 and 29, wherein at least one amino acid of the peptide is covalently conjugated to a lipid-containing moiety via a sulfur atom of a sulfhydryl group. Also disclosed are pharmaceutical compositions and kits comprising such conjugates, methods of preparing such conjugates, and methods and uses of such agonists.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
An open catheter has at least eight splines making up a basket. Each of the splines includes at least six electrodes. An arm is provided connected to and capable of moving the splines from a closed position to an open position, and multiple positions therebetween.
A61B 5/042 - Electrodes specially adapted therefor for introducing into the body
A61B 5/02 - Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
The inventions relate to the use of hemichannel blockers to modulate BRB integrity and function, RPE integrity and function, tight junction integrity and function, ZO-1 internalization, gap junction internalization, and/or type IV collagen levels in a subject.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
