A computer-implemented method for classifying cancer uses image analysis software to analyze a digital histology image of tumour cells of a patient. The image analysis software is trained to segment tissue regions, identify nuclei, and measure nuclear features of a plurality of nuclei. Summary statistics for nuclear feature values are obtained and one or multiple prognostic classifiers are applied to the patient's nuclear feature values to produce a prognostic score for the patient from the prognostic classifiers. The prognostic score may be for recurrence-free survival of the patient or may discriminate between high-grade and low-grade tumours.
G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
G06V 10/77 - Processing image or video features in feature spacesArrangements for image or video recognition or understanding using pattern recognition or machine learning using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]Blind source separation
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Downloadable business education software; downloadable course materials in the in the field of business education; downloadable podcasts; downloadable videos in the field of business education; electronic books.
(2) Academic year planners; books; brochures; calendars; newsletters; printed instructor materials, namely, course syllabuses; printed course materials in the field of business education; stickers. (1) Education in the fields of accounting, business analytics, business management, business strategy, commerce, finance, human resources, leadership, marketing; operation of an educational institution at the university level; providing non-downloadable course materials in the field of business education; providing non-downloadable podcasts in the field of business education; providing non-downloadable videos in the field of business education; providing online non-downloadable instructor materials, namely, course syllabuses.
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Downloadable business education software; downloadable course materials in the in the field of business education; downloadable podcasts; downloadable videos in the field of business education; electronic books.
(2) Academic year planners; books; brochures; calendars; newsletters; printed instructor materials, namely, course syllabuses; printed course materials in the field of business education; stickers. (1) Education in the fields of accounting, business analytics, business management, business strategy, commerce, finance, human resources, leadership, marketing; operation of an educational institution at the university level; providing non-downloadable course materials in the field of business education; providing non-downloadable podcasts in the field of business education; providing non-downloadable videos in the field of business education; providing online non-downloadable instructor materials, namely, course syllabuses.
5.
Peptide-Protected Gold Nanocluster and Uses Thereof
A gold nanocluster of the formula Au22(Lys-Cys-Lys)16, wherein Lys-Cys-Lys is lysine-cysteine-lysine, and methods for synthesis, are provided. The gold nanocluster effectively produces Type I ROS and functions as photosensitizer, and has utility in applications such as, but not limited to, biomedical applications and photocatalysis. The gold nanocluster may be useful in photodynamic therapy (PDT) and as a radiosensitizer in cells and tissues for treating diseases such as certain cancers.
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A multi-source inverter (MSI) topology features significant advantages over conventional MSI converters such as NPC-based and T-Type-based topologies, including a lower number of switching devices, higher efficiency, and better thermal distribution of switching devices. A space vector modulation (SVM) scheme for MSI topologies presented herein and for conventional MSI topologies uses three or four adjacent vectors to generate a reference voltage vector, resulting in lower voltage and current total harmonic distortion (THD) at the MSI output, a lower switching frequency, and increased efficiency relative to conventional MSI modulation. Embodiments are suitable for use in electric vehicles and energy storage systems.
H02M 7/539 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency
B60L 15/00 - Methods, circuits or devices for controlling the propulsion of electrically-propelled vehicles, e.g. their traction-motor speed, to achieve a desired performanceAdaptation of control equipment on electrically-propelled vehicles for remote actuation from a stationary place, from alternative parts of the vehicle or from alternative vehicles of the same vehicle train
Compounds and pharmaceutical compositions include inhibitors of apoptosis inducing factor (AIF). Pharmaceutical compositions for the treatment and/or mitigation of diseases in which increased rates of apoptosis are part of the disease pathophysiology, particularly, but not exclusively, when levels or activities of AIF are increased.
C07C 43/225 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
C07D 209/88 - CarbazolesHydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C07D 277/64 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
8.
METHODS AND DEVICES FOR PREPARING AND ANALYZING EMBEDDED TISSUES
A device for preparing a tissue for analysis includes a first conduit adapted to transport at least one solvent, the first conduit having a distal opening that delivers the at least one solvent to a selected location on the tissue, a second conduit adapted to collect a sample comprising the at least one solvent and an analyte/metabolite from the tissue and transport the sample to at least one of a waste disposal, a storage container, and a sample analyzer. The device may be configured to directly sample an embedded tissue, and may include a heater that heats the at least one solvent to a temperature that melts the embedding medium, wherein the collected sample comprises the at least one solvent, liquified embedding medium, and an analyte/metabolite. The device allows direct analysis of the tissue at the selected location, without removing the embedding medium from the entire tissue section.
The present application provides stable, mesoionic carbene-functionalized self-assembled monolayers on substrate surfaces, and methods and uses thereof. These monolayers bond to metallic surfaces and are more stable than thiol- functionalized coatings. Uses of such mesoionic carbene-functionalized coatings include primers for protecting metal surfaces, protection of metals in microelectronic devices, drug delivery or sensing applications.
B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
C07F 17/02 - Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
C23C 22/02 - Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using non-aqueous solutions
A photoacoustic system for tissue-conserving surgery includes a photoacoustic transmitter, an acoustic receiver arranged to receive acoustic energy from a photoacoustic source generated within a surgical region of a patient by the photoacoustic transmitter, and a data processor configured to communicate with the acoustic receiver. The photoacoustic transmitter is configured to be insertable into a resection cavity of the surgical region of the patient during the tissue-conserving surgery. The photoacoustic transmitter includes a light source that emits light that is absorbed more strongly by a contrast agent than surrounding tissue, the contrast agent being suitable to selectively concentrate more in cancerous tissue than in healthy tissue, and the processor is further configured to provide a location of the photoacoustic source when generated in at least a portion of the contrast agent by the photoacoustic transmitter.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A composition includes at least one tumour antigen comprising dead infected tumour cells that were infected and incubated with a non-oncolytic virus prior to cell death and a pharmaceutically acceptable vehicle. The at least one tumour antigen may be a tumour associated antigen (TAA), at least one tumour specific antigen (TSA), or a combination thereof. The composition may be used as a cancer vaccine, a prophylactic cancer vaccine, or as a therapeutic cancer treatment, wherein the composition prevents, inhibits, or slows tumour development.
An actuator includes a motor operable in first and second opposite actuation directions, a member that is driven by the motor during at least the first actuation direction, and a clutch mechanism. A force generated by the motor in the first actuation direction engages the clutch with the driving member and the force is transferred to the driving member. The driving member is maintained in position against a back-driving force by the clutch when the motor is actuated in the first direction and the driving member is back-drivable when the clutch is disengaged. The actuator may be modular and an actuator system may include two or more of the actuators and a controller that implements a control strategy to control speed and/or power of the system output by one or more of recruiting individual actuators, controlling actuation frequency of the actuators, and controlling timing of actuation of recruited actuators.
Her Majesty the Queen in Right of Canada, Minister of the Department of National Defence (DND) (Canada)
Inventor
Weber, Kela P.
Turner, Lauren
Battye, Nick
Kueper, Bernard
Hendry, Andrew Jason
Abstract
A method for remediating PFAS-contaminated soil comprises measuring the initial moisture content of the PFAS-contaminated soil, optionally drying the PFAS-contaminated soil, and ball milling the PFAS-contaminated soil with or without the use of milling additives.
A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.
A gold nanocluster of the formula Au16(RGDC)14, wherein RGDC is arginine-glycine-aspartic acid-cysteine, and methods for synthesis, are described. The gold nanocluster effectively produces Type I ROS and functions as photosensitizer, and has utility in applications such as, but not limited to, biomedical applications and photocatalysis. The gold nanocluster may be useful in photodynamic therapy (PDT) in cells and tissues for treating diseases such as certain cancers.
A method for scheduling actions of agents in a fleet disposed in an environment comprises using data from sensors on one agent and a Q-learning algorithm to compute initial Q-values for the agent during an exploration period comprising a selected number of actions of the agent. After each action is completed a reward is calculated and used to update a Q-value of a corresponding action-state. An optimized set of Q-values for the one agent is obtained after the exploration period, and the optimized set of Q-values is applied to all the agents in the fleet. Sensor data from the agents is used to further update Q-values for agents on an ongoing basis. The environment may be, e.g., a factory, industry, processing plant, mine, construction site, military operation, or a disaster zone.
G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
E21F 17/00 - Methods or devices for use in mines or tunnels, not covered elsewhere
G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
H04W 4/38 - Services specially adapted for particular environments, situations or purposes for collecting sensor information
17.
WATER-SOLUBLE N-HETEROCYCLIC CARBENE METAL NANOCLUSTERS
NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (Japan)
Inventor
Sullivan, Angus
Crudden, Cathleen M.
Kulkarni, Viveka
Laluk, Andrew
Handel, Florian
Man, Renee
Masakazu, Nambo
Yi, Hong
Capicciotti, Chantelle
Abstract
Water-soluble nanoclusters that include gold, and a bisTV-heterocyclic carbene ligand that includes at least one water soluble moiety are described. The water soluble moiety comprises a polyether, a carboxylic acid, a carboxylate, an ammonium group, a sugar, or a protein. The water soluble moiety is located on the wingtips of the bisNHC ligands or the water soluble moiety is located on the backbone of the bisNHC ligands. The nanocluster may further comprise a targeting ligand such as a derivative of folic acid, or the metal nanocluster may further comprise at least one clickable group such as an azide. As described herein, the water-soluble Atir, nanoclustcrs protected by NHC ligands have been synthesized and characterized. Their water solubility properties aid in biomedical testing and application of this material. Applications for the nanoclusters include photosensitizing and cell imaging due to the properties of luminescence when exposed to radiation.
B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
C07D 403/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01D 5/26 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light
G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
G01R 33/28 - Details of apparatus provided for in groups
H10K 30/35 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains comprising inorganic nanostructures, e.g. CdSe nanoparticles
The present disclosure provides compounds and pharmaceutically acceptable salts thereof for inhibiting CYP26B1. Aspects of the present disclosure also include methods of using the compounds to treat diseases or disorders, including, but not limited to, skin disorders, cancer, neurological disorders, heterotopic ossification (HO), fibrodysplasia ossificans progressiva (FOP), multiple osteochondromas, and diseases or disorders of the eye, including meibomian gland dysfunction and dry eye disease.
C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
A61K 31/422 - Oxazoles not condensed and containing further heterocyclic rings
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
C07D 209/10 - IndolesHydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
C07D 209/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 235/08 - Radicals containing only hydrogen and carbon atoms
C07D 307/79 - Benzo [b] furansHydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
The present disclosure provides compounds and pharmaceutically acceptable salts thereof for inhibiting CYP26B1. Aspects of the present disclosure also include methods of using the compounds to treat diseases or disorders, including, but not limited to, skin disorders, cancer, neurological disorders, heterotopic ossification (HO), fibrodysplasia ossificans progressiva (FOP), multiple osteochondromas, and diseases or disorders of the eye, including meibomian gland dysfunction and dry eye disease.
C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
A61K 31/423 - Oxazoles condensed with carbocyclic rings
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
A61K 31/428 - Thiazoles condensed with carbocyclic rings
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
C07D 209/10 - IndolesHydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
C07D 209/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 277/66 - Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
C07D 333/54 - Benzo [b] thiophenesHydrogenated benzo [b] thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 405/10 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (Japan)
Inventor
Albright, Emily Lauren
Crudden, Cathleen M.
Levchenko, Tetyana
Masakazu, Nambo
Yi, Hong
Abstract
Luminescent homometallic and heterometallic nanoclusters that include ditopic ligands with at least one N-heterocyclic carbene are presented. High photoluminescence quantum yields are reported, including one at 68%. These nanoclusters are thermally stable and are suitable for imaging, as photosensitizers, photosensors, and for photodynamic or X- ray photodynamic therapy..
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
C07F 19/00 - Metal compounds according to more than one of main groups
Rapid calibration of a quantitative analysis instrument such as a mass spectrometer is performed using a calibration chip surface having different sized surface energy traps (SETs) and a transfer chip surface having same sized SETs, wherein the SETs of each chip surface are substantially aligned when they are disposed face to face. The calibration chip is exposed to an analyte solution 5 such that different sized droplets adhere to the different sized SETs, and the transfer chip is exposed to a standard solution such that same sized droplets adhere to the same sized SETs. The chips are aligned face to face in a spaced relationship such that at least a portion of each droplet of the standard solution is transferred to the SETs of the calibration chip. The chips are then separated and the calibration chip is used to calibrate the quantitative analysis instrument by sampling the SETs.
H01J 49/00 - Particle spectrometers or separator tubes
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
22.
Adhesive Wearable Sensors for Measuring Bioelectrical Signals
A sensor for recording bioelectrical signals directly from hairy skin regardless of the amount or density of hair is fabricated using a polymer with an electrically conductive filler. The sensors have a stemmed conical microstructure array (CMSA) on the sensor surface that interfaces with and adheres to the skin between the hairs. The CMSA sensors are fabricated using a viscosity-controlled dip-pull process (VCDP), including dipping a mold into an electrically conductive polymer precursor having a selected viscosity that is optimized for formation of the conical microstructures upon a controlled pulling of the mold from the polymer precursor.
Apparatus and methods for detecting a brain disorder in a subject include a display device and an eye tracker operatively connected to a processor, wherein the display device displays visual scenes to the subject according to at least one viewing task. The eye tracker tracks at least one of the subject's eyes while the subject performs the viewing task, and outputs eye tracking data. The 5 processor extracts data for one or more selected feature, and analyzes the data for the one or more selected feature using a classifier to determine one or more condition, validates the determined condition through comparisons to meta-data and the true condition if available, and generates an output based on the determined condition for the selected feature: wherein the output indicates the likelihood of the subject having a brain disorder.
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
A61B 3/11 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring interpupillary distance or diameter of pupils
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Methods and apparatus for automatic material classification use proprioceptive sensing data acquired from equipment interacting with the material. Embodiments enable automatic material identification with low operational complexity and computational overhead. Automatic material classification may be used to improve autonomous operation of robotic excavators, as well as provide useful knowledge about excavation materials (e.g., rock size distribution) in fields such as civil and mining operations, military operations, aggregate material handling and processing, and space exploration and development to improve downstream processing and operations.
The Royal Institution for the Advancement of Learning/McGill University (Canada)
Inventor
Crudden, Cathleen M.
Barry, Seán
Goodwin, Eden Ramona
Ragogna, Paul
Lomax, Justin
Hedberg, Yolanda
Yang, Marshall Shuai
Senanayake, Waruni
Mauzeroll, Janine
Laundry-Mottiar, Lila
Suduwella, Thilini Malsha
Abstract
Stable, carbene-functionalized composite materials and methods and uses thereof are provided. The carbene-functionalized composite materials comprise a material having a metal surface and a carbene layer that is uniform, contaminant-free (metal oxide, etc), and more stable than thiol-functionalized monolayers. Studies are described that demonstrate carbene as a coating on steel, as well as other metals. Studies are described that demonstrate carbene as a primer for a topcoat on steel.
B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
Apparatus and method for measuring and monitoring intraocular pressure (IOP) of a subject includes a contact lens disposed on the subject's eye, the contact lens having a polymer matrix and a nanowire network embedded in the polymer matrix. An electrically conductive coil is disposed in close proximity to the contact lens such that it electromagnetically couples with the nanowire network of the contact lens. A resonant frequency of the electrically conductive coil is measured and correlated with the IOP of the subject. Changes in IOP result in deformation of the nanowire network of the contact lens and a resulting change in the resonant frequency, which is measured and correlated with the change in IOP. The electrically conductive coil is adapted to be worn by the subject and may be mounted on a pair of glasses.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
Five-level hybrid active clamped converters provide improved performance and switching device utilization over conventional five-level active neutral point clamped converters. Topologies include increased dc-link voltage relative to active neutral point clamped designs and enable capacitor voltage balancing, and are suitable for next generation high-power DC to AC converters, such as in photovoltaic applications, in both single phase and three phase configurations.
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
28.
Electrochemical Analysis of Water with Multiplex Electrodes
Methods and apparatus for analyzing water use a plurality of working electrodes and at least one counter electrode adapted to be in contact with the water, and a source of electrical potential difference that simultaneously applies to each of the plurality of working electrodes a different potential selected from at least one range of potentials. A multichannel device obtains chronoamperometry measurements from the plurality of working electrodes. The chronoamperometry measurements are used to generate a pattern of electrical charge on the plurality of electrodes, and the pattern of electrical charge is correlated with one or more known patterns to perform one or more of: identify one or more analytes in the water, perform speciation of analytes, and determine one or more concentration of the one or more analytes in the water.
Methods for recycling lithium and iron containing material, such as batteries, include selectively leaching lithium from the material by disposing the material in a powder form in a solution comprising formic acid and hydrogen peroxide, filtering the solution to obtain a first leach liquor comprising lithium and a residue comprising iron phosphate and carbon, subjecting the first leach liquor to a first precipitation to remove residual iron from the leach liquor and obtain a second leach liquor, and subjecting the second leach liquor to a second precipitation, wherein lithium is precipitated and a third leach liquor is obtained. The third leach liquor may be subjected to a third precipitation using trisodium phosphate or sodium carbonate. The material may be a battery cathode, such as a lithium iron phosphate battery cathode.
Compounds that are inhibitors of retinoic acid inducible P450 (CYP26) enzymes. The compounds have retinoid activity, are resistant to CYP26-mediated catabolism, act as inhibitors of CYP26B1, and are used for treating diseases that are responsive to retinoids.
C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
C07D 307/79 - Benzo [b] furansHydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
A controller for an open port interphase mass spectrometry (MS) probe automates analysis of samples, providing continuous, fast, and reproducible sampling. The sensed position of the probe above the sample surface is used by the controller in a feedback loop to set the probe at the proper position on the sample surface for sampling. One embodiment uses a conductance based sensor signal as input to the feedback loop to determine contact of the probe with the sample surface and to set the probe position according to a selected conductance value. The controller allows fast and automated sampling of uneven sample surfaces with minimal sample preparation while minimizing the risk of clogging the MS probe.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
32.
Sequential Mapping of Cardiac Arrhythmia without Fiducial Time Reference
A method for generating a propagation and velocity maps for cardiac wavefront propagation including cardiac arrhythmia, sinus rhythm, and paced rhythm. Activation time information is generated in the absence of any time alignment reference, wherein an estimated activation time is a weighted summation of potentially nonlinear and nonorthogonal candidate functions (CFs) selected from a bank of CFs. Time alignments between sequential recordings may be done by including binary level functions among selected CFs. Embodiments are applicable to single catheter mapping and sequential mapping, and are robust as confirmed by the ability to generate propagation maps and conduction velocity in the presence of multiple colliding wavefronts. The propagation and conduction velocity maps may be used for one or more of diagnosing cardiac arrhythmia, localizing cardiac arrhythmia, guiding catheter ablation therapy of cardiac arrhythmia, and guiding cardiac pacing therapy.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
Inventor
Mueller, Christopher R.
Abstract
Provided herein is a method for detecting a tumour that can be applied to cell-free samples, to cell-free detect circulating tumour DNA. The method utilizes detection of adjacent methylation signals within a single sequencing read as the basic positive tumour signal, thereby decreasing false positives. The method comprises extracting DNA from a cell-free sample obtained from a subject, bisulphite converting the DNA, amplifying regions methylated in cancer (CpG islands, CpG shores, and/or CpG shelves), generating sequencing reads, and detecting tumour signals. To increase sensitivity, biased primers designed based on bisulphite converted methylated sequences can be used. Target methylated regions can be selected from a pre-validated set according to the specific aim of the test. Absolute number, proportion, and/or distribution of tumour signals may be used for tumour detection or classification. The method is also useful in, predicting, prognosticating, and/or monitoring response to treatment, tumour load, relapse, cancer development, or risk.
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
G16B 35/00 - ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
G16B 99/00 - Subject matter not provided for in other groups of this subclass
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
Inventor
Mueller, Christopher R.
Abstract
Provided herein is a method for detecting a tumour that can be applied to cell-free samples, to cell-free detect circulating tumour DNA. The method utilizes detection of adjacent methylation signals within a single sequencing read as the basic positive tumour signal, thereby decreasing false positives. The method comprises extracting DNA from a cell-free sample obtained from a subject, bisulphite converting the DNA, amplifying regions methylated in cancer (CpG islands, CpG shores, and/or CpG shelves), generating sequencing reads, and detecting tumour signals. To increase sensitivity, biased primers designed based on bisulphite converted methylated sequences can be used. Target methylated regions can be selected from a pre-validated set according to the specific aim of the test. Absolute number, proportion, and/or distribution of tumour signals may be used for tumour detection or classification. The method is also useful in, predicting, prognosticating, and/or monitoring response to treatment, tumour load, relapse, cancer development, or risk.
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
G16B 35/00 - ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
G16B 99/00 - Subject matter not provided for in other groups of this subclass
A cancer vaccine includes at least one tumour associated antigen (TAA), at least one Toll-like receptor (TLR) agonist, at least one cytokine, and a pharmaceutically acceptable vehicle. The at least one TAA may be provided by dead tumour cells, such as γ-irradiated tumour cells or lysis and UV treated tumour cells, the at least one TLR agonist may comprise 5 CpG-1826 and the at least one cytokine may comprise IL-27. When administered to a mammalian subject the cancer vaccine prevents, inhibits, or slows tumour development in the subject, and the vaccine may provide a long-term T cell activation and memory against tumour development in the subject.
A method of beamforming by which a signal can be received into an array of channels, each of which is split into a real-part sub-channel and an imaginary part sub-channel. In each sub-channel, optical waves are used to carry the signal via waveguides. Each channel includes a real-part sub-channel where an optical wave is scaled by the real part of a complex number, and an imaginary part sub-channel, where a complementary optical wave is scaled by the complex part of the same complex number. When the complementary optical waves are received at the channel's output, they can be shifted by the phase of the complex number having defined their scaling. By processing a signal with a system operative to perform such method, the application of a different phase to each channel can result in a beamforming of the signal.
H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
A method and apparatus for tracking movement of an object in three-dimensional (3D) space uses a using a single sensor to capture images of the object moving through the 3D space. A change in change in position of the object in the 3D space is determined based on a change in size of the object in the images. The change in position is used to construct a trajectory of the object and the trajectory represents the movement of the object through the 3D space. Trajectories of a plurality of objects may be determined. The objects may be naturally occurring, or they may be manufactured and introduced into the 3D space. The determined trajectories may be used to characterize a flow field in the 3D space and produce an output comprising a 3D representation of the flow field.
A carbene coated metal surface is formed by applying a positive potential on a metal surface. applying a negative potential to a counter electrode and contacting them with a solution comprising free carbene, a salt of carbene, or a combination.
The present application provides stable, carbene-functionalized composite materials, and methods and uses thereof. These carbene-functionalized composite materials comprise a material having a metal surface, and a carbene monolayer that is uniform, contaminant-free (metal oxide, etc), and more stable than thiol-functionalized monolayers. Uses of such carbene-functionalized composite materials include semi-conducting materials, microelectronic devices, drug delivery or sensing applications.
B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
A61B 3/14 - Arrangements specially adapted for eye photography
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
41.
CONTROLLER FOR TWELVE-SWITCH ZERO INDUCTOR VOLTAGE CONVERTER
Controllers for a 12-switch zero inductor voltage stepdown converter implement at least one switching mode that decreases output voltages first and second phases of the converter to ½ the converter input voltage or less for corresponding first and second selected durations, wherein the output voltages of the first and second phases are phase shifted 180 degrees relative to each other. 5 In one mode the output voltages of the first and second phases are decreased to 0 V for the first and second durations. In another mode the output voltages of the first and second phases are decreased to ½ Vin for the first and second durations. An average output voltage of the converter is reduced in proportion to a time of the first and second selected durations, such that increased step-down ratios are achieved by the 12-switch ZIV converter.
H02M 1/084 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters using a control circuit common to several phases of a multi-phase system
H02M 1/088 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters for the simultaneous control of series or parallel connected semiconductor devices
H02M 3/157 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators with digital control
42.
METHODS, PROBE SETS, AND KITS FOR DETECTION OF DELETION OF TUMOR SUPPRESSOR GENES BY FLUORESCENCE IN SITU HYBRIDIZATION
Methods, probe sets, kits, and compositions for gene deletion assays are disclosed. In some embodiments, the methods relate to preparing probes for a deletion assay, performing a deletion assay, or optimizing a deletion assay. In some embodiments, the methods and probe sets can provide reduced artifactual deletion frequency, for example, when analyzing samples subject to truncation artifacts. In some embodiments, the methods and probe sets can distinguish between small and large deletions.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A control circuit for an isolated power converter includes a first sensing circuit that senses a secondary side output voltage and produces a pulse width modulation (PWM) signal having a duty cycle that is proportional to a value of the secondary side output voltage. The PWM is transferred a cross the converter isolation barrier to the primary side, and a primary side circuit receives the PWM signal and outputs a control signal. A controller determines the value of the secondary side output voltage from the control signal and uses the value to control primary side power switching devices of the isolated power converter to regulate the secondary side output voltage at a selected value.
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
A method for controlling a three phase neutral point clamped (NPC) converter independently controls switching devices of each phase to produce a reconstructed output voltage level of each phase based on a linear combination of three voltage levels of that phase. The method includes setting duty ratios of the switching devices of each phase to provide the reconstructed voltage level of each phase during a switching cycle, wherein the three voltage levels of each phase are 0,
A method for controlling a three phase neutral point clamped (NPC) converter independently controls switching devices of each phase to produce a reconstructed output voltage level of each phase based on a linear combination of three voltage levels of that phase. The method includes setting duty ratios of the switching devices of each phase to provide the reconstructed voltage level of each phase during a switching cycle, wherein the three voltage levels of each phase are 0,
Vdc
2
,
A method for controlling a three phase neutral point clamped (NPC) converter independently controls switching devices of each phase to produce a reconstructed output voltage level of each phase based on a linear combination of three voltage levels of that phase. The method includes setting duty ratios of the switching devices of each phase to provide the reconstructed voltage level of each phase during a switching cycle, wherein the three voltage levels of each phase are 0,
Vdc
2
,
and Vdc, where Vdc is the NPC converter input voltage. Controllers for three phase NPC converters produce drive signals for the switching devices according to the methods.
A photonic device configured to perform matrix vector multiplication operations at high frequencies is provided. The vector being multiplied by the matrix is defined by vector components at specific wavelengths. The device includes a first waveguide and a second waveguide. A series of tunable microring resonators (MRRs) are coupled to the first waveguide and to a respective series of passive delay rings (PDRs), which are coupled to the second waveguide. Each MRR/PDR pair defines a tunable matrix component (tunable weight) for a respective wavelength component of the vector. A series of controllable delay elements (CDEs) such as all-pass filters are coupled to the first waveguide, upstream from the tunable MRRs. Any tuning dependent group delay caused by the MRR/PDR pairs can be compensated by controlling the CDEs such that each wavelength components has substantially a same delay as the other wavelength components.
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
46.
METHODS AND CIRCUITS FOR TRANSFERRING A SIGNAL ACROSS AN ISOLATION BARRIER
Methods for transferring a signal across an isolation barrier include encoding the signal according to at least first and second parameters at a second side of the isolation barrier and using one or more isolating device to transfer the signal to a first side of the isolation barrier, where it is decoded to recover the at least first and second parameters. Encoding the signal may include encoding a first feature of the signal according to the first parameter and encoding a second feature of the signal according to the second parameter. Software products that implement the methods may be executed in processors on primary and secondary sides of an isolation barrier. An isolated power converter may include primary and secondary side controllers that execute the software products, wherein the parameters recovered on the primary side may be used to control the converter, such as for output voltage regulation.
H02M 3/00 - Conversion of DC power input into DC power output
H03M 7/00 - Conversion of a code where information is represented by a given sequence or number of digits to a code where the same information is represented by a different sequence or number of digits
H03M 13/09 - Error detection only, e.g. using cyclic redundancy check [CRC] codes or single parity bit
47.
Systems and methods to maintain phase relations of an optical signal in a photonic dot product engine
A photonic device configured to perform matrix vector multiplication operations at high frequencies is provided. The vector being multiplied by the matrix is defined by vector components at specific wavelengths. The device includes a first waveguide and a second waveguide. A series of tunable microring resonators (MRRs) are coupled to the first waveguide and to a respective series of passive delay rings (PDRs), which are coupled to the second waveguide. Each MRR/PDR pair defines a tunable matrix component (tunable weight) for a respective wavelength component of the vector. A series of controllable delay elements (CDEs) such as all-pass filters are coupled to the first waveguide, upstream from the tunable MRRs. Any tuning dependent group delay caused by the MRR/PDR pairs can be compensated by controlling the CDEs such that each wavelength components has substantially a same delay as the other wavelength components.
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
H04J 14/02 - Wavelength-division multiplex systems
G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data
48.
BATTERY CAPACITY CONTROLLER FOR MULTIPLE PORTABLE POWER STATIONS
Methods and controllers manage battery capacities of two or more portable power station (PPS) units connected together in a parallel arrangement to produce a total output current, wherein a first PPS unit operates as a voltage source and each of a second or more PPS unit operates as a current source. Each PPS unit communicates with a battery capacity controller (BCC) wherein each PPS transmits a battery capacity measure to the BCC at selected time intervals. The BCC uses the battery capacity measures to implement a battery capacity control strategy that determines the amount of output current each of the second or more PPS units contributes to the total output current at each time interval. The BCC transmits a control coefficient to each of the second or more PPS units corresponding to the determined amount of output current to be produced by each of the second or more PPS units.
th sub-combinations of DC outputs may be connected together in selected modes to produce a range of total output DC voltage, wherein the range of total output DC voltage is substantially free of double line frequency ripple and the converter modules are implemented without electrolytic output capacitors. The three phase rectifier is suitable for use in high power applications such as electric vehicle fast chargers.
H02M 3/00 - Conversion of DC power input into DC power output
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 7/04 - Conversion of AC power input into DC power output without possibility of reversal by static converters
H02M 7/17 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only arranged for operation in parallel
H02M 7/23 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only arranged for operation in parallel
A method for treatment of one or more toxin(s) in a subject, that includes administering to the subject a therapeutically effective amount of a serine protease that enzymatically cleaves certain toxins. Also, a method for preventing disease progression in a subject infected by Clostridioides difficile (CD), diarrhea, or infectious colitis, which includes administering to the subject a therapeutically effective amount of the protease. The protease retains its activity up to 65 °C. Treatment with the protease in mice infected with CD conferred a 10-fold survival benefit compared to mice infected with CD and untreated.
A portable power station (PPS) unit includes a controller that receives AC current information of AC input current at an AC input port and produces a control signal that is used to control the PPS unit to operate as a voltage source or a current source, and to control an AC output current at substantially the same magnitude, frequency, and phase as the AC input current. A PPS apparatus includes two or more PPS units connected together such that the AC output power of one PPS unit is connected to the AC input port of a next PPS unit; wherein a first PPS unit is a voltage source and each of the second or more PPS units is a current source, and a total AC output power of the PPS apparatus is substantially a sum of the AC output power produced by the two or more PPS units.
H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from AC mains by converters
H02J 7/34 - Parallel operation in networks using both storage and other DC sources, e.g. providing buffering
H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the networkCircuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
H02M 7/797 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
52.
POWER FACTOR CORRECTION WITH POWER BALANCING CONTROL FOR THREE-PHASE SINGLE-STAGE AC-DC CONVERTERS
Control strategies for phase-modular three-phase single-stage AC-DC converters with simultaneous power factor correction and power balancing features substantially cancel double line frequency ripple in the converter output voltage that is caused by an imbalance in the three-phase input voltages. The output capacitance of three-phase converters may be small even in the presence of unbalanced input voltages and power losses. A high-power factor (i.e., > 0.99) may be achieved in both balanced and unbalanced input phase voltage conditions with and without input voltage harmonics.
Transparent rollable omniphobic coatings are described that have exceptional hardness and wear resistance. The coatings have facile preparation. They are highly transparent and substrate can undergo inward bending on the inner side of a bend to radii < 1 mm without cracking. The polymer can be deposited in a single step to yield a coating that serves the dual function of an anti-smudge layer and a bendable protective layer with glass-like hardness and polymer-like flexibility.
A method of selective deposition that includes disposing in a deposition chamber a patterned substrate of side-by-side areas of metal and dielectric. The deposition chamber is connected to a bubbler that contains an N-heterocyclic carbenes (NHC) precursor. By heating the bubbler, gaseous free NHC is generated which is pulsed into the deposition chamber, where the NHC selectively chemisorbs onto the metal surface. Annealing after deposition of NHC improves surface patterning by removing stray metal from the dielectric section.
B05D 1/00 - Processes for applying liquids or other fluent materials
B05D 3/14 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
55.
Method and Apparatus for Generating an Electrocardiogram from a Photoplethysmogram
Electrocardiogram (ECG) is the electrical measurement of cardiac activity, whereas photoplethysmogram (PPG) is the optical measurement of volumetric changes in blood circulation. While both signals are used for heart rate monitoring, from a medical perspective, ECG is more useful as it carries additional cardiac information. For continuous cardiac monitoring, PPG sensors are practical. Methods for generating an ECG from a PPG signal may include subjecting the PPG signal to a deep learning network trained to generate a corresponding ECG. The deep learning network may include an adversarial model such as a generative adversarial network (GAN) that may use an attention-based generator to learn local salient features, and may also use dual discriminators to preserve the integrity of generated data in both time and frequency domains
Implantable compositions are based on polymers bearing pendant groups on the polymer backbone functionalized with short chain fatty acid groups, such as one or more of acetate, n-propionate, and n-butyrate by a degradable linkage. Upon a composition being implanted in a subject, such as a human, degradation of degradable linkage liberates the short chain fatty acid groups. The liberated short chain fatty acid groups may then participate in biochemical processes in the subject, which may produce a therapeutic benefit such as resolving inflammation, promoting tissue healing, and/or promoting tolerating self-antigens and neoantigens.
A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
A61K 9/00 - Medicinal preparations characterised by special physical form
Anionic switchable hydrophilicity solvents (ASHS) that can be reversibly converted between hydrophobic and hydrophilic forms are described. The ASHS comprise a carboxylic acid, a water-soluble base, water, and addition and removal of an acidic gas (CO2) effects the conversion between the hydrophobic and hydrophilic forms. A system and method for forming the ASHS are described, as well as applications utilizing the ASHS, including a method for separating a selected substance from a mixture, a method of removing gas from polymeric foam, and a method of extracting a hydrophobic material from a solid that is at least partially coated by the hydrophobic material.
A method of selective deposition that includes disposing in a deposition chamber a patterned substrate of side-by-side areas of metal and dielectric. The deposition chamber is connected to a bubbler that contains an N-heterocyclic carbenes (NHC) precursor. By heating the bubbler, gaseous free NHC is generated which is pulsed into the deposition chamber, where the NHC selectively chemisorbs onto the metal surface. Annealing after deposition of NHC improves surface patterning by removing stray metal from the dielectric section.
C23C 16/04 - Coating on selected surface areas, e.g. using masks
C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
H01L 21/32 - Treatment of semiconductor bodies using processes or apparatus not provided for in groups to form insulating layers thereon, e.g. for masking or by using photolithographic techniquesAfter-treatment of these layersSelection of materials for these layers using masks
Methods and apparatus for electrochemical analysis of water include acid cleaning a quartz crystal microbalance (QCM), stabilizing a QCM in analyte solution, and analyzing the solution by chronoamperometry and measuring a frequency shift of the QCM. The method may further include cleaning the QCM in an acid solution prior to stabilizing the QCM in analyte solution. The apparatus may provide at least semi-automated electrochemical analysis of water including determining a concentration of an analyte in a water sample, and communicating the concentration of the analyte over a network. The analyte may be manganese.
Methods for classifying neuroendocrine neoplasms (NENs) are based on comprehensive microRNA (miRNA) expression profiling and data mining of multiple pathological types. Reference miRNA expression profiles are generated for multiple NEN pathological types and site-matched non-NEN controls, and candidate category and type specific miRNAs are identified and used for 5 classification. A multilayer hierarchical classifier for discriminating NEN pathological types is based on the candidate category and type specific miRNAs. Methods and software products include products that enable construction of discriminator functions including hierarchical classifiers for discriminating among multiple conditions of interest in a dataset, the methods and software products being applicable to a wide range of data modalities, including, for example, omits data 0 such as miRNA expression data wherein multiple conditions of interest include different cancer pathologies.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
A green chemistry hydrometallurgical process for recovering one or more metals from a metal-containing material includes leaching the metal-containing material with formic acid, obtaining a leachate comprising the one or more metals as one or more metal formates, and precipitating at least one of the one or more metal formates. The metal-containing material may be a lithium-ion battery cathode material, resulting in Li formate remaining in solution and precipitation of salts including one or more of Ni, Co, and Mn formates. Steps may include filtration of the leachate, sulphurization of retained metal formate salts to produce metal sulphate salts, purification of filtered leachate by adding lithium carbonate and filtering, dewatering of the purified leachate, and thermal decomposition of resulting lithium salts to produce battery grade lithium carbonate. Carbon dioxide, water, and formic acid may be recovered and reused, without liquid or solid waste produced.
H01M 10/54 - Reclaiming serviceable parts of waste accumulators
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions
C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
C22B 3/22 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means
67.
Variable gain modulation methods and controllers for AC-DC converter with power factor correction
A controller for an AC-DC converter including a rectifier circuit that converts AC input voltage into DC output voltage uses control logic to control the rectifier circuit according to two or more operating modes. Each operating mode determines a gain of the rectifier circuit. The controller selects an operating mode from the two or more operating modes based on at least one of an AC input voltage value and a required DC output voltage value. The AC-DC converter provides a wide range of DC output voltage with power factor correction. The controller may be used with AC-DC converter topologies such as boost converter, isolated boost converter, PWM converter, LLC resonant converter, and LCC resonant converter.
H02M 1/15 - Arrangements for reducing ripples from DC input or output using active elements
H02M 1/10 - Arrangements incorporating converting means for enabling loads to be operated at will from different kinds of power supplies, e.g. from AC or DC
H02M 1/42 - Circuits or arrangements for compensating for or adjusting power factor in converters or inverters
H02M 3/00 - Conversion of DC power input into DC power output
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
68.
METHODS AND SYSTEMS TO PRODUCE FULLY-CONNECTED OPTICAL BEAMFORMING
A method of beamforming by which a signal can be received into an array of channels, each of which is split into a real-part sub-channel and an imaginary part sub-channel. In each sub-channel, optical waves are used to carry the signal via waveguides. Each channel includes a real-part sub-channel where an optical wave is scaled by the real part of a complex number, and an imaginary part sub-channel, where a complementary optical wave is scaled by the complex part of the same complex number. When the complementary optical waves are received at the channel's output, they can be shifted by the phase of the complex number having defined their scaling. By processing a signal with a system operative to perform such method, the application of a different phase to each channel can result in a beamforming of the signal.
Rapid calibration of a quantitative analysis instrument such as a mass spectrometer is performed using a calibration chip surface having different sized surface energy traps (SETs) and a transfer chip surface having same sized SETs, wherein the SETs of each chip surface are substantially aligned when they are disposed face to face. The calibration chip is exposed to an analyte solution 5 such that different sized droplets adhere to the different sized SETs, and the transfer chip is exposed to a standard solution such that same sized droplets adhere to the same sized SETs. The chips are aligned face to face in a spaced relationship such that at least a portion of each droplet of the standard solution is transferred to the SETs of the calibration chip. The chips are then separated and the calibration chip is used to calibrate the quantitative analysis instrument by sampling the SETs. 0
A coating that is able to shed accumulated material (such as ice) that includes a crosslinkable copolymer with hydrogen bonding moieties and liquid-like side chains, and an oil (or other non-aqueous liquid) that is compatible with the side-chains and that resides in the crosslinked coating and on the surface of the coating together with the side-chains that are on the external surface. Methods may use the coating for de-icing, shedding of marine organisms, and smudge-repellency.
A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. Analogs of Mycalolide B have been prepared and tested in breast and ovarian cancer cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells. The compounds have been shown to disrupt actin.
A61K 31/45 - Non-condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K 31/25 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/397 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
C07C 235/28 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
C07C 321/10 - Thiols having mercapto groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
C07D 205/08 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
C07D 207/27 - 2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
C07D 211/76 - Oxygen atoms attached in position 2 or 6
C07D 307/46 - Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
72.
AUTOMATED MASS SPECTROMETRY SAMPLING OF MATERIAL SURFACES
A controller for an open port interphase mass spectrometry (MS) probe automates analysis of samples, providing continuous, fast, and reproducible sampling. The sensed position of the probe above the sample surface is used by the controller in a feedback loop to set the probe at the proper position on the sample surface for sampling. One embodiment uses a conductance based sensor signal as input to the feedback loop to determine contact of the probe with the sample surface and to set the probe position according to a selected conductance value. The controller allows fast and automated sampling of uneven sample surfaces with minimal sample preparation while minimizing the risk of clogging the MS probe.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/26 - Mass spectrometers or separator tubes
A cancer vaccine includes at least one tumour associated antigen (TAA), at least one Toll-like receptor (TLR) agonist, at least one cytokine, and a pharmaceutically acceptable vehicle. The at least one TAA may be provided by dead tumour cells, such as γ-irradiated tumour cells or lysis and UV treated tumour cells, the at least one TLR agonist may comprise 5 CpG-1826 and the at least one cytokine may comprise IL-27. When administered to a mammalian subject the cancer vaccine prevents, inhibits, or slows tumour development in the subject, and the vaccine may provide a long-term T cell activation and memory against tumour development in the subject. 0
Apparatus and methods for detecting a brain disorder in a subject include a display device and an eye tracker operatively connected to a processor, wherein the display device displays visual scenes to the subject according to at least one viewing task. The eye tracker tracks at least one of the subject's eyes while the subject performs the viewing task, and outputs eye tracking data. The 5 processor extracts data for one or more selected feature, and analyzes the data for the one or more selected feature using a classifier to determine one or more condition, validates the determined condition through comparisons to meta‐data and the true condition if available, and generates an output based on the determined condition for the selected feature; wherein the output indicates the likelihood of the subject having a brain disorder.
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 3/113 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining or recording eye movement
76.
Methods and circuits for sensing isolated power converter output voltage across the isolation barrier
A control circuit for an isolated power converter includes a first sensing circuit that senses a secondary side output voltage and produces a pulse wave modulation (PWM) signal having a duty cycle that is proportional to a value of the secondary side output voltage. The PWM is transferred across the converter isolation barrier to the primary side, and a primary side circuit receives the PWM signal and outputs a control signal. A controller determines the value of the secondary side output voltage from the control signal and uses the value to control primary side power switching devices of the isolated power converter to regulate the secondary side output voltage at a selected value.
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 3/00 - Conversion of DC power input into DC power output
A series circuit includes a capacitor connected in series with output terminals of a power converter. The power converter provides an auxiliary voltage and a controller controls the auxiliary voltage according to a selected function, such that the series circuit behaves as a capacitor, an inductor, or an impedance, based on the selected function. The controller may sense a voltage across the capacitor and use the sensed voltage to control the auxiliary voltage according to the selected function. The series circuit may be connected in parallel with output terminals of an AC-DC converter, wherein the series circuit operates according to a selected mode to produce the auxiliary voltage, and the auxiliary voltage substantially cancels a low frequency AC voltage ripple across the capacitor, such that a substantially pure DC output voltage is delivered to the load.
H02M 1/42 - Circuits or arrangements for compensating for or adjusting power factor in converters or inverters
B60L 53/60 - Monitoring or controlling charging stations
H02J 3/18 - Arrangements for adjusting, eliminating or compensating reactive power in networks
H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from AC mains by converters
H02M 1/14 - Arrangements for reducing ripples from DC input or output
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
Methods and apparatus for automatic material classification use proprioceptive sensing data acquired from equipment interacting with the material. Embodiments enable automatic material identification with low operational complexity and computational overhead. Automatic material classification may be used to improve autonomous operation of robotic excavators, as well as provide useful knowledge about excavation materials (e.g., rock size distribution) in fields such as civil and mining operations, military operations, aggregate material handling and processing, and space exploration and development to improve downstream processing and operations.
A method and apparatus for tracking movement of an object in three‐dimensional (3D) space uses a using a single sensor to capture images of the object moving through the 3D space. A change in change in position of the object in the 3D space is determined based on a change in size of the object in the images. The change in position is used to construct a trajectory of the object and the trajectory represents the movement of the object through the 3D space. Trajectories of a plurality of objects may be determined. The objects may be naturally occurring, or they may be manufactured and introduced into the 3D space. The determined trajectories may be used to characterize a flow field in the 3D space and produce an output comprising a 3D representation of the flow field.
G01B 21/00 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
G01B 11/00 - Measuring arrangements characterised by the use of optical techniques
G01M 9/06 - Measuring arrangements specially adapted for aerodynamic testing
G01P 5/00 - Measuring speed of fluids, e.g. of air streamMeasuring speed of bodies relative to fluids, e.g. of ship, of aircraft
A hybrid energy storage device has at least two half cells, wherein each half cell includes an electrode comprising an electrically conductive high surface area material incorporating an electrolyte comprising a dissolved species that can exist in more than two redox states, and at least one separator that separates the at least two half cells and allows transfer of selected charge carriers between the half cells. After an initial charging, a redox pair of one half cell is different from the redox pair of the other half cell. The hybrid energy storage device operates as a battery for low power applications, and as a supercapacitor for high power applications. The hybrid energy storage device may be flexible.
The present application provides stable, carbene-functionalized composite materials, and methods and uses thereof. These carbene-functionalized composite materials comprise a material having a metal surface, and a carbene monolayer that is uniform, contaminant-free (metal oxide, etc), and more stable than thiol-functionalized monolayers. Uses of such carbene-functionalized composite materials include semi-conducting materials, microelectronic devices, drug delivery or sensing applications.
B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
B32B 15/04 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance
Pharmaceutical compositions that include inhibitors of mitochondrial fission are described for the treatment and/or mitigation of cancer, pulmonary arterial hypertension, cardioprotection, stroke, coronary heart disease, neurological disorder, a neurodegenerative disease, Parksinonism, Huntington's Chorea, Alzheimer's disease, diabetic cardiomyopathy, fatty liver diseases, non-alcoholic fatty liver diseases, or alcohol-related liver disease.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A hydrogel battery includes a first compartment comprising a first electrode metal and a first hydrogel and a second compartment comprising a second electrode metal and a second hydrogel, and a background electrolyte (BGE) metal ion species. At least one of the first and second hydrogels selectively coordinates ions of the respective first and second electrode metals. The first hydrogel and the second hydrogel allow the BGE metal ion species to travel between the first and second compartments. A hydrogel battery may be implemented without a separator disposed between the first and second compartments, and may be rechargeable and/or flexible.
A sensor element comprises a metallic nanostructure formed at edges of at least two microelectrodes on a non-electrically conductive substrate. The nanostructure is formed by depositing a solution comprising at least one metal salt and a stabilizing agent on the substrate at a detection site between the microelectrodes, and applying an AC electric field to the electrodes. The sensor elements may be used in sensing platforms such as surface-enhanced Raman scattering (SERS), surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR), and in electrical-based sensing such as electrochemical sensing.
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means
B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.
A61B 3/16 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for measuring intraocular pressure, e.g. tonometers
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
86.
RECOVERY OF METALS FROM MATERIALS CONTAINING LITHIUM AND IRON
Methods for recycling lithium and iron containing material, such as batteries, include selectively leaching lithium from the material by disposing the material in a powder form in a solution comprising formic acid and hydrogen peroxide, filtering the solution to obtain a first leach liquor comprising lithium and a residue comprising iron phosphate and carbon, subjecting the first leach liquor to a first precipitation to remove residual iron from the leach liquor and obtain a second leach liquor, and subjecting the second leach liquor to a second precipitation, wherein lithium is precipitated and a third leach liquor is obtained. The third leach liquor may be subjected to a third precipitation using trisodium phosphate or sodium carbonate. The material may be a battery cathode, such as a lithium iron phosphate battery cathode.
Her Majesty the Queen in Right of Canada, Minister of the Department of National Defence (DND) (Canada)
Inventor
Weber, Kela P.
Turner, Lauren
Battye, Nick
Kueper, Bernard
Hendry, Andrew Jason
Abstract
A method for remediating PFAS-contaminated soil comprises measuring the initial moisture content of the PFAS-contaminated soil, optionally drying the PFAS-contaminated soil, and ball milling the PFAS-contaminated soil with or without the use of milling additives.
A composition and method for promoting wound healing that includes hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been substituted.
Electrocardiogram (ECG) is the electrical measurement of cardiac activity, whereas photoplethysmogram (PPG) is the optical measurement of volumetric changes in blood circulation. While both signals are used for heart rate monitoring, from a medical perspective, ECG is more useful as it carries additional cardiac information. For continuous cardiac monitoring, PPG sensors are practical. Methods for generating an ECG from a PPG signal may include subjecting the PPG signal to a deep learning network trained to generate a corresponding ECG. The deep learning network may include an adversarial model such as a generative adversarial network (GAN) that may use an attention‐based generator to learn local salient features, and may also use dual discriminators to preserve the integrity of generated data in both time and frequency domains.
A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
A61B 5/318 - Heart-related electrical modalities, e.g. electrocardiography [ECG]
A61B 5/327 - Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads
Disclosed are novel gene therapy constructs containing both HEXA and HEXB genes to treat GM2 gangliosidoses, including Sandhoff disease and Tay-Sach's disease. Also described are co-treatments using chaperone and anti-inflammatory agents to enhance the effects of gene therapy.
Controllers and methods for controlling a resonant power converter output voltage include operating the power converter according to a control period comprising an on cycle operation mode for a duration T_on that produces a first voltage Vo1 and an off cycle operation mode for a duration T_off that produces a second voltage Vo2. Vo1 is produced using a first switching frequency for a first selected number of switching cycles corresponding to the on time T_on. The converter output voltage or the converter input and output voltages may be sensed and used to determine the switching frequency during the on cycle operation mode and the duration of the off cycle operation mode. The final output voltage of the power converter is regulated to a selected value based on a ration of (T_on):(T_on+T_off). The controllers and methods may be used with power converters in power delivery devices to accept wide input voltage ranges compatible with devices such as cell phones, tablet computers, and notebook computers.
H02M 1/10 - Arrangements incorporating converting means for enabling loads to be operated at will from different kinds of power supplies, e.g. from AC or DC
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
Methods for classifying neuroendocrine neoplasms (NENs) are based on comprehensive microRNA (miRNA) expression profiling and data mining of multiple pathological types. Reference miRNA expression profiles are generated for multiple NEN pathological types and site‐matched non‐NEN controls, and candidate category and type specific miRNAs are identified and used for 5 classification. A multilayer hierarchical classifier for discriminating NEN pathological types is based on the candidate category and type specific miRNAs. Methods and software products include products that enable construction of discriminator functions including hierarchical classifiers for discriminating among multiple conditions of interest in a dataset, the methods and software products being applicable to a wide range of data modalities, including, for example, omics data 0 such as miRNA expression data wherein multiple conditions of interest include different cancer pathologies.
C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
A multi-gene model is employed in methods for accurately classifying benign and malignant prostate cancer and reliably identifying prostate cancer in samples, with false positive and negative rates below 7%. A single gene model is employed in methods for detecting aggressive prostate cancer, prostate cancer patients at risk of developing biochemical recurrence, and prostate cancer patients suitable for treatment with an additional and/or alternative therapy. The methods may be implemented with next generation sequencing (NGS) or methylation-specific PCR (MSP). The MSP may use a mastermix specifically designed for use with bisulfite converted DNA in singleplex and multiplex assays.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
