A biological fluid analyser is provided, the biological fluid analyser comprising an imaging system comprising a light source assembly configured to emit light; a first lens assembly configured to direct the light from the light source assembly to directly or indirectly define a probing light; the imaging system defining a probing volume configured to receive probing light and configured to receive a container comprising a prepared biological fluid sample; the biological fluid analyser comprising a controller configured to control the light source assembly according to a light configuration, wherein the light source assembly, in response to a first light control signal, is configured to emit light according to a first light configuration, and wherein the light source assembly, in response to a second light control signal, is configured to emit light according to a second light configuration.
A biological fluid analyser is disclosed. The biological fluid analyser is configured to obtain image data of one or more image planes of an image stack in a prepared biological fluid sample. The image data comprises first image data associated with a first image plane. To obtain the first image data comprises to obtain first primary image data of the first image plane. The first primary image data is associated with a first incident light setting. The first incident light setting has a first angular light distribution. To obtain the first image data comprises to obtain first secondary image data of the first image plane. The first secondary image data is associated with a second incident light setting. The second incident light setting has a second angular light distribution. The biological fluid analyser is configured to classify, based on the first primary image data and the first secondary image data, a cell in the prepared biological fluid sample for provision of a cell parameter associated with the cell.
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G01N 15/1433 - Signal processing using image recognition
G06V 10/14 - Optical characteristics of the device performing the acquisition or on the illumination arrangements
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
A computer-implemented method for installing software on an analyzer apparatus configured to operate in a first or second mode, wherein the first mode is associated with a cold start-up of the analyzer apparatus and the second mode is associated with a warm start-up of the analyzer apparatus, and wherein the analyzer apparatus accommodates one or more sensor device and consumables. The method comprises the steps of obtaining a software installer image comprising a set of software components to be installed on the analyzer apparatus, determining whether the analyzer apparatus is to start-up in the first or second mode, and when the analyzer apparatus is to start-up in the first mode: installing the obtained software installer image comprising the set of software components on the analyzer apparatus, starting-up the analyzer apparatus in the first mode, and when the analyzer apparatus is to start-up in the second mode: obtaining data related to a state of the analyzer apparatus, storing the obtained data in a storage device, installing the obtained software installer image comprising the set of software components on the analyzer apparatus, re-applying the state of the analyzer apparatus based on the obtained data stored in the storage device, and starting-up the analyzer apparatus in the second mode.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
4.
BIOLOGICAL FLUID ANALYSER WITH ADAPTIVE APERTURE DEVICE
A biological fluid analyser is provided, the biological fluid analyser comprising an imaging system comprising a light source assembly configured to emit light; a first lens assembly configured to direct the light from the light source assembly; an aperture device configured to apply an aperture to allow light from the first lens assembly to pass through the aperture in order to indirectly define a probing light; the imaging system defining a probing volume configured to receive the probing light and configured to receive a container comprising a prepared biological fluid sample; the biological fluid analyser comprising a controller configured to control the aperture device according to an aperture configuration, wherein the aperture device, in response to a first aperture control signal, is configured to apply an aperture with a first aperture configuration, and wherein the aperture device, in response to a second aperture control signal, is configured to apply an aperture with a second aperture configuration.
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
There is presented an apparatus for analyzing one or more fluids and comprising an analysis unit for analyzing one or more fluids, such as human blood, a liquid inlet port, and a liquid outlet port, a cartridge comprising a pouch comprising a liquid, such as an aqueous liquid, an absorbing element, wherein the absorbing element is capable of absorbing water, and wherein the absorbing element is arranged exterior to the pouch and fluidically connected to an exterior surface of the pouch, a liquid outlet port being fluidically connected to the pouch, and a liquid inlet port being fluidically connected to the element, wherein the liquid inlet port of the analysis unit is fluidically connected with the liquid outlet port of the cartridge, and the liquid outlet port of the analysis unit is fluidically connected with the liquid inlet port of the cartridge.
The present disclosure relates to a method for operating a sensor device for an analyser apparatus configured to analyse parameters of blood samples. The method comprising the steps of: providing the sensor device, the sensor device comprising: a measurement chamber defining an interior volume for receiving a fluid to be analysed, a chamber inlet and a chamber outlet, a reference electrode in fluid communication with the interior volume, and one or more ion-selective analyte sensors; measuring an electric potential of a blood sample in the interior volume using the reference electrode and at least one of the analyte sensors; and filling the interior volume with an idling liquid, the idling liquid comprising an anti-microbial agent, the anti-microbial agent comprising a sulfur-containing compound. The method further comprises a step of providing a sulfur-reactive agent in the interior volume to at least partially bind the sulfur-containing compound of the anti-microbial agent.
The present disclosure relates to a sensor device for an analyser apparatus configured to analyse parameters of medical fluid samples. The sensor device comprises: a measurement chamber defining an interior volume for receiving a fluid to be analysed; a chamber inlet and a chamber outlet, each respectively providing a respective fluid passage to the interior volume; a reference electrode arranged in fluid communication with the interior volume; and one or more ion-selective analyte sensors, wherein each of the analyte sensors comprises a sensor electrode and an ion-selective sensor membrane arranged between the interior volume and the sensor electrode. The sensor device further comprises a sulfur-reactive element arranged in fluid communication with the interior volume to thereby fluidly contact the fluid to be analysed when the interior volume receives the fluid to be analysed. The disclosure further relates to an analyser apparatus and use of a sulfur-reactive element.
Disclosed herein are embodiments of an apparatus for measuring an amount of analyte in a biological sample, the biological sample being present inside an upwardly open sample cup, the sample cup including one or more binding partners of the analyte so that the analyte present in the biological sample is allowed to bind to the one or more binding partners. The apparatus comprises a wash unit for washing the sample cup, in particular to remove elements of no interest for the ongoing analysis from the sample cup.
A computer-implemented method performed by a central system for establishing control ranges for a plurality of remote medical analyzer devices is disclosed. The method comprises obtaining a plurality of measurement results associated with a plurality of quality control (QC) measurements performed by a plurality of medical analyzer devices on a set of predefined QC samples. Each QC sample is associated with a predefined target range and wherein each medical analyzer device is associated with a peer group of medical analyzer devices. The method further comprises determining, for each peer group out of a plurality of peer groups, a peer control range for each predefined QC sample by processing the plurality of measurement results of the peer group in view of the associated target range. Furthermore, the method comprises determining, for each medical analyzer device, a control range for each predefined QC sample based on the determined peer control range of the associated peer group. The method further comprises transmitting, to a device for managing at least one medical analyzer device, data indicative of the determined control ranges for the set of predefined QC samples for the at least one medical analyzer device.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A computer-implemented method for supporting maintenance of an apparatus for analyzing biological samples, the apparatus including at least one hardware component subject to maintenance, the method comprising: receiving a plurality of measurement results, each measurement result being derived from a measurement performed by the apparatus for analyzing biological samples on a biological sample or on a quality control sample, the plurality of measurement results including measurement results obtained at different times; computing a time series of a performance parameter from the plurality of measurement results, the performance parameter being indicative of an operational state of said at least one hardware component, the time series representing a period of time having a start time and an end time, the end time being no later than a current time; extrapolating, using a predetermined extrapolation model, the computed time series to obtain an extrapolated time series of the performance parameter, the extrapolated time series including one or more estimated values of the performance parameter at one or more future times; comparing the one or more estimated values of the performance parameter with a predetermined condition indicative of a risk of component failure of said component to determine an estimated future time at which said predetermined condition is fulfilled; determining an estimated failure time from the estimated future time
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
11.
METHODS AND APPARATUSES FOR FACILITATING MAINTENANCE OF A MEDICAL ANALYZER DEVICE
A computer-implemented method for facilitating maintenance of a medical analyzer device is disclosed. The method comprises obtaining a plurality of measurement results associated with a plurality of quality control (QC) measurements performed by a plurality of medical analyzer devices on a plurality of predefined QC samples. Each QC sample is associated with a predefined target range and each medical analyzer device is associated with a peer group of medical analyzer devices. The method further comprises, for each medical analyzer device, evaluating the obtained measurement results against measurement results of the associated peer group in order to identify a deviation of at least one QC measurement parameter. Then, if a deviation above a predefined threshold is identified, the method further comprises obtaining an action log of the medical analyzer device. The action log comprises data indicative of any previously transmitted maintenance actions associated with the medical analyzer device. Moreover, the method comprises obtaining at least one suggested maintenance action for the medical analyzer device associated with the identified deviation based on a type of QC measurement parameter that is associated with the identified deviation. The method further comprises, selecting a maintenance action for the medical analyzer device associated with the identified deviation from the at least one suggested maintenance action based on the obtained action log. Furthermore, the method comprises transmitting, to a device for managing the medical analyzer device associated with the identified deviation, data indicative of an instruction to execute the selected maintenance action for the medical analyzer device.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
A blood analyzer for analyzing multiple blood parameters is disclosed. The blood analyzer comprises an inlet module configured to receive an initial blood sample, a blood gas sensor device in fluid communication with the inlet module, the blood gas sensor device configured to receive a first blood sample of the initial blood sample and conduct a blood gas analysis on the first blood sample to determine a blood gas analysis parameter, a blood count sensor device in fluid communication with the inlet module, the blood count sensor device configured to receive a second blood sample of the initial blood sample and determine a blood count parameter, and an output configured to provide the blood gas analysis parameter and the blood count parameter.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
G01N 15/06 - Investigating concentration of particle suspensions
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 15/1433 - Signal processing using image recognition
A helical mixer for a blood analyzer is disclosed. The blood analyzer comprises an inlet configured to receive a blood sample and a reagent. The blood analyzer comprises an outlet configured to output a mixture of the blood sample and the reagent. The blood analyzer comprises a helical flow path extending between the inlet and the outlet. The helical mixer is configured to mix the blood sample with the reagent.
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
B01F 25/51 - Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle in which the mixture is circulated through a set of tubes, e.g. with gradual introduction of a component into the circulating flow
B01F 35/221 - Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
C08L 27/12 - Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogenCompositions of derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
G01N 1/38 - Diluting, dispersing or mixing samples
The invention relates to a sealed bag containing a reference fluid for the calibration or quality control of a sensor element for measuring body fluid parameters, the bag comprising peripheral walls of a first layered material. The bag further comprises an access port formed by an opening in the first layered material, wherein the opening is sealed by a cover of a second layered material, wherein the second layered material is more resistant to oxidation by the reference fluid than the first layered material.
A blood gas analyzer (1) for performing a measurement on analyte parameters in a blood sample, such as a whole blood sample, aspirated into the blood gas analyzer (1) from a handheld blood sample container (100) comprises a controller (8), and a sensor system (5) for detecting a presence, a position and/or an orientation of the handheld blood sample container (100) relative to an inlet structure (12a/b). An aspiration system is provided for aspirating the blood sample from the handheld blood sample container (100), the aspiration system connectable to the handheld blood sample container (100). A user interface system is provided for outputting instructions to a user (102) of the blood gas analyzer (1), the instructions being selected among pre-stored sets of instructions. The controller (8) selects one of the at least two sets of pre-stored sets of instructions based on an assessment of a signal retrieved from the sensor system.
A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
17.
COMPUTER-IMPLEMENTED METHOD OF MONITORING A TRANSCUTANEOUS SENSOR FOR MEASURING PARTIAL PRESSURE OF ONE OR MORE BLOOD GASES OF A PATIENT
According to a first aspect of the present invention, a computer-implemented method of monitoring a transcutaneous sensor configured for measuring partial pressure of one or more blood gases of a patient is presented. The method comprises the steps of determining a response time parameter of the transcutaneous sensor (step S1). The method further comprises the step of determining, based on the determined response time parameter, whether a partial pressure measuring capability of the sensor is sufficient (step S2). This method may not only detect an increase of the response time of the sensor due to a dry membrane, which may occur after several days of using a membrane with the sensor. The method may also detect deterioration of the sensor, which may occur only after several years of using the sensor.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/1495 - Calibrating or testing in vivo probes
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
18.
MANAGEMENT OF QUALITY CONTROL OF ANALYZING DEVICES CONFIGURED TO PERFORM ANALYSIS OF BIOLOGICAL SAMPLES
A computer-implemented method is disclosed for managing quality control of analyzing devices configured to perform analysis of biological samples. Each of the analyzing devices is configured to perform measurements on biological samples and provide parameter values based on the measurements. Quality control of an analyzing device comprises provision of quality control parameter values by performing measurements on samples of a quality control set, and comparison of the quality control parameter values to acceptance ranges associated with the quality control set. The method comprises receiving (from one of the analyzing devices) quality control data comprising quality control results associated with a quality control set identifier, and evaluating the received quality control results in relation to requirements for quality control set validation responsive to an initial reception of quality control data for the quality control set identifier. Responsive to the received quality control results passing the evaluation, the method comprises storing acceptance ranges for the quality control set in association with the quality control set identifier, for further quality controls with the quality control set identifier. Corresponding computer program product, computer-based data processing system, server node, arrangement, and use are also disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
19.
IMAGE PROCESSING DURING BIOLOGICAL SAMPLE ANALYSIS
There is provided an image processing system. The system is configured to: receive at least one captured image depicting a) at least a portion of a collected biological sample, b) at least a portion of a container containing the biological sample, or both a) and b); process the received image to identify one or more characteristics of i) the biological sample, ii) the container, or both i) and ii); and output signals based on the identified one or more characteristics for result handling. The one or more characteristics comprise a pre-analytic sample condition of the biological sample.
A waste pouch for biological waste from a blood analyser device is provided, as well as a cassette comprising said waste pouch, and a blood analyser device comprising said pouch or said cassette. The pouch comprises an envelope, a vent in the upper surface of the envelope for outlet of gas, and an opening for receiving liquid and gaseous waste. The pouch comprises a superabsorbent polymer contained in the envelope, said superabsorbent polymer being in the form of beads.
There is presented a method of measuring one or more potential differences being indicative of one or more concentrations of one or more analyte ions in a sample, such as being a liquid whole blood sample, said method comprising, measuring with a reference ion measurement setup a parameter indicative of a concentration of a reference ion in the sample wherein the reference ion measurement setup is different from an electroanalytical measurement setup, measuring with an analyte ion measurement setup one or more potential differences directly or indirectly between each of one or more, optionally solid-state, working electrodes with each of said, optionally solid-state, working electrodes comprising an ion-selective electrode which is selective for an analyte ion, and an, optionally solid state, reference electrode which is selective for the reference ion wherein the analyte ion measurement setup is an electroanalytical setup. There is additionally presented an apparatus and use of said apparatus.
G01N 27/27 - Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
G01N 27/333 - Ion-selective electrodes or membranes
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
22.
AN APPARATUS FOR DETERMINING INFORMATION RELATING TO ELEMENTS OF A BODY FLUID AND A METHOD OF DETERMINING THAT INFORMATION
An apparatus and a method of determining information relating to particles, such as cells, in a liquid where images are generated with different focus lengths/depths and at different points in time. From the images, the particle movement over time is determined for a plurality of individual cells, bacteria, platelets or the like and therefrom their densities and/or types.
G01N 15/05 - Investigating sedimentation of particle suspensions in blood
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G03H 1/00 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto
There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (11) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.
A system (10) for determining a refractive index of a sample fluid or a concentration of a component in the sample fluid comprises a transparent sensing element (12) with a plurality of pores (122) for receiving a fluid. The pores reflect or scatter radiation emitted by a radiation emitter (14) of the system differently depending on the refractive index of the fluid. The system comprises one or more detectors (16) for detecting the reflected and/or scattered radiation. The refractive index of the sample fluid is determined based on the detected scattered and/or reflected radiation when the sample fluid is fed into the pores, the corresponding detected scattered and/or reflected radiation when first and second calibration fluids having predetermined refractive indices and predetermined absorptions at at least two wavelengths are fed into the pores, said predetermined refractive indices and said predetermined absorptions. Alternatively, a concentration of a component in the sample fluid absorbing at a given wavelength may be determined based on the detected scattered and/or reflected radiation, a predetermined refractive index of the sample fluid, a predetermined refractive index and a predetermined absorption at said wavelength of a calibration fluid, and the detected scattered and/or reflected radiation when the calibration fluid is fed into the pores.
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
A computer-implemented method of controlling operator interaction with one or more operator devices is disclosed. The one or more operator devices comprise one or more analyzing devices configured to analyze biological samples. The method comprises, responsive to any of the one or more analyzing devices being triggered by the operator to perform an analysis of a sample, acquiring—in association with an identifier of the operator—information regarding any sample associated handling error detected by the triggered analyzing device. The method also comprises dynamically updating handling error data associated with the identifier of the operator based on the information regarding detected handling errors, and controlling—for the identifier of the operator—interaction with at least one of the one or more operator devices based on the handling error data associated with the identifier of the operator. A computer-implemented method of an analyzing device is also disclosed. The method comprises, responsive to the analyzing device being triggered by the operator to perform an analysis of a sample, detecting any sample associated handling error. The method also comprises, in response to detection of a handling error, providing—in association with an identifier of the operator—information regarding the detected handling error for dynamic updating of handling error data associated with the identifier of the operator. Corresponding apparatus, server, storage device, analyzing device, operator device, system, and computer program product are also disclosed.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
26.
DETERMINING TIME RESPONSE VALUE OF AN ANALYTE IN A LIQUID
There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (I I) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.
There is presented an apparatus (100) for automatically measuring an analyte concentration in a liquid sample (102) comprising the analyte and cell-free hemoglobin and for automatically determining a cell-free hemoglobin interference criticality, said apparatus comprising one or more sensors (104) for measuring the analyte concentration in the liquid sample, and a cell-free hemoglobin concentration in the liquid sample, and further comprising a data processing device (106) comprising a processor configured to determine the cell-free hemoglobin interference criticality based on the cell-free hemoglobin concentration, and the analyte concentration, and output a signal (108) indicative of the cell-free hemoglobin interference criticality at least in case the cell-free hemoglobin interference criticality is within a predetermined range.
A blood sampler is disclosed. The blood sampler contains a solid mixture comprising a compound selected from iloprost, beraprost, treprostinil, cicaprost, carbacyclin, EP 157 ((Z)-7-[(1R,2R,3R,4S)-3-[(Z)-benzhydryloxyiminomethyl]-2-bicyclo[2.2.2]oct-5-enyl]hept-5-enoic acid), FK-788 (2-[[(6R)-6-(diphenylcarbamoyloxymethyl)-6-hydroxy-7,8-dihydro-5H-naphthalen-1-yl]oxy]acetic acid), and taprostene, as well as any stereoisomers and salts thereof, wherein said compound is dispersed in a matrix of a water-soluble polymer material and/or a sugar.
A blood analyser and related methods, in particular a method of analysing a blood sample is disclosed. The blood analyser comprises a memory, an interface, and one or more processors. The blood analyser is configured to obtain image data of a prepared blood sample; select a first image associated with a first image plane of the prepared blood sample from the image data; characterize the first image, wherein the characterization of the first image comprises to determine a first set of cell regions belonging to the first image plane; and determine a first blood parameter based on the first set of cell regions.
A method of preparation of a blood sample with a reagent for hematology is disclosed. The method comprises combining a blood sample with an initial volume of a first reagent for provision of an initial mixture, monitoring the initial mixture, wherein monitoring the initial mixture comprises obtaining a first blood parameter of a first blood component of the initial mixture, determining a first combination scheme based on the first blood parameter, and adding a first volume of the first reagent and/or a first volume of a second reagent to the initial mixture according to the first combination scheme for provision of a first mixture
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A blood analyser and related methods, in particular a method of analysing a blood sample is disclosed. The blood analyser comprises a memory, an interface, and one or more processors. The blood analyser is configured to obtain image data of a prepared blood sample; select a first image associated with a first image plane of the prepared blood sample from the image data; characterize the first image, wherein the characterization of the first image comprises to determine a first set of cell regions belonging to the first image plane; select a first distal image associated with a first distal image plane on a distal side of the first image plane, and determine a first distal set of distal cell regions associated with the first set of cell regions; and determine a first cell parameter for each cell region of the first set of cell regions based on the first distal set of distal cell regions.
The present invention relates a porous membrane sensor element for the detection of an analyte in a complex fluid sample. The porous membrane sensor element comprises: a porous membrane sensor housing penetrated by a flow channel defining an axial direction, the flow channel comprising a sample space; a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane, wherein the pores are configured with regard to the analyte for diffusive fluid communication with the sample space; and an optical subassembly comprising a light guide core, the light guide core comprising an input branch, an output branch, and a coupling interface arranged to contact a backside of the porous membrane opposite to the front side and facing away from the sample space; wherein the input and output branches are directed towards the coupling interface. The input branch and the output branch are arranged in a common light guide plane arranged perpendicular to the sensor surface. According to a further aspect, a sensor assembly comprises a porous membrane sensor element integrated within a sample chamber thereof.
There is presented a porous unit (1) for detection of an analyte (96) in a liquid (99) by optical probing, comprising a translucent element (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted directly with the liquid (99), or separated from the liquid (99), such as exclusively separated from the liquid (99), by one or more layers at the front side (3) of the translucent element (2), the one or more layers (5) being adapted to be non-reflective to light reaching the one or more layers at least at one angle of incidence, such as at least at normal incidence, from the translucent element (2), and/or allow internal reflection, such as total internal reflection, at an interface, such as an external interface, of light reaching the interface from the translucent element (2), wherein the translucent element (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) fluidically connecting them with the liquid (99) at the front side (3) into the translucent element (2), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte in the liquid (99) to enter the pores (6) via diffusion.
A method for determining defocus in image data related to a prepared blood sample, by means of a blood analyser, is disclosed. Image data related to a prepared blood sample arranged in a probing volume is obtained by means of an imaging system, the image data comprising data related to at least one imaging plane corresponding to a depth of the prepared blood sample. The image data is analysed by identifying an object region in the obtained image data, the object region comprising a group of pixels in the image data which corresponds to an object being physically present in the prepared blood sample, and identifying an optical feature of the identified object region, the optical feature originating from a difference in refractive index between the object and a medium of the prepared blood sample, and the optical feature acting as an additional artefact in the image data that does not represent an object being physically present in the prepared blood sample. At least a direction of defocus in the image data is determined, based on an appearance of the identified optical feature.
Disclosed is a method for transmitting data from an analyser system (1) comprising one or more analyser devices (5) to a remote server (3), wherein the one or more analyser devices (5) are configured to obtain data from samples and/or measurements taken of a patient. The method comprises determining data to be transmitted based on one or more rules associated with a geographical and/or an organizational location of the analyser system (1), and transmitting the determined data to the remote server (3). Corresponding computer program product, analyser system, remote server, and health care system are also disclosed.
Disclosed herein are embodiments of a method for calibrating a group of analyzer units, each analyzer unit of the group of analyzer units configured for determining an amount of an analyte in plasma of a whole-blood sample. The method comprises: providing a plurality of calibration whole-blood samples, the plurality of calibration whole-blood samples including calibration whole-blood samples having respective hematocrit levels, for each calibration whole-blood sample of the plurality of calibration whole-blood samples: measuring a hematocrit measurement value indicative of the hematocrit level of said calibration whole-blood sample, measuring a wholeblood measurement value indicative of an amount of the analyte in the calibration whole-blood sample using at least one calibration analyzer unit of said group of analyzer units, measuring a plasma measurement value indicative of an amount of the analyte in plasma of said calibration whole-blood sample, and computing a ratio between the whole-blood measurement value and the plasma measurement value; generating a nonlinear functional relationship between the computed ratios and the corresponding hematocrit measurement values by curve fitting of a nonlinear function parametrized by one or more calibration parameters, the curve fitting resulting in respective parameter values of the one or more calibration parameters; storing a representation of the fitted nonlinear function in each analyzer unit of the group of analyzer units to allow each analyzer unit of the group of analyzer units to compute a hematocrit correction factor.
A blood gas analyzer (1) for performing a measurement on analyte parameters in a blood sample, such as a whole blood sample, aspirated into the blood gas analyzer from a blood sample container comprises an output device, such as a monitor (30), for outputting instructions to a user of the blood gas analyzer for the user's handling of the one or more of the user-accessible parts of the blood gas analyzer, such as for maintenance purposes, and/or for replacement of sensor cassettes, gaskets, probes, solution packs, etc. A controller (8) is provided for receiving a signal, on the basis of which it is determined if an instruction, such as an animated video instruction, is to be presented to the user. In the affirmative, the controller selects one of a plurality of pre-stored sets of instructions for outputting at the output device.
A biological fluid analyser is provided, the biological fluid analyser comprising an imaging system comprising a light source assembly configured to emit light; a first lens assembly configured to direct the light from the light source assembly to directly or indirectly define a probing light; the imaging system defining a probing volume configured to receive probing light and configured to receive a container comprising a prepared biological fluid sample; the biological fluid analyser comprising a controller configured to control the light source assembly according to a light configuration, wherein the light source assembly, in response to a first light control signal, is configured to emit light according to a first light configuration, and wherein the light source assembly, in response to a second light control signal, is configured to emit light according to a second light configuration.
A biological fluid analyser is disclosed. The biological fluid analyser is configured to obtain image data of one or more image planes of an image stack in a prepared biological fluid sample. The image data comprises first image data associated with a first image plane. To obtain the first image data comprises to obtain first primary image data of the first image plane. The first primary image data is associated with a first incident light setting. The first incident light setting has a first angular light distribution. To obtain the first image data comprises to obtain first secondary image data of the first image plane. The first secondary image data is associated with a second incident light setting. The second incident light setting has a second angular light distribution. The biological fluid analyser is configured to classify, based on the first primary image data and the first secondary image data, a cell in the prepared biological fluid sample for provision of a cell parameter associated with the cell.
A biological fluid analyser is provided, the biological fluid analyser comprising an imaging system comprising a light source assembly configured to emit light; a first lens assembly configured to direct the light from the light source assembly; an aperture device configured to apply an aperture to allow light from the first lens assembly to pass through the aperture in order to indirectly define a probing light; the imaging system defining a probing volume configured to receive the probing light and configured to receive a container comprising a prepared biological fluid sample; the biological fluid analyser comprising a controller configured to control the aperture device according to an aperture configuration, wherein the aperture device, in response to a first aperture control signal, is configured to apply an aperture with a first aperture configuration, and wherein the aperture device, in response to a second aperture control signal, is configured to apply an aperture with a second aperture configuration.
Disclosed is a method and device/apparatus for determination of the contribution from lysed cells to measurement values of an analyte present in the extracellular compartment. The method employs multiple tandem measurements of analyte and an intracellular marker from samples where different numbers of cells are lysed so as to establish the relationship between the measured value of the intracellular marker and the analyte.
G01N 33/84 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving inorganic compounds or pH
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
42.
APPARATUS COMPRISING CARTRIDGE WITH ABSORBING ELEMENT
There is presented an apparatus for analyzing one or more fluids and comprising an analysis unit for analyzing one or more fluids, such as human blood, a liquid inlet port, and a liquid outlet port, a cartridge comprising a pouch comprising a liquid, such as an aqueous liquid, an absorbing element, wherein the absorbing element is capable of absorbing water, and wherein the absorbing element is arranged exterior to the pouch and fluidically connected to an exterior surface of the pouch, a liquid outlet port being fluidically connected to the pouch, and a liquid inlet port being fluidically connected to the element, wherein the liquid inlet port of the analysis unit is fluidically connected with the liquid outlet port of the cartridge, and the liquid outlet port of the analysis unit is fluidically connected with the liquid inlet port of the cartridge.
The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space. The sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
A syringe for obtaining a target volume of blood is presented. The syringe (1) comprises a barrel (2), wherein a plunger (4) is arranged within the barrel (2) to be displaceable along a displacement direction (X). Furthermore the barrel (2) and the plunger (4) together provide for a first stop (20) and second stop (22), wherein the first stop (20) is configured for positioning a filter (100) at a predetermined location along the displacement direction (X) thereby defining a target volume of blood and a buffer volume. Moreover, the second stop (22) is configured to stop the plunger (4) from expelling more than the buffer volume from the syringe (1) for obtaining the target volume of blood when the plunger (4) is pushed towards the distal end (30) of the syringe (1) along the displacement direction (X). In addition, the syringe (1) facilitates that the syringe (1) fills itself with the target volume of blood by a self-filling procedure using blood that is under pressure, like arterial blood, and using the filter (100) located in the plunger (4).
A computer-implemented method for supporting maintenance of an apparatus for analyzing biological samples, the apparatus including at least one hardware component subject to maintenance, the method comprising: receiving a plurality of measurement results, each measurement result being derived from a measurement performed by the apparatus for analyzing biological samples on a biological sample or on a quality control sample, the plurality of measurement results including measurement results obtained at different times; computing a time series of a performance parameter from the plurality of measurement results, the performance parameter being indicative of an operational state of said at least one hardware component, the time series representing a period of time having a start time and an end time, the end time being no later than a current time; extrapolating, using a predetermined extrapolation model, the computed time series to obtain an extrapolated time series of the performance parameter, the extrapolated time series including one or more estimated values of the performance parameter at one or more future times; comparing the one or more estimated values of the performance parameter with a predetermined condition indicative of a risk of component failure of said component to determine an estimated future time at which said predetermined condition is fulfilled; determining an estimated failure time from the estimated future time.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
46.
CONTROL RANGES FOR DEVICES FOR BIOLOGICAL SAMPLE ANALYSIS
A computer-implemented method performed by a central system for establishing control ranges for a plurality of remote medical analyzer devices is disclosed. The method comprises obtaining a plurality of measurement results associated with a plurality of quality control (QC) measurements performed by a plurality of medical analyzer devices on a set of predefined QC samples. Each QC sample is associated with a predefined target range and wherein each medical analyzer device is associated with a peer group of medical analyzer devices. The method further comprises determining, for each peer group out of a plurality of peer groups, a peer control range for each predefined QC sample by processing the plurality of measurement results of the peer group in view of the associated target range. Furthermore, the method comprises determining, for each medical analyzer device, a control range for each predefined QC sample based on the determined peer control range of the associated peer group. The method further comprises transmitting, to a device for managing at least one medical analyzer device, data indicative of the determined control ranges for the set of predefined QC samples for the at least one medical analyzer device.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
47.
METHODS AND APPARATUSES FOR FACILITATING MAINTENANCE OF A MEDICAL ANALYZER DEVICE
A computer-implemented method for facilitating maintenance of a medical analyzer device is disclosed. The method comprises obtaining a plurality of measurement results associated with a plurality of quality control (QC) measurements performed by a plurality of medical analyzer devices on a plurality of predefined QC samples. Each QC sample is associated with a predefined target range and each medical analyzer device is associated with a peer group of medical analyzer devices. The method further comprises, for each medical analyzer device, evaluating the obtained measurement results against measurement results of the associated peer group in order to identify a deviation of at least one QC measurement parameter. Then, if a deviation above a predefined threshold is identified, the method further comprises obtaining an action log of the medical analyzer device. The action log comprises data indicative of any previously transmitted maintenance actions associated with the medical analyzer device. Moreover, the method comprises obtaining at least one suggested maintenance action for the medical analyzer device associated with the identified deviation based on a type of QC measurement parameter that is associated with the identified deviation. The method further comprises, selecting a maintenance action for the medical analyzer device associated with the identified deviation from the at least one suggested maintenance action based on the obtained action log. Furthermore, the method comprises transmitting, to a device for managing the medical analyzer device associated with the identified deviation, data indicative of an instruction to execute the selected maintenance action for the medical analyzer device.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
48.
METHOD FOR CALIBRATING AN IMMUNOASSAY DEVICE TO DETERMINE THE CONCENTRATION OF AN ANALYTE
The present invention relates to a method of calibrating an immunoassay device for determining the concentration of an analyte in a sample. The device can be calibrated without using a calibration standard having a known concentration of the analyte or without using a calibration measuring cell.
System (10) for controlling a timing of consecutive biological samples (s0, s1) from a patient for a medical test (T), comprising:
a registration device (30), configured for determining a patient id (PID) indicating an identity of the patient, and a first sample time point (t0) indicating a time of obtaining a first biological sample (s0) from the patient at a first time point (t0);
a processing system (20), communicatively connected to the registration device (30), configured for
receiving the patient id (PID) and the first sample time point (t0) from the registration device (30);
determining a protocol rule (R) for the medical test (T) relating to timing requirements of obtaining biological samples (s0, s1) from the patient depending on the medical test (T); and
determining a sample timing dependent on the protocol rule (R) and the first sample time point (t0), indicating when to obtain a second biological sample (s1) from the patient in compliance with the protocol rule (R).
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/65 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The present disclosure relates to a sensor device, comprising: a measurement chamber having at least a first wall, the measurement chamber including a plurality of analyte sensors; wherein the measurement chamber allows a fluid to be analyzed to interact with each of the plurality of analyte sensors when the fluid is accommodated within the measurement chamber; the measurement chamber having an inlet configured to receive the fluid to be analyzed and an outlet configured to allow the fluid to exit the measurement chamber after having interacted with the plurality of analyte sensors; the measurement chamber defining a sample volume for accommodating the fluid to be analyzed, the sample volume extending at least between the inlet and the outlet; a heating element configured to heat the fluid accommodated within the measurement chamber.
There is provided an image processing system. The system is configured to: receive at least one captured image depicting a) at least a portion of a collected biological sample, b) at least a portion of a container containing the biological sample, or both a) and b); process the received image to identify one or more characteristics of i) the biological sample, ii) the container, or both i) and ii); and output signals based on the identified one or more characteristics for result handling. The one or more characteristics comprise a pre-analytic sample condition of the biological sample.
There is presented a method for of measuring one or more potential differences being indicative of one or more concentrations of one or more analyte ions in a sample (102), such as being a liquid whole blood sample, said method comprising, measuring with a reference ion measurement setup (104) a parameter indicative of a concentration of a reference ion in the sample wherein the reference ion measurement setup (104) is different from an electroanalytical measurement setup, measuring with an analyte ion measurement setup (105) one or more potential differences directly or indirectly between each of one or more, optionally solid-state, working electrodes with each of said, optionally solid-state, working electrodes comprising an ion-selective electrode which is selective for an analyte ion, and an, optionally solid state, reference electrode which is selective for the reference ion wherein the analyte ion measurement setup is an electroanalytical setup. There is additionally presented an apparatus (100) and use of said apparatus.
A system (10) for determining a refractive index of a sample fluid or a concentration of a component in the sample fluid comprises a transparent sensing element (12) with a plurality of pores (122) for receiving a fluid. The pores reflect or scatter radiation emitted by a radiation emitter (14) of the system differently depending on the refractive index of the fluid. The system comprises one or more detectors (16) for detecting the reflected and/or scattered radiation. The refractive index of the sample fluid is determined based on the detected scattered and/or reflected radiation when the sample fluid is fed into the pores, the corresponding detected scattered and/or reflected radiation when first and second calibration fluids having predetermined refractive indices and predetermined absorptions at at least two wavelengths are fed into the pores, said predetermined refractive indices and said predetermined absorptions. Alternatively, a concentration of a component in the sample fluid absorbing at a given wavelength may be determined based on the detected scattered and/or reflected radiation, a predetermined refractive index of the sample fluid, a predetermined refractive index and a predetermined absorption at said wavelength of a calibration fluid, and the detected scattered and/or reflected radiation when the calibration fluid is fed into the pores.
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
A computer-implemented method of controlling operator interaction with one or more operator devices is disclosed. The one or more operator devices comprise one or more analyzing devices configured to analyze biological samples. The method comprises, responsive to any of the one or more analyzing devices being triggered by the operator to perform an analysis of a sample, acquiring - in association with an identifier of the operator - information regarding any sample associated handling error detected by the triggered analyzing device. The method also comprises dynamically updating handling error data associated with the identifier of the operator based on the information regarding detected handling errors, and controlling - for the identifier of the operator - interaction with at least one of the one or more operator devices based on the handling error data associated with the identifier of the operator. A computer-implemented method of an analyzing device is also disclosed. The method comprises, responsive to the analyzing device being triggered by the operator to perform an analysis of a sample, detecting any sample associated handling error. The method also comprises, in response to detection of a handling error, providing - in association with an identifier of the operator - information regarding the detected handling error for dynamic updating of handling error data associated with the identifier of the operator. Corresponding apparatus, server, storage device, analyzing device, operator device, system, and computer program product are also disclosed.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
56.
DETERMINING TIME RESPONSE VALUE OF AN ANALYTE IN A LIQUID
There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (11) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.
There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (11) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
A blood sampler is disclosed. The blood sampler contains a solid mixture comprising a compound selected from iloprost, beraprost, treprostinil, cicaprost, carbacyclin, EP 157 ((Z)-7-[(1R,2R,3R,4S)-3-[(Z)-benzhydryloxyiminomethyl]-2-bicyclo[2.2.2]oct-5-enyl]hept-5-enoic acid), FK-788 (2-[[(6R)-6-(diphenylcarbamoyloxymethyl)-6-hydroxy-7,8-dihydro-5H-naphthalen-1-yl]oxy]acetic acid), and taprostene, as well as any stereoisomers and salts thereof, wherein said compound is dispersed in a matrix of a water-soluble polymer material and/or a sugar.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
59.
BLOOD ANALYSER WITH OUT-OF-FOCUS IMAGE PLANE ANALYSIS AND RELATED METHODS
A blood analyser and related methods, in particular a method of analysing a blood sample is disclosed. The blood analyser comprises a memory, an interface, and one or more processors. The blood analyser is configured to obtain image data of a prepared blood sample; select a first image associated with a first image plane of the prepared blood sample from the image data; characterize the first image, wherein the characterization of the first image comprises to determine a first set of cell regions belonging to the first image plane; select a first distal image associated with a first distal image plane on a distal side of the first image plane, and determine a first distal set of distal cell regions associated with the first set of cell regions; and determine a first cell parameter for each cell region of the first set of cell regions based on the first distal set of distal cell regions.
A method of preparation of a blood sample with a reagent for hematology, the method comprising obtaining a first blood parameter of a first blood component of the blood sample, determining a preparation scheme based on the first blood parameter, and preparing the blood sample with a reagent according to the preparation scheme.
G01N 1/38 - Diluting, dispersing or mixing samples
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
G01N 33/487 - Physical analysis of biological material of liquid biological material
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types
G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A blood analyzer for analyzing multiple blood parameters is disclosed. The blood analyzer comprises an inlet module configured to receive an initial blood sample, a blood gas sensor device in fluid communication with the inlet module, the blood gas sensor device configured to receive a first blood sample of the initial blood sample and conduct a blood gas analysis on the first blood sample to determine a blood gas analysis parameter, a blood count sensor device in fluid communication with the inlet module, the blood count sensor device configured to receive a second blood sample of the initial blood sample and determine a blood count parameter, and an output configured to provide the blood gas analysis parameter and the blood count parameter.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 15/06 - Investigating concentration of particle suspensions
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
A helical mixer for a blood analyzer is disclosed. The blood analyzer comprises an inlet configured to receive a blood sample and a reagent. The blood analyzer comprises an outlet configured to output a mixture of the blood sample and the reagent. The blood analyzer comprises a helical flow path extending between the inlet and the outlet. The helical mixer is configured to mix the blood sample with the reagent.
B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
B01F 25/51 - Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle in which the mixture is circulated through a set of tubes, e.g. with gradual introduction of a component into the circulating flow
B01F 35/221 - Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
B01F 35/92 - Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 15/06 - Investigating concentration of particle suspensions
The present invention relates to methods for determining a blood gas parameter and/or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and/or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.
There is presented a porous unit (1) for detection of an analyte (96) in a liquid (99) by optical probing, comprising a translucent element (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted directly with the liquid (99), or separated from the liquid (99), such as exclusively separated from the liquid (99), by one or more layers at the front side (3) of the translucent element (2), the one or more layers (5) being adapted to be non-reflective to light reaching the one or more layers at least at one angle of incidence, such as at least at normal incidence, from the translucent element (2), and/or allow internal reflection, such as total internal reflection, at an interface, such as an external interface, of light reaching the interface from the translucent element (2), wherein the translucent element (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) fluidically connecting them with the liquid (99) at the front side (3) into the translucent element (2), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte in the liquid (99) to enter the pores (6) via diffusion.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
There is presented an apparatus (100) for automatically measuring an analyte concentration in a liquid sample (102) comprising the analyte and cell-free hemoglobin and for automatically determining a cell-free hemoglobin interference criticality, said apparatus comprising one or more sensors (104) for measuring the analyte concentration in the liquid sample, and a cell-free hemoglobin concentration in the liquid sample, and further comprising a data processing device (106) comprising a processor configured to determine the cell-free hemoglobin interference criticality based on the cell-free hemoglobin concentration, and the analyte concentration, and output a signal (108) indicative of the cell-free hemoglobin interference criticality at least in case the cell-free hemoglobin interference criticality is within a predetermined range.
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
66.
BLOOD ANALYSER WITH IMAGE PLANE ANALYSIS AND RELATED METHODS
A blood analyser and related methods, in particular a method of analysing a blood sample is disclosed. The blood analyser comprises a memory, an interface, and one or more processors. The blood analyser is configured to obtain image data of a prepared blood sample; select a first image associated with a first image plane of the prepared blood sample from the image data; characterize the first image, wherein the characterization of the first image comprises to determine a first set of cell regions belonging to the first image plane; and determine a first blood parameter based on the first set of cell regions.
A method of preparation of a blood sample with a reagent for hematology is disclosed. The method comprises combining a blood sample with an initial volume of a first reagent for provision of an initial mixture, monitoring the initial mixture, wherein monitoring the initial mixture comprises obtaining a first blood parameter of a first blood component of the initial mixture, determining a first combination scheme based on the first blood parameter, and adding a first volume of the first reagent and/or a first volume of a second reagent to the initial mixture according to the first combination scheme for provision of a first mixture.
G01N 1/38 - Diluting, dispersing or mixing samples
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
68.
Method and sensor for detecting presence or absence of a contaminant
The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201). The method comprises steps of: filling the measurement chamber with a fluid sample; applying a stimulus to the luminophor in the sensor layer; detecting luminescence emitted from the luminophor in the sensor layer in response to the stimulus as a function of time; obtaining a time sequence of measurement values for the detected luminescence; based on the time sequence, determining an actual value of a first parameter and an actual value of a second parameter, wherein one of the first and second parameters is sensitive to a change in refractive index across the interface between the sensor layer and the measurement chamber, and wherein the other one of the first and second parameters is not sensitive to said change in refractive index across the interface between the sensor layer and the measurement chamber; developing an expected value for the second parameter based on the actual value of the first parameter; comparing the expected value for the second parameter to the actual value of the second parameter; and determining the presence (or absence) of a contaminant based on the comparison. In a further aspect, a sample analyzer configured for detecting contaminants in the measurement chamber using embodiments of the above method is provided.
The present invention relates to a method of operating an apparatus for analyzing biological samples, the apparatus comprising: a receptacle for receiving a replaceable sensor module, the sensor module comprising one or more sensors and a writable memory; a measurement unit configured to bring a biological sample into operational interaction with at least a first sensor of the one or more sensors of a sensor module received by said receptacle, to obtain a measurement result responsive to the interaction between at least the first sensor and the biological sample and to output the obtained measurement result; a control unit configured to control operation of the measurement unit; an data exchange interface configured to receive data from the writable memory and to forward data to the sensor module for storage in the writable memory; and a communications interface for communicating with a remote host system; wherein the method comprises performing the following steps by the control unit: receiving, from the remote host system via said communications interface, one or more operational parameters associated with the sensor module; causing writing, via said data exchange interface, the received one or more operational parameters to the writable memory; and controlling operation of the measurement unit in accordance with the received one or more operational parameters.
G01N 33/487 - Physical analysis of biological material of liquid biological material
H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
Disclosed is a method for transmitting data from an analyser system (1) comprising one or more analyser devices (5) to a remote server (3), wherein the one or more analyser devices (5) are configured to obtain data from samples and/or measurements taken of a patient. The method comprises determining data to be transmitted based on one or more rules associated with a geographical and/or an organizational location of the analyser system (1), and transmitting the determined data to the remote server (3). Corresponding computer program product, analyser system, remote server, and health care system are also disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
71.
Method for calibrating a device for measuring the concentration of creatinine
A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
72.
METHOD OF DETECTING THE PRESENCE OR ABSENCE OF A CLOT IN A LIQUID SAMPLE ANALYZER
A method of detecting a clot in a measurement chamber (2) of a liquid sample analyzer (1), the liquid sample analyzer (1) comprising one or more analyte sensors (3, 4), each one of the one or more analyte sensors (3, 4) being arranged for measuring a physical parameter for a respective analyte in a liquid sample in the measurement chamber (2), wherein detection is performed after conclusion of a rinsing procedure with a primary solution (Call) having a pre-determined primary composition with a primary level of the analyte, the method comprising the steps of (a) at least partly filling the measurement chamber (2) with a secondary solution (Rinse/Call) having a pre-determined secondary composition with a respective secondary level for each of the analytes, wherein the respective secondary level is different from the respective primary level; (b) immediately after filling the measurement chamber (2) with the secondary solution (Rinse/Call), obtaining an initial measurement result by each of the one or more analyte sensors (3, 4); (c) flushing the measurement chamber (2) with the secondary solution (Rinse/Call); (d) after a time delay with respect to the initial measurement result, obtaining a subsequent measurement result by each of the one or more analyte sensors (3, 4); (e) comparing the respective initial and subsequent measurement results; and (f) determining presence or absence of a clot in the measurement chamber based on the comparison.
The disclosure relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second or more sequence of measurement results, and (e) comparing the change of the first sequence of measurement results with the second sequence of measurement results.
A blood gas analyzer (1) for performing a measurement on analyte parameters in a blood sample, such as a whole blood sample, aspirated into the blood gas analyzer from a blood sample container comprises an output device, such as a monitor (30), for outputting instructions to a user of the blood gas analyzer for the user's handling of the one or more of the user-accessible parts of the blood gas analyzer, such as for maintenance purposes, and/or for replacement of sensor cassettes, gaskets, probes, solution packs, etc. A controller (8) is provided for receiving a signal, on the basis of which it is determined if an instruction, such as an animated video instruction, is to be presented to the user. In the affirmative, the controller selects one of a plurality of pre-stored sets of instructions for outputting at the output device.
A blood gas analyzer (1) for performing a measurement on analyte parameters in a blood sample, such as a whole blood sample, aspirated into the blood gas analyzer (1) from a handheld blood sample container (100) comprises a controller (8), and a sensor system (5) for detecting a presence, a position and/or an orientation of the handheld blood sample container (100) relative to an inlet structure (12a/b). An aspiration system is provided for aspirating the blood sample from the handheld blood sample container (100), the aspiration system connectable to the handheld blood sample container (100). A user interface system is provided for outputting instructions to a user (102) of the blood gas analyzer (1), the instructions being selected among pre-stored sets of instructions. The controller (8) selects one of the at least two sets of pre-stored sets of instructions based on an assessment of a signal retrieved from the sensor system.
The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g. selected from a calcium-selective ionophore, a potassium-selective ionophore, and a sodium-selective ionophore), and wherein the first ionophore is not present in any ion-selective electrode in the sensor array other than in the first ion-selective electrode.
G01N 27/333 - Ion-selective electrodes or membranes
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
h) having a first wettability for aqueous solutions; and a second sensor (20) adapted to measure a second parameter of body fluids, the second sensor (20) having a second sensor surface (21) exposed to the inside of the measurement chamber (2) at a second axial position upstream or downstream from the first axial position, the second sensor surface (21) having a second wettability for aqueous solutions higher than the first wettability. At the second axial position, the chamber width exceeds the width of the second sensor surface (21), and the measurement chamber has a widening (22) in a horizontal direction as compared to the first axial position.
Processes for preparing ion selective membranes are presented which have selectivity for a primary analyte (in particular magnesium) as well as another ion (in particular calcium), wherein said process comprises addition of a) an ionophore (in particular 1,10-phenanthroline), b) a lipophilic salt containing said primary analyte (in particular hemi-magnesium bis[4-octylphenyl]phosphate) and c) a lipophilic salt containing said other ion (in particular hemi-calcium bis[4-octylphenyl]phosphate). Also, ion selective membranes are presented which are prepared using said processes, in particular to membranes selective for magnesium ions. In further aspects, electrodes and potentiometric sensors are presented comprising such membranes and the use thereof for determining ion concentrations in samples.
Ion selective membranes and the preparation thereof, such as magnesium ion selective membranes and the preparation thereof. In particular, the invention describes improved PVC polymer blends for use in ion selective membranes. The invention furthermore relates to electrodes and potentiometric sensors comprising such membranes and the use thereof for determining ion concentrations in samples.
Disclosed herein are apparatus for generating predicted consumable state data of a point-of-care medical analyzer comprising an input unit and a processing unit. Also disclosed are methods for generating predicted consumable state data of a point-of-care medical analyzer comprising receiving initial consumable state data of a point-of-care medical analyzer defining an initial amount of a point-of-care medical analyzer consumable present in the point-of-care medical analyzer, and an analyzer identifier at a first time index, receiving a second time index, and generating predicted consumable state data defining an amount of the point-of-care medical analyzer consumable predicted to be present in the point-of-care medical analyzer at the second time index using a predicted consumable depletion model selected using at least the analyzer identifier and the initial consumable state data. Additionally disclosed are systems comprising at least one point-of-care medical analyzer, an apparatus as disclosed herein, and a data communications network.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
Magnesium ion selective electrode membranes and the preparation thereof. The membranes are rendered highly selective for magnesium ions by the addition of acidic groups to the preferably PVC membrane, either by introducing a lipophilic compound comprising an acidic group covalently linked to a C4-C18 alkyl-substituted phenyl group (e.g. bis-4-octylphenyl phosphoric acid) into the membrane comprising the magnesium selective ionophore (e.g. a neutral ionophore 1,10-phenanthroline derivative) or by covalently linking an acidic (e.g. a carboxylic) group to the ionophore (e.g. a 1,10-phenanthroline derivative).
wherein the filter openings (FOP) are arranged as line openings having their longitudinal direction in parallel with the direction of propagation (DOP) of light guided by the waveguide layer (WGL).
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G02B 6/42 - Coupling light guides with opto-electronic elements
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
A system of medical devices, the system comprising: a medical device data management system; a plurality of medical devices communicatively connected to the medical device data management system; each medical device being operable to analyze one or more samples of biological material; and to communicate information about an operational state of the medical device to the medical device data management system; a plurality of portable electronic devices, each operable to be carried by an operator, each portable electronic device communicatively connectable to the medical device data management system and configured to receive, from the medical device data management system, information indicative of an operational state of respective medical devices and to display the received information in respect of one or more selected ones of the medical devices.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
84.
SENSOR ASSEMBLY AND POROUS MEMBRANE SENSOR ELEMENT
The present invention relates a porous membrane sensor element for the detection of an analyte in a complex fluid sample. The porous membrane sensor element comprises: a porous membrane sensor housing penetrated by a flow channel defining an axial direction, the flow channel comprising a sample space; a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane, wherein the pores are configured with regard to the analyte for diffusive fluid communication with the sample space; and an optical subassembly comprising a light guide core, the light guide core comprising an input branch, an output branch, and a coupling interface arranged to contact a backside of the porous membrane opposite to the front side and facing away from the sample space; wherein the input and output branches are directed towards the coupling interface. The input branch and the output branch are arranged in a common light guide plane arranged perpendicular to the sensor surface. According to a further aspect, a sensor assembly comprises a porous membrane sensor element integrated within a sample chamber thereof.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
A syringe for obtaining a target volume of blood is presented. The syringe (1) comprises a barrel (2), wherein a plunger (4) is arranged within the barrel (2) to be displaceable along a displacement direction (X). Furthermore the barrel (2) and the plunger (4) together provide for a first stop (20) and second stop (22), wherein the first stop (20) is configured for positioning a filter (100) at a predetermined location along the displacement direction (X) thereby defining a target volume of blood and a buffer volume. Moreover, the second stop (22) is configured to stop the plunger (4) from expelling more than the buffer volume from the syringe (1) for obtaining the target volume of blood when the plunger (4) is pushed towards the distal end (30) of the syringe (1) along the displacement direction (X). In addition, the syringe (1) facilitates that the syringe (1) fills itself with the target volume of blood by a self-filling procedure using blood that is under pressure, like arterial blood, and using the filter (100) located in the plunger (4).
The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space. The sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
The invention relates to a multiple-use device (1), wherein a fluid sample, in particular a blood sample, may enter a measuring chamber (3) of the device (1) via an inlet (16), flow through the measuring chamber (3) and leave the measuring chamber (3) via an outlet (17). The device (1) comprises an inner wall surface (9) defining an outer limit of the measuring chamber (3) The inner wall surface (9) comprises a surface structure (13) which is adapted to control a propagation of a flow front (6) of the fluid sample (4) in a direction (x) while the fluid sample (4) enters into the measuring chamber (3) via the inlet (16), while the fluid sample (4) flows through the measuring chamber (3), and while the fluid sample (4) leaves the measuring chamber (3) via the outlet (17). The shape of the surface structure (13) may be selected depending on a flow speed of the flow front (6) of the fluid sample (4), wherein the flow speed may be applied by a difference in pressure between the inlet (16) and the outlet (17) of the measuring chamber (3).
System (10) for controlling a timing of consecutive biological samples (s0, s1) from a patient for a medical test (T), comprising: a registration device (30), configured for determining a patient id (PID) indicating an identity of the patient, and a first sample time point (t0) indicating a time of obtaining a first biological sample (s0) from the patient at a first time point (t0); a processing system (20), communicatively connected to the registration device (30), configured for - receiving the patient id (PID) and the first sample time point (t0) from the registration device (30); - determining a protocol rule (R) for the medical test (T) relating to timing requirements of obtaining biological samples (s0, s1) from the patient depending on the medical test (T); and - determining a sample timing dependent on the protocol rule (R) and the first sample time point (t0), indicating when to obtain a second biological sample (s1) from the patient in compliance with the protocol rule (R).
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
89.
Porous optical fiber for the detection of an analyte in a fluid
The invention relates to a porous optical fiber for the detection of an analyte in a fluid by optical probing. The optical fiber has a first end and a second end opposite to the first end, as seen in a longitudinal direction, and a circumferential surface delimiting the optical fiber in radial directions perpendicular to the longitudinal direction. The optical fiber comprises a core adapted for supporting at least one optical mode propagating in the longitudinal direction, the core having a circumferential interface delimiting the core in the radial directions. The optical fiber further comprises pores penetrating from an opening at the circumferential surface through the circumferential interface into the core of the optical fiber, wherein a cross-sectional dimension of the openings is dimensioned so as to prevent a particulate fraction of the fluid from entering the pores, while allowing the analyte to enter the pores.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
90.
IN-VITRO HEMOLYSIS DETECTION AND CORRECTION OF AT LEAST ONE BLOOD PARAMETER IN A WHOLE BLOOD SAMPLE
The present invention relates to methods for analyzing at least one blood parameter in a whole blood sample of a patient, wherein the in vitro hemolysis of a whole blood sample is determined. The present invention also relates to a corresponding analysis apparatus, a system for analysing a whole blood sample and a computer program element for controlling the analysis apparatus as well as a computer readable medium storing the computer program element. A method is provided for differentiating the contributions from in-vivo hemolysis and in-vitro hemolysis of an overall hemolysis level determined for the whole blood sample. Blood parameters like potassium or lactate dehydrogenase can then be corrected for hemolytic interference factors.
The invention relates to a patient sample analysis system. The system comprises: at least one medical analysis device adapted to receive a sample, perform a measurement on the sample, and produce a measurement result based on the measurement, wherein the measurement result has a unique identifier; and a medical device management apparatus comprising an input interface adapted to collect the measurement result from the at least one medical analysis device, an output interface adapted to output sample analysis data based on the measurement result towards a point of delivery, and at least one processing module arranged in a data path extending from an upstream end at the input interface to a downstream end at the output interface. The patient sample analysis system further comprises: one or more check points arranged in the data path, wherein each check point is configured to identify the result by the unique identifier and to add a corresponding result status entry in relation to the unique identifier to a check point record, when the result is passed through said check point; and an error handler operable to inspect the check point record, detect the occurrence of an error based on that inspection, determine an error location of the error on the data path, and develop an error correction based on the error location. In a further aspect, a corresponding method for handling medical sample analysis is disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A sensor element (101) for detecting an analyte in a fluid sample by optical probing comprises a translucent membrane (110) with a front side (111) defining a sensor surface for contacting a fluid sample, and a back side (112) facing away from the front side (111). The sensor element (101) has a reflective layer (114) at the front side (111) of the translucent membrane (110). An optical input port (120) is connected to the back side (112) of the translucent membrane (110) for feeding probing light to the translucent membrane (110) through the back side (112). An optical output port (130) is connected to the back side (112) of the translucent membrane (110) for collecting an optical response from the translucent membrane (110) through the backside (112). The sensor element further comprises an optical constriction element (140) with a screen element (141) arranged between the input port (120) and the output port (130), thereby optically separating the output port (130) from the input port (140). The constriction element (140) further comprises a reflective element (142) arranged at the backside (112) of the translucent membrane (110). The reflective element (142) faces towards the reflective layer (114) at a vertical distance D therefrom, thereby defining a probing region (116). Light travelling from the input port (120) to the output port (130) is confined to pass through the probing region (116), wherein at least the probing region (116) comprises pores (118) extending from respective openings at the sensor surface into the translucent membrane (110). A further aspect relates to sensor assembly (101) comprising a sensor element (101) integrated with a sample chamber (102).
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
The present disclosure relates to a sensor device, comprising: a measurement chamber having at least a first wall, the measurement chamber including a plurality of analyte sensors; wherein the measurement chamber allows a fluid to be analyzed to interact with each of the plurality of analyte sensors when the fluid is accommodated within the measurement chamber; the measurement chamber having an inlet configured to receive the fluid to be analyzed and an outlet configured to allow the fluid to exit the measurement chamber after having interacted with the plurality of analyte sensors; the measurement chamber defining a sample volume for accommodating the fluid to be analyzed, the sample volume extending at least between the inlet and the outlet; a heating element configured to heat the fluid accommodated within the measurement chamber.
The present invention provides a syringe for obtaining a target volume of a liquid, in particular blood. The syringe provides a piston with a seal having a width that is identical to the volume line indicating the target full volume of the syringe. This offers a precise and an intuitive way for the end user to understand how much blood is recommended to be drawn from the patient. In exemplary embodiments these visual indicators have the same colour and a desired amount of interruptions of the line of the volume scale are provided.
The present invention relates to blood sampler and the preparation of blood samples that can be used for not only for blood gas, basic metabolic panel parameter analysis but also for a platelet count and/or white blood count, such as a 3-diff or 5-diff. The blood samples comprise at least one anticoagulant for the determination of blood gas and basic metabolic panel parameters and at least one anti-platelet agent.
G01N 1/38 - Diluting, dispersing or mixing samples
G01N 33/80 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood groups or blood types
G01N 33/86 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood coagulating time
The present invention relates to a sensor assembly for body fluids. The sensor assembly includes a measurement chamber having side walls and top and bottom walls, each of the walls having a respective wall wettability for aqueous solutions; a first sensor adapted to measure a first parameter of body fluids, having a surface having a first wettability for aqueous solutions exposed to the measurement chamber at a first axial position, and a second sensor adapted to measure a second parameter of body fluids, having a surface having a second wettability for aqueous solutions higher than the first wettability exposed to the measurement chamber at a second axial position upstream or downstream from the first axial position. At the second axial position, the chamber width exceeds the width of the second sensor surface, and the measurement chamber has a widening in a horizontal direction as compared to the first axial position.
The present invention relates to methods for determining a blood gas parameter and/or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and/or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.
The present invention relates to methods for determining a blood gas parameter and/or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and/or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.
The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201). The method comprises steps of: filling the measurement chamber with a fluid sample; applying a stimulus to the luminophor in the sensor layer; detecting luminescence emitted from the luminophor in the sensor layer in response to the stimulus as a function of time; obtaining a time sequence of measurement values for the detected luminescence; based on the time sequence, determining an actual value of a first parameter and an actual value of a second parameter, wherein one of the first and second parameters is sensitive to a change in refractive index across the interface between the sensor layer and the measurement chamber, and wherein the other one of the first and second parameters is not sensitive to said change in refractive index across the interface between the sensor layer and the measurement chamber; developing an expected value for the second parameter based on the actual value of the first parameter; comparing the expected value for the second parameter to the actual value of the second parameter; and determining the presence (or absence) of a contaminant based on the comparison. In a further aspect, a sample analyzer configured for detecting contaminants in the measurement chamber using embodiments of the above method is provided.
patents
