Biomarkers of hypertension are described for use in diagnosis, prognosis and to support standard inflatable cuff measurements for improved blood pressure measurement certainty.
An apparatus for assaying one or more lateral flow test devices. The apparatus comprises at least one support device for supporting one or more lateral flow test devices in use and at least one sample receptacle configured to receive, in use, a respective liquid sample to be dispensed onto a corresponding lateral flow test device. The apparatus further comprises a dispensing apparatus configured to dispense a known volume of the received liquid sample from the sample receptacle onto the corresponding lateral flow test device supported by the support device.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
A method of monitoring and controlling the processing of biological samples, the method comprising the steps of: receiving (101) a plurality of sample containers, each containing biological material; assigning (102) a priority to each of the sample containers; queueing (103) the sample containers for analysis based on the assigned priorities; extracting (104) a biological sample from each of the plurality of sample containers based on said sample container's position in the queue; analysing (105) each biological sample; providing (106) either a valid result or an inconclusive result for each of the biological samples based on said analysing; for each biological sample for which an inconclusive result has been provided, assigning (109) a new priority to the respective sample container and repeating the queueing, extracting, analysing, and providing steps.
Haematuria is a considerable burden within primary and secondary care; too many haematuria patients are referred to secondary care for invasive and expensive investigations that could be managed in primary care. The current invention has identified biomarker combinations with utility for the diagnosis of bladder cancer in males. Using gender specific biomarker algorithms in combination with clinical risks that are associated with bladder cancer, would allow clinicians to better manage haematuria patients in primary care setting.
A method of supporting diagnostic decisions based on biochemical measurements is presented. The use of a correction factor derived from population biochemical measurement values when applied to a follow-on biochemical measurement value of an individual mitigates pre-analytical and analytical variation enabling more robust clinical analyses and decisions to be made.
G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
G16H 50/00 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into ‘low’ and ‘high’ risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.
Methods are described for the biomarker-based identification of a change in the amount of visceral adipose tissue (VAT) in individuals with a healthy BMI and a healthy waist circumference. The early identification of VAT changes using commonly measured clinical biomarkers when incorporated with exercise and nutritional advice enables the expeditious implementation of the END approach (Exercise Nutrition & Diagnostics) to manage the burgeoning overweight and obesity pandemic.
There is provided an apparatus and method for extracting a biological sample from a sample container. The apparatus comprising: a holder arranged in use to support a sample container; an extractor moveable in use between a first position disengaged from the container when the container is supported by the holder and a second position engaged with the container when the container is supported by the holder, the extractor being arranged in use to obtain matter from the container when in the second position; and an imager arranged in use to capture an image of the extractor at the first position when the extractor is moved from the second position to the first position and to identify, based on analysis of the captured image, when sample is present outside the container.
There is provided a vision system for assessing defects on biochips and a corresponding method. The vision system comprises an imaging region in which a biochip sheet including at least one biochip is locatable in use: an imager arranged in use to image at least a portion of the imaging region, wherein, when the biochip sheet is located in the imaging region. the portion includes at least a face of the biochip sheet: and an illumination source arranged in use to direct illumination on to the face the biochip sheet. thereby illuminating defects on the at least one biochip when a mask material layer is present on the at least one biochip and when a mask material is absent and allowing the defects to be included in the imaged at least a portion of the imaging region.
The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.
The present disclosure describes personalised healthcare methods and systems that gauge the impact of prescribed and over-the-counter medication on the biological systems of individuals by measuring standard clinical biomarkers.
The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.
There is provided a bracket for a biological sample analyser. The bracket comprises abase and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.
01 - Chemical and biological materials for industrial, scientific and agricultural use
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10 - Medical apparatus and instruments
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Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry, except fungicides, herbicides, insecticides, and parasiticides; Diagnostic preparations for scientific purposes; Chemical reagents, other than for medical or veterinary purposes; Enzymes and proteins for industrial use; Diagnostic preparations for analysis of food products and water for scientific and research purposes; Clinical diagnostics preparations for scientific use; Diagnostic scanning agents for scientific use; Diagnostic testing materials for scientific use; Replacement parts and fittings for all the aforesaid goods Pharmaceutical, veterinary and sanitary preparations and substances for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use; blood sera and blood anti-sera, for medical and veterinary use; diagnostic preparations for medical purposes; diagnostic preparations and substances for medical and veterinary purposes; kits for medical purposes comprised of pharmaceutical preparations for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use; clinical diagnostics preparations, for medical or veterinary use; clinical diagnostic reagents for in vitro and vivo use; diagnostic scanning agents for in vivo use; diagnostic testing materials for medical and veterinary use; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; replacement parts and fittings for all the aforesaid goods Medical diagnostic kits, consisting of containers, analyzers and disposable cartridges, namely, apparatus for processing, testing and analyzing of bodily fluids; medical diagnostic kits, consisting of containers, analyzers and disposable cartridges, namely, apparatus for testing or detecting sexually transmitted infections (STI); clinical laboratory analytical instruments for medical or veterinary use, namely, for the analysis of bodily fluids, for use in in vitro diagnostic testing procedures, and for use with clinical chemistry analyzers, blood testing apparatus, and diagnostic saliva vials Medical services; hygienic and beauty care for human beings; consulting services relating to health care; health advice and information services; medical care services; health clinic services; healthcare services; medical consultations and lifestyle consultations, namely, professional consultations to individuals to assess their personal health and wellbeing; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health care matters; professional consultancy relating to health; medical testing; medical diagnostic testing; nursing services; nursing care services; medical health and fitness assessment services; medical advisory and consultancy services relating to immunology; advisory and consultancy services relating to nutrition; cholesterol testing; genetic testing for medical purposes; hearing tests; services for the testing of blood; services for the testing of sera; services for the testing of urine; services for testing of bone functions; services for testing of major body organs; services for the testing of fertility hormone levels; health screening for pregnant women; pregnancy testing; prenatal care services; postnatal care services; services for the testing of diabetes; services for the testing of thyroid function; services for testing iron levels; medical assistance; medical clinics; information, consultancy and advice relating to any of the aforesaid services
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10 - Medical apparatus and instruments
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Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry, except fungicides, herbicides, insecticides, and parasiticides; Diagnostic preparations for scientific purposes; Chemical reagents, other than for medical or veterinary purposes; Enzymes and proteins for industrial use; Diagnostic preparations for analysis of food products and water for scientific and research purposes; Clinical diagnostics preparations for scientific use; Diagnostic scanning agents for scientific use; Diagnostic testing materials for scientific use; Replacement parts and fittings for all the aforesaid goods Pharmaceutical, veterinary and sanitary preparations and substances for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use; blood sera and blood anti-sera, for medical and veterinary use; diagnostic preparations for medical purposes; diagnostic preparations and substances for medical and veterinary purposes; kits for medical purposes comprised of pharmaceutical preparations for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use; clinical diagnostics preparations, for medical or veterinary use; clinical diagnostic reagents for in vitro and vivo use; diagnostic scanning agents for in vivo use; diagnostic testing materials for medical and veterinary use; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; replacement parts and fittings for all the aforesaid goods Medical diagnostic kits, consisting of containers, analyzers and disposable cartridges, namely, apparatus for processing, testing and analyzing of bodily fluids; medical diagnostic kits, consisting of containers, analyzers and disposable cartridges, namely, apparatus for testing or detecting sexually transmitted infections (STI); clinical laboratory analytical instruments for medical or veterinary use, namely, for the analysis of bodily fluids, for use in in vitro diagnostic testing procedures, and for use with clinical chemistry analyzers, blood testing apparatus, and diagnostic saliva vials Medical services; hygienic and beauty care for human beings; consulting services relating to health care; health advice and information services; medical care services; health clinic services; healthcare services; medical consultations and lifestyle consultations, namely, professional consultations to individuals to assess their personal health and wellbeing; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health care matters; professional consultancy relating to health; medical testing; medical diagnostic testing; nursing services; nursing care services; medical health and fitness assessment services; medical advisory and consultancy services relating to immunology; advisory and consultancy services relating to nutrition; cholesterol testing; genetic testing for medical purposes; hearing tests; services for the testing of blood; services for the testing of sera; services for the testing of urine; services for testing of bone functions; services for testing of major body organs; services for the testing of fertility hormone levels; health screening for pregnant women; pregnancy testing; prenatal care services; postnatal care services; services for the testing of diabetes; services for the testing of thyroid function; services for testing iron levels; medical assistance; medical clinics; information, consultancy and advice relating to any of the aforesaid services
01 - Chemical and biological materials for industrial, scientific and agricultural use
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10 - Medical apparatus and instruments
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Chemicals for use in industry, science and photography, as
well as in agriculture, horticulture and forestry;
diagnostic preparations for scientific purposes; chemical
reagents; enzymes and proteins; diagnostic preparations for
analysis of food products and water; diagnostic testing
materials. Pharmaceutical, veterinary and sanitary preparations and
substances; sera and anti-sera; diagnostic preparations and
substances for medical and veterinary purposes; clinical
diagnostic reagents for medical or veterinary use; clinical
diagnostic reagents for in vitro and/or vivo use; diagnostic
scanning agents for in vivo use; diagnostic testing
materials for medical and veterinary use; clinical
laboratory analytical instruments; clinical medical
reagents; reagents for use in diagnostic tests for medical
and veterinary purposes; reagents for use with analyzers for
medical and veterinary purposes; clinical diagnostic
reagents; diagnostic scanning agents; diagnostic kits for
medical purposes. Medical apparatus and instruments; diagnostic apparatus and
instruments for medical use; diagnostic imaging apparatus
for medical use; clinical analyzers for medical and
veterinary use; diagnostic testing apparatus and instruments
for use in immunoassay procedures; detectors and diagnostic
testing apparatus and instruments for use in immunoassay
procedures; parts and fittings for all the aforesaid goods;
clinical laboratory analytical instruments for medical or
veterinary use. Medical services; hygienic and beauty care for human beings;
consulting services relating to health care; health advice
and information services; medical care services; health
clinic services; healthcare services; medical consultations
and lifestyle consultations, namely, professional
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and wellbeing [health]; medical health assessment services;
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services.
Methods and products for adjusting the chronological age of a biological system or an individual to provide finer scale insight to health status are provided. The methods are underpinned by various serum and urinary biomarkers including antistreptolysin.
The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
19.
POXVIRUS ENCODING A BINDING AGENT COMPRISING AN ANTI- PD-L1 SDAB
The present invention concerns a novel poxvirus comprising a nucleic acid molecule inserted in its genome and encoding a binding agent, wherein the binding agent comprises or consists essentially of, or consists of, a single domain antibody (sdAb) specifically binding to programmed death-ligand 1 (PD-L1). The present invention also concerns a method for producing the poxvirus of the invention. The invention further relates to a composition, in particular a pharmaceutical composition, comprising, or consisting essentially of, the poxvirus according to the invention, in particular a therapeutically effective amount of the poxvirus according to the invention. Moreover, the invention also relates to therapeutic uses or methods of treatment using the poxvirus or composition according to the invention, or any combination thereof, in particular in the treatment or prevention of a proliferative disease, such as cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present invention is related to a fusion polypeptide comprising a single domain antibody (sdAb) specifically binding to programmed death-ligand 1 (PD-L1) fused to a member of the Tumor Necrosis Factor superfamily of ligands (TNFSF), to a nucleic acid molecule encoding it, a vector comprising such nucleic acid molecule, a host cell comprising such nucleic acid molecule or vector, compositions comprising any one of them or combinations thereof, methods for their production, as well as to therapeutic uses and methods of treatment using them.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Methods of diagnosing type 2 diabetes mellitus and diabetic nephropathy are described that make use of a combination of biomarkers chosen from sTNFR1, H-FABP, midkine, cystatin C, sTNFR2 and L-FABP.
The current invention provides biomarkers and combinations thereof for the diagnosis and prognosis of inflammatory liver disease. Methods include the biomarkers suppression of tumorigenicity 2 receptor (ST2), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor alpha (TNFα) and Procollagen III N-terminal peptide (P3NP).
The current invention provides methods to improve inter-assay precision in glycosylation assays and which can also be applied to point-of-care situations. The methods can be enabled in the form of substrates onto which are immobilised capture probes and glycan standards. The methods can be applied in cancer diagnosis.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
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Medical services; hygienic and beauty care for human beings; consulting services relating to health care; health advice and information services; medical care services; health clinic services; healthcare services; medical consultations and lifestyle consultations, namely, professional consultations to individuals to assess their personal health and wellbeing [health]; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health care matters; professional consultancy relating to health; medical testing; diagnostic testing; nursing services; nursing care services; medical health and fitness assessment services; advisory and consultancy services relating to immunology; advisory and consultancy services relating to nutrition; cholesterol testing; genetic testing for medical purposes; hearing tests; services for the testing of blood; services for the testing of sera; services for the testing of urine; services for testing of bone functions; services for testing of major body organs; services for the testing of fertility hormone levels; health screening for pregnant women; pregnancy testing; prenatal care services; postnatal care services; services for the testing of diabetes; services for the testing of thyroid function; services for testing iron levels; medical assistance; medical clinics; information, consultancy and advice relating to any of the aforesaid services.
APOE, LSRAPOE, LSR and VEGF-A-related variants and the risk of development of AD, involving novel molecular mechanisms and interactions that highlight the importance of these molecules as biomarkers for AD. A prediction model is further proposed, including nine genetic variants which appear to strongly influence the risk for AD.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
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(1) Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; diagnostic preparations for scientific purposes; chemical reagents; enzymes and proteins; diagnostic preparations for analysis of food products and water; diagnostic testing materials.
(2) Pharmaceutical, veterinary and sanitary preparations and substances; sera and anti-sera; diagnostic preparations and substances for medical and veterinary purposes; clinical diagnostic reagents for medical or veterinary use; clinical diagnostic reagents for in vitro and/or vivo use; diagnostic scanning agents for in vivo use; diagnostic testing materials for medical and veterinary use; clinical laboratory analytical instruments; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; clinical diagnostic reagents; diagnostic scanning agents; diagnostic kits for medical purposes.
(3) Medical apparatus and instruments; diagnostic apparatus and instruments for medical use; diagnostic imaging apparatus for medical use; clinical analyzers for medical and veterinary use; diagnostic testing apparatus and instruments for use in immunoassay procedures; detectors and diagnostic testing apparatus and instruments for use in immunoassay procedures; parts and fittings for all the aforesaid goods; clinical laboratory analytical instruments for medical or veterinary use. (1) Medical services; hygienic and beauty care for human beings; consulting services relating to health care; health advice and information services; medical care services; health clinic services; healthcare services; medical consultations and lifestyle consultations, namely, professional consultations to individuals to assess their personal health and wellbeing [health]; medical health assessment services; health screening services; diagnostic health screening services; preparation of reports relating to health care matters; professional consultancy relating to health; medical testing; medical diagnostic services [testing and analysis]; nursing services; nursing care services; medical health and fitness assessment services; advisory and consultancy services relating to immunology; advisory and consultancy services relating to nutrition; cholesterol testing; genetic testing for medical purposes; hearing tests; services for the testing of blood; services for the testing of sera; services for the testing of urine; services for testing of bone functions; services for testing of major body organs; services for the testing of fertility hormone levels; health screening for pregnant women; pregnancy testing; prenatal care services; postnatal care services; services for the testing of diabetes; services for the testing of thyroid function; services for testing iron levels; medical assistance; medical clinics; information, consultancy and advice relating to any of the aforesaid services.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry, except fungicides, herbicides, insecticides, and parasiticides; diagnostic preparations for scientific purposes; chemical reagents, other than for medical or veterinary purposes; enzymes and proteins for industrial use; diagnostic preparations for analysis of food products and water for scientific and research purposes; diagnostic testing materials in the nature diagnostic reagents for scientific use Pharmaceutical, veterinary and sanitary preparations and substances for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use blood sera and blood anti-sera, for medical and veterinary use; diagnostic preparations and substances for medical and veterinary purposes; clinical diagnostic reagents for medical or veterinary use; clinical diagnostic reagents for medical and veterinary use in vitro and/or vivo use; diagnostic scanning agents for medical and veterinary use for in vivo use; diagnostic testing materials for medical use in the detection and monitoring of disease states in vitro, namely, chemical reagents for medical and veterinary use; clinical laboratory analytical instruments in the nature of clinical medical reagents; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; clinical medical diagnostic reagents; diagnostic scanning agents, for medical purposes; diagnostic kits for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use for medical purposes Medical apparatus and instruments for medical use, namely, for use in vitro diagnostic testing procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins and hormones; diagnostic apparatus and instruments for medical use use in vitro diagnostic testing procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs; diagnostic imaging apparatus for medical use; clinical analyzers for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs for medical and veterinary use; diagnostic testing apparatus and instruments for use in immunoassay procedures, namely, for use in the measurement of antibodies, immunoglobulins, hormones and drugs representing various drug classes; detectors and diagnostic testing apparatus and instruments for use in immunoassay procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs; parts and fittings for all the aforesaid goods, namely, x-ray diagnostic apparatus, ultrasound diagnostic apparatus, probes for use in in vitro diagnostic testing procedures, clinical chemistry analyzers, blood testing apparatus; clinical laboratory analytical instruments in the nature x-ray diagnostic apparatus, ultrasound diagnostic apparatus, probes for use in in vitro diagnostic testing procedures, clinical chemistry analyzers, blood testing apparatus, diagnostic saliva vials, all being clinical laboratory analytical instruments for medical or veterinary use Medical services; hygienic and beauty care for human beings; consulting services relating to health care; health advice and information services; medical care services in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function; health clinic services; healthcare services; medical consultations and lifestyle consultations, namely, professional consultations to individuals to assess their personal health and health wellbeing [health]; medical health assessment services; health screening services in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function; diagnostic health screening services in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function; providing medical information to patients in the form of preparation of reports in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function relating to health care matters; professional consultancy relating to health; medical testing; testing and analysis in the nature of medical diagnostic services [testing and analysis]; nursing services; nursing care services; medical health and fitness assessment services, for medical purposes; medical advisory and consultancy services relating to immunology; advisory and consultancy services relating to nutrition; cholesterol testing; genetic testing for medical purposes; hearing tests; services for the testing of blood, for medical purposes; services for the medical testing of blood sera; services for the medical testing of urine; 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29.
REACTIVE ALDEHYDE BIOMARKERS OF TYPE 2 DIABETES AND DIABETIC NEPHROPATHY
An apparatus for assaying one or more lateral flow test devices. The apparatus comprises at least one support device for supporting one or more lateral flow test devices in use and at least one sample receptacle configured to receive, in use, a respective liquid sample to be dispensed onto a corresponding lateral flow test device. The apparatus further comprises a dispensing apparatus configured to dispense a known volume of the received liquid sample from the sample receptacle onto the corresponding lateral flow test device supported by the support device.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A method is described for the identification of individuals with a BMI of less than 25 who have a biochemical profile that corresponds to an overweight or obese phenotype. The method of highlighting this hidden obesity makes use of various biomarker combinations that can incorporate various analytes including leptin and complement C3.
A method of monitoring and controlling the processing of biological samples, the method comprising the steps of: receiving (101) a plurality of sample containers, each containing biological material; assigning (102) a priority to each of the sample containers; queueing (103) the sample containers for analysis based on the assigned priorities; extracting (104) a biological sample from each of the plurality of sample containers based on said sample container's position in the queue; analysing (105) each biological sample; providing (106) either a valid result or an inconclusive result for each of the biological samples based on said analysing; for each biological sample for which an inconclusive result has been provided, assigning (109) a new priority to the respective sample container and repeating the queueing, extracting, analysing, and providing steps.
Haematuria is a considerable burden within primary and secondary care; too many haematuria patients are referred to secondary care for invasive and expensive investigations that could be managed in primary care. The current invention has identified biomarker combinations with prolactin and/or LASP-1 with utility for the diagnosis of bladder cancer in males. Using gender specific biomarker algorithms in combination with clinical risks that are associated with bladder cancer, would allow clinicians to better manage haematuria patients in primary care setting.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
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Chemicals for use in industry, science and photography, as
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diagnostic preparations for scientific purposes; chemical
reagents; diagnostic preparations for analysis of food
products and water; diagnostic scanning agents for
scientific use; diagnostic testing materials, other than for
medical use; parts and fittings for all the aforesaid goods. Pharmaceutical, veterinary and sanitary preparations and
substances; serums and antitoxic sera; diagnostic
preparations; diagnostic preparations and substances for
medical and veterinary purposes; diagnostics kits comprising
of medical diagnostic reagents; clinical diagnostics, for
medical or veterinary use; clinical diagnostic reagents for
in vitro and/or vivo use; diagnostic scanning agents for in
vivo use; diagnostic testing materials for medical and
veterinary use; clinical medical reagents; reagents for use
in diagnostic tests for medical and veterinary purposes;
reagents for use with analyzers for medical and veterinary
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clinical diagnostics; enzymes for medical purposes. Scientific, nautical, surveying, optical, weighing,
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relating to the analysis, monitoring, research and/or
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arranging and conducting courses, conferences, lectures,
seminars, presentations, teach-ins, events, workshops and
symposiums; planning, arranging and conducting courses,
conferences, lectures, seminars, presentations, teach-ins,
events, workshops and symposiums in the medical and
healthcare fields; providing continuing medical education
courses; organisation of courses using distance learning
methods; instruction and training provided on-line from a
computer database or from facilities provided on the
Internet and other similar information networks; providing
electronic tutorials; publishing services; information,
consultancy and advice relating to any of the aforesaid
services. Scientific and technological services and research and
design relating thereto; design and development of computer
hardware and software; medical research services; clinical
research; analysis of human serum for medical research;
analysis of human tissues for medical research; chemical
laboratory services; chemical analysis; chemical research;
laboratory services for analytical testing; medical
laboratory services; biochemistry research and advisory
services; biological research and advisory services;
computer programming in the medical field; design of medical
apparatus; blood analysis services; development of test
equipment for medical apparatus; research and development
services relating to surgical and medical apparatus and
instruments; quality assessment services for clinical
laboratories; information, consultancy and advice relating
to any of the aforesaid services. Medical services; hygienic and beauty care for human beings;
consulting services relating to health care; health advice
and information services; medical care services; health
clinic services; healthcare services; medical consultations
and lifestyle consultations, namely, professional
consultations to individuals to assess their personal health
and wellbeing [health]; medical health assessment services;
health screening services; diagnostic health screening
services; preparation of reports relating to health care
matters; professional consultancy relating to health;
medical testing; medical diagnostic testing; nursing
services; nursing care services; medical health and fitness
assessment services; advisory and consultancy services
relating to immunology; advisory and consultancy services
relating to nutrition; cholesterol testing; genetic testing
for medical purposes; hearing tests; services for the
testing of blood; medical serum testing services; services
for the testing of urine; services for testing of bone
functions; services for testing of major body organs;
services for the testing of fertility hormone levels; health
screening for pregnant women; pregnancy testing; prenatal
care services; postnatal care services; services for the
testing of diabetes; services for the testing of thyroid
function; services for testing iron levels; medical
assistance; medical clinics; information, consultancy and
advice relating to any of the aforesaid services.
Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into 'low' and 'high' risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.
Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into 'low' and 'high' risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
35 - Advertising and business services
Goods & Services
Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Diagnostic preparations for scientific purposes; chemical reagents; enzymes and proteins; diagnostic preparations for analysis of food products and water; clinical diagnostics, other than for medical or veterinary use; diagnostic scanning agents; diagnostic testing materials; clinical diagnostic reagents for in vitro and/or vivo use; diagnostic scanning agents for in vivo use; parts and fittings for all the aforesaid goods. Pharmaceutical, veterinary and sanitary preparations and substances; antitoxic sera; diagnostic preparations; diagnostic preparations and substances for medical and veterinary purposes; clinical diagnostics, for medical or veterinary use; diagnostic testing materials for medical and veterinary use; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; parts and fittings for all the aforesaid goods. Scientific, nautical, surveying, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; data processing equipment and computers; computer software and computer programs; computer software and computer programs for or relating to the analysis, monitoring, research and/or reporting of clinical data; computer databases relating to the analysis, monitoring, research and/or reporting of clinical data; computer hardware and computer systems for or relating to the analysis, monitoring, research and/or reporting of clinical data; electronic publications relating to the analysis, monitoring, research and/or reporting of clinical data; scientific and optical apparatus and instruments for or relating to the analysis, monitoring, research and/or reporting of clinical data; diagnostic imaging apparatus, other than for medical use; clinical laboratory analytical instruments, other than for medical use; downloadable electronic publications; parts and fittings for all the aforesaid goods. Medical diagnostic kits for the testing of samples including serum, plasma urine, cerebrospinal fluid and blood; clinical laboratory analytical instruments for medical or veterinary use; clinical laboratory analytical instruments; medical apparatus and instruments; diagnostic apparatus and instruments for medical use; diagnostic imaging apparatus for medical use; clinical chemistry analyzers for medical and veterinary use; diagnostic testing apparatus and instruments for use in immunoassay procedures; analysers for medical use; diagnostic test kits for medical purposes. Retail and wholesale services for drugs for pharmaceutical purposes; retail and wholesale services for medical supplies; retail and wholesale services for pharmaceutical preparations.
There is provided an apparatus and method for extracting a biological sample from a sample container. The apparatus comprising: a holder arranged in use to support a sample container; an extractor moveable in use between a first position disengaged from the container when the container is supported by the holder and a second position engaged with the container when the container is supported by the holder, the extractor being arranged in use to obtain matter from the container when in the second position; and an imager arranged in use to capture an image of the extractor at the first position when the extractor is moved from the second position to the first position and to identify, based on analysis of the captured image, when sample is present outside the container.
There is provided a vision system for assessing defects on biochips and a corresponding method. The vision system comprises an imaging region in which a biochip sheet including at least one biochip is locatable in use; an imager arranged in use to image at least a portion of the imaging region, wherein, when the biochip sheet is located in the imaging region, the portion includes at least a face of the biochip sheet; and an illumination source arranged in use to direct illumination on to the face the biochip sheet, thereby illuminating defects on the at least one biochip when a mask material layer is present on the at least one biochip and when a mask material is absent and allowing the defects to be included in the imaged at least a portion of the imaging region.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Scientific, nautical, surveying, optical, weighing,
measuring, signalling, checking (supervision), life-saving
and teaching apparatus and instruments; apparatus for
recording, transmission or reproduction of sound or images;
magnetic data carriers, recording discs; DVDs; data
processing equipment and computers; computer software and
computer programs for or relating to the analysis,
monitoring, research and/or reporting of medical and
clinical data; computer databases relating to the analysis,
monitoring, research and/or reporting of medical and
clinical data; computer hardware and computer systems for or
relating to the analysis, monitoring, research and/or
reporting of medical and clinical data; electronic
publications relating to the analysis, monitoring, research
and/or reporting of medical and clinical data; scientific
and optical apparatus and instruments for or relating to the
analysis, monitoring, research and/or reporting of medical
and clinical data; diagnostic imaging apparatus, other than
for medical use; downloadable electronic publications; parts
and fittings for all the aforesaid goods. Scientific and technological services and research and
design relating thereto; design and development of computer
hardware and software; medical research services; clinical
research; analysis of human serum for medical research;
analysis of human tissues for medical research; chemical
laboratory services; chemical analysis; chemical research;
laboratory services for analytical testing; medical
laboratory services; biochemistry research and advisory
services; biological research and advisory services;
computer programming in the medical field; design of medical
apparatus; blood analysis services; development of test
equipment for medical apparatus; research and development
services relating to surgical and medical apparatus and
instruments; information and advice relating to any of the
aforesaid services. Medical services; hygienic and beauty care for human beings;
consulting services relating to health care; health advice
and information services; medical care services; health
clinic services; healthcare services; medical consultations
and lifestyle consultations, namely, professional
consultations to individuals to assess their personal health
and wellbeing [health]; medical health assessment services;
health screening services; diagnostic health screening
services; preparation of reports relating to health care
matters; professional consultancy relating to health;
medical testing; medical diagnostic services [testing and
analysis]; nursing services; nursing care services; medical
health and fitness assessment services; medical consultancy
and advisory services relating to immunology; advisory and
consultancy services relating to nutrition; cholesterol
testing; genetic testing for medical purposes; hearing
tests; services for the testing of blood; medical serum
testing services; services for the testing of urine;
services for testing of bone functions; services for testing
of major body organs; services for the testing of fertility
hormone levels; services for the testing of diabetes;
services for the testing of thyroid function; medical
testing of iron levels; medical assistance; medical clinics;
advice, information and consultancy services for all of the
aforesaid services.
The current invention provides a multiplex method for screening bovine samples for antibodies against several important pathogens. These pathogens include Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpesvirus-1 (BoHV-1), Mycobacterium paratuberculosis (MAP), Leptospira species, Neospora caninum and Fasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.
The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.
The present invention relates to a method of detecting the presence of an antibody in a samples obtained from a subject, wherein said antibody has affinity for a coronavirus antigen, or portion thereof. The present invention also relates to a substrate having immobilised on its surface said coronavirus antigen and methods for producing said substrate.
The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.
There is provided a bracket for a biological sample analyser. The bracket comprises a base and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Chemicals for use in industry, science and photography, chemicals for use in agriculture, horticulture and forestry except fungicides, herbicides, insecticides and parasiticide; diagnostic preparations for scientific purposes; chemical reagents for non-medical purposes, namely, for use in evaluating disease states in vitro for laboratory research purposes; diagnostic preparations for analysis of food products and water for scientific or research use; diagnostic reagents and preparations, except for medical or veterinary use, namely, diagnostic scanning agents for scientific use; diagnostic preparations for scientific or research use other than for medical use, namely, diagnostic testing materials; parts and fittings for all the aforesaid goods Pharmaceutical preparations and substances for use in medical clinical analysis and testing in connection with diagnosing cardiovascular diseases, coronary heart disease, brain diseases, cancer, diabetes, kidney diseases, renal diseases, anemia, dementia, nervous system dysfunctions, diseases of the central nervous system, autoimmune diseases, allergy, vascular diseases, infertility, menopause, early or delayed puberty, reproductive or non-reproductive disorders, gastrointestinal disorders, digestive diseases and conditions, metabolic diseases, hypercalcemia, thyroid diseases, bone disorders, respiratory diseases, infectious diseases, sexually transmitted diseases, and urinary tract infections, testing high or low levels of testosterone, testing for calcium absorption, testing of blood levels, antimicrobial testing, and screening for drug use; veterinary preparations and substances for testing of honey, egg, tissue, urine, feed and milk; Sanitary preparations and substances, namely, sterilizing preparations and disinfectants; blood serums and antitoxic sera for medical purposes; antitoxic sera; diagnostic preparations for medical and veterinary purposes; diagnostic preparations and substances for medical and veterinary purposes; diagnostic kits comprised of medical diagnostic reagents for testing of bodily fluids for use in disease states detection, namely, cardiac, stroke, metabolic, cancer, diabetes, fertility, thyroid and DNA arrays; clinical diagnostic preparations for medical or veterinary use; chemical diagnostic reagents for medical purposes, namely, clinical diagnostic reagents for in vitro and/or vivo use; diagnostic scanning agents for medical use, namely, diagnostic scanning agents for in vivo use; diagnostic testing materials for medical and veterinary use, namely, reagents for use in medical genetic testing and veterinary genetic testing; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; structural parts and fittings for all the aforesaid; clinical diagnostic preparations for medical purposes; enzymes for medical purposes Scientific and optical apparatus and instruments, namely, a benchtop analytical system composed of barcode scanner and associated software for reading barcodes, a chemiluminescent detection system in the nature of instruments for measuring chemiluminescence, a temperature controlled incubator for laboratory use, and an electronic reagent and patient sample dispenser, suitable for protein and DNA arrays for or relating to the analysis, monitoring, research and/or reporting of clinical data, for use in vitro diagnostic testing procedures for clinical, veterinary, food and toxicological analysis; data processing equipment and computers; downloadable computer software and computer programs for use in conjunction with in vitro diagnostic testing apparatus, namely, software for controlling medical and clinical sample processing, sample result reporting and test apparatus system robotics; downloadable computer software and computer programs for use in providing analysis, monitoring, research and reporting of clinical data; electronic database in the field of analysis, monitoring, research and reporting of clinical data, recorded on computer media; computer hardware and computer systems comprised primarily of computer hardware and also including recorded computer software for use in providing analysis, monitoring, research and reporting of clinical data; downloadable electronic publications, namely, books, blogs, articles, newsletters in the field of analysis, monitoring, research and reporting of clinical data scientific apparatus and instruments for scientific use relating to the analysis, monitoring, research and reporting of clinical data; optical apparatus and instruments, namely, optical sensors relating to the analysis, monitoring, research and reporting of clinical data; electronic diagnostic imaging apparatus, other than for medical use, for the study of chemical compounds and structures; clinical laboratory analytical instruments for the testing of clinical chemistry, toxicology, food and wine, other than for medical use; downloadable electronic publications in the nature of books, blogs, articles, newsletters in the field of diagnostics; structural parts and fittings for all the aforesaid goods clinical laboratory analytical instruments for medical diagnostic and treatment and veterinary purposes, namely, x-ray diagnostic apparatus, ultrasound diagnostic apparatus, probes for use in in vitro diagnostic testing procedures, clinical chemistry analyzers, blood testing apparatus, diagnostic saliva vials; clinical laboratory analytical instruments for medical diagnostic and treatment purposes, namely, x-ray diagnostic apparatus, ultrasound diagnostic apparatus, probes for use in in vitro diagnostic testing procedures, clinical chemistry analyzers, blood testing apparatus, diagnostic saliva vials Educational services, namely, conducting programs in the field of scientific research and diagnostics; providing training in the field of scientific research and diagnostics; planning, arranging and conducting courses, conferences, lectures, seminars, presentations, teach-in lectures, events, workshops and symposiums in the medical and healthcare fields; providing continuing medical education courses; organization of courses in the field of scientific research and diagnostics using distance learning methods; providing on-line courses of instruction in the field of scientific research and diagnostics being a type of instruction and training provided on-line from a computer database or from facilities provided on the Internet and other similar information networks; providing on-line tutorial videos in the field of scientific research and diagnostics, not downloadable; publishing of books, reviews, articles, magazines in the field of scientific research and diagnostics; advice, information and consultancy services for all of the aforesaid services Scientific and technological services, namely, scientific and technological analysis in the field of medicine and diagnostics and research and design relating thereto; design and development of computer hardware and software; medical research services; clinical research in the field of diagnostics; medical research, namely, analysis of human serum for medical research; medical research, namely, analysis of human tissue for medical research; chemical laboratory services; chemical analysis; chemical research; scientific laboratory services for analytical testing; medical laboratory services; biochemistry research; technology advisory services related to biochemistry research; biological research; technology advisory services related to biological research; computer programming in the medical field; design of medical apparatus; blood analysis services; development of test equipment for medical apparatus; research and development services relating to surgical and medical apparatus and instruments; providing quality assessment services being quality assurance services for clinical laboratories in the field of biochemistry; information, consultancy and advice relating to any of the aforesaid services Medical services; hygienic and beauty care for human beings; consultancy services relating to health care; health advice and information services; medical care services; health clinic services; health care services; medical consultations and lifestyle consultations, namely, professional medical consultations to individuals to assess their personal health and well-being; medical health assessment services; health screening services in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function; diagnostic health screening services in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function; medical reporting services, namely, preparation of reports relating to health care matters; professional consultancy relating to health; medical testing for diagnostic or treatment purposes in the field of general health, immunology, nutrition, cardiac diseases, metabolism, cancer, diabetes, fertility, thyroid function; medical diagnostic testing; nursing services; nursing care services; health assessment services, namely, medical health and fitness assessment services; providing medical consultancy and advisory services relating to immunology; consultancy and advisory services relating to nutrition; medical testing for diagnostic or treatment purposes in the field of cholesterol; genetic testing for medical purposes; providing hearing testing services; medical testing of blood; medical testing for diagnostic or treatment purposes of medical serums; medical testing of urine; medical testing for diagnostic or treatment purposes of bone functions; medical diagnostic testing services for the testing of major body organs, namely, heart, brain, lungs, kidneys, liver; medical diagnostic testing services for the testing of fertility hormone levels; health screening for pregnant women; pregnancy testing; health care services, namely, prenatal care services; postnatal care services, in the nature of deficiency diagnostics and personalised health plans; medical diagnostic testing services for the testing of diabetes; medical diagnostic testing services for the testing of thyroid function; medical diagnostic testing services, namely, medical testing of iron levels; medical assistance; medical clinics; advice, information and consultancy services for all of the aforesaid services
49.
PHARMACEUTICAL PROFILER ARRAY FOR USE IN PERSONALISED HEALTHCARE
Preventative healthcare products and processes are described. Point-of-care analysis of prescribed and OTC pharmaceuticals in biological samples of an individual using a pharmaceutical profiler array supports drug-management by gauging drug efficacy and toxicity.
A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.
Herein we have identified a protein signature that is easily measured in blood and urine and highly predictive of bladder cancer (BC) risk in Type 2 Diabetes Mellitus (T2DM) patients. This biomarker model could be applied to screen T2DM patients presenting with haematuria for BC in diabetes clinics. Earlier urology referral of T2DM patients will improve outcomes for these patients.
A holder for holding pipette tips of a molecular diagnostics assay analyser comprises a frame comprising a plurality of bores which are separated from each other, each bore configured to removably hold a first end of a pipette tip and a drip tray spaced apart from the plurality of bores, the drip tray configured to receive a second end of a pipette tip when said pipette tip is held by one of the plurality of bores, thereby allowing the pipette tip to be placed in the holder for re-use.
Methods and products for adjusting the chronological age of a biological system or an individual to provide finer scale insight to health status are provided. The methods are underpinned by various serum and urinary biomarkers including antistreptolysin.
There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.
There is provided a sterilisation assembly for a molecular diagnostic assay analyse. The assembly comprising: an enclosure having a passage therethrough, the passage being arranged in use to allow an assay sample set to pass through the enclosure, the enclosure defining a barrier adapted in use to restrict fluid communication across the enclosure to communication through the passage; and a decontaminator located within the passage, the decontaminator is arranged in use to sterilise contamination in the passage.
The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
An assay cartridge for use in a molecular diagnostics assay having an assay region; a first end comprising a first engagement member for engaging with a support housing; and a second end comprising a second engagement member for engaging with a support housing. The second engagement member has a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element. The clip has a release element extending from the resilient element actuatable to release the clip from a caddy in use.
The current invention provides novel methods to isolate and identify coronavirus virions in a sample which are indicative of an active infection, but also, importantly, indicate individuals who are likely to be infectious to others. The methods described herein can be used in isolation as a rapid test or can be integrated into and enhance current viral RNA detection tests.
The present invention provides a method for detecting the presence or risk of bladder cancer in a female patient comprising the steps of detecting the presence of a panel of biomarkers in a sample isolated from a female patient, said panel of biomarkers comprising IL-13 and IL-12p70 and one or more biomarkers selected from BTA, Midkine, PAI-1/tPA, 8OHdG, CEA, CK18, Clusterin, Creatinine, CXCL16, Cystatin B, Cystatin C, d-Dimer, EGF, FAS, HAD, IL-1a, IL-1b, IL-4, IL-6, IL-7, IL-8, MCP-1, Microalbumin, MMP9NGAL, MMP9TIMP1, NGAL, NSE, Progranulin, TUP, TGFB1, Thrombomodulin, sTNFR1, TPA, VEGF and Triglycerides and/or the concentration of albumin/microalbumin/protein and creatinine expressed as an albumin:creatinine ratio in a sample isolated from a female patient; and assessing the results and comparing them to a normal control wherein an elevated presence of the biomarker compared to a normal control indicates the presence or risk of cancer in the patient from whom the sample is isolated.
There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.
A cartridge for polymerase chain reaction, PCR, comprises a vessel for PCR having an opening and a resealable membrane arranged, in use, to cover the opening of the vessel such that the opening of the vessel is vapour tight.
There is provided a cartridge sealing apparatus (1) comprising a sealing head (10) having a sealing surface (12), the sealing head being adapted in use to hold a sealing member (70) against a surface of a cartridge (100) by application of pressure to the sealing member at the sealing surface across a portion of the sealing member, a bonding layer being present between the sealing member and the cartridge thereby causing the sealing member (70) to seal the cartridge when held against the surface of the cartridge; and a cutting edge (20) arranged around the sealing head (10). The cutting edge is configured to move when the sealing member is held against the surface of the cartridge by the sealing head, from an unextended position, in which the cutting edge is located adjacent the sealing head, to an extended position, in which the cutting edge is adapted to cut the sealing member.
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
B65B 7/16 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
B29C 65/00 - Joining of preformed partsApparatus therefor
64.
BIOMARKER OF DRUG-INDUCED CELLULAR TOXICITY AND DEPRESSION
To diagnose a mental disorder, clinicians normally perform a physical examination, a psychological evaluation and use the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) or equivalent classification system. Many critics of the DSM see it as an oversimplification of the vast continuum of human behaviour. The current invention provides biomarker combinations which could be used in conjunction with the DSM or equivalent classification system to support clinical decisions and reduce the potential risk of misdiagnosis or even over-diagnosis of patients.
There is provided a method of classifying a biological status of an individual. The method comprising: obtaining a biological sample from a patient; obtaining health-related information from the patient, said information including patient gender; analysing the sample to identify a quantity of each of 2 or more endogenous analytes in the sample; comparing the analyte quantities to reference data from healthy individuals to classify the patient as healthy, pre-diseased, at risk of disease or diseased for at least one health-related condition. The reference data includes data derived from a group of biological samples of individuals having the same gender as the patient and not having a need for medical treatment for a disease or illness, each biological sample of the group of biological samples having been analysed by the same process as used to analyse the patient sample, the process being monitored to maintain a predetermined level of consistency.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
Mycobacterium paratuberculosisNeospora caninumFasciola hepaticaFasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.
The current invention provides a multiplex method for screening bovine samples for antibodies against several important pathogens. These pathogens include Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpesvirus-1 (BoHV-1), Mycobacterium paratuberculosis (MAP), Leptospira species, Neospora caninum and Fasciola hepatica. This multiplex screening is enabled by substrates with immobilized pathogen antigens and offer multiple advantages for the routine testing of farm animals.
A fluidic card assembly (1) comprises an inlet (20) for introducing a fluid to the fluidic card assembly (1), a turbulent flow portion (30) downstream of the inlet (20), the turbulent flow portion (30) comprising a widening fluid channel (31) whereby a fluid introduced via the inlet (20) channel undergoes turbulence, and a laminar flow portion (40) downstream of the turbulent flow portion (30). The laminar flow portion (40) is configured to allow fluid passing from the turbulent flow portion (30) into the laminar flow portion (40) to establish a laminar flow pattern, and is configured to house a biochip (44) such that a fluid in the laminar flow portion (40) may be in contact with the biochip (44).
A holder for holding pipette tips of a molecular diagnostics assay analyser comprises a frame comprising a plurality of bores which are separated from each other, each bore configured to removably hold a first end of a pipette tip and a drip tray spaced apart from the plurality of bores, the drip tray configured to receive a second end of a pipette tip when said pipette tip is held by one of the plurality of bores, thereby allowing the pipette tip to be placed in the holder for re-use.
A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.
There is provided a sterilisation assembly for a molecular diagnostic assay analyse. The assembly comprising: an enclosure having a passage therethrough, the passage being arranged in use to allow an assay sample set to pass through the enclosure, the enclosure defining a barrier adapted in use to restrict fluid communication across the enclosure to communication through the passage; and a decontaminator located within the passage, the decontaminator is arranged in use to sterilise contamination in the passage.
There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.
An assay cartridge (31) for use in a molecular diagnostics assay comprising: an assay region (32), possibly containing a plurality of reagent wells (34); a first end comprising a first engagement member (35), such as a lip or protrusion, for engaging with a support housing; and a second end comprising a second engagement member (36) for engaging with a support housing; wherein the second engagement member comprises a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element; wherein the clip comprises a release element extending from the resilient element actuatable to release the clip from a caddy or support housing in use.
There is provided a chemiluminescence detector sample enclosure. The enclosure comprises a first interface member forming part of a chemiluminescence detector and having a first sealing element and a second interface member comprising a plurality of sample holders, each sample holder having a second sealing element. The first interface member is engagable with and moveable between sample holder subsets of the plurality of sample holders, engagement with a respective sample holder subset providing engagement of the first interface member with each sample holder of the respective sample holder subset and relative movement of the first and second interface members providing movement between sample holder subsets; and when the first interface member is engaged with each respective sample holder, the first sealing element and the respective second sealing element are adapted to interact so as to form a light restricting seal between the first interface member and said sample holder.
The present invention provides a method for detecting the presence or risk of bladder cancer in a female patient comprising the steps of detecting the presence of a panel of biomarkers in a sample isolated from a female patient, said panel of biomarkers comprising IL-13 and IL-12p70 and one or more biomarkers selected from BTA, Midkine, PAI-1/t PA, 8OHdG, CEA, CK18, Clusterin, Creatinine, CXCL16, Cystatin B, Cystatin C, d-Dimer, EGF, FAS, HAD, IL-1a, IL-1b, IL-4, IL-6, IL-7, IL-8, MCP-1, Microalbumin, MMP9NGAL, MMP9TIMP1, NGAL, NSE, Progranulin, TUP, TGFB1, Thrombomodulin, sTNFR1, TPA, VEGF and Triglycerides and/or the concentration of albumin/microalbumin/protein and creatinine expressed as an albumin:creatinine ratio in a sample i s o l a t e d f r o m a female patient; and assessing the results and comparing them to a normal control wherein an elevated presence of the biomarker compared to a normal control indicates the presence or risk of cancer in the patient from whom the sample is isolated.
There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.
A cartridge for polymerase chain reaction, PCR, comprises a vessel for PCR having an opening and a resealable membrane arranged, in use, to cover the opening of the vessel such that the opening of the vessel is vapour tight.
There is provided a cartridge sealing apparatus (1) comprising a sealing head (10) having a sealing surface (12), the sealing head being adapted in use to hold a sealing member (70) against a surface of a cartridge (100) by application of pressure to the sealing member at the sealing surface across a portion of the sealing member, a bonding layer being present between the sealing member and the cartridge thereby causing the sealing member (70) to seal the cartridge when held against the surface of the cartridge; and a cutting edge (20) arranged around the sealing head (10). The cutting edge is configured to move when the sealing member is held against the surface of the cartridge by the sealing head, from an unextended position, in which the cutting edge is located adjacent the sealing head, to an extended position, in which the cutting edge is adapted to cut the sealing member.
B65B 31/02 - Filling, closing, or filling and closing, containers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
B65B 7/16 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
B65B 7/28 - Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
BELFAST HEALTH AND SOCIAL CARE TRUST (United Kingdom)
Inventor
Kurth, Mary Jo
Lamont, John
Fitzgerald, Peter
Ruddock, Mark
Mcbride, William
Abstract
A method for determining predisposition of a subject to developing renal dysfunction (AKI), and to a kit for use in making such a determination is provided. Suitably at least one marker selected from Midkine (MK) or H-FABP present in a blood or urine sample is used in the method.
BELFAST HEALTH AND SOCIAL CARE TRUST (United Kingdom)
Inventor
Kurth, Mary Jo
Lamont, John
Fitzgerald, Peter
Ruddock, Mark
Mcbride, William
Abstract
A method for determining predisposition of a subject to developing renal dysfunction (AKI), and to a kit for use in making such a determination is provided. Suitably at least one marker selected from Midkine (MK) or H-FABP present in a blood or urine sample is used in the method.
A fluidic card assembly (1) comprises an inlet (20) for introducing a fluid to the fluidic card assembly (1), a turbulent flow portion (30) downstream of the inlet (20), the turbulent flow portion (30) comprising a widening fluid channel (31) whereby a fluid introduced via the inlet (20) channel undergoes turbulence, and a laminar flow portion (40) downstream of the turbulent flow portion (30). The laminar flow portion (40) is configured to allow fluid passing from the turbulent flow portion (30) into the laminar flow portion (40) to establish a laminar flow pattern, and is configured to house a biochip (44) such that a fluid in the laminar flow portion (40) may be in contact with the biochip (44).
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Diagnostic preparations for scientific purposes; chemical reagents for scientific or medical research and for use in the analysis of food products; enzymes for use in scientific and medical research applications; protein arrays for use in scientific and medical research applications; diagnostic preparations for analysis of food products and water for scientific or research use; clinical diagnostic preparations for clinical or medical laboratory use; clinical diagnostic reagents for in vitro use for clinical or medical laboratory use; chemical reagents other than for medical or veterinary purposes, namely, chemical reagents for detection and monitoring of disease states in vitro for laboratory research purposes; diagnostic proteins, namely, protein arrays for scientific and medical research featuring antibodies and antigens used for monitoring of disease states in vitro Diagnostic preparations and substances for medical and veterinary purposes; diagnostic kits in the nature of clinical chemistry and immunology test kits for medical use in the detection and monitoring of disease states in vitro, namely, chemical reagents for medical or veterinary purposes for the detection and monitoring of disease states including cardiac, DOA, stroke, metabolic, cancer, diabetes, fertility, thyroid and DNA arrays; clinical diagnostic preparations, for medical or veterinary use; clinical diagnostic reagents for in vivo use for medical or veterinary purposes; diagnostic scanning agents for in vivo use for medical or veterinary purposes; diagnostic testing materials for medical use in the detection and monitoring of disease states in vitro, namely, chemical reagents for medical or veterinary purposes for the detection and monitoring of disease states including cardiac, DOA, stroke, metabolic, cancer, diabetes, fertility, thyroid and DNA arrays; medical diagnostic proteins, namely, protein arrays for medical diagnostic purposes featuring antibodies and antigens used for medical detection of disease states in vitro; chemical reagents, namely, chemical reagents for detection and monitoring of disease states in vitro Downloadable computer software for use in conjunction with in vitro diagnostic testing apparatus, namely, software for controlling medical and clinical sample processing, sample result reporting and test apparatus system robotics; computer hardware for or relating to the analysis, monitoring, research and/or reporting of clinical data; downloadable computer programs for use in conjunction with in vitro diagnostic testing apparatus for controlling medical and clinical sample processing and sample result reporting; computer systems, namely, computer hardware and downloadable software for use in conjunction with in vitro diagnostic testing apparatus for controlling medical and clinical sample processing and sample result reporting; computer systems for use in conjunction with in vitro diagnostic testing apparatus, namely, downloadable computer software and hardware for controlling medical and clinical sample processing; downloadable computer databases and computer databases recorded on computer media for use in connection with in vitro diagnostic testing apparatus, namely, downloadable electronic data files featuring medical diagnostic sample results; scientific and optical apparatus and instruments, namely, a benchtop analytical system composed of barcode scanner and associated software for reading barcodes, a chemiluminescent detection system in the nature of instruments for measuring chemiluminescence, a temperature controlled incubator for laboratory use, and an electronic reagent and patient sample dispenser, suitable for protein and DNA arrays for or relating to the analysis, monitoring, research and/or reporting of clinical data, for use in vitro diagnostic testing procedures for clinical, veterinary, food and toxicological analysis; clinical analyzers not for medical and veterinary use, namely, acidity analyzers, liquid analyzers, residual gas analyzers for use in vitro diagnostic testing procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs for laboratory use; light detectors for use in vitro diagnostic testing procedures, namely, a chemiluminescence detection system not for medical purposes; parts and fittings for all the aforesaid goods, namely, replacement parts and fittings Medical apparatus and instruments for medical use, namely, for use in vitro diagnostic testing procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins and hormones; diagnostic apparatus and instruments for medical use, namely, for use in vitro diagnostic testing procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs; diagnostic imaging apparatus for medical use, namely, electromechanical diagnostic analyser utilizing a chemiluminescent detection system for use in in vitro diagnostic testing procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs; medical diagnostic testing apparatus and instruments for use in immunoassay procedures, namely, for use in the measurement of antibodies, immunoglobulins, hormones and drugs representing various drug classes; light detectors for use in vitro diagnostic testing procedures, namely, a chemiluminescence detection system for medical purposes; clinical analyzers for medical and veterinary use, namely, acidity analyzers, liquid analyzers, residual gas analyzers for use in vitro diagnostic testing procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Diagnostic preparations for scientific purposes; chemical reagents; enzymes and proteins; diagnostic preparations for analysis of food products and water; clinical diagnostics, other than for medical or veterinary use; diagnostic scanning agents; diagnostic testing materials; clinical diagnostic reagents for in vitro and/or vivo use; parts and fittings for all the aforesaid goods. Pharmaceutical, veterinary and sanitary preparations and substances; antitoxic sera; diagnostic preparations and substances for medical and veterinary purposes; kits for medical purposes; clinical diagnostics, for medical or veterinary use; diagnostic scanning agents for in vivo use; diagnostic testing materials for medical and veterinary use; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes; parts and fittings for all the aforesaid goods. Scientific, nautical, surveying, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; data processing equipment and computers; computer software and computer programs for or relating to the analysis, monitoring, research and/or reporting of clinical data; computer databases relating to the analysis, monitoring, research and/or reporting of clinical data; computer hardware and computer systems for or relating to the analysis, monitoring, research and/or reporting of clinical data; electronic publications relating to the analysis, monitoring, research and/or reporting of clinical data; scientific and optical apparatus and instruments for or relating to the analysis, monitoring, research and/or reporting of clinical data; diagnostic imaging apparatus, other than for medical use; clinical laboratory analytical instruments, other than for medical use, none for use in electrochemical analysis; downloadable electronic publications; parts and fittings for all the aforesaid goods. Medical apparatus and instruments; diagnostic apparatus and instruments for medical use; diagnostic imaging apparatus for medical use; clinical analyzers for medical and veterinary use; diagnostic testing apparatus and instruments for use in immunoassay procedures; detectors and diagnostic testing apparatus and instruments for use in immunoassay procedures; clinical laboratory analytical instruments for medical or veterinary use; clinical laboratory analytical instruments; parts and fittings for all the aforesaid goods.
There is provided achemiluminescencedetector sample enclosure. The enclosure comprises a first interface member forming part of a chemiluminescence detector and having a first sealing element and a second interface member comprising a plurality of sample holders, each sample holder having a second sealing element. The first interface member is engagable with and moveable between sample holder subsets of the plurality of sample holders, engagement with a respective sample holder subset providing engagement of the first interface member witheach sample holder of the respective sample holder subset and relative movement of the first and second interface members providing movement between sample holder subsets; and when the first interface member is engaged with each respective sample holder, the first sealing element and the respective second sealing element are adapted to interact so as to form a light restricting seal between the first interface member and said sample holder.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
The current invention provides novel combinations of biomarkers for use in methods for the diagnosis and differentiation of stroke sub-types. These methods may be enabled by way of substrates comprising immobilised probes to said biomarkers, facilitating their detection in samples taken from patients suspected of having had or currently suffering from a stroke.
The use of glial fibrillary acidic protein (GFAP) as a marker of pernicious stroke is described. The method can also involve subjecting a patient to a brain scan.
There is provided a method of extracting material from a fluid method of extracting material from a fluid, the fluid being held within a fluid chamber. Thee method comprises drawing, with a magnetic field generating system, at least one magnetically susceptible member through the fluid around a closed path between at least three points in the chamber, said at least one member being adapted to bind to material in fluid in the chamber. The at least three points are arranged relative to each other in a shape having at least two dimensions, the magnetic field generating system being configured to move the at least on magnetically susceptible member directly between the at least three points, material in the fluid binding to the at least one magnetically susceptible member when it comes into contact with the at least one member as it moves through the fluid.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Diagnostic preparations for scientific purposes; chemical reagents for scientific or medical research and for use in the analysis of food products; enzymes for use in scientific and medical research applications; protein arrays for use in scientific and medical research applications; diagnostic preparations for analysis of food products and water for scientific or research use; clinical diagnostic preparations for clinical or medical laboratory use; clinical diagnostic reagents for in vitro use for clinical or medical laboratory use; chemical reagents other than for medical or veterinary purpose, namely, chemical reagents for detection and monitoring of disease states in vitro; diagnostic proteins, namely, protein arrays for scientific and medical research featuring antibodies and antigens used for monitoring of disease states in vitro Diagnostic preparations and substances for medical and veterinary purposes; diagnostic kits in the nature of clinical chemistry and immunology test kits for medical use in the detection and monitoring of disease states in vitro, namely, chemical reagents for medical or veterinary purposes for the detection and monitoring of disease states including cardiac, DOA, stroke, metabolic, cancer, diabetes, fertility, thyroid and DNA arrays; clinical diagnostic preparations, for medical or veterinary use; clinical diagnostic reagents for in vivo use for medical or veterinary purposes; diagnostic scanning agents for in vivo use for medical or veterinary purposes; diagnostic testing materials for medical use in the detection and monitoring of disease states in vitro, namely, chemical reagents formedical or veterinary purposes for the detection and monitoring of disease states including cardiac, DOA, stroke, metabolic, cancer, diabetes, fertility, thyroid and DNA arrays; medical diagnostic proteins, namely, protein arrays for medical diagnostic purposes featuring antibodies and antigens used for medical detection of disease states in vitro Computer software for use in conjunction with in vitro diagnostic testing apparatus, namely, software for controlling medical and clinical sample processing, sample result reporting and test apparatus system robotics; computer hardware; computer programs for use in conjunction with in vitro diagnostic testing apparatus for controlling medical and clinical sample processing and sample result reporting; computer systems, namely, computer hardware and software for use in conjunction with in vitro diagnostic testing apparatus for controlling medical and clinical sample processing and sample result reporting; computer systems for use in conjunction with in vitro diagnostic testing apparatus, namely, computer software and hardware for controlling medical and clinical sample processing; downloadable computer databases and computer databases recorded on computer media for use in connection with in vitro diagnostic testing apparatus, namely, downloadable electronic data files featuring medical diagnostic sample results; scientific and optical apparatus and instruments, namely, a benchtop analytical system composed of barcode scanner and associated software for reading barcodes, a chemiluminescent detection system in the nature of instruments for measuring chemiluminescence, a temperature controlled incubator for laboratory use, and an electronic reagent and patient sample dispenser, suitable for protein and DNA arrays for or relating to the analysis, monitoring, research and/or reporting of clinical data, for use in vitro diagnostic testing procedures for clinical, veterinary, food and toxicological analysis; clinical analyzers for medical and veterinary use, namely, acidity analyzers, liquid analyzers, residual gas analyzers for use in vitro diagnostic testing procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs for laboratory use; light detectors for use in vitro diagnostic testing procedures, namely, a chemiluminescence detection system not for medical purposes; parts and fittings for all the aforesaid goods, namely, replacement parts and fittings Medical apparatus and instruments for medical use, namely, for use in vitro diagnostic testing procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins and hormones; diagnostic apparatus and instruments for medical use, namely, for use in vitro diagnostic testing procedures to detect and diagnose drug residues used in immunoassay procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs; diagnostic imaging apparatus for medical use, namely, electromechanical diagnostic analyser utilizing a chemiluminescent detection system for use in in vitro diagnostic testing procedures and for use in measuring blood proteins, antibodies, enzymes, immunoglobulins, hormones and drugs; medical diagnostic testing apparatus and instruments for use in immunoassay procedures, namely, for use in the measurement of antibodies, immunoglobulins, hormones and drugs representing various drug classes; light detectors for use in vitro diagnostic testing procedures, namely, a chemiluminescence detection system for medical purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Diagnostic preparations for scientific purposes; chemical reagents; enzymes and proteins; diagnostic preparations for analysis of food products and water; clinical diagnostics; diagnostic scanning agents; diagnostic testing materials; parts and fittings for all the aforesaid goods. Pharmaceutical preparations and substances; sera and anti-sera; diagnostic preparations and substances for medical and veterinary purposes; kits for medical purposes; clinical diagnostics, for medical or veterinary use; clinical laboratory analytical instruments for medical or veterinary use; clinical diagnostic reagents for in vitro and/or vivo use; diagnostic scanning agents for in vivo use; diagnostic testing materials for medical use; clinical laboratory analytical instruments; parts and fittings for all the aforesaid goods. Computer software and computer programs for or relating to the analysis, monitoring, research and/or reporting of clinical data; computer databases relating to the analysis, monitoring, research and/or reporting of clinical data; computer hardware and computer systems for or relating to the analysis, monitoring, research and/or reporting of clinical data; electronic publications relating to the analysis, monitoring, research and/or reporting of clinical data; scientific and optical apparatus and instruments for or relating to the analysis, monitoring, research and/or reporting of clinical data; diagnostic imaging apparatus, other than for medical use; clinical laboratory analytical instruments, other than for medical use, none for use in electrochemical analysis; parts and fittings for all the aforesaid goods. Medical apparatus and instruments; diagnostic apparatus and instruments for medical use; diagnostic imaging apparatus for medical use; clinical analyzers for medical and veterinary use; diagnostic testing apparatus and instruments for use in immunoassay procedures; detectors and diagnostic testing apparatus and instruments for use in immunoassay procedures; parts and fittings for all the aforesaid goods.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals used in industry, science, photography,
agriculture, horticulture and forestry; chemical reagents;
enzymes and proteins; diagnostic preparations for scientific
purposes; diagnostic preparations for analysis of food
products and water, and all the aforesaid for sale in kit
form; chemical diagnostic reagents for industrial use;
chemical diagnostic scanning agents for industrial use;
diagnostic testing materials, other than for medical use;
chemical reagents for use in diagnostic tests. Pharmaceutical, veterinary and sanitary preparations and
substances; sera and antisera; diagnostic preparations;
diagnostic preparations for sale in kit form; clinical
diagnostics for medical and veterinary use; clinical
diagnostic reagents for in vitro and/or vivo use; diagnostic
scanning agents for medical purposes; clinical diagnostics,
for medical and veterinary use; diagnostic testing materials
for medical and veterinary use; clinical medical reagents;
reagents for use in diagnostic tests for medical and
veterinary purposes; reagents for use with analyzers for
medical and veterinary purposes. Scientific, nautical, surveying, optical, weighing,
measuring, signalling, checking (supervision), life-saving
and teaching apparatus and instruments; data processing
equipment and computers; computer software and computer
programs for or relating to the analysis, monitoring,
research and/or reporting of medical and clinical data;
computer databases relating to the analysis, monitoring,
research and/or reporting of medical and clinical data;
computer hardware and computer systems for or relating to
the analysis, monitoring, research and/or reporting of
medical and clinical data; electronic publications relating
to the analysis, monitoring, research and/or reporting of
medical and clinical data; scientific and optical apparatus
and instruments for or relating to the analysis, monitoring,
research and/or reporting of medical and clinical data;
diagnostic imaging apparatus, other than for medical use;
diagnostic testing apparatus and instruments for use in
immunoassay procedures [other than medical]; downloadable
electronic publications; biochips; incubators for laboratory
use; detectors; diagnostic apparatus and instruments, not
for medical purposes; diagnostic testing apparatus and
instruments for use in immunoassay procedures, not for
medical purposes; diagnostic imaging apparatus other than
for medical use; clinical laboratory analytical instruments
other than for medical use. Medical apparatus and instruments; diagnostic apparatus and
instruments for medical use; diagnostic imaging apparatus
for medical use; clinical chemistry analyzers for medical
and veterinary use; diagnostic testing apparatus and
instruments for use in immunoassay procedures [medical];
analysers for medical use; clinical laboratory analytical
instruments for medical and veterinary use. Scientific and technological services and research and
design relating thereto; medical research services; clinical
research services; biological research; analysis, management
and/or reporting of clinical data; quality assessment
services for clinical laboratories; chemical research;
chemical laboratory services; chemical analysis; laboratory
services for analytical testing; medical laboratory
services; biochemistry research and advisory services;
conducting clinical trials; computer aided diagnostic
testing services; development of test equipment for medical
apparatus; advice, information and consultancy services
relating to all the aforesaid services.
The present invention relates to a multiplexing system comprising a support substrate having immobilised thereto one or more of the following proteins, fragments thereof or a binding molecule, wherein the binding molecule binds specifically to one of the following proteins: E-FABP, B-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP. Another aspect is directed to a method for characterising the pattern of FABP antigens existing within a biological sample to reveal information useful in the diagnosis or disease or injury.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
chemicals used in industry and science; chemicals for use in agriculture, horticulture and forestry except fungicides, herbicides, insecticides and parasiticides; chemical reagents for non-medical purposes; enzymes and proteins for scientific and research purposes; diagnostic preparations for scientific purposes; kits comprised primarily of diagnostic preparations for analysis of food products and water for scientific and research use; chemical diagnostic reagents for industrial use; chemical diagnostic scanning agents for industrial use; diagnostic testing materials, namely, diagnostic preparations other than for medical use; chemical reagents for use in diagnostic tests other than for medical or veterinary use Pharmaceutical, veterinary preparations and substances for the detection of drug residues, namely, antibiotic, non-steroidal anti-inflammatory and anti-parasitic residues; sanitary preparations for medical use; antitoxic sera and pharmaceutical preparations in the nature of antisera for the detection of drug Residues, namely, antibiotic, non-steroidal anti-inflammatory and anti-parasitic residues; diagnostic preparations for medical purposes; kits comprised of diagnostic preparations for medical purposes; clinical diagnostic preparations for medial and veterinary use; diagnostic testing preparations for medical and veterinary use; clinical diagnostic reagents for in vitro and/or vivo use; diagnostic scanning agents for medical purposes; clinical diagnostics preparation for medical and veterinary use; diagnostic testing preparations for medical and veterinary use; clinical medical reagents; clinical medical reagents; reagents for use in diagnostic tests for medical and veterinary purposes; reagents for use with analyzers for medical and veterinary purposes Scientific, nautical, surveying, optical, weighing, measuring, signaling, checking supervision, life-rescue and teaching apparatus and instruments, namely, cuvettes wash station, chemical reagent carousel in the nature of automated reagent sample processing apparatus, chemical reagent sample carousel, chemical reaction carousel in the nature of automated reagent sample processing apparatus, cuvettes and pipettes; data processing equipment and computers; computer software and computer programs for analysis, monitoring, research and reporting of medical and clinical data; computer software programs for accessing data from computer databases for use in analysis, monitoring, research and reporting of medical and clinical data; computer hardware and computer systems composed of computer hardware and computer software all for the analysis, monitoring, research and reporting of medical and clinical data; electronic publications, namely, magazines, newsletters, journals, periodical publications, manuals, featuring information about the analysis, monitoring, research and/or reporting of medical and clinical data; scientific and optical apparatus and instruments for the analysis, monitoring, research and reporting of medical and clinical data, namely, cuvettes wash station, chemical reagent carousel in the nature of automated reagent sample processing apparatus, chemical reagent sample carousel, chemical reaction carousel in the nature of automated reagent sample processing apparatus, cuvettes and pipettes; diagnostic testing apparatus and instruments for detection of restricted drugs for use in immunoassay procedures, not for medical purposes; downloadable electronic publications in the nature of brochures, product manuals, safety data sheets, white papers and posters in the field of clinical chemistry testing, veterinary, toxicology, protein and genetic research; biochips for research or scientific purposes; incubators for laboratory use; detectors, namely, a charge coupled device camera for measuring the generation of light from a chemiluminescence reaction; diagnostic apparatus and instruments for detection of restricted drugs, not for medical purposes; diagnostic imaging apparatus used for clinical chemistry testing, veterinary, toxicology, protein and genetic research, other than for medical use;clinical laboratory analytical instruments used for testing and diagnostic services for others in the fields of science and research related thereto, other than for medical use, namely, cuvettes wash station, chemical reagent carousel in the nature of automated reagent sample processing apparatus, chemical reagent sample carousel, chemical reaction carousel in the nature of automated reagent sample processing apparatus, cuvettes and pipettes diagnostic imaging apparatus for medical use, namely a charge coupled device camera for measuring the generation of light from a chemiluminescence reaction; clinical chemistry analyzers for use in analyzing biological samples for medical and veterinary use; diagnostic testing apparatus and instruments for detection of antibiotics / non-steroidal, anti-inflamatory and anti-parasitic drug residues used in immunoassay procedures for use in immunoassay procedures; clinical laboratory analytical instruments for medical and veterinary use for the detection of antibiotics / non-steroidal, anti-inflammatory and anti-parasitic drug residues Scientific and technological services and research and design in the nature of scientific research, analysis and design in the field of food testing, veterinary, toxicology, and food research provided for clinical laboratories, university and education institutes, research laboratories, veterinary laboratories and food and wine laboratories; medical research services; clinical research services, namely, for research of immunoassay technology, biotechnology, veterinary, toxicology, protein and food and wine testing; biological research; analysis, management and reporting of clinical data namely, immunoassay technology, veterinary, toxicology, protein, food and wine and research data; consulting services in the field of quality assessment services for clinical laboratories; chemical research; chemical laboratory services; chemical analysis; laboratory services for analytical testing; medical laboratory services; conducting clinical trials for others; computer aided diagnostic testing services, namely, providing reagent sample testing and diagnostic services for others in the fields of science and research related thereto; development of test equipment for medical apparatuses for others; advice, information and consultancy services relating to all the aforesaid services
