Abstract

Methods of treating CD47+ cancer in a subject involving administering an immunotoxin to the subject. The immunotoxin may be a bivalent anti-human CD47 immunotoxin that includes a portion of a diphtheria toxin. The disclosed immunotoxin treats CD47+ cancers via targeted therapy.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/46 - Hybrid immunoglobulins
• C12N 1/15 - Fungi ; Culture media therefor modified by introduction of foreign genetic material
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

Abstract

Embodiments disclosed herein concern a device for implantation of a cellular transplant into a target region of a subject. The device includes: a handpiece; a shaft anchored with the handpiece and extending distally therefrom; and a tubular sheath. The shaft includes a proximal end, a distal end opposite the proximal end, a curved portion, and forceps at the distal end thereof. The forceps include a pair of distal tips configured to releasably grasp the cellular transplant. The tubular sheath is movably coupled to and extending distally from the handpiece. The tubular sheath includes a distal opening and a lumen configured to slidably receive the shaft and the forceps therein. In a non-deployed state, the distal tips of the forceps are positioned within the lumen of the tubular sheath, and, in a deployed state, the distal tips of the forceps are positioned partially outside the distal opening of the tubular sheath.

IPC Classes  ?

• A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/30 - Surgical pincettes

Abstract

Bioderived pressure-sensitive adhesives. The present invention solves ongoing needs for further biofriendly adhesives. The role of mobile cross-links on the properties of a bio-friendly adhesive made using composites of cyclodextrin-based macromolecules and poly(lipoic acid) is demonstrated. Cyclodextrin-based hosts and polyrotaxanes with pendant groups of lipoic acid (a commonly ingested antioxidant) are modified to incorporate them as cross-links in poly(lipoic acid) networks obtained by simple heating in open air. By systematically varying the adhesive formulations while probing their mechanical and adhesive properties, trends in structure-property relationships that enable one to tune network properties and access bio-friendly, high-tack pressure-sensitive adhesives are shown. This invention provides bio-derived adhesive materials that are biofriendly and exhibit adhesion underwater. Multiple applications are possible including a pressure sensitive adhesive, a load bearing adhesive, an underwater adhesive, and adhesives for biomedical applications.

IPC Classes  ?

• C09J 7/38 - Pressure-sensitive adhesives [PSA]
• C09J 105/16 - Cyclodextrin; Derivatives thereof

Abstract

Embodiments of the instant disclosure relate to novel constructs including constructs having antimicrobial applications, hemostatic applications, wound healing applications, analgesic activity, or a combination thereof and compositions, and methods for making and using the same. In certain embodiments, the present disclosure provides methods of providing an antimicrobial agent to a subject, medical device, or surface, the method including applying to the subject, medical device, or surface a composition of at least one construct of disclosed herein.

Abstract

A nanosensor for detecting a force includes a metal layer, a flexible-material layer, and a photoluminescent material. The flexible-material layer is deposited on a top surface of the metal layer. The photoluminescent material is attached to, or at least partially embedded in the flexible-material layer and configured to emit first photoluminescence when optically excited at an excitation wavelength. The first photoluminescence has a first wavelength different from the excitation wavelength. The first intensity of the first photoluminescence changes with a distance between the photoluminescent material and the metal layer, where the distance changes in response to the force acting on the flexible-material layer.

IPC Classes  ?

• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

Abstract

A system and method for end-to-side anastomosis to an anatomical passageway is disclosed. The system and method are particularly useful in coupling an LVAD pump to an aorta. The system and method include using a tubular graft member having a skirt flange that engages the side of the aorta, a seating assembly and a flanged stent for securing the tubular graft to the side of the anatomical passageway. An assembly for creating an opening in the side of the anatomical passageway and an assembly for delivering the tubular graft is also disclosed.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/064 - Surgical staples
• A61B 17/115 - Staplers
• A61F 2/07 - Stent-grafts
• A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
• A61M 60/857 - Implantable blood tubes
• A61M 60/859 - Connections therefor
• A61M 60/861 - Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient’s body

Abstract

According to some aspects of the present disclosure, an atomic clock and methods of forming and/or using an atomic clock are disclosed. In one embodiment, an atomic clock includes: a light source configured to illuminate a resonance vapor cell; a narrowband optical filter disposed between the light source and the resonance vapor cell and arranged such that light emitted from the light source passes through the narrowband optical filter and illuminates the resonance vapor cell. The resonance vapor cell is configured to emit a signal corresponding to a hyperfine transition frequency in response to illumination from the light source, and a filter cell is disposed between the light source and the resonance vapor cell and configured to generate optical pumping. An optical detector is configured to detect the emitted signal corresponding to the hyperfine transition frequency.

IPC Classes  ?

• G04F 5/14 - Apparatus for producing preselected time intervals for use as timing standards using atomic clocks
• G02B 5/20 - Filters
• G04F 5/04 - Apparatus for producing preselected time intervals for use as timing standards using oscillators with electromechanical resonators

Abstract

Devices including a volume containing a ferroelectric nematic liquid crystalline material, a dielectric layer overlying a portion of the volume, and a charge-bearing substrate or layer are disclosed. Methods of forming and using such devices are also disclosed.

IPC Classes  ?

• G02F 1/141 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering based on orientation effects in which the liquid crystal remains transparent using ferroelectric liquid crystals
• G02F 1/1337 - Surface-induced orientation of the liquid crystal molecules, e.g. by alignment layers

Abstract

Compositions and methods for diagnosing and treating multiple sclerosis (MS) and other health conditions involve collecting serum samples from a subject and exposing the serum samples to a protein capture composition, collecting the unbound eluent or flow-through, and measuring the levels of at least one immunoglobulin therein. Methods for differentiating between different types of MS also involve exposing serum samples to a protein capture composition and detecting immunoglobulin levels in the flow-through. Based on the detected immunoglobulin levels, an MS subtype is diagnosed in a subject and a treatment regimen can be adjusted or ceased according to the diagnosis.

IPC Classes  ?

• G01N 33/564 - Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease

Abstract

Embodiments of the instant disclosure relate to compositions and methods for enhancing fertility in humans and non-human animals. In certain embodiments, the instant disclosure relates to making and using conditioned extracellular vesicles (EVs) from epididymal epithelial cells (EECs). In other embodiments, the conditioned EVs disclosed herein can be created for use in inducing sperm motility and improving fertility in humans and non-human animals. In some embodiments, conditioned EVs can be used to induce sperm motility by at least five percent (5%) compared to controls not exposed to the conditioned EVs created herein. Certain embodiments related to compositions containing conditioned EVs, sperm and a medium.

IPC Classes  ?

• A61K 35/52 - Sperm; Prostate; Seminal fluid; Leydig cells of testes
• A01K 67/02 - Breeding vertebrates

Abstract

A liquid metal (LM) sensor is provided herein. In certain embodiments, the LM sensor includes a wire. In certain embodiments, the wire includes a LM composite material. In certain embodiments, the LM composite material includes a LM material and a nonconductive material.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

Increased PARN as an indicator of a cancer involving loss or reduction in p53 function. PARN is also provided as a therapeutic target for treating a cancer involving loss or reduction in p53 function. Methods of treating a subject having a cancer involving loss or reduction in p53 function based on the level of PARN in a test sample obtained from the subject and administering an effective amount of a PARN inhibitor, alone or in conjunction with another chemotherapeutic agent, to the subject to treat the cancer.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61P 35/00 - Antineoplastic agents
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Systems and methods for human-robot communication. More particularly, some embodiments use augmented reality to facilitate communication of robot intention and teleoperation in human-robot cooperative environments. Various embodiments of the present technology provide a middleware that integrates augmented reality (AR) with novel teleoperation interfaces to increase operation effectiveness, support the user in conducting concurrent work, and decrease stress. Various embodiments provide predictive graphical interfaces such that a teleoperator controls a virtual robot surrogate, rather than directly operating the robot itself, providing the user with foresight regarding where the physical robot will end up and how it will get there. In accordance with various embodiments a user may select between two AR interfaces using such a surrogate: one focused on real-time control and one inspired by waypoint delegation.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B25J 13/06 - Control stands, e.g. consoles, switchboards
• G06F 3/14 - Digital output to display device
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06V 20/10 - Terrestrial scenes

Abstract

Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.

IPC Classes  ?

• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07H 19/073 - Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Abstract

Low viscosity urethane (meth)acrylate monomers and polymerizable resin compositions are provided to facilitate production of tough polymers with well-controlled modulus and strength.

IPC Classes  ?

• C08F 220/34 - Esters containing nitrogen
• A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
• C08F 222/10 - Esters
• C08J 5/18 - Manufacture of films or sheets

Abstract

Disclosed are ultrathin, fully printed capacitive devices that can be mounted onto living plant surfaces with a simple transfer process. The capacitive devices are based on conductive ink trace and can detect relative humidity (RH) directly at the plant tissue-environment interface. By completely encapsulating the device's electronic features between thin swellable layers (e.g., ethyl cellulose), a significant increase in sensor capacitance, SNR and sensitivity is revealed. The capacitive devices may exhibit baseline capacitance values in the nF range, high sensitivity (up to 1 nF/%RH) over a wide range of RH values and stability over several days or months.

IPC Classes  ?

• G01R 31/312 - Contactless testing by capacitive methods
• H01G 4/30 - Stacked capacitors

Abstract

Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.

IPC Classes  ?

• A61L 24/04 - Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
• A61L 24/00 - Surgical adhesives or cements; Adhesives for colostomy devices
• C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
• C08J 3/075 - Macromolecular gels

Abstract

Various implementations include a device for transferring free-flowing material. The device includes a gantry, an arm, a gripper, and a tool head. The arm has a longitudinal axis, a first arm portion, a second arm portion spaced apart from the first arm portion along the arm longitudinal axis, and a middle arm portion disposed between the first arm portion and the second arm portion. The middle arm portion is rotatably coupled to the gantry. Various implementations include a reactor system. The reactor system includes a reactor core and an outer support structure. The reactor core is configured to receive one or more containers for containing a chemical reaction.

IPC Classes  ?

• B25J 15/10 - Gripping heads having finger members with three or more finger members
• B25J 15/04 - Gripping heads with provision for the remote detachment or exchange of the head or parts thereof

Abstract

Methods of forming nucleating formation of material and material formed using the methods are disclosed. Desired features, such as size and morphology of nucleating agents, can be controlled by controlling growth parameters of biomineralizing microorganisms and/or biomineralizing microorganisms to obtain desired nucleating formation properties.

IPC Classes  ?

• C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide

Abstract

Use of PRDX6 is a predictive survival marker for several tumor types and drug targets, as well as using PRDX6 inhibitors to sensitize cancer cells to HDACi, PD1 and PD-L1 inhibitors.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/18 - Sulfonamides
• A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
• A61K 31/4406 - Non-condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
• A61K 38/15 - Depsipeptides; Derivatives thereof
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• C07C 259/06 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
• C07K 11/02 - Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G16B 25/10 - Gene or protein expression profiling; Expression-ratio estimation or normalisation

Abstract

In some embodiment, the present invention is directed to a device for obtaining samples from a subject. In other embodiments, methods and devices of the present invention allow the evaluation of conditions of the gastrointestinal tract of a subject. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.

IPC Classes  ?

• A61B 1/273 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
• C12Q 1/527 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

Haze tunable assemblies and methods of forming and using the assemblies are disclosed. Exemplary assemblies include two or more substrates and a composite liquid crystal material interposed between at least two of the substrates. Exemplary assemblies exhibit large variation in haze upon application of a relatively low voltage and can retain desired transmission of visible light transmission.

IPC Classes  ?

• G02F 1/139 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on liquid crystals, e.g. single liquid crystal display cells characterised by the electro-optical or magneto-optical effect, e.g. field-induced phase transition, orientation effect, guest-host interaction or dynamic scattering based on orientation effects in which the liquid crystal remains transparent
• G02F 1/1339 - Gaskets; Spacers; Sealing of cells

Abstract

Amine substituted morpholino oligonucleotides, other than the classical N,N-dimethylamino PMO analogue, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. Morpholino oligonucleotides having thiophosphoramidate, phosphoramidate, and alkyl phosphoramidate linkers. Chimeras containing unmodified DNA/RNA and other analogs of DNA/RNA can be prepared. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous applications.

IPC Classes  ?

• C07F 9/6558 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
• C07F 9/44 - Amides thereof
• C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

A method for forming an oxygen reduction reaction (ORR) catalyst (200, 900) may include providing a carbon (210, 910) supported platinum nanoparticle (220, 920) substrate (Pt/C) (110) and applying a tungsten nitride (WN) film (940) onto the surface of the Pt/C substrate (210, 220, 910, 920) using atomic layer deposition (ALD) (120). The Pt/C substrate (210, 220, 910, 920) with the WN film (940) may then be oxidized at a low temperature (130) and annealed at a high temperature in order to reduce WN to metallic tungsten (W) (140). The metallic W forms a blocking layer (230, 930) over coarse Pt nanoparticles (220, 920) and improves the activity and the durability of the Pt/C catalyst (900, 200) when used in fuel cells or related applications.

IPC Classes  ?

• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• C23C 16/06 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the deposition of metallic material
• C23C 16/34 - Nitrides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• C23C 16/56 - After-treatment
• H01M 4/92 - Metals of platinum group
• H01M 8/10 - Fuel cells with solid electrolytes

Abstract

The disclosure describes T cells that express chimeric antigen receptors (CARs), as well as pharmaceutical compositions comprising T cells and methods of making and using such T cells. Particularly, this disclosure describes T cells expressing a first CAR that binds to a first antigen and a second CAR comprising a CD3ε intracellular signaling domain that binds to a second antigen, and methods of use in treating cancers, such as solid tumors and hematological malignancies.

IPC Classes  ?

• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/02 - Antineoplastic agents specific for leukemia
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells

Abstract

The invention described the therapeutic treatment of mitochondrial disease caused by mtDNA mutants with vitamin MK-4 which restores cellular ATP and cytosolic Ca2+ levels, improves synaptic development, and suppresses sensory and behavioral defects and embryonic death.

Abstract

A system for fractionating multiple fractions of particles from a sample includes a fractionation unit including a flow channel divided into two or more compartments by one or more porous membranes of known pore size and a flow module system in fluid connection with the fractionation unit. The flow module system further includes a sample container for the sample, a backwash container for a backwash fluid, and two or more collection containers for collection of fractionated portions of the sample, each of the collection containers being in fluid connection with a different one of the compartments. The system further includes a control system in operative connection with the flow module system to control flow.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

A feeding tube configured to allow intact pills to pass through an internal lumen of the feeding tube. Some embodiments of the feeding tube include a main body having a lumen extending between a proximal end and a distal end of the main body. The proximal end includes an inlet aperture leading to the lumen and the distal end includes an outlet aperture fluidically coupled to the lumen. The main body includes a thin-walled transcutaneous section configured to temporarily receive a tubular structural support member that can operate as a traditional feeding tube. The tubular structural support member can be removed to allow a pill delivery device to deliver an intact pill through the lumen and out of the outlet aperture.

IPC Classes  ?

• A61J 15/00 - Feeding-tubes for therapeutic purposes

Abstract

A multi-layer current collector for an anodeless lithium-metal cells is described. The multi-layer current collector includes a current collector layer, a seed layer disposed on the current collector layer, and a protective shield layer disposed on the current collector layer. When incorporated into a Li-metal cell along with an electrolyte, charging of the cell leads to Li ion transferring through the shield layer, saturating the seed layer and ultimately forming a new Li metal layer between the shield layer and the lithiated seed layer. Discharging the cell reverses this process and results in disappearance of the Li metal layer and lithium passes back through the shield layer and into the electrolyte. The lithium in the seed layer also passes back into the electrolyte such that the current collector reverts to its initial structure prior to charging.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/04 - Processes of manufacture in general
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/052 - Li-accumulators

Abstract

A computer-implemented method and system can generate a dynamic anatomical representation of an individual. A system can obtain demographic data of the individual and a series of indexed three-dimensional (3D) medical imaging datasets corresponding to distinct phases of a respiratory cycle. A surface mesh model can be created to represent an external body contour. A skeletal mesh model can be derived using the surface mesh model, demographic data, and a comparative anatomical data library. Real-time image data depicting external surface features can be captured, and a dynamic anatomical representation can be generated by registering these images with the skeletal mesh model. The representation can adapt to reflect changes in a pose of the individual.

IPC Classes  ?

• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 6/03 - Computerised tomographs
• A61B 6/50 - specially adapted for specific body parts; specially adapted for specific clinical applications
• A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
• G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts

Abstract

A multi-material volumetric design compiler parses a script to generate a tree structure representing an object having multiple materials. The tree structure includes one or more leaf nodes, one or more composite nodes, and one or more multi-material nodes. Each leaf node represents a geometric primitive. Each composite node defines (i) a transformation of one sub-object connected to the composite node or (ii) a combination of two sub-objects connected to the composite node. Each multi-material node defines how each of at least two of the multiple materials is distributed over a volume of a sub-object connected to the multi-material node. The tree structure is processed to generate a multi-material volumetric representation of the object that may be outputted to a multi-material additive manufacturing device (e.g., a three-dimensional printer).

IPC Classes  ?

• G06T 15/08 - Volume rendering
• G06T 17/10 - Volume description, e.g. cylinders, cubes or using CSG [Constructive Solid Geometry]
• G06F 30/20 - Design optimisation, verification or simulation
• B29C 64/00 - Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
• G06F 30/00 - Computer-aided design [CAD]

Abstract

A method of screening a test compound, e.g., a fibrosis or IPF inhibitor, for induction of an unjammed-to-jammed transition (UJT) in fibrotic primary human bronchial epithelial cells (HBECs) isolated from a subject with a fibrotic lung disease includes culturing the fibrotic primary HBECs at an air-liquid interface for a time sufficient to provide a differentiated pseudostratified epithelium contacting the cultured cells with the test compound; and monitoring the motility of the cultured cells to identify the cultured cells as moving or stationary; wherein stationary cultured cells indicate that the test compound induces the UJT. Also included are methods of identifying lung fibrosis biomarkers.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The present disclosure relates to methods of using electrochemically-generated superoxide to break down polyesters into their monomers. These methods can be used, for example, to recycle polyester polymers.

IPC Classes  ?

• C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation
• C07C 67/02 - Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification
• C08J 11/04 - Recovery or working-up of waste materials of polymers
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring

Abstract

An ophthalmic implant including an intraocular lens (IOL) and at least one drug delivery device. The IOL including an anterior side, a posterior side, a lens, and at least one haptic extending outwardly from the lens and including a first haptic extending from the lens at a first optic-haptic junction. The at least one drug delivery device including a first drug delivery device including a pad and a fixation portion extending from the pad. The pad including at least one therapeutic agent contained therein, an anterior surface, a posterior surface, and a sidewall extending around the pad and between the anterior surface and the posterior surface. The drug delivery device configured for attachment to the IOL via the fixation portion. In an assembled state of the implant, the first drug delivery device is attached to the IOL and the pad overlays the first optic-haptic junction.

IPC Classes  ?

• A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
• A61F 2/16 - Intraocular lenses

Abstract

A method for preventing an error from being triggered includes receiving a sanitizer report of a program as an input, analyzing the sanitizer report to find information about an error in a sanitized kernel image, mapping the information about the error to a native kernel image, constructing a triggering condition based on the information in a native kernel image, and in a case where the triggering condition is met, sending a command to an operating system to kill the program in the native kernel image.

IPC Classes  ?

• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance

Abstract

A method for dynamic repetition-rate control of a single-cavity dual-comb laser (SCDCL) includes controlling the SCDCL such that a repetition-rate difference between first and second pulse trains generated by the SCDCL has a positive value, recording an interferogram with the first and second pulse trains while the repetition-rate difference has the positive value, and controlling, after said recording, the SCDCL such that the repetition-rate difference between the first and second pulse trains has a negative value. The first and second pulse trains accrue a first temporal offset while the repetition-rate difference has the positive value. The first and second pulse trains accrue a second temporal offset while the repetition-rate difference has the negative value. The first temporal offset and the second temporal offset have the same magnitude and opposite signs.

IPC Classes  ?

• G01J 3/427 - Dual wavelength spectrometry
• G01J 3/45 - Interferometric spectrometry
• H01S 3/1109 - Active mode locking
• H01S 3/1112 - Passive mode locking

Abstract

Embodiments of the instant disclosure relate to compositions and methods for making and using engineered T cells or other immune-related cells. In certain embodiments, engineered T cells disclosed herein include up-regulated or increased expression of one or more Formin family proteins in the engineered T cells. In some embodiments, the engineered T cells include at least one of CD8+ cells, CD4+ T cells, chimeric antigen receptor (CAR)-T cell or other T cell of use to treat a health condition. In certain embodiments, engineered T cells disclosed herein can be used to treat cancer, autoimmunity, or other health condition in a subject.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes

Abstract

A vacuum-gap optical cavity includes a spacer having a first spacer surface and a second spacer surface, a first mirror having a first reflective coating formed on a first substrate, and a second mirror having a second reflective coating formed on a second substrate. The spacer forms a cavity region that extends between a first aperture at the first spacer surface and a second aperture at the second spacer surface. The first mirror is bonded to the first spacer surface such that the first reflective coating overlaps the first aperture and such that the first mirror completely covers the first aperture. The second mirror is bonded to the second spacer surface such that the second reflective coating overlaps the second aperture and such that the second mirror completely covers the second aperture. The cavity region is maintained under vacuum without active pumping.

IPC Classes  ?

• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 5/10 - Construction or shape of the optical resonator
• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• H01S 3/13 - Stabilisation of laser output parameters, e.g. frequency or amplitude
• H01S 5/06 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium
• G02B 5/28 - Interference filters

Abstract

Disclosed herein is a process for separating a hydrocarbon feed gas mixture comprising constituents including ethylene to produce a separated ethylene product. The disclosed process employs a solid-state ethylene sorbent and temperature and/or pressure swing adsorption and membrane separation and demonstrates a methodology to reduce the net heat of reaction during the adsorption of ethylene onto an adsorbent.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/02 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01D 53/047 - Pressure swing adsorption
• C07F 1/08 - Copper compounds

Abstract

Material comprising a ferroelectric nematic phase, the material are disclosed. The material can include a mixture comprising first molecules and second molecules. At least one of a fluid of the first molecules and a fluid of the second molecules exhibits a ferroelectric nematic phase. The first molecules and second molecules are miscible. The first molecules can induce a polar orientational order of said second molecules.

IPC Classes  ?

• C09K 19/02 - Liquid crystal materials characterised by optical, electrical or physical properties of the components, in general
• C09K 19/06 - Non-steroidal liquid crystal compounds
• C09K 19/20 - Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings linked by a chain containing carbon and oxygen atoms as chain links, e.g. esters
• C09K 19/46 - Mixtures of liquid crystal compounds covered by two or more of the preceding groups containing esters

Abstract

A system for fine-scale, in-situ measurements of turbulence in the atmosphere is described. The system may be a balloon-borne instrument, performing measurements during slow descents from stratospheric altitudes, and may include at least some of onboard data compression, telemetry of data to a ground station, self-calibration, and data processing to extract turbulence parameters.

IPC Classes  ?

• G01W 1/06 - Instruments for indicating weather conditions by measuring two or more variables, e.g. humidity, pressure, temperature, cloud cover or wind speed giving a combined indication of weather conditions
• G01W 1/00 - Meteorology
• G01W 1/08 - Adaptations of balloons, missiles, or aircraft for meteorological purposes; Radiosondes

Abstract

Modulation of switching intervals over a line cycle in an inverter system is provided. In one embodiment, an inverter circuit includes input and output ports, first and second switches. The inverter circuit provides a substantially sinusoidal output voltage or current. The first and second switches operate with a switching frequency and deadtimes. A first controller operates in conjunction with a first control loop to provide control signals for the first switch and second switch. A second controller operates in conjunction with a second control loop and adapted to provide a plurality of distinct timing parameters for a plurality of individual time periods within the line cycle of the substantially sinusoidal output voltage or current. The first controller is adapted to provide the control signals for the first switch and the second switch based in part on the timing parameters provided by the second controller.

IPC Classes  ?

• H02M 7/5387 - Conversion of dc power input into ac power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
• H02M 1/00 - APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF - Details of apparatus for conversion
• H02M 1/38 - Means for preventing simultaneous conduction of switches

Abstract

A medical device is provided. The medical device includes a selectively strainable surface and a plurality of protrusions extending from the selectively strainable surface. One or more protrusions of the plurality of protrusions are configured to undergo a transformation including at least one of deformation and migration in response to a change in strain of the selectively strainable surface.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
• A61M 25/02 - Holding devices, e.g. on the body

Abstract

A qubit array reparation system includes a reservoir of ultra-cold particle, a detector that determines whether or not qubit sites of a qubit array include respective qubit particles, and a transport system for transporting an ultra-cold particle to a first qubit array site that has been determined by the probe system to not include a qubit particle so that the ultra-cold particle can serve as a qubit particle for the first qubit array site. A qubit array reparation process includes maintaining a reservoir of ultra-cold particles, determining whether or not qubit-array sites contain respective qubit particles, each qubit particle having a respective superposition state, and, in response to a determination that a first qubit site does not contain a respective qubit particle, transporting an ultracold particle to the first qubit site to serve as a qubit particle contained by the first qubit site.

IPC Classes  ?

• H01L 29/66 - Types of semiconductor device
• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
• H01L 29/15 - Structures with periodic or quasi periodic potential variation, e.g. multiple quantum wells, superlattices
• H01L 29/775 - Field-effect transistors with one-dimensional charge carrier gas channel, e.g. quantum wire FET
• H10N 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

An exemplary system and method for a single-conductor capacitive touch or contact sensor or human-machine-interface that can be integrated into a 2D or 3D-formed body. The exemplary system and method can be employed in the design and/or construction/fabrication of a tactile sensor-device having minimal instrumentation and wiring to provide interactive functionality. In some embodiments, the exemplary system and method can provide n number of sensing nodes on a device through the use of a single channel input of a controller without multiplexing by evaluating and encoding each sensing node to an RC delay uniquely established for the sensing node.

IPC Classes  ?

• G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
• B33Y 80/00 - Products made by additive manufacturing
• G06F 3/044 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means by capacitive means

Abstract

This invention relates to methods and compositions for overcoming the dose-dependent down regulation of interleukin 10 (IL-10) by expressing, in addition to an interleukin 10 (IL-10) peptide, an IL-10 receptor type 1 (IL-10R1) peptide. The methods have use in treating a variety of diseases and symptoms, including but not limited to neuropathic or chronic pain; symptoms and physiological damage associated with multiple sclerosis, spinal cord injury, ALS, neuroinflammation, arthritis and other diseases of the joint; and autoimmune diseases.

IPC Classes  ?

• C07K 14/715 - Receptors; Cell surface antigens; Cell surface determinants for interferons
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 35/17 - Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
• A61K 35/30 - Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 38/20 - Interleukins
• A61P 25/00 - Drugs for disorders of the nervous system
• C07K 14/54 - Interleukins (IL)
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

A method for estimating portal blood flow and hepatic function in a subject is provided. In one example, the STAT test is an in vitro simplified, convenient test intended for screening purposes that can reasonably estimate the portal blood flow from a single blood sample taken 60 minutes after orally administered deuterated-cholate. The test can be administered to a patient having, or suspected of having, Chronic Hepatitis C, Primary Sclerosing Cholangitis (PSC), Non-Alcoholic Fatty Liver Disease (NAFLD), or any chronic liver disease.

IPC Classes  ?

• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol

Abstract

Systems and methods to eliminate or reduce the foreign body response (FBR) that occurs when a medical device or other material is implanted into a patient. The FBR causes a chronic inflammatory response that leads to the encapsulation of a medical device by a fibrous capsule. Macrophages have been discovered to become persistent as a result of the implanted biomaterial which occurs by an up-regulation in TLR2 and TLR4. This persistence of macrophages appears to be the primary driver of the FBR. Re-sensitizing macrophages to apoptosis using a small molecule inhibitor of TLR2 and TLR4 will abrogate the formation of the fibrous capsule in the FBR.

IPC Classes  ?

• A61L 27/28 - Materials for coating prostheses
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61K 31/095 - Sulfur, selenium or tellurium compounds, e.g. thiols
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Orthoorthostratum corneumNorthoortho-phthalaldehyde compound with cosmetically acceptable alcohols, oils, and modifiers.

IPC Classes  ?

• C07C 47/235 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
• A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen

Abstract

Disclosed herein are bacterial efflux inhibitor compounds and methods of using the compounds for treating bacterial infection.

IPC Classes  ?

• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61P 31/04 - Antibacterial agents
• C07D 207/08 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Abstract

A functionalized crosslinked acrylate copolymer is prepared by partially copolymerizing a composition that includes a first monomer that is monofunctional and has hydrophobic chain, a second monomer that is monofunctional and does not have a hydrophobic chain, and a third monomer that is di-, tri-, or poly functional. Relative to a corresponding copolymer without units derived from the first monomer, the present copolymer provides increased strength as-polymerized, and a further increase in strength over time on exposure to polar solvents, including water.

IPC Classes  ?

• C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
• C08F 220/54 - Amides
• C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
• C09J 133/10 - Homopolymers or copolymers of methacrylic acid esters
• C09J 133/26 - Homopolymers or copolymers of acrylamide or methacrylamide
• A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• C08F 220/06 - Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof

Abstract

Biocompatible, bistable or multistable (P-Type) photochromic or UV-absorbing nanoparticles or microparticles can be applied topically to the skin. The color of the topical body ink using the biocompatible and biodegradable bistable or multistable photochromic microparticles can be written, erased or changed, and re-written locally on the skin by irradiation with light of appropriate wavelengths. Formulations with much higher sensitivity to UV light than visible light can be used as short-term topical colorimetric UV dosimeters that can be reset and re-used on an hourly or daily basis. The topical body ink using the biocompatible UV-absorbing nanoparticles or microparticles provides skin protection against sunburn, photoaging, and skin cancers in a permanent or semi-permanent way, but remain clear in the visible light spectrum, or matched closely to the user's skin tone. These particles can be uniform aggregates or polymers containing P-type photochromic dyes or UV-absorbers, microencapsulated or core-shell structures, or solid particulate materials.

IPC Classes  ?

• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 8/85 - Polyesters
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61Q 1/02 - Preparations containing skin colorants, e.g. pigments
• C09B 11/02 - Diaryl- or triarylmethane dyes derived from diarylmethanes
• C09K 9/02 - Organic tenebrescent materials

Abstract

The disclosure provides systems and methods of 3D manufacturing of striation-free objects using volumetric additive manufacturing (VAM) techniques. The systems and methods include irradiation of a photocurable resin for a pre-gelation duration and subsequent energy delivery with a diffuse curing system to produce a 3D printed object without striations.

IPC Classes  ?

• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• B29C 64/268 - Arrangements for irradiation using electron beams [EB]
• B29C 64/291 - Arrangements for irradiation for operating globally, e.g. together with selectively applied activators or inhibitors
• B29K 105/00 - Condition, form or state of moulded material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor

Abstract

A testing apparatus includes a first section defining a recess to receive and align a transducer and an alignment protrusion. The testing apparatus further includes a second section hinge-ably coupled to the first section and defining a sample port and an alignment opening. The testing apparatus includes a gasket insert disposed within the sample port and defining at least one well configured to receive a fluid therein and align with a first portion of the transducer. A connector is coupled to the second section, the connector having a plurality of flexible or spring-loaded contact pins that align with a second portion of the transducer. The testing apparatus is movable between (i) an open configuration wherein the first section is disposed at an angle with respect to the second section and (ii) a closed configuration wherein the alignment protrusion is disposed within the alignment opening.

IPC Classes  ?

• G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

The invention relates to a composition comprising: at least one porous solid additive having a charged surface; an IL; a polymerizable IL; and a cross-linker; wherein the cross-linker wherein the cross-linker has a high affinity to CO2 over other light gas and comprises at least two polymerizable groups configured to react, in a radical polymerization reaction, with the polymerizable ionic liquid, said polymerizable groups preferably containing double bond.

IPC Classes  ?

• B01D 69/14 - Dynamic membranes
• B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/02 - Inorganic material
• B01D 71/40 - Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters

Abstract

A synchronous drive system for simultaneously driving more than two or more rotational tissue screws and a method for simultaneously affixing a medical device to tissue employing the synchronous drive system. The synchronous drive system is particularly configured to affix an apical cuff to cardiac muscle tissue by simultaneously driving a plurality of rotational tissue screws through the apical cuff and into cardiac muscle tissue thereby affixing the apical cuff to the cardiac muscle tissue.

IPC Classes  ?

• A61M 60/863 - Apex rings
• A61B 17/02 - Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
• A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
• A61B 17/3207 - Atherectomy devices
• A61B 17/34 - Trocars; Puncturing needles
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

A device and method for drilling a pilot hole within an object at a predetermined angle. The device includes a spacer having a lateral surface established by a first surface and a second surface and at least a portion of the lateral surface includes an extension. The extension having a proximal end and a distal end where the proximal end abuts the lateral surface and the distal end is configured to couple to a first end of a body. A guide body is also provided and is coupled to the device. The guide member includes a bore extending from a first end to a second end. Subsequent to disposing the spacer within the object, a drilling instrument may be disposed within the guide body thereby drilling out the pilot hole at the prescribed angle.

IPC Classes  ?

• A61B 17/17 - Guides for drills

Abstract

Embodiments of the present invention provide for novel compositions and methods for making and using thermostable enveloped viruses. Certain embodiments relate to formulating enveloped viruses alone in a aqueous formulation, or in combination with spray-drying, lyophilization or other drying techniques to reduce degradation and/or preserve activity or titer of the enveloped virus reducing titer loss, prolonging storage stability, delivery, and use. In some embodiments, formulations disclosed herein create a stabilized envelope virus formulation for protection from high temperature during drying processes for an enhanced and rapid drying process for storage, transport and later use of the stabilized envelope viruses.

IPC Classes  ?

• A61K 39/12 - Viral antigens

Abstract

Provided are inhibitors and combinations of inhibitors and chemotherapies for the treatment of cancer. The inhibitors may be CHD1L inhibitors and may bind to an allosteric binding site of CHD1L. The inhibitors may inhibit CHD1L autoactivation, CHD1L ATP-ase activity, inhibit tumor growth, trap CHD1L onto chromatin or a combination thereof. The combinations of CHD1L inhibitors and chemotherapies may improve the efficacy of the chemotherapies against drug-resistant cancers.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/505 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/33 - Heterocyclic compounds

Abstract

Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C12N 5/0789 - Stem cells; Multipotent progenitor cells
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof

Abstract

The present inventive concept relates to compounds and combinations for diagnosing and treating melanoma and methods related to the same involving combining MC1R-TRT and ICIs for melanoma treatment and provide novel treatments for metastatic melanoma. This inventive concept provides clinicians with novel valuable imaging tools to identify MC1R-positive patients who will benefit from the treatments, determine patient-specific dosimetry for safe and efficacious doses, and monitor patient responses to MC1R-TRT and ICIs treatments. This inventive concept will pave the way for use of this novel treatment in FDA-approved clinical trials, provide patients with personalized diagnoses and treatments, enhance diagnosis, treatment, and a cure for metastatic melanoma patients.

IPC Classes  ?

• C07K 7/54 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents
• C07K 14/68 - Melanocyte-stimulating hormone (MSH)

Abstract

Dynamic windows with adjustable tint give users greater control over flow of light and heat. Reversible metal electrodeposition dynamic windows include (i) a transparent or translucent conductive electrode; (ii) an electrolyte solution in contact with the electrode, the electrolyte solution comprising metal cations that are reversibly electrodeposited onto the transparent electrode upon application of a cathodic potential; and (iii) a counter electrode. The electrolyte solution advantageously includes a small amount of an additive (e.g., an inhibitor, an accelerator, a leveler, or an organic or inorganic molecule that similarly serves to enhance the surface morphology of the metal cations during reversible metal electrodeposition onto the transparent electrode). Such enhancement of surface morphology during the reversible electrodeposition of the metal tinting layer over the electrode enhances one or more of color neutrality, transmittance characteristics of visible wavelengths (e.g., ability to achieve a near 0% transmission privacy state), infrared reflectance, or switching speed.

IPC Classes  ?

• G02F 1/1506 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on an electrochromic effect based on electrodeposition, e.g. electrolytic deposition of an inorganic material on or close to an electrode
• B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
• C09K 9/00 - Tenebrescent materials, i.e. materials for which the range of wavelengths for energy absorption is changed as a result of excitation by some form of energy
• E06B 3/67 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges characterised by additional arrangements or devices for heat or sound insulation
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshine; Similar screens for privacy or appearance
• G02F 1/1343 - Electrodes
• G02F 1/15 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on an electrochromic effect
• G02F 1/155 - Electrodes

Abstract

A method of performing dynamic myelography and a dynamic myelography positioning device configured to alter the orientation of a patient easily and quickly. The device is configured to move a patient from a generally flat laying position into a sloped or partially sloped position. In some embodiments, the device is attachable or configured to rest upon an existing imaging table. The device includes a frame with a patient supporting structure integrated with or attached to the frame. A pivot mechanism having a rotational axis enables the two ends of the frame to fold towards each other. An actuator is in operable communication with the frame to control the degree of rotation of the ends of the frame about the rotational axis of the pivot mechanism.

IPC Classes  ?

• A61B 6/04 - Positioning of patients; Tiltable beds or the like
• A61G 13/12 - Rests specially adapted therefor; Arrangements of patient-supporting surfaces
• A61G 13/06 - Adjustable operating tables; Controls therefor raising or lowering of the whole table surface

Abstract

Embodiments of the instant disclosure relate to compositions and methods of making and using ATP-competitive Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) inhibitors for treating a health condition. In certain embodiments, the health condition includes, but is not limited to, a health condition concerning the brain, and targeting the brain with one or more ATP-competitive CaMKII inhibitor to prevent, ameliorate, or treat the health condition. In some embodiments, ATP competitive CaMKII inhibitors of use herein preserve, restore, or induce long-term potentiation (LTP) mechanisms in the subject. In some embodiments, the health condition includes a chronic health condition, and the treatment includes a prolonged treatment of a subject having such a chronic health condition.

IPC Classes  ?

• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

An assembly and method for end-to-side connection to anatomical tissue is disclosed. The system and method are particularly useful in coupling a ventricular assist device pump to an aorta. The assembly and method include using a tubular graft member coupled to a connection ring having at least one of a plurality of distally projecting tines extending from a distal aspect of the connection ring, and a stent having a distal flange section configured to abut an abluminal wall surface of the aorta, and an assembly including the tubular graft member and connection ring, for delivering the end-to-side connection.

IPC Classes  ?

• A61B 17/3205 - Excision instruments

Abstract

A method for microwave radiometry includes receiving, by a microwave probe, thermal radiation emitted by a sample. The method also includes amplifying an output of the microwave probe to generate an amplified signal, demodulating the amplified signal with a local-oscillator signal to obtain in-phase and quadrature signals, processing the in-phase and quadrature signals to generate a cross-correlation signal, detecting at least one of the in-phase and quadrature signals to generate a temperature signal, processing the temperature signal to at least partly determine a radiometric temperature of the sample, and outputting the radiometric temperature if the cross-correlation signal is less than a threshold.

IPC Classes  ?

• G01K 11/00 - Measuring temperature based on physical or chemical changes not covered by group , , , or
• A61B 5/0507 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
• A61B 5/01 - Measuring temperature of body parts
• G01K 13/20 - Clinical contact thermometers for use with humans or animals
• G01R 23/00 - Arrangements for measuring frequencies; Arrangements for analysing frequency spectra

Abstract

A curable composition includes a urethane (meth) acrylate monomer and an acidic or latent acidic comonomer. The urethane (meth) acrylate monomer includes 2 to 12 urethane groups and, independently, 2 to 12 (meth)acrylate groups, wherein each of at least two urethane groups is separated from at least one other urethane group or at least one urea group by at most three carbon atoms. The urethane (meth) acrylate monomer has a molecular weight less than or equal to 5,000 grams/mole. In the curable composition, the molar ratio of urethane groups in the urethane (meth) acrylate monomer to carboxylic acid and carboxylic acid anhydride groups in the acidic or latent acidic comonomer is 1:3 to 3:1.

IPC Classes  ?

• A61C 7/08 - Mouthpiece-type retainers
• C08F 222/10 - Esters
• C08G 18/28 - Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
• B29C 64/10 - Processes of additive manufacturing

Abstract

The present disclosure provides compositions and methods directed to logic gated CAR-T therapies for treating cancer, such as DIPG, Ewing Sarcoma, and AML, including logic pairs of CAR polypeptides comprising anti-CD56 CAR polypeptides and anti-CD99 CAR polypeptides.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 14/725 - T-cell receptors
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present disclosure provides compositions and methods directed to anti-CD99 CAR-T therapies for treating cancer, such as DIPG, Ewing Sarcoma, and AML.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 14/725 - T-cell receptors
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• C12N 15/01 - Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor

Abstract

Described herein are methods, systems and compositions for the production and use of a class of highly branched, nanostructured particles, generally referred to herein as dendritic particles (DPs), synthesized from biodegradable materials that are specifically adapted for drug release in vivo.

IPC Classes  ?

• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/44 - Non-condensed pyridines; Hydrogenated derivatives thereof
• A61K 31/505 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/33 - Heterocyclic compounds

Abstract

The inventive technology described herein includes a novel mechanical apparatus and system which allows centrifugation of small micron sized particles. The invention allows for continuous separation of ultrasound contrast agents (microbubbles) from lipid solution via centrifugation assisted by a motor. The system allows for mass isolation and collection of microbubbles. The invention also allows for the dispensation of lipid solution. In one preferred embodiment, dilute microbubble solution is introduced to the system and subjected to a centrifugal force such that the particles migrate towards the center and collectively rises for extraction, while the lipid solution dispenses and is replace with an equal volume of dilute solution. In one preferred embodiment, the device includes a rotating column or cylinder driven by a belt drive assembly, with the column being supported by annular bearings on both ends. The bearings allow rotation of the outer cylinder independent of stationary input cylinder and output components.

IPC Classes  ?

• B04B 11/02 - Continuous feeding or discharging; Control arrangements therefor
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• B04B 5/10 - Centrifuges combined with other apparatus, e.g. electrostatic separators; Sets or systems of several centrifuges
• B04B 9/00 - Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls

Abstract

The present disclosure relates to a device that includes a first metal oxide layer having a first thickness, a second metal oxide layer having a second thickness, and a base layer having a third thickness, where the first metal oxide layer is positioned between the base layer and the second metal oxide layer, at least one of the base layer and/or the first metal oxide layer includes a carbon-containing material, and at least one of a carbon concentration gradient and/or an oxygen concentration gradient is present across at least one of a portion of the first thickness and/or a portion of the third thickness. In some embodiments of the present disclosure, the first metal oxide layer may be permeable to an oxygen-containing compound. In some embodiments of the present disclosure, the oxygen-containing compound may include at least one of O3, N2O, and/or H2O2.

IPC Classes  ?

• H10K 30/82 - Transparent electrodes, e.g. indium tin oxide [ITO] electrodes
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers

Abstract

The present disclosure provides compositions and methods directed to logic gated CAR-T therapies for treating cancer, such as DIPG, Ewing Sarcoma, and AML, including logic pairs of CAR polypeptides comprising anti-CD276 CAR polypeptides and anti-CD99 CAR polypeptides.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 14/725 - T-cell receptors
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

The present disclosure relates in one aspect to constructs comprising a lipophilic membrane dye covalently linked through a linker to a cargo. In another aspect, the present disclosure relates to a method of delivering a cargo to a tumor in a subject in need thereof, the method comprising administering a construct of the disclosure to the subject. In certain embodiments, the tumor is a brain tumor.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/127 - Liposomes
• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

The invention includes systems and methods to chemically modify, and specifically functionalize the surfaces of elastomeric particles that can be used in various diagnostic and therapeutic applications. Additional embodiments of the invention include use of the functionalized elastomeric compositions to detect and isolate target analytes from heterologous fluid mixtures.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• C08L 83/04 - Polysiloxanes
• G01N 29/04 - Analysing solids
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings

Abstract

Transparent glazing materials, assemblies including the glazing material(s), and methods of forming and using the glazing materials and assemblies are provided. Exemplary glazing material comprising an aerogel that includes a network of cellulose nanofibers and silicon functional groups bonded to surfaces of the cellulose nanofibers.

IPC Classes  ?

• E06B 3/66 - Units comprising two or more parallel glass or like panes in spaced relationship, the panes being permanently secured together, e.g. along the edges
• E06B 3/663 - Elements for spacing panes

Abstract

A direction finding system can be configurable to: (i) access a baseline neural network initially configured to imitate behavior of a two-argument arctangent function; (ii) apply transfer learning to the baseline neural network to generate a calibrated neural network, wherein the transfer learning calibrates the baseline neural network to perform Watson-Watt direction finding without utilizing a lookup table for error correction; (iii) access measurement data acquired via the direction finding sensor array; (iv) generate preprocessed data by applying one or more preprocessing operations to the measurement data; (v) utilize the preprocessed data as input to the calibrated neural network; and (vi) output angle of arrival data, the angle of arrival data comprising output of the calibrated neural network.

IPC Classes  ?

• G01S 3/02 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using radio waves
• G01S 3/04 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using radio waves - Details

Abstract

A direction finding system includes a multi-arm spiral antenna configured to receive a signal, a processor, and a memory including instructions. When executed by the processor, the instructions cause an artificial intelligence (AI) algorithm to detect amplitudes of voltage of the signal received by the multi-arm spiral antenna, estimate, by the AI algorithm, an elevation angle of the signal based on a frequency and the amplitudes of voltages of the signal, estimate, by the AI algorithm, an azimuth angle based on the frequency, the elevation angle, and the amplitudes, determine, by the AI, a rotational offset based on the frequency and a rotational model, and calculate and output, by the AI algorithm, a direction of a source of the signal based on the rotational offset and the azimuth angle.

IPC Classes  ?

• G01S 3/14 - Systems for determining direction or deviation from predetermined direction
• H01Q 9/27 - Spiral antennas

Abstract

Methods of detecting various types of AMD and the likelihood of its progression to a more severe or advanced form of AMD involve detecting the presence or expression of one or more newly discovered AMD biomarkers contained within extracellular vesicles obtained from a subject. Biological samples containing the extracellular vesicles include fluid samples derived from plasma, urine, tears, saliva, or serum. Accurately diagnosing a particular form of AMD allows for the selection of treatment approaches not available or likely to be determined without the diagnosis.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection

Abstract

Embodiments described herein provide systems and methods for autoradiographic imaging for isotope discrimination of parent/progeny alpha or beta-emitters for targeted alpha- or beta- analysis and/or therapy. In certain embodiments, the systems and methods provide for an ability to image and distinguish biodistribution of parent isotopes from progeny isotopes. In certain embodiments, the parent isotope is an α-emitter isotopes (or b-emitter isotopes) useful for targeted α or b therapy, and the progeny/progeny isotopes can be α-emitting or b-emitting isotopes. In certain embodiments, such isotopes can be toxic to cells and tissues, and these isotopes can re-localize and damage non-target cells and tissues during use.

IPC Classes  ?

• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beam; Measurement of spatial distribution of radiation
• A61B 6/00 - Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
• G01T 1/164 - Scintigraphy
• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 3/06 - Measuring neutron radiation with scintillation detectors

Abstract

Chronological age is an important predictor of morbidity and mortality, however it is unable to account for heterogeneity in the decline of physiological function and health with advancing age. Several attempts have been made to instead define a “biological age” using multiple physiological parameters in order to account for variation in the trajectory of human aging; however, these methods require technical expertise and are likely too time-intensive and costly to be implemented into clinical practice. Accordingly, a metabolomic signature of biological aging was developed that can predict changes in physiological function with the convenience of a blood sample. A weighted model of biological age was generated based on multiple clinical and physiological measures in a large group of healthy adults and was then applied to a cohort of healthy older adults who were tracked longitudinally over a 5-10 year timeframe. Plasma metabolomic signatures were identified that were associated with biological age, including some that could predict whether individuals would age at a faster or slower rate. These results not only have clinical implications by providing a simple blood-based assay of biological aging, but also provide insight into the molecular mechanisms underlying human healthspan.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

Example systems and methods for providing an academic editor engine are provided herein. For example, an academic editor engine receives a request to revise a section of a scholarly manuscript. Responsive to the request, the academic editor engine determines a section type for the section. The academic editor engine then generates a prompt based on the section type and provides the prompt and the section to a content generator. The academic editor engine receives a revised section having revisions to the section from the content generator and provides a display of the revised section spatially proximate to the section to a client device. The academic editor engine receives an indication from the client device to accept one or more of the revisions as accepted revisions and generates a revised draft including the accepted revisions and an author attribution to the content generator for the accepted revisions.

IPC Classes  ?

• G06F 40/166 - Editing, e.g. inserting or deleting
• G06F 40/197 - Version control

Abstract

Systems and methods for generating and optimizing passive millimeter-wave (mmWave) attack tags are disclosed. In some implementations, optimizing a passive mmWave attack tag includes receiving parameters for a target and a scene of a mmWave attack, generating a set of initial parameters for a passive mmWave attack tag, determining an optimized set of parameters for the passive mmWave attack tag by iteratively modifying the set of initial parameters for the passive mmWave attack tag until a calculated attack loss is less than a predefined threshold or a maximum number of iterations is reached, and outputting the optimized set of parameters for the passive mmWave attack tag.

IPC Classes  ?

• G01V 15/00 - Tags attached to, or associated with, an object, in order to enable detection of the object
• G06K 7/00 - Methods or arrangements for sensing record carriers
• H04L 9/40 - Network security protocols
• G06K 19/00 - Record carriers for use with machines and with at least a part designed to carry digital markings
• F41G 7/00 - Direction control systems for self-propelled missiles
• G06F 18/00 - Pattern recognition
• G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation

Abstract

The preset invention is directed to systems, methods, and composition for the synthesis of 2'3'- cGAMP.

IPC Classes  ?

• C12N 1/00 - Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
• C12N 1/15 - Fungi ; Culture media therefor modified by introduction of foreign genetic material
• C12N 1/20 - Bacteria; Culture media therefor
• C12N 1/21 - Bacteria; Culture media therefor modified by introduction of foreign genetic material
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C07K 14/00 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
• C12N 9/00 - Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

Embodiments of the instant disclosure relate to novel compositions and methods for treating cancer in a subject. In certain embodiments, long noncoding RNAs (lncRNAs) are modified to reduce or eliminate methylation at target nucleotides within the lncRNAs to modulate activities such as tumor promoting activities. In some embodiments, the lncRNAs includes HOTAIR (HOX (homeobox) transcript antisense intergenic RNA) or fragment thereof, where one or more nucleotides are substituted to reduce or eliminate methylation at the one or more nucleotide positions. In certain embodiments, the HOTAIR methylation site includes, but is not limited to, a modification at adenine 783 (A783) of SEQ ID. NO:1 or fragment thereof or equivalent position thereof. In other embodiments, modified lncRNAs disclosed herein can be used to treat a health condition where naturally-occurring lncRNAs have adverse effects. In some embodiments, a composition including modified HOTAIR can be used to treat a subject with cancer.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Disclosed is a method for the synthesis of crystalline -graphyne which exhibits an ABC stacking pattern in the crystal structure. Alkyne metathesis is used to reversibly cleave and reform bonds between sp-hybridized carbon atoms to create an sp and sp2-hybridized carbon network. An exemplary method includes providing a first hexa-alkynyl substituted benzene co-monomer (e.g., HPB) and a second hexa-alkynyl substituted co-monomer (e.g., HHEB), and undergoing an alkyne metathesis reaction in the presence of a catalyst. During the reaction, small short chain alkyne byproducts can be removed, to drive the reaction toward the formation of the -graphyne polymer product, while the larger alkyne byproducts can facilitate the self-correction process that will minimize the structural defects in the resulting -graphyne.

IPC Classes  ?

• C01B 32/15 - Nanosized carbon materials

Abstract

This inventive technology includes systems, methods and compositions to detect 2'3'-cGAMP. In one preferred aspect, the invention is directed to one or more chimeric fusion peptides that are capable of coupling 2'3'-cGAMP analyte levels to an output, such as an enzymatic output.

Abstract

The present invention is directed to novel small-molecule inhibitors of PARN that were identified through high-throughput screening (HTS) of small molecule targets.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• C07D 487/04 - Ortho-condensed systems

Abstract

A method for determining soil moisture of a scene includes (i) generating a first antenna output in response to an upwelling thermal emission from the scene, (ii) generating a second antenna output in response to a downwelling thermal emission from sky above the scene, (iii) coupling the first antenna output and the second antenna output to yield a combined output having a quadrature phase difference between the first antenna output and the second antenna output, (iv) calculating a brightness-temperature difference based at least partially on the combined output, and (v) calculating a soil moisture based on soil-vegetation radiative transfer model using the brightness-temperature difference.

IPC Classes  ?

• G01N 22/04 - Investigating moisture content
• G01N 33/24 - Earth materials

Abstract

Improving photosynthesis and light capture increases crop yield and paves a sustainable way to meet the growing global food demand. A spectral-shifting microphotonic film is provided particularly for applications to improved plant growth, for example, as a greenhouse envelope. The spectral-shifting microphotonic film can be scalable manufactured for augmented photosynthesis. By breaking the intrinsic propagation symmetry of light, the photonic microstructures provided in the film can extract 89% of the internally generated light and deliver most of that into one direction towards photosynthetic organisms. The microphotonic film augments crop production (e.g., lettuce) by more than 20% in both indoor facilities with electric lighting and in a greenhouse with natural sunlight, providing a way to increase crop production efficiency in controlled environments.

IPC Classes  ?

• A01G 7/06 - Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
• A01G 9/14 - Greenhouses
• G02B 1/04 - Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
• G02B 3/00 - Simple or compound lenses

Abstract

Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Goods & Services

Educational services, namely, conducting classes and training targeting standardized patients that address DEI issues and inherent bias.

Abstract

A serpentine integrated grating spectrometer includes a serpentine delay line and a plurality of grating couplers. The serpentine delay line includes a plurality of parallel waveguide segments that are coplanar in a delay-line plane. The serpentine delay line serially connects each of the plurality of grating couplers. Each of the plurality of grating couplers (i) is located at a respective one of the plurality of parallel waveguide segments, and (ii) direct light propagating in the serpentine delay line out of the delay-line plane. The plurality of waveguide segments is M in number and impart a total group delay time ry on light propagating therethrough. Each of the plurality of grating couplers impart a grating coupler delay tx on light propagating therethrough that exceeds (ty/M), the time delay for a single segment of the M parallel segments.

IPC Classes  ?

• G02B 27/42 - Diffraction optics
• G01J 3/02 - Spectrometry; Spectrophotometry; Monochromators; Measuring colours - Details
• G01J 3/18 - Generating the spectrum; Monochromators using diffraction elements, e.g. grating
• G01J 3/28 - Investigating the spectrum
• G02B 5/18 - Diffracting gratings

Abstract

A three-dimensional (3D) printing apparatus includes: a light source comprising a plurality of pixels configured to emit a plurality of beams toward an optical objective; the optical objective configured to diverge the plurality of beams as the plurality of beams exits the optical objective toward a volume of resin; and one or more motors configured to translate the optical objective with respect to the volume of resin. The one or more motors are configured to translate the optical objective relative to the volume of resin to apply that plurality of beams to a plurality of voxels inside the volume of resin. The application of the plurality of beams to the plurality of voxels solidifies the plurality of voxels. The optical objective applies the plurality of beams such that each of the plurality of voxels are exposed by at least two different beams among the plurality of beams.

IPC Classes  ?

• B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
• B29C 64/282 - Arrangements for irradiation using multiple radiation means, e.g. micromirrors or multiple light-emitting diodes [LED] of the same type, e.g. using different energy levels
• B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
• G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts

Abstract

Diagnostic imaging of deep targets in the body requires sufficient signal amplitude to overcome effects such as attenuation with depth and thermal noise produced in signal reception. Coded excitation provides several strategies to increase the total transmitted energy without exceeding peak amplitude safety limits. Temporal coding has proven particularly effective, but these frequency or amplitude modulation techniques require additional transmit capabilities and often require complex processing to reduce decoding artifacts. An alternative code is presented based on time delays that relies on repeated transmit pulses that can be decoded using spatiotemporal synthetic aperture processing. A 16-pulse code is demonstrated that achieves an 11.1 dB improvement in signal-to-noise ratio (SNR) while maintaining axial resolution and sufficient range lobe performance. Further, a beamforming strategy for multiline transmission ultrasound data is presented that recognizes the data as time delay encoded and performs an appropriate decoding to reduce common reconstruction artifacts. This approach simultaneously enables synthetic aperture focusing of multiline transmission data, improving focusing through depth.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• G01S 7/52 - RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES - Details of systems according to groups , , of systems according to group

Abstract

Embodiments of the present disclosure provide novel compositions and methods for making and using thermostable bacteriophage or bacteriophage-derived phage-like-particle (PLP)-containing formulations. In certain embodiments, compositions and methods are disclosed for embedding, decorating and/or associating at least one antigen or agent, or bioactive molecule on the surface of the bacteriophage or PLPs. In accordance with these embodiments, bacteriophage or PLPs harboring one or more antigen or agent, or bioactive molecule can further be thermostabilized and/or coated with one or more atomic layer deposition applied coating layer for control or timed release of the one or more antigen or agent when administered to a subject.

IPC Classes  ?

• A61K 9/12 - Aerosols; Foams
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 9/50 - Microcapsules
• C12N 7/00 - Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof

Abstract

Embodiments of the present disclosure provide novel compositions and methods for making and using thermostable agent-containing lipid-emulsion formulations. In certain embodiments, compositions and methods are disclosed for adapting lipid nanoemulsions of agent-containing formulations having improved stability and/or retaining or enhancing immunogenicity. In other embodiments, agent-containing lipid-nanoemulsion formulations can be spray-dried and further embedded within glassy matrices or microparticles to improve stability and compatibility with other agents by limiting molecular mobility. In other embodiments, these microparticles harboring essentially dried stabilized agent-containing lipid-emulsion formulations can be coated by one or more coating layer to produce stabilized lipid nanoemulsions of agent-containing formulations. In some embodiments, the coating layer is applied by atomic layer deposition (ALD) and the coating layers include a metalloorganic material.

IPC Classes  ?

• A61K 9/12 - Aerosols; Foams
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 9/50 - Microcapsules