This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
C12Q 1/6837 - Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
Provided herein are methods and systems and related devices and compositions for electrochemical control of viability of redox active bacteria. The electrochemical control is performed by applying to a working electrode contacting a medium known or suspected to comprise the redox active bacteria, a reducing potential which is lower of the midpoint potential of a redox active compound produced by the redox active bacteria.
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
Disclosed herein is a composition for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a kit for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a method for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples.
In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61P 43/00 - Drugs for specific purposes, not provided for in groups
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
5.
TIMED AND/OR TARGETED CHLORATE ADMINISTRATION, AND RELATED MATRICES, COMPOSITIONS, IMPLANTS, METHODS AND SYSTEMS FOR PREVENTION AND/OR TREATMENT OF INFECTIONS
Methods and systems and related compositions, matrices and devices, for timed and/or targeted administration of chlorate for treatment and/or prevention of infections of a biological environment and related compositions, devices, matrices and implants. Chlorate administration can be performed alone or in combination with an antibiotic in a location and/or time targeted manner, the concentration and use of the chlorate and/or the antibiotic agents depending on the oxic/hypoxic/anoxic condition of the area being treated.
The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.
A system and method for joint dynamic interest request forwarding and dynamic cache placement and eviction and provided within the context of the Named Data Networking (NDN) architecture. The system and method employ a virtual control plane that operates on the user demand rate for data objects in the network, and an actual plane that handles Interest Packets and Data Packets. Distributed algorithms within the virtual plane achieve network load balancing through dynamic forwarding and caching, thereby maximizing the user demand rate that the NDN network can satisfy. A method of congestion control is also provided to achieve optimal network fairness using the VIP framework.
Disclosed herein arc methods that can be used to improve, treat and/or inhibit neurodevelopmental disorders in subjects in need, for example subjects suffering from Parkinson's disease. Some embodiments include administering an effective amount of fecal microbiota to the subject in need thereof, wherein the fecal microbiota is derived from healthy donors who are younger in age as compared to the subjects suffering from Parkinson's disease. Upon treatment, one or more symptoms of neurodevelopmental disorders can be improved in the subject.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
G01N 33/554 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
9.
MINIMAL STATE AUGMENTATION ALGORITHM FOR STEREO-VISION-BASED NAVIGATION
A method to perform vision based navigation on a moving vehicle. An image processor receives reference images with associated depth information as base frames or search frames. 2D features are detected in base frames and tracked in subsequent search frames. A new base frame is triggered when a number of features or a spatial distribution fall under thresholds. A depth processor reconstructs the depth and 3D position of each of the 2D features. A track manager manages a feature list database mapping the 2D coordinates of each tracked 2D feature with the 3D coordinate of that feature. A state manager constructs a filter state vector with 15 error states propagated at an IMU rate and 6 additional error states corresponding to clones of pose states. A visual updater utilizes the tracked 2D feature coordinates to update the filter state vector. A filter forms residuals and corrects inertial error drift.
G01C 21/28 - NavigationNavigational instruments not provided for in groups specially adapted for navigation in a road network with correlation of data from several navigational instruments
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06T 7/593 - Depth or shape recovery from multiple images from stereo images
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
10.
INVERTING EARTHQUAKE FOCAL MECHANISMS WITH DISTRIBUTED ACOUSTIC SENSING
The present invention infers the first-motion polarities using the relative polarities measured from cross-correlations. We demonstrate two real-world applications on two DAS arrays in the manuscript to illustrate the effectiveness of our method and improvements to the focal mechanism inversion.
G01V 1/22 - Transmitting seismic signals to recording or processing apparatus
E21B 41/00 - Equipment or details not covered by groups
G01D 5/353 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre
Disclosed herein include methods, compositions, and kits suitable for use in the measurement of the states of living cells across time and for use in the delivery of polyribonucleotides and circuits. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding reporter RNA molecule(s) or cargo RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising exported reporter RNA molecule(s) or a fusogen and exported cargo RNA molecule(s). Disclosed herein include export modulator proteins capable of, e.g., enhancing or suppressing LN export.
Disclosed herein are methods that can be used to improve, treat and/or inhibit neurodevelopmental disorders in subjects in need, for example subjects suffering from Parkinson's disease. Some embodiments include administering an effective amount of fecal microbiota to the subject in need thereof, wherein the fecal microbiota is derived from healthy donors who are younger in age as compared to the subjects suffering from Parkinson's disease. Upon treatment, one or more symptoms of neurodevelopmental disorders can be improved in the subject.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
The present application relates to hybridization chain reaction (HCR). The sensitivity and multiplexing of hybridization chain reaction (HCR) signal amplification are combined with target detection using barcode probes or barcode fusion probes, wherein a barcode probe or barcode fusion probe comprises a primary probe (comprising a target-binding domain) bound to a secondary probe (comprising a primary-probe-binding-domain and a barcode oligonucleotide comprising an HCR initiator or an HCR fractional initiator).
The present invention infers the first-motion polarities using the relative polarities measured from cross-correlations. We demonstrate two real-world applications on two DAS arrays in the manuscript to illustrate the effectiveness of our method and improvements to the focal mechanism inversion.
Systems and methods for transducing and storing qubit signals are provided. The system includes a voltage source, a substrate, and a membrane suspended over the substrate. A phononic crystal oscillator is disposed in a first region of the membrane. The phononic crystal oscillator includes a capacitor having a moving electrode including an array of multiple phononic crystal unit cells. The moving electrode is connected to the voltage source. A superconducting circuit disposed in a second region of the membrane. A plurality of phonon shields and an optical resonator may also be disposed on the membrane.
Disclosed herein include multivalent carriers comprising a plurality of heterologous coronavirus proteins antigens derived from different coronaviruses. The multivalent carriers herein described can elicit heterologous binding and neutralization properties against coronaviruses that differ from the coronaviruses from which the coronavirus antigens are derived to produce the multivalent carriers. Also provided herein include vaccine compositions comprising the multivalent carriers and related methods using the vaccine compositions in various therapeutic and prophylactic applications.
A method of correcting for crosstalk in thermo-optics phase shifters (TOPS) integrated on a substrate, includes, in part, determining a first value representative of an amount of electrical power applied to a heater associated with a first TOPS causing a known phase shift in an optical signal passing through the first TOPS' associated waveguide; determining a second value representative of a time constant of the first TOPS; determining a third value representative of an amount of electrical power applied to a heater associated with a second TOPS causing a known phase shift in an optical signal passing through the waveguide associated with the first TOPS; determining a multitude of thermal couplings between a multitude of heaters, waveguides and positions in the substrate using one or more of the first, second and third values; and making a correction associated with the crosstalk in accordance with the thermal couplings.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
19.
MOLECULAR DETECTION USING BARCODE PROBES OR BARCODE FUSION PROBES AND HYBRIDIZATION CHAIN REACTION
The present application relates to hybridization chain reaction (HCR). The sensitivity and multiplexing of hybridization chain reaction (HCR) signal amplification are combined with target detection using barcode probes or barcode fusion probes, wherein a barcode probe or barcode fusion probe comprises a primary probe (comprising a target-binding domain) bound to a secondary probe (comprising a primary-probe-binding-domain and a barcode oligonucleotide comprising an HCR initiator or an HCR fractional initiator).
Systems and methods for a wearable stress response assessment system may include aniontophoresis module, a multi-inlet microfluidic sweat sampling component, and a sensor patchconfigured to detect concentrations of electrolytes and metabolites present in a sweat sample andmonitor physiological signs prevalent in a human patient. An iontophoresis module may providefor stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may beachieved via electrostimulation and/or application of a stimulating agent. A microfluidic sweatsampling component may include adhesive and PDMS layers with carefully designed inlets andchannels for efficient collection and sampling of biofluid. Enzymatic and ISE biosensors mayquickly and accurately identify concentrations of key biomarkers present in a biofluid samplewhich may assess, in combination with monitored physiological signs, a human patient's stressresponse.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 5/16 - Devices for psychotechnicsTesting reaction times
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
The present disclosure provides methods for the scalable amplification of the signal of an analyte in a sample for the spatial localization of the analyte in a biological sample. This disclosure sets forth methods, in addition to using the same, and other solutions to problems in the relevant field.
A computer-implemented method useful for performing seismic tomography, including obtaining seismic data comprising distributed acoustic sensing (DAS) data, comprising at least one of P-wave or S-wave travel times from a plurality of seismic events to a plurality of recording stations coupled to a network of optical fibers in a geological structure; and generating tomography data from the DAS data, wherein tomography data is useful for characterizing the geological structure. We employ distributed acoustic sensing data recorded along a 100-km fiber-optic cable traversing the caldera to image its subsurface structure. Our images highlight a definite separation between the shallow hydrothermal system and the large magma chamber located at ˜12 km depth. The combination of the geological evidence with our results shows how fluids exsolved through second boiling provide the source of the observed uplift and seismicity. Thus Fiber-seismic tomography reveals that the unrest in the Long Valley Caldera is likely driven by fluid from second boiling, not new magma intrusion.
A device including a stack of silicon meta-optical layers forming a meta-material comprising an input surface for receiving terahertz electromagnetic radiation, an output surface for outputting a plurality of beams of the electromagnetic radiation; and a spatially varying permittivity varying with sub-wavelength precision across a volume of the stack, wherein the spatially varying permittivity is configured to focus different spectral bands of the electromagnetic radiation into different spatially separated electromagnetic modes.
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
C10G 50/00 - Production of liquid hydrocarbon mixtures from lower carbon number hydrocarbons, e.g. by oligomerisation
A computer-implemented method useful for performing seismic tomography, including obtaining seismic data comprising distributed acoustic sensing (DAS) data, comprising at last one of P-wave or S-wave travel times from a plurality of seismic events to a plurality of recording stations coupled to a network of optical fibers in a geological structure; and generating tomography data from the DAS data, wherein tomography data is useful for characterizing the geological structure. We employ distributed acoustic sensing data recorded along a 100-km fiber-optic cable traversing the caldera to image its subsurface structure. Our images highlight a definite separation between the shallow hydrothermal system and the large magma chamber located at ~12 km depth. The combination of the geological evidence with our results shows how fluids exsolved through second boiling provide the source of the observed uplift and seismicity. Thus Fiber-seismic tomography reveals that the unrest in the Long Valley Caldera is likely driven by fluid from second boiling, not new magma intrusion.
Systems and methods for activating mechanochemical reactions remotely using biocompatible ultrasound in the presence of gas-filled structures are described. The collapse of gas-filled structures is achieved using biocompatible ultrasound. In turn, collapse of the gas-filled structures can mechanochemically activate mechanophore-functionalized polymers in solution. Mechanochemical activation of mechanophore-functionalized polymers under physiological conditions can trigger the release and/or delivery of a variety of cargos with the spatial and temporal precision and deep tissue penetration afforded by focused ultrasound.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
28.
VOLUMETRIC SILICON META-OPTICS FOR COMPACT AND LOW-POWER TERAHERTZ SPECTROMETERS
A device including a stack of silicon meta-optical layers forming a meta-material comprising an input surface for receiving terahertz electromagnetic radiation, an output surface for outputting a plurality of beams of the electromagnetic radiation; and a spatially varying permittivity varying with sub-wavelength precision across a volume of the stack, wherein the spatially varying permittivity is configured to focus different spectral bands of the electromagnetic radiation into different spatially separated electromagnetic modes.
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.
A device implementing a nonlinear activation function including a material having nonlinear susceptibility phase-matching a coherent nonlinear interaction involving a signal comprising a signal wavelength and a bias comprising a bias wavelength, so that (1) a first phase difference between the signal and the bias induces the interaction comprising second harmonic generation (generating a second harmonic of the bias wavelength) or sum frequency generation (generating a sum frequency of the bias and the signal, and (2) a second phase difference between the signal and the bias induces the interaction comprising parametric amplification amplifying the bias and attenuating the signal. A positive input to the nonlinear activation function is represented by the signal having an input energy and the first phase difference. A negative input is represented by second phase difference. The output is an output energy of the signal as function of the input energy.
A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or semiconductor, and the second region comprises a metallic electrical conductor. The second region extends through the solid and a subset of said second region comprise surface metal unit cells that are adjacent to at least one unit cell from the first region. The ratio of the number of said surface metal unit cells to the total number of unit cells in the second region being at least 20 percent.
C04B 35/45 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on copper oxide or solid solutions thereof with other oxides
C04B 35/626 - Preparing or treating the powders individually or as batches
Systems and devices for dynamic damping of vibrations are described. Traditional methods of vibration damping often involve trade-offs between stiffness and damping, potentially compromising structural integrity for increased damping. The performance of these damping techniques can also be influenced by the specific profile of the vibrational excitation, presenting challenges in ensuring consistent and reliable damping across different operating conditions. A tunable friction-damping device formed from concentric layers can overcome many of these limitations and presents methods for dynamic damping of vibrations as an alternative solution.
F16F 15/121 - Suppression of vibrations in rotating systems by making use of members moving with the system using elastic members or friction-damping members, e.g. between a rotating shaft and a gyratory mass mounted thereon using springs as elastic members, e.g. metallic springs
F16F 1/10 - Spiral springs with turns lying substantially in plane surfaces
A sensor including a resonator comprising a nonlinear material comprising a nonlinear susceptibility configured to convert a pump electromagnetic wave (EM) wave to a signal EM wave and an idler EM wave, wherein at least one of the pump EM wave, the signal EM wave and/or the idler EM wave is fed back through the nonlinear material to form one or more resonant EM waves. An actuator coupled to the resonator or a pump path to the resonator, controls at least one of a pump power of the pump EM wave, a detuning of the frequency modes of the resonator relative to one or more frequencies of the resonant EM waves, or a phase matching of the nonlinear material. An output of the resonator outputs one or more output EM waves comprising information about a sample coupled to the resonator.
Cross-ray ultrasound tomography systems and methods that employ an ultrasonic emitter and an ultrasonic detector array where the ultrasonic emitter is outside a plane at elements of the ultrasonic detector array, and ultrasonic wave(s) are emitted by the ultrasonic emitter at an angle to the plane at the elements of the ultrasonic detector array.
A method of operating a mass spectrometer including an ion trap is provided. The method comprises introducing an ion having a mass to charge ratio into the ion trap; measuring time series data corresponding to the oscillation of the ion in the ion trap; extracting a first feature indicative of the oscillation of the ion in the ion trap and a second feature indicative of a trajectory of the oscillation of the ion from the time series data; and computing the mass to charge ratio using an ion trap function and the extracted first and second features.
Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.
An apparatus including a source of electromagnetic radiation comprising one or more first frequencies; a source of an input signal comprising an alternating (AC) electric field comprising one or more second frequencies; a control circuit synchronizing application of the electromagnetic radiation and the AC electric field applied to a sample, so that an output signal comprising a modulation of the AC electric field is outputted from the sample in response to (1) the one or more second frequencies tuned to drive hopping of ions between ion sites in the sample, and the one or more first frequencies tuned to drive excitations in the sample that interact with the ions. The apparatus further includes a detection system measuring and/or detecting a change in the output signal in response to the electromagnetic radiation; and a computer determining at least one of a conductivity or impedance of the sample from the output signal and as a function of the first frequencies and the second frequencies.
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
39.
INSTRUCTIONAL POINT OF CARE DEVICE FOR SAMPLE HANDLING
An interactive modular device for instructing and assisting users on sample handling processes using features to guide a user through the processes in real time. The modules of the device include a processing module (e.g., pooling module), a sample-container module (e.g., tube module), a container-closure module (e.g., cap module), a sample-transfer module (e.g., pipette module), a scanning module (e.g., single barcode module), a multi-scanning module (e.g., multi-barcode module), a waste container module, and a display module. The features include mechanisms to determine presence and absence of items used for sample handling and visual, audible, and tactile indicators in real time.
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 90/96 - Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text using barcodes
40.
HYBRID METHOD FOR FAST FUNCTIONAL IMAGING WITH SPARSE SAMPLING IN TOMOGRAPHY
An interactive modular device for instructing and assisting users on sample handling processes using features to guide a user through the processes in real time. The modules of the device include a processing module (e.g., pooling module), a sample-container module (e.g., tube module), a container-closure module (e.g., cap module), a sample-transfer module (e.g., pipette module), a scanning module (e.g., single barcode module), a multi-scanning module (e.g., multi-barcode module), a waste container module, and a display module. The features include mechanisms to determine presence and absence of items used for sample handling and visual, audible, and tactile indicators in real time.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
42.
LIQUID FLOW INDUCED POWER GENERATION USING NANOSCALE METAL LAYERS
Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer.
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
CALIFORNIA INSTITUTE OF TECHNOLOGY (USA)
Inventor
Wygnanski, Israel
Taubert, Lutz
Graff, Emilio
Gharib, Morteza
Abstract
Conventional moving control surfaces on a typical tailless aircraft are replaced with sweeping Jet Actuators ("SJAs") for Active Flow Control ("AFC"). However, a large quantity of SJAs may be necessary in each array and efficacy of SJAs has only been demonstrated at low speeds (i.e., Mach 0.2 or less). In this disclosure, Supersonic Steady Jets (SSJs) are used as control surface replacements for aircraft. The SSJs are distributed on the aircraft in locations and orientations that take into consideration changing local flow conditions on the surface of the aircraft. In one example, when a single SSJ was used to control the pitch of the aircraft, the single SSJ increased the trimmed lift of the aircraft almost as well as an array of SJAs, while providing better yaw control at a small accompanying rolling moment.
44.
HIGH-RESOLUTION WHOLE GENOME IMAGING BY NUCLEIC ACID LOCUS AND BLOCK CODING
The present disclosure provides methods for analyzing genomic structures by diffraction limited locus imaging and nucleic acid block coding. The methods allow efficient and scalable imaging, which can be applied to multiplexed RNA/DNA fluorescence in situ hybridization (FISH).
Certain aspects pertain to intra-image motion correction methods and systems configured to divide an image domain into subdomains and estimate motion of each subdomain along one or more axes and determine a motion corrected image based on the motions.
Aspects of the invention include a method of producing a cement material comprising step of: first reacting a calcium-bearing starting material with a first acid to produce an aqueous first calcium salt; second reacting the aqueous first calcium salt with a second acid to produce a solid second calcium salt; wherein the second acid is different from the first acid and the second calcium salt is different from the first calcium salt; and thermally treating the second calcium salt to produce a first cement material. Preferably, but not necessarily, during the second reacting step, reaction between the first calcium salt and the second acid regenerates the first acid.
C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
C07C 1/32 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero atoms other than, or in addition to, oxygen or halogen
47.
SPLIT AND POOL IDENTIFICATION OF RBP TARGETS (SPIDR)
The Trustees of Columbia University in the City of New York (USA)
Inventor
Wolin, Erica
Guo, James
Guttman, Mitchell
Jovanovic, Marko
Abstract
Aspects of the present disclosure generally relate to methods and compositions for detecting an association between a RNA binding protein and a RNA. Some aspects of the present disclosure relate to methods of generating an antibody-bead conjugate pool. Some aspects of the present disclosure relate to kits and compositions for performing the methods disclosed herein.
Disclosed herein include novel blood-brain barrier (BBB)-crossing receptors on the BBB interface, targeting peptides and derivatives thereof capable of binding to the novel receptors, and related methods of using the receptors to increase the permeability of the BBB and to deliver an agent to a nervous system (e g.. CNS).
49.
SYSTEMS AND METHODS FOR MINIATURE SPATIAL HETERODYNE SPECTROMETRY
Systems and methods for miniature spatial heterodyne spectrometer (SHS) systems are described. Methods for optimizing the miniature SHS systems can reduce the sizes and format while achieving high sensitivity and detection quality. The miniature SHS systems can be deployed for handheld use in real-world or remote activities outside of research or diagnostic facilities.
A device including a photonic integrated circuit comprising one or more OPOs each comprising: an input configured to receive a pump wave comprising pulses or a frequency comb with a pump repetition rate, one or a plurality of nonlinear sections as part of a resonator or coupled to a resonator having a free spectral range, where at least one of the free spectral range or one of its harmonics is matched to the pump repetition rate or its harmonics, and one or a plurality of outputs configured to extract a portion of the waves generated by the OPO in response to the pump wave and/or the pump wave.
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (USA)
Inventor
Wolin, Erica
Guo, James
Guttman, Mitchell
Jovanovic, Marko
Abstract
Aspects of the present disclosure generally relate to methods and compositions for detecting an association between a RNA binding protein and a RNA. Some aspects of the present disclosure relate to methods of generating an antibody-bead conjugate pool. Some aspects of the present disclosure relate to kits and compositions for performing the methods disclosed herein.
A device including a continuous (CW) wave source of pairs of entangled photons, each pair comprising a first photon entangled with a second photon; a pair of channels comprising a first channel terminated by a first detector configured to detect the first photon and a second channel terminated by a second detector configured to detect a output photon emitted by an excited state of matter excited by the second photon in the second channel; a splitter for splitting the pairs of entangled photons into the channels, so that the first photon comprising a reference photon is transmitted to the first channel and the second photon is transmitted to the second channel; and a timing circuit coupled to the detectors operable to measure a time delay between arrival times measured at the detectors of the output photon and the first photon entangled with the second photon used to generate the output photon (e.g., fluorescence photon).
A leak-detection system comprises networked imaging packages including an infrared camera based on microbolometer arrays, one or more filters, and a processor. The processor uses one or more novel processing methods for identifying gas leakages in a monitored facility. In some embodiments, the imaging packages are installed at various locations in the monitored facility. In some other embodiments, the leak-detection system is embodied as a mobile platform, wherein the networked imaging packages are coupled to drones that fly throughout the monitored facility to monitor for gas leakages. The flight path of the cameras may be pre-programmed and may further be alterable in real time. The novel processing technique(s) employed by the leak-detection system disclosed herein involve the use of multiple unique filters that facilitate enhancing the signal-to-noise ratio of captured images; that is, enhancing the contrast of a monitored gas against other objects. The novel processing techniques include one or more of the following: (i) two-image subtraction; (ii) time-resolved imaging; and (iii) multi-filter detection. Additionally, in some embodiments, the imaging packages include a visible (light) camera in addition to an IR camera.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01J 3/51 - Measurement of colourColour measuring devices, e.g. colorimeters using electric radiation detectors using colour filters
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
A device including a continuous wave source of pairs of entangled photons, each pair comprising a first photon entangled with a second photon; a pair of channels comprising a first channel terminated by a first detector configured to detect the first photon and a second channel terminated by a second detector configured to detect a output photon emitted by an excited state of matter excited by the second photon in the second channel; a splitter for splitting the pairs of entangled photons into the channels, so that the first photon comprising a reference photon is transmitted to the first channel and the second photon is transmitted to the second channel; and a timing circuit coupled to the detectors operable to measure a time delay between arrival times measured at the detectors of the output photon.
SYSTEMS AND METHODS FOR MONITORING THE SURFACE TEMPERATURE OF AN OBJECT USING AN IMAGER AND THE TEMPERATURE-DEPENDENT ABSORPTION PROPERTIES OF SEMICONDUCTORS
A temperature monitoring system includes a semiconductor member mounted onto the surface of an object having a surface whose temperature is to be monitored. The semiconductor member has a temperature-dependent bandgap with an absorption edge that varies with temperature. A light source is configured to illuminate the semiconductor member with monochromatic light. The monochromatic light has a wavelength equal to an absorption edge wavelength that is associated with the absorption edge when the semiconductor member is at a specified temperature. An imaging device is configured to receive light reflected from the semiconductor member when illuminated with the monochromatic light such that a surface temperature of the object is at the specified temperature when a change in an amount of reflected light that is received indicates that the wavelength of the monochromatic light is equal to the absorption edge wavelength at the specified temperature.
G01K 11/125 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in colour, translucency or reflectance using changes in reflectance
G01K 13/00 - Thermometers specially adapted for specific purposes
G01K 1/02 - Means for indicating or recording specially adapted for thermometers
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
56.
LEAK-DETECTION SYSTEM AND METHODS FOR LEAK DETECTION
A leak-detection system comprises networked imaging packages including an infrared camera based on microbolometer arrays, one or more filters, and a processor. The processor uses one or more novel processing methods for identifying gas leakages in a monitored facility. In some embodiments, the imaging packages are installed at various locations in the monitored facility. In some other embodiments, the leak-detection system is embodied as a mobile platform, wherein the networked imaging packages are coupled to drones that fly throughout the monitored facility to monitor for gas leakages. The flight path of the cameras may be pre-programmed and may further be alterable in real time. The novel processing technique(s) employed by the leak-detection system disclosed herein involve the use of multiple unique filters that facilitate enhancing the signal-to-noise ratio of captured images; that is, enhancing the contrast of a monitored gas against other objects. The novel processing techniques include one or more of the following: (i) two-image subtraction; (ii) time-resolved imaging; and (iii) multi-filter detection. Additionally, in some embodiments, the imaging packages include a visible (light) camera in addition to an IR camera.
G01M 3/38 - Investigating fluid tightness of structures by using light
G06V 10/88 - Image or video recognition using optical means, e.g. reference filters, holographic masks, frequency domain filters or spatial domain filters
57.
SYNTHETIC MAMMALIAN SIGNALING CIRCUITS FOR ROBUST CELL POPULATION CONTROL
Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.
C12N 9/86 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
58.
MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO
Disclosed herein include methods, compositions, and kits enabling expression of multiple payload proteins from a single mRNA configured to achieve a predetermined stoichiometry of first unit payload protein(s) and second unit payload protein(s) in a cell or cell-like environment. There are provided, in some embodiments, nucleic acid compositions comprising a polynucleotide comprising a first nucleic acid unit (encoding one or more first unit payload protein(s)) and a second nucleic acid unit (encoding one or more second unit payload protein(s)). The first nucleic acid unit and the second nucleic acid unit can each comprise an engineered translation initiation site (eTIS) comprising a three-nucleotide tunable element immediately upstream of a start codon. In some embodiments, the nucleic acid composition comprises at least one modified nucleotide and/or at least one nucleotide analogue or nucleotide derivative. In some embodiments, the polynucleotide comprises a disclosed eTIS combination.
Systems and methods for a self-powered wireless wearable sensor system include a freestanding triboelectric nanogenerator (FTENG), used as a power source for a wearable sensor. The FTENG includes stator panels and corresponding slider panels with a grating pattern. Movement, such as cardiovascular exercise causes the slider panel(s) to slide across the stator panel(s) inducing a charge and powering a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system includes a microfluidic sweat sensor patch which may be connected to lower-power wireless sensor circuitry for regulating power efficiently and is powered by the FTENG.
Disclosed herein include methods, compositions, and kits enabling expression of multiple payload proteins from a single mRNA configured to achieve a predetermined stoichiometry of first unit payload protein(s) and second unit payload protein(s) in a cell or cell-like environment. There are provided, in some embodiments, nucleic acid compositions comprising a polynucleotide comprising a first nucleic acid unit (encoding one or more first unit payload protein(s)) and a second nucleic acid unit (encoding one or more second unit payload protein(s)). The first nucleic acid unit and the second nucleic acid unit can each comprise an engineered translation initiation site (eTIS) comprising a three-nucleotide tunable element immediately upstream of a start codon. In some embodiments, the nucleic acid composition comprises at least one modified nucleotide and/or at least one nucleotide analogue or nucleotide derivative. In some embodiments, the polynucleotide comprises a disclosed eTIS combination.
Disclosed herein include methods and related systems of bond-selective fluorescence-detected infrared-excited (BonFIRE) spectroscopy. BonFIRE employs two-photon excitation in the mid-IR and near-IR to upconvert vibrational excitations to electronic states for fluorescence detection, thus encoding vibrational information into fluorescence. The method comprises providing a sample comprising a dye molecule having an UV-vis absorption maximum; generating an IR laser and a NIR laser, wherein the IR laser and the NIR laser are coherent; aligning the IR laser and the NIR laser in a counter-propagating configuration on the sample; irradiating the dye molecule with the IR laser and the NIR laser; and detecting a fluorescence from the dye molecule which can be used to extract a bond-selective IR absorption maximum of the dye molecule or form an image of the sample from the fluorescence with single-molecule sensitivity. The WF-BonFIRE technique significantly increases the imaging speed for single-molecule samples and for biological samples.
An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
H01M 8/16 - Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
63.
METHODS AND SYSTEMS FOR BOND-SELECTIVE FLUORESCENCE-DETECTED INFRARED-EXCITED IMAGING
Disclosed herein include methods and related systems of bond-selective fluorescence-detected infrared-excited (BonFIRE) spectroscopy. BonFIRE employs two-photon excitation in the mid-IR and near-IR to upconvert vibrational excitations to electronic states for fluorescence detection, thus encoding vibrational information into fluorescence. The method comprises providing a sample comprising a dye molecule having an UV-vis absorption maximum; generating an IR laser and a NIR laser, wherein the IR laser and the NIR laser are coherent; aligning the IR laser and the NIR laser in a counter-propagating configuration on the sample; irradiating the dye molecule with the IR laser and the NIR laser; and detecting a fluorescence from the dye molecule which can be used to extract a bond-selective IR absorption maximum of the dye molecule or form an image of the sample from the fluorescence with single-molecule sensitivity. The WF-BonFIRE technique significantly increases the imaging speed for single-molecule samples and for biological samples.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
64.
ELECTROCHEMICAL INHIBITION OF REDOX ACTIVE BACTERIA AND RELATED DEVICES, METHODS AND SYSTEMS
Provided herein are methods and systems and related devices and compositions for electrochemical control of viability of redox active bacteria. The electrochemical control is performed by applying to a working electrode contacting a medium known or suspected to comprise the redox active bacteria, a reducing potential which is lower of the midpoint potential of a redox active compound produced by the redox active bacteria.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
66.
DEEP NEURAL NETWORKS FOR OUTCOME-ORIENTED PREDICTIONS
Among the various aspects of the present disclosure is the provision of deep neural networks for outcome oriented predictions. For an example, a method comprising: receiving a microscopy image associated with a test sample; identifying a region of interest of the microscopy image for analysis; randomly selecting a set of sub-images from within the region of interest; generating a set of outcome predictions, each outcome prediction associated with a corresponding sub-image of the set of sub-images by providing the suh-image to a trained deep neural network; aggregating the outcome predictions of the set of outcome predictions to generate an aggregate outcome prediction; and providing the aggregate outcome prediction associated with the microscopy image.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 30/00 - ICT specially adapted for the handling or processing of medical images
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A device including a chip including a photonic integrated circuit comprising an external cavity for a source of electromagnetic radiation; the source of electromagnetic radiation attached to a top surface of the chip, the source comprising a semiconductor active region comprising, or coupled to, an output for the electromagnetic radiation, wherein the output is oriented to emit the electromagnetic radiation into the top surface in an emission direction that is inclined with respect to a plane of propagation of the electromagnetic radiation in the external cavity; and a coupler coupling the active region to the external cavity via the top surface to integrate the external cavity with the active region. The coupler partially couples the electromagnetic radiation outputted from the active region to the external cavity, and feedback from the external cavity to the active region.
H01S 5/183 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only vertical cavities, e.g. vertical cavity surface-emitting lasers [VCSEL]
H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
H01S 5/20 - Structure or shape of the semiconductor body to guide the optical wave
69.
DIRECT CURRENT- 40 GIGAHERTZ COAX-BASED CRYOGENIC VARIABLE TEMPERATURE LOAD (VTL) WITH EXCEPTIONAL TEMPORAL RESPONSE AND LINEARITY
A variable temperature load (VTL) or noise source including a grounded coplanar waveguide (GCPW) comprising a first metallization patterned on a fused quartz substrate, the first metallization comprising a first end for connecting to a coaxial connector and a second end for connecting to a coplanar waveguide (CPW); the CPW coupled to a 50 ohm termination and comprising a second metallization patterned on a top surface of a crystal quartz substrate; a temperature sensing diode thermally coupled to the crystal quartz substrate and the second metallization; and a heater resistor coupled to the crystal quartz substrate via contact metallization.
Photoacoustic imaging techniques that deliver diffuse light in transmission mode to the brain and detect acoustic waves transmitted through an acoustic window in the skull.
A method of preparing an organosilicon compound having at least one silicon-bonded carbinol group and/or at least one silanol group with a cytochrome P450 variant that facilitates the oxidization of a silicon-bonded hydrocarbyl group in the presence of an oxidant. The method includes combining the cytochrome P450 variant, an initial organosilicon compound having at least one silicon-bonded hydrocarbyl group, and a cofactor to give a reaction mixture, and exposing the reaction mixture to an oxidant to oxidize the silicon-bonded hydrocarbyl group of the initial organosilicon compound, thereby preparing the organosilicon compound having at least one silicon-bonded carbinol group and/or at least one silanol group. Cytochrome P450 variants suitable for use in the method are also disclosed, along with methods for engineering and optimizing the same. Nucleic acids encoding the cytochrome P450 variants and compositions, expression vectors, and host cells including the same are also disclosed.
A device including a chip including a photonic integrated circuit comprising an external cavity for a source of electromagnetic radiation; the source of electromagnetic radiation attached to a top surface of the chip, the source comprising a semiconductor active region comprising, or coupled to, an output for the electromagnetic radiation, wherein the output is oriented to emit the electromagnetic radiation into the top surface in an emission direction that is inclined with respect to a plane of propagation of the electromagnetic radiation in the external cavity; and a coupler coupling the active region to the external cavity via the top surface to integrate the external cavity with the active region. The coupler partially couples the electromagnetic radiation outputted from the active region to the external cavity, and feedback from the external cavity to the active region.
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
Some implementations of the disclosure relate to a wearable biosensor device including: a microfluidic module configured to collect a sweat sample from skin of a user, route the sweat sample to a sensing reservoir that is filled with the sweat sample, and route additional sweat away from the sensing reservoir when the sensing reservoir is filled; and a sensor assembly configured to quantify the biomarker of the sweat sample in the sensing reservoir to determine a concentration of the biomarker present in the sweat sample. The sensor assembly includes a biorecognition interface having a surface functionalized with an aptamer that binds to the biomarker.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
80.
TECHNIQUES FOR BIDIRECTIONAL TRANSDUCTION OF QUANTUM LEVEL SIGNALS BETWEEN OPTICAL AND MICROWAVE FREQUENCIES USING A COMMON ACOUSTIC INTERMEDIARY
A device includes an opto-acoustic transducer configured to convert between an optical signal and an acoustic signal, an electro-acoustic transducer coupled to a microwave resonant circuit and configured to convert between an acoustic signal and a microwave signal, and an acoustic waveguide coupling the opto-acoustic transducer to the electro-acoustic transducer.
B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
B82Y 40/00 - Manufacture or treatment of nanostructures
G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices
G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena
G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
G11C 13/02 - Digital stores characterised by the use of storage elements not covered by groups , , or using elements whose operation depends upon chemical change
81.
METHOD AND SYSTEM FOR OBSERVING BRAIN STATES WITH FUNCTIONAL ULTRASOUND IMAGING AND A SONOLUCENT INTERFACE
A cranial implant that facilitates functional ultrasound imaging is disclosed. The example cranial implant replaces a section of a skull. The cranial implant in includes a support section shaped to replace a removed section of the skull. The implant includes a window of sonolucent material allowing functional ultrasound imaging through an ultrasound probe on the window. The window is shaped to allow access to a region of interest in the brain from the ultrasound probe.
Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.
A61B 5/245 - Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies
83.
Si-SUBSTITUTED LITHIUM THIOBORATE MATERIAL WITH HIGH LITHIUM ION CONDUCTIVITY FOR USE AS SOLID-STATE ELECTROLYTE AND ELECTRODE ADDITIVE
Aspects disclosed herein include materials comprising: a lithium thioborate composition characterized by formula FX1: Li3−z[B+Q]1[S+G]3 (FX1); wherein Q is a first dopant being a substitute for B in the composition and being one or more elements each aliovalent with respect to B; wherein G is a second dopant being a substitute for S in the composition and being one or more elements each aliovalent with respect to S; wherein z is a number greater than 0 and less than or equal to 0.40, optionally less than or equal to 0.05; and wherein the composition comprises only the first dopant, only the second dopant, or both the first dopant and the second dopant.
Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
Disclosed herein include methods, compositions, and kits suitable for use in determining the interaction between proteins and their targets. In some embodiments, the determination of the interaction between proteins and their targets is quantitative and in a high throughput manner.
Disclosed herein include methods, compositions, and kits suitable for use in determining the interaction between proteins and their targets. In some embodiments, the determination of the interaction between proteins and their targets is quantitative and in a high throughput manner.
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
Systems and alloying methods for forming metals are described. Waste materials from various industrial processes and botched master alloy production heats result in numerous byproducts that can form constituent components for the formation of bulk alloys with higher value and more diverse applications. Reusing and upcycling industrial byproducts into material with specific structure and properties result in additional commercial and industrial applications and value.
Catheter comprising altered geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
A61M 27/00 - Drainage appliances for wounds, or the like
B33Y 80/00 - Products made by additive manufacturing
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Systems and alloying methods for forming metals are described. Waste materials from various industrial processes and botched master alloy production heats result in numerous byproducts that can form constituent components for the formation of bulk alloys with higher value and more diverse applications. Reusing and upcycling industrial byproducts into material with specific structure and properties result in additional commercial and industrial applications and value.
C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
B22F 9/08 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes starting from liquid material by casting, e.g. through sieves or in water, by atomising or spraying
92.
A WEARABLE APTAMER NANOBIOSENSOR FOR NON-INVASIVE FEMALE HORMONE MONITORING
Some implementations of the disclosure relate to a wearable biosensor device including: a microfluidic module configured to collect a sweat sample from skin of a user, route the sweat sample to a sensing reservoir that is filled with the sweat sample, and route additional sweat away from the sensing reservoir when the sensing reservoir is filled; and a sensor assembly configured to quantify the biomarker of the sweat sample in the sensing reservoir to determine a concentration of the biomarker present in the sweat sample. The sensor assembly includes a biorecognition interface having a surface functionalized with an aptamer that binds to the biomarker.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
93.
SYSTEMS AND METHODS FOR DYNAMIC-BACKBONE PROTEIN-LIGAND STRUCTURE PREDICTION WITH MULTISCALE GENERATIVE DIFFUSION MODELS
In some aspects, the present disclosure provides a method for generating a geometrical structure of a binding complex formed between a protein and a ligand. In some embodiments, the method comprises sampling an initial geometrical structure of the binding complex from a geometry prior. In some embodiments, the method comprises denoising, using a machine-learned stochastic differential equation (SDE), the initial geometrical structure to generate the geometrical structure of the binding complex.
Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing.
F28D 15/02 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes
F28D 15/04 - Heat-exchange apparatus with the intermediate heat-transfer medium in closed tubes passing into or through the conduit walls in which the medium condenses and evaporates, e.g. heat-pipes with tubes having a capillary structure
Interferometric speckle visibility spectroscopy methods, systems, and non-transitory computer readable media for recovering sample speckle field data or a speckle field pattern from an off-axis interferogram recorded by one or more sensors over an exposure time and determining sample dynamics of a sample being analyzed from speckle statistics of the speckle field data or the speckle field pattern.
Disclosed are plasmonic sensors, and systems and methods related to plasmonic sensors. The plasmonic sensors include polarization-maintaining optical fibers to avoid cross-talk between wanted and unwanted components within a plasmonic response signal. The plasmonic sensors, systems, and methods can involve detecting components within a signal outside of the polarization direction of an excitation signal for reducing issues found in the signal matching the polarization direction of the excitation signal. The plasmonic sensors, systems, and methods use specific lattice arrangements of plasmonic material nanostructures.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G02B 27/28 - Optical systems or apparatus not provided for by any of the groups , for polarising
The present application relates to hybridization chain reaction (HCR). In particular, the sensitivity of hybridization chain reaction (HCR) signal amplification is combined with two or more fractional-initiator probes and one or more proximity probes able to colocalize a full HCR initiator that will trigger HCR when the targets are in proximity to one another.
The present disclosure describes a cavity accumulating the intensity of the laser beams reflecting within the cavity to build up power while also maintaining a relatively uniform intensity distribution. An apparatus comprising the cavity can be used to build up the power of the electromagnetic radiation for interacting with material, wherein the material does not substantially reflect or absorb the electromagnetic radiation.
The present application relates to hybridization chain reaction (HCR). In particular, the sensitivity of hybridization chain reaction (HCR) signal amplification is combined with two or more fractional-initiator probes and one or more proximity probes able to colocalize a full HCR initiator that will trigger HCR when the targets are in proximity to one another.
