Abstract

Integrated tidal desalination system that harnesses tidal power to produce drinkable water through a mechanically linked or direct drive integrated tidal turbine (ITT) and centrifugal reverse osmosis (CRO) system. The ITT-CRO system eliminates conversion losses in the power take-off unit by eliminating the need for electrical energy conversion. The ITT-CRO system is modelled, and the model used for control, and predictive maintenance.

IPC Classes  ?

• B01D 61/10 - AccessoriesAuxiliary operations
• B01D 61/08 - Apparatus therefor
• B01D 63/16 - Rotary, reciprocated or vibrated modules
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 103/08 - Seawater, e.g. for desalination

Abstract

A microporous crystalline lattice composition formed by a plurality of chemical subunits bound by a series of cross-linked covalent tetraphenoxyb orate linkages and weak ion-dipole interactions forming an ionic covalent organic framework (ICOF) having a plurality of tunable iso-surface channels.

IPC Classes  ?

• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties

Abstract

Disclosed herein are pharmaceutical agents that inhibit or suppress OTUD4 and CD73 binding interactions; thus, useful in the context of managing diseases and conditions associated with OTUD4 and CD73 binding interactions, such as cancer treatments. In certain embodiments, this disclosure relates to method of treating cancer comprising administering an effective amount of a pharmaceutical agent that suppress OTUD4 and CD73 binding interactions. In certain embodiments, the therapeutic agent is a small molecule, antibody, or other specific binding agent.

IPC Classes  ?

• A61K 31/4196 - 1,2,4-Triazoles
• A61P 35/00 - Antineoplastic agents

Abstract

e.ge.g., AAV vectors) encoding the tPA variants. Also provided are pharmaceutical compositions comprising the tPA variants and vectors, and therapeutic uses of the pharmaceutical compositions to treat intraocular pressure (IOP)-associated conditions, such as glaucoma.

IPC Classes  ?

• A61K 38/49 - UrokinaseTissue plasminogen activator
• A61P 27/02 - Ophthalmic agents
• C12N 15/864 - Parvoviral vectors
• C12N 9/72 - Urokinase

Abstract

Provided herein are methods and uses of compounds for direct scavenging of and/or direct reduction of the concentration of one or more reactive oxygen species (ROS), and for therapy of associated diseases and disorders. Also provided herein are methods and uses of the compounds for preventing loss of, maintaining, or restoring mitochondrial function, and for therapy of associated diseases and disorders. Also provided herein are methods and uses of the compounds for treating or preventing signs of aging.

IPC Classes  ?

• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61P 39/06 - Free radical scavengers or antioxidants

Abstract

The invention provides a compound having the structure: The invention provides a compound having the structure: wherein R1 and R2 are each independently H, halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, -alkyl-NR14R15, -alkyl-OR14, C1-10 alkyl, C2-10 alkenyl, or C2-10 alkynyl; or wherein R1 and R2 together formed into a cycloalkyl or cycloheteroalkyl; wherein R3 and R7 are each independently H, halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, -alkyl-NR14R15, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; wherein R4 and R6 are each independently H, —NO2, —SR14, —SO2R14, —OR14, —CO2R14, -alkyl-NR14R15, -alkyl-OR14, C2-10 alkenyl or C2-10 alkynyl; wherein R5 is —NO2, —NHR14, —NR14R15, —SR14, —SO2R14, —(C═O)—NH—R14, —CO2R14, -alkyl-NR14R15, -alkyl- OR14, C2-10 alkenyl, C2-10 alkynyl, —(C0-10 alkyl)-heterocyclyl, The invention provides a compound having the structure: wherein R1 and R2 are each independently H, halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, -alkyl-NR14R15, -alkyl-OR14, C1-10 alkyl, C2-10 alkenyl, or C2-10 alkynyl; or wherein R1 and R2 together formed into a cycloalkyl or cycloheteroalkyl; wherein R3 and R7 are each independently H, halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, -alkyl-NR14R15, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; wherein R4 and R6 are each independently H, —NO2, —SR14, —SO2R14, —OR14, —CO2R14, -alkyl-NR14R15, -alkyl-OR14, C2-10 alkenyl or C2-10 alkynyl; wherein R5 is —NO2, —NHR14, —NR14R15, —SR14, —SO2R14, —(C═O)—NH—R14, —CO2R14, -alkyl-NR14R15, -alkyl- OR14, C2-10 alkenyl, C2-10 alkynyl, —(C0-10 alkyl)-heterocyclyl, wherein R8, R9, R10, and R11 are each independently N or CH; wherein R12 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, cycloalkyl, cycloheteroalky, or heterocyclyl; wherein R13 is halogen, —NO2, —CN, —NHR14, —NR14R15, —SR14, —SO2R14, —OR14, —CO2R14, —CF3, —NR14R15, —OR14, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, cycloalkyl, cycloheteroalky, or heterocyclyl; wherein R14 is H, C2-10 alkenyl, C2-10 alkynyl, —C═O-alkyl-aryl, or alkyl-aryl; wherein R15 is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, —C═O-alkyl-aryl, or alkyl-aryl; wherein X is CH2 or NH; wherein R3 and R5 are not both halogen, R5 and R7 are not both halogen; wherein when R3 or R7 is halogen, R4 and R6 are not alkyl; wherein when R5 is —(C0-10 alkyl)-heterocyclyl, the heterocyclyl is not tetrahydropyranyl; wherein when R3 or R7 is halogen, R4 and R6 are not —OR14; wherein when R3 is alkyl or H, R6 is not —NHR14 and —NR14R15; wherein when R7 is alkyl or H, R4 is not —NHR14 and —NR14R15.

IPC Classes  ?

• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• C07D 213/64 - One oxygen atom attached in position 2 or 6
• C07D 249/06 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
• C07D 401/10 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 413/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Provided herein are compounds and compositions for the treatment of diseases or conditions such as cancer. Also provided herein methods of treating diseases and conditions and methods of making compounds and compositions.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61K 51/08 - Peptides, e.g. proteins
• A61P 35/00 - Antineoplastic agents

Abstract

In some aspects, the present disclosure provides a lithium metal battery having a negative electrode that comprises a substantially pure lithium metal and a positive electrode that comprises the epsilon polymorph of vanadyl phosphate (ε-VOPO4). The lithium metal can have less than five ppm of non-metallic elements by mass. The ε-VOPO4 can be made from solvothermally synthesized H2VOPO4, and be optimized to reversibly intercalate two Li-ions to reach full theoretical capacity with a coulombic efficiency of 98%. This material can adopt a stable 3D tunnel structure and can extract two Li-ions per vanadium ion, giving a theoretical capacity of 305 mAh/g, with an upper charge/discharge plateau at around 4.0 V, and one lower at around 2.5 V. The ε-VOPO4 particles may be modified with niobium (Nb) to improve the cycling stability.

IPC Classes  ?

• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/04 - Processes of manufacture in general
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/052 - Li-accumulators

Abstract

Quantum network devices, systems, and methods are provided to enable long-distance transmission of quantum bits (qubits) for applications such as Quantum Key Distribution (QKD), entanglement distribution, and other quantum communication applications. Such systems and methods provide for separately storing first, second, third, and fourth photons, wherein the first and second photons and the third and fourth photons are respective first and second entangled photon pairs, triggering a synchronized retrieval of the stored first, second, third, and fourth photons such that the first photon is propagated to a first node, the second and third photons are propagated to a second node, and the fourth photon is propagated to a third node, and creating a new entangled pair comprising the first and fourth photons at the first and third nodes to transmit quantum information.

IPC Classes  ?

• H04L 9/08 - Key distribution
• G01B 9/02017 - Interferometers characterised by the beam path configuration with multiple interactions between the target object and light beams, e.g. beam reflections occurring from different locations
• H04B 10/70 - Photonic quantum communication

Abstract

The present invention provides a compound having the structure:

IPC Classes  ?

• C07J 43/00 - Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
• C07J 3/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by one carbon atom
• A61K 31/567 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
• A61K 31/06 - Phenols the aromatic ring being substituted by nitro groups

Abstract

Provided are compositions and methods for reducing off-target toxicity of antibody-drug conjugates (ADCs). The compositions comprise an ADC, and an agent targeted to the drug (payload) that is delivered by or derived from the ADC. The ADC and the agent targeted to the payload may be delivered together or separately in the treatment of various conditions (such as tumors) by ADCs. Examples of agents targeted to payload include antibodies, fragments, or modifications thereof.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

Abstract

Methods for treatment of myeloproliferative neoplasms and/or fibrosis associated with cancer are provided. The disclosed methods comprise administering a PIM kinase inhibitor, and optionally a JAK kinase inhibitor or other therapeutic agent, to a mammal in need thereof.

IPC Classes  ?

• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

A surgical system is provided. The surgical system includes a camera operable to capture images and/or video. A projector is operable to project light, and a controller is communicatively coupled with the camera and the projector. The controller is operable to track movement of bone in real-time during surgery based on the images and/or video captured by the camera, and control the projector to project the light including a cutting line on the bone to indicate a cutting plane for cutting the bone during surgery.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 17/90 - Guides therefor
• A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
• A61B 90/96 - Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text using barcodes

Abstract

Polymeric venous valve systems having a supportive frame embedded in a polymeric sleeve and a plurality of polymeric leaflets forming a continuum with the polymeric sleeve are described herein. Methods of making and using such polymeric venous valve systems are also described. The polymeric venous valve systems are well-suited for use in low pressure and low shear venous environments.

IPC Classes  ?

• A61F 2/24 - Heart valves
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

A point-of-care ultrasonography (POCUS) training system, method, terminal which may be used in a mobile environment such as a moving vehicle. The system is configured to compensate for the moving of the moving vehicle when determining an orientation of a probe with respect to a target. After the compensated orientation of the probe is determined, the system may select and display an ultrasound image from among a plurality of images. The selected image corresponds to the determined orientation of the probe and a position of the probe with respect to the target, which is based on a pressure sensor system using a flexible pressure map positioned on the target, where a distal tip of the probe is pressed on the target via the flexible pressure map.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 9/00 - Simulators for teaching or training purposes
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• G01N 29/26 - Arrangements for orientation or scanning

Abstract

Post-copy is one of the two key techniques (besides pre-copy) for live migration of virtual machines in data centers. Post-copy provides deterministic total migration time and low downtime for write-intensive VMs. However, if post-copy migration fails for any reason, the migrating VM is lost because the VM's latest consistent state is split between the source and destination nodes during migration. PostCopyFT provides a new approach to recover a VM after a destination or network failure during post-copy live migration using an efficient reverse incremental checkpointing mechanism. PostCopyFT was implemented and evaluated in the KVM/QEMU platform. Experimental results show that the total migration time of post-copy remains unchanged while maintaining low failover time, downtime, and application performance overhead.

IPC Classes  ?

• G06F 11/14 - Error detection or correction of the data by redundancy in operation, e.g. by using different operation sequences leading to the same result
• G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines
• G06F 11/07 - Responding to the occurrence of a fault, e.g. fault tolerance
• G06F 11/30 - Monitoring

Abstract

4.42444 particles may be modified with niobium (Nb) to improve the cycling stability.

IPC Classes  ?

• H01M 10/0562 - Solid materials

Abstract

The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.

IPC Classes  ?

• A61N 2/02 - Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• A61N 2/00 - Magnetotherapy
• A61N 5/06 - Radiation therapy using light
• C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

Abstract

A cooling device for electronics created ed by additive manufacturing directly on the surface of an electronic device, the colling device created by processes such as controlled focused energy of laser or electron beam, stereolithography, or fused deposition modeling. The cooling device is especially useful in being placed next to or packaged with high-power electronic chips requiring significant heat dissipation.

IPC Classes  ?

• B22F 7/08 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools with one or more parts not made from powder
• B22F 10/14 - Formation of a green body by jetting of binder onto a bed of metal powder
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• B29L 31/34 - Electrical apparatus, e.g. sparking plugs or parts thereof
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating

Abstract

Provided herein are methods and materials for detecting and/or treating subject (e.g., a human) having cancer. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of two or more classes of biomarkers are detected. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of at least one class of biomarkers and the presence of aneuploidy are detected. In some embodiments, methods described herein provide increased sensitivity and/or specificity in the detection of cancer in a subject (e.g. a human).

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/6858 - Allele-specific amplification
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6869 - Methods for sequencing

Abstract

The invention provides anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopa-thy, as well as a method for promoting muscle regeneration in a subject with a myopathy, the method comprising providing the subject with a therapeutically effective amount of an elastase inhibitor. Further provided is a pharmaceutical composition comprising anelastase inhibitor for use in the promotion of muscle regeneration in the treatment of a myopathy. Elastase inhibitors may have a protective effect on muscle progenitor cells and their regenerative potential, which aids muscle cell regeneration. By protecting regenerative potential of muscle progenitor cells, elastase inhibitors enable or enhance the grown of new or existing muscle fibres.

IPC Classes  ?

• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• A61K 31/26 - Cyanate or isocyanate estersThiocyanate or isothiocyanate esters
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

Abstract

Disclosed herein are antibody-drug-conjugates (ADC) that allow for delivery and release of topoisomerase inhibitors into desired tissues. The disclosed ADCs include an AsnAsn peptide that facilitates the release of an exatecan derivative by legumain. The antibody-drug-conjugates are useful as therapeutic agents for treating various cancers. Pharmaceutical compositions which include the ADCs are also disclosed, as are methods of treating a tumor or abnormal cell proliferation by administering a therapeutically effective amount of an antibody-drug-conjugate disclosed herein under conditions effective to treat a tumor or abnormal cell proliferation.

IPC Classes  ?

• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61K 31/33 - Heterocyclic compounds

Abstract

Provided are binding partners that specifically bind to erythrocyte protein SLC4A1 transporter (Band 3) that is highly expressed on erythrocytes. The binding partners are provided as single-specific, bi- specific or multi-specific agents that have improved half-life and/or are effective at a lower concentration. A second component of a bispecific binding partner can bind to a payload-binding selectivity enhancer (PBSE), such as a drug that has been detached from an anti-body drug conjugate. In non-limiting embodiments the PBSE specifically binds to a drug that was administered to an individual as a component of an ADC.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure provides double-stranded nucleic acid compositions that incorporate uracil, gemcitabine, and methotrexate (MTX). More specifically, the present disclosure reveals that the modifications of double-stranded micro-RNA nucleotide sequences with 5-fluorouracil, gemcitabine and methotrexate (MTX) enhance the therapeutic efficacy of tumor suppression and tumor specificity. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-fluorouracil, gemcitabine and methotrexate (MTX) incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions (e.g., formulations) comprising the modified nucleic acid compositions, and methods for treating cancers, such as pancreatic cancer. This is a platform technology that can be applied to other tumor suppressor miRNAs as well as siRNAs.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 35/00 - Antineoplastic agents

Abstract

Systems, methods, and other embodiments described herein relate to multiple three-dimensional (3D) structures formation from a network of circularly-packed structural elements. In one embodiment, a system includes a circularly-packed network of structural elements that form multiple 3D structures. Diameters of the structural elements define a shape of the 3D structures. The circularly-packed network is adaptable to form 1) a first 3D structure and 2) a second 3D structure with a different shape than the first 3D structure. The system also includes a set of joints that connect adjacent structural elements.

IPC Classes  ?

• E04H 15/20 - Tents or canopies, in general inflatable, e.g. shaped, strengthened or supported by fluid pressure

Abstract

A system and method of scheduling tasks, comprising receiving activity and performance data from registers or storage locations maintained by hardware and an operating system; storing calibration coefficients associated with the activity and performance data; computing an energy dissipation rate based on at least the activity and performance data; and scheduling tasks under the operating system based on the computed energy dissipation rate.

IPC Classes  ?

• G06F 1/3209 - Monitoring remote activity, e.g. over telephone lines or network connections
• A61K 36/185 - Magnoliopsida (dicotyledons)
• B03B 1/00 - Conditioning for facilitating separation by altering physical properties of the matter to be treated
• B03B 5/02 - Washing granular, powdered or lumpy materialsWet separating using shaken, pulsated or stirred beds as the principal means of separation
• B03B 5/58 - Bowl classifiers
• B03B 11/00 - Feed or discharge devices integral with washing or wet-separating equipment
• G05D 23/19 - Control of temperature characterised by the use of electric means
• G06F 1/20 - Cooling means
• G06F 1/3203 - Power management, i.e. event-based initiation of a power-saving mode
• G06F 1/3206 - Monitoring of events, devices or parameters that trigger a change in power modality
• G06F 1/3228 - Monitoring task completion, e.g. by use of idle timers, stop commands or wait commands
• G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines
• G06F 9/48 - Program initiatingProgram switching, e.g. by interrupt
• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]
• G06F 13/40 - Bus structure
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
• G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
• H04L 9/40 - Network security protocols
• H04L 69/329 - Intralayer communication protocols among peer entities or protocol data unit [PDU] definitions in the application layer [OSI layer 7]
• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating

Abstract

Oral compositions and methods of reducing oral malodor are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier; and further comprises essential oil.

IPC Classes  ?

• A61K 8/27 - ZincCompounds thereof
• A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• A61K 8/20 - HalogensCompounds thereof
• A61K 8/22 - PeroxidesOxygenOzone
• A61K 8/34 - Alcohols
• A61K 8/36 - Carboxylic acidsSalts or anhydrides thereof
• A61K 8/368 - Carboxylic acidsSalts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/92 - Oils, fats or waxesDerivatives thereof, e.g. hydrogenation products
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/08 - Solutions
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
• A61K 33/20 - Elemental chlorineInorganic compounds releasing chlorine
• A61K 33/30 - ZincCompounds thereof
• A61K 33/40 - Peroxides
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/02 - Inorganic compounds
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

A method of performing state estimation for a microgrid system includes: obtaining a general quantum state estimation model for swing-bus-contained microgrid systems; establishing a state estimation formulation through quantum language; assigning quantum registers used during a quantum state estimation iteration; generating a quantum-circuit-based state estimation solver for performing quantum phase estimation, controlled rotation, and inverse quantum phase estimation; generating a preconditioned quantum linear solver for an ill-conditioned state estimation iteration; iteratively optimizing voltage and residual vectors while iteratively updating preconditioned errors by the state estimation solver, the optimizing and updating iterations continuing until the linear solver reaches convergence; obtaining a quantum state estimation model for hierarchical-based microgrid systems including droop and/or secondary control modes; establishing an enhanced quantum state estimation framework including the state estimation solver and the linear solver; and generating an enhanced state estimation output for controlling one or more parameters of the microgrid system.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms

Abstract

A field effect transistor includes first section and second sections. The first section includes a drift layer. A first P-well is disposed over the drift layer. A first N-source is disposed over the first P-well. A first channel is disposed in an upper portion of the first P-well. The second section includes an area P-well disposed within the drift layer and formed integral with the first P-well. The area P-well includes sidewalls that extend upwards from the drift layer to form an enclosed structure with an outer perimeter and an inner perimeter. An area N-source surrounds the outer perimeter and is formed integral with the first N-source. An upwardly extending intermediate portion of the drift layer extends upwards though the inner perimeter. A second channel is disposed in an upper portion of the sidewalls and is bounded by the inner perimeter and outer perimeter of the sidewalls.

IPC Classes  ?

• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 21/04 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer
• H01L 29/08 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
• H01L 29/66 - Types of semiconductor device
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate

Abstract

Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid-based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.

IPC Classes  ?

• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
• C12Q 1/6839 - Triple helix formation or other higher order conformations in hybridisation assays
• G01N 27/447 - Systems using electrophoresis
• G01N 30/02 - Column chromatography
• G01N 30/86 - Signal analysis

Abstract

A system for generation and execution of brain circuit simulators includes at least one modular, hierarchical design comprising a plurality of micro-circuits. The system includes a neural control circuit simulator executing a simulation of the at least one design. The system includes a user interface comprising at least one interface element for manipulating output of the neural control circuit simulator. A method includes receiving, by a neural control circuit simulator, an identification of at least one modular, hierarchical design comprising a plurality of micro-circuits, the at least one modular, hierarchical design generated by a first user. The neural control circuit simulator executes a first simulation of the at least one design, using a first data set as simulation input. The neural control circuit simulator receives a second data set and executes a second simulation of the at least one modular, hierarchical design, using the second data set as simulation input.

IPC Classes  ?

• G06N 3/10 - Interfaces, programming languages or software development kits, e.g. for simulating neural networks
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

The present disclosure relates to compounds and use thereof as lithographic compositions such as EUV photoresist films. More particularly, embodiments of the disclosure provide lithography compositions and methods of depositing radiation sensitive films, which can be used for patterning applications with UV light, EUV light or electron-beam radiation to form high resolution patterns with low line width roughness. In embodiments, novel ligands are provided for forming radiation sensitive film compositions.

IPC Classes  ?

• G03F 7/004 - Photosensitive materials
• C07F 7/22 - Tin compounds
• C07F 9/92 - Aromatic compounds
• C07F 11/00 - Compounds containing elements of Groups 6 or 16 of the Periodic Table
• G03F 7/16 - Coating processesApparatus therefor
• H01L 21/027 - Making masks on semiconductor bodies for further photolithographic processing, not provided for in group or

Abstract

There are approximately 35,000 abandoned and unplugged oil and gas wells in New York with no known location. Unplugged wells emit methane, a strong greenhouse gas, which has the potential to significantly contribute to global climate change and act as a pollutant chemical. A long-range UAV equipped with methane sensors, MagPike (atomic magnetometer), and LiDAR sensors successfully detected unmarked well sites using characteristic magnetic signals generated by vertical metal piping preserved in the ground. The optimal flight altitude and transect spacing was determined for detection driven by the total field strength of the Earth's magnetic field and the height of tree canopies determined by LiDAR. Traditional methods of identifying oil and gas wells are costly and less powerful in acquisition of data such as using large magnetometers attached to helicopters.

IPC Classes  ?

• G01C 15/00 - Surveying instruments or accessories not provided for in groups
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use
• B64U 10/13 - Flying platforms
• B64U 101/00 - UAVs specially adapted for particular uses or applications
• B64U 101/30 - UAVs specially adapted for particular uses or applications for imaging, photography or videography
• G01S 19/40 - Correcting position, velocity or attitude
• G05D 1/606 - Compensating for or utilising external environmental conditions, e.g. wind or water currents

Abstract

Systems and methods for decreasing risk-adjusted mortality rates, including identifying patient co-morbidity-related clinical data by preprocessing historical patient data based on rules. Identified co-morbidity-related clinical data is displayed using an interactive user interface for validation, and validated results are stored in an electronic health record (EHR) for the patient. Updated co-morbidity-related clinical is identified by concurrent processing updated patient data based on the rules. The updated co-morbidity-related clinical data is displayed using the interactive user interface for further validation. The EHR is iteratively updated with revised co-morbidity data by the postprocessing upon detection of changes to the EHR.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06F 16/33 - Querying
• G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A system and method for analyzing a sample of earwax for chemical components indicating the presence of an otolaryngological disorder, such as Meniere's Disease. The system includes an analyzer that receives an earwax sample from a person, where the analyzer analyzes the earwax sample and produces diagnostic data. The diagnostic data includes chemical component data for the earwax sample and there is a computer device in communication with analyzer, and the computer device receives the diagnostic data from the analyzer and detects a predetermined combination of chemical components in the earwax sample which will indicate the presence of an otolaryngological disorder.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 30/02 - Column chromatography
• G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
• G01N 33/483 - Physical analysis of biological material
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The invention provides adeno-associated virus (AAV) replication (Rep) sequences. In one embodiment, the invention provides nucleotide sequences encoding a chimeric protein, wherein the encoded chimeric protein contains a wild type AAV Rep inhibitory amino acid sequence, and wherein the nucleotide sequences contain a scrambled and/or deoptimized polynucleotide sequence encoding the wild type AAV Rep inhibitory amino acid sequence. The invention provides vectors, cells, and viruses containing the invention's sequences. Also provided are methods for detecting portions of the AAV Rep inhibitory amino acid sequence, which reduce replication and/or infection and/or productive infection by viruses. The invention's compositions and methods are useful for site-specific integration and/or expression of heterologous sequences by recombinant adeno-associated virus (rAAV) vectors and by rAAV virus particles, such as hybrid viruses (e.g., Ad-AAV) comprising such vectors. The invention's compositions and methods find application in, for example, gene therapy and/or vaccines.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• A61K 38/46 - Hydrolases (3)
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
• C12N 9/22 - Ribonucleases
• C12N 15/86 - Viral vectors
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Abstract

A system for determining atomic structure and dynamics of salt under certain temperatures as a function of temperature above and below salt melting, contains a quartz tube containing a first end and a second end, and a graphite rod that is located within the quartz tube. The graphite rod contains a hollow center that extends from a top portion of the rod to a location prior to a bottom of the rod, wherein the bottom portion of the rod is enclosed. A sample of salt is located within the hollow center of the graphite rod. A filling material having the characteristics of not reacting to the graphite rod and not changing state with heating of the salt to a melting point of the salt, and wherein the filling material is positioned beneath the graphite rod between the second end of the quartz tube and the bottom of the graphite rod.

IPC Classes  ?

• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 1/44 - Sample treatment involving radiation, e.g. heat

Abstract

A solar vapor generation system includes a substrate configured to wick solution from a reservoir. The substrate includes a first planar sheet having a first end, and a second planar sheet having a first end. The first end of the first planar sheet is connected to the first end of the second planar sheet at an angle of less than 180.0 degrees. In some embodiments, the angle is less than 90.0 degrees. At least a portion of the first planar sheet is configured to be in contact with the solution. The system includes a support, configured to support the substrate at a position near a surface of the solution.

IPC Classes  ?

• F22B 1/00 - Methods of steam generation characterised by form of heating method
• B01D 1/00 - Evaporating
• B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
• C02F 1/04 - Treatment of water, waste water, or sewage by heating by distillation or evaporation
• C02F 1/14 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using solar energy
• C02F 103/08 - Seawater, e.g. for desalination
• F24S 20/30 - Solar heat collectors for heating objects, e.g. solar cookers or solar furnaces

Abstract

A method of treating contaminated water, such as wastewater, with carboxylated cellulose to remove ammonium and nitrogen-containing impurities is claimed. Carboxylated cellulose extracted by nitro-oxidation has negatively-charged functionality and forms an aggregate when exposed to positively-charged impurities in contaminated water. The aggregate, nitrogen-containing impurities, and by-products from the nitro-oxidation process can be isolated to provide a fertilizer or fertilizer component.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• C02F 101/16 - Nitrogen compounds, e.g. ammonia
• C05F 7/00 - Fertilisers from waste water, sewage sludge, sea slime, ooze or similar masses

Abstract

A system and method for tuning a high-resistivity layer of TaN deposited by atomic layer deposition (ALD) over a superconducting metal underlayer that has undergone one of a set of treatments. The underlayer can be chosen or modified in such a way to yield an ALD TaN thin film with predictably high- or low-resistivity. A low-resistivity layer of ALD TaN is deposited on exposed metal layers, whether they are superconducting metals or non-superconducting metals, while a high-resistivity layer of ALD TaN is deposited on exposed dielectrics, as well as modified surfaces of exposed metals. This modification may be achieved through the use of a physical vapor deposited (PVD) metal nitride intervening layer, such as PVD TaN and PVD NbN, deposited between the high-resistivity layer and the metal layer.

Abstract

A microstructure that detects the acoustic velocity of a fluid by employing microfabricated thin sensing elements that are primarily driven by viscous forces due to the fluctuating motion of a fluid, such as air in a sound field. The microstructures can be fabricated in an array to create a diaphragmless microphone. The microstructure and its components can be fabricated on a single or multilayer substrate with the use of masks.

IPC Classes  ?

• H04R 19/04 - Microphones
• H04R 31/00 - Apparatus or processes specially adapted for the manufacture of transducers or diaphragms therefor

Abstract

A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.

IPC Classes  ?

• H10K 30/10 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising heterojunctions between organic semiconductors and inorganic semiconductors
• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• H01L 31/0256 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by the material
• H10K 39/32 - Organic image sensors
• H10K 39/36 - Devices specially adapted for detecting X-ray radiation

Abstract

Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/155 - Paramyxoviridae, e.g. parainfluenza virus
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses

Abstract

Disclosed herein are novel well-defined telodendrimer nanodrugs featured with multiple negative charges and hydrophobic groups to mimic endotoxin for toll-like receptor binding, thus to modulate immune response. The next generation TD nanodrugs can actively fine-tuned inflammation control against a broad spectrum of immune stimuli via pleiotropic mechanisms; and some TD nanodrugs can stimulate immune response by activating TLR for potential cancer immunotherapy; as well as TD nanodrugs that can form nanocarrier for the delivery of vital antibiotics, anticancer drugs or other therapeutics for disease treatments with simultaneous immune modulation effects.

Abstract

Amphotericin B (AmB) is the gold standard for treatment of life-threatening systemic fungal infections. To develop cost-effective AmB formulations with reduced toxicity, embodiments disclosed introduce controlled number of phenylboronic acid (PBA) moieties into telodendrimer (TD) nanoplatform for optimizing AmB conjugation via reversible boronate ester strategy. This multivalent flexible boronate TD nanoplatform can also be applied in developing prodrugs for different cis-diol containing or α- or β- hydroxyl ketone-containing drug molecules.

IPC Classes  ?

• A61K 31/69 - Boron compounds

Abstract

A tissue sample sectioning device including a supporting matrix having a top surface, configured to accept a tissue sample thereon, a micro-scaffold comprising a top, a bottom, and a plurality of micro-wells, wherein each micro-well is defined by at least one or more walls that extend between the top and the bottom of the micro-scaffold, and each of the one or more walls has a cutting edge at the bottom of the micro-scaffold, and a press configured to apply a force onto the micro-scaffold, such that when a force is applied, the cutting edge cuts the tissue sample, and the tissue sample is sectioned into the plurality of micro-wells. The disclosure also provides a method of sectioning a tissue sample using the supporting matrix and the micro- scaffold by applying a force.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A device that fits over the end of a drill bit to enable the user to center the bit over a predetermined location, usually made with a center punch drill rig. The device slips over the end of the drill bit and has a pointed end for locational purposes. The device can be inexpensively manufactured in plastic, aluminum, or steel as needed for durability and cost effectiveness.

IPC Classes  ?

• B23B 51/12 - Adapters for drills or chucksTapered sleeves
• B23B 49/00 - Measuring or gauging equipment on boring machines for positioning or guiding the drillDevices for indicating failure of drills during boringCentring devices for holes to be bored

Abstract

A secure processor, comprising a logic execution unit configured to process data based on instructions; a communication interface unit, configured to transfer of the instructions and the data, and metadata tags accompanying respective instructions and data; a metadata processing unit, configured to enforce specific restrictions with respect to at least execution of instructions, access to resources, and manipulation of data, selectively dependent on the received metadata tags; and a control transfer processing unit, configured to validate a branch instruction execution and an entry point instruction of each control transfer, selectively dependent on the respective metadata tags.

IPC Classes  ?

• G06F 21/12 - Protecting executable software
• G06F 9/32 - Address formation of the next instruction, e.g. by incrementing the instruction counter
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead
• G06F 12/10 - Address translation
• G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules

Abstract

Systems and methods for live updating virtualization systems are disclosed. One method may include identifying a container on a first virtual machine of a virtualization system. The container may include at least one process associated with performing a task on a first virtual machine. The method may also include determining a first communication path between the process included in the container on the first virtual machine and a hypervisor of the virtualization system, and migrating the container and the process included in the container to a second virtual machine. The second virtual machine may be distinct from the first virtual machine. Additionally, the method may include determining a second communication path between the process included in the migrated container on the second virtual machine and the hypervisor of the virtualization system.

IPC Classes  ?

• G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines

Abstract

A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: A method of increasing production of one or more lipoxins in a subject in need thereof comprising administering to the subject an amount of a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, so as to thereby increase production of the one or more lipoxins in the subject.

IPC Classes  ?

• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/12 - Ketones
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone

Abstract

Additively manufactured non-metal particle and metal matrix composites are provided. An intermetallic compound interface layer, e.g., metal carbide, is formed between the non-metal particle, e.g., diamond, and the metal matrix, that enhances thermal transfer. One application of this is to form thermal management structures with high thermal conductivity via laser powder bed fusion. A powder material for additively manufacturing a structure, comprising metal particles; and non-metallic particles with thermal conductivities greater than 100 W/m-K and coefficient of thermal expansion less than 10 ppm/degree C., wherein the metal particles are fusible with heat to form a heterogeneous solid structure around the non-metallic particles with an intermetallic compound interface, the heterogeneous solid structure having enhanced thermal conductivity and lower coefficient of thermal expansion with respect to a homogeneous specimen of the fused metal particles alone.

IPC Classes  ?

• B22F 1/12 - Metallic powder containing non-metallic particles
• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

A digital twin which may be used to determine the health of a power converter, a method for using the digital twin and a health monitoring system is provided. The digital twin may comprise a plurality of state equations representing circuit components of the power converter and at least one associated value for each component. Each state equation is capable of representing the circuit components for a defined power converter topology and related variants. The digital twin also has a self-evolving monitoring function. The self-evolving monitoring function has adjustable model parameters, an adjustable threshold and adjustable determination parameters. The adjustable model parameters may include weights for combining determined voltage and determined current, respectively. The adjustable determination parameters may be used to determine sets of values for the components for predicting the voltage and current, respectively. The method/system is able to, in real-time, determine component degradation in the power converter.

IPC Classes  ?

• G01R 31/28 - Testing of electronic circuits, e.g. by signal tracer
• G06F 17/40 - Data acquisition and logging

Abstract

Disclosed herein are antibody-drug-conjugates (ADC) of Formula (A) containing both a toll-like receptor (TER) agonist (immune stimulant) and MMAF or MMAE: (Formula A) The antibody-drug-conjugates are useful as therapeutic agents for treating various cancers. Pharmaceutical compositions which include the ADCs are also disclosed. Also disclosed are methods of treating a tumor or abnormal cell proliferation by administering a therapeutically effective amount of an antibody-drug-conjugate disclosed herein under conditions effective to treat a tumor or abnormal cell proliferation. Also disclosed are methods for stimulating an immune response and/or inducing an anti -tumor immune response in a subject by administering a therapeutically effective amount of an antibody-drug-conjugate disclosed herein.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 31/4188 - 1,3-Diazoles condensed with heterocyclic ring systems, e.g. biotin, sorbinil
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 38/08 - Peptides having 5 to 11 amino acids
• C07D 487/00 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure relates generally to trans-cyclooctene-modified TPD conjugate comprising a targeted protein degrader (TPD) covalently bonded to at least one trans-cyclooctene moiety, optionally via a linker, which conjugates have applications, e.g., in the treatment of cancer, tumor growth, and immunotherapy.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents

Abstract

Provided is provided is a compound of Formula I Provided is provided is a compound of Formula I Provided is provided is a compound of Formula I and a method of forming a tagged 2-thiouridine tRNA by contacting it with a compound of Formula I, wherein the compound may include a label such as a fluorescent label. Also provided is a method of forming a tagged RNA, comprising contacting a prenylated tRNA or an N6-isopentenyladenosine-prenylated RNA with a 4-phenyl-1,2,4-triazoline-3,5-dione activated fluorescence label. Also provided is a method of sequencing a polyribonucleotide comprising a prenyl group.

IPC Classes  ?

• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label

Abstract

The present disclosure relates to IgA antibodies and antigen binding fragments thereof and to cocktails of antibodies and antigen binding fragments that neutralize virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The present disclosure also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61P 31/04 - Antibacterial agents

Abstract

The present disclosure provides methods of using compositions that inhibit SII2-containing inositol 5′-phosphatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.

IPC Classes  ?

• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/568 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone
• A61K 31/5685 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone having an oxo group in position 17, e.g. androsterone
• A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Abstract

Disclosed herein are processes directed to Native Peptide Cyclization (NPC) and chemoselective methods enabling intramolecular and intermolecular peptidyl ligation without the need for premodification of starting peptides. NPC cyclizes unprotected linear peptides through controlled, sequential C- and N-terminal NPC simplifies peptide ligation, easing the labor-intensive nature of peptide synthesis, efficient cyclic peptide preparation and enabling cost-effective macrocycle-based therapeutics.

IPC Classes  ?

• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 7/64 - Cyclic peptides containing only normal peptide links

Abstract

The present disclosure provides a microorganism and expression cassette useful for biologically producing PHA ho-mopolymers and/or PHA copolymers, including PHB-co-MCL copolymers of controllable or predetermined composition. In embodiments, the present disclosure provides a nucleic acid construct suitable for use in a microorganism and/or expression cassette including a nucleic acid construct including: one or more genes comprising a phaJ4 gene, a phaA gene, a phaB gene, a phaC1 gene, or combinations thereof; a cDNA that encodes one or more proteins comprising an enoyl-CoA hydratase 2, a β-ketothiolase, an acetoacetyl-CoA reductase, a type II poly hydroxyalkanoate synthase, or combinations thereof; or one or more nucleic acid sequences that encode one or more proteins including an enoyl-CoA hydratase 2, a β-ketothiolase, an acetoacetyl-CoA reductase, a type II poly hydroxyalkanoate synthase, or combinations thereof.

IPC Classes  ?

• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 1/20 - BacteriaCulture media therefor
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/10 - Transferases (2.)
• C12N 9/14 - Hydrolases (3.)
• C12P 7/625 - Polyesters of hydroxy carboxylic acids

Abstract

The present disclosure provides methods for treating biowaste and similar waste sources with nitric acid. Where the waste source includes plant-based fibrous materials, animal and food waste, the present methods provide for the extraction and use of nanostructured cellulose (nanocellulose) with an anionic surface charge for adsorption of cationic contaminants such as ammonium, and selective environmentally friendly methods for the functionalization of cellulosic biomass.

IPC Classes  ?

• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
• B09B 3/40 - Destroying solid waste or transforming solid waste into something useful or harmless involving thermal treatment, e.g. evaporation
• C05F 17/50 - Treatments combining two or more different biological or biochemical treatments, e.g. anaerobic and aerobic treatment or vermicomposting and aerobic treatment
• C05F 9/00 - Fertilisers from household or town refuse

Abstract

A deep-learning artificial intelligence (AI) framework that applies neuromorphic analysis to complex clinical MRI DICOM datasets to enable typing of brain tumors that are glioblastomas or of metastatic origin with high accuracy. The data processing is optimized to address MRI modality class imbalance, remove lack of comparability, and aid generalizability to create a computationally light, portable, highly accurate and reliable diagnosis platform. The present AI capabilities to continue learning from complex and diverse clinical MRI datasets brings MRI robustness in biomedical neurosurgical treatment pre-planning, with applications in other brain pathologies and expanded use in artificial generalizable intelligence.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06N 3/08 - Learning methods
• G06N 5/04 - Inference or reasoning models
• G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
• G06N 20/00 - Machine learning

Abstract

A system and method for producing a flattened and smoothed metallic wafer using a top pressure tool plate and a bottom pressure tool plate with a first pressure application device in physical contact with the top pressure tool plate and a second pressure application device in physical contact with the bottom pressure tool plate. A first semiconductor wafer in is selective contact with the top pressure tool plate and a second semiconductor wafer is in selective contact with the bottom pressure tool plate, with a metallic wafer held between the first semiconductor wafer and second semiconductor wafer. The first and second semiconductor wafers can be Si wafers. A predetermined amount of pressure is applied for a predetermined duration from the top pressure tool plate and bottom pressure tool plate with the first pressure application device and second pressure application device to flatten and smooth the metallic wafer.

IPC Classes  ?

• B21D 39/03 - Application of procedures in order to connect objects or parts, e.g. coating with sheet metal otherwise than by platingTube expanders of sheet metal otherwise than by folding

Abstract

The embodiments disclosed herein are directed to identifying novel mechanisms of transcription in prostate cancer by a unique DNA binding mechanism involving actin cytoskeleton regulatory protein ABI1. Further embodiments disclosed herein are directed to ABI1-DNA binding activities that predict survival of prostate cancer patients. Moreover, the embodiments disclosed herein are directed to ABI1-AR reciprocal regulation that has far reaching implications for tumor plasticity and androgen-sensitive pathogenesis.

IPC Classes  ?

• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

A method for enhanced phytoremediation by changing bioavailability of per- and polyfluoroalkyl substances (PFAS) to plants in biosolids amended soil through stabilization or mobilization. A mobilizing reagent can be added at a predetermined dose, to amend the soil around a root system of one or more plants, and the amended soil can also be supplemented with a stabilizing reagent at a predetermined dose to change the bioavailability of (PFAS) to one or more plants in the amended soil. Through adjustment of the mobilizing reagent and stabilizing reagent, the uptake of PFAS by the one or more plants can be selectively increased or decreased.

IPC Classes  ?

• C05G 3/80 - Soil conditioners
• C05D 9/00 - Other inorganic fertilisers
• C05G 3/50 - SurfactantsEmulsifiers

Abstract

A method for forming a ceramic aerogel includes contacting a ceramic precursor, an additive, an anionic surfactant, a cationic surfactant, and a catalyst to form a mixture. The catalyst may include an acid or a base. The method further includes heating the mixture to form a precursor gel, mixing fibers with the precursor gel, and drying the resultant fiber containing precursor gel.

IPC Classes  ?

• C04B 35/14 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silica
• C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof
• C04B 38/02 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof by adding chemical blowing agents

Abstract

Provided are compounds having the following structure: (I) or (II) The compounds may be used to sequester one or more hydrogen-bond acceptors and/or ions. Also provided are methods for making the compounds and methods for using the compounds for treating individuals diagnosed with or suspected of having an extracellular and/or intracellular anion imbalances and/or cystic fibrosis.

IPC Classes  ?

• C07D 259/00 - Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
• C07C 237/28 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
• C07C 237/42 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
• C07D 257/10 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
• C07D 209/02 - Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
• C07D 209/56 - Ring systems containing three or more rings
• C07D 285/15 - Six-membered rings

Abstract

The present disclosure is directed to shear-thinning and stabilizing hydrogels, especially for use in drug delivery, therapy, and 3D printing. Embodiments provide an injectable hydrogel, including: a water-soluble polymer including a first functional group; a host molecule including a second functional group, wherein the second functional group is characterized as complementary to the first functional group; and a guest-terminated star polymer, wherein the guest-terminated star polymer comprises a core unit, a plurality of arms extending from the core unit, and a guest molecule disposed at a terminal end of each of the plurality of arms, and wherein the host molecule and the guest-terminated star polymer are linked by one or more bonds that break under mechanical stress and reform after removal of the mechanical stress.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 38/18 - Growth factorsGrowth regulators
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

This invention provides a compound having the structure This invention provides a compound having the structure This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.

IPC Classes  ?

• C07C 69/738 - Esters of keto-carboxylic acids
• C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
• C07C 225/22 - Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• C07C 235/80 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
• C07C 237/20 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
• C07D 213/50 - Ketonic radicals
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Abstract

Provided is a method for determining if a protein will produce an immunogenic response. The immunogenic response may be correlated by the migration of dendritic cells in the presence of the protein. The method may be used as a screening tool to assess immunogenicity risk for proteins that could be administered subcutaneously.

IPC Classes  ?

• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A method and system for separating hydrogen and methane from a mixture of same, e.g. natural gas, comprising an activated mixed metal hydride and conditions effective, including in one practice select temperatures, pressures, and flow rates whereby unexpected levels of hydrogen absorption occur allowing the methane to be separately recovered for use or storage; the absorbed hydrogen can be used or stored for long durations without degradation. The method can be repeatedly cycled using the same mixed metal hydride solid absorbent to create efficiency.

Abstract

Nanoparticles with a bimetallic silver-copper (AgCu) alloy composition with ambient (room temperature) sintering properties. The bimetallic alloy is formulated with nanoparticles which are contained in a stable nanoink or nanopaste. The nanoink or nanopaste can be printed on paper and other substrates and be sintered under room temperatures. A method of creating the AgCu composition is also provided.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
• B22F 1/0545 - Dispersions or suspensions of nanosized particles
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C09D 11/033 - Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment

Abstract

A device and process for fabricating alginate hydrogel microstrands, and product produced thereby, that are advantageously used for stromal cell encapsulation and maintenance. The device has first reservoir including a cell-alginate solution therein that selectively intakes and expels the cell-alginate solution therefrom, and a second reservoir in fluid connection with the first reservoir, the second reservoir containing a cross-linker solution and selectively intakes the cell-alginate solution from the first reservoir and expels the combined cell-alginate solution and cross-linker solution therefrom. The second reservoir selectively expels the combined cell-alginate solution and cross-linker solution as cell-laden hydrogel microstrands. The reservoirs of the device can be interconnected syringes.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic

Abstract

A system and method of laying out an integrated circuit, comprising defining a netlist of circuit elements comprising a plurality of macro blocks and standard cells of the integrated circuit, each macro block and standard cell having a respective area requirement; obtaining and storing a hierarchical abstract relative positioning (SHARP) of the circuit elements by at least one of repeatedly partitioning the netlist using bisection, and inducing cut lines into an abstract placement generated by an analytic placement tool; defining a plurality of arrangements of the macro blocks and standard cells within a respective region utilizing the SHARP; legalizing the plurality of arrangements to form legalized regions, each legalized region meeting the area requirements of the circuit elements within each respective region; and merging the legalized regions to generate a set of potential placements.

IPC Classes  ?

• G06F 30/392 - Floor-planning or layout, e.g. partitioning or placement

Abstract

System and method to improve the linearity of vector matrix multipliers (VMMs) by including (1) delta-sigma modulators that convert the input and output activations into binary pulse trains, (2) charge-domain computation in each SRAM cell that removes the nonlinear dependency on bitline voltage of the result of the multiplication and allows rail-to-rail output swing, and (3) a CMOS switch that transmits input activation to the capacitor in the SRAM cell, which improves linearity by suppressing the switch threshold voltage dependence on input activation voltage.

IPC Classes  ?

• G11C 11/419 - Read-write [R-W] circuits
• H03M 3/00 - Conversion of analogue values to or from differential modulation

Abstract

A diabetic foot examination device that monitors the progress of diabetic ulcers in a human foot based upon using, at least, visible light illumination. The device includes a body with a diagnostic pane located on an upper structure of the body and held at an angled relation to the base. The diagnostic pane is at least partially transparent to visible light and supports at least one foot placed thereupon. There is a camera affixed to the body that, at least, detects visible light and is positioned to view a foot placed against the diagnostic pane to generate diagnostic data from the detected illumination. An illumination source is affixed to the body to project light at the diagnostic pane. There is also a computer platform in communication with the camera and illumination source to control illumination, receive diagnostic data from the camera, and then create a diabetic ulcer diagnostic data.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A system and method for testing the durability of a cylindrical asphalt sample that is held within an apparatus and a load cell is moved by an actuator to apply a range of predetermined force against the cylindrical asphalt sample. The actuator is controlled by a computer device, further senses the resistance of the cylindrical asphalt sample to the predetermined force and communicates the sensed resistance data to the computer device. The computer device uses a Timoshenko Beam Theory (TBT) Model or a Viscoelastic Continuum Damage (VECD) Model to determine the deflection in the cylindrical asphalt sample to determine a durability measurement of the asphalt based upon the determined deflection.

IPC Classes  ?

• G01N 3/20 - Investigating strength properties of solid materials by application of mechanical stress by applying steady bending forces
• G01N 3/06 - Special adaptations of indicating or recording means
• G01N 33/42 - Road-making materials

Abstract

Nanohybrid composites, methods of making nanohybrid composites, and uses of nanohybrid composites. A nanohybrid composite may be a binary nanohybrid composite comprising MXene and dual-phase MoS2. A nanohybrid composite may be a ternary nanohybrid composite comprising MXene, dual-phase MoS2, and a plurality of carbon nanotubes. A nanohybrid composite may be made by a method comprising contacting a liquid or liquid(s), a MXene or MXenes, a sulfur precursor or sulfur precursors, a molybdenum precursor or molybdenum precursors, optionally, an ammonium precursor or ammonium precursors, and, optionally, carbon nanotubes to form a reaction mixture; heating the reaction mixture, where the nanohybrid composite is formed. Anodes may comprise one or more nanohybrid composite(s). Devices, such as, for example, batteries or the like, may comprise one or more anode(s) comprising one or more nanohybrid composite(s) and/or one or more nanohybrid composite(s).

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• H01G 11/36 - Nanostructures, e.g. nanofibres, nanotubes or fullerenes
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 4/90 - Selection of catalytic material

Abstract

The present invention provides a compound having the structure: The present invention provides a compound having the structure: wherein R3, R4, R5, R6, and R7 are each independently, H, halogen, CN, —CF3, —OCF3, —NO2, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR13, —COR13, —CH2OR13, —SH, —SR13, —SO2R13, —NH2, —NHR13, —NR14R15, —NHCOR12, or —CONR14R15; R9, R10, R11, and R12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —COR13, —SH, —SR13, —SO2R13, —NH2, —NHR13, —NR14R15, —NHCOR12, or —CONR14R15; wherein each occurrence of R13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein when R14 is methyl, R15 is not methyl; wherein at least one of R9, R10, R11, and R12 is not H; wherein at least one of R3, R4, R5, R6, and R7 is not H.

IPC Classes  ?

• C07C 251/86 - Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/396 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
• A61P 31/10 - Antimycotics
• C07D 229/02 - Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms containing three-membered rings

Abstract

The epsilon polymorph of vanadyl phosphate, ε-VOPO4, made from the solvothermally synthesized H2VOPO4, is a high-density cathode material for lithium-ion batteries optimized to reversibly intercalate two Li-ions to reach the full theoretical capacity at least 50 cycles with a coulombic efficiency of 98%. This material adopts a stable 3D tunnel structure and can extract two Li-ions per vanadium ion, giving a theoretical capacity of 305 mAh/g, with an upper charge/discharge plateau at around 4.0 V, and one lower at around 2.5 V.

IPC Classes  ?

• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• C01B 25/37 - Phosphates of heavy metals
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/136 - Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 4/1397 - Processes of manufacture of electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

A liquid cooled cold plate for removing heat from an electronic apparatus. The liquid cooled cold plate includes a support base and one or more regions of high heat flux cooling structures in thermal contact with the support base. Liquid flow channels for directing a cooling liquid to flow through the cooling structures determine the flow rate and pressure of the cooling liquid. The cooling structures may include cooling posts, cooling rods, cooling cones, cooling fins and/or a complex arrangement of interconnected cooling structures such as interconnected cooling rods. These structures may be of uniform size or non-uniform size. One or more of the liquid flow channels may include a liquid throttling zone. This liquid throttling zone can be oriented horizontally or vertically relative to the support base of the liquid cooled cold plate. 3D printing as well as other manufacturing techniques may be used to produce the cold plate.

IPC Classes  ?

• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating

Abstract

A solar vapor generator system and method are provided. In some embodiments, the system has near perfect energy conversion efficiency in the process of solar vapor generation below room temperature. Remarkably, when the operation temperature of the system is below that of the surroundings, the total vapor generation will be higher than the upper limit that can be produced by the input solar energy.

IPC Classes  ?

• C02F 1/14 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using solar energy
• B01D 1/00 - Evaporating
• B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
• C02F 103/00 - Nature of the water, waste water, sewage or sludge to be treated
• C02F 103/08 - Seawater, e.g. for desalination

Abstract

Provided herein, inter alia, are methods and compositions for assembling oligonucleotide fragments in vivo. The methods bypass inefficient cloning methods and the requirement for expensive enzymes. The methods may further be used to assemble long fragments of DNA. The methods may be used to generate variant libraries and combinatorial libraries and may be used to trace biological processes. Also provided herein, inter alia, are methods for in vivo DNA barcoding of oligonucleotide sequences. Methods provided herein are contemplated to produce unique barcode-oligonucleotide fusion sequences for identifying and isolating the oligonucleotide sequences, e.g., from a mixture. Accordingly, also provided are methods of identifying an oligonucleotide from a mixture of oligonucleotides.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms

Abstract

BC RNA decoys and methods of use thereof are disclosed which inhibit anti-BC antibodies from causing intraneuronal mislocalization of BC RNAs, thereby treating lupus.

IPC Classes  ?

• C12N 15/117 - Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs

Abstract

A biomass heater system and method, in particular, an intelligent biomass heater utilizing a minimal set of measurement sensors and a control strategy to actively modulate incoming air, enhancing stove combustion performance, and thereby eliminating user-error as a factor for emissions production. The heater implements methods to estimate critical performance metrics such as the heat release rate, instantaneous stove efficiency, combustion stoichiometry and biomass fuel moisture content using combinations of sensor reading such as the heater temperature, weight and airflow rates. These parameters are used in a feedback control algorithm to optimize the variable application of combustion air and reduce the burden on the operator by providing recommendations for refueling and replacement of components through automated, intelligent decision-making. The applied approach uses a combination of deep learning Neural Networks, Classification Models, and Reinforcement Learning to allow for a continuous prediction of emissions and operation mode and provide appropriate actuator adjustment.

IPC Classes  ?

• F24B 1/18 - Stoves with open fires, e.g. fireplaces
• F24B 1/19 - Supplying combustion-air
• C10B 53/02 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of cellulose-containing material
• F24B 1/187 - Condition responsive controls for regulating combustion

Abstract

The present invention provides a compound which is a class-lla histone deacetylases (HDAC) inhibitor, a process of making the compound, a composition containing the compound and radiolabeling the compound for use in positron emission tomography (PET) imaging, said compound having the structure: The present invention provides a compound which is a class-lla histone deacetylases (HDAC) inhibitor, a process of making the compound, a composition containing the compound and radiolabeling the compound for use in positron emission tomography (PET) imaging, said compound having the structure:

IPC Classes  ?

• C07D 271/06 - 1,2,4-OxadiazolesHydrogenated 1,2,4-oxadiazoles
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4245 - Oxadiazoles
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A method of controlling a data center having a cold air cooling system, and at least one containment structure, comprising: determining a minimum performance constraint; determining optimum states of the cold air cooling system, a controlled leakage of air across the containment structure between a hot region and a cold air region, and information technology equipment for performing tasks to meet the minimum performance constraint, to minimize operating cost; and generating control signals to the cold air cooling system, a controlled leakage device, and the information technology equipment in accordance with the determined optimum states.

IPC Classes  ?

• H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
• G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators

Abstract

The present disclosure is directed to a microwell array comprising a plurality of wells allowing for single cell genomics and methods for using such a microwell array in single cell genomics.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1404 - Handling flow, e.g. hydrodynamic focusing
• G01N 15/10 - Investigating individual particles

Abstract

The disclosure relates to enhancing alkalinity of brine, e.g. seawater, using bipolar membrane electrodialysis (BPMED) without removing divalent cations that otherwise cause scaling. In one embodiment, a BPMED is employed wherein the brine volumetric flow rate through a basification compartment is greater at a given current density than that through a brine compartment which increases the pH of the brine output while keeping it below the precipitation pH. In one embodiment, the spacer located in the basification compartment is thicker than spacers elsewhere in the BPMED so as resist membrane distortion due to the increased hydrostatic pressure in the basification compartment given the greater volumetric flow. The brine output having increased alkalinity can be returned to the ocean to mitigate acidification and enable capture of atmospheric carbon dioxide.

IPC Classes  ?

• B01D 61/44 - Ion-selective electrodialysis
• B01D 61/46 - Apparatus therefor
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• C02F 1/66 - Treatment of water, waste water, or sewage by neutralisationTreatment of water, waste water, or sewage pH adjustment
• C02F 103/06 - Contaminated groundwater or leachate
• C02F 103/10 - Nature of the water, waste water, sewage or sludge to be treated from quarries or from mining activities

Abstract

A pHI sensor system, Integrated Circuit (IC) chip, and a method are provided. Embodiments of the pH sensor may a first p-channel ion-sensitive transistor (IST)-operational-transconductance-amplifier (PIOTA) and a second PIOTA. Each PIOTA may further include a p-channel IST, an n-channel load transistor having a source and drain, wherein each PIOTA may have a drain-to-source resistance different from each other. Each PIOTA may further include an operational-transconductance-amplifier (OTA). A differential sensor may be connected to the outputs of both PIOTAs, and an output from the differential sensor may indicate a change in pH. Each PIOTA may further have an n-type substrate, a potential of which may be varied to control sensitivity of pH change detection. The NMOS load transistors of one or both of the PIOTAs may be selected from a plurality of NMOS load transistors to enhance sensitivity.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 27/416 - Systems

Abstract

Provided is a method for making a conductive ink. The conductive ink may be made by reacting copper sulfate with sodium carbonate to obtain copper carbonate; reacting the copper carbonate with formic acid to obtain copper formate particles; and forming an ink. Also provided are inks made by a method described herein.

IPC Classes  ?

• C09D 11/52 - Electrically conductive inks
• H01B 1/20 - Conductive material dispersed in non-conductive organic material
• H05K 1/09 - Use of materials for the metallic pattern
• B41M 5/00 - Duplicating or marking methodsSheet materials for use therein
• B41M 7/00 - After-treatment of printed works, e.g. heating, irradiating
• C09D 11/033 - Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
• C09D 11/037 - Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment

Abstract

Embodiments herein include a substrate; a semiconductor layer formed over the substrate; a source formed in the semiconductor layer; a drain formed in the semiconductor layer, whereon the drain is disposed laterally relative to the source; and a gate.

IPC Classes  ?

• H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
• H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Abstract

A system and method for modeling neuronal synaptic functionality at least partially instantiated on an optimized computation core of one or more high-speed processors. The synaptic model is preferably created as a neural net and includes, at least, a presynaptic component with a presynaptic target having, at least, a plasticity parameter and activity spike strength. The model also includes a retrograde signaling component with a retrograde messenger that selectively generates a molecular uptake signal, and a postsynaptic receptor component. The retrograde messenger acts on a presynaptic target to modulate the plasticity parameter and activity spike strength of the presynaptic component based upon a calculated molecular uptake at the postsynaptic receptor component to generate the molecular uptake signal which is then transmitted to the presynaptic component.

IPC Classes  ?

• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

An integrated matrix transformer for point-of-load converters is provided. The matrix transformer has a smaller surface area and a reduced core volume that lowers core losses. The matrix transformer's winding pattern produces a larger magnetizing inductance which aids in attaining better accuracy for gate pulse generation on the synchronous side of a point-of-load converter and mitigates power reversal issues present in traditional point-of-load converters using traditional matrix transformers. A reduction of circulating current in the primary side is also achieved. The matrix transformer comprises: a plurality of elemental transformers, each elemental transformer comprising a core, primary and secondary, linked through upper and lower members. The elemental transformers are magnetically coupled through the upper and lower members such that a flux induced by primary has a return path through one other core. The primaries are wired in series, and the secondaries in parallel.

IPC Classes  ?

• H01F 27/28 - CoilsWindingsConductive connections
• H01F 27/24 - Magnetic cores

Abstract

Disclosed are agents and methods of using the agents to treat or prevent pain and/or induce anesthesia. The agents may be peptides, siRNAs, and/or shRNAs that target adaptin protein 2-clathrin mediated endocytosis (AP2-CME). Peptides of the present disclosure may contain the following sequence X1X2X3X4LX5 (SEQ ID NO:7), where X1 is D, E, S, or T, where the D, E, S, and/or the T is optionally phosphorylated, X2, X3, and X3 are independently chosen from any amino acid.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 23/00 - Anaesthetics
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

A clinical personal protection equipment (PPE) system, worn by a healthcare provider, that can include a data display and selectively controls medical equipment. The system includes a computer platform that selectively communicates with a network, such as a Wifi network, and selectively communicates with and controls one or more electronic devices, such as an interactive rotating hemostatic valve and Tuohy-Borst adapter. The headset fits about the head of user and includes a face shield. A camera is located on the headset and is in communication with the computer platform, the camera creating visual data of a forward view from the headset and transmitting the visual data to the computer platform.

IPC Classes  ?

• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Abstract

4-pyrrolylpyridine, a novel anion sensor, displays a substantial color loss upon addition of sodium sulfite in aqueous solvents. A variety of anions were tested, including halides, phosphates, sulfates, and hydroxide, but all solutions remained unchanged aside from the sulfite, which displayed bleaching. Described here is a method for which the exact concentration of sulfites in a consumer product can be determined. The test is sensitive over a broad range of sulfites, from 0.84 ppm to over 10,000 ppm, and is accurate with a standard deviation of 0.01 ppm.

IPC Classes  ?

• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/14 - Beverages

Abstract

Embodiments of the present disclosure include metabeams with nonreciprocal dispersion. A host beam has a length along along a longitudinal axis and is configured to vibrate (oscillate) over its length. The vibration may be in a first direction perpendicular to the length of the host beam. A plurality of first resonators may be arranged in an array along the length of the host beam and extending from the host beam in a second direction which forms an angle (>0°) with respect to the first direction and an angle (>0°) with respect to the longitudinal axis of the host beam. Each first resonator has an arm having a first end attached to the host beam and an arm axis. The arm has a stiffness in the first direction which is selectively variable. A mass may be attached to the arm at a location which is spaced from the first end by a first distance. The stiffness of each first resonator arm is configured to be varied to impart nonreciprocal dispersion in the host beam.

IPC Classes  ?

• E04B 1/28 - Structures comprising elongated load-supporting parts, e.g. columns, girders, skeletons the supporting parts consisting of other material

Abstract

A computer-implemented methods and systems are provided for predicting flow characteristics in a vasculature. The method includes obtaining time-series angiography data of a vasculature; determining vessel wall geometry within the vasculature; generating, using one or more processors, a set of collocation points within the time-series angiography data co-registered with the vessel wall geometry; and determining, using the one or more processors, a flow velocity and pressure at each collocation point using a physics-informed neural network (PINN) having an objective function based on the Navier-Stokes equation, the convection equation, and boundary conditions including the vessel wall geometry and the angiography data. In some embodiments, determining the flow velocity and pressure at each collocation point comprises minimizing a difference between a contrast intensity measured at each collocation point of the angiography data and an imputed contrast intensity calculated from the PINN-determined flow velocity and pressure at each collocation point.

IPC Classes  ?

• A61B 5/026 - Measuring blood flow
• A61B 5/021 - Measuring pressure in heart or blood vessels
• G06T 7/10 - SegmentationEdge detection
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06T 7/60 - Analysis of geometric attributes
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• G16H 50/40 -
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

A microelectromechanical (MEMS) transducer includes a substrate, a moveable electrode supported by the substrate, and a pair of fixed electrodes supported by the substrate, each fixed electrode of the pair of fixed electrodes being configured as a bias or sense electrode. The pair of fixed electrodes are disposed in a stacked arrangement. An end of the moveable electrode is configured for vibrational movement along the stacked arrangement during excitation of the moveable electrode. The pair of fixed electrodes are laterally spaced apart from the end of the moveable electrode to establish a capacitance indicative of the vibrational movement.

IPC Classes  ?

• H04R 19/04 - Microphones
• B81B 3/00 - Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes

Abstract

Systems and methods for maintaining an electronic health records system, including a server storing a medical records database. Requests for medical data for a patient in a master problem list are received from a user device, and appropriate list permissions are determined and granted for hierarchical derivative problem lists. Annotated data is received at the server from a user device based on annotations made to a derivative problem list, and problem lists are updated with the received annotated data in real time. The received annotated data is compared with current entries using natural language processing to detect duplicate entries, the duplicate entries are iteratively detected and removed from the master problem list, and non-duplicate entries are stored in authorized derivative problem lists based on the natural language processing and list update permissions for each of the derivative problem lists.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records