A laboratory system or device comprising a control unit for controlling operation of the system or device, and a storage unit connected to the control unit and containing instruction for each assay type of the control type to be used when running said assay type, and, for each control type, an allocation rule for the control type. The control unit receiving at least one assay order comprising instructions to run at least one assay type on the system or device, determining for the at least one assay type comprised in the at least one assay order, the control type to be used, and the corresponding allocation rule for said control type, scheduling an assay run comprising instructions to include the determined control type based on the determined allocation rule, and controlling the system or device to perform the scheduled assay run.
Methods of evaluating mRNA or cDNA are provided. Instead of evaluating the mRNA or cDNA as a whole, multiple distinct portions of the mRNA or cDNA (such as different exons or untranslated regions) are separately quantified. The separate quantities are then evaluated by a trained classifier, which converts the separate quantities to a composite score indicative of the expression level of the mRNA or corresponding cDNA.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16B 25/00 - ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
3.
METHOD FOR CONTROLLING AN ANTI DROPLET SYSTEM OF A PIPETTOR AND PIPETTOR WITH ANTI DROPLET SYSTEM CONTROL
A method for controlling a laboratory system or device comprising at least one pipettor with a pressure sensor, at least one humidity sensor, at least one temperature sensor, and a control unit. The control unit receiving a humidity value from the humidity sensor and a temperature value from the temperature sensor, comparing the pair of humidity and temperature values with a threshold database connected to the control unit, the threshold database comprising, for different pairs of humidity and temperature values, instructions to activate or deactivate an anti droplet control system of the pipettor, determining if the anti droplet system of the pipettor has to be activated or deactivated, activating or deactivating said anti droplet system of the pipettor.
Disclosed herein are techniques for facilitating a clinical decision for a patient based on identifying a group of patients having similar attributes as the patient. The group of patients can be identified using information from a predictive machine learning model that performs a clinical prediction for the patient. At least some of the attributes of the group of patients can be output to support a clinical decision. The attributes may include, for example, biography data of the patient, results of one or more laboratory tests of the patient, biopsy image data of the patient, molecular biomarkers of the patient, a tumor site of the patient, and a tumor stage of the patient.
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
5.
LABORATORY SYSTEM OR DEVICE WITH IMPROVED SECURITY FEATURES AND METHOD FOR IMPROVING SECURITY IN A LABORATORY SYSTEM OR DEVICE
A method for increasing operational security of a laboratory system or device comprising: a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably along a first axis Y between an open position (O) and a closed position (C) and arranged stacked with respect to a second axis Z perpendicular to the first axis Y, and having each a position sensor (P2, P3) for determining the closed position (C) of the respective reagent drawer (2, 3), at least one robotic handler head (4) movably arranged in the reagent storage area at least along the first axis Y and the second axis Z a control unit (5) configured to control the operation of the robotic handler head (4) and connected to the position sensors (P2, P3), the method comprising the steps of defining for each reagent drawer (2, 3) a first forbidden zone along the first axis Y (Y) and a second forbidden along the second axis Z (Z2, Z3), determining by means of the position sensors (P2, P3) if the reagent storage drawers (2, 3) are in the closed position (C), and control the operation of the handler head (4).
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
6.
COMPUTER IMPLEMENTED METHOD FOR DESIGNING A COMPLEX PART OF AN IN-VITRO DIAGNOSTIC INSTRUMENT
A computer implemented method for designing a complex part of an in-vitro diagnostic instrument is disclosed. The method includes retrieving at least one target constraint, retrieving at least one set of input parameters, determining at least one design solution of the complex part by using at least one iterative algorithm considering the input parameters, comparing the candidate complex part to the target constraint, and rating the candidate complex part depending on the comparison.
A machine learning and/or deep learning framework forecasts epidemic or pandemic cases and deaths. Multiple open data sources relevant for the pandemic or epidemic evolution in a geographic area, such as the United States or another country or region, can be processed to extract a plurality of features, such as localized (i.e., county level, city level, regional level, province level, etc.) cases and deaths, demographics and socioeconomic factors, non-medical interventions, and mobility (i.e., from cell phone and/or GPS data). The learning can be used to predict future cases and deaths at localized levels and to recommend healthcare resources that may be needed.
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
A method for controlling an anti droplet system of a laboratory system or device comprising at least one air displacement pipettor with a pressure sensor and a control unit for controlling operation of the pipettor, the method comprising the following steps controlling the pipettor to be moved such that the pipettor tip is immerged in a fluid to be aspirated, aspirate a predetermined volume of fluid, move the pipettor such that the pipettor tip is emerged from the fluid, continuously monitoring the pressure above the fluid column in the pipettor tip and generating pressure curve over time, and determining if a pressure increase above the fluid column has been detected.
A laboratory system or device, comprising a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably between an open position (O) and a closed position (C), each of the reagent drawers comprising receptacles for a plurality of reagent cartridges (RC1, RC2), and at least two locking mechanisms (4, 5) for respectively locking/unlocking the at least two reagent drawers (2, 3) when in the closed position (C), at least one robotic handler (6) and a control unit (7), wherein the reagent storage area (1) is subdivided in a loading zone (LZ), a storage zone (SZ) and a pipetting zone (PZ), and the reagent storage area (1) further comprises a handling zone (HZ).
The present invention describes a secondary tube tray for use in an automated processing system, the tray comprising a base module and a secondary tube insert. Furthermore, the present invention describes a secondary tube handling module of an automated processing system for automatically processing biological sample, and a method of handling secondary tubes for use in automatically processing biological sample in an automated processing system.
B65C 9/02 - Devices for moving articles, e.g. containers, past labelling station
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
The present disclosure is concerned with data evaluation tools, methods for analyzing a dataset, and a computer readable medium comprising a computer program code that when run on a data processing device carries out the method of the disclosure as well as a device for carrying out the method of the disclosure. The methods and devices disclosed herein are used in analytical systems that analyze biological samples.
G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
G06F 16/28 - Databases characterised by their database models, e.g. relational or object models
G16B 40/00 - ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
Disclosed is a dual-labeled signal probe comprising an electron transfer moiety (ETM) and an optical signaling moiety (OSM). Upon binding of a target analyte to the signal probe, the composition is transported to an electrode surface. In some embodiments, the ETM and OSM are then each excited by applying an electrical voltage to the electrode. In some embodiments, the ETM signal and OSM signal are then detected using a single detector (or more than one detector), allowing the presence or absence of the target analyte to be determined. In some embodiments, the ETM signal and OSM signal are correlated before determining the presence or absence of the target analyte. In some embodiments, the dual-labeled signal probe permits real-time detection using an end-point electrochemical detection system. In some embodiments, the dual-labeled signal probe may be used to assess the location and density of capture probes on an electrode.
Techniques for patient data management include obtaining medical history data of patients from a database, the medical history data including a history of one or more diagnosis events, one or more treatment events, and a clinical outcome event for each patient of the patients. For each patient, based on the medical history data, a computing system generates a patient pathway that includes a graph including nodes of one or more diagnosis events, the one or more treatment events, and the clinical outcome event. The computing system receives, via an interface, one or more criteria to select a subset of the patient pathways of the patients. The computing system selects, based on the one or more criteria, graphs representing the subset of the patient pathways. The computing system aggregates the subset of the patient pathways into a merged graph. The computing system displays the merged graph in the interface.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
20.
INSTRUMENT FOR PROCESSING CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM
In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01L 7/00 - Heating or cooling apparatus; Heat insulating devices
C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
21.
METHOD FOR PROCESSING A BIOLOGICAL SAMPLE WITH MAGNETIC PARTICLES
The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.
A machine learning model for traversing a decision tree, the machine learning model trained from a structured data set including a first set of key-value pairs and subject-specific criteria using the key-value pairs. The first set of key-value pairs is transformed into a second set of key-value pairs, which are projected to a subject-specific point within a multi-dimensional space. The decision tree includes decision and leaf nodes. Each leaf node is connected to a root node via a leaf-node-specific trajectory. Each decision node corresponds to a criterion using a value in the second set of key-value pairs. For each leaf node, a leaf-node-specific point within the multi-dimensional space is determined using the leaf-node-specific trajectory, and a similarity score is determined using the leaf-node-specific and subject-specific points. A subset of the leaf nodes is identified using the scores. State or protocol information for each leaf node in the subset is retrieved.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
24.
METHODS FOR PERFORMING TEMPERATURE MULTIPLEXED PCR WITH INCREASED SENSITIVITY
The present invention describes methods for temperature multiplexed PCR for detection and quantitation of target nucleic acids with increased sensitivity. The methods are performed by contacting the sample with probes designed for temperature multiplexed PCR, measuring the fluorescence at multiple temperatures, subtracting signals to obtain calculated signals for each target of interest. Furthermore, the methods comprise obtaining a baseline of the first fluorescent signal, and adjusting the calculated signals using the obtained baseline of the first fluorescent signal to obtain a baseline shifted calculated signals.
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
An instrument for automatically dissecting a biological specimen on a slide. The instrument comprises at least one imaging system. The imaging system comprises at least one camera configured for sequentially imaging at least one image of the slide at a plurality of slide positions. The imaging system comprises a relay lens system having a fixed focal length. The relay lens system is configured for relaying an impinging light beam from the slide to the camera. The instrument further comprises a movable xy-stage configured for setting the slide position. The instrument further comprises at least one processing unit configured for generating a full slide image by stitching the sequentially imaged images of the slide. Further, a method for automatically dissecting a biological specimen on a slide is proposed.
In some embodiments, methods, systems, software and uses are provided for synchronizing medical images displays. An input identifying a region of interest in a first medical image is received. A second region of interest in a second medical image is determined based the first region. The first medical image and a first indication of the first region are displayed in a first viewport of a GUI. The second medical image and a second indication of the second region are displayed in a second viewport of the GUI. A display adjustment input is received to adjust the displaying of one of the first or second region of interest. Based on the display adjustment input and the correspondence information, an adjustment of the displaying of the first region of interest in the first viewport and an adjustment of the displaying of the second region of interest in the second viewport is implemented.
A61B 6/46 - Arrangements for interfacing with the operator or the patient
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
31.
Display screen or portion thereof with graphical user interface for patient pathway reconstruction and aggregation
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
35.
Compositions and Methods for Detecting Hepatitis Delta Virus by a Dual-Target Assay
Methods for the rapid detection of the presence or absence of Hepatitis Delta Virus (HDV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the HDV Ribozyme domain and the HDV Hepatitis Delta Antigen (HDAg) gene, along with kits are provided that are designed for the detection of HDV.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A laboratory instrument for processing a sample is proposed. The laboratory instrument comprises at least one level sensor configured for generating at least one level signal. The laboratory instrument further comprises at least one evaluation and control unit configured for evaluating the level signal thereby determining at least one item of tilt information on the laboratory instrument. The evaluation and control unit is further configured for determining at least one change in the level signal thereby detecting interfering influences on the laboratory instrument.
The present invention relates to compositions and methods to detect the Acinetobacter calcoaceticus- Acinetobacter baumannii complex species and to identify the most prevalent carbapenemases found in carbapenem resistant Acinetobacter calcoaceticus-baumannii (CRAB) such as blaOXA-23-like, blaOXA-24-like, blaOXA-58-like and blaNDM-like by a multiplex real-time PCR assay.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
The present disclosure relates to reversible sealing of a microfluidic chip used for thermal incubation of an aqueous sample suspected to contain a target nucleic acid. The microfluidic chip contains a flow channel and a plurality of reaction compartments, into which the sample and a displacement fluid are introduced through an inlet port scalable by means of a sealing agent having a melting point above room temperature.
The present invention provides compositions and methods relating to novel digital PCR (dPCR) assay designs (droplet digital or other systems) for the detection and quantitation of multiple hepatitis B virus (HBV) gene targets. The compositions and method can further include non-extendible blocker oligonucleotides for reduction of non-specific inter-amplicon extension.
C12Q 1/6816 - Hybridisation assays characterised by the detection means
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
41.
POLYPEPTIDE TAGGED NUCLEOTIDES AND USE THEREOF IN NUCLEIC ACID SEQUENCING BY NANOPORE DETECTION
The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.
A system, a method, and a user interface are described for customizing external quality control testing for a diagnostic system. Quality control assays must be run for each assay panel capable of being run on a diagnostic instrument. Each quality control assay for each assay panel is given a desired frequency and a desired rotation. A QC rule customization module allows a user to create, manage, delete, or view QC rules. Reminders can be sent for upcoming quality control assays that are due. Alerts are sent if the quality control assays are missed.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The disclosure relates to a method for optimizing sample distribution in a laboratory system, the method comprising: retrieving, at a control unit of the laboratory system, one or more test requests for each sample provided to the laboratory system; controlling, by the control unit, a transport system of the laboratory system to convey the provided samples to one or more sample buffer units; creating, by the control unit, run instructions to run one or more requested tests on selected samples on a test plate based on optimization criteria; transmitting, by the control unit, the run instructions to an analyzer of the laboratory system; and controlling, by the control unit, the transport system to convey the selected samples for which one or more requested tests shall be executed from a sample buffer unit to the analyzer.
The invention relates to a method of diagnosing or determining the prognosis of cancer in a patient, the method comprising processing, using RNA‐sequencing and a first machine learning model, the genomic data of the patient to determine at least one of a first cancer type or degree of cancer and processing, using histopathology and a second machine learning model, the biopsy image data of the patient to determine at least one of a second cancer type or degree of cancer and comparing the determined first type or degree of cancer with the determined second type or degree of cancer and correlating the two.
A method for monitoring the sealing of a container in a system or device is described. The method includes the following steps: controlling the heating element to heat a heating stamp to a predetermined sealing temperature, monitoring the temperature of the heating stamp, determining a temperature over time curve of the heating stamp by means of at least one temperature sensor, determining at least one characteristic of the temperature over time curve, comparing the determined at least one characteristic of the temperature over time curve with a reference value, and determining a sealing property of the sealing of the container based on said comparison of the determined at least one characteristic of the temperature over time curve with the reference value.
The subject disclosure presents systems and methods for improved meso-dissection of biological specimens and tissue slides including importing one or more reference slides with annotations, using inter-marker registration algorithms to automatically map the annotations to an image of a milling slide, and dissecting the annotated tissue from the selected regions in the milling slide for analysis, while concurrently tracking the data and analysis using unique identifiers such as bar codes.
A gripping device (150) configured for gripping at least one slide (168) is disclosed. The gripping device (150) comprises: • at least one first gripping element (110), wherein the first gripping element (110) comprises at least one first contact surface (112) for gripping the slide (168); • at least one second gripping element (134), wherein the second gripping element (134) comprises at least one second contact surface (136) for gripping the slide (168), wherein the second gripping element (134) further comprises at least two protrusions (160) which respectively extend essentially perpendicular to the second contact surface (136), wherein the at least two protrusions (160) are located on opposing ends (162) of the second contact surface (136), wherein the at least two protrusions (160) are configured for centering the slide (168) during gripping the slide (168) via the gripping device (150); wherein the first gripping element (110) and the second gripping element (134) are linearly movable relative to one another, wherein the first contact surface (112) of the first gripping element (110) and the second contact surface (136) of the second gripping element (134) face each other.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical, biological and biochemical preparations for scientific purposes and for research purposes; in vitro diagnostic reagents for use in research and science; chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; chemical reagents for diagnostic tests and test kits for the determination of genetic information for scientific or research purposes; assays and reagents for use in genetic research; reagents and nucleotides for the sequencing of nucleic acids for scientific or research purposes
49.
BASE MODULE AND TRAY INSERT OF A MULTIPURPOSE TRAY FOR AN AUTOMATED PROCESSING SYSTEM, MULTIPURPOSE TRAY FOR AN AUTOMATED PROCESSING SYSTEM, AND METHOD OF SIMPLIFIED LOADING/UNLOADING OF A MULTIPURPOSE TRAY INTO/FROM AN AUTOMATED PROCESSING SYSTEM
The present invention describes a base module (100) and a tray insert (200, 300, 400) of a multipurpose tray (100) for an automated processing system, such as an analytical, pre-analytical or post-analytical processing system, as well as to a multipurpose tray comprising such base module and such tray insert, wherein the tray insert can be particularly used for holding a plurality of reagent or sample tubes to be processed in the automated processing system. The present invention further relates to a method of simplified loading/unloading of such a multipurpose tray into/from the automated processing system.
Methods for the rapid detection of the presence or absence of Human Parainfluenza Viruses (HPIV), including HPIV 1-4 in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting HPIV 1-4, and kits are provided that are designed for the detection of target regions of HPIV 1-4. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of HPIV 1-4.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
Computer-implemented methods of providing a disease diagnosis or prognosis for a patient are described. These comprise generating individual networks, each individual network comprising a plurality of nodes and edges between pairs of the nodes, wherein each node is indicative of a biological factor in biological data for an individual, and each edge is indicative of a relationship between a pair of biological factors corresponding to the nodes that the edge connects for the respective individual; determining the value of one or more similarity metrics between one or more individual networks generated for the patient and one or more individual networks generated for other individuals in the plurality of individuals; and predicting a diagnosis or prognosis for the patient using a machine learning model that takes as input the values of one or more similarity metrics.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
53.
MUTANT DNA POLYMERASE(S) WITH IMPROVED STRAND DISPLACEMENT ABILITY
Disclosed are DNA polymerases having increased 5′-3′ strand displacement activity and substantially reduced 5′-3′ exonuclease and endonuclease activity relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, oligonucleotide primers and oligonucleotide probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).
C12Q 1/6893 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
55.
MEDICAL TREATMENT METRIC MODELLING BASED ON MACHINE LEARNING
In one example, an apparatus comprises a treatment metric model database that stores a plurality of treatment metric models, each of the plurality of treatment metric models being generated for a first cluster of cluster features vectors, each cluster feature vector representing a distribution for each of a plurality of data categories of patients data represented by patient feature vectors clustered in a second cluster. The apparatus is further configured to: receive patient characteristics features data of a patient; identify a first treatment metric model based on the patient characteristics features data of the patient; input the first patient characteristic features data and data representing a range of administrations of the treatment to the first treatment metric model to compute a range of the treatment metric; and select an administration of the treatment from the range of administrations of the treatment having optimal treatment metric.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G06F 17/18 - Complex mathematical operations for evaluating statistical data
G06F 18/2113 - Selection of the most significant subset of features by ranking or filtering the set of features, e.g. using a measure of variance or of feature cross-correlation
G06F 18/23213 - Non-hierarchical techniques using statistics or function optimisation, e.g. modelling of probability density functions with fixed number of clusters, e.g. K-means clustering
G06F 18/2411 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on the proximity to a decision surface, e.g. support vector machines
G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
In one embodiment, a method includes indexing a whole slide image dataset to generate one or more dataset embeddings corresponding to one or more respective regions of one or more whole slide images. Each dataset embedding includes a feature vector mapping the respective region to a feature embedding space. The method includes accessing a query image and generating an embedding for the query image that includes a feature vector mapping the query image to the feature embedding space. The method includes identifying result tiles by comparing the embedding for the query image to one or more of the dataset embeddings. The comparison is based on one or more distances between the embedding for the query image and the one or more of the dataset embeddings in the feature embedding space. The method includes generating a user interface including a display of the result tiles.
G06F 16/583 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually using metadata automatically derived from the content
G06F 16/51 - Indexing; Data structures therefor; Storage structures
G06F 16/532 - Query formulation, e.g. graphical querying
G06F 16/535 - Filtering based on additional data, e.g. user or group profiles
The present invention relates to methods for the specific lysis of eukaryotic cells in a sample containing microorganisms such as bacterium and fungus by incubating the sample in a buffer of around pH 9 that contains a non-ionic detergent.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.
Methods for the rapid detection of the presence or absence of Monkeypox Virus (MPXV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the MPXV F3L gene and the MPXV B21R gene, along with kits are provided that are designed for the detection of MPXV.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
60.
METHOD FOR COMPENSATION NON-VALID PARTITIONS IN dPCR
A method for compensating defective partitions of a microfluidic chip and a sample processing system for performing the method are disclosed. The microfluidic chip includes at least one array of partitions. The method includes generating image data of the microfluidic chip by imaging the microfluidic chip with an imaging device, providing a mask for at least one area of partitions to a data processing unit, applying the mask to (a) the image data, (b) at least one feature extracted from the image data, or (c) at least one value extracted from the image data, to generate masked data, and generating an analytical result for the sample using the masked data.
System and methods in this disclosure identify leakage from one partition to surrounding partitions. Detecting leakage may include input data describing the location of the partition, the fluorescence intensity, and whether the partition is positive for an analyte. A machine learning model may be trained on an extensive input data set to identify partitions that have leakage or a high probability of leakage. In some embodiments, features used in the machine learning model include values that describe a neighborhood around the partition and not merely the partition itself.
The present invention provides a method comprising the steps of a) providing a nucleic acid comprising 5fC, 5hmC, or 5caC, b) providing one reactant comprising two reactive groups wherein the first reactive group is capable of reacting with the formyl hydroxymethyl or carboxyl group, and the second reactive group is a nucleophilic group, c) reacting said first reactive group with the formyl, hydroxymethyl or carboxyl group thereby resulting in a modified 5fC, 5hmC, or 5caC, d) reacting said second reactive group with the C6 position of said modified 5fC, 5hmC, or 5caC, thereby obtaining a bicyclic or tricyclic molecule comprising a 5,6-di-hydro Cytosine entity, and e) deaminating said 5,6-di-hydro Cytosine entity to a 5,6 di-hydro-Uracil entity.
A gripper system includes: a first gripper finger having a first groove, a second groove, and a third groove; and a second gripper finger having a first groove, a second groove, and a third groove, wherein the gripper is configured to apply a first compression force against length edges of a slide in a widthwise direction at the first grooves, the gripper is configured to apply a second compression force against width edges of the slide in a lengthwise direction at the second grooves, the gripper is configured to apply a third compression force against width edges of the slide in a lengthwise direction at the third grooves, and the third compression force against the width edges of the slide in the lengthwise direction is an orientation in which the slide is rotated perpendicular to an orientation corresponding to a gripping position of the second grooves.
The present invention allows for the expansion of multiplexing capabilities of common PCR devices by using fluorogenic PCR probes made of large Stokes shift (LSS) fluorescent dyes. With this approach, no changes of the hardware or software components in the instrument are required.
A biomedical knowledge graph system, the system including a computer database of records, the records comprising nodes of biomedical entities and connections between the entities representing biomedical relationships. One or more processors are programmed and configured to extract data from a plurality of data sources, determine biomedical entities and relationships between the entities based on analyzing the data, wherein analyzing the data comprises searching for predetermined identifiers or patterns in the data. Based on the determined biomedical entities, assigning each biomedical entity to a cluster of biomedical entity types. The one or more processors are configured to identify a context for each of the identified biomedical entities based on the assigned cluster and based on elements of the expression of the biomedical data within which the entity is expressed. Based on the identified context and type of the biomedical entity, incorporating records of nodes and connections between nodes into the knowledge graph, the nodes representing biomedical entities and the connections representing biomedical relationships between the entities structured according to the predefined schema.
Systems and methods are provided for managing patient data. The system integrates medical data from multiple sources to a unified patient database. Structured and unstructured medical data is obtained, enriched (e.g., by designating data field types, standardizing data types or terminology, and the like), and stored to the unified patient database. The data retrieved from the disparate sources is stored to data elements in the unified patient database in a network of connected objects including data about tumor masses, treatments, reports, medical history, and diagnoses. The data in the unified patient database is used to display patient data in user-friendly interface views, including a patient journey view that displays patient data in a chronological fashion organized by data types. The different interface views can be traversed to display patient data originating from disparate sources with ease, to improve the clinical decision making process.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present disclosure relates, in general, to novel and easily accessible fluorescent compounds with large Stokes shift (LSS) and thermostable fluorescence for expanding the multiplexing capabilities of fluorescence-based nucleic acid detection technologies. Moreover, conjugates, probes and FRET pairs comprising these fluorescent compounds as well as methods for amplification and detection of a target nucleic acid utilizing these fluorescent compounds and methods of labeling are also provided.
The present disclosure relates, in general, to the methods for the rapid detection of the presence or absence of Lymphogranuloma Venereum (LGV)-causing serovars of Chlamydia trachomatis in a biological or non-biological sample. The methods can include performing an amplification step, a hybridization step, and a detection step. Furthermore, oligonucleotide primers and probes targeting the pmpH gene for the L serovars of Chlamydia trachomatis, along with kits are provided that are designed for the detection of L serovars.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
70.
FERROCENE LABELLED PRIMERS FOR ELECTROCHEMICAL DETECTION
The present invention provides novel primers in which a ferrocene label is attached to the primer. The ferrocene label is incorporated into the amplification product. When the amplification product incorporating the ferrocene label is denatured, it can bind to a capture probe and the presence or absence of the ferrocene label can be detected via electrochemical detection. The system avoids the use of a signal probe in a sandwich assay as historically used during electrochemical detection.
The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.
Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.
An event chain reaction system (128) is disclosed. The event chain reaction system (128) comprises: —at least one communication interface (156) configured for receiving at least one event stream (160), wherein the event stream (160) comprises at least one sequence of ordered events generated by at least one analytical system (112), wherein each event comprises information about a change in a state of the analytical system (112) and/or any of loaded resources; —at least one chain reaction component (158) comprising at least one chain matching element (162), wherein the chain matching element (162) is configured for recognizing at least one chain on the event stream (160), wherein the chain comprises a set of ordered events to be searched, wherein a first event of the chain defines a start event (166), wherein the chain matching element (162) is configured for identifying the start event (166) in the event stream (160) and, upon identifying the start event (166), the chain matching element (162) is configured for successively determining whether the other events of the chain match to one of the events of the event stream (160), wherein, in case all events of the chain are matched to events of the event stream (160), the chain matching element (162) is configured for triggering at least one reaction, wherein the reaction comprises generating information that a chain was matched and/or issuing a command to at least one component of the analytical system (112), wherein, in case one of the events of the chain is not matched, the chain matching element (162) is configured for resetting to its initial state and waiting for the start event (166). Further, a system (110) for monitoring and/or controlling, a computer implemented method and a computer program for determining at least one feature of at least one component of an analytical system (112), a computer implemented method and a computer program for monitoring and/or controlling at least one feature of at least one component of an analytical system (112) are disclosed.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
74.
Text entry assistance and conversion to structured medical data
A computer-implemented method is provided. The method comprises: receiving, from a text field of a user interface, input text strings containing medical data; identifying, based on language semantics and grammatical structure, a keyword and one or more data values from the input text strings; providing the keyword as an input to a query of a medical data category database to obtain one or more categories associated with the keyword, the one or more categories including a first category; retrieving, from a template database, a first template associated with the first category, the first template including one or more fixed blocks and one or more variable blocks; inserting a data value corresponding to the keyword into a variable block of the first template to generate a replacement text string; and displaying the replacement text string in place of the input text strings in the text field.
G06F 16/907 - Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually
G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A method for autonomous teach-in of at least one target position of a supply device (120) of a slide imaging apparatus (110) is disclosed. The slide imaging apparatus (110) comprises at least one imaging device (126, 128) configured to generate an image of a sample mounted on a slide (140). The target position is a position on the imaging device (126, 128). The slide imaging apparatus (110) comprises at least one operating system (170) configured for controlling operation of the supply device (120). The method comprises the following steps i) (186) providing at least six pre-defined positions by using the operating system (170); ii) (188) driving the supply device (120) to the six pre-defined positions until colliding with the imaging device (126, 128) by using the operating system (170) and detecting collisions with the imaging device (126, 128); iii) (190) evaluating the detected collisions by using the operating system (170), thereby determining the target position.
G05B 19/425 - Teaching successive positions by numerical control, i.e. commands being entered to control the positioning servo of the tool head or end effector
B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
76.
SYSTEMS AND METHODS FOR ASSESSING BAYS ON DIAGNOSTIC DEVICES
Disclosed are methods, systems and apparatuses in which a diagnostic instrument analyzes data collected over time, and based on that information, disables a bay, suggests a bay, puts a bay on standby or combinations thereof. In some embodiments, the method, system and apparatus allows the diagnostic instrument to have higher validity rates in the field and allows the provider to set up service calls, schedule maintenance and perform remote maintenance, as well as other functions based on the data collected over time.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
77.
CELL CLASSIFICATION USING CENTER EMPHASIS OF A FEATURE MAP
Techniques described herein include, for example, generating a feature map for an input image, generating a plurality of concentric crops of the feature map, and generating an output vector that represents a characteristic of a structure depicted in a center region of the input image using the plurality of concentric crops. Generating the output vector may include, for example, aggregating sets of output features generated from the plurality of concentric crops, and several methods of aggregating are described. Applications to classification of a structure depicted in the center region of the input image are also described.
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
A machine learning and/or deep learning framework was constructed and used to forecast COVID-19 cases and deaths. Multiple open data sources relevant for the pandemic evolution in a geographic area, such as the United States or another country or region, can be processed to extract a plurality of features, such as localized (i.e., county level, city level, regional level, province level, etc.) COVID cases and deaths, demographics and socioeconomic factors, non- medical interventions, and mobility (i.e., from cell phone and/or GPS data).
G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
The disclosure provides improved magnetic glass particles for use in nucleic acid capture, enrichment, analysis, and/or purification. Various modifications to the disclosed compositions and methods of using the same, as well as devices and kits are described.
H01F 1/34 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes, all of the foregoing excluding reagents used in connection with demineralized bone for purposes other than diagnostic applications; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific equipment, apparatus and instruments, namely, genome sequencer for scientific, pharmaceutical and medical research purposes; scientific instruments for use in scientific research, namely, nucleic acid sequencers, imaging devices and analyzers; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; laboratory equipment, namely, devices for analysis of nucleic acids and for dna sequencing; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; downloadable software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable software used in analyzing, managing and visualizing dna sequencing data; downloadable software used for preparation of nucleic acids libraries; computer hardware and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes
Disclosed herein are techniques for facilitating a clinical decision for a patient based on identifying a group of patients having similar attributes as the patient. The group of patients can be identified using information from a predictive machine learning model that performs a clinical prediction for the patient. At least some of the attributes of the group of patients can be output to support a clinical decision. The attributes may include, for example, biography data of the patient, results of one or more laboratory tests of the patient, biopsy image data of the patient, molecular biomarkers of the patient, a tumor site of the patient, and a tumor stage of the patient.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for healthcare providers for infectious disease surveillance, infection prevention and control,
antimicrobial stewardship Software as a service (saas) services for healthcare providers featuring software for infectious disease surveillance, infection
prevention and control, antimicrobial stewardship and laboratory management
84.
NON-REPLICATIVE TRANSDUCTION PARTICLES WITH ONE OR MORE NON-NATIVE TAIL FIBERS AND TRANSDUCTION PARTICLE-BASED REPORTER SYSTEMS
The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
85.
Method and device for sonicating a biological sample
The present disclosure relates to a device for sonicating a biological sample. In one embodiment, a sample tube holder is pivotally suspended in a mount of a sonication device, thus allowing for a rotational degree of freedom and/or lateral movement that provides an optimized contact area between the sonotrode and the sample tube. Also disclosed is a method for sonicating a biological sample using the device described herein.
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
B01F 35/42 - Clamping or holding arrangements for mounting receptacles on mixing devices
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable software for use therewith sold as a unit
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable software for use therewith sold as a unit
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Scientific and laboratory apparatus, devices and instruments for identifying, sequencing, analyzing, measuring and recording dna or other molecules for non-medical purposes, namely, genome sequencers; laboratory instruments, namely, devices for analysis of nucleic acids, namely, nucleic acid analyzers; laboratory apparatus, namely, nucleic acid sequencers; computer systems and downloadable software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes; downloadable computer software for use in analyzing, managing and visualizing dna sequencing data; laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers and downloadable operating software sold as a unit for use in laboratory operations Apparatus, devices and instruments for identifying, sequencing, analyzing, measuring and recording dna or other molecules for medical diagnostics purposes, namely, genome sequencers; medical diagnostic and analytical apparatus for medical diagnostic purposes; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, namely, nucleic acid analyzers and nucleic acid sequencers Scientific research and consultancy services related thereto in the fields of genome sequence analysis and reporting; medical research services in the fields of genome sequence analysis and reporting; providing dna screening for scientific research purposes; providing online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory instruments and computer systems for use in science and clinical research; consultancy, information and advisory services in the field of analysis of biomolecules as it relates to dna screening and genome sequence analysis and reporting Medical services for analysis of genetics; genetic testing for medical purposes; nucleic acid based testing for medical purposes; medical services in the field of nucleic acid analysis; medical services in the field of genetic screening
89.
MODIFIED NUCLEOSIDE PHOSPHATES WITH HIGH THERMAL STABILITY
The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside polyphosphates. The present invention also provides for methods for using the modified nucleoside polyphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.
The present invention relates to methods to improve detection of amplification products from Loop-mediated Amplification (LAMP) reactions by the use of nucleotide analogs that form duplex structures that nucleic acid polymerase enzymes do not recognize efficiently.
A computer-implemented method for quality control of at least one digital image of a sample (112) mounted on a slide (114) is proposed. The method comprises the following actions:
a) Providing at least one digital image of the sample (112) mounted on the slide (114) using at least one imaging device (116) of a slide imaging apparatus (110);
b) Determining quality of the digital image by determining sharpness values of subregions of at least one region of interest of the digital image by using at least one edge detection image filter and comparing the sharpness values within the region of interest, wherein the quality of the region of interest is classified depending on the comparison;
c) Generating at least one indication depending on the classification of the quality, wherein actions b) and c) are performed automatically.
G06T 15/00 - 3D [Three Dimensional] image rendering
G06T 5/20 - Image enhancement or restoration by the use of local operators
G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
G06V 10/56 - Extraction of image or video features relating to colour
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
H04N 23/67 - Focus control based on electronic image sensor signals
92.
METHODS FOR CLUSTERING MELTING CURVES TO IDENTIFY GENOTYPES
Automated methods for genotyping melting curves are described. Melting curves are processed and difference matrices are compiled based on the processed matrices. The difference matrices are used to compile a cluster matrix and the cluster matrix is filtered to determine clusters that are used for genotyping the melting curves.
Methods for the rapid detection of the presence or absence of Candida auris (CA) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the CA 5.8 s/ITS2 rRNA gene, along with kits are provided that are designed for the detection of CA.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
94.
COMPUTER-IMPLEMENTED METHOD FOR PERFORMING A CLINICAL PREDICTION
A computer-implemented method for performing a clinical prediction is disclosed. The method comprises the following steps: i) (110) retrieving input data via at least one communication interface (164) of a processing device (166), wherein the input data comprises multiple different modalities of a patient; ii) (114) processing the input data by using the processing device (166), wherein the processing comprises generating embedding modality representations from the input data by using at least one trainable data embedder, wherein the processing comprises combining the embedding modality representations using at least one aggregation network thereby generating the clinical prediction, wherein the aggregation network comprises at least one attention layer and/or at least one transformer layer; and iii) (118) generating an output of the clinical prediction by using the processing device (166).
G06N 3/04 - Architecture, e.g. interconnection topology
G16H 30/00 - ICT specially adapted for the handling or processing of medical images
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying positively charged tags from oligonucleotide probes, bound to target nucleic acids, are produced during PCR by the 5`-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique positively charged tags.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Chemical, biological and biochemical preparations for scientific purposes and for research purposes; in vitro diagnostic reagents for use in research and science; chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; chemical reagents for diagnostic tests and test kits for the determination of genetic information for scientific or research purposes; assays and reagents for use in genetic research; reagents and nucleotides for the sequencing of nucleic acids for scientific or research purposes
97.
AUTOMATED PARALLELIZED PROCESSING OF DECISION-TREE GUIDELINES USING ELECTRONIC RECORD
A machine learning model for traversing a decision tree, the machine learning model trained from a structured data set including a first set of key-value pairs and subject-specific criteria using the key-value pairs. The first set of key-value pairs is transformed into a second set of key-value pairs, which are projected to a subject-specific point within a multi-dimensional space. The decision tree includes decision and leaf nodes. Each leaf node is connected to a root node via a leaf-node-specific trajectory. Each decision node corresponds to a criterion using a value in the second set of key-value pairs. For each leaf node, a leaf-node-specific point within the multi-dimensional space is determined using the leaf-node-specific trajectory, and a similarity score is determined using the leaf-node-specific and subject-specific points. A subset of the leaf nodes is identified using the scores. State or protocol information for each leaf node in the subset is retrieved.
A method for controlling a laboratory system or device comprising at least one pipettor with a pressure sensor, at least one humidity sensor, at least one temperature sensor, and a control unit. The control unit receiving a humidity value from the humidity sensor and a temperature value from the temperature sensor, comparing the pair of humidity and temperature values with a threshold database connected to the control unit, the threshold database comprising, for different pairs of humidity and temperature values, instructions to activate or deactivate an anti droplet control system of the pipettor, determining if the anti droplet system of the pipettor has to be activated or deactivated, activating or deactivating said anti droplet system of the pipettor.
A laboratory system or device, comprising a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably between an open position (O) and a closed position (C), each of the reagent drawers comprising receptacles for a plurality of reagent cartridges (RC1, RC2), and at least two locking mechanisms (4, 5) for respectively locking/unlocking the at least two reagent drawers (2, 3) when in the closed position (C), at least one robotic handler (6) and a control unit (7), wherein the reagent storage area (1) is subdivided in a loading zone (LZ), a storage zone (SZ) and a pipetting zone (PZ), and the reagent storage area (1) further comprises a handling zone (HZ).
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
