Abstract

The present disclosure provides methods for profiling the nucleic acids bound to the ribosome by using electrophoresis to separate the nucleic acids bound to the ribosome from a cell lysate. Also, provided herein are devices that may be used to separate these nucleic acids from other parts of the cell and may be used in these methods.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6869 - Methods for sequencing

Abstract

A breast pump and method of manufacturing the breast pump are described. The breast pump includes a pair of pads configured to be applied to human breasts of a user, each of the pads containing sensors and actuators, a pressure generator configured to provide vacuum within a first predetermined range and compression within a second predetermined range to operate the actuators in each pad, a temperature control system, and an artificial intelligence (Al) control system configured to control, based on feedback from the sensors, the pressure generator to mimic intra-oral motion of an infant and the temperature control system.

IPC Classes  ?

• A61J 13/00 - Breast-nipple shields
• A61M 1/06 - Milking pumps

Abstract

A breast pump and method of manufacturing the breast pump are described. The breast pump includes a pair of pads configured to be applied to human breasts of a user, each of the pads containing sensors and actuators, a pressure generator configured to provide vacuum within a first predetermined range and compression within a second predetermined range to operate the actuators in each pad, a temperature control system, and an artificial intelligence (AI) control system configured to control, based on feedback from the sensors, the pressure generator to mimic intra-oral motion of an infant and the temperature control system.

IPC Classes  ?

• A61M 1/06 - Milking pumps

Abstract

A microbial platform for rare earth element bioaccumulation comprises a bacterial culture, a medium comprising methanol, inorganic phosphate, and a swarf pulp, wherein the platform is selective for bioaccumulation of a rare earth element.

IPC Classes  ?

• A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
• C09K 8/582 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of bacteria
• A01N 59/16 - Heavy metalsCompounds thereof
• C12N 1/04 - Preserving or maintaining viable microorganisms

Abstract

Various aspects described herein relate to a functionalized nanoscale substrate. The functionalized nanoscale substrate includes a functionalized surface of the substrate that includes a boronated portion.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

Various aspects described herein relate to a functionalized nanoscale substrate. The functionalized nanoscale substrate includes a functionalized surface of the substrate that includes a boronated portion.

IPC Classes  ?

• A61K 33/22 - Boron compounds
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents

Abstract

Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: In Formula I, R can be selected from: a substituted or unsubstituted (C1-C13)hydrocarbyl; the structure according to Formula II Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: In Formula I, R can be selected from: a substituted or unsubstituted (C1-C13)hydrocarbyl; the structure according to Formula II the structure according to Formula III Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: In Formula I, R can be selected from: a substituted or unsubstituted (C1-C13)hydrocarbyl; the structure according to Formula II the structure according to Formula III the structure according to Formula IV Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: In Formula I, R can be selected from: a substituted or unsubstituted (C1-C13)hydrocarbyl; the structure according to Formula II the structure according to Formula III the structure according to Formula IV Various aspects disclosed relate to an antibiotic adjuvant. The adjuvant includes the structure according to Formula I: In Formula I, R can be selected from: a substituted or unsubstituted (C1-C13)hydrocarbyl; the structure according to Formula II the structure according to Formula III the structure according to Formula IV and n is in a range of 1-10.

IPC Classes  ?

• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof
• A61K 38/12 - Cyclic peptides
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61P 31/04 - Antibacterial agents

Abstract

An apparatus and system are described to provide an in-memory computing non-volatile flash memory cell array used in a neural network. Each cell includes a Resistive RAM memory (RRAM) and a physical resistor formed from a high resistive material. The RRAM is programmed to either an on or off state in which the resistance is respectively significantly less or more than the resistor to permit the RRAM to act as a switch and allow for in-situ training. Multi-bit RRAM cells contain multiple RRAMs, each of which is connected to a resistor having a different resistance and read using the same input line. The resistors are formed from the same material as the resistor in the analog-to-digital converter used to read the array.

IPC Classes  ?

• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or

Abstract

An apparatus and system are described to provide an in-memory computing non-volatile flash memory cell array used in a neural network. Each cell includes a Resistive RAM memory (RRAM) and a physical resistor formed from a high resistive material. The RRAM is programmed to either an on or off state in which the resistance is respectively significantly less or more than the resistor to permit the RRAM to act as a switch and allow for in-situ training. Multi-bit RRAM cells contain multiple RRAMs, each of which is connected to a resistor having a different resistance and read using the same input line. The resistors are formed from the same material as the resistor in the analog-to- digital converter used to read the array.

IPC Classes  ?

• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or

Abstract

In one aspect, compounds and methods are described herein for treating gram negative bacteria having resistance to cationic antimicrobial peptides. In some embodiments, for example, compounds of formula I are provided. In another aspect, a treatment for a gram negative bacterial infection comprises a cationic antimicrobial protein (CAP) in conjunction with a compound of formula I.

IPC Classes  ?

• C07D 213/75 - Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• A61K 38/12 - Cyclic peptides
• A61P 31/04 - Antibacterial agents

Abstract

Various aspects according to the instant published patent application relate to a functionalized nanoscale diamond. The functionalized nanoscale diamond includes a functionalized surface. The functionalized surface includes a brominated portion and a hydroxylated portion. In further aspects, the brominated portion can be reacted with an amine to form an aminated nanoscale diamond.

IPC Classes  ?

• C01B 32/28 - After-treatment, e.g. purification, irradiation, separation or recovery
• C01B 32/26 - Preparation

Abstract

The present disclosure provides methods for profiling the nucleic acids bound to the ribosome by using electrophoresis to separate the nucleic acids bound to the ribosome from a cell lysate. Also, provided herein are devices that may be used to separate these nucleic acids from other parts of the cell and may be used in these methods.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 9/22 - Ribonucleases

Abstract

Various aspects according to the instant published patent application relate to a functionalized nanoscale diamond. The functionalized nanoscale diamond includes a functionalized surface. The functionalized surface includes a brominated portion and a hydroxylated portion. In further aspects, the brominated portion can be reacted with an amine to form an aminated nanoscale diamond.

IPC Classes  ?

• C01B 33/26 - Aluminium-containing silicates
• C01B 32/28 - After-treatment, e.g. purification, irradiation, separation or recovery

Abstract

Various embodiments disclosed relate to a premature infant mannequin with realistic movements. The present disclosure includes a premature infant mannequin with joints that simulate realistic movements, and methods of training neonatal staff with the premature infant mannequin.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 23/32 - Anatomical models with moving parts

Abstract

Various embodiments disclosed relate to a premature infant mannequin with realistic movements. The present disclosure includes a premature infant mannequin with joints that simulate realistic movements, and methods of training neonatal staff with the premature infant mannequin.

IPC Classes  ?

• G09B 23/32 - Anatomical models with moving parts

Abstract

A vertical semiconductor transistor is provided that includes: a source region, a drain region, and a body region formed in a semiconductor substrate; wherein the source region and the drain region are doped with a first type dopant; wherein the body region is doped with a second type dopant; and wherein the second type dopant has a doping profile within the body region that varies with distance from the source region.

IPC Classes  ?

• H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate

Abstract

A vertical semiconductor transistor is provided that includes: a source region, a drain region, and a body region formed in a semiconductor substrate; wherein the source region and the drain region are doped with a first type dopant; wherein the body region is doped with a second type dopant; and wherein the second type dopant has a doping profile within the body region that varies with distance from the source region.

IPC Classes  ?

• H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 29/167 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form further characterised by the doping material
• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate

Abstract

In one aspect, compounds and methods are described herein for treating gram negative bacteria having resistance to cationic antimicrobial peptides. In some embodiments, for example, compounds of formula I are provided. In another aspect, a treatment for a gram negative bacterial infection comprises a cationic antimicrobial protein (CAP) in conjunction with a compound of formula I.

IPC Classes  ?

• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• C07C 235/42 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
• C07C 235/44 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
• C07C 235/48 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Abstract

1221222-SH ligand is attached. The alkyl group may be ethyl or propyl. The chemical compound may be used to complex cation lead or mercury, in which the cation is complexed with mercapto-sulfur of the thio-sulfonyl moiety and the terminal mercaptan to form a heterocyclic ring-like geometry incorporating the cation. A method for removing cations from a liquid stream using the chemical compounds of the present invention is also provided.

IPC Classes  ?

• B01J 39/16 - Organic material
• B01J 45/00 - Ion-exchange in which a complex or a chelate is formedUse of material as complex or chelate forming ion-exchangersTreatment of material for improving the complex or chelate forming ion-exchange properties
• C07C 309/02 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms
• C07C 321/04 - Thiols having mercapto groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton

Abstract

2—SH ligand is attached. The alkyl group may be ethyl or propyl. The chemical compound may be used to complex cation lead or mercury, in which the cation is complexed with mercapto-sulfur of the thio-sulfonyl moiety and the terminal mercaptan to form a heterocyclic ring-like geometry incorporating the cation. A method for removing cations from a liquid stream using the chemical compounds of the present invention is also provided.

IPC Classes  ?

• B01J 39/20 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
• C08F 212/36 - Divinylbenzene
• C08F 212/08 - Styrene
• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
• C08F 8/34 - Introducing sulfur atoms or sulfur-containing groups

Abstract

A thin film composite (TFC) forward osmosis (FO) membrane includes a porous support with surfaces having thereon a hydrophilic self-assembled monolayer. An active layer on the support is sufficiently dense to remove an ionic species from a liquid.

IPC Classes  ?

• B01D 69/10 - Supported membranesMembrane supports
• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01D 71/56 - Polyamides, e.g. polyester-amides
• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/80 - Block polymers
• C08J 9/42 - Impregnation with macromolecular compounds
• B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor

Abstract

A thin film composite (TFC) forward osmosis (FO) membrane includes a porous support with surfaces having thereon a hydrophilic self-assembled monolayer. An active layer on the support is sufficiently dense to remove an ionic species from a liquid.

IPC Classes  ?

• B01D 71/06 - Organic material
• B01D 71/80 - Block polymers
• B05D 1/18 - Processes for applying liquids or other fluent materials performed by dipping
• C08J 9/42 - Impregnation with macromolecular compounds

Abstract

A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
• A61K 9/51 - Nanocapsules
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• A61K 49/04 - X-ray contrast preparations
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B01J 13/02 - Making microcapsules or microballoons
• C09B 67/02 - Dyestuff preparations characterised by special physical forms, e.g. tablets, films
• C09B 67/08 - Coated particulate pigments or dyes
• C09B 67/00 - Influencing the physical, e.g. the dyeing or printing, properties of dyestuffs without chemical reaction, e.g. by treating with solventsProcess features in the making of dyestuff preparationsDyestuff preparations of a special physical nature, e.g. tablets, films
• C09B 47/00 - PorphinesAzaporphines
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

In alternative embodiments, the invention provides compositions, or products of manufacture, comprising a titanium dioxide surface layer that is free, or substantially free, of nickel. In alternative embodiments, the invention also provides methods of making and using these compositions or products of manufacture. In alternative embodiments, the compositions or products of manufacture of the invention are biomedical devices or implants or prostheses.

IPC Classes  ?

• C01G 23/047 - Titanium dioxide
• C01G 23/08 - DryingCalcining
• C01B 21/076 - Binary compounds of nitrogen with metals, with silicon, or with boron with titanium or zirconium

Abstract

A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 47/02 - Inorganic compounds
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 49/00 - Preparations for testing in vivo
• B01J 13/08 - Simple coacervation, i.e. addition of highly hydrophilic material
• C08J 3/14 - Powdering or granulating by precipitation from solutions
• C08J 7/06 - Coating with compositions not containing macromolecular substances

Abstract

A method for the cleanup of ionic species such as cobalt and nickel in nuclear power plant aqueous streams using a sequestration resin material is disclosed herein. The method includes the steps of providing a sequestration resin for removal of radioisotopes of transition metal impurities contained in the plant process streams, and distributing the sequestration resin into the plant process streams such that the sequestration resin interacts with the process streams and removes the transition metal impurities.

IPC Classes  ?

• G21F 9/12 - Processing by absorptionProcessing by adsorptionProcessing by ion-exchange
• B01J 45/00 - Ion-exchange in which a complex or a chelate is formedUse of material as complex or chelate forming ion-exchangersTreatment of material for improving the complex or chelate forming ion-exchange properties

Abstract

The present invention relates to a method of capturing radioactive species in an aqueous solution and removing the radioactive species for disposal. The method includes the steps of providing a macroporous bead form sequestration resin including a sequestration ligand coupled to a sulfonic acid based polymer resin, subjecting the bead form sequestration resin to radioactive species contained in the aqueous solution to allow the bead form sequestration resin to capture the radioactive species; using an acid to lower a pH of the resin to release the radioactive species; and disposing the radioactive species in a radioactive storage facility.

IPC Classes  ?

• G21F 1/00 - Shielding characterised by the composition of the material
• G21F 9/12 - Processing by absorptionProcessing by adsorptionProcessing by ion-exchange
• B01J 39/04 - Processes using organic exchangers
• B01J 39/16 - Organic material
• B01J 45/00 - Ion-exchange in which a complex or a chelate is formedUse of material as complex or chelate forming ion-exchangersTreatment of material for improving the complex or chelate forming ion-exchange properties

Abstract

An organic synthesis of materials to achieve removal of low molecular weight ionic species, such as transition metal ions including cobalt, iron, nickel, and zinc, from aqueous solutions. The synthesis includes the steps of providing a cation exchange resin, functionalizing the cation exchange resin using a chloride intermediate to form a sulfonyl chloride resin, and reacting a multi-amine based ligand with the sulfonyl chloride resin to form a sequestration resin. The synthesis further includes the steps of cooling the sequestration resin, and washing and drying the sequestration resin.

IPC Classes  ?

• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
• B01J 39/04 - Processes using organic exchangers
• B01J 39/18 - Macromolecular compounds
• B01J 45/00 - Ion-exchange in which a complex or a chelate is formedUse of material as complex or chelate forming ion-exchangersTreatment of material for improving the complex or chelate forming ion-exchange properties
• G21F 9/12 - Processing by absorptionProcessing by adsorptionProcessing by ion-exchange
• B01J 20/32 - Impregnating or coating
• C02F 101/00 - Nature of the contaminant
• C02F 101/20 - Heavy metals or heavy metal compounds
• C02F 103/34 - Nature of the water, waste water, sewage or sludge to be treated from the chemical industry not provided for in groups