A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
B67D 7/38 - Arrangements of hoses, e.g. operative connection with pump motor
A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.
B65D 41/00 - Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
B25G 1/10 - Handle constructions characterised by material or shape
B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
B33Y 80/00 - Products made by additive manufacturing
F16J 15/02 - Sealings between relatively-stationary surfaces
3.
TUBE HOLDING APPARATUSES FOR FILLING OF MULTIPLE CONTAINERS AND METHODS FOR USING THE SAME
A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.
A tube holding apparatus includes a body, a mount a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
C12M 1/00 - Apparatus for enzymology or microbiology
5.
TUBE HOLDING APPARATUSES FOR FILLING OF MULTIPLE CONTAINERS AND METHODS FOR USING THE SAME
A tube holding apparatus includes a body, a mount, a first guide, and a second guide. The body has a proximal end portion and a distal end portion. The mount is positioned between the proximal end portion and the distal end portion of the body. The mount is configured to secure the body to a valve tower. The first guide is secured about the proximal end portion of the body. The second guide is secured about the distal end portion of the body. The first guide and the second guide each configured to receive a portion of a transfer link that extends between a valve tower and a storage container such that a positive slope container to the valve tower.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Microcarriers for use in manufacturing, laboratory use, and research use; protein-coated microcarrier beads for use in manufacturing, laboratory use, and research use; non-protein coated microcarrier beads for use in manufacturing, laboratory use, and research use; microcarriers for use in preparing cell cultures and in cell culture applications; kits consisting of microcarriers for use in manufacturing, laboratory use, and research use; sterilized bags containing microcarriers for use in manufacturing, laboratory use, and research use
7.
VALVE SWITCHING SYSTEM FOR SELECTIVELY INTERCONNECTING COMPONENTS OF A BIOPROCESS INSTALLATION
Various embodiments are directed to a valve switching system for selectively interconnecting components of a bioprocess installation, comprising a valve switching cassette and an actuator block. It is proposed, that the valve switching cassette comprises a perforated backer plate securing a valve membrane structure to a cassette manifold, that the actuator block comprises a drive membrane structure with at least one drive membrane and a perforated backer plate securing the drive membrane structure to an actuator block body, wherein for selectively switching valve units, an actuator of the actuator block may urge the drive membrane structure through aligned perforation holes of both backer plates into engagement with the valve membrane structure.
x,yx,yx,y), an actuator of the actuator block (16) may urge the drive membrane structure (23) through aligned perforation holes (25, 26) of both backer plates (22, 24) into engagement with the valve membrane structure (20).
A method of molding an article includes positioning a dissolvable insert within a mold, filling the mold with material to form an article within the mold and about the dissolvable insert, and at least partially dissolving the dissolvable insert from within the article. The dissolvable insert forms internal features of the article and includes a porous core.
B29C 45/44 - Removing or ejecting moulded articles for undercut articles
B29C 33/52 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles soluble or fusible
The invention relates to a continuous flow centrifuge (1) comprising a rotor (6). The continuous flow centrifuge (1) comprises a connecting strand (12) having connection lines (16, 17), via which an exchange of media in containers (8a, 8b) arranged in the centrifugation chambers of the rotor (6) is possible. According to the invention, a temperature-control supply line (14) and a temperature-control discharge line (16) for a connecting strand temperature-control fluid extends through the connecting strand (12) in order to counteract a heating of the connecting strand (12) due to flexing and friction occurring therein. The connecting strand temperature-control fluid flows through the temperature-control supply line (14) and the temperature-control discharge line (15) in opposing flow directions. An electronic control unit (28) has a control logic which controls the connecting strand temperature-control power of a connecting strand temperature-control circuit (36) in an open-loop or closed-loop manner.
The invention relates to a continuous-flow centrifuge comprising a rotor which has at least one centrifugation chamber and rotates about a rotor axis (7) at a rotor speed. The continuous-flow centrifuge comprises a connecting strand (12) through which connecting lines (16, 17) extend. A medium can be supplied to the centrifugation chamber, and the medium can be discharged from the centrifugation chamber, via the connecting lines (16, 17) during operation of the continuous-flow centrifuge with the rotor rotating. One end region (18) of the connecting strand (12) is fixed to the housing, whereas the other end region (19) of the connecting strand (12) rotates with the rotor. To prevent the connecting strand (12) from twisting, the connecting strand (12) is guided in a compensation-rotor guide device (20) (in particular a guide tube (21)) which rotates about the rotor axis (7) at half the rotor speed. According to the invention, the compensation-rotor guide device (20) has a guide contour (27), the radius of curvature (32) of which is greater in a first guide-contour section (28) than the radius of curvature (33) in a second guide-contour section (29). As a result, the service life of the connecting strand (12) can be increased.
A tilting mechanism including a base, a tilting deck, four hinges, and a lifting member. Each hinge is positioned adjacent a corner of the base and the tilting deck. Each hinge includes a globe and a receiver with the globe or the receiver secured to the base frame or the deck frame and the other secured to the other of the base or the tilting deck. Each hinge includes a locking member that selectively secures a globe within a respective receiver. The lifting member is secured at a center of the base frame and a center of the deck frame. The lifting member is configured to urge the tilting deck away from the base such that selective engagement allows for tilting of the tilting deck relative to the base in at least four directions.
B62B 3/08 - Hand carts having more than one axis carrying transport wheels; Steering devices therefor; Equipment therefor involving tiltably-mounted containers
B62B 3/02 - Hand carts having more than one axis carrying transport wheels; Steering devices therefor; Equipment therefor involving parts being adjustable, collapsible, attachable, detachable, or convertible
B67D 7/84 - Casings, cabinets or frameworks; Trolleys or like movable supports
A tilting mechanism including a base, a tilting deck, four hinges, and a lifting member. Each hinge is positioned adjacent a corner of the base and the tilting deck. Each hinge includes a globe and a receiver with the globe or the receiver secured to the base frame or the deck frame and the other secured to the other of the base or the tilting deck. Each hinge includes a locking member that selectively secures a globe within a respective receiver. The lifting member is secured at a center of the base frame and a center of the deck frame. The lifting member is configured to urge the tilting deck away from the base such that selective engagement allows for tilting of the tilting deck relative to the base in at least four directions.
B60P 1/16 - Vehicles predominantly for transporting loads and modified to facilitate loading, consolidating the load, or unloading with a tipping movement of load supporting or containing element actuated by fluid-operated mechanisms
E05D 15/50 - Suspension arrangements for wings allowing alternative movements for opening at either of two opposite edges
B62B 3/08 - Hand carts having more than one axis carrying transport wheels; Steering devices therefor; Equipment therefor involving tiltably-mounted containers
14.
SMALL VOLUME SYSTEM AND METHODS OF EVALUATING THE STABILITY OF BIOPHARMACEUTICAL COMPOSITIONS
An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.
An analysis container includes an outer tube and a plurality of inner tubes. The outer tube defines a buffer volume that is configured to receive a buffer material. The plurality of inner tubes is disposed within the buffer volume. Each inner tube has an inner diameter equal to or less than 6 mm and is configured to receive a biopharmaceutical composition therein. The outer tube is configured such that the buffer material and the biopharmaceutical composition are axially frozen.
An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.
F16L 3/22 - Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets specially adapted for supporting a number of parallel pipes at intervals
F16L 3/02 - Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets partly surrounding the pipes, cables or protective tubing
A clamp for closing a flexible tube includes an anvil and a hammer. The anvil includes a passage and a slot defined therein. The passage is configured to receive a flexible tube therethrough. The hammer is slidably received within the slot of the anvil. The hammer is securable in a first position in which the passage of the anvil is substantially unoccluded and a second position in which the passage of the anvil is occluded. The hammer and the anvil are configured to prevent fluid from flowing through the flexible tube received in the passage when the hammer is in the closed position. The hammer is substantially within the anvil in the closed position.
F16K 7/06 - Diaphragm cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage with tubular diaphragm constrictable by external radial force by means of a screw-spindle, cam, or other mechanical means
A61M 39/28 - Clamping means for squeezing flexible tubes, e.g. roller clamps
18.
SEMI-RIGID BIOCONTAINER AND METHODS OF MANUFACTURING THE SAME
A biocontainer including a rigid frame and a flexible membrane. The frame includes a lattice core. The membrane may flex to adjust to a volume of biomaterial sealed within the interior of the biocontainer as a temperature of the biomaterial changes.
A biocontainer including a rigid frame and a flexible membrane. The frame includes a lattice core. The membrane may flex to adjust to a volume of biomaterial sealed within the interior of the biocontainer as a temperature of the biomaterial changes.
The invention is directed to a valve switching system for selectively interconnecting components of a bioprocess installation (2), comprising a valve switching cassette (15) and an actuator block (16). It is proposed, that the valve switching cassette (15) comprises a perforated sandwich plate (22) with perforation holes (23), which sandwich plate (22) is placed between the cassette manifold (17) and the actuator block body (21).
A valve switching cassette for selectively interconnecting components of a bioprocess installation, wherein the valve switching cassette comprises at least one fluid flow system of ports and fluid lines, which fluid flow system includes primary ports, communicating with primary fluid lines, and secondary ports, communicating with secondary fluid lines, wherein the valve switching cassette comprises an array of switchable valve units for selectively interconnecting the primary fluid lines with the secondary fluid lines via transfer fluid lines. It is prosed, that the valve switching cassette comprises a transfer plate with apertures and an elastically deformable membrane structure on each flat side of the transfer plate, that at least part of the primary fluid lines and secondary fluid lines are extending between the transfer plate and one of the membrane structures and that the transfer fluid lines are at least partly provided by the apertures.
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
22.
VALVE SWITCHING CASSETTE FOR SELECTIVELY INTERCONNECTING COMPONENTS OF A BIOPROCESS INSTALLATION
ppssx,ypspss) are extending between the transfer plate (17) and one of the membrane structures (19, 20) and that the transfer fluid lines (T) are at least partly provided by the apertures (18).
06 - Common metals and ores; objects made of metal
07 - Machines and machine tools
08 - Hand tools and implements
20 - Furniture and decorative products
Goods & Services
Metal collars for aseptic disconnection of laboratory tubing; aluminum collars for aseptic disconnection of laboratory tubing; sealing caps of metal for aseptic disconnection of laboratory tubing; sealing caps of metal for aseptic disconnection of laboratory tubing for use in the food and beverage, pharmaceutical, and biopharmaceutical industries Power tools, namely, laboratory cutting tools for tubing separation and creation of aseptic seals; power-operated cutting tools for metal collars and laboratory tubing; power-operated tools, namely, cutting tools for tubing separation; battery-operated cutting tools for metal collars and laboratory tubing; battery-operated tools, namely, cutting tools for tubing separation Hand tools, namely, laboratory cutting tools for tubing separation and creation of aseptic seals; hand-operated cutting tools for metal collars and laboratory tubing; hand-operated tools, namely, cutting tools for tubing separation Non-metallic sealing caps for laboratory tubing; non-metallic protective caps for use in the food and beverage, pharmaceutical, and biopharmaceutical industries, namely, for use on laboratory tubing and metal collars; silicone protective caps in the nature of sealing caps for metal collars and laboratory tubing
The invention is directed to a method for operating a clarification setup (1) of a bioprocess installation (2), wherein the clarification setup (1) comprises a fluidized bed centrifuge (3) for the clarification of a cell broth by centrifugation, wherein the fluidized bed centrifuge (3) comprises at least two centrifuge chambers (9-12), wherein the fluidized bed centrifuge (3) is being operated in a forward operation for a particle loading cycle and/or a particle washing cycle and in a backward operation for a particle discharging cycle, wherein during the particle loading cycle, cell broth loaded into the centrifuge chamber (9-12) proceeds to form a growing particle accumulation in the centrifuge chamber (9-12), wherein the clarification setup (1) comprises a monitoring sensor arrangement (17) with at least one, preferably optical, sensor (18) for producing monitoring sensor data, which are being transmitted to the electronic process control (14). It is proposed that in a monitoring routine, for at least part of the centrifuge chambers (9-12), monitoring sensor data (19) are being produced individually by the monitoring sensor arrangement (17) and that during the loading cycle, in an adjusting routine, at least one parameter of the clarification setup (1) is being adjusted based on the monitoring sensor data (19) as to control the loading of the cell broth the centrifuge chambers (9-12) individually according to a predefined adjusting strategy.
The invention is directed to a method for operating a clarification setup (1) of a bioprocess installation (2), which clarification setup comprises a fluidized bed centrifuge (3) and a pumping arrangement (4), wherein the fluidized bed centrifuge (3) comprises at least one centrifuge chamber (5) turned around a geometrical centrifuge axis (6), wherein the bioprocess installation (2) comprises an electronic process control (7) for controlling the fluidized bed centrifuge (3) and pumping arrangement (4), wherein the fluidized bed centrifuge (3) is being operated in a forward operation for a particle loading cycle (8) and/or a particle washing cycle (9) and in a backward operation for a particle discharging cycle (10), wherein in case where a particle loading cycle (8) is provided, cell broth loaded into the centrifuge chamber (5) proceeds to form a growing particle accumulation in the centrifuge chamber (5), wherein the clarification setup (1) comprises a monitoring sensor arrangement (11) with at least one optical sensor (12) for producing monitoring sensor data, which are being transmitted to the electronic process control (7). It is proposed that in a monitoring routine (13), image-related data (14) representing an optical image (15) of the centrifuge chamber content (16) are being produced by the monitoring sensor arrangement (11) and a particle filling level (17) is being calculated by the electronic process control (7) from the image-related data (14) based on a calculation model (18).
A fluid distribution system includes an input tube, a plurality of vessels, and a distribution hub. The input tube is configured to extend from a supply vessel. Each vessel of the plurality of vessels includes an inflow conduit. The distribution hub includes a single inlet and a plurality of outlets. The single inlet is defined in a bottom of the distribution hub and is in fluid communication with the input tube such that the distribution hub is configured to receive fluid from the input tube through the single inlet. Each outlet of the plurality of outlets is in fluid communication with the single inlet and in fluid communication with a respective inflow conduit such that the distribution hub is configured to provide an equal portion of the fluid received through the single inlet to each of the inflow conduits.
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.
An organizer assembly including a belt and a ribbon. The ribbon has a first clamp member, a second clamp member, and a first carrier portion. The first clamp member is configured to receive a conduit or a support to fix the conduit or the support relative to the ribbon. The belt includes an elongated body that is slidably received in the first carrier portion. The organizer assembly may include one or more adapters that are received in a respective clamp member of the ribbon and configured to receive a conduit or a support to fix the conduit or support relative to the ribbon.
F16L 3/22 - Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets specially adapted for supporting a number of parallel pipes at intervals
F16L 3/02 - Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets partly surrounding the pipes, cables or protective tubing
29.
Thermal Capacitors, Systems, and Methods for Rapid Freezing or Heating of Biological Materials
A thermal capacitor includes a shell and a PCM. The shell includes a first major surface that is configured to contact a container including media to be frozen. The shell defines a cavity in which the PCM is disposed. The PCM has a transition temperature in a range of −80 degrees Celsius to −50 degrees Celsius and is configured to rapidly freeze media from room temperature to −60 degrees Celsius with the container including the media in contact with the shell in an enclosed space.
A thermal capacitor (100) includes a shell (110) and a PCM (150). The shell includes a first major surface (113, 117) that is configured to contact a container including media to be frozen. The shell defines a cavity (140) in which the PCM is disposed. The PCM has a transition temperature in a range of -80 degrees Celsius to -50 degrees Celsius and is configured to rapidly freeze media from room temperature to -60 degrees Celsius. Also disclosed are a rapid freezing system comprising a ULT Freezer and such a thermal capacitor, and a rapid freezing system comprising a rack and a plurality of such thermal capacitors. Further disclosed is a method of rapidly freezing media, comprising charging a plurality of such thermal capacitors disposed within a ULT Freezer, and placing a plurality of media containers in contact with at least one of the plurality of thermal capacitors.
A carrier for receiving a vessel includes a body that defines a well. The well is sized and dimensioned to receive a vessel including media. The body is configured to urge the vessel received in the well towards an external wall of the body to enhance thermal energy transfer into or out of the media within the vessel. A box assembly for supporting media during thermal changes includes a box, a vessel, and a carrier is also disclosed.
A carrier for receiving a vessel includes a body that defines a well sized and dimensioned to receive the vessel. A box assembly for supporting media during thermal changes is also disclosed, which includes a box (310) having a fixed wall assembly (320), a vessel (20), and a carrier (304), and wherein the carrier urges the vessel towards a thermal transfer wall (322) of the fixed wall assembly. The carrier may include a thermal energy transfer element to enhance thermal energy transfer into and out of the vessel. Also disclosed are a fluid distribution system comprising a fluid distribution hub; a frame supporting the fluid distribution hub and including an upper support; a plurality of carriers supported about the fluid distribution hub on the upper support; and a plurality of vessels. Further disclosed is a method of rapidly freezing media.
A fluid connector includes a body that has a first end and a second end. The first end defines a first opening that has a first diameter and the second end defines a second opening that has a second diameter different from the first diameter. The body has an inner surface defining a channel that extends from the first opening to the second opening. The inner surface smoothly extending from the first end to the second end. The first connector configured to prevent foaming of media flowed therethrough as a flow diameter of the media transition from the first diameter to the second diameter.
Method for the forming of a fluid-tight separating closure of a conduit (1) involving the following steps:
providing of a conduit (1) with a sleeve (2),
positioning of the conduit (1) with the sleeve (2) between a die (3) and a stamp (4),
compressing of the sleeve (2) by a relative movement between the die (3) and the stamp (4) in order to form a closure (5);
severing of the closure (5) in a compressed region (6) by a severing tool (7) such that a contact line (8) between the severing tool (7) and the sleeve (2) during severing is shorter than an obtained severing edge (9) of the sleeve (2).
A fluid connector includes a body that has a first end and a second end. The first end defines a first opening that has a first diameter and the second end defines a second opening that has a second diameter different from the first diameter. The body has an inner surface defining a channel that extends from the first opening to the second opening. The inner surface smoothly extending from the first end to the second end. The first connector configured to prevent foaming of media flowed therethrough as a flow diameter of the media transition from the first diameter to the second diameter.
F16L 33/213 - Undivided rings, sleeves, or like members contracted on the hose or expanded inside the hose by means of tools; Arrangements using such members only a sleeve being expanded inside the hose
B67D 7/38 - Arrangements of hoses, e.g. operative connection with pump motor
06 - Common metals and ores; objects made of metal
07 - Machines and machine tools
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
11 - Environmental control apparatus
12 - Land, air and water vehicles; parts of land vehicles
20 - Furniture and decorative products
Goods & Services
(1) Containers, and transportation and packaging articles, of metal; metal containers for holding and transporting flexible pouches for biological, medical or pharmaceutical liquids; Containers of metal [storage, transport]; Metal pallets; Metal racks for storage of containers filled with biopharmaceutical materials; Metallic frames for supporting disposable containers for biopharmaceutical materials
(2) Mixing machines; Mixing machines for mixing and homogenizing liquids in the pharmaceutical and chemical industries; Lifting apparatus; Packaging machines, namely, liquid container fillers; Filling machines; Machines for filling containers in the nature of disposable plastic bags with biopharmaceutical liquids; Dispensing machines; Dispensing machines for emptying containers filled with biopharmaceutical liquids; Control devices for machines
(3) Measuring apparatus and instruments; controllers and regulators; Sensors and detectors; Electrical controllers; Temperature control apparatus for chilling biopharmaceutical materials in disposable containers; Temperature controllers for controlling the temperature of biopharmaceutical materials held in disposable containers designed for cryopreservation; Disposable containers for cryopreservation of biopharmaceutical materials, Protective devices and frames for use with disposable containers for biopharmaceutical materials; Apparatus for mixing biopharmaceutical media, in particular by vibration, rotation and wave motion; Weighing apparatus and instruments and parts therefor; weighing apparatus for weighing the amount of liquids filled into and dispensed from disposable containers; Automated liquid dispensing machines; Dosage dispensers, Liquid dosage devices that measure the amounts to be dispensed
(4) Disposable containers specially designed for cryopreserving biopharmaceutical materials; protective rigid housing structures for receiving disposable containers for cryopreserving biopharmaceutical materials; frames for supporting disposable containers for cryopreserving biopharmaceutical materials; storage units and transportation carts for disposable containers for cryopreserving biopharmaceutical materials; Protective devices in the nature of sleeves and frames for disposable containers for the low temperature control of biopharmaceutical materials for medical use
(5) Refrigerating and freezing equipment; Refrigerators, cooling apparatus and freezers for medical storage purposes; Refrigerating containers; Refrigerated shipping containers; Temperature controlled shipping containers; Refrigerated medical container for storage, transportation and cooling of medicines and pharmaceuticals; Freezing installations and machines for freezing biopharmaceutical materials; Laboratory freezers for cryogenic preservation; Heaters and heating systems for thawing frozen biopharmaceutical materials; Cooling and heating systems for processing biopharmaceutical materials; Containers equipped with temperature controllers for biopharmaceutical materials
(6) Transportation carts for disposable containers for cryopreserving biopharmaceutical materials; Electric lift trucks; Mobile fork lifts
(7) Insulated containers for the transport and storage of temperature sensitive goods; Thermal insulation covers for storage or transportation of biopharmaceutical materials
(8) Containers, and closures and holders therefor, non-metallic; Containers, not of metal, for storage or transport; Containers for biopharmaceutical liquids, non-metallic; Packaging containers of plastic; Non-metal and non-paper insulated shipping containers for transporting frozen materials; Plastic shipping and storage boxes; crates and pallets, non-metallic; Disposable containers made of plastic for storage and transport of frozen biopharmaceutical materials; protective rigid housing structures made of plastic for receiving disposable containers for biopharmaceutical materials, Non-metallic frames for supporting disposable containers for biopharmaceutical materials; Sample bag cover specifically adapted to disposable containers for biopharmaceutical materials
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
07 - Machines and machine tools
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Packaging machines, namely, liquid container fillers; Filling machines; Machines for filling containers with biopharmaceutical liquids; Dispensing machines; Dispensing machines for emptying containers filled with biopharmaceutical liquids; Machines for filling and emptying disposable plastic bags with biopharmaceutical liquids; Fluid pumps; Pump control valves; Control devices for machines
(2) Measuring apparatus and instruments; controllers and regulators; Sensors and detectors; Automatic control apparatus; Programmable control apparatus; Automatic control apparatus for controlling filling and dispensing machines; Automatic liquid-flow control machines and instruments; Automatic liquid-flow control machines and instruments Measuring and control devices for processing biopharmaceutical liquids; Automatic control valves; Control valves for regulating the flow of biopharmaceutical liquids; Automatic control valves for controlling the flow of biopharmaceutical liquids into and out of disposable containers; Weighing apparatus and instruments and parts therefor; weighing apparatus for weighing the amount of biopharmaceutical liquids filled into and dispensed from disposable containers; Automated liquid dispensing machines; Dosage dispensers, Liquid dosage devices that measure the amounts to be dispensed; Software for monitoring, analysing, controlling and running physical world operations; Machine control software; Process controlling software; Software for controlling and operating machines for packaging and dispensing biopharmaceutical liquids
38.
QUICK DISSOLVING CAVITY FORMING STRUCTURE FOR INJECTION MOLDED STRUCTURES
A method of molding an article includes positioning a dissolvable insert within a mold, filling the mold with material to form an article within the mold and about the dissolvable insert, and at least partially dissolving the dissolvable insert from within the article. The dissolvable insert forms internal features of the article and includes a porous core.
B29C 67/00 - Shaping techniques not covered by groups , or
C04B 35/44 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on aluminates
A clamp for closing a flexible tube includes an anvil and a hammer. The anvil includes a passage and a slot defined therein. The passage is configured to receive a flexible tube therethrough. The hammer is slidably received within the slot of the anvil. The hammer is securable in a first position in which the passage of the anvil is substantially unoccluded and a second position in which the passage of the anvil is occluded. The hammer and the anvil are configured to prevent fluid from flowing through the flexible tube received in the passage when the hammer is in the closed position. The hammer is substantially within the anvil in the closed position.
Disclosed is a system for freezing, storing, transporting, and thawing biopharmaceutical product, comprising a stationary equipment and one or more movable pallets, each pallet configured to carry one or more container units, each containing biopharmaceutical product, the stationary equipment comprising a gas circulating unit configured to cause a circulation of cold gas and/or warm gas, from a pull inlet toward a blow outlet, wherein there is provided at least a first side plenum having one or more gas conveying channel therein, configured to be fluidly coupled to the blow outlet of the gas circulating unit, the first side plenum having a plurality of outlet ports directed toward an interior volume of the pallet, wherein the gas circulates substantially in a horizontal direction in the interior volume of the pallet, and wherein a shaking arrangement is provided.
B01F 31/20 - Mixing the contents of independent containers, e.g. test tubes
B65D 19/00 - Pallets or like platforms, with or without side walls, for supporting loads to be lifted or lowered
F25D 17/06 - Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection by forced circulation
F25D 25/00 - Charging, supporting, or discharging the articles to be cooled
06 - Common metals and ores; objects made of metal
07 - Machines and machine tools
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
12 - Land, air and water vehicles; parts of land vehicles
20 - Furniture and decorative products
Goods & Services
Metal pallets; Metal racks for storage of containers filled with biopharmaceutical materials; Metallic frames for supporting disposable containers for biopharmaceutical materials. Lifting apparatus. Frames for use with disposable containers for biopharmaceutical materials, the aforementioned goods for pharmaceutical purposes; Weighing apparatus and instruments and parts therefor; Weighing apparatus for weighing the amount of liquids filled into and dispensed from disposable containers. Protective rigid housing structures for receiving disposable containers for cryopreserving biopharmaceutical materials; Frames for supporting disposable containers for cryopreserving biopharmaceutical materials; Protective rigid housing structures made of plastic for receiving disposable containers for biopharmaceutical materials, non-metallic frames for supporting disposable containers for biopharmaceutical materials. Transportation carts for disposable containers for cryopreserving biopharmaceutical materials; Electric lift trucks; Mobile fork lifts. Holders therefor (containers), non-metallic; pallets, non-metallic.
06 - Common metals and ores; objects made of metal
07 - Machines and machine tools
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
11 - Environmental control apparatus
12 - Land, air and water vehicles; parts of land vehicles
16 - Paper, cardboard and goods made from these materials
17 - Rubber and plastic; packing and insulating materials
20 - Furniture and decorative products
Goods & Services
Containers of metal for chemicals and liquids; shipping containers of metal; packaging articles, of metal for transport and storage of goods; metal containers for holding and transporting flexible pouches for biological, medical or pharmaceutical liquids; Containers of metal for storage and transport of goods; Metal pallets; Metal racks for storage of containers filled with biopharmaceutical materials; Metallic frames for supporting disposable containers for biopharmaceutical materials Mixing machines; Mixing machines for mixing and homogenizing liquids in the pharmaceutical and chemical industries; power-operated lifting apparatus for the transport of goods, power-operated fork lifters; Packaging machines, namely, liquid container fillers; Filling machines; Machines for filling containers in the nature of disposable plastic bags with biopharmaceutical liquids; biopharmaceutical liquid dispensing machines for industrial use; Dispensing machines for emptying containers filled with biopharmaceutical liquids; pneumatic controls for machines; hydraulic controls for machines Liquid flow measuring apparatus and instruments; electrical controllers and flow regulators for industrial use; electric sensors and detectors; electrical controllers; Temperature control apparatus for chilling biopharmaceutical materials in disposable containers; Temperature controllers for controlling the temperature of biopharmaceutical materials held in disposable containers designed for cryopreservation; scientific apparatus for mixing biopharmaceutical media, in particular by vibration, rotation and wave motion; Weighing apparatus and instruments and structural parts therefor; weighing apparatus for weighing the amount of liquids filled into and dispensed from disposable containers; scientific apparatus, namely, automated liquid dispensing machines for dispensing pharmaceutical solutions; Dosage dispensers, Liquid dosage devices that measure the amounts to be dispensed Disposable containers especially made for cryopreserving biopharmaceutical materials; protective rigid housing structures for receiving disposable containers for cryopreserving biopharmaceutical materials and used as a structural component thereof; frames for supporting disposable containers for cryopreserving biopharmaceutical materials and used as a structural component thereof; storage units and transportation carts specially designed for disposable containers for cryopreserving biopharmaceutical materials; Protective devices in the nature of sleeves and frames specially designed for disposable containers for the low temperature control of biopharmaceutical materials for medical use; Disposable containers specially designed for cryopreservation of biopharmaceutical materials; Protective devices and frames for use as an integral component to secure and store disposable containers for biopharmaceutical materials Refrigerating and freezing equipment in the nature of refrigerating machines and freezers; Refrigerators, cooling apparatus and freezers for medical storage purposes; Refrigerating containers; Refrigerated shipping containers; Temperature controlled shipping containers; Refrigerated medical container for storage, transportation and cooling of medicines and pharmaceuticals; Freezing installations and machines for freezing biopharmaceutical materials; Laboratory freezers for cryogenic preservation; Heaters and heating systems comprised of heat generators for thawing frozen biopharmaceutical materials; Cooling and heating systems comprised of electric coolers and heat generators for processing biopharmaceutical materials; Containers equipped with temperature controllers for biopharmaceutical materials Transportation carts for disposable containers for cryopreserving biopharmaceutical materials; Electric lift trucks; Mobile fork lift trucks Insulated containers of cardboard for the transport and storage of temperature sensitive goods Thermal insulation covers for storage or transportation of biopharmaceutical materials Containers, and closures and holders therefor, non-metallic and non-paper; Containers, not of metal or paper, for storage or transport; Containers for biopharmaceutical liquids, non-metallic and non-paper; Packaging containers of plastic; Non-metal and non-paper insulated shipping containers for transporting frozen materials; Plastic shipping and storage boxes; crates and pallets, non-metallic; Disposable containers made of plastic for storage and transport of frozen biopharmaceutical materials; protective rigid housing structures made of plastic for receiving disposable containers for biopharmaceutical materials, Non-metallic frames for supporting disposable containers for biopharmaceutical materials; Sample bag cover specifically adapted to disposable containers for biopharmaceutical materials
09 - Scientific and electric apparatus and instruments
Goods & Services
Packaging machines, namely, liquid container fillers; Filling machines; Machines for filling containers with biopharmaceutical liquids; Dispensing machines; Dispensing machines for emptying containers filled with biopharmaceutical liquids; Machines for filling and emptying disposable plastic bags with biopharmaceutical liquids; Fluid pumps; Pump control valves; Control devices for machines. Measuring apparatus and instruments; controllers and regulators; Sensors and detectors; Automatic control apparatus; Programmable control apparatus; Automatic control apparatus for controlling filling and dispensing machines; Automatic liquid-flow control machines and instruments; Automatic liquid-flow control machines and instruments Measuring and control devices for processing biopharmaceutical liquids; Automatic control valves; Control valves for regulating the flow of biopharmaceutical liquids; Automatic control valves for controlling the flow of biopharmaceutical liquids into and out of disposable containers; Weighing apparatus and instruments and parts therefor; weighing apparatus for weighing the amount of biopharmaceutical liquids filled into and dispensed from disposable containers; Automated liquid dispensing machines; Dosage dispensers, Liquid dosage devices that measure the amounts to be dispensed; Software for monitoring, analysing, controlling and running physical world operations; Machine control software; Process controlling software; Software for controlling and operating machines for packaging and dispensing biopharmaceutical liquids.
09 - Scientific and electric apparatus and instruments
Goods & Services
packaging machines, namely, liquid container fillers; filling machines; machines for filling containers with biopharmaceutical liquids; biopharmaceutical liquid dispensing machines for industrial use; dispensing machines for emptying containers filled with biopharmaceutical liquids; machines for filling and emptying disposable plastic bags with biopharmaceutical liquids; electric fluid pumps; pump control valves; pneumatic controls for machines; hydraulic controls for machines measuring apparatus and instruments, namely, flowmeters; electronic controllers for the operation of liquid dispersing and filling machines; flow regulators for industrial use; electric sensors and detectors; liquid level sensors and detectors; pressure sensors and detectors; temperature sensors and detectors; sensors for measuring chemical level in aqueous solutions, not for medical use; automatic control apparatus in the nature of electrical controllers; programmable control apparatus in the nature of programmable logic controllers; automatic control apparatus in the nature of electronic controllers for operating and monitoring filling and dispensing machines; automatic liquid-flow control machines and instruments in the nature of electrical controllers; measuring and control devices for processing biopharmaceutical liquids; automatic control valves for regulating flow of liquids; control valves for regulating the flow of biopharmaceutical liquids; automatic control valves for controlling the flow of biopharmaceutical liquids into and out of disposable containers; weighing apparatus and instruments and structural parts therefor; weighing apparatus for weighing the amount of liquids filled into and dispensed from disposable containers; scientific apparatus, namely, automated liquid dispensing machines for dispensing pharmaceutical solutions; dosage dispensers, liquid dosage devices that measure the amounts to be dispensed; downloadable software for monitoring, analysing, controlling and running physical world operations; recorded software for monitoring, analysing, controlling and running physical world operations; downloadable machine control software; recorded machine control software; downloadable process controlling software; recorded process controlling software; downloadable software for controlling and operating machines for packaging and dispensing biopharmaceutical liquids; recorded software for controlling and operating machines for packaging and dispensing biopharmaceutical liquids
46.
Fluid Transfer Assembly, A Fluid Transfer System, and a Related Method
Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.
B29C 37/00 - Component parts, details, accessories or auxiliary operations, not covered by group or
B29C 33/50 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles with means for collapsing or disassembling elastic
B29C 65/70 - Joining of preformed parts; Apparatus therefor by moulding
B29C 39/10 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. casting around inserts or for coating articles
B29C 39/34 - Moulds or cores for undercut articles
FREEZE/THAW CONTAINMENT SYSTEM FOR FLEXIBLE POUCH FILLED WITH BIOPHARMACEUTICAL FLUID, AND METHOD OF ASSEMBLING A FREEZE/THAW CONTAINMENT SYSTEM, USING A PROTECTING BODY
A freeze/thaw containment system is provided, having a protecting body and a flexible pouch, of a first capacity, protected by two plates of the protecting body. The two plates are attached together at a peripheral margin and form a rectangular protecting body. The peripheral margin is mounted in a stationary frame and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar to sandwich and constrain the pouch. One amongst the stationary frame and the protecting body includes fastening members for attachment of a casing configured for storing the bag, in order to have the bag fastened parallel to the protecting body. Two fasteners for cooperating with the fastening members are distributed around a bag containing part of a second capacity at least ten times inferior to the first capacity. Same biopharmaceutical composition is contained in the pouch and in the bag.
B65D 77/06 - Liquids or semiliquids enclosed in flexible containers disposed within rigid containers
48.
Storage/containment unit for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body
A freeze/thaw containment system is provided, having a protecting body and a flexible pouch protected by two plates of the protecting body. The two plates are attached together at a peripheral margin and form a rectangular protecting body. The peripheral margin is mounted in supporting parts of a stationary frame and sliding positioning members are secured to the peripheral margin, so that the peripheral margin is guided and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar to sandwich and constrain the pouch in empty state of the pouch. This way of holding and retaining the protecting body allows for progressive conformational change of the protecting body due to the change in volume of the pouch when filled with a biopharmaceutical product, while facilitating reverse displacement of the peripheral margin during draining operations.
Storage/containment unit for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body
A protecting device is provided, having two plates forming a rectangular protecting body for sandwiching, constraining and protecting a flexible pouch. The two plates are attached together at a peripheral margin. Each plate has an outer surface with ribs provided in a peripheral annular region of a covering part receiving the pouch, along the peripheral margin. The peripheral margin is mounted in supporting parts of a frame and sliding positioning members may be secured to the peripheral margin, so that the peripheral margin is guided and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar, at least at panel parts surrounded by the ribs. This allows for progressive conformational change of the protecting body when filling the pouch with biopharmaceutical product, while facilitating reverse displacement of the peripheral margin during draining operations.
Freeze/thaw containment system for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body
A freeze/thaw containment system is provided, having a protecting body and a flexible pouch, of a first capacity, protected by two plates of the protecting body. The two plates are attached together at a peripheral margin and form a rectangular protecting body. The peripheral margin is mounted in a stationary frame and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar to sandwich and constrain the pouch. One amongst the stationary frame and the protecting body includes fastening members for attachment of a casing configured for storing the bag, in order to have the bag fastened parallel to the protecting body. Two fasteners for cooperating with the fastening members are distributed around a bag containing part of a second capacity at least ten times inferior to the first capacity. Same biopharmaceutical composition is contained in the pouch and in the bag.
STORAGE/CONTAINMENT UNIT FOR FLEXIBLE POUCH FILLED WITH BIOPHARMACEUTICAL FLUID, AND METHOD OF ASSEMBLING A FREEZE/THAW CONTAINMENT SYSTEM, USING A PROTECTING BODY
A freeze/thaw containment system is provided, having a protecting body and a flexible pouch protected by two plates of the protecting body. The two plates are attached together at a peripheral margin and form a rectangular protecting body. The peripheral margin is mounted in supporting parts of a stationary frame and sliding positioning members are secured to the peripheral margin, so that the peripheral margin is guided and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar to sandwich and constrain the pouch in empty state of the pouch. This way of holding and retaining the protecting body allows for progressive conformational change of the protecting body due to the change in volume of the pouch when filled with a biopharmaceutical product, while facilitating reverse displacement of the peripheral margin during draining operations.
B65D 77/06 - Liquids or semiliquids enclosed in flexible containers disposed within rigid containers
52.
STORAGE/CONTAINMENT UNIT FOR FLEXIBLE POUCH FILLED WITH BIOPHARMACEUTICAL FLUID, AND METHOD OF ASSEMBLING A FREEZE/THAW CONTAINMENT SYSTEM, USING A PROTECTING BODY
A protecting device is provided, having two plates forming a rectangular protecting body for sandwiching, constraining and protecting a flexible pouch. The two plates are attached together at a peripheral margin. Each plate has an outer surface with ribs provided in a peripheral annular region of a covering part receiving the pouch, along the peripheral margin. The peripheral margin is mounted in supporting parts of a frame and sliding positioning members may be secured to the peripheral margin, so that the peripheral margin is guided and allowed to be displaced inwardly during filling of the pouch, while the protecting body extends generally planar, at least at panel parts surrounded by the ribs. This allows for progressive conformational change of the protecting body when filling the pouch with biopharmaceutical product, while facilitating reverse displacement of the peripheral margin during draining operations.
B65D 77/06 - Liquids or semiliquids enclosed in flexible containers disposed within rigid containers
B65D 61/00 - External frames or supports adapted to be assembled around, or applied to, articles
B65D 81/05 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
53.
System for simultaneous distribution of fluid to multiple vessels and method of using the same
A method of aseptically distributing fluid including fluidly connecting a primary vessel to a fluid distribution system via a feedline of the supply vessel to form a closed system, priming the feedline to purge trapped gases and fluid from the feedline via a purge valve, simultaneously distributing fluid from the primary vessel to a plurality of secondary vessels, sensing a complete fill of the plurality of secondary vessels with the control system, and stopping the distribution of fluid when the complete fill is sensed by the control system.
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
B67D 7/38 - Arrangements of hoses, e.g. operative connection with pump motor
56.
STORAGE UNIT FOR USE IN FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIALS CONTAINED IN A FLEXIBLE POUCH AND A METHOD OF ASSEMBLING A PROTECTION SYSTEM FOR SUCH A STORAGE UNIT
A flexible pouch is placed in a stack provided with two plates forming a protecting body (12) to sandwich and constrain the pouch. At two opposite margin portions, the protecting body has slots (51, 52, 53) or interlocking members for cooperating with positioning members of an outer holding device (HR). Between lower and upper parts of the holding device, the two plates can move during filling of the pouch and the margin portions shrink inwardly in a protecting body plane. Some of the positioning members act as stoppers (41') to have lower clearance range for shrink strokes of the protecting body in a middle part thereof, as compared to a higher clearance range (X2) at respective longitudinal end parts of the margin portions. A higher constraining effect can be obtained in a center of the pouch, to limit maximum thickness of its content, which is of interest for managing freeze/thaw operations of biopharmaceutical content of the pouch.
B65D 77/06 - Liquids or semiliquids enclosed in flexible containers disposed within rigid containers
B65D 81/38 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
Storage/containement unit for flexible pouch filled with biopharmaceutical fluid, and method of assembling a freeze/thaw containment system, using a protecting body of controlled deformation
A flexible pouch is placed in a stack provided with two plates forming a protecting body to sandwich and constrain the flexible pouch. At opposite margin portions, the protecting body has slots cooperating with positioning members of an outer shell device belonging to the stack. Between the shell parts, the plates can move during filling of the pouch and the margin portions shrink inwardly in a protecting body plane. Some of the positioning members act as stoppers, in order to have lower clearance range for shrink strokes of the protecting body in a middle part thereof, as compared to a higher clearance range at respective longitudinal end parts of the two opposite margin portions. A higher constraining effect can be obtained in a center of the pouch, to limit maximum thickness of its content, which is of interest for managing freeze/thaw operations of biopharmaceutical materials contained in the pouch.
A connector for facilitating fluid transfer includes first fitting, a second fitting, a rigid conduit, a first retaining connector, and a second retaining connector. The rigid conduit includes a flexible tube surrounded by a deformable sleeve. The rigid conduit is connected on a first end to the first fitting and on a second end to the second fitting. The first retaining connector connects the first fitting to the rigid conduit and the second retaining connector connects the second fitting to the rigid conduit. A lumen extends through the rigid conduit and is capable of being sealed. The rigid conduit and the flexible tube are capable of being severed while maintaining the seal of the lumen to separate the first fitting from the second fitting. The connections of the first fitting and the second fitting to the rigid conduit are capable of withstanding at least 1 bar of pressure without leaking.
A connector for facilitating fluid transfer includes first fitting, a second fitting, a rigid conduit, a first retaining connector, and a second retaining connector. The rigid conduit includes a flexible tube surrounded by a deformable sleeve. The rigid conduit is connected on a first end to the first fitting and on a second end to the second fitting. The first retaining connector connects the first fitting to the rigid conduit and the second retaining connector connects the second fitting to the rigid conduit. A lumen extends through the rigid conduit and is capable of being sealed. The rigid conduit and the flexible tube are capable of being severed while maintaining the seal of the lumen to separate the first fitting from the second fitting. The connections of the first fitting and the second fitting to the rigid conduit are capable of withstanding at least 1 bar of pressure without leaking.
A fluid transfer assembly is described that includes a fitting comprising a lumen having an opening, and at least one barb, the at least one barb extending circumferentially around the lumen proximate to the opening. The assembly also includes a flexible conduit, a deformable sleeve, and an elastomeric liner disposed between the sleeve and the conduit. The fitting extends at least partially into the conduit such that the conduit extends over the at least one barb. The elastomeric liner applies substantially 360 degree radial pressure to the conduit such that the conduit is sealingly compressed around the at least one barb of the fitting. The assembly is fluid tight up to a burst pressure of the conduit.
F16L 13/16 - Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints made by plastically deforming the material of the pipe, e.g. by flanging, rolling the pipe joint consisting of overlapping extremities having mutually co-operating collars
F16L 13/14 - Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints made by plastically deforming the material of the pipe, e.g. by flanging, rolling
F16L 33/207 - Undivided rings, sleeves, or like members contracted on the hose or expanded inside the hose by means of tools; Arrangements using such members only a sleeve being contracted on the hose
61.
COMPOSITE ARTICLES OF LATTICE REINFORCED ELASTOMERS
A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.
B65D 41/00 - Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
B33Y 80/00 - Products made by additive manufacturing
A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.
B65D 41/00 - Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
B65D 55/00 - Accessories for container closures not otherwise provided for
F16J 15/02 - Sealings between relatively-stationary surfaces
F16J 15/10 - Sealings between relatively-stationary surfaces with solid packing compressed between sealing surfaces with non-metallic packing
B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
A flask stand is configured to support a flask and includes a base ring and a plurality of legs. The base ring is configured to support a lower portion of the flask. Each leg is secured to the base ring and extends outward from the base ring. Each leg includes a body, a lattice, and an elastomeric foot. The body includes a first end portion that is secured to the base ring with the foot portion being opposite the first end portion. The lattice is formed within the foot portion and includes a plurality of members that form an open-mesh frame that defines a plurality of voids between adjacent members of the frame. The elastomeric foot is formed of an elastomer and is disposed about the lattice and within the voids of the lattice. The foot is configured to engage a surface to support the body relative to the surface.
B29C 69/02 - Combinations of shaping techniques not provided for in a single one of main groups , e.g. associations of moulding and joining techniques; Apparatus therefor of moulding techniques only
B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
A flask stand is configured to support a flask and includes a base ring and a plurality of legs. The base ring is configured to support a lower portion of the flask. Each leg is secured to the base ring and extends outward from the base ring. Each leg includes a body, a lattice, and an elastomeric foot. The body includes a first end portion that is secured to the base ring with the foot portion being opposite the first end portion. The lattice is formed within the foot portion and includes a plurality of members that form an open-mesh frame that defines a plurality of voids between adjacent members of the frame. The elastomeric foot is formed of an elastomer and is disposed about the lattice and within the voids of the lattice. The foot is configured to engage a surface to support the body relative to the surface.
A fluid distribution system is configured to distribute fluid from a first vessel to second vessels includes a hub assembly and a frame assembly. The hub assembly has an input cap, a distribution cap, a first clamp, and a second clamp. The input cap defines an inlet and the distribution cap is sealingly secured to the input cap with a plenum being defined between the input and distribution caps. The distribution cap includes conduit connectors that each defines an outlet in fluid communication with the plenum. The first clamp is disposed over the distribution cap and is engaged with the input cap to secure the input cap to the distribution cap and the second clamp is disposed over the input cap and engaged with the distribution cap to secure the distribution cap to the input cap. The frame assembly supports the hub assembly and is configured to secure each of the secondary vessels at a predetermined distance relative to the hub assembly.
A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.
B65D 41/00 - Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
B33Y 80/00 - Products made by additive manufacturing
F16J 15/02 - Sealings between relatively-stationary surfaces
B25G 1/10 - Handle constructions characterised by material or shape
Method for the forming of a fluid-tight separating closure of a conduit (1) involving the following steps: - providing of a conduit (1) with a sleeve (2), - positioning of the conduit (1) with the sleeve (2) between a die (3) and a stamp (4), - compressing of the sleeve (2) by a relative movement between the die (3) and the stamp (4) in order to form a closure (5); - severing of the closure (5) in a compressed region (6) by a severing tool (7) such that a contact line (8) between the severing tool (7) and the sleeve (2) during severing is shorter than an obtained severing edge (9) of the sleeve (2).
A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.
Vessel closure assemblies are provided. The vessel closure assemblies may be engaged with vessels. The vessel closure assemblies may each include a vessel closure, inserts such as anchors and fluid conduits extending through the vessel closure, and a respiratory assembly. The respiratory assembly may include a housing and one or more gas permeable membranes. The gas permeable membranes may be oriented substantially perpendicular to a top wall of the vessel closure through which the inserts extend.
A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.
A bioreactor for culturing of microorganisms or cells comprising: a casing defining an interior space of the bioreactor, wherein said interior space is configured to receive and hold a culture medium with microbial or cellular liquid cultures; and at least one coupling element provided on the casing for coupling with a foam mitigation device for mitigation of foam built-up in the interior space of the bioreactor during use of the bioreactor for culturing of microorganisms or cells; wherein the coupling element is configured to allow ultrasonic waves generated by the foam mitigation device act upon foam built-up in the interior space of the bioreactor.
A bioreactor for culturing of microorganisms or cells comprising: a casing defining an interior space of the bioreactor, wherein said interior space is configured to receive and hold a culture medium with microbial or cellular liquid cultures; and at least one coupling element provided on the casing for coupling with a foam mitigation device for mitigation of foam built-up in the interior space of the bioreactor during use of the bioreactor for culturing of microorganisms or cells; wherein the coupling element is configured to allow ultrasonic waves generated by the foam mitigation device act upon foam built-up in the interior space of the bioreactor.
A system for freezing, storing, transporting, and thawing biopharmaceutical product, the system including a stationary equipment and one or more movable pallet, each pallet being configured to carry one or more container units, each containing biopharmaceutical product, the stationary equipment including a gas circulating unit configured to cause a circulation of cold gas and/or warm gas, from a pull inlet toward a blow outlet, wherein there is provided at least a first side plenum having one or more gas conveying channel therein, configured to be fluidly coupled to the blow outlet of the gas circulating unit, the first side plenum having a plurality of outlet ports directed toward an interior volume of the pallet, wherein the gas circulates substantially in a horizontal direction in the interior volume of the pallet.
F25D 11/00 - Self-contained movable devices associated with refrigerating machinery, e.g. domestic refrigerators
F25D 17/06 - Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating gas, e.g. by natural convection by forced circulation
F25D 25/02 - Charging, supporting, or discharging the articles to be cooled by shelves
75.
RAPID FREEZING, STORAGE, TRANSPORT, AND THAWING SYSTEM FOR CONTAINERS OF BIOPHARMACEUTICAL PRODUCTS
A system for freezing, storing, transporting, and thawing biopharmaceutical product includes a stationary equipment and one or more movable pallet (2), each pallet being configured to carry one or more container units containing biopharmaceutical product, the stationary equipment including a gas circulating unit configured to cause a circulation of cold gas and/or warm gas, from a pull inlet toward a blow outlet, wherein there is provided at least a first side plenum (31) having one or more gas conveying channel therein, configured to be fluidly coupled to the blow outlet of the gas circulating unit, the first side plenum having a plurality of outlet ports (33) directed toward an interior volume of the pallet, wherein the gas circulates substantially in a horizontal direction in the interior volume of the pallet. The container units may be bag assemblies, each comprising a single-use flexible bag (5) and a protective packaging.
Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.
B29C 37/00 - Component parts, details, accessories or auxiliary operations, not covered by group or
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
B29C 33/50 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles with means for collapsing or disassembling elastic
B29C 65/70 - Joining of preformed parts; Apparatus therefor by moulding
B29C 39/10 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. casting around inserts or for coating articles
B29C 39/34 - Moulds or cores for undercut articles
B29C 33/00 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor
B29K 19/00 - Use of rubber not provided for in a single one of main groups , as moulding material
B29C 33/12 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with incorporated means for positioning inserts, e.g. labels
B29C 33/44 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles
B29K 83/00 - Use of polymers having silicon, with or without sulfur, nitrogen, oxygen or carbon only, in the main chain, as moulding material
A fluid transfer assembly is described that includes a fitting comprising a lumen having an opening, and at least one barb, the at least one barb extending circumferentially around the lumen proximate to the opening. The assembly also includes a flexible conduit, a deformable sleeve, and an elastomeric liner disposed between the sleeve and the conduit. The fitting extends at least partially into the conduit such that the conduit extends over the at least one barb. The elastomeric liner applies substantially 360 degree radial pressure to the conduit such that the conduit is sealingly compressed around the at least one barb of the fitting. The assembly is fluid tight up to a burst pressure of the conduit.
F16L 33/22 - Arrangements for connecting hoses to rigid members; Rigid hose-connectors, i.e. single members engaging both hoses with means not mentioned in the preceding groups for gripping the hose between inner and outer parts
F16L 13/00 - Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints
F16L 13/14 - Non-disconnectable pipe joints, e.g. soldered, adhesive, or caulked joints made by plastically deforming the material of the pipe, e.g. by flanging, rolling
F16L 19/00 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts
F16L 19/04 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts using additional rigid rings, sealing directly on at least one pipe end, which is flared either before or during the making of the connection
F16L 33/00 - Arrangements for connecting hoses to rigid members; Rigid hose-connectors, i.e. single members engaging both hoses
F16L 33/20 - Undivided rings, sleeves, or like members contracted on the hose or expanded inside the hose by means of tools; Arrangements using such members
Cell separation systems, and methods for separating cells from microcarriers, and harvesting the separated cells, are provided, wherein the system comprises a cell separation device, a cell settling device, and a cell screening device.
A fluid transfer assembly is described. The fluid transfer assembly includes a unitary junction having an upstream portion and a downstream portion, the unitary junction defining a plurality of curved fluid pathways between the upstream portion and the downstream portion. The assembly also includes at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways.
B65B 3/00 - Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans or jars
B65B 3/04 - Methods of, or means for, filling the material into the containers or receptacles
C12M 1/00 - Apparatus for enzymology or microbiology
G01N 37/00 - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES - Details not covered by any other group of this subclass
80.
Fluid transfer assembly with a junction having multiple fluid pathways
A fluid transfer assembly is described. The fluid transfer assembly includes a unitary junction having an upstream portion and a downstream portion, the unitary junction defining a plurality of curved fluid pathways between the upstream portion and the downstream portion. The assembly also includes at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways.
B33Y 30/00 - ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING - Details thereof or accessories therefor
81.
Protecting system for containing a biopharmaceutical fluid
A protecting system for containing a biopharmaceutical fluid includes: a flexible pouch designed to contain a biopharmaceutical fluid; a protecting package including: two frames which respectively form a lower frame and an upper frame and which have a peripheral area; a fastening system able to clamp the two frames of the protecting package to each other, the frames sandwiching the flexible pouch. The fastening system includes at least an assembly only including: a snap including a backing part; and a cap including a washer. The lower and the upper frames of the protecting package are directly clamped between the washer of the cap and the backing part of the snap in a clamping position.
B65D 81/02 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
F16B 43/00 - Washers or equivalent devices; Other devices for supporting bolt-heads or nuts
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes - Details; Accessories therefor
F16B 21/08 - Releasable fastening devices with snap action in which the stud, pin, or spigot has a resilient part
F16B 19/00 - Bolts without screw-thread; Pins, including deformable elements; Rivets
82.
PROTECTING SYSTEM FOR CONTAINING A BIOPHARMACEUTICAL FLUID
Protecting system (10) for containing a biopharmaceutical fluid comprising: a flexible pouch (14) designed to contain a biopharmaceutical fluid a protecting package (112) comprising two frames (112A, 112B) which respectively form a lower frame and an upper frame and which have a peripheral area a fastening system (200) able to clamp the two frames (112A, 112B) of the protecting package (112) to each other, the frames (112A, 112B) sandwiching the flexible pouch (14) said fastening system (200) comprising at least an assembly (202) only comprising: a snap (210) comprising a backing part (212), and a cap (220) comprising a washer (222). The lower and the upper frames (112A, 112B) of the protecting package (112) are directly clamped between the washer (222) of the cap (220) and the backing part (212) of the snap (210) in a clamping position.
Disclosed is a method and system for freezing a biopharmaceutical fluid which is hold in a disposable container. The method includes the steps of arranging the container on the heat transfer surface area, cooling the heat transfer surface area to cool the bottom surface of the container until freezing and forming a layer of ice or an ice block of biopharmaceutical fluid inside the container; dislodging the ice layer or ice block frozen to the container. The steps of cooling the heat transfer surface area and dislodging the ice layer or ice block are repeated until the container is filled with a matrix of frozen biopharmaceutical fluid and liquid biopharmaceutical fluid, the liquid biopharmaceutical fluid occupying interstitial passages between ice layers or ice blocks of biopharmaceutical fluid. The cooling is then maintained until the freezing of the entire biopharmaceutical fluid held in the container.
A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.
Fluid transfer assemblies (100, 200) for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing (130, 230) and valves (140, 240) may be engaged with the conduits (110, 210) and/or body to control the fluid flow within the fluid transfer assembly.
B29C 33/48 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles with means for collapsing or disassembling
B67D 7/00 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
B67D 99/00 - Subject matter not provided for in other groups of this subclass
B29C 33/00 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor
B29C 33/50 - SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING - Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles with means for collapsing or disassembling elastic
86.
A FLUID TRANSFER ASSEMBLY, A FLUID TRANSFER SYSTEM, AND A RELATED METHOD
Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.
A fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough is provided. The fluid transport apparatus may include a conduit extending between a first terminus and a second terminus. The conduit may include platinum catalyzed silicone rubber having methyl and phenyl side groups. The conduit may have a storage modulus of 108 or less Pascals at -75 degrees Celsius. At least one fitting may be connected to the first terminus. A fluid storage accessory may be engaged with the second terminus. A related flexible conduit, method of manufacturing a flexible conduit, and storage method are also provided.
8 or less Pascals at −75 degrees Celsius. At least one fitting may be connected to the first terminus. A fluid storage accessory may be engaged with the second terminus. A related flexible conduit, method of manufacturing a flexible conduit, and storage method are also provided.
09 - Scientific and electric apparatus and instruments
Goods & Services
Scientific apparatus and instruments for the separation and
treatment of biological materials, namely, cells, organisms,
and cellular components and media.
90.
Detachable fluid transfer device accessory and a fluid transfer assembly
Detachable fluid transfer device accessories and fluid transfer assemblies are provided. The device accessories can include an upper extension defining a lower engagement surface; a lower extension defining an upwardly extending protrusion; a connector portion extending between the upper extension and the lower extension; and a resilient engagement member coupled to the lower engagement surface of the body. The upper extension, the lower extension, and the connector portion can collectively define a cavity configured to receive a tab assembly of a fluid transfer device, where the upwardly extending protrusion is configured to engage a housing of the fluid transfer device, and the resilient engagement member is configured to engage an upper surface of the tab assembly to retain the tab assembly in a fixed configuration relative to the housing.
B65B 1/04 - Methods of, or means for, filling the material into the containers or receptacles
B67D 7/02 - Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
B67D 7/78 - Arrangements of storage tanks, reservoirs or pipe-lines
91.
PROTECTING BODY FOR A FLEXIBLE POUCH, SYSTEM FOR CONTAINING A BIOPHARMACEUTICAL FLUID AND METHOD FOR USING SUCH A SYSTEM
The protecting package for a flexible pouch specially designed to contain a biopharmaceutical fluid, comprises two frames which respectively form a lower frame and an upper frame and which have a peripheral area, respectively to a main plane of the frames, each frame has an opening on a central area, the two frames are fixed to each other such that they are able to respectively surround two plates which sandwich the flexible pouch.
The protecting body (12) for a flexible pouch ( 14) is specially designed to contain a biopharmaceutical fluid. It comprises two substantially planar plates (12A,12B) which respectively form a lower surface and an upper surface and which are fixed to each other. The two plates are able to sandwich the flexible pouch for constraining the flexible pouch such that the protecting body is substantially planar, and comprises, on a peripheral side, at least one opening (24) able to receive at least one port of the flexible pouch.
The leak test for a flexible pouch specifically designed to contain a biopharmaceutical fluid comprises the following steps: the flexible pouch is sandwiched between two plates which have an internal surface able to allow gas which escape from a hole on the flexible pouch flowing out of an external surface of the flexible pouch, a gas is introduced within the flexible pouch, and the pressure within the flexible pouch is measured.
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
94.
Protecting body for a flexible pouch, system for containing a biopharmaceutical fluid and methods for using such a system
The protecting package for a flexible pouch specially designed to contain a biopharmaceutical fluid, includes two frames which respectively form a lower frame and an upper frame and which have a peripheral area, respectively to a main plane of the frames, each frame has an opening on a central area, the two frames are fixed to each other such that they are able to respectively surround two plates which sandwich the flexible pouch.
B65D 81/05 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
B65D 21/02 - Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
B65D 61/00 - External frames or supports adapted to be assembled around, or applied to, articles
B65D 77/06 - Liquids or semiliquids enclosed in flexible containers disposed within rigid containers
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes - Details; Accessories therefor
A61J 1/18 - Arrangements for indicating condition of container contents, e.g. sterile condition
95.
Protecting body for a flexible pouch, system for containing a biopharmaceutical fluid and methods for using such a system
The protecting body for a flexible pouch is specially designed to contain a biopharmaceutical fluid. It includes two substantially planar plates which respectively form a lower surface and an upper surface and which are fixed to each other. The two plates are able to sandwich the flexible pouch for constraining the flexible pouch such that the protecting body is substantially planar, and includes, on a peripheral side, at least one opening able to receive at least one port of the flexible pouch.
G01M 3/18 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for valves
G01M 3/32 - Investigating fluid tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for containers, e.g. radiators
An apparatus for manipulating particles includes: a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube connecting to a drum at the rear side of the rotor; a flexible conduit residing in the guide tube; and first and second elongate passageways for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.
A System for receiving a single-use vessel containing a mixing device comprises a support structure adapted to receive the single-use vessel and a drive-unit adapted to power, to control, or to power and control a mixing of contents of the single-use vessel when the single-use vessel is arranged in the support structure. Therein, the support structure and the drive-unit are provided as separate components that may be arranged both in an operating position, wherein the drive-unit is connectable to the mixing device of the single-use bag in the support structure, and in a separated position, wherein the drive-unit is separated from the support structure. The drive-unit comprises a tag reader that, in the operating position, is arranged to read a vessel tag of the single-use vessel arranged in the support structure.
