Abstract

A preparation method for a temperature-sensitive submucosal injection for endoscopic submucosal dissection, relating to the technical field of regenerative medicines. According to the specific method, a novel temperature-sensitive submucosal injection containing slow-release hemostatic drugs and growth factors is constructed by high-pH-value chitosan, polyvinylpyrrolidone, calcium ions and β-sodium glycerophosphate, the injection has low viscosity, and can be injected by means of a conventional endoscope injection needle clinically used at present, without the need to use a special injection device, and the injection rate is high. Moreover, after the injection is injected under a mucosal layer, high-strength hydrogel can be rapidly formed under the action of body temperature, an elevated state of the mucosal layer is supported more stably, ESD operation is facilitated, intraoperative and postoperative bleeding can be reduced, postoperative wound healing is promoted, and the injection has important clinical practical application significance.

IPC Classes  ?

• A61L 31/04 - Macromolecular materials
• A61L 31/00 - Materials for other surgical articles
• A61L 31/02 - Inorganic materials
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• A61L 31/14 - Materials characterised by their function or physical properties

Abstract

Disclosed in the present application are the use of an Aldo-Keto reductase family 1 member C3 (AKR1C3) inhibitor in the inhibition of lipid droplet generation and the promotion of lipid droplet degradation and in the preparation of a drug for treating or preventing MAFLD, a pharmaceutical composition containing the inhibitor, the use of the inhibitor as a drug for treating diseases associated with an abnormal increase in lipid droplets, a method for inhibiting Aldo-Keto reductase family 1 member C3 (AKR1C3), a method for constructing a gene engineering animal model with MAFLD, etc.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 3/06 - Antihyperlipidemics
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A01K 67/02 - Breeding vertebrates

Abstract

An anastomosis device, comprising a first stent (210) and a second stent (220), wherein the first stent (210) is provided with a first channel (211); the second stent (220) is provided with a second channel (221); the second stent (220) is connected to the first stent (210); the second stent (220) is located outside the first channel (211), and the first channel (211) is in communication with the second channel (221); or at least part of the second stent (220) is accommodated in the first channel (211). The anastomosis device has a small structural size, facilitating the placement of the anastomosis device into an implantation device, and thereby reducing the difficulty of using same.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts

Abstract

A tissue traction device (10) and a method for using the tissue traction device (10). The tissue traction device (10) an outer tube assembly (100), a clamping base (300), a clamping body (400) and an inhaul cable assembly (200). The clamping base (300) is connected to the distal end of the outer tube assembly (100), and the clamping body (400) is configured to clamp tissue and movably matches the clamping base (300). A first connecting structure is provided on the clamping body (400), a second connecting structure is provided on the clamping base (300), and the first connecting structure is connected to the second connecting structure, such that the clamping body (400) is in a clamping and locking state. The inhaul cable assembly (200) penetrates through the outer tube assembly (100), and the distal end of the inhaul cable assembly (200) is connected to the clamping body (400), such that the clamping body (400) is operated by means of the inhaul cable assembly (200). When the clamping body (400) is in a clamping and locking state, the outer tube assembly (100) is connected to the clamping base (300), and in this way, the clamping body (400) in the body can be pushed and pulled by operating the proximal end of the outer tube assembly (100) extending out of the body during use, tissue traction is further realized, and the surgical field can be better improved.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
• A61B 17/122 - Clamps or clips, e.g. for the umbilical cord

Abstract

A thermopuncture stent implantation device has a proximal end and a distal end, the distal end of a front handle is provided with an outer tube, an insulating middle tube is provided in the outer tube, a conductive part is provided in the insulating middle tube, a terminal of the proximal end of the conductive part is connected to an external power source, a boosting tube is provided between the proximal end of the outer tube and the insulating middle tube, the distal end of the boosting tube and the proximal end of the insulating middle tube are connected with each other, the distal end of the conductive part is provided with an insulating part, on which a conductive head connected with the conductive part is distributed; the stent, after being compressed, is located in a space between the distal end of the conductive part and the outer tube.

IPC Classes  ?

• A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
• A61B 18/14 - Probes or electrodes therefor
• A61L 29/02 - Inorganic materials
• A61L 29/14 - Materials characterised by their function or physical properties

Abstract

A retrievable puncture anchor includes a fixator with a cylindrical structure, a retrievable thread secured to one end of the fixator, and a push cable flexibly connected to a middle part of the fixator. Via the retrievable puncture anchor, tissues may be connected, fixed and matched with each other, or the tissues may be auxiliarily fixed, so that endoscopic surgery may be facilitated with simplified surgical process, and the puncture anchor may be retrieved after the surgery.

IPC Classes  ?

• A61B 17/34 - TrocarsPuncturing needles
• A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
• A61B 90/17 - Fixators for body parts, e.g. skull clampsConstructional details of fixators, e.g. pins for soft tissue, e.g. breast-holding devices
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

A hot-puncture stent implantation device. The stent implantation device comprise a proximal end and a distal end; the distal end of a front handle (30) is provided with an outer tube (21) which extends from the proximal end to the distal end; the outer diameter of the distal end of the outer tube (21) is smaller than or equal to 3.15 mm; an insulated intermediate tube (23) is provided in the outer tube (21); a conductive portion (13) is provided in the insulated intermediate tube (23); the insulated intermediate tube (23) and the conductive portion (13) extend from the proximal end to the distal end; the proximal end of the conductive portion (13) may be connected to an external power source; a boosting tube (22) is provided between the proximal end of the outer tube (21) and the insulated intermediate tube (23); the distal end of the boosting tube (22) is connected to the proximal end of the insulated intermediate tube (23); an insulated portion (12) is provided at the distal end of the conductive portion (13); conductive contacts (11) are distributed on the insulated portion (12); the conductive contacts (11) are connected to the conductive portion (13) to achieve a conductive function; in addition, the conductive portion (13) supports the stent; the compressed stent is located in the space between the distal end of the conductive portion (13) and the outer tube (21); the front handle (30) is connected to the proximal end of the outer tube (21) and may be moved backwards along the boosting tube (22) so as to drive the outer tube (21) to move backwards to release the stent.

IPC Classes  ?

• A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts

Abstract

A recoverable percutaneous anchor comprises a fixing device (1), a pull thread (2) and a push thread (3). The fixing device (1) is a cylindrical structure. The pull thread (2) is fixed at one end of the fixing device (1). The push thread (3) is flexibly connected to a middle section of the fixing device (1). The invention can connect, fix and staple tissues or perform assisted fixation of tissues, thereby facilitating smooth proceeding of an endoscopic surgery, simplifying a surgical procedure, and enabling recovery of a percutaneous anchor after completion of the surgery.

IPC Classes  ?

• A61B 17/02 - Surgical instruments, devices or methods for holding wounds open, e.g. retractorsTractors
• A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
• A61B 90/17 - Fixators for body parts, e.g. skull clampsConstructional details of fixators, e.g. pins for soft tissue, e.g. breast-holding devices

Abstract

The invention discloses a one-piece stent implanter, including a front handle and a rear handle; the front end of the front handle is provided with an outer pipe whose top is flexibly connected with a cautery tip, the outer pipe is internally provided with a middle pipe and a stent; the rear handle includes a stainless steel pipe for supporting and an inner pipe positioned in the stainless steel pipe, the top of the inner pipe is fixedly connected to the cautery tip; one end of the middle pipe is mutually touched and connected with one end of the stent, while the other end of the middle pipe is mutually connected with the stainless steel pipe; one end of the stent is close to the cautery tip, with a certain gap kept; when the front handle is retreated along the stainless steel pipe, the outer pipe simultaneously retreats and separates from the cautery tip, positions of the middle pipe and the rear handle remain unchanged, and the stent is automatically released. The invention wherein the stent can be directly implanted into a nidus organ incised and an access from the outside to the nidus organ is established, so that other medical apparatuses and instruments can be continuingly used for removal (including other surgeries) of infectious agents or necrotic tissues, thus increasing comprehensiveness of surgeries and avoiding patients from suffering from repeated operations.

IPC Classes  ?

• A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
• A61B 18/14 - Probes or electrodes therefor
• A61B 17/34 - TrocarsPuncturing needles
• A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts