A traditional Chinese medicine composition having efficacy in treating colds and a use thereof. The traditional Chinese medicine composition is prepared from perilla leaf, cabline potchouli, all-grass of haichow elsholtzia, bark of officinal magnolia, root of baikal skullcap, alum-processed pinellia ternata tuber, lonicera confusa, weeping forsythia capsule, Fu Ling, dried tangerine peel, and fresh ginger, and is capable of relieving exterior syndrome and harmonizing the middle, expelling uncleanliness and resolving dampness, and treating symptoms such as cold, fever, aversion to wind, stuffy and runny nose, headache and drowsiness, nausea and vomiting, diarrhea, heaviness in limbs, abdominal swelling and pain, decreased appetite and anorexia.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chinese traditional medicinal herbs; Chinese patent
medicines; medicinal herb extracts; probiotic preparations
for medical purpose; medicated animal feed; feed supplements
for medical purposes; pre-filled douche bags containing
medicated cleaning preparations.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Tonics [medicines]; dietary fibre; disinfectants; chinese
patent medicines; medicinal tea; medicinal herbs; medicines
for human purposes; chinese traditional medicinal herbs;
nutritional supplements; dietetic substances adapted for
medical use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Tonics [medicines]; dietary fibre; disinfectants; Chinese
patent medicines; medicinal tea; medicinal herbs; medicines
for human purposes; Chinese traditional medicinal herbs;
nutritional supplements; dietetic substances adapted for
medical use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chinese traditional medicinal herbs; Chinese patent
medicines; dietary fiber to aid digestion; dietary fibre;
pharmaceutical preparations for the treatment of immune
system related diseases and disorders; ganoderma lucidum
spore powder for medical purpose; plant extracts for
pharmaceutical purposes; herb extracts for medical purpose;
tonics [medicines]; medicines for human purposes; medicinal
herbs; dietary food supplements for stimulating the growth
of probiotic; dietetic preparations adapted for medical
purposes; nutritional supplements; dietetic substances
adapted for medical use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Tonics [medicines]; dietary fibre; disinfectants; Chinese patent medicines; medicinal tea; medicinal herbs; medicines for human purposes; Chinese traditional medicinal herbs; nutritional supplements; dietetic substances adapted for medical use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Tonics [medicines]; dietary fibre; disinfectants; chinese patent medicines; medicinal tea; medicinal herbs; medicines for human purposes; chinese traditional medicinal herbs; nutritional supplements; dietetic substances adapted for medical use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chinese traditional medicinal herbs; Chinese patent medicines; medicinal herb extracts; probiotic preparations for medical purpose; medicated animal feed; feed supplements for medical purposes; pre-filled douche bags containing medicated cleaning preparations.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chinese traditional medicinal herbs; Chinese patent medicines; dietary fiber to aid digestion; dietary fibre; pharmaceutical preparations for the treatment of immune system related diseases and disorders; ganoderma lucidum spore powder for medical purpose; plant extracts for pharmaceutical purposes; herb extracts for medical purpose; tonics [medicines]; medicines for human purposes; medicinal herbs; dietary food supplements for stimulating the growth of probiotic; dietetic preparations adapted for medical purposes; nutritional supplements; dietetic substances adapted for medical use.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chinese traditional medicinal herbs; Chinese patent medicines for use in improvement of kidney function; dietary fiber to aid digestion; dietary fibre to treat kidney disease; pharmaceutical preparations for the treatment of immune system related diseases and disorders; ganoderma lucidum spore powder for medical purpose; plant extracts for pharmaceutical purposes, other than essential oils; herbal extracts for medical purpose, other than essential oils; tonics being medicines for improvement of kidney function; medicines for anti-aging for human purposes; medicinal herbs; dietary food supplements for stimulating the growth of probiotic flora; dietetic preparations adapted for medical purposes; nutritional supplements; dietetic foods adapted for medical use
The present invention provides a compound or a pharmaceutically acceptable salt, isomer, prodrug, polymorph or solvate thereof, and a preparation method therefor and use thereof. The compound provided in the present invention has comparable or superior activity to Elagolix as a GnRHR antagonist in calcium flux assays and have better pharmacokinetic properties.
A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61P 5/02 - Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
A61P 5/24 - Drugs for disorders of the endocrine system of the sex hormones
A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
13.
METHOD FOR DETERMINING FINGERPRINT OF TRADITIONAL CHINESE MEDICINE COMPOSITION
Disclosed is a method for determining a fingerprint of a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following bulk drugs: Ephedrae herba, Gypsum fibrosum, Forsythiae fructus, Scutellariae radix, Mori cortex, Armeniacae semen amarum, Peucedani radix, Pinelliae rhizoma, Citri reticulatae pericarpium, Fritillaria, Arctii fructus, Lonicerae japonicae flos, Rhei radix et rhizoma, Platycodonis radix, and Glycyrrhizae radix et rhizoma. According to the method for determining the fingerprint, 22 main chromatographic peaks are calibrated, and 14 of same were identified, namely neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoforsythiaside A, forsythiaside A, hesperidin, baicalin, arctiin, aloe emodin, ammonium glycyrrhizinate, chrysophanol, emodin, rhein and physcion.
Provided is a panel of monoclonal antibodies which specifically bind to CLDN18.2 and do not specifically bind to CLDN18.1, and optionally have an engineered Fc region.
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
15.
MONOCLONAL ANTIBODIES AGAINST CLDN18.2 AND FC-ENGINEERED VERSIONS THEREOF
A panel of monoclonal antibodies which specifically bind to CLDN18.2 and do not specifically bind to CLDN18.1, and optionally have an engineered Fc region is provided.
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
Provided is a panel of monoclonal antibodies which specifically bind to CLDN18.2 and do not specifically bind to CLDN18.1, and optionally have an engineered Fc region.
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C12N 15/62 - DNA sequences coding for fusion proteins
C12N 15/64 - General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A panel of monoclonal antibodies which specifically bind to CLDN18.2 and do not specifically bind to CLDN18.1, and optionally have an engineered Fc region is provided.
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A panel of monoclonal antibodies which specifically bind to CLDN18.2 and do not specifically bind to CLDN18.1, and optionally have an engineered Fc region is provided.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
19.
MONOCLONAL ANTIBODIES AGAINST CLDN18.2 AND FC-ENGINEERED VERSIONS THEREOF
A panel of monoclonal antibodies which specifically bind to CLDN18.2 and do not specifically bind to CLDN18.1, and optionally have an engineered Fc region is provided.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The use of a traditional Chinese medicine composition in the preparation of a drug for resisting novel coronavirus with a D614G mutation in the S protein. The traditional Chinese medicine composition is prepared from Forsythiae fructus, Lonicerae japonicae flos, Isatidis radix, Rhei radix et rhizoma, Pogostemonis herba, Dryopteridis crassirhizomatis rhizoma, Rhodiolae crenulatae radix et rhizoma, L-menthol, Ephedrae herba, Armeniacae semen amarum, Houttuyniae herba, Glycyrrhizae radix et rhizoma and Gypsum fibrosum; and has the effects of removing pathogens, relieving symptoms and regulating immunity.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Nutritional supplements; pharmaceutical preparations;
dietetic foods adapted for medical purposes; nutraceutical
preparations for therapeutic or medical purposes; Chinese
patent medicines; medicinal herbs; dietary fiber; tonics
[medicines]; cardiotonic; medical cardiovascular drug.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Nutritional supplements; pharmaceutical preparations;
dietetic foods adapted for medical purposes; nutraceutical
preparations for therapeutic or medical purposes; chinese
patent medicines; medicinal herbs; dietary fiber; tonics
[medicines]; cardiotonic; medical cardiovascular drug.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Hand soap; nasal cleansing preparations for personal
hygiene; fruit and vegetable detergent; paper towel
impregnated with cleaning preparations; wet tissue
impregnated with a detergent for cleaning; aromatic
essential oil; essential oils; phytocosmetic preparations;
cosmetics; hand cream; dentifrices; breath freshening
sprays; fragrances for cars; air fragrancing preparations. Traditional Chinese medicinal preparations; medicinal herb
extracts; plant extracts for pharmaceutical purposes;
pharmaceutical preparations for the treatment of respiratory
diseases; antiseptics; antibacterial handwashes;
antibacterial hand sanitizer; sterilising preparations;
antiviral drugs; antiviral preparations; pharmaceutical
products for the treatment of respiratory diseases; medicine
for treating viral disease; disinfectants for hygiene
purposes; hand sanitizer gel; disinfectants; mineral food
supplements; nutritional supplements; dietary supplement to
stimulate the growth of probiotics; nutritional additives to
foodstuffs for animals for medical use; disinfectant wipes.
24.
APPLICATION OF TRADITIONAL CHINESE MEDICINE COMPOSITION IN PREPARATION OF ANTI-SARS VIRUS DRUGS
An application of a traditional Chinese medicine composition in the preparation of anti-SARS virus drugs. The traditional Chinese medicine composition is prepared from herba ephedrae, gypsum fibrosum, fructus forsythia, radix scutellariae, cortex mori, semen armeniacae amarae, radix peucedani, rhizoma pinelliae, pericarpium citri reticulatae, bulbus fritillariae cirrhosae, fructus arctii, flos lonicerae, radix et rhizoma rhei, radix platycodi, and radix glycyrrhizae. The traditional Chinese medicine composition exerts the overall regulation advantage of a compound traditional Chinese medicine, and has multi-directional, multi-level and multi-target characteristics. It has been proved by in vivo and in vitro experiments that the traditional Chinese medicine composition can effectively kill SARS viruses, and the effect is remarkable.
A traditional Chinese medicine composition and an application thereof. The traditional Chinese medicine composition is prepared from active pharmaceutical ingredients ephedra, gypsum, weeping forsythia capsule, root of baikal skullcap, white mulberry root-bark, bitter apricot seed, root of grand hogfennel, tuber of pinellia, dried tangerine peel, bulb of fritillary, achene of great burdock, honeysuckle flower, root and rhizome of sorrel rhubarb, platycodon root, and root of ural licorice, and has the effects of resisting virus, protecting organ, and improving immunity.
30 - Basic staples, tea, coffee, baked goods and confectionery
Goods & Services
Tea; tea-based beverages with flowers and plants; flowers or
leaves for use as tea substitutes; teabag; herbal tea-based
beverages; cookies; pastries; snow pear paste; fine dried
noodles; rice flour paste; Konjac powder.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Hand soap; nasal cleansing preparations for personal sanitary purposes; fruit and vegetable wash; paper towel impregnated with detergent for cleaning purposes; wet tissue impregnated with a detergent for cleaning; aromatic essential oil; essential oils for cosmetic purposes; essential oils for personal use; phytocosmetic preparations in the form of creams, gels, foams, lotions, milks, oils, pastes; cosmetics; hand cream; dentifrices; breath freshening sprays; fragrances for cars; air fragrancing preparations
(2) Traditional Chinese medicinal preparations for controlling blood pressure; Traditional Chinese medicinal preparations for the treatment of colds and flu; medicinal herb extracts, namely ginger extract, ginseng extract; extracts of hops for pharmaceutical purposes; plant extracts for pharmaceutical purposes, namely for pain relief; plant extracts for pharmaceutical purposes for the treatment of colds and flu; plant extracts for pharmaceutical purposes for controlling blood pressure pharmaceutical preparations for the treatment of respiratory diseases; antiseptics; antibacterial handwashes; hand sanitizer; sterilising preparations namely, disinfectants for sterilization; antivirals; antiviral pharmaceutical preparations; pharmaceutical products for the treatment of respiratory diseases; medicine for treating viral disease, namely viral skin infections and sexually transmitted diseases; disinfectants for hygiene purposes, namely handwash; hand sanitizer gel; all-purpose disinfectants; mineral food supplements; nutritional supplements consisting of vitamins and minerals; nutritional supplements for general health and well being; probiotic dietary supplements; nutritional supplements for animal foodstuffs, for medical purposes; disposable disinfecting wipes
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Traditional Chinese medicinal preparations, namely, antimicrobial preparations for medicinal use for inhibiting growth of bacteria, fungi, and viruses; medicinal herb extracts; plant extracts for pharmaceutical purposes; pharmaceutical preparations for the treatment of respiratory diseases; antiseptics; antibacterial handwashes; antibacterial hand sanitizer; sterilising preparations; antiviral drugs; antiviral preparations; pharmaceutical products for the treatment of respiratory diseases; medicines for treating viral disease; disinfectants for hygiene purposes; hand sanitizer gel; disinfectants; mineral food supplements; nutritional supplements; dietary supplements to stimulate the growth of probiotics; nutritional additives to foodstuffs for animals for medical use for use as nutritional supplements; disinfectant wipes Traditional Chinese medicinal preparations including antimicrobial preparations for medicinal use; medicinal herb extracts; plant extracts for pharmaceutical purposes; pharmaceutical preparations for the treatment of respiratory diseases; antiseptics; antibacterial handwashes; antibacterial hand sanitizer; sterilising preparations; antiviral drugs; antiviral preparations; pharmaceutical products for the treatment of respiratory diseases; medicines for treating viral disease; disinfectants for hygiene purposes; hand sanitizer gel; disinfectants; mineral food supplements; nutritional supplements; dietary supplements to stimulate the growth of probiotics; nutritional additives to foodstuffs for animals for medical use for use as nutritional supplements; disinfectant wipes
29.
ANTIMICROBIAL ESSENTIAL OIL COMPOSITION, PRODUCT COMPRISING SAME, AND PREPARATION METHOD FOR PRODUCT THEREOF
Disclosed is an antimicrobial essential oil composition comprising: carvacrol; thymol; and one or more selected from lemon oil, sweet orange oil, daidai peel oil, sweet lemon oil and shaddock oil; one or more selected from the group consisting of Asian peppermint oil, cornmint oil, peppermint oil, and pennyroyal oil; one or more selected from the group consisting of laureth oil and glycine: one or more selected from the group consisting of patchouli oil, sandalwood oil and rosemary oil; one or more selected from the group consisting of geranium oil, pine needle oil, and cedarwood oil; and optionally one or more selected from the group consisting of perilla oil, chrysanthemum oil, and Chinese chaste tree oil. A product containing the antimicrobial essential oil composition, a product containing the antimicrobial essential oil composition, and a preparation method of the product thereof are also disclosed.
The present invention provides a method for separation and structural identification of relevant metabolites of Lianhua Qingwen drugs. The method comprises: separating, by using the following chromatographic conditions, relevant metabolites in body fluids of individuals administrated Lianhua Qingwen drugs: a chromatographic column: C18 chromatographic column; mobile phases: A: 0.1 % aqueous formic acid solution, and B: acetonitrile, the volume ratio of A to B being (98-5):(2-95); flow velocity: 0.3 mL/min; and column temperature: 35°C.
Provided in the present invention are a metabolite at position 21 of Fenlean, and the preparation and the use thereof. The metabolite at position 21 of Fenlean of the present invention has a good antioxidant activity and anti-neuroinflammatory and neuroprotective activities. The metabolite at position 21 of Fenlean is as represented by the following formula (I): (I)
Provided in the present invention are a Fenlean 7 position metabolite, and the preparation and the use thereof. The Fenlean 7 position metabolite of the present invention has a good antioxidant activity and anti-neuroinflammation and neuroprotection activity. At the same time, the Fenlean 7 position metabolite can more easily penetrate the blood-brain barrier than Fenlean, thereby having a better targeting effect. In addition, the exposure dose of the Fenlean 7 position metabolite of the present invention in the human body is higher than that of Fenlean. The Fenlean 7 position metabolite is as represented by the following formula (I):
An application of an SMS2 inhibitor in the preparation of a drug for the treatment of highly invasive breast cancer. According to overall experiments using 4T1 cells to establish a mouse triple-negative breast cancer model and in vitro experiments using primary bone marrow macrophages from mice, it is confirmed that compound I, as an SMS2 specific inhibitor, is able to effectively inhibit type 2 polarization of macrophages by decreasing sphingomyelin synthase 2 activity and sphingolipid levels in vivo, and is able to remold a tumor microenvironment by reducing M2-type macrophages in the tumor microenvironment of triple-negative breast cancer and by reducing the extent of infiltration of other myeloid-derived immunosuppressive cells, thereby inhibiting the in situ growth of the triple-negative breast cancer as well as the formation and growth of pulmonary metastases brought about through blood circulation. Inhibition of SMS2 activity may be used to prevent and treat highly invasive malignant breast cancers comprising triple-negative breast cancer.
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A compound having a chemical structure represented by Formula I is provided. Also provided are a pharmaceutically acceptable salt or isomer thereof, a preparation method therefor and use thereof. Further provided are compositions and pharmaceutical formulations comprising the compound, salt, or isomer. The disclosed chemical compounds, compositions, and formulations are useful for treating gonadal hormone-related diseases or for preparing drugs, compositions and pharmaceutical formulations to treat such diseases, such as gonadotropin-releasing hormone receptor antagonists. I
C07D 239/54 - Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 5/02 - Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
35.
USE OF PHARMACEUTICAL COMPOSITION IN PREPARING ANTI-VIRAL DRUG
A use of a pharmaceutical composition in preparing an anti-viral drug, the pharmaceutical composition being made from Ephedra sinica, gypsum, Forsythia, Scutellaria baicalensis, white mulberry root bark, bitter apricot kernel, radix peucedani, pinelliae rhizoma, chenpi, fritillary bulb, greater burdock fruit, Flos Lonicerae japonicae, Rheum officinale, Chinese bellflower, and Glycyrrhiza uralensis.
gypsum. In the method for determining the content, the content of the menthol in the composition is determined by gas chromatography to effectively control the content of menthol in the composition, and the method can save energy and reduce the costs for analysis.
Disclosed is the use of a pharmaceutical composition in the preparation of a drug for treating acute lung injury. The pharmaceutical composition is prepared from Ephedrae herba, Gypsum fibrosum, Forsythiae fructus, Scutellariae radix, Mori cortex, Armeniacae semen amarum, Peucedani radix, Pinelliae rhizoma, Citri reticulatae pericarpium, Fritillaria, Arctii fructus, Lonicerae japonicae flos, Rhei radix et rhizoma, Platycodonis radix, and Glycyrrhizae radix et rhizoma.
A use of a pharmaceutical composition in preparing an anti-viral drug, the pharmaceutical composition being made from Ephedra sinica, gypsum, Forsythia, Scutellaria baicalensis, white mulberry root bark, bitter apricot kernel, radix peucedani, pinelliae rhizoma, chenpi, fritillary bulb, greater burdock fruit, Flos Lonicerae japonicae, Rheum officinale, Chinese bellflower, and Glycyrrhiza uralensis.
A use of a pharmaceutical composition in preparing an antibacterial drug, the pharmaceutical composition being made from Ephedra sinica, gypsum, Forsythia, Scutellaria baicalensis, white mulberry root bark, fried bitter apricot kernel, radix peucedani, pinelliae rhizoma, chenpi, Bulbus Fritillariae thunbergii, greater burdock fruit, Flos Lonicerae japonicae, Rheum officinale, Chinese bellflower, and Glycyrrhiza uralensis, used to inhibit the Gram-positive bacteria Staphylococcus aureus, group A hemolytic streptococcus, group B hemolytic streptococcus, and Diplococcus pneumoniae, and the Gram-negative bacteria Escherichia coli and Shigella dysenteriae.
A use of a pharmaceutical composition in preparing an antibacterial drug, the pharmaceutical composition being made from Ephedra sinica, gypsum, Forsythia, Scutellaria baicalensis, white mulberry root bark, fried bitter apricot kernel, radix peucedani, pinelliae rhizoma, chenpi, Bulbus Fritillariae thunbergii, greater burdock fruit, Flos Lonicerae japonicae, Rheum officinale, Chinese bellflower, and Glycyrrhiza uralensis, used to inhibit the Gram-positive bacteria Staphylococcus aureus, group A hemolytic streptococcus, group B hemolytic streptococcus, and Diplococcus pneumoniae, and the Gram-negative bacteria Escherichia coli and Shigella dysenteriae.
Use of a pharmaceutical composition in the preparation of a medicament for preventing and treating novel coronavirus-infected pneumonia. The pharmaceutical composition is prepared from forsythia, honeysuckle, isatis root, Rheum officinale, Pogostemon cablin, Rhizoma Dryopteris Crassirhizomae, Rhodiola rosea, menthol, honey-fried Herba ephedra, fried Semen Armeniacae Amarae, Houttuynia cordate, liquorice and gypsum fibrosum. It is experimentally verified that the pharmaceutical composition has the effect of preventing and treating novel coronavirus-infected pneumonia.
Use of a pharmaceutical composition in the preparation of a medicament for preventing and treating novel coronavirus-infected pneumonia. The pharmaceutical composition is prepared from forsythia, honeysuckle, isatis root, Rheum officinale, Pogostemon cablin, Rhizoma Dryopteris Crassirhizomae, Rhodiola rosea, menthol, honey-fried Herba ephedra, fried Semen Armeniacae Amarae, Houttuynia cordate, liquorice and gypsum fibrosum. It is experimentally verified that the pharmaceutical composition has the effect of preventing and treating novel coronavirus-infected pneumonia.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Shower creams; body lotion; hair dyes; hair conditioners; all-purpose cleaning preparations; laundry preparations, namely laundry detergents, fabric softener, laundry bleach; dishwashing detergents; hand soap; fruit and vegetable wash; skin toners; beauty gels; anti-aging cosmetic gel; hand cream; lip balm; air fragrancing preparations; fragrance sachets; aromatherapy essential oil; gem water, namely, perfume, eau de parfum, eau de toilette, toilet water, cologne; cosmetics
(2) Germicides; antifungal medications; depuratives for the body; disinfectants for chemical toilets; fungicides for household purposes; biological fungicides; medicine for treating infectious disease, namely respiratory infections, eye infections; dietary fiber to aid digestion; antivirals; virucides; antibacterial sprays, soaps and gels; medical antifungal cream; antibacterial handwashes; medicated after-shave lotions; sanitary pads, tampons, panty liners; all-purpose disinfectants; intestinal disorder medicine for treatment of intestinal bacteria; air deodorising preparations; disposable disinfecting wipes; antiseptic cotton; adhesive bandages impregnated with antibacterial gel; nasal rinse, nasal spray preparations; sterile dressings
(3) Therapeutic facial masks; respiratory masks for medical purposes; medical respirator; hyperbaric oxygen chambers for medical purposes; incontinence sheets; masks for use by medical personnel; surgical drapes; sanitary masks for medical purposes; respirators for artificial respiration; medical isolation clothing, namely clothing especially for operating rooms and sterilized clothing for surgical purposes; protective clothing for medical use; dust-proof sanitary mask for medical use; oxygen mask for medical use
Disclosed is an ureido-containing benzimidazole derivative, wherein the general structural formula is as shown in formula (I). Also disclosed are a method for preparing the compound and the use thereof in the preparation of anti-chronic kidney disease drugs. The present invention is an inhibitor of selective homology domain interaction protein kinase-2(HIPK2), which can simultaneously down-regulate the protein level of HIPK2, play a dual role, has an inhibitory effect on HIPK2 kinase, protein levels, and the phosphorylation level of the fibrosis signal molecule smad3 and the inflammation signal molecule IκB-α, can simultaneously regulate fibrosis and inflammatory processes, and has a good market application prospect in terms of drugs for treating chronic kidney disease.
C07C 275/18 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
C07C 275/20 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
47.
METHOD FOR IDENTIFYING VARIOUS INGREDIENTS IN TRADITIONAL CHINESE MEDICINE COMPOSITION AND MEASURING CONTENTS
A method for identifying various ingredients in a Herba Ephedrae-containing traditional Chinese medicine composition and measuring contents. Thin layer chromatography is used to identify pharmaceutical ingredients such as Bulbus Fritillariae Thunbergii, Fructus Forsythiae, Great Burdock Achene, Radix et Rhizoma Rhei, and Radix Glycyrrhizae, and high performance liquid chromatography is used to measure the contents of Herba Ephedrae and Pericarpium Citri Reticulatae. The method has high sensitivity and strong specificity, and can be used to efficiently, rapidly, comprehensively, and accurately control the quality of the traditional Chinese medicine composition.
The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).
C07C 235/34 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
49.
Alkoxybenzo-five-membered (six-membered) heterocyclic amine compound and pharmaceutical use thereof
Alkoxybenzeno five- or six-member heterocyclic amines compounds, their pharmaceutically acceptable salts, and pharmaceutical compositions are used as the active ingredients, and their application in drugs which can prevent and cure diseases caused by abnormal increasing of SM. These diseases caused by abnormal increasing of SM include atherosclerosis, type II diabetes, fatty liver, obesity, metabolic syndromes, enteritis and other inflammatory diseases.
C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 261/20 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
50.
Method for separating eighteen components in traditional Chinese medicine composition
The disclosure provides a method for separating eighteen components in a traditional Chinese medicine composition, including: (1) preparing the traditional Chinese medicine composition into a total extract of the traditional Chinese medicine composition, separating by resin through sequentially eluting with water, 10% ethanol and 30% ethanol, and collecting the 30% ethanol eluate to obtain a 30% ethanol extract; (2) adding the 30% ethanol extract to a reverse phase silica gel ODS-AQ-HG, and separating in a medium pressure separation column to obtain differently numbered elution dry pastes; (3) dissolving the differently numbered elution dry paste with 30% methanol as a solvent, and passing the solution through a 0.45 μm microporous membrane, carrying out a primary separation by high performance liquid chromatography and collecting chromatographic peaks with different retention times, and further purifying by high performance liquid chromatography; finally obtaining the components of eighteen components.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
B01D 15/26 - Selective adsorption, e.g. chromatography characterised by the separation mechanism
A61K 36/63 - Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
51.
Method for separating eight components in Chinese traditional medicine composition
The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among components of a compound medicine, systematic researches on the material basis is very necessary. Accordingly, deep researches are done on chemical components of the pharmaceutical composition in the solution, and eight compounds are separated, which are 10-O-(p-hydroxycinnamoyl)-adoxosidic acid, aloe-emodin-8-O-β-D-glucopyranoside, quercitrin, matairesinol-4′-O-glucoside, liquiritin apioside, epi-vogeloside, vogeloside and ethyl caffeate, which provides a new quality control method for the composition in the solution.
A composition for assisting in improving memory is prepared from particular parts by weight of raw materials: Eleutherococcus senticosus, ginseng, fructus alpiniae oxyphyllae, and Schisandra chinensis. The combination of these medicines can reinforce deficiency, invigorate the kidney, secure essence and enrich marrow to cure roots, nourish qi to generate fluid, promote blood circulation to remove meridian obstruction, and address both symptoms and root causes. The composition can effectively improve and enhance learning and memory abilities.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/00 - Drugs for disorders of the nervous system
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary fiber; Chinese medicine nostrum; drug used to treat
respiratory diseases; nutritional supplements; medicines for
human purposes; pillows filled with Chinese medicines;
tonics [medicines]; pharmaceutical preparations;
antibacterial handwashes; disinfectants.
54.
TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF
A traditional Chinese medicine composition, prepared from the following traditional Chinese medicine crude drugs in part by weight: 200-300 parts of fructus forsythia, 60-100 parts of herba ephedrae, 40-60 parts of rheum, 200-300 parts of herba houttuyniae, 200-300 parts of flos lonicerae, 200-300 parts of radix isatidis, 60-100 parts of herba pogostemonis, 200-300 parts of rhizoma dryopteris crassirhizomae, 60-100 parts of rhodiola rosea L., 5-9 parts of menthol, 60-100 parts of semen armeniacae amarum, 60-100 parts of radix glycyrrhizae, and 200-300 parts of gypsum. The traditional Chinese medicine composition comprises the following components: 0.4-0.9 mg/g of ephedrine hydrochloride and pseudoephedrine hydrochloride, 2.2-4.3 mg/g of amygdalin, 0.25-0.75 mg/g of chrysophanol, 0.15-0.40 mg/g of rheum emodin, 2.4-5.4 mg/g of chlorogenic acid, 1.4-2.7 mg/g of neochlorogenic acid, 1.6-3.4 mg/g of cryptochlorogenic acid, 2.0-5.5 mg/g of isopsythioside A, 1.65-2.90 mg/g of 4,5-di-o-caffeoylquinic acid, 2.7-3.8 mg/g of quercitrin, 1.4-2.9 mg/g of glycyrrhizic acid, and 2.5-3.4 mg/g of phillyrin. The traditional Chinese medicine composition has the effect of treating cold and upper respiratory infection.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary fiber; chinese patent medicines; medicinal herbs;
nutritional supplements; medicines for human purposes;
tonics [medicines]; pharmaceutical preparations; medicinal
health care preparations; dietetic foods adapted for medical
purposes.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Nutritional supplements for general health and well-being; Pharmaceutical preparations for the treatment of infectious diseases, namely respiratory infections, respiratory system diseases, namely acute upper respiratory tract infection, acute tracheitis and bronchitis, chronic bronchitis, acute and chronic laryngopharyngitis, acute and chronic tonsillitis; Dietetic foods for treating and preventing conditions associated with high blood lipid levels and high blood sugar; dietetic foods used to combat the effects of fatigue and tiredness and to promote and stimulate physical and mental alertness; Dietetic foods used for the treatment of intoxication caused by toxins; Nutraceutical preparations for therapeutic and medical purposes, namely for the reduction of blood sugar levels, nutraceutical for the reduction of high cholesterol and nutraceutical for the treatment of cardiovascular conditions, nutraceutical for the treatment of insomnia and depression; Chinese patent medicines; Medicinal herbs in dried and preserved form used for promoting blood flow and general well-being; Dietary fiber to aid digestion; Herbal tonics for energy; Dietary supplements for general health and well-being; Dietary supplements for human consumption; Dietary supplements consisting of amino acids, minerals and trace elements
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary fiber; nutritional supplements; dietetic foods
adapted for medical purposes; medicines for treatment of
respiratory diseases; germicides; antiseptics;
disinfectants; medicines for human purposes; pharmaceutical
preparations; chinese patent medicines; pharmaceutical
preparations for the treatment of cardiovascular diseases;
antibacterial handwashes.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary fiber to aid digestion; medicinal herbs; nutritional supplements; medicines for treatment of respiratory diseases; tonics, namely, liquid nutritional supplements; pharmaceutical preparations for the treatment of cardiovascular diseases; dietetic foods adapted for medical purposes
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dietary fiber to aid digestion; nutritional supplements; dietetic foods adapted for medical purposes; medicines for treatment of respiratory diseases; germicides; antiseptics; disinfectants; Chinese traditional medicinal herbs; pharmaceutical preparations for the treatment of cardiovascular diseases; antibacterial handwashes
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Nutritional supplements for general health and well-being; Antibacterial soap
(2) Medicines for the treatment of respiratory diseases; Pharmaceutical preparations for the treatment of infectious diseases, namely respiratory infections, respiratory system diseases, namely acute upper respiratory tract infection, acute tracheitis and bronchitis, chronic bronchitis, acute and chronic laryngopharyngitis, acute and chronic tonsillitis; nutraceuticals as a sleep aid; dietary food supplements in the nature of mixed herbal infusions for reducing cholesterol; nutraceuticals for reducing stress and fatigue; nutritional supplement for eliminating toxins from the intestinal tract; dietary supplements consisting of amino acids, minerals and trace elements; dietary and nutritional supplements used for weight loss; dietary and nutritional supplements to promote healthy bones, joints and muscles; herbal and dietary supplements for promoting faster muscle recovery after exercise; preparations for the treatment of cardiovascular diseases; natural medicines for maintaining blood sugar levels; nutraceutical for the reduction of high cholesterol and nutraceutical for the treatment of cardiovascular conditions, nutraceutical for the treatment of insomnia and depression; Antibacterial hand washes; Chinese traditional medicinal herbs for the treatment of colds and flu; Antiseptics; Chinese traditional medicinal herbs for controlling blood pressure; Germicides; All-purpose disinfectants; Dietary fiber to aid digestion; dietary and nutritional supplements used for energy stimulation; Dietary supplements for general health and well-being; Vitamin and mineral dietary supplements for human consumption; Dietary supplements consisting of amino acids, minerals and trace elements
61.
Type-G crystal form of fenolamine, preparation method, composition and use thereof
The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).
C07C 233/22 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Nutritional supplements; Medicines for the treatment of respiratory diseases; Pharmaceutical preparations; Dietetic foods adapted for medical purposes; Pharmaceutical preparations for the treatment of cardiovascular diseases; Nutraceutical preparations for therapeutic or medical purposes; Antibacterial handwashes; Chinese patent medicines; Antiseptics; Medicinal herbs; Germicides; Antibacterial soap; Disinfectants; Dietary fiber; Tonics [medicines]; Dietary supplements; Dietary supplements for human consumption; Dietary supplements consisting of amino acids, minerals and trace elements.
(1) Electrocardiographs; atomizers sold empty for medical purposes; Soporific pillows for insomnia; Diagnostic apparatus for medical purposes, namely ultrasonic medical diagnostic apparatus, magnetic resonance imaging (MRI) diagnostic apparatus; Medical apparatus and instruments, namely medical instruments for general examination, medical instruments for cutting tissue, surgical instruments, magnetic resonance CT apparatus, medical x-ray apparatus, medical ultrasound apparatus, apparatus for blood analysis, namely, apparatus for taking blood samples; blood testing apparatus, namely blood analytes concentration measuring apparatus, blood gas analyzers, blood glucose meters, blood ketone monitors, blood pressure measuring apparatus; body rehabilitation apparatus for medical purposes, namely, ankle supports, back supports, crutches, supporting bandage slings, walking frames for disabled persons, radiological equipment for medical purposes; Massage apparatus, namely facial massagers, massage gloves, vibrator massagers; Physiotherapy apparatus, namely gymnastic mats, balance platforms, examination tables; physiotherapy apparatus namely, shoulder wheels, parallel bars and stairs for building strength, balance and stamina; physiotherapeutic functional movement therapy apparatus for gait therapy, balance therapy, hip therapy, knee therapy, ankle therapy, cardiovascular therapy, cognitive therapy, arm and hand therapy, namely, kinesiology tapes for physiotherapy purposes, manually-operated resistance bands for physical therapy purposes, manually-operated resistance tubing for physical therapy purposes; medical respirators; Gloves for medical purposes; Sanitary masks for medical purposes; Non-woven textile fabrics surgical drapes; Masks for use by medical personnel
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Dietary supplements for general health and well-being; vitamin and mineral supplements; Dietary supplements consisting of amino acids, minerals and trace elements; Dietetic foods adapted for treating and preventing insomnia; dietetic foods for treating and preventing conditions associated with high blood lipid levels or high blood sugar; dietetic foods used to combat the effects of fatigue and tiredness and to promote and stimulate physical and mental alertness; nutritional supplement for eliminating toxins from the intestinal tract; Dietetic substances, namely, dietetic substances containing vitamins, minerals, amino acids and trace elements for medical and clinical purposes; dietetic beverages for weight loss, dietetic beverages for muscle retention, dietetic beverages to aid recovery after exercise; nutritional supplements for general health and well-being; nutritional supplements for building body mass; Mineral food supplements; Vitamin preparations; Herbal tonics for energy enhancement; Medicines for human purposes, namely pain relief medicine, medicines for the treatment of cardiovascular, cardiopulmonary, sexual dysfunction, oncological, hepatological, ophthalmic, respiratory and gastrointestinal related diseases and disorders and medicines for the treatment of viral, metabolic, endocrine, musculoskeletal, genitourinary, neurological, hormonal, dermatological, psychiatric and immune system related diseases and disorders, namely, bacterial skin infections, fungal skin infections, viral skin infections, influenza, diabetes, hypoglycaemia, gout, osteoarthritis, muscular dystrophy, anemia, growth and thyroid disorders, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, urological diseases, muscle aches, nasal congestion, cough, headache, sore throat, infertility, sexually transmitted diseases, inflammatory pelvic disease, Alzheimer's, Huntington's disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, hormonal disorders, dermatitis, skin pigmentation, anxiety, mood disorders, schizophrenia, cognitive and bipolar diseases, Parkinson's disease, multiple sclerosis, autoimmune diseases and immunologic deficiency syndromes; Medicinal drinks, namely electrolyte drinks for medicinal purposes; Pharmaceutical preparations for the treatment of infectious diseases, namely respiratory infections, respiratory system diseases, namely acute upper respiratory tract infection, acute tracheitis and bronchitis, chronic bronchitis, acute and chronic laryngopharyngitis, acute and chronic tonsillitis; Drugs for medical purposes, namely antipyretic drugs with sedative effect, antiepileptic drugs, antiarrhythmic drugs, antitumour drugs; Chemical preparations for pharmaceutical and medical purposes, namely for the treatment of cardiovascular, cardiopulmonary, sexual dysfunction, oncological, hepatological, ophthalmic, respiratory, and gastrointestinal related diseases and disorders and chemical preparations for pharmaceutical or medical purposes, namely, for the treatment of viral, metabolic, endocrine, musculoskeletal, genitourinary, neurological, hormonal, dermatological, psychiatric and immune system related diseases and disorders, namely, bacterial skin infections, fungal skin infections, viral skin infections, diabetes, hypoglycaemia, gout, osteoarthritis, muscular dystrophy, anemia, growth and thyroid disorders, connective tissue diseases, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic disease, Alzheimer's, Huntington's disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, hormonal disorders, dermatitis, skin pigmentation, anxiety, mood disorders, schizophrenia, cognitive and bipolar diseases, Parkinson's disease, multiple sclerosis, autoimmune diseases and immunologic deficiency syndromes; Antibiotics; Medicinal herbs in dried and preserved form used for promoting blood flow and general well-being; Biochemical medicines for treatment of pneumonia, hospital acquired pneumonia, urinary tract infection, gynecological infections, endometritis, pelvic inflammation, skin and skin structure infections, meningitis, and septicemia; hypolipidemic agents for reducing the level of lipids and lipoproteins in the blood; allergy relief medication; biopharmaceuticals for the treatment of cancer; Pharmaceuticals, medical and veterinary preparations for the relief of pain; Chinese traditional medicinal herbs for the treatment of colds and flu; Nutraceutical preparations for therapeutic and medical purposes, namely for the reduction of blood sugar levels, nutraceutical for the reduction of high cholesterol and nutraceutical for the treatment of cardiovascular conditions, nutraceutical for the treatment of insomnia and depression
Soporific pillows for insomnia; diagnostic apparatus for medical purposes; medical apparatus and instruments; massage apparatus; physiotherapy apparatus; respirators for medical purposes; gloves for medical purposes; sanitary masks for medical purposes; Medical drapes of non-woven textile materials; masks for use by medical personnel; Mittens for medical use.
Soporific pillows for insomnia; massage apparatus for medical purposes; respirators for artificial respiration; gloves for medical purposes; sanitary masks for medical purposes; surgical drapes; masks for use by medical personnel
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceuticals; Medical preparations; veterinary preparations; Chemico-pharmaceutical preparations; Dietetic foods adapted for medical purposes; Dietetic substances adapted for medical use; Dietetic beverages adapted for medical purposes; Nutritional supplements; Mineral food supplements; Vitamin preparations; Tonics [medicines]; Medicines for human purposes; Medicinal drinks; Cardiovascular drugs used in treating congestive heart failure (CHF); Preparations for treating colds; Antipyretic preparations; Antibiotics; Allergy relief medication; Hypolipidemic agents; Biopharmaceuticals for the treatment of cancer; Plant and herb extracts for medicinal use; Medicinal herbs; Chinese traditional medicinal herbs; anti-oxidants obtained from herbal sources; Nutraceutical preparations for therapeutic or medical purposes.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Medicine, health care products, namely, dietetic foods adapted for medical purposes, dietetic preparations adapted for medical use, dietetic beverages adapted for medical purposes, nutritional supplements, dietary supplements, mineral food supplements, tonics, namely, liquid nutritional supplements
70.
APPLICATION OF CORTEX PERIPLOCAE EXTRACT IN PREPARATION OF MEDICAMENT FOR TREATING HEART FAILURE COMPLICATIONS
An application of a cortex periplocae extract in the preparation of a medicament for treating heart failure complications. The content of periplocin in the cortex periplocae extract is >99%, which may treat heart failure and atrial fibrillation.
A61K 36/27 - Asclepiadaceae (Milkweed family), e.g. hoya
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
The present invention involves the application of Semen Ziziphi Spinosae oil in the preparation of drugs for treating medicinal insomnia. Semen Ziziphi Spinosae oil has a therapeutic effect on insomnia caused by ephedrine, prednisone and other drugs, and Semen Ziziphi Spinosae oil that is prepared within the pressing temperature of 80 to 100° C. has the best efficacy for treating medicinal insomnia.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
72.
DETECTION METHOD FOR CHINESE MEDICINE COMPOSITION BASED ON INHIBITION OF COX-2 ACTIVITY
A detection method for a Chinese medicine composition. The method uses an inhibition ratio on COX-2 enzyme of the Chinese medicine composition as a determination index to detect anti-inflammatory activity thereof. The method comprises: A) preparing a Chinese medicine composition sample solution and/or a control solution; B) determining inhibition ratios on COX-2 enzyme activity of the sample solution and the control solution; and C) calculating potency and percentage fiducial limits using the inhibition ratios on COX-2 enzyme activity as indices.
Disclosed is a method for detecting a traditional Chinese medicine composition, wherein the method uses the inhibitory effect of the traditional Chinese medicine composition on an inflammatory factor IL-6 as a detection index for detecting the anti-inflammatory activity thereof. The method comprises: A) preparing a sample solution of the traditional Chinese medicine composition and a control solution; B) detecting the inhibition rates of the inflammatory factor IL-6 by the sample solution and the control solution; and C) calculating the potency and confidence-limit rate, with the inhibition rate of the inflammatory factor IL-6 as an index.
The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among components of a compound medicine, systematic researches on the material basis is very necessary. Accordingly, deep researches are done on chemical components of the pharmaceutical composition in the solution, and eight compounds are separated, which are 10-O-(p-hydroxycinnamoyl)-adoxosidic acid, aloe-emodin-8-O-ß-D-glucopyranoside, quercitrin, matairesinol-4'-O-glucoside, liquiritin apioside, epi-vogeloside, vogeloside and ethyl caffeate, which provides a new quality control method for the composition in the solution.
The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among components of a compound medicine, systematic researches on the material basis is very necessary. Accordingly, deep researches are done on chemical components of the pharmaceutical composition in the solution, and eight compounds are separated, which are 10-O-(p-hydroxycinnamoyl)-adoxosidic acid, aloe-emodin-8-O-β-D-glucopyranoside, quercitrin, matairesinol-4'-O-glucoside, liquiritin apioside, epi-vogeloside, vogeloside and ethyl caffeate, which provides a new quality control method for the composition in the solution.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the treatment of heart disease; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for maintaining normal blood pressure and heart function; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the treatment of liver cancer; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for the treatment of liver cancer; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the treatment of heart disease; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for maintaining normal blood pressure and heart function; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the treatment of hypertension and heart disease; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for maintaining normal blood pressure and heart function; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the prevention and treatment of influenza; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for the prevention and treatment of influenza; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the treatment of benign prostatic hyperplasia; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for the treatment of benign prostatic hyperplasia; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Medicines for the treatment of gastrointestinal diseases; tonic medicines being Chinese traditional medicinal herbs used for the treatment of diabetes; vitamin supplement patches; dietary fibre for use as an ingredient in the manufacture of dietary supplements; dietetic sugar for medical use; dietetic food adapted for medical purposes for the treatment of diabetes; electrolyte drinks for medical purposes; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; vitamin and mineral food supplements; nutritional supplements for general health and well-being.
83.
TRADITIONAL CHINESE MEDICINE COMPOSITION GAS CHROMATOGRAPHY TESTING METHOD
A traditional Chinese medicine composition gas chromatography testing method, in the technical field of traditional Chinese medicine, directed toward volatile components thereof, and using gas chromatography (GC) to quantitatively determine key representative chemical components in a preparation. The testing method uses gas chromatography, a heating procedure being: an initial column temperature being 150°-180°C, maintaining for 3-10 min, then heating to 200°-210°C at a rate of 5°-15°C/min, and maintaining for 3-10 min. The present gas chromatography testing method can implement determination of volatile component content in a preparation, and rapidly analyze a traditional Chinese medicine composition preparation by means of multicomponent chemistry so as to evaluate quality thereof.
An ultra-high-performance liquid chromatography detection method for a traditional Chinese medicine (TCM) composition. The detection method comprises the following steps: step A, preparation of a test sample solution: collecting the content of a TCM composition capsule and adding an organic solvent for extraction so as to obtain the test sample solution; step B, preparation of a control solution: collecting chlorogenic acid, caffeic acid, rutin, isochlorogenic acid B, isochlorogenic acid C, forsythiaside A and forsythin and adding an organic solvent to dissolve so as to obtain the control solution; and step C, detection: using ultra-high-performance liquid chromatography with methanol (A) and water containing phosphate (B) as mobile phases for gradient elution. The ultra-high-performance liquid chromatography can quantitatively determine seven chemical components in a composition, such that the quality of the composition is evaluated by means of said fast multi-component chemical analysis, thereby achieving better characterization of quality differences between batches of TCM composition capsules.
The invention belongs to the field of quality analysis and control of traditional Chinese medicine, and provides a method for separating eighteen components in a traditional Chinese medicine composition, comprising: (1) preparing the traditional Chinese medicine composition into a total extract of the traditional Chinese medicine composition, separating by resin through sequentially eluting with water, 10% ethanol and 30% ethanol, and collecting the 30% ethanol eluate to obtain a 30% ethanol extract; (2) adding the 30% ethanol extract to a reverse phase silica gel ODS-AQ-HG, and separating in a medium pressure separation column to obtain differently numbered elution dry pastes; (3) dissolving the differently numbered elution dry paste with 30% methanol as a solvent, and passing the solution through a 0.45 μm microporous membrane, carrying out a primary separation by high performance liquid chromatography and collecting chromatographic peaks with different retention times, and further purifying by high performance liquid chromatography; finally obtaining the compounds of eighteen components. The separation method of the present invention enables in-depth study of the chemical components of a pharmaceutical composition.
C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
C07C 45/78 - SeparationPurificationStabilisationUse of additives
C07C 47/565 - Compounds having —CHO groups bound to carbon atoms of six-membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
C07C 67/48 - SeparationPurificationStabilisationUse of additives
Disclosed are an FLZ crystal B form, a preparation method, and a composition and the use thereof, in particular the crystal B form of an FLZ compound (I) (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl-ethyl)acrylamide), a preparation method therefor, and the composition and the use thereof. In particular, disclosed are the crystal B form solid matter of FLZ in a solid state; the method for preparing the crystal B form solid matter; and the use of the FLZ crystal B form solid matter as a pharmaceutically active ingredient in the preparation of a preventive drug for resisting Parkinson's disease (PD), improving learning and memory disorders, treating memory ability decline and Alzheimer's disease (AD).
C07C 233/17 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
C07C 233/01 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 235/34 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Disclosed are an FLZ crystal G form, a preparation method, and a composition and the use thereof, in particular the crystal G form of an FLZ compound (I) (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl-ethyl)acrylamide), a preparation method therefor, and the composition and the use thereof. In particular, disclosed are the crystal G form solid matter of FLZ in a solid state; the preparation method for the crystal G form solid matter; and the use of the FLZ crystal G form solid matter as a pharmaceutically active ingredient in the preparation of a preventive drug for resisting Parkinson's disease (PD), improving learning and memory disorders, treating memory ability decline and Alzheimer's disease (AD).
C07C 235/34 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
Disclosed is a method for determining the content of menthol in a traditional Chinese medicine composition. The traditional Chinese medicine composition consists of the following medical materials: forsythia, honeysuckle, Radix isatidis, Semen armeniacae amarum, menthol, Herba houttuyniae, rhubarb, Pogostemon cablin, Rhizoma dryopteris crassirhizomae, rhodiola, ephedra, Radix glycyrrhizae and gypsum. The content determination method uses gas chromatography to determine the content of the menthol in the formula, and can effectively control the content of the menthol in the formula, and the method can save energy and reduce analytical costs.
Disclosed is a method for determining the content of menthol in a traditional Chinese medicine composition. The traditional Chinese medicine composition consists of the following medical materials: forsythia, honeysuckle, Radix isatidis, Semen armeniacae amarum, menthol, Herba houttuyniae, rhubarb, Pogostemon cablin, Rhizoma dryopteris crassirhizomae, rhodiola, ephedra, Radix glycyrrhizae and gypsum. The content determination method uses gas chromatography to determine the content of the menthol in the formula, and can effectively control the content of the menthol in the formula, and the method can save energy and reduce analytical costs.
Applications of jujube seed oil in the preparation of drugs for treating medicinal insomnia. The jujube seed oil has treatment effects on insomnia caused by ephedrine, prednisone and other drugs, and especially the jujube seed oil having a pressing temperature ranging from 80ºC to 100ºC has the optimal effect on the medicinal insomnia.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
91.
METHOD FOR DETERMINING COMPONENT CONTENTS OF CHINESE MEDICINE COMPOSITION
Provided is a method for determining the component contents of a Chinese medicine composition. Raw materials for the Chinese medicine composition consist of forsythia, Japanese honeysuckle, indigowoad root, bitter almond, mentha-camphor, houttuynia cordata, rhubarb, patchouli, male fern rhizome, kirilow rhodiola root and rhizome, ephedra, licorice, and gypsum. The component content determination method uses a high-performance liquid chromatography technique to simultaneously determine the contents of seven components: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoforsythiaside A, 4,5-di-O-caffeoylquinic acid, quercitrin, and glycyrrhizic acid ammonium salt. A test sample is extracted by methanol or ethanol. The chromatographic conditions comprise using a methanol/acetonitrile/0.1-0.5% phosphoric acid aqueous solution as a mobile phase to perform a gradient elution, and using two detection wavelengths of 327 nm and 250 nm.
Provided is a method for determining a high-performance liquid chromatographic fingerprint of a Chinese medicine composition. The Chinese medicine composition consists of forsythia, Japanese honeysuckle, indigowoad root, bitter almond, mentha-camphor, houttuynia cordata, rhubarb, patchouli, male fern rhizome, kirilow rhodiola root and rhizome, ephedra, licorice, and gypsum. The fingerprint determination method detects 15 main chromatographic peaks, and identifies nine of the main chromatographic peaks as neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoforsythiaside A, forsythiaside A, forsythin, quercitrin, 4,5-di-O-caffeoylquinic acid, and glycyrrhizic acid ammonium salt, respectively.
The present invention provides a Taccalonolide compound cyclodextrin inclusion compound. A molar ratio of a Taccalonolide compound to cyclodextrin is 1:(3-100). By means of inclusion of the Taccalonolide compound and the cyclodextrin, a Taccalonolide compound cyclodextrin inclusion compound is obtained, such that the present invention greatly improves the water solubility and stability of the Taccalonolide compound, and has a stronger inhibiting effect on the proliferative activity of tumor cells.
Disclosed are a solid beverage containing ginseng and the preparation method thereof. The solid beverage is composed of the following raw materials in parts by weight: 10-15 parts of ginseng, 3-7 parts of pumpkin powder, 8-12 parts of fructose, 8-16 parts of resistant dextrin, 50-80 parts of erythritol, 2-6 parts of pectin, and 0.05-0.2 parts of ginseng flavouring. The preparation method thereof comprises the following steps: the ginseng is extracted with water, filtered, dried under a reduced pressure after concentration, and the obtained dry paste is pulverized and the prepared ginseng powder is used in the following steps; sieved pumpkin powder, pectin, fructose, erythritol and resistant dextrin are added to the above-mentioned ginseng powder and mixed, then spraying into said mixture the ginseng flavouring once said flavouring is dissolved by means of a wetting agent, and thus the mixed powder is obtained; and the mixed powder is granulated, sieved, dried and sized, and dry particles are obtained. The beverage has a pleasant fragrance and its taste is sour, sweet and tasty.
Disclosed are a solid beverage containing honeysuckle and a preparation method thereof. The solid beverage consists of honeysuckle, boat-fruited scaphium seeds, Platycodon grandiflorum, lemon powder and other major components. The preparation method comprises the steps of water extraction, sieved mixing, granulation, packaging and inspection. Through reasonable compatibility and scientific preparation, the product has a pleasant aroma, sweet and sour taste, was well praised by the majority of the trial crowd, is easy to carry, and reasonably supplements a variety of vitamins and trace elements which the human body needs.
Disclosed are a solid beverage containing rhizoma polygonati and a preparation method thereof. The solid beverage consists of the following raw materials in parts by weight: 5-9 parts of rhizoma polygonati, 1-5 parts of mulberry leaves, 60-90 parts of erythritol, 0.1-0.3 parts of neotame, 15-20 parts of resistant dextrin, and 0.3-0.6 parts of citric acid. The preparation method comprises the following steps: the mulberry leaves are extracted with water, filtered, and dried before pulverizing to obtain a dry cream powder for use; the rhizoma polygonati is extracted with water, filtered, and concentrated to obtain the concentrated liquid for use; the erythritol, resistant dextrin, citric acid, neotame and mulberry leaf extracts are mixed homogeneously to obtain the mixed powder for use; the mixed powder is wet granulated, and the extract liquid of the rhizoma polygonati is sprayed into same, sieved, dried and granulated to obtain dry granules. The solid beverage has a pleasant aroma, and a sweet and sour taste.
The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use thereof. The pyrrole-substituted indolone derivative has a structure shown in formula (I) below. The present invention further relates to use of the pyrrole-substituted indolone derivative for treating receptor tyrosine kinase-mediated diseases, and to a pharmaceutical composition comprising compounds having such a structure for treating related diseases such as tumors.
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising same and a use thereof. The pyrrole-substituted indolone derivative has a structure represented by general formula (I). The present invention further relates to a use of the pyrrole-substituted indolone derivative in treating receptor tyrosine kinase mediated diseases and a pharmaceutical composition containing a compound of such structure for treating diseases related to tumor and the like.
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising the derivative, and use thereof. The pyrrole-substituted indolone derivative has a structure shown in formula (I) below. The present invention further relates to use of the pyrrole-substituted indolone derivative for treating receptor tyrosine kinase-mediated diseases, and to a pharmaceutical composition comprising compounds having such a structure for treating related diseases such as tumors. (see formula I)
C07D 401/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
100.
Derivative of butylphthalide and preparation method and use thereof
(−)-(S)-3-(3′-hydroxy)-butylphthalide (a compound shown by Formula I) and an ester formed of the same and an acid are proved by experiments to be applicable to treatment and prevention of cerebral ischemic diseases and have a sleep-improving function. The acid refers to a pharmaceutically acceptable inorganic or organic acid. The inorganic acid refers to nitric acid, sulfuric acid, or phosphoric acid. In addition to an acid radical, the organic acid at least comprises at least one of an amino group, a hydroxyl group, and a carboxyl group. None of the compound shown by Formula I and the ester thereof is water-soluble. An ester generated from the compound and the acid further react with an acid or a base to generate a salt which is water-soluble and is used to prepare injection preparation. The experiment proves that the salt does not stimulate vessels.
C07D 307/88 - Benzo [c] furansHydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
C07F 9/655 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
