A method of providing a drainage catheter comprising multiple drainage conduits is provided. The method includes introducing a director rod into a lumen of a catheter main body. The catheter main body includes multiple fenestrations that are arranged along a distal length of the catheter main body. A drainage tube limb is pushed around and over the director rod and through the lumen of the catheter main body. The director rod guides the drainage tube limb toward a preselected fenestration. The drainage tube limb is pushed through the preselected fenestration.
An apparatus for temporarily limiting blood flow to heart uses balloon-based technologies to vary a diameter of the outflow aperture of an associated vessel. Related methods are also disclosed.
A catheter assembly for removal of material from hollow bodies may include an outer sheath, and an inner thrombectomy catheter disposed inside of the outer sheath. The inner thrombectomy catheter may include a distal end and a conveyer. The distal end may include a distal tip being closed and a lateral opening such that the lateral opening receives a removed material. The conveyer may convey the removed material toward a proximal end of the inner thrombectomy catheter. An expandable member may be disposed between the outer sheath and the inner thrombectomy catheter. The expandable member may expand radially when deployed from the outer sheath and contract when retracted in the outer sheath.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
The present disclosure relates to catheters for use in removing an occlusion in a vessel. The catheter includes a cannula with a sidewall that defines a cannula lumen, and a distal portion, disposed at a distal end of the cannula, with a body that defines a body lumen. The catheter also includes a helix member that is rotatably disposed, at least partially, in the cannula lumen and body lumen. A longitudinally-oriented blade is attached to the helix member and at least a portion of the blade is intermittently exposed at the lateral opening. In operation, catheters according to the present disclosure generate negative pressure, which aspirates the occlusive material from the vessel through the catheter. In embodiments, while the occlusive material is being aspirated, the catheter causes the occlusive material to contact the clot fragmentation components, causing the occlusive material to break into smaller fragments.
Assemblies and methods of use of an biopsy cannula ejection system including a biopsy cannula defining a lumen, an adapter configured to be coupled to the lumen of the biopsy cannula, and an ejector rod are directed to advancement of the ejector rod through the biopsy cannula. The ejector rod may include a threaded ejector component and a rod component. The threaded ejector component may include ejector threads, the rod component coupled to and extending from the threaded ejector component. The adapter is configured to be rotatably attached to the threaded ejector component, and the rod component of the ejector rod is configured to be inserted through the adapter until the threaded ejector component interfaces with the adapter such that the ejector threads are received by the adapter threads. Rotation of the threaded ejector component with respect to the adapter advances the rod component.
A device, system, and method for drainage of fluid. The system may include a pump with a motor, an interface for controlling operation of the motor, and one more roller for occluding or partially occluding tubing wherein the motor is operatively connected to a one or more rollers. The system may further include tubing set for draining the fluid from a catheter with a pumping portion configured to be occluded or partially occluded by the one or more rollers to pump fluid through the tubing from a tubing inlet portion to a tubing outlet portion, the tubing set comprising tubing guide, wherein the tubing guide is configured to be removably connected to the pump and contain the pumping portion of the tubing set.
F04B 43/12 - Machines, pumps, or pumping installations having flexible working members having peristaltic action
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
7.
CATHETER ASSEMBLIES HAVING A DILATABLE RETRIEVAL BASKET AND METHODS OF USE
A catheter assembly for performing a thrombectomy and methods of use, the catheter assembly including a catheter sheath and a dilation and capture assembly slidably positioned within the catheter sheath. The dilation and capture assembly includes a catheter having a balloon portion at a distal end of the catheter, and a retrieval basket. The balloon portion is selectively inflatable and deflatable between respectively a maceration orientation and a delivery orientation. The retrieval basket is deployable from a delivery configuration mounted to the balloon portion and a retrieving configuration axially displaced from the distal end of the catheter.
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
An endovascular device is described herein. The endovascular device may be utilized for a variety of treatments, for example, treating May Thurner Syndrome. The endovascular device includes a catheter, a needle extending within a lumen of the catheter, and a shaving mechanism at least partially arranged within a lumen of the needle. The needle is movable within the catheter, and distal movement of the needle advances a distal needle tip of the needle out of the catheter and proximal movement of the needle retracts the distal needle tip within the lumen of the catheter. The shaving mechanism includes an abrasive burr positioned proximate the distal needle tip, wherein the abrasive burr is rotatable relative to the needle upon activation of the shaving mechanism.
A venous thrombectomy device includes a net assembly and a dislodger assembly that are operated independent of each other. The net assembly includes a wire and an expandable net secured at a distal end of the wire, wherein, when in an expanded state, the expandable net defines an interior collection volume with a mouth that opens proximally when the net is advanced distally beyond the thrombus and expanded. The dislodger assembly includes at least one node secured at a distal end of a shaft, wherein the wire of the net assembly extends through a lumen of the shaft such that the dislodger assembly may translate axially over and rotate about the wire, relative to the net.
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
Provided herein are embolic hydrogels for use in methods of female sterilization. An embolic hydrogel may include a maleimide or a maleimide derivative. The embolic hydrogel is administered to a fallopian tube wall, wherein the fallopian tube wall comprises a thiol functional group, said functional group forming a linker moiety between the fallopian tube wall and the maleimide or maleimide derivative, whereby the linker moiety covalently links the embolic hydrogel to the fallopian tube wall.
Assemblies and methods of use of a delivery assembly may include a console including a sled containment region, a sled assembly slidably couplable to the sled containment region of the console. The sled assembly may be configured to extend between an open position and a closed position. The sled assembly may be housed within the sled containment region in the closed position and the sled assembly extending from the sled containment region in the open position may be configured to receive a tubing set including one or more tubing in the open position. An aperture of a plurality of apertures of a front wall of the sled assembly may be configured to receive a tubing segment of the one or more tubing of the tubing set, the tubing segment configured to connect to a delivery line, the delivery line configured to deliver a particulate via the delivery assembly.
Provided herein are compositions for use in forming temporary occlusion of a target site and methods of making same. The compositions disclosed herein include rare-earth phosphates compositions for temporary occlusion of a target sites. The compositions can be used in a variety of medical indications, such as trauma, ambulatory transport, to prevent and/or control bleeding (e.g., organ bleeding, gastrointestinal bleeding, vascular bleeding, bleeding associated with an aneurysm, etc.).
Embodiments herein are directed to a tissue sampling device. The tissue sampling device includes a housing and a sub-frame positioned within the housing. A stylet hub is movably coupled to the sub-frame and has an outer surface and a resilient member extending from the outer surface. The resilient member is configured to transition between an unflexed state and a flexed state. The stylet hub is movable between a cocked position and an activated position along a central axis with respect to the sub-frame. A cannula hub is movably coupled to the sub-frame and movable between the cocked position the activated position the central axis with respect to the sub-frame. The resilient member is actuated between the flexed state and the unflexed state when the resilient member is in contact with a portion of the sub-frame as a function of a kinetic energy input exerted on the resilient member.
A monitoring system is provided. The monitoring system includes a controller and either a shunt device, an externally-communicating catheter, and/or a fluid retention device. The shunt device and catheter are configured to address fluid movement such as ascites and pleural effusions. Each of the shunt device and catheter include a plurality of sensors that communicate with the controller positioned external to a body of a subject. The plurality of sensors are configured to output a signal indicative of a total volume, a glucose amount, or an oxygenation within a fluid flowing in contact within or surrounding the shunt device or the catheter.
A medical sealant applicator device for delivery of a multi-component sealant including a first body having a base, a first syringe plunger, a second syringe plunger, and a longitudinal channel, laterally interposed between the first syringe plunger and the second syringe plunger. Each of the first syringe plunger and the second syringe plunger is oriented to extend in a first direction from the base. The first syringe plunger has a first free end having a first proximal plunger piston. The second syringe plunger having a second free end having a second proximal plunger piston. A second body of the medical sealant application device has a first syringe chamber, a second syringe chamber, and a longitudinal fluid chamber laterally interposed between the first syringe chamber and the second syringe chamber. The longitudinal fluid chamber has a proximal end and a distal end.
Methods of modifying the envelope density of therapeutic microspheres can provide therapeutic microspheres for optimal distribution to different targets of therapy. For example, a method of modifying an envelope density of therapeutic microspheres can include electroplating bare microspheres with one or more layers of metal to provide densified microspheres. Surfaces of the densified microspheres can include the one-or-more layers of metal thereover while at least partially maintaining pore structure and availability for loading a therapeutic agent therein. An increase in mass from the one-or-more layers of metal and any loss of the pore structure in densified microspheres can contribute to an increase in the envelope density. The method can also include loading the therapeutic agent into pores of the densified microspheres, thereby providing the therapeutic microspheres for the optimal distribution to one or more targets of therapy.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
An apparatus for engaging a thrombus in a vessel includes a catheter having a first expandable element. A plurality of scrapers attached at a distal end portion to the catheter extend proximally at least partially alongside the first expandable element. In one embodiment, a proximal end portion of the plurality of scrapers is unattached to the catheter and adapted to be inserted between the thrombus and the vessel. Additional embodiments and related methods are also disclosed.
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
The present disclosure relates to a scoping device equipped with an inflatable balloon. Connected to the exterior of the balloon are one or more cables that are threaded through at least a part of the scoping device and are available to a user to apply a pulling force thereon. Such force can then allow the balloon to rotate or move across a desired area of tissue within a subject. The presence of a coating layer on the exterior of the balloon allows for the same to be site-specifically delivered. The present device therefore allows for site specific delivery of one or more therapeutics through a scoping device.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/018 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
Embodiments disclosed herein are directed to a prosthesis defining a lumen and including a graft disposed on an outer surface, and a triboelectric nano-generator (TENG) coupled to an inner surface thereof. The TENG can move relative to prosthesis in one of a rotational, radial, or linear movement. The TENG can be coupled to the prosthesis at the upstream and downstream ends to define an air gap therebetween. The TENG can be formed of a first material (e.g. polytetrafluoroethylene, PTFE), the graft can be formed of a second material (e.g. polycarbonate, nylon, LDPE, HOPE). The difference in charge affinity can create a voltage output as the TENG is moved by blood flowing through the lumen. The voltage output can be communicated to a console to determine blood flow information and determine the onset or rate of restenosis.
Certain aspects of the present disclosure provide for a biopsy device. The biopsy device includes a probe defining a sample notch for collecting a tissue sample and a coolant chamber. The coolant chamber positioned adjacent to the sample notch and configured to be fluidically coupled to a coolant source. The coolant chamber and the sample notch being fluidically isolated from one another during collection of the tissue sample.
A61B 10/02 - Instruments for taking cell samples or for biopsy
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
Disclosed herein is a blood flow restriction device, that includes an elongate member configured for advancement along a blood vessel, having an actuator at a proximal end and a restriction mechanism at a distal end. The restriction mechanism is configured to transition between a various states of blood-flow restriction that includes deploying and/or retracting one or more restriction members between a collapsed state and a distally expanded state by the actuator. One or more restriction members may be cone shaped having conical wall which may include a number of apertures extending therethrough. The restriction mechanism may be transitionable either discreetly or variably between two or more blood-flow restriction states. The actuator may include a microprocessor controlled electro-mechanical actuator coupled with a sensor configured to measure a blood flow parameter, and logic of the controller may adjust a blood flow restriction amount based on a signal from the sensor.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61M 25/06 - Body-piercing guide needles or the like
22.
COMPOSITIONS AND METHODS FOR VASCULAR STABILIZATION
Compositions and methods stabilize existing or imparted vascular states of blood vessels. In an example, a composition for vascular stabilization can include a crosslink breaker, a protein denaturant, a crosslinking agent, or some combination thereof provided the composition includes at least the crosslink breaker or the protein denaturant if the composition includes the crosslinking agent. The crosslink breaker breaks existing protein crosslinks in a luminal wall of a blood vessel. The protein denaturant denatures proteins in the luminal wall of the blood vessel. The crosslinking agent establishes new protein crosslinks in the luminal wall of the blood vessel. The composition can be formulated into a formulation for direct administration to the luminal wall of the blood vessel by an intravascular medical device to stabilize an existing vascular state of the blood vessel or an imparted vascular state of the blood vessel.
A catheter includes a first lumen enclosed by a first outer wall forming a first side of the catheter and a second lumen enclosed by a second outer wall forming a second side of the catheter. Each of the first side and the second side of the catheter can be formed of a first material. The catheter further includes a septum laterally connecting the first side to the second side. The septum can include a wire extending longitudinally parallel to the first lumen and the second lumen. The wire can be urged transversely through the septum to separate the first side of the catheter from the second side of the catheter along a separation length. The separation length can be along a proximal portion. The first side and the second side of the catheter can be trimmed to different lengths and attached to first and second subcutaneous access devices, respectively.
A surgical guidewire and snare apparatus comprising of an elongated sheath that has a central, longitudinal bore, proximal and distal sheath ends. A head is at the sheath distal end. A wire or cable occupies the central, longitudinal bore, and the wire or cable has a proximal wire or cable and a distal wire or cable end. The wire or cable distal end has an engagement with the head. Slotted portions are on the sheath at the sheath distal end. Spaced apart sections of the sheath are next to the slotted portions. Tension is applied to the wire or cable proximal end that pulls the head proximally to enlarge the slotted portions and curve the spaced apart sheath sections next to the slotted portions.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A rotational atherectomy device includes an elongate flexible shaft and an abrasive element connected to a distal end of the elongate flexible shaft. A handle includes a housing that includes an electric motor operatively connected to the elongate flexible shaft to rotate the elongate flexible shaft. A power source is electrically connected to the electric motor for supplying power thereto. A controller is configured to monitor a motor supply current of the electric motor and monitor a speed of the electric motor using a signal from a sensor. If the motor supply current is above a first predetermined threshold, the controller reduces a speed of the electric motor while attempting to maintain motor supply current of the electric motor. Then, if the motor supply current is above a second predetermined threshold higher than the first predetermined threshold, the controller stops the electric motor.
Disclosed herein are devices for delivering a marker includes a reusable handle assembly including a handle body defining a body passage extending between an inlet and an outlet, a first key slot, and a second key slot positioned distally to the first key slot. An ejector body is configured to be received within the body passage of the handle body, the ejector body including a head portion and a shank portion coupled to the head portion, the shank portion including at least one key sized to pass through the first key slot and the second key slot. A delivery cannula is configured to be coupled to the handle body at the outlet, and a pusher rod is configured to be coupled to the ejector body and pushed through the delivery cannula to deliver a marker.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
27.
CATHETERS, DEVICES, AND METHODS FOR REMOVING MATERIALS FROM HOLLOW BODIES
A catheter for removal of material from hollow bodies is provided. The catheter may include a catheter body defining an opening and a cutting ribbon extending around the catheter body. The cutting ribbon extends out of the opening of the catheter body and has an expanded configuration having a relatively large hoop size and a retracted configuration having a relatively small hoop size. The cutting ribbon includes an elongated ribbon body, and a blade disposed at a side edge of the ribbon body.
An implantable device includes a stent that is configured to transition between a free state, a collapsed state smaller than the free state, and an expanded state larger than the free state. The stent includes an adhesive layer configured to bond the stent to the vein wall so that structure strength of the stent can upon contraction from the expanded state toward the free state reduce the diameter of the vein. The device may include a sheath covering the stent. Some adhesives may bond to bodily tissue but avoid bonding to polymeric materials. A protective layer over the adhesive layer may upon placement of the device within the vein become degraded, thereby activating the adhesive. A balloon disposed within the device may expand the device toward the expanded state. The stent may include a resorbable material.
A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61B 17/00 - Surgical instruments, devices or methods
29.
Coated Subcutaneous Access Device and Associated Methods
Embodiments disclosed herein are directed to a subcutaneous vascular access system including an access port, a catheter, and a cathlock, and including a coating disposed on a surface thereof. The coating can include a lubricious and or hydrophilic coating. The hydrophilic coating can be transitioned to an activated state by submersing the coating in a solution. The coating can be configured to reduce infection, reduce biofilm formation, and improve case of insertion. Embodiments include active ingredients formed within the coating and/or can be included within the solution to be loaded into the coating when activated. The active ingredients can be configured prevent infection, prevent thrombi formation, prevent biofilm formation, or combinations thereof.
A sealant applicator comprises: two free-standing barrels formed as a single component attached at a distal end and a proximal end, wherein: each free-standing barrel comprises a respective barrel chamber, each barrel chamber comprises at least one output port and at least one input opening, and the proximal end comprises a first protrusion and a lateral protrusion, wherein at least one interior rib extends at least partially along a protrusion axis; and a connector disposed on the distal end of the two free-standing barrels adjacent to the at least one output port of each barrel chamber, the connector shaped to releasably interlock with a connector of an injection needle assembly.
A medical apparatus for performing a medical procedure in a vessel having an inner wall. The apparatus includes an inflatable balloon incorporating a pressure sensor for sensing contact between the inner wall of the vessel and the balloon when inflated. Related methods are also disclosed.
An apparatus for forming a catheter includes a catheter shaft and a hub including at least one connector for irremovably connecting the catheter shaft to the hub. The catheter shaft may engage one or more push connectors captured within a passage in the hub. Related are methods of manufacturing a catheter hub, including connecting first and second generally symmetrical halves of a hub over a connector, and then inserting a catheter shaft into the connector, such as by pushing it through a ring with inwardly directed fingers to form a secure locking engagement.
An apparatus for performing angioplasty on a lesion and applying a therapeutic agent thereto. The apparatus includes a catheter having an inflatable balloon, such as a non-compliant balloon, adapted to compress the lesion when inflated. At least one port adapted to deliver the therapeutic agent to adjacent the lesion, such as once the balloon is deflated and advanced past a location where the inflatable balloon compressed the lesion. Alternatively, one or more additional balloons, which may be compliant balloons located distally or proximally of the balloon for compressing the lesion, may be inflated to form a sealed chamber including the compressed lesion and the therapeutic agent once delivered via the at least one port. Related methods are also disclosed.
Embodiments disclosed herein are directed to an identification insert and assembly alignment feature for a subcutaneous access port. The port can include an identification insert assembled with the device and configured to be visible under medical imaging when placed subcutaneously. The insert can indicate a property of the port and a location or orientation of the port to facilitate access thereto. An alignment feature can be configured to align the insert with the port in a first orientation during manufacture. The alignment feature can also be configured to misalign the insert with the port in a second orientation, different from the first orientation. This can prevent the port from being assembled if the insert is coupled with the port incorrectly. A port having an insert assembled incorrectly can lead to unnecessary disruptions and complications to the patient to correct the problem.
A vascular implant including a tubular body of a polymeric material. The body has opposed filter body ends and a longitudinal axis. The body has a generally tubular segmented side wall that includes multiple spaced apart wall panels surrounding a central open-ended bore. The body includes one or more filtering elements in the bore and in between filter ends. One or more filtering elements including a hub at the central longitudinal axis and multiple radially extending filtering arms extend radially between the hub and wall, wherein each arm connects to a wall panel. The tubular body end has anchors that prevent migration and/or tilting.
A handle assembly for a medical device includes a proximal handle assembly that includes a proximal rotational shaft portion and a proximal magnetic disk mounted to the proximal rotational shaft portion, the proximal magnetic disk including one or more proximal interlock features. The medical device also includes a distal handle assembly that includes a distal rotational shaft portion and a distal magnetic disk mounted to the distal rotational shaft portion, the distal magnetic disk including one or more distal interlock features. The proximal magnetic disk and the distal magnetic disk interlock with one another via interaction of the one or more proximal interlock features and the one or more distal interlock features.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A biopsy device includes a reusable assembly that includes an outer housing and a plunger lock mechanism located in the outer housing. The plunger lock mechanism includes an actuation member accessible outside the outer housing that moves relative to the outer housing and includes a cam surface. A release flange is configured to move axially in the outer housing and includes a follower surface. A gripping finger is configured to move laterally with axial movement of the release flange. The cam and follower surfaces are configured to cooperate such that movement of the actuation member relative to the outer housing moves the release flange axially relative to the gripping finger. The release flange is configured to move the gripping finger from a locked configuration engaged with a plunger of a syringe to an unlocked configuration disengaged with the plunger of the syringe.
A composite medical balloon (10) includes a base balloon (100) and an outer layer (16) overlying the base balloon, the outer layer comprising a film having a single longitudinal seam (80), or a longitudinal seam facing the base balloon, such as a result of a tube including the seam being everted prior to application to the base balloon. Related methods are also disclosed.
A medical apparatus is for performing an endovascular medical procedure. The medical apparatus includes one or more barbs (30,32), which may be rigid, projecting radially outwardly relative to an outer surface of the inflatable balloon (12), such as for assisting in cracking a lesion, drug delivery, anchoring the balloon in place, or engaging and positioning an implant in a vessel. The barb(s) may be provided on an outer layer of the balloon, which may comprise a sleeve (40) into which the inflatable balloon may be inserted. The sleeve may include one or more openings (O), which may be at least partially covered by a portion of the sleeve that when deployed forms the barb. The balloon may also be adapted for delivering an agent, such as a pharmaceutical composition for enhancing the treatment, including through the one or more openings in the sleeve. Related forming methods are also disclosed.
The present disclosure concerns coatings for re-usable bronchoscopes that increase dry lubrication while also providing a bactericidal quality to allow for increased hygienic re-use. In aspects, the present disclosure concerns a titanium dioxide-polytetrafluoroethylene composite coating along the working length of the bronchoscope.
A vascular implant body having an oval shaped side wall surrounding a bore wherein the side wall has opposed curved end portions, an outer surface and an inner surface surrounding the bore. There are first and second filter openings on opposing ends of the bore. The body is sized and shaped to change the shape of the patient's vascular system at a vessel implant site and reduce the area available for emboli to pass.
Embodiments disclosed herein are directed to a cathlock system integrally formed with a port or similar access device. The cathlock mechanism can include a shroud defining a recess, a stem disposed therein, and a collet lock transitionable between an unlocked and a locked configuration. The system can further include a tool configured to engage an outer surface of the cathlock and plastically deform the collet lock into the recess to the locked configuration. The collet lock can compress the catheter onto the stem to form a fluid-tight seal therebetween. The collet lock can be configured to engage the cathlock mechanism in the open configuration to facilitate coupling the catheter with the cathlock within the confined environment of a subcutaneous placement. Embodiments can include an extension leg disposed between the port and the cathlock mechanism.
The present disclosure relates to ultrasonic catheters including vibration wires that are positionable in a retracted position and an extended position, and their methods of use. In operation, catheters according to the present disclosure are operable in an occlusion crossing mode, in which the catheter emits ultrasonic energy with the vibration wires in the retracted position and in an atherectomy mode, in which the catheter emits ultrasonic energy with the vibration wires in the extended position, causing the vibration wires to oscillate. The vibration wires may directly or indirectly engage plaque within an artery, causing the plaque to break free from the artery wall. The oscillation of the vibration wires may be less abrasive than conventional cutting elements used in atherectomy procedures, such that catheters according to the present disclosure may cause less trauma to artery walls as compared to conventional atherectomy devices.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
The present disclosure provides implantable devices and methods of using the implantable devices in a subject. The implantable devices include a permanent or semi-permanent capsule (108) detectable by an imaging modality; an oxygen generating component including a reactive oxygen species, wherein: the oxygen generating component releases the reactive oxygen species when triggered by an external stimulus.
An embolization device includes a catheter having a guidewire lumen, a proximal balloon inflation lumen, and a distal balloon inflation lumen. A proximal balloon is disposed on the catheter and is in fluid communication with the proximal balloon inflation lumen, and a distal balloon is disposed on the catheter and is in fluid communication with the distal balloon inflation lumen. A stent having a proximal stent portion, a distal stent portion, and a stent neck disposed is therebetween, the proximal stent portion being disposed over the proximal balloon and the distal stent portion being disposed over the distal balloon. The proximal balloon and the distal balloon are inflated independently via the proximal balloon inflation lumen and the distal balloon inflation lumen such that. The proximal balloon is inflated to a first diameter and the distal balloon is inflated to a second diameter.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
46.
DEVICE FOR THE REMOVAL OF AN OBSTRUCTION FROM A BLOOD VESSEL
A device for the removal of an obstruction from a blood vessel includes a shaft having a proximal end and a distal end; a substantially cylindrical expandable structure configured to expand radially outwards relative to the shaft; and an extendable seal configured to extend radially outwards relative to the expandable structure.
Embodiments disclosed herein are directed to a subcutaneous access port including an identification insert, or marker, visible under medical imaging. An outer perimeter of the marker can define an alphanumeric symbol to indicate a property of the port, further the marker can indicate a location or orientation of the port. The marker can be received within a recess, a shape of the recess is configured to receive the marker in a first orientation. In an embodiment, the shape of the marker and recess is configured to prevent the marker from engaging the recess in a second orientation. This can prevent the port from being assembled if the marker is coupled with the port incorrectly. The port can further include a cover plate to secure the marker within the recess. A bottom surface of the cover plate can align with the bottom surface of the port when engaged therewith.
Avascular implant body having opposed filter ends and a central longitudinal axis. The body having a generally tubular, segmented side wall surrounding a central open-ended bore, the side wall includes a plurality of spaced apart wall sections. There is a filtering element in the bore in between the filter ends. Each tubular body end has a barbed vessel engagement members with opposed end portions, each end portion having one or more barbs. Each vessel engagement member has a concave portion in between the end portions.
A vena cava filter apparatus, having a filter body having an upper end portion, lower end portion, and a mesh or woven or braided wall. An upper end collar is connected to the filter body upper end portion. A lower collar is connected to the filter body lower end portion, with the lower collar having an open ended bore. A cable member extends between the collars and at least through the lower collar bore, the lower collar bore having two holes of two different diameters. The cable member has a cable with a cable diameter and multiple spaced apart stops. Each stop is configured to pass through a collar bore. Each stop is configured to engage a collar, wherein when one stop engages the upper collar and a second stop engages the lower collar. The collars can be moved closer together to a deployed position.
In one embodiment, an endovascular recanalization system comprises a first catheter comprising a first catheter body and a retractable needle, wherein the retractable needle is configured to extend from a first position within the first catheter body to a second position protruding from a distal portion of the first catheter body further than in the first position; and a second catheter comprising a second catheter body defining a receiving recess for receiving the retractable needle of the first catheter.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
51.
MARKER DELIVERY ASSEMBLIES AND METHODS OF ASSEMBLING THE SAME
A marker delivery assembly includes a housing, a marker positioned within the housing, and a delivery cannula coupled to the housing distal to the marker. The marker delivery assembly also includes a pusher rod configured to extend through a proximal end of the housing to engage the marker and push the marker along the delivery cannula.
A thrombectomy device for removing a material from a subject includes a catheter, a diaphragm, and a vacuum. The catheter includes an outer body defining a lumen extending therethrough. The diaphragm is coupled to the catheter and is moveable between an open diaphragm configuration and a closed diaphragm configuration. The diaphragm allows movement of the material through the lumen when in the open diaphragm configuration and prevents movement of the material through the lumen when in the closed diaphragm configuration. The vacuum is in communication with the lumen and is operable to exert a vacuum pressure on the diaphragm. The vacuum pressure is operable to move the diaphragm from the open diaphragm configuration to the closed diaphragm configuration.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
Embodiments herein are directed to an occlusion device that includes a body, a pair of lobes, and an adjustment assembly. One of the pair of lobes positioned at a distal portion of the body and the other one is positioned at a proximal portion. The body includes an adjustment assembly positioned between the distal and the proximal portions to change a distance between the pair of lobes. The adjustment assembly includes a receiving member and an elongated member. The elongated member is configured to move the body between an extended position and a retracted position, such that in the retracted position, the elongated member is received within an inner diameter of the receiving member. In the extended position, the elongated member is extended away from a first end of the receiving member such that the distance between the pair of lobes is increased.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
54.
COIL SHAPED VEIN CLOSURE DEVICE WITH COOLING AND HEATING CAPABILITY
A medical system includes a medical device having an elongate member configured from placement within a vein experiencing chronic vein insufficiency. A sheath of the elongate member includes a temperature member extending along the sheath within a sheath lumen. The temperature member includes a coil at a distal end that is expandable to contact an inside surface of the vein. The coil transitions between a heated state and a cooled state. The coil also transitions between an expanded state extending distally beyond the sheath and a contracted state within the sheath lumen. A power source and a cooling source coupled with the coil transition the coil between the heated state and a cooled state. The sheath displaces longitudinally with respect handle to deploy and retrack coil. Cooling the coil causes vein tissue to adhere to the coil and heating the coil releases the tissue from the coil.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
Methods and use for a catheter device configured to deliver a plurality of therapeutic fluids simultaneously, in which the catheter device includes a hub, a guidewire tube extending from the hub, a plurality of fluid delivery elements extending from the hub and disposed about the guidewire tube, and a compression sheath disposable over and slidably movable relative to the plurality of fluid delivery elements. The elements are naturally biased when the compression sheath does not cover the hinge portion of each of the plurality of fluid delivery elements, and are in compressed when the compression sheath covers the hinge portion of each of the elements.
An apparatus is for forming a balloon layer, such as on an expanded base balloon. The apparatus includes a mandrel supporting the expanded base balloon. At least one gripper is provided for gripping the balloon layer, and an actuator is for stretching the balloon layer over the expanded base balloon, such as by moving the at least one gripper. Related methods for forming a balloon layer are also disclosed.
A vascular implant body having opposed filter ends and a central longitudinal axis. The implant body has a segmented side wall comprised of spaced apart wall panels that surround an open-ended bore that extends along the central longitudinal axis. Multiple filtering elements extend from a side wall to a core of the filter body, some of the filtering elements terminating at the core where they connect to another filtering element. The filtering elements can form an acute angle with the central longitudinal axis. One or more filtering elements extend from a first position on the side wall to a second position on the side wall that is spaced from the first position.
A vascular implant body having a hub or ring and having a central opening, a central longitudinal axis and an outer ring periphery. Multiple appendages each extend radially from the hub or ring. Engagement anchors on the appendages each extend outwardly toward the distal end portion of an adjacent appendage.
A connection kit system for fluidly coupling a catheter to a port may include a port having a port socket, a cathlock system including a sleeve slidably engageable with one or more connectors, a tool including a handle socket, and one or more catheters. The catheters can define different French sizes and each connector includes a stem configured to engage at least one of the catheters in an interference fit. Each connector further includes a nozzle configured to couple with either the port socket or the handle socket. Each connector includes a plurality of fingers disposed radially about the stem. The sleeve slidably engages the connector to deflect the fingers radially inwards and secure the cathlock system to the catheter. A tool facilitates coupling the cathlock system to the catheter in a confined wetted environment.
In one embodiment, a catheter for delivering an implant is provided. The catheter includes an inner shaft, an outer shaft surrounding the inner shaft, a door coupled to the inner shaft at a hinge, a biasing element biasing the door in a closed position to hold an anchor of the implant between the door and the inner shaft, and an actuation device coupled to the door and disposed between the inner shaft and the outer shaft, the actuation device configured to open the door when pulled to release the anchor from the catheter.
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
61.
CATHETER DEVICES WITH DAMPING ASSEMBLIES FOR CORE WIRES
A damping assembly for a core wire of an ultrasonic catheter assembly includes a body for receiving the core wire. The body includes a bore extending from a proximal end of the body. The bore is defined by an interior surface of the body and includes an insertion region at the proximal end and a compression region disposed distal to the insertion region. A plurality of compression members are disposed within the compression region of the bore. A retention member extends at least partially into the compression region to axially compress the plurality of compression members. The interior surface of the body defining the insertion region of the bore corresponds in shape to at least a portion of an exterior surface of the retention member to facilitate insertion of the retention member into the bore.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
A vascular implant. comprising a polymeric filter body having a central longitudinal axis and configured to be placed in a patient's blood conveying vessel portion. The filter body has a head and an outer periphery. Multiple filter legs extend both radially and longitudinally from said head. Each leg tapes between the axis and said outer periphery. Each leg has a proximal end portion next to the head and a distal portion with an anchor for engaging a vessel wall. A weakened break point is on one or more of the legs. The filter body and legs are 3D printed of a bioresorbable polymer.
A radiation shield assembly includes a radioembolization delivery device and a radiation shield. The radioembolization delivery device includes a radiation sensor, a vial assembly, a radioembolization administration set containing the vial assembly, and delivery line tubing in fluid communication with and disposed distally below the radioembolization administration set. The radiation shield includes a solid portion configured to block radiation. The solid portion includes an interior facing wall that defines an aperture. The solid portion and aperture of the radiation shield are sized such that, radiation emanating at a first angle from the radioembolization administration set and vial assembly passes through the aperture to the radiation sensor, and radiation emanating from a second angle from the delivery line tubing, the second angle distally below the first angle, is blocked by the solid portion of the radiation shield and does not pass through the aperture to the radiation sensor.
Systems and methods for operating a radioembolization device to deliver a mixed particulate may include a controller to conduct a pre-delivery measurement of radiation within a vial assembly for the radioembolization device with an onboard sensor within a window of time prior to delivery, determine and calibrate an estimated pre-delivery amount indicative of radiation in the vial assembly based on the pre-delivery measurement, display the calibrated pre-delivery amount indicative of radiation in the vial assembly on a graphical user interface communicatively coupled to the radioembolization device, and monitor delivery of the mixed particulate in the vial assembly based on display of the calibrated pre-delivery amount indicative of radiation.
Disclosed herein are devices for endovascular delivery of a tissue patch within a vessel comprising a catheter, a biasing member, a patch, and a cover. The catheter defines a lumen and an opening in communication with the lumen, the opening being positioned proximate to a distal end of the catheter. The patch disposed on the biasing member, and the cover is selectively moveable to cover the opening of the lumen. The biasing member is deployable from a compressed state, in which the biasing member and the patch are constrained within the lumen, to an expanded state wherein the biasing member expands to push the patch out of the lumen of the catheter when the cover is moved away from the opening of the lumen.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A beta radiation-resistant elastomeric article of manufacture can include an elastomeric composition resistant to beta radiation. The elastomeric composition can include a polymer blend including a first copolymer and a second copolymer, carbon-carbon crosslinks between polymer chains of the polymer blend, and at least a conductive filler. The conductive filler is in a concentration sufficient to achieve its percolation point in the elastomeric composition, thereby forming a three-dimensional conductive network throughout the elastomeric composition. The conductive network is configured to conduct beta radiation away from the carbon-carbon crosslinks for maintaining an integrity of the carbon-carbon crosslinks, thereby, conferring resistance of the elastomeric article to the beta radiation. Such an elastomeric article can be made by mixing compounding ingredients of an elastomeric formulation in an internal mixer, discharging a nascent elastomeric composition from the internal mixer, and molding the article in a mold with heat, pressure or both to establish the carbon-carbon crosslinks and the conductive network therearound.
Radioembolization pressure systems and methods include a strain gage pressure cuff and a compliant tubing, the strain gage pressure cuff configured to be disposed about a compliant tubing. The compliant tubing is configured for a radioembolization particulate delivery of particulate through the compliant tubing. The strain gage pressure cuff is configured to detect a pressure change amount within the compliant tubing. When the pressure change amount is above a change amount threshold, the pressure change amount is indicative of a back-pressure and the strain gage pressure cuff is configured to communicate a notification to the radioembolization pressure system based on the pressure change amount being above the change amount threshold.
The present disclosure concerns simplified methods for preparing crystalline therapeutic agents encapsulated in phospholipid particles. The methods include simpler and more effective steps that provide for more efficient and consistent particle formation. The methods include reduced steps and more straightforward homogenization that yield a more consistent lipid encapsulated crystalline therapeutic.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
Delivery devices, as well as systems incorporating the same and methods of using the same are disclosed. A needle assembly includes a hub having first and second input ports and an auxiliary port, and an injection needle assembly. The injection needle assembly includes an elongate hollow stylet extending distally from the hub that includes an outer side wall defining an outer lumen fluidly coupled to the auxiliary port, a first inner side wall defining a middle lumen disposed within the outer lumen that is fluidly coupled to the first input port, a second inner side wall defining an inner lumen disposed within the middle lumen that is fluidly coupled to the second input port, and a mixing chamber fluidly coupled to the outer lumen, the middle lumen, and the inner lumen.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A drainage system includes a fluid-receiving container that includes an inlet and a drainage conduit communicatively coupled to the inlet of the fluid-receiving container. A first one-way valve is along the drainage conduit that provides a one-way fluid flow direction through the drainage conduit into the fluid-receiving volume. A displacement body is out-of-line with the drainage conduit and fluidly connected to the drainage conduit. The displacement body is configured to be actuated and released to provide a negative pressure to a fluid-receiving passageway through the drainage conduit. Actuation of the displacement body displaces air within the fluid-receiving passageway, the air being forced into the fluid-receiving volume by a second one-way valve and inhibited from escaping the fluid-receiving volume by the first one-way valve.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
Systems and methods of use of a radioembolization delivery device (RDD) for radiation therapy to cause tumor death may include one or more vial compartments containing a material loaded into a housing of the RDD. The RDD may include a plunger and one or more delivery lines coupled to the housing and a microcatheter. Upon activation in a dispelling direction, the plunger may dispel and deliver the material including a first material or a second material from the vial compartments, through the delivery lines, and to the microcatheter to a tumor. An active oxygen releasing component may be delivered as the first material prior, during, or after delivering an radioactive mixed particulate as the second material such that, upon exposure, the active oxygen releasing component interacts with radiation from the radioactive mixed particulate to lead to death of the tumor.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A vascular occlusion device includes a plurality of radially-extending segments and a plurality of angled bends connecting ends of two or more radially-extending segments of the plurality of radially-extending segments. Each angled bend may define a contact point configured to anchor to a vessel wall. The vascular occlusion device may be configurable between an unexpanded state and an expanded state, and when the vascular occlusion device is in the expanded state, the plurality of angled bends expand such that the contact points contact the vessel wall. The contact points may define a width of the vascular occlusion device in a direction perpendicular to a length of the vascular occlusion device. The width may be configured to correspond to a diameter of a blood vessel.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
73.
DELIVERY SYSTEMS, NEEDLE ASSEMBLIES AND METHODS OF DELIVERING COMPONENTS
A needle assembly includes an elongate cannula including an outer lumen defining a first channel and having a plurality of outer lumen ports, the plurality of outer lumen ports being arranged in a plurality of outer rings about the outer lumen in a circumferential direction, and each of the plurality of outer rings being spaced from one another in a longitudinal direction. The needle assembly further includes an inner cannula disposed within the outer lumen and including an inner lumen defining a second channel and having a plurality of inner lumen ports, the plurality of inner lumen ports being arranged in a plurality of inner rings about the inner lumen in the circumferential direction, and each of the plurality of inner rings being spaced from one another in the longitudinal direction. The plurality of outer rings and the plurality of inner rings are aligned in the longitudinal direction.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
74.
Biopsy System & Device Having a Chilled Biopsy Needle
A biopsy device having an elongate biopsy needle and a thermal cooling device. The biopsy device includes an elongate biopsy needle that has a proximal end portion, an intermediate portion, and a distal end portion. The elongate biopsy needle is made of a thermally conductive material. The biopsy device includes a thermally conductive mechanical member that extends between the proximal end portion of the elongate biopsy needle and the thermal cooling device. The thermally conductive mechanical member has a first end and a second end. The biopsy device includes a first thermo-mechanical coupler that connects the first end of the thermally conductive mechanical member to the thermal cooling device and a second thermo-mechanical coupler that connects the second end of the thermally conductive mechanical member to the proximal end portion of the elongate biopsy needle.
Embodiments disclosed herein are directed to an anti-ingrowth cathlock including a compliant gasket. The cathlock can engage an outer surface of a catheter and secure the catheter to a stem of a port, or similar vascular access device, The gasket can be compressed between the cathlock and one of the catheter, stem, or port body to form a continuous outer profile therebetween and mitigate tissue ingrowth. Due to the tolerances during manufacture of the catheter, cathlock and port, gaps can occur between these portions when assembled, allowing for tissue ingrowth and complicating explantation of the port/catheter/cathlock assembly. The compliant gasket can be disposed on one of the port or the catheter and can fill these gaps, mitigating tissue ingrowth.
Embodiments disclosed herein are directed to a dual, in-line port having a body defining a first reservoir and a second reservoir arranged along a central port axis. Dual, in-line ports can be advantageous since the port can be placed through an incision site, along the central port axis, requiring a smaller incision site than side-by-side dual ports. Further, the port can include a stem extending from a side surface of the body, between the first and second reservoirs, the stem can be angled such that an axis of the catheter can extend parallel to the central port axis. The angled, side stem can mitigate disparities in fluid paths and fluid resistance between the first and second reservoirs and the respective catheter lumen. Embodiments can include a pivotable stem configured to allow an axis of the stem to be repositioned relative to the central port axis.
The present disclosure concerns protective layers covering drug-coated layers on the external surface of a balloon that offer protection to the drug-coating until the balloon is in positions and ready for inflation. In aspects, the protective layer is water-soluble, meaning that the protective layer starts to dissolve within a subject's circulatory system once introduced. The protective layer is of a sufficient thickness or density over the drug-coating to allow for the balloon to be positioned in situ before exposing completely the drug-coating. The protective layer allows for preservation of therapeutic on the balloon surface, thereby increasing the accuracy of site-specific delivery.
A biopsy device includes a sample transport cannula, a sample collection basket, and a plug. The sample collection basket defines a basket volume. The sample collection basket is configured to receive a biopsied sample via the sample transport cannula. The plug is coupled to the sample collection basket. The plug includes a body, a marker and a septum. The body defines a plug lumen extending through a first end and a second end. The plug lumen is open to the basket volume during a sampling procedure. The marker is positioned within the plug lumen. The septum seal is positioned within the plug lumen proximal to the marker and is configured to maintain a vacuum pressure within the sample transport cannula during sample collection. During a marking procedure, the sample transport cannula is engaged to the plug such that the plug lumen is fluidically coupled to the sample transport cannula.
A61B 10/02 - Instruments for taking cell samples or for biopsy
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
79.
Multi-Function Adapter for Vascular Access Device Placement
Embodiments disclosed herein are directed to a multi-function adapter system for placing a distal tip of a catheter at a target location. The system is configured to maintain one or more electrical communication pathways with the catheter distal tip during a placement procedure. Two or more electrical pathways can be cross-referenced to determine accuracy. The electrical pathways can include a clip and first tether that provides a versatile electrical pathway in that the clip can be selectively coupled with either a saline column, stylet, guidewire, or needle. A flushing adapter can include a second tether formed integrally therewith and provide a second electrical pathway with a saline column. The stylet or guidewire can be fixedly coupled with the flushing adapter and can provide a second electrical pathway with the second tether. These electrical pathways can provide a fail-safe system to ensure electrical communication with the distal tip of the catheter.
Systems and methods to use an adaptor component for a particulate material delivery assembly to deliver a mixed particulate solution to a patient, the adaptor component including at least a pair of device connector ports. Each device connector port is configured to connect to a corresponding delivery line connector of a particulate delivery device to receive the mixed particulate solution. The adaptor component further includes a guidewire connector port configured to connect to a containment bag unit, the containment bag unit including a guidewire disposed therein and a catheter connector port configured to connect to a microcatheter to deliver the mixed particulate solution to the patient. The guidewire is configured to retract into and extend from the containment bag unit to position the microcatheter within the patient without disconnecting at least one of the pair of device connector ports from the delivery line connector of the particulate delivery device.
A lipid emulsion is provided herein, including sunflower lecithin, an oil, a co-surfactant, and a cryogenic agent. Also provided is a method of preparing a lipid emulsion, the method including: (i) dissolving sunflower lecithin in water to create an aqueous phase; (ii) mixing an oil, a co-surfactant and a cryogenic agent to create an organic phase; and (iii) homogenizing the aqueous and organic phases to produce the lipid emulsion, wherein the lipid emulsion has a mean particle size of less than about 1000 nm.
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
82.
BIOPSY MARKER UTILIZING LIGHT CURED BIOABSORBABLE GELS TO SUPPORT TISSUE
in situin situ within a cavity or space in a subject by light-initiated cross-linking as a precursor solution is applied into the desired space. In aspects, the precursor solution includes a tracking material and/or therapeutic or other component therein to provide a benefit to the subject as the gel degrades. Also contemplated are devices for application of the precursor solution that initiate cross-linking as the solutions fills the desired space.
A catheter device includes a body extending between a proximal portion and a distal portion and defining a lumen and at least one lateral opening in communication with the lumen at the distal portion. At least one vibrational pad is positioned within the lumen to adjustably protrude radially through the at least one lateral opening, such that the at least one vibrational pad is energized at a frequency and amplitude sufficient to break apart sub-intimal or medial plaque.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
Embodiments herein are directed to a measurement device. The measurement device includes a processing device, a catheter, and a tip portion. The tip portion is disposed at a distal end of the catheter. The tip portion receives the distal end of the catheter. A diaphragm film assembly is coupled to the tip portion at an opposite end that receives the distal end of the catheter. The diaphragm film assembly is configured to flexibly move between a plurality of positions based on an applied pressure that displaces the diaphragm film assembly. A sensor assembly communicatively coupled to the processing device, the sensor assembly is configured to measure the applied pressure displacing the diaphragm film assembly and the processing device determines a concentration of ammonia currently in a fluid at the tip portion.
The present disclosure relates to protective layers over a drug-coating layer that restrict the expansion of the balloon. The protective layer is arranged so that parts of the balloon can expand through the protective layer and expose the coating layer and allow for transfer of the coating layer at the point of expansion. The protective layer has a higher modulus of elasticity that causes the balloon to expand through gaps therein.
The present disclosure concerns drug coating layers for medical devices that cover an exterior surface or portion thereof. The drug coating layers include a bioabsorbable material with a therapeutic or a polymer microparticle loaded with a therapeutic embedded therein. As the material is bioabsorbed the therapeutic is released and available to provide localized activity in a subject. In some aspects, the drug coating layer is of a material that due to the body temperature of the subject becomes tacky and allows for adhesion to the vessel wall.
The present disclosure is generally directed to novel bead geometries that can provide improved sanding efficiencies in rotational atherectomy procedures. The abrasive elements disclosed herein may open stenotic lesions to diameters that are substantially larger than the maximum diameter of the abrasive element. In some embodiments, the abrasive elements may open stenotic lesions to diameters that are substantially larger than the maximum diameter of the sheath from which the abrasive element is delivered through. In some embodiments the abrasive elements are configured to expand when the abrasive elements are rotated at high speeds. In some embodiments, the abrasive elements have local centers of mass that are positioned at opposite diagonal ends. Accordingly, the abrasive elements disclosed herein may have improved sanding ranges, reduce treatment times, and prevent re-stenosis.
A biopsy device includes a sample notch cannula having a proximal end and a distal end, and sample notch that receives tissue from a target site. A cutting cannula is located within the sample notch cannula, and is retractable between an open position and a closed position. An outer cannula having a first end and a second end is coaxially positioned about the sample notch cannula and is retractable between a sealed position and a venting position. A vacuum assembly is fluidly coupled to the first end of the outer cannula and the proximal end of the sample notch cannula, and provides a vacuum to the sample notch cannula and the outer cannula. The outer cannula applies vacuum to a surface of the target site to seal the sample notch cannula from atmosphere in the sealed position.
An apparatus is for forming a balloon layer, such as on an expanded base balloon. The apparatus includes a mandrel supporting the expanded base balloon. At least one gripper is provided for gripping the balloon layer, and an actuator is for stretching the balloon layer over the expanded base balloon, such as by moving the at least one gripper. Related methods for forming a balloon layer are also disclosed.
A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereonDental implantsImplanting tools
B05D 3/10 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by other chemical means
90.
Ultrasonic Hypotube Devices for Treatment of CTOs and Stenotic Lesions
A catheter assembly includes an outer sheath and a hypotube ultrasonic transmission member. The outer sheath has a first end, a second end, a frustoconical side wall portion located proximal to the second end, and a sheath lumen extending from the first end to the second end. The hypotube ultrasonic transmission member is disposed in the sheath lumen. The hypotube ultrasonic transmission member has a hypotube side wall, a proximal hypotube portion, a distal hypotube portion, and a tapered intermediate portion. The proximal hypotube portion is configured to be operatively coupled to an ultrasonic transducer. The proximal hypotube portion has a first diameter, and the distal hypotube portion has a second diameter that is less than the first diameter. The tapered intermediate portion is configured to transition from the first diameter to the second diameter. The tapered intermediate portion is located proximate the frustoconical side wall portion.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
A catheter includes a catheter body and a tip positioned at a distal end of the catheter body. The catheter further includes a first guidewire lumen extending through the catheter body and the tip, where a central axis of a distal opening of the first guidewire lumen is parallel to a longitudinal center line of the catheter. The catheter further includes a second guidewire lumen extending through the catheter body and the tip, where a central axis of a distal opening of the second guidewire lumen is perpendicular to the longitudinal center line of the catheter, and the distal opening of the second guidewire lumen defines an active side of the catheter. The catheter further includes a first magnet positioned along the tip.
An aspiration accessory includes a syringe barrel having a first end having a first end surface and a second end. The aspiration accessory further includes a plunger slidably engaged within the syringe barrel between an initial position and a suction position. The plunger includes a first end and a second end, and a plurality of flanges are positioned between the first end and the second end. The plurality of flanges are biased radially outward and the syringe barrel compresses the plurality of flanges in the initial position. When the plunger is moved to the suction position, a biasing force on the plurality of flanges causes the plurality of flanges to flex radially outward and engage the first end surface of the syringe barrel, such that the plunger locks in the suction position.
A61B 10/02 - Instruments for taking cell samples or for biopsy
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
93.
CATHETER ASSEMBLIES AND METHODS OF PERFORMING ELECTROPORATION
A catheter assembly includes an inner catheter assembly and an outer catheter disposed about the inner catheter assembly and being retractable between an extended position and a retracted position. A plurality of self-expanding spokes are affixed to the inner catheter assembly, and a plurality of electrode disks are mounted on the plurality of self-expanding spokes. The plurality of self-expanding spokes have a low-profile position between the outer catheter and the inner catheter assembly when the outer catheter is in the extended position, and the plurality of self-expanding spokes move to an expanded position when the outer catheter is in the retracted position.
in situin situ. The hydrophobic nature of the drug combined with the mechanism of action allow for site specific treatment to wear away plaque within the vessel walls. The site specific delivery offers the potential for lower dosing and the choice of trodusquemine provides a further alternative to conventional medications.
Embodiments disclosed herein are directed to a clamshell carhlock device and methods thereof. The cathlock includes a first portion hingedly coupled to a second portion and rotatable through a plane extending perpendicular to a central longitudinal axis. A user can apply opposing, radially inward, “pinching” force to transition the cathlock to the closed position, mitigating applying any pressure directly to the patient. The cathlock further includes a compliant sleeve coupled to an inner surface thereof and configured to slidably engage the cathlock with the catheter in both the open and closed positions. The sleeve can engage the catheter in an interference fit to allow a user to position the cathlock along the catheter and for the cathlock to remain in place until repositioned.
An apparatus for managing pleural or peritoneal fluid of a patient, the apparatus includes a valve and an elongated tubular portion extending from the valve with a lumen therein extending from a proximal end of the tubular portion to a distal end of the tubular portion. The elongated tubular portion further comprises an internal portion, the internal portion configured to be inserted into the pleural or peritoneal space of the patient for removing fluid from a pleural or peritoneal space. The elongated tubular portion further comprises an external portion that is closer to the proximal end than the internal portion, the external portion configured to remain external to the patient for draining the fluid via the internal portion, wherein the external portion has a shape memory feature with a non-linear natural state.
A system for managing or containing a portion of a catheter that exits a patient's body. The system may include a first catheter management portion comprising a first surface configured to contact a patient's skin, a second surface opposite the first surface, the second surface configured to face away from a patient's skin when the first surface contacts the patient's skin and a catheter pass-through portion configured to have a proximal end of the catheters passed therethrough to isolate a portion of the proximal end of the catheter from a patient's skin. The system may include one or more cover portions or a pouch configuration configured to cover the catheter when the catheter is not being used for a drainage procedure.
A device may include an elongated catheter passage portion configured to have a distal end in a pleural or peritoneal cavity with a proximal end outside of the pleural or peritoneal cavity. A device may include a port apparatus at a proximal end of the elongated catheter, wherein the port has a connector interface for connection of a drainage device thereto and is configured to provide fluid communication with the catheter via a valve.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A medical device for closing a vessel. The medical device comprises a catheter shaft defining a longitudinal axis, and an expansion element positioned at or near a distal end of the catheter shaft. The expansion element has a radially contracted configuration and a radially expanded configuration. The expansion element is configured to flatten the vessel in the radially expanded configuration. The medical device further comprises one or more injection ports for injecting an adhesive into the vessel.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A biopsy device includes an outer cannula having a body with a distal end, a proximal end, and at least one wall defining a passageway through the body, the distal end being open and having a sharpened edge. A first electrode and a second electrode are proximal the distal end of the body, and an inner needle is housed within the passageway defined by the outer cannula. The inner needle includes a piercing tip and is retractable from an extended configuration into the passageway to expose the sharpened edge of the outer cannula and allow the sharpened edge to cut a tissue core that is received by the passageway. An electrical pathway is formed between the first electrode and the second electrode when a voltage is applied between the first and second electrode to sever the tissue core.
