The invention relates to the radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject. In particular the invention relates to an endorectal probe device for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject. Furthermore the invention relates to an afterloading apparatus for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject using an endorectal probe device according to the invention. Moreover the invention relates to a method for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject, wherein the method implements the endorectal probe device according to the invention.
Device for supporting the testing of a brachytherapy applicator and a method for testing of such a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments
The invention relates to a device for supporting the testing of a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments.
The invention also relates to a method for testing of a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments.
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Education; Teaching; Providing of training and courses; Publishing and editing of books, newspapers, magazines and other printed media relating to health care and to medical and social care services; Rental of motion pictures; Organisation of performances; Lending and distributing of books and periodicals; Arranging of exhibitions for cultural or educational purposes; Arranging and giving cultural and educational lectures; Publishing, including electronic or telecommunications networks, also relating to health care and medical and social care services; Providing information relating to education or training; Teaching; publication of reference books; Education and instruction in the transfer of knowledge, skills, or abilities. Scientific and technological services and research and design relating thereto; Pharmaceutical and scientific research; Scientific research relating to medical treatment; Scientific studies and laboratory research in the medical field; Epidemiological laboratory studies; Services of chemists and physicists; Services provided by medical, bacteriological and chemical laboratories; Scientific research for the pharmaceutical and medical industry; Medical research; Consultancy, information and awareness-raising regarding the aforesaid services, including provided via electronic networks such as the Internet. Medical services; Hospital services; Nursing and other paramedical services; Medical care; Doctors' services; Medical examinations; Rehabilitation; Drawing up of medical expert reports; Medical services; Medical assistance, Including radiation therapy; Psychological or medical therapy; Consultancy, assistance, advice and therapy in the field of health and medical care; Nutrition information (dietetics); Services of psychiatrists, psychologists, midwives, gynaecologists and paediatricians; Services of vaccination clinics; Hygiene and beauty care services for people staying in hospitals; Pharmaceutical advice; Providing information, in particular on diseases, health care, rehabilitation, medical care, home care, maternity care, nursing and home nursing; Consultancy for people relating to issues regarding health and illness; Consultations with care providers in the medical and nursing fields to ensure the necessary care in the aforesaid fields; Medical examination of individuals; Drawing up of expert reports by doctors; Consultancy and information regarding the aforesaid services, including provided via electronic networks such as the Internet.
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Education; Teaching; Providing of training and courses; Publishing and editing of books, newspapers, magazines and other printed media relating to health care and to medical and social care services; Rental of motion pictures; Organisation of performances; Lending and distributing of books and periodicals; Arranging of exhibitions for cultural or educational purposes; Arranging and giving cultural and educational lectures; Publishing, including electronic or telecommunications networks, also relating to health care and medical and social care services; Providing information relating to education or training; Teaching; publication of reference books; Education and instruction in the transfer of knowledge, skills, or abilities. Scientific and technological services and research and design relating thereto; Pharmaceutical and scientific research; Scientific research relating to medical treatment; Scientific studies and laboratory research in the medical field; Epidemiological laboratory studies; Services of chemists and physicists; Services provided by medical, bacteriological and chemical laboratories; Scientific research for the pharmaceutical and medical industry; Medical research; Consultancy, information and awareness-raising regarding the aforesaid services, including provided via electronic networks such as the Internet. Medical services; Hospital services; Nursing and other paramedical services; Medical care; Doctors' services; Medical examinations; Rehabilitation; Drawing up of medical expert reports; Medical services; Medical assistance, Including radiation therapy; Psychological or medical therapy; Consultancy, assistance, advice and therapy in the field of health and medical care; Nutrition information (dietetics); Services of psychiatrists, psychologists, midwives, gynaecologists and paediatricians; Services of vaccination clinics; Hygiene and beauty care services for people staying in hospitals; Pharmaceutical advice; Providing information, particularly on diseases, health care, rehabilitation, medical care, home care, maternity care, nursing and home nursing; Consultancy for people relating to issues regarding health and illness; Consultations with care providers in the medical and nursing fields to ensure the necessary care in the aforesaid fields; Medical examination of individuals; Drawing up of expert reports by doctors; Consultancy and information regarding the aforesaid services, including provided via electronic networks such as the Internet.
5.
A DEVICE FOR SUPPORTING THE TESTING OF A BRACHYTHERAPY APPLICATOR AND A METHOD FOR TESTING OF SUCH A BRACHYTHERAPY APPLICATOR PRIOR TO THE USE OF THE BRACHYTHERAPY APPLICATOR IN BRACHYTHERAPY RADIATION TREATMENTS
The invention relates to a device for supporting the testing of a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments. The invention also relates to a method for testing of a brachytherapy applicator prior to the use of the brachytherapy applicator in brachytherapy radiation treatments.
The invention relates to the radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject. In particular the invention relates to an endorectal probe device for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject. Furthermore the invention relates to an afterloading apparatus for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject using an endorectal probe device according to the invention. Moreover the invention relates to a method for effecting radiation treatment of colorectal cancerous tissue in the rectum of a human or animal subject, wherein the method implements the endorectal probe device according to the invention.
An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the radiological image and extracting quantitative features that describe the ROI or the VOI. The method also includes creating a radiological image record including the quantitative features, imaging parameters of the radiological image and clinical parameters and storing the radiological image record in a data structure containing a plurality of radiological image records. In addition, the method includes receiving a request with the patient's radiological image or information related thereto, analyzing the data structure to determine a statistical relationship between the request and the radiological image records and generating a patient report with a diagnosis, a prognosis or a recommended treatment regimen for the patient's disease based on a result of analyzing the data structure.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
8.
Image analysis method supporting illness development prediction for a neoplasm in a human or animal body
The present invention relates to an image analysis method for providing information for supporting illness development prediction regarding a neoplasm in a human or animal body. The method includes receiving for the neoplasm first and second image data at a first and second moment in time, and deriving for a plurality of image features a first and a second image feature parameter value from the first and second image data. These feature parameter values being a quantitative representation of a respective image feature. Further, calculating an image feature difference value by calculating a difference between the first and second image feature parameter value, and based on a prediction model deriving a predictive value associated with the neoplasm for supporting treatment thereof. The prediction model includes a plurality of multiplier values associated with image features. For calculating the predictive value the method includes multiplying each image feature difference value with its associated multiplier value and combining the multiplied image feature difference values.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the radiological image and extracting quantitative features that describe the ROI or the VOI. The method also includes creating a radiological image record including the quantitative features, imaging parameters of the radiological image and clinical parameters and storing the radiological image record in a data structure containing a plurality of radiological image records. In addition, the method includes receiving a request with the patient's radiological image or information related thereto, analyzing the data structure to determine a statistical relationship between the request and the radiological image records and generating a patient report with a diagnosis, a prognosis or a recommended treatment regimen for the patient's disease based on a result of analyzing the data structure.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
10.
SULFONAMIDE, SULFAMATE AND SULFAMIDE DERIVATIVES OF ANTI-CANCER AGENTS
The present invention is directed to compounds having formula (I): A-L-R1, wherein A is an anticancer agent comprising at least one group selected from the group comprising OH, NH and NH2 and L is a direct bond or L is a linker and R1 is a sulfonamide, sulfamate or sulfamide group. L is substituted on O of OH or on N of NH or NH2 of A or wherein L replaces OH of A, or O-L replaces a C(=O)-OH group of A and wherein in the case L is a direct bond R1 is substituted on O of OH or on N of NH or NH2 of A or wherein R1 replaces OH of A, or O-R1 replaces a C(=O)-OH group of A. The invention is also directed to a treatment of cancer with the compounds.
C07D 241/10 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
A61K 31/4168 - 1,3-Diazoles having a nitrogen atom attached in position 2, e.g. clonidine
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
A61K 31/4738 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems
11.
IMAGE ANALYSIS METHOD SUPPORTING ILLNESS DEVELOPMENT PREDICTION FOR A NEOPLASM IN A HUMAN OR ANIMAL BODY
The present invention relates to an image analysis method for providing information for supporting illness development prediction regarding a neoplasm in a human or animal body. The method includes receiving for the neoplasm first and second image data at a first and second moment in time, and deriving for a plurality of image features a first and a second image feature parameter value from the first and second image data. These feature parameter values being a quantitative representation of a respective image feature. Further, calculating an image feature difference value by calculating a difference between the first and second image feature parameter value, and based on a prediction model deriving a predictive value associated with the neoplasm for supporting treatment thereof. The prediction model includes a plurality of multiplier values associated with image features. For calculating the predictive value the method includes multiplying each image feature difference value with its associated multiplier value and combining the multiplied image feature difference values.
The present invention relates to a decision support system and an image analysis method for providing information for enabling determination of a phenotype of a neoplasm in a human or animal body for enabling prognostication, comprising the steps of: receiving, by a processing unit, image data of the neoplasm; and deriving, by the processing unit, a plurality of image feature parameter values from the image data, said image parameter values relating to image features associated with the neoplasm; and deriving, by said processing unit using a signature model, one or more neoplasm signature model values associated with the neoplasm from said image feature parameter values, wherein said signature model includes a functional relation between or characteristic values of said image feature parameter values for deriving said neoplasm signature model values.
The present invention is directed to novel carbonic anhydrase IX inhibitors comprising a nitroimidazole moiety substituted with a heterocycle or phosphinate and having sulfonamide, sulfamate or sulfamide groups. The present invention is also related to the use of these novel carbonic anhydrase IX inhibitors in cancer treatment, especially radiotherapy and chemotherapy and the use in treatment of infections.
C07D 233/95 - Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the radiological image and extracting quantitative features that describe the ROI or the VOI. The method also includes creating a radiological image record including the quantitative features, imaging parameters of the radiological image and clinical parameters and storing the radiological image record in a data structure containing a plurality of radiological image records. In addition, the method includes receiving a request with the patient's radiological image or information related thereto, analyzing the data structure to determine a statistical relationship between the request and the radiological image records and generating a patient report with a diagnosis, a prognosis or a recommended treatment regimen for the patient's disease based on a result of analyzing the data structure.
The invention is in the art of medical treatments, in particular the treatment of tumors with ionizing radiation. It provides means and methods for predicting whether a subject is likely to develop radiation damage upon radiotherapy. The invention provides tools that allow individualized and optimized radiation treatment of a subject in need of a radiation treatment. The invention also provides methods of determining the risk of developing severe dyspnea after radiation treatment. More in particular, the invention relates to an in vitro method for predicting the risk of developing radiation induced toxicity comprising the steps of obtaining mitochondrial DNA from a sample of a subject, determining the number of non-synonymous variations present in at least one gene encoding a mitochondrial protein, attributing a value to the number of non- synonymous variations, wherein a higher value corresponds to a higher risk of developing radiation induced lung toxicity.
The present invention relates to a decision support system and an image analysis method for providing information for enabling determination of a phenotype of a neoplasm in a human or animal body for enabling prognostication, comprising the steps of: receiving, by a processing unit, image data of the neoplasm; and deriving, by the processing unit, a plurality of image feature parameter values from the image data, said image parameter values relating to image features associated with the neoplasm; and deriving, by said processing unit using a signature model, one or more neoplasm signature model values associated with the neoplasm from said image feature parameter values, wherein said signature model includes a functional relation between or characteristic values of said image feature parameter values for deriving said neoplasm signature model values
CNRS Centre National de la Recherche Scientifique (France)
Inventor
Lambin, Philippe
Winum, Jean-Yves
Supuran, Claudiu
Abstract
The present invention concerns novel carbonic anhydrase IX inhibitors comprising a nitroimidazole moiety and their use in therapy of hypoxic conditions, in particular cancer treatment, especially chemotherapy and radiotherapy. The compounds of the invention have an increased specificity for the carbonic anhydrase IX enzyme compared to the art. The present invention relates to novel nitroimidazole derivates represented by formula (1).
