The present application relates to the field of remote sensing image data processing, and in particular to a method for determining a seam line of orthoimages, a method for generating a mosaic image of orthoimages, and a device and a medium. The method for determining a seam line of orthoimages comprises: using a crawling search method to respectively extract valid area contours of a master image and a slave image; calculating difference values of valid pixels within an overlapping area between the master image and the slave image by means of a difference function, so as to obtain a difference map of a valid area, and if the number of intersection points is greater than 2, calculating the position of a centroid of the overlapping area on the basis of the coordinates of each contour point of an intersection contour, then determining an internal local window centered on the centroid in the difference map, searching the internal local window, and using a position with the minimum difference value as an optimization end point and the intersection points as optimization start points; and using an A star algorithm to determine a seam line on the basis of the optimization start points and the optimization end point. The present application can more accurately determine a seam line of a plurality of orthorectified remote sensing images with irregular contours.
The present invention relates to the field of communication and sensing, and specifically to a communication and sensing integrated device based on a seven-core optical fiber interferometer and an application method therefor. The application method comprises: a first beam splitter splitting, into reference light and signal light, a light source emitted by a narrow linewidth laser; performing modulation by means of a first coherent optical transmitter and a second coherent optical transmitter; amplifying the light by means of a first amplifier and a second amplifier, and then enabling the light to pass through a multi-core optical fiber from a fan-in end, and to output from a fan-out end; performing beam splitting by means of a second beam splitter and a third beam splitter, and performing demodulation by means of a first coherent receiver and a second coherent receiver; and finally, a phase-locked loop performing interference elimination on preliminarily-demodulated reference light and preliminarily-demodulated signal light to obtain finally-demodulated reference light and finally-demodulated signal light. The present invention uses a phase-locked loop to further eliminate disturbance noise of reference light and signal light. Therefore, noise interference is eliminated in continuous low-frequency detection, thereby improving the communication and sensing effect.
The present invention pertains to the technical field of medicine. Specifically disclosed are a dolastatin analogue, a ligand-drug conjugate thereof, a preparation method therefor, and use thereof. According to the present invention, a toxin, a linker, and a linker moiety are separately optimized, and the compound is prepared by means of organic synthesis. Also disclosed is use of the compound and the ligand-drug conjugate thereof in preparing a medicament for preventing and treating diseases, the diseases including but not limited to hyperproliferative diseases and angiogenic diseases, such as cancer, chronic metabolic diseases, and cardiovascular diseases. Further disclosed is a drug/pharmaceutical composition. The ligand-drug conjugate of the present invention offers the following effects: high stability, reduced off-target-induced toxicity, an expanded therapeutic window, a good tumor tissue-targeting property, and an excellent in vivo anti-tumor effect, achieving reduced toxicity and enhanced efficacy. The present invention provides a research foundation for preparing ligand-drug conjugates with high efficacy and low toxicity, having broad application prospects.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A cable-type piezoelectric sensor and a manufacturing process therefor. The cable-type piezoelectric sensor comprises an electrode material layer, a piezoelectric material layer, and a shielding layer (300). The electrode material layer is columnar, the piezoelectric material layer comprises an emitter layer (210), a base layer (220), and a collector layer (230) arranged sequentially, the emitter layer (210) is arranged on the outer surface of the electrode material layer, and the shielding layer (300) is arranged on the side of the collector layer (230) distant from the base layer (220). By means of the emitter layer (210), the base layer (220), and the collector layer (230) in the piezoelectric material layer, the cable-type piezoelectric sensor possesses a device structure of a bipolar junction transistor, thereby achieving amplification of current and voltage, enhancing the sensitivity of the device, and making the device suitable for more application scenarios. Due to integration in a cable form, the cable-type sensor possesses significant advantages over other sensors in terms of electromagnetic shielding, robustness, and waterproof performance, integrates functions such as sensing, amplification, and transmission, and is suitable for broader application scenarios.
Disclosed in the present invention are an ultra-small high-performance near-infrared long-afterglow nanoparticle, and a preparation method therefor and a use thereof. The preparation method comprises the following steps: S1, adding gallium acetylacetonate, zinc acetylacetonate, chromium acetylacetonate, and a long-chain alkyl diol to a mixed solution containing oleic acid, oleylamine, and octadecene, and carrying out stirring, vacuumizing and heating to 50-110°C, wherein the long-chain alkyl diol contains 10-18 carbon atoms; S2, heating to 160-240°C under nitrogen protection and maintaining the temperature; and S3, continuing heating to 260-340°C, maintaining the temperature, and carrying out post-treatment to obtain the ultra-small high-performance near-infrared long-afterglow nanoparticle. The ultra-small high-performance near-infrared long-afterglow nanoparticle prepared by the present invention has an average diameter of less than 5 nm and an excellent long-afterglow luminescence duration, and has wide prospects for application in the fields of optical imaging and the development of biomedical diagnostic reagents.
A method for preparing a mid-infrared focal plane detector on the basis of Sn-doped PbSe quantum dots. The preparation of a mid-infrared focal plane detector involves: on an ROIC substrate, respectively using an ion beam sputtering method, a spin coating method, the spin coating method and the ion beam sputtering method to sequentially construct an Au bottom electrode, a PbS hole transport layer, an Sn-doped PbSe photosensitive layer and a PIN heterojunction of a ZnO electron transport layer; and finally, using the ion beam sputtering method to deposit an ITO top electrode. The method based on Sn-doped PbSe quantum dots has the advantage of high mid-infrared response; and the method can realize the preparation of low-cost, chip-scale and simple-process uncooled PbSe mid-infrared focal plane detectors.
H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
H01L 31/032 - Inorganic materials including, apart from doping materials or other impurities, only compounds not provided for in groups
H01L 31/105 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier being of the PIN type
H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
7.
METHOD AND SYSTEM FOR PROVIDING VIRTUAL NETWORK TOPOLOGY CONFIGURATION SERVICES BASED ON MAML AND TRANSFER LEARNING, AND STORAGE MEDIUM
The present invention relates to the technical field of optical communications, and discloses a method and system for providing virtual network topology configuration services based on MAML and transfer learning, and a storage medium. The method includes: building a network architecture using a software-defined network; receiving, by the network architecture, configuration information to configure a virtual network topology; and calling, by the network architecture, an intelligent machine learning service providing module to execute an MAML algorithm and a transfer learning algorithm to provider a user with machine learning services, the machine learning services including quality of transmission estimation, fault management, and resource allocation. By means of the present invention, the quality of service and efficiency of network virtualization can be improved.
H04L 41/0895 - Configuration of virtualised networks or elements, e.g. virtualised network function or OpenFlow elements
H04L 41/122 - Discovery or management of network topologies of virtualised topologies e.g. software-defined networks [SDN] or network function virtualisation [NFV]
H04L 41/16 - Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks using machine learning or artificial intelligence
8.
DUAL-VIEW DIGITAL BREAST TOMOSYNTHESIS-BASED ARCHITECTURAL DISTORTION DETECTION METHOD AND SYSTEM
The present invention relates to the technical field of image analysis, and provides a dual-view digital breast tomosynthesis-based architectural distortion detection method and system. The method comprises the following steps: collecting three-dimensional breast tomosynthesis images of two projection position views and processing same into two-dimensional tomographic slices; using bounding boxes to label positions of architectural distortions in the two-dimensional tomographic slices; pairing the labeled two-dimensional tomographic slices of the two projection position views of the same breast; using a computer-aided detection model to predict two-dimensional detection boxes corresponding to the positions of the architectural distortions in the paired two-dimensional tomographic slices and to extract from the two-dimensional detection boxes representation vectors of breast tissue structures; using the representation vectors of the breast tissue structures of the paired two-dimensional tomographic slices to match the two-dimensional detection boxes in the tomographic slices of the two projection position views; fusing the two-dimensional detection boxes into three-dimensional detection boxes; and, on the basis of single-view and dual-view information, removing some of the three-dimensional detection boxes to obtain finally kept three-dimensional detection boxes.
A flexible wristband system for monitoring hemodynamics and recognizing gestures, relating to the technical field of medical health monitoring and chalcogenide integrated photonics, and comprising: a wristband apparatus (3), an electric pulse generating apparatus (1), a signal light generating apparatus (2), a control device (4), and an information receiving, processing and display device (5), wherein a signal output end of the electric pulse generating apparatus (1) is electrically connected to a signal input end of the wristband apparatus (3), a signal output end of the signal light generating apparatus (2) is connected to the signal input end of the wristband apparatus (3) by means of an optical fiber, and signal input ends of the electric pulse generating apparatus (1), of the signal light generating apparatus (2) and of the information receiving, processing and display device (5) are all connected to a signal output end of the control device (4). The flexible wristband system can improve detection sensitivity and the capability of detecting weak signals.
Provided are a wearable heart ultrasound imaging patch system and an imaging method. The wearable heart ultrasound imaging patch system comprises: a control device (1), an electrical pulse generation apparatus (2), a multi-channel pulse amplification control apparatus (3), an ultrasound imaging patch system (4), a target to be imaged (5), a signal light generation apparatus (6), a signal conversion and acquisition apparatus (7), and a data processing and display apparatus (8). An electrical pulse is generated by the electrical pulse generation apparatus (2) and input into the ultrasonic imaging patch system (4) via the multi-channel pulse amplification control apparatus (3). Laser light is output by the signal light generation apparatus (6) and converted, via the signal conversion and acquisition apparatus (7), into an optical pulse signal, which is then input into the heart ultrasound imaging patch system (4). An ultrasound image of the target to be imaged (5) is acquired by the ultrasound imaging patch system (4) and transmitted to the signal conversion and acquisition apparatus (7) via an optical fiber, and the signal conversion and acquisition apparatus (7) converts an optical signal of the ultrasound image into an electrical signal and then inputs the electrical signal into the data processing and display apparatus (8). Compared with the conventional technology, the present disclosure has the phased array imaging technology incorporated and achieves acoustic detection with a large angle of view and ultra-high sensitivity.
A gain medium for a low-differential-mode-gain few-mode optical amplifier, a preparation method therefor and the application thereof, and a low-differential-mode-gain few-mode optical amplifier comprising same. The gain medium sequentially comprises, from bottom to top, a silicon substrate (1), a silicon oxide layer (2), a passive transmission waveguide layer (3), rare-earth-doped gain layers (4-7) and an upper waveguide cladding layer (8), wherein the rare-earth doping concentrations in the rare-earth-doped gain layers (4-7) gradually increase from bottom to top. The present invention can improve the mode gain; and by means of regulating a matching mode between a doping concentration and a light field distribution, the effect of reducing the gain difference between modes is also achieved.
G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
G02B 6/13 - Integrated optical circuits characterised by the manufacturing method
12.
PREPARATION METHOD AND USE OF DIAGNOSIS-TREATMENT INTEGRATED ANTIBODY-DRUG CONJUGATE FOR AUTOIMMUNE DISEASES
Disclosed are a preparation method and use of a diagnosis-treatment integrated antibody-drug conjugate for autoimmune diseases. The preparation method comprises the following steps: mixing a contrast agent with an antibody and performing coupling via a physical reaction or a chemical reaction to give a contrast agent-antibody conjugate; and then mixing a drug with the contrast agent-antibody conjugate and performing coupling via a physical reaction or a chemical reaction to finally give the antibody-drug conjugate. The prepared antibody-drug conjugate has near-infrared fluorescence imaging and CT imaging characteristics, can target an inflammatory lesion, and can be used for diagnosing or assisting the diagnosis of autoimmune diseases. Meanwhile, the antibody-drug conjugate has a good anti-inflammatory effect and can ameliorate symptoms such as pain and improve urination functions after treatment. It achieves treatment effects by adjusting the diversity and abundance of the topical microbiota, thereby treating autoimmune diseases.
A61P 13/10 - Drugs for disorders of the urinary system of the bladder
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
13.
MULTI-PRIMARY-COLOR FIELD-SEQUENTIAL-COLOR DISPLAY APPARATUS BASED ON QUANTUM DOTS
A multi-primary-color field-sequential-color display apparatus based on quantum dots. The apparatus comprises a liquid crystal module and a backlight module, wherein the backlight module is arranged directly behind the liquid crystal module, and comprises a plurality of light-emitting units and dimming structures each corresponding to a light-emitting unit, each dimming structure comprising a collimation structure corresponding to each light-emitting device in the corresponding light-emitting unit. A collimation structure is arranged for each light-emitting device in each light-emitting unit, such that each light-emitting unit in a backlight module can be fully collimated, thereby improving the light emission uniformity. The full width at half maximum of the spectrum of each light-emitting device in the backlight module is within a first preset range, such that the color purity of display can be improved as much as possible while ensuring that metamerism occurs effectively, thereby improving a display color gamut. Moreover, the number of primary colors of each light-emitting unit in the backlight module is not less than 4; and in combination with a corresponding dimming structure, the display color gamut can be further improved without affecting the light emission uniformity, thereby achieving a better display effect.
The present application provides a mutant protein of activation-induced cytidine deaminase, wherein the mutant protein has the following mutations when compared to hsAID: T82I, K10E, K34E, E156G, 181*, S38C, H130R, V152A, R174G, and T110A. The present application also provides a high-efficiency base editor, including the mutant protein of activation-induced cytidine deaminase of the present application and a DNA-specific binding protein, which are linked sequentially via a linking sequence. The present application also provides a targeted single-base editing system, including a targeted single-base editing protein and a target hyper mutation fragment. Compared with the existing single-base editing system based on activation-induced cytidine deaminase (AID), the system for inducing the mutant protein of the present application has a smaller molecular weight and higher mutation efficiency.
Provided is a use of an IFP35 family protein in diagnosis of sepsis or related diseases thereof. Provided is an IFP35 family protein as a marker for diagnosis, screening, severity assessment, monitoring, efficacy assessment, or prognosis assessment of sepsis or related diseases thereof, and non-sepsis infectious diseases. By measuring the content, the expression level and/or activity of the IFP35 family protein, diagnosis, screening, severity assessment, monitoring, efficacy assessment, or prognosis assessment of sepsis or related diseases thereof, and non-sepsis infectious diseases can be realized.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A01K 67/027 - New or modified breeds of vertebrates
16.
LASER BEAM MACHINING METHOD TARGETED AT CHALCOGENIDE MATERIALS AND INTEGRATED PHOTONIC DEVICE
Embodiments of this application provide a laser beam machining method targeted at chalcogenide materials and an integrated photonic device, relating to the technical fields of integrated photonic chip machining. The laser beam machining method targeted at chalcogenide materials includes: acquiring a dielectric substrate with a preset size, and cleaning the dielectric substrate; preparing a uniform and dense sulfide film on a surface of the dielectric substrate; obtaining a laser spot with a preset energy distribution pattern according to a preset machining pattern; generating laser spot scanning parameters according to the preset machining pattern; and carrying out etching-free laser oxidation machining on the sulfide film through the laser spot according to the spot scanning parameters to obtain a chalcogenide integrated photonic device. The laser beam machining method targeted at chalcogenide materials can significantly simplify the machining flow of integrated photonic chips and improve the machining efficiency of photonic chips.
The present invention discloses a concrete test device and method based on a load-corrosion coupling action, relating to the technical field of corrosion experimental devices for concrete sewage pipelines. The device simulates a real environment of a sewage pipeline based on the load-corrosion coupling action, applies mechanical load and chemical corrosion effects to a concrete specimen simultaneously, and accelerates a corrosion effect on the concrete specimen by exposing the concrete specimen. According to the device, researches on mechanical properties of a concrete material under the load-corrosion coupling action are realized, and an assessment sample basis is provided for researches on aging characteristics of the concrete sewage pipelines. The present invention further discloses a concrete test method based on the aforementioned test device.
G01N 3/16 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces applied through gearing
G01N 17/00 - Investigating resistance of materials to the weather, to corrosion or to light
18.
INVERSION TYPE LINER REHABILITATION APPARATUS AND METHOD FOR PIPE REHABILITATION AND REINFORCEMENT
Disclosed are an inversion type liner rehabilitation apparatus and method for pipe rehabilitation and reinforcement. The inversion type liner rehabilitation apparatus comprises a work vehicle, a power supply unit, a matrix mixing device, a hose impregnation and flattening device, a hose inversion device, and a mobile support frame. The work vehicle comprises a van body and a vehicle-mounted support frame located at the rear of the work vehicle; the van body provides a first accommodating space; and the first accommodating space is provided with a dry hose material storage area, a matrix material storage area, and a guide tube storage area. The power supply unit, the matrix mixing device, and the hose impregnation and flattening device are all located in the first accommodating space. The hose inversion device includes an inversion machine and an air pump. The mobile support frame comprises a support frame body and wheels arranged at the bottom of the support frame body. The top of the vehicle-mounted support frame is provided with a first mounting base used for being detachably connected to the inversion machine, and the top of the support frame body is provided with a second mounting base used for being detachably connected to the inversion machine. The present invention can effectively improve the construction efficiency of pipe rehabilitation and reinforcement.
A control method and a control system of a lithium niobate based Mach-Zehnder interferometer modulator are disclosed. The system includes a laser, a Mach-Zehnder interferometer, a photoelectric detection module and an analog circuit bias control module. The method includes: converting, by the photoelectric detection module, two optical signals into two photocurrent signals after obtaining the two optical signals generated by the Mach-Zehnder interferometer; comparing the two photocurrent signals by a judgement unit to obtain a comparison voltage; in response to the comparison voltage being zero, keeping a bias voltage constant by a bias control unit; and in response to the comparison voltage not being zero, adjusting the bias voltage by a bias control unit according to the comparison voltage until the comparison voltage is zero.
G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
G01B 9/02015 - Interferometers characterised by the beam path configuration
The present invention belongs to the technical field of microorganisms, and relates to Clostridium ventriculi and the use thereof. The Clostridium ventriculi is Clostridium ventriculi SYSU-12 which is deposited in the China General Microbiological Culture Collection Center with a deposit number of CGMCC No. 27761 and a deposit date of 30 June 2023. Dominant strain SYSU-12 in feces is obtained by means of collecting a feces sample from a gastric cancer patient responding to PD-1 antibody treatment, and performing separation by means of anaerobic culture using the serial dilution method and then performing purification, and same is identified as Clostridium ventriculi by means of gram staining, microscopic examination, single colony morphology observation and molecular biology experiments. The Clostridium ventriculi and the component thereof provided can be used in the preparation of an immune activator, a tumor inhibitor and a corresponding drug or health food.
An edge-emitting single-mode laser provided with an oxidized aperture grating (211) and a preparation method therefor. The structure of the edge-emitting single-mode laser provided with an oxidized aperture grating (211) comprises, from top to bottom, a top electrode layer (111), a first contact layer (112), a first confinement layer (113), a first oxide layer (114), an active layer (121), a second oxide layer (131), a second confinement layer (132), a second contact layer (133), and a bottom electrode layer (134). A waveguide mode of the edge-emitting single-mode laser provided with an oxidized aperture grating (211) is confined by the first oxide layer (114) and the second oxide layer (131) forming a single-mode light-emitting aperture (311). The oxidized aperture grating (211) is transmitted inwards by an external etched grating, thereby spontaneously forming periodic refractive index modulation. The formed oxidized aperture grating (211) is not sensitive to etching depth, and grating position does not change along with etching depth, thereby facilitating acquisition of a repeatable and stable grating coupling coefficient. The oxidized aperture grating (211) confines a current injection window, so that device current injection efficiency is high and leakage current is small, thereby improving the performance of the edge-emitting single-mode laser.
Disclosed in the present invention are a multi-modal image matching method and system, and a terminal device and a storage medium. The method comprises: performing self-supervised feature extraction on an optical image and an SAR image, so as to obtain repeatable feature points between the optical image and the SAR image; on the basis of the repeatable feature points, segmenting the optical image and the SAR image into a first image block sequence, and performing feature extraction on the first image block sequence by means of a double-branch network, so as to respectively obtain a feature description vector of the optical image and a feature description vector of the SAR image, wherein the double-branch network comprises a first branch network used for extracting global features and a second branch network used for extracting local features; and on the basis of the feature description vectors, performing feature matching on the optical image and the SAR image, so as to obtain matching point pairs between the optical image and the SAR image. In the present invention, a two-stage training method is used, in which method training is performed first so as to obtain robust SAR-optical image feature description vectors, and learning is then performed in view of the feature description vectors so as to obtain feature points having high matching performance.
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
23.
BIFIDOBACTERIUM LONGUM SUBSP. INFANTIS, MICROBIAL AGENT AND USE THEREOF
The present disclosure relates to the field of cosmetics, and particularly to Bifidobacterium longum subsp. infantis, a microbial agent and use thereof. The present disclosure provides Bifidobacterium longum subsp. infantis, with preservation No. CGMCC NO. 27851. A species related to in the present disclosure can achieve efficacies of repairing, anti-inflammation, whitening and the like in food and beauty fields, has a wider range of efficacies, and can play a better role in the field of beauty and skin care.
Provided are a multimodal image matching method and system, terminal device, and storage medium. The method includes: performing self-supervised feature extraction on an optical image and a synthetic aperture radar (SAR) image to obtain a repetitive feature point between the optical image and the SAR image; segmenting the optical image and the SAR image into a first image block sequence based on the repetitive feature point, and performing feature extraction on the first image block sequence through a dual-branch network to obtain feature description vectors of the optical image and the SAR image respectively, where the dual-branch network includes a first branch network for extracting a global feature and a second branch network for extracting a local feature; and performing feature matching on the optical image and the SAR image based on the feature description vectors to obtain a matching point pair between the optical image and the SAR image.
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06T 7/174 - SegmentationEdge detection involving the use of two or more images
G06V 10/32 - Normalisation of the pattern dimensions
25.
INTEGRATED CIRCUIT WIRING METHOD AND SYSTEM, AND DEVICE AND MEDIUM
Disclosed in the present application are an integrated circuit routing method and system, and a device and a medium. The method comprises: acquiring an integrated circuit layout model; performing routing area generation processing on the integrated circuit layout model on the basis of a particle swarm optimization algorithm, so as to obtain a routing area; performing routing processing on the routing area on the basis of an improved A* search algorithm, so as to obtain a routing path; on the basis of the routing path, removing a redundant segment, so as to obtain a post-processed path; and performing dictionary conversion processing on the post-processed path, so as to obtain a routing layout. In the embodiments of the present application, a discrete particle swarm optimization algorithm can be used to reduce a routing search space, and a detailed routing area is determined by means of an improved A* search algorithm, thereby further enhancing routing speed, and improving the routing efficiency of an integrated circuit. The embodiments of the present application can be widely applied to the field of integrated circuits.
A method for determining a seam line of orthoimages, method for generating a mosaic image, device, and medium. The method includes: extracting valid area contours of a master image and a slave image respectively through a crawling search method; calculating difference values of valid pixels within an overlapping area between the master and slave images through a difference function, to obtain a difference map of the valid area; if there are more than two intersection points: calculating a position of a centroid of the overlapping area based on coordinates of each contour point of the intersection contour, determining a rectangular window centered on the centroid in the difference map, searching the rectangular window, and taking a position with a smallest difference value as an optimization end and the intersection points as optimization starts; determining, based on the optimization start and optimization end, a seam line through an A* algorithm.
Disclosed in the present application are an analog circuit netlist division method and system based on reinforcement learning. The method comprises: acquiring an analog circuit netlist; performing feature extraction processing on the analog circuit netlist, so as to obtain circuit features; performing classification processing on the circuit features on the basis of a hierarchical reinforcement learning algorithm, so as to obtain a classification result; and performing function labeling processing on the classification result, so as to obtain a modular circuit netlist. By means of the present application, automatic identification and classification can be performed on an analog circuit in combination with machine learning, so as to better adapt to different types of circuits and problems, thereby improving the quality and efficiency of division. The present application can be widely applied to the technical field of circuit division.
G06F 30/367 - Design verification, e.g. using simulation, simulation program with integrated circuit emphasis [SPICE], direct methods or relaxation methods
A laser processing method based on a chalcogenide material, and an integrated photonic device, which relate to the technical field of the processing of integrated photonic chips. The laser processing method based on a chalcogenide material comprises: acquiring a dielectric substrate of a preset size, and cleaning the dielectric substrate; preparing a uniform and dense sulfide thin film on the surface of the dielectric substrate; obtaining laser spots of a preset energy distribution pattern on the basis of a preset processing pattern; generating laser spot scanning parameters on the basis of the preset processing pattern; and performing etching-free laser oxidation processing on the sulfide thin film by means of the laser spots and according to the light spot scanning parameters, so as to obtain a chalcogenide integrated photonic device. The laser processing method based on a chalcogenide material can achieve the technical effects of significantly simplifying the processing procedures of an integrated photonic chip and improving the processing efficiency of the photonic chip.
Disclosed in the present application are an integrated light-emitting and detecting device and a manufacturing method therefor. The device successively comprises a transparent substrate, a transistor layer, a bottom electrode, a light-emitting layer and a top electrode, wherein the transistor layer comprises a first transistor and a second transistor, a first gate of the first transistor being connected to the bottom electrode via a first through hole, and a second source of the second transistor being connected to the bottom electrode via a second through hole. The first transistor is used for detecting a photocurrent or photovoltage generated by the light-emitting layer; the second transistor is used for controlling the light-emitting state of the light-emitting layer; the first through hole is used for providing an electric connection between the first gate and the bottom electrode, so as to equalize the voltage of the first gate and the voltage of the bottom electrode; the second through hole is used for providing an electric connection between the second source and the bottom electrode. In the embodiments of the present application, the detecting device having both a photoelectric detection function and an electroluminescent function has a small size and a simple structure, and is easy to manufacture and widely appliable to the field of photoelectric devices.
The present invention relates to the technical field of experiment apparatuses for concrete wastewater pipe corrosion. Disclosed are a concrete testing apparatus and method based on a load-corrosion coupling effect. The apparatus simulates a real environment for a wastewater pipe on the basis of a load-corrosion coupling effect, and also applies a mechanical load and a chemical corrosion effect to a concrete test block, and accelerates the corrosion of the concrete test block by means of exposing the concrete test block, thereby implementing research on mechanical characteristics of a concrete material under the load-corrosion coupling effect, and providing a sample basis for evaluation in regard to research on aging characteristics of the concrete wastewater pipe. Further disclosed in the present invention is a concrete testing method based on the testing apparatus.
The present invention provides a use of an Lck/Fyn-mediated STAT3 activation pathway as a target in the preparation or screening of a product. The product blocks the Lck/Fyn-mediated STAT3 activation pathway, inhibits differentiation of Th17 cells, and promotes transdifferentiation of the Th17 cells into Treg cells, thereby preventing or treating a Th17 cell-related immune disease. On the basis of the target, the present invention provides a use of an Lck/Fyn-mediated STAT3 activation blocker in the preparation of a product. The blocker is selected from an Lck/Fyn kinase inhibitor or a substance that specifically inhibits correct binding of Lck/Fyn and STAT3. The present invention provides a use of one or more biomaterials in the preparation of a product for preventing or treating the Th17 cell-related immune disease. The present invention also provides a drug for preventing or treating the Th17 cell-related immune disease and a treatment method thereof. Blocking Lck/Fyn-mediated STAT3 phosphorylation can be applied to the treatment of the Th17 cell-related immune disease or improvement of the capability to prevent an immune disease caused by the Th17 cells.
The present invention provides use of an Lck/Fyn-mediated STAT3 activation pathway as a target in preparing or screening a product. The product blocks the Lck/Fyn-mediated STAT3 activation pathway, inhibits the differentiation of Th17 cells, and promotes the differentiation of Th17 cells into Treg cells without affecting the differentiation of Th1 and Th2 cells, thereby preventing or treating Th17 cell-mediated immune diseases. According to the target, the present invention provides use of a blocker against Lck/Fyn-mediated STAT3 activation in preparing a product, and the blocker is selected from an Lck/Fyn kinase inhibitor or a substance that specifically inhibits the correct binding of Lck/Fyn to STAT3. The present invention provides use of one or more biological materials in preparing a product for preventing or treating a Th17 cell-mediated immune disease. The present invention further provides a medicament for preventing or treating a Th17 cell-mediated immune disease and a therapeutic method thereof.
Inversion lining rehabilitation equipment and method for pipe rehabilitation and reinforcement are disclosed. The equipment includes a working vehicle, a power supply unit, a matrix mixing device, a hose impregnating and flattening device, a hose inversion device and a movable bracket. The working vehicle has a box body and a vehicle-mounted support frame. The box body has a first accommodation space, which accommodates a dry hose material storage area, a matrix material storage area, a guide tube storage area, the power supply unit, the matrix mixing device and the hose impregnating and flattening device. The hose inversion device includes an inversion machine and an air pump. The movable bracket includes a bracket body. The top of the vehicle-mounted support frame and the top of the bracket body are respectively provided with a first mounting seat and a second mounting seat to be detachably connected to the inversion machine.
The present invention relates to the technical field of semiconductors. Disclosed are an edge-emitting single-mode laser having an oxide aperture waveguide and a manufacturing method therefor. An oxide aperture is fabricated as an optical confinement waveguide structure of a single-mode laser, and the partially insulated oxide aperture restricts a current injection window, so that the device has high current injection efficiency and a small leakage current. Additionally, a waveguide sidewall has lower scattering loss and has a more obvious suppression effect on high-order modes, facilitating achievement of a high-performance single-mode laser having extremely low threshold current density. A surface grating structure is further introduced, achieving the design of a single-mode laser having a high grating coupling coefficient; moreover, the preparation process is simple and reliable, and the repeatability is good, avoiding a complicated secondary epitaxial process, reducing the risk of chamber contamination, facilitating reproducible fabrication of high-quality gratings, and achieving multi-wavelength arrays.
Disclosed in the present invention are an interactive semantic-aware self-learning framework and an interpretable visual recognition method. The interactive semantic-aware self-learning framework comprises a teacher module and a student module, wherein the student module is used for visual recognition, and the teacher module is used for performing semantic instruction on the student module; the student module inputs a calculated shard-feature pair to the teacher module, and the teacher module outputs a calculated semantic-rich slice to the student module; the teacher module comprises a first encoder, a category-concept library and a similarity comparison sub-module; and the student module comprises a shard library, a second encoder and a feature selection sub-module. The present invention accurately captures features of different granularities, has great performance in terms of generalization and accuracy, enhances the interpretability regarding the alignment between an abstract semantic concept and a specific image area, and incorporates networks of different structures.
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/26 - Segmentation of patterns in the image fieldCutting or merging of image elements to establish the pattern region, e.g. clustering-based techniquesDetection of occlusion
G06V 10/40 - Extraction of image or video features
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
Disclosed are a staircase matrix code and a highly parallel low-latency ordered statistics decoding (OSD) method thereof. The staircase matrix code may be divided into a staircase generator matrix code and a staircase parity-check matrix code, and a corresponding generator matrix or parity-check matrix thereof has a staircase structure, or has a staircase structure after row and column permutation. Based on the special staircase structure, special highly parallel low-latency OSD can be employed to decode the staircase matrix code. Specifically, at least one reliable bit is selected from bits corresponding to each staircase to constitute an extended reliable basis, then a corresponding generator matrix or parity-check matrix has an upper triangular or lower triangular structure. Under the special triangular structure, parallel Gaussian elimination of all rows can be implemented, and then re-encoding and the like are executed to complete decoding. The staircase structure proposed in the present disclosure is combined with a special OSD design, thereby solving the deficiency of conventional OSD that Gaussian elimination can only be executed serially, and the staircase structure can be further combined with locally constrained OSD and the like to reduce re-encoding times, thereby implementing low-latency, low-complexity and high-reliability decoding.
H03M 13/11 - Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits using multiple parity bits
H03M 13/45 - Soft decoding, i.e. using symbol reliability information
37.
HYALURONIC ACID-BASED HYDROGEL PRECURSOR SOLUTION, HYALURONIC ACID-BASED HYDROGEL AND REPAIR MATERIAL THEREOF
The present invention relates to a hyaluronic acid-based hydrogel precursor solution, a hyaluronic acid-based hydrogel, a preparation method and a repair material thereof. The hyaluronic acid-based hydrogel precursor solution includes a component A and a component B; the component A is prepared by the following steps: step S1, mixing methacrylate group-modified hyaluronic acid with furfuryl amine for reaction, to obtain furan-methacrylate modified hyaluronic acid; step S2, mixing the furan-methacrylate modified hyaluronic acid with maleimide for reaction, to obtain hyaluronic acid modified with dual groups; and step S3, mixing the hyaluronic acid modified with dual groups with a photoinitiator and a solvent, to obtain the component A; and the component B is a mercapto polyethylene glycol solution.
Provided are a polypeptide, a design method of the polypeptide, and a product including the polypeptide for inhibiting Fusobacterium nucleatum (F. nucleatum) or a drug for preventing colorectal cancer. The polypeptide includes a hydrophobic amino acid and a charged amino acid, where an amino acid sequence of the polypeptide is distributed in a symmetrical structure. The polypeptide obtained in the present application includes natural amino acid residues as basic ingredients, and has inherent biocompatibility and biodegradability. The polypeptide can specifically kill F. nucleatum while exhibiting a low antimicrobial activity against other bacteria. Therefore, the polypeptide can be used to restrict a load level of F. nucleatum in vivo for a long time, thereby achieving the treatment and prevention of a variety of F. nucleatum-associated diseases. In addition, the polypeptide has advantages such as high sterilization rate, no residue, no pollution, highly-flexible molecular composition, and low immunogenicity.
Disclosed in the present application is a robot fault diagnosis method and apparatus suitable for special dangerous environments. The method comprises: performing fault prediction by using a kurtosis measurement-based fault prediction method, so as to obtain anomaly points; arranging measured vibration signals to obtain aligned target vibration signals; performing feature extraction processing on a source domain to obtain original fault features; inputting the original fault features into a preset model, and performing forward propagation on the preset model to obtain a degenerative feature layer; predicting the remaining useful lives for samples in the source domain, and extracting a highly mixed sample of the source domain and a target domain; acquiring a prediction error of the remaining useful lives of the samples in the source domain as a first training objective; acquiring a distribution difference error of the samples in the source domain and the target domain as a second training objective; and constructing an overall training objective, and performing training according to the overall training objective so as to obtain a target model. The present application can improve the accuracy of predicting the remaining useful lives for robots, and can be widely used in the technical field of robot fault diagnosis.
G01H 11/06 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means
G01H 17/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the other groups of this subclass
Disclosed in the present invention is a low-threshold on-chip Brillouin laser based on an FP cavity, comprising a first Sagnac annular reflector, a spiral waveguide, and a second Sagnac annular reflector which are made of a same waveguide, wherein one end of the first Sagnac annular reflector is used for inputting pump light and outputting Stokes light, the other end of the first Sagnac annular reflector is connected to one end of the spiral waveguide, and the other end of the spiral waveguide is connected to one end of the second Sagnac annular reflector. The present invention provides a structure for producing a low-threshold on-chip Brillouin laser based on an FP cavity. The structure is a standing wave cavity. A phase matching condition for causing Brillouin lasing can be satisfied by separately regulating the reflectivity of the first Sagnac annular reflector, the reflectivity of the second Sagnac annular reflector, and the length of the intermediate spiral waveguide, thereby implementing low-threshold Brillouin lasing. The present invention achieves a simple structure, does not require a suspended structure, and achieves a simple production process, high device robustness, and stable performance.
H01S 3/108 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using non-linear optical devices, e.g. exhibiting Brillouin or Raman scattering
41.
SPIRAL WINDING-BASED REPAIR DEVICE FOR UNDERGROUND PIPE
The present invention relates to the technical field of trenchless pipe repair. Disclosed is a spiral winding-based repair device for an underground pipe, comprising: a rotating frame and a plurality of rolling assemblies, wherein each rolling assembly comprises a locomotion wheel and material pressing rollers; and a first guide block, a second guide block and a third guide block, wherein the second guide block and the first guide block are spaced apart in the radial direction of the rotating frame, the second guide block is located on the outer side of the first guide block, the second guide block is located on the front side of the first guide block, the third guide block and the second guide block are spaced apart in the radial direction of the rotating frame, and a circumferential included angle is formed between the first guide block and the second guide block and between the second guide block and the third guide block in the circumferential direction of the rotating frame. Transformation of the angle and position of a stainless steel liner is carried out twice, and a buffer distance is provided for changes in radial lifting distance and guide angle in the circumferential direction of the rotating frame, such that the stainless steel liner can stably transition with a certain bend, ensuring that the stainless steel liner would not be damaged due to bending in the spiral winding process.
Provided are a coding method, a decoding method, a communication node, and a storage medium. The method includes determining to-be-coded attribute data of attribute information of a point cloud; determining a coding order of a current point in the point cloud; coding to-be-coded attribute data of the current point according to the coding order; and continuing to determine a coding order of a next current point in the point cloud, and coding to-be-coded attribute data of the next current point until all points in the point cloud are coded to obtain coded attribute data.
SUN YAT-SEN MEMORIAL HOSPITAL, SUN YAT-SEN UNIVERSITY (China)
Inventor
Huang, Kai
Wang, Jingfeng
Zhang, Yuling
Song, Rihui
Wang, Hongyuan
Cao, Zhengyu
Abstract
The present disclosure relates to the technical field of medical instrument control, and specifically to a remote control method and apparatus for a color Doppler ultrasonography probe, a system, an electronic device, and a medium. The method comprises: in a current control period, obtaining a target instantaneous velocity and a target instantaneous angular velocity of the tail end of a mechanical arm from a remote control device, wherein a color Doppler ultrasonography probe is installed at the tail end of the mechanical arm; and performing component division on the basis of a first instantaneous velocity, a first position, a first instantaneous angular velocity, and a first attitude of the tail end of the mechanical arm in the current control period, calculating a second position component and a second attitude component of the tail end of the mechanical arm in any one of a plurality of directions in a next control period on the basis of a constraint of the tail end of the mechanical arm, and determining a position and attitude of the tail end of the mechanical arm in the next control period, so as to control movement of the probe in the next control period. According to the present disclosure, the problem of shutdown of the mechanical arm caused by a plurality of target velocities that differ greatly being received at any time is solved, the responsiveness and flexibility of remote control of the color Doppler ultrasonography probe are improved, and the safety and stability of movement of the color Doppler ultrasonography probe are guaranteed.
The present invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a 1-aminobenzo[4,5]imidazo[1,2-a]pyrazine-3-formamide compound, and the preparation therefor and use thereof. The structure of the compound of the present invention is as shown in formula (I). The compound has a novel structure and is an adenosine receptor inhibitor, has good inhibitory activity on adenosine A2A receptors, has good subtype selectivity, and can be used as a targeted adenosine A2A receptor inhibitor for immunotherapy. By means of inhibiting the activity of the adenosine A2A receptor, the function of removing tumor cells by the immune system is released, so that the effect of treating tumors is achieved. Furthermore, the method for preparing the compound of the present invention is simple, uses cheap and easily available compounds as raw materials, has mild reaction conditions and high total yield and purity, can achieve dozens of grams of scale production, and supports the research of the clinical candidate adenosine A2A receptor inhibitor in the later stage.
The present invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a 1-aminobenzo[4,5]imidazo[1,2-a]pyrazine-3-formamide compound, and the preparation therefor and use thereof. The structure of the compound of the present invention is as shown in formula (I). The compound has a novel structure and is an adenosine receptor inhibitor, has good inhibitory activity on adenosine A2A receptors, has good subtype selectivity, and can be used as a targeted adenosine A2A receptor inhibitor for immunotherapy. By means of inhibiting the activity of the adenosine A2A receptor, the function of removing tumor cells by the immune system is released, so that the effect of treating tumors is achieved. Furthermore, the method for preparing the compound of the present invention is simple, uses cheap and easily available compounds as raw materials, has mild reaction conditions and high total yield and purity, can achieve dozens of grams of scale production, and supports the research of the clinical candidate adenosine A2A receptor inhibitor in the later stage.
Provided are the IFP35 protein family (interferon-induced 35 kDa protein (IFP35) and/or N-Myc interacting protein (NMI)), capable of being used as a marker for evaluating the efficacy of tumor immunotherapy, evaluating the prognosis of tumor immunotherapy and/or selecting a treatment scheme; by means of the IFP35 protein family (interferon-induced 35 kDa protein (IFP35) and/or N-Myc interacting protein (NMI)), and/or an IFP35 protein family (interferon-induced 35 kDa protein (IFP35) and/or N-Myc interacting protein (NMI)) promoter, the efficacy of tumor immunotherapy can be improved.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
An energy spectrum-dose measuring method and device is provided. The method includes: performing energy calibration on a spectrometer using a standard radiation source to obtain a conversion relation between a channel and an energy, where the conversion relation is represented by a calibration factor; measuring ray peaks of n radiation sources with different energies, and dividing energy of an obtained energy spectrum into n regions; performing spectrum collection on the n radiation sources according to the n regions to obtain n net energy spectra subjected to the energy calibration through the calibration factor; performing dose measurement on the n radiation sources sequentially to obtain n dose rates corresponding to the n net energy spectra; calculating a relationship between counting rates of the radiation sources in the n regions and corresponding dose rates; and calculating a full-spectrum dose rate according to a current dose rate of each region.
The present invention relates to the technical field of pipeline test. Disclosed are a reinforced concrete pipeline deterioration detection method and system, a device, and a storage medium. The method comprises: constructing an initial finite element pipeline model according to pipeline parameters of a pipeline to be tested; by means of the digital image technology, constructing a stress-strain field of said pipeline; determining the precision of the initial finite element pipeline model according to a strain cloud map of the stress-strain field, and adjusting the initial finite element pipeline model according to a determination result, so as to obtain a finite element pipeline model; and generating a typical load-displacement curve of said pipeline according to the finite element pipeline model, and calculating a deterioration degree index of said pipeline according to the typical load-displacement curve. By means of fusion of the digital image technology and the finite element technology, the present invention can comprehensively reflect the degree of damage of a structural body and accurately represent the deterioration condition of a long-term operation structure in real time, thereby improving the operation and maintenance safety for pipeline network systems.
The embodiments of the present application relate to the technical field of optical communications. Provided are a dual-optical-frequency comb generation system and method based on a communication algorithm. In the dual-optical-frequency comb generation system, a communication algorithm module is used for generating a preset time-domain signal by means of a pseudo-random binary sequence, and sending the preset time-domain signal to a dual-optical-frequency comb generation module, wherein in a frequency domain, the preset time-domain signal appears as two sets of comb teeth having a frequency difference; and the dual-optical-frequency comb generation module comprises a laser device, a signal generator, an electro-optic modulator and a microcavity, wherein an input end of the electro-optic modulator is connected to each of the laser device and the signal generator, an output end of the electro-optic modulator is connected to the microcavity, the laser device generates a continuous laser signal of a preset wavelength, the signal generator receives the preset time-domain signal and, on the basis of the preset time-domain signal, generates a dual-frequency-comb time-domain digital electrical signal, and on the basis of the dual-frequency-comb time-domain digital electrical signal, the electro-optic modulator modulates the continuous laser signal into a time-domain pseudo-random sequence optical signal corresponding to a dual-optical-frequency comb, and inputs the time-domain pseudo-random sequence optical signal into the microcavity.
Embodiments of the present application relate to the technical field of optical sensing, and provide an arrayed microcavity blood pressure detection system based on digital optical frequency dual combs. An input end of a light intensity modulator is connected to a laser and a waveform generator, separately, and an output end of the light intensity modulator, a polarization controller, and an on-chip optical microcavity array are sequentially connected; the light intensity modulator modulates single-frequency light on the basis of an electric modulation signal, to obtain an optical frequency dual-comb signal; the optical frequency dual-comb signal enters the on-chip optical microcavity array after passing through the polarization controller, the on-chip optical microcavity array is attached to a site of an artery to be measured, the on-chip optical microcavity array comprises a plurality of sensing units, each sensing unit generates an independent pulse signal, the on-chip optical microcavity array obtains a sensing signal on the basis of the optical frequency dual-comb signal and beating extrusion at the site of the artery to be measured, and a signal processing mechanism obtains blood pressure value information on the basis of the sensing signal. According to the detection system, the technical effect of improving the accuracy and convenience of blood pressure measurement can be achieved.
Embodiments of the present application relate to the technical field of spectrum analysis, and provide a mid-infrared spectrum analysis system and method based on a metasurface computational reconstruction. The mid-infrared spectrum analysis system comprises a metasurface core layer, a substrate, and a photoelectric detector array. The metasurface core layer and the substrate are stacked, and the metasurface core layer is provided with a metasurface structure array. The metasurface structure array comprises a plurality of metasurface structures, and spectrum responses of the plurality of metasurface structures are different. A spectrum response set of all of the metasurface structures in the metasurface structure array is a transmission matrix. The metasurface core layer is arranged above the photoelectric detector array, the photoelectric detector array comprises a plurality of photoelectric detectors, and the plurality of photoelectric detectors have one-to-one correspondence to the plurality of metasurface structures. The photoelectric detectors are configured to receive an optical signal generated by mid-infrared incident light to be measured after passing through the corresponding metasurface structures, and perform computational reconstruction on the basis of the transmission matrix of the metasurface structure array and the optical signal, to obtain spectrum information of the mid-infrared incident light to be measured.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
The present invention provides a method and system for analyzing a spatial probability based on a correspondence relationship between precipitation forecast and teleconnection. The method includes: acquiring a sample sequence of a precipitation forecast to be analyzed and a sample sequence of corresponding observation precipitation and climate indices; respectively calculating a forecast-observation correlation coefficient (FO-CC) and a climate index-observation precipitation teleconnection correlation coefficient (T-CC) of each grid according to the sample sequences, and categorizing each grid according to significance of the FO-CC and the climate index-observation precipitation T-CC; determining a correspondence relationship between the FO-CC and the T-CC according to a grid categorization result; calculating a spatial weight according to spatial coordinates of the grid for acquiring a spatial weight matrix; and calculating a spatial consistent probability where the FO-CC is significantly positive according to the spatial weight matrix and the correspondence relationship between the FO-CC and the T-CC.
SOUTHERN MARINE SCIENCE AND ENGINEERING GUANGDONG HAI) (China)
Inventor
Huang, Linchong
Huang, Xumin
Liang, Yu
Zhao, Chenyang
Lin, Cungang
Abstract
The present invention discloses a control apparatus and method for buoyancy adjustment of shield tunnel segments, wherein the inner end wall of anchor rod accommodating cavity is provided with a first slurry channel extending forward to the outer peripheral wall of anchor rod, the countersunk bolt is provided with a second slurry channel passing through the front and rear end faces of the countersunk bolt, and a locking structure is disposed in the accommodating cavity to lock the countersunk bolt in the accommodating cavity and connect the first slurry channel and second slurry channel. The entire construction process which can be carried out during the construction or operation period greatly reduces construction costs and space.
A method for constructing a relatively optimal air quality health index. The method comprises: acquiring air pollutants in a region, internal component data of the air pollutants, and health outcome data of the local population; by using a pseudo-Poisson distribution link function, sequentially constructing correlations among the air pollutants, the internal component data of the air pollutants, corresponding daily average concentrations, daily total population mortality, daily outpatient visits and daily inpatient admissions; constructing a multi-pollutant and multi-component Bayesian model on the basis of the air pollutants with the most severely harmful effects during hysteresis, the concentrations of components of the air pollutants, and health outcomes; estimating risk coefficients and weights of multiple pollutants and components, and calculating an excess health risk; establishing a comprehensive air quality health index, and on the basis of different health outcome data of the local population, calculating a plurality of comprehensive air quality health indexes which reflect the health risks associated with the different health outcome data of the local population; and performing comparative analysis on the plurality of comprehensive air quality health indexes, so as to select a relatively optimal air quality health index.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G06Q 10/063 - Operations research, analysis or management
G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks
54.
NEAR-INFRARED ZWITTERIONIC CYANINE DYE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
A near-infrared zwitterionic cyanine dye and a preparation method therefor and an application thereof. The near-infrared zwitterion takes a derivative having a cyanine dye structure as a fluorophore, and an amphoteric group is modified on a benzene ring, so that the compound has extremely high water solubility, and thus becomes a novel small-molecule fluorescent probe capable of being cleared via the kidney. Additionally, the compound also has good biocompatibility and optical stability, and as a fluorescent probe, can be used for carrying out early diagnosis, intraoperative navigation treatment, tissue and organ function evaluation, etc. on kidney diseases more accurately.
The present invention belongs to the technical field of biological medicine, and specifically relates to use of sodium formate in preparation of an anti-infective drug. The present invention has found through research that sodium formate can significantly increase the sensitivity of a bacterium to an antibiotic, so that the antibiotic that is originally ineffective or inefficient against a pathogenic bacterium becomes effective or efficient, thereby killing the bacterium and achieving an anti-infective effect. Sodium formate and an antibiotic are further prepared into an anti-infective composition, so that on the one hand, a significant anti-infective effect can be achieved under the condition of a low-concentration antibiotic, and on the other hand, the decreased use amount of the antibiotic can also significantly reduce the likelihood of a bacterium developing drug resistance; and sodium formate has been widely used in food and medicine with high safety.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
DEVELOPMENT RESEARCH INSTITUTE OF GUANGZHOU SMART CITY (China)
Inventor
Hu, Jianguo
Huang, Wenjun
Wu, Jin
Lin, Bingsheng
Li, Qiwen
Abstract
A knowledge fusion multi-modal interaction method and apparatus based on an improved alignment method. The method comprises: acquiring multi-modal data (S101); constructing a query transformation model (S102); on the basis of a multi-stream feature extraction method, performing improved processing on a vision transformer to obtain a multi-scale vision transformer (S103); on the basis of a joint text method, training the multi-scale vision transformer to obtain a target vision transformer (S104); freezing the target vision transformer, and on the basis of the target vision transformer, performing vision-text alignment training processing on the query transformation model to obtain a target query transformation model (S105); connecting the target query transformation model to a language model to obtain a knowledge fusion multi-modal interaction model (S106); and inputting the multi-modal data into the knowledge fusion multi-modal interaction model to obtain an interaction result (S107). In the embodiments of the present invention, the knowledge fusion multi-modal interaction model aligns visual representation with text representation, so that the mutual information between the visual representation and the text representation can be maximized, and the present invention can be widely applied to the technical field of artificial intelligence.
Disclosed is an external acceleration system for a biological denitrification process during wastewater treatment, including a biological denitrification mechanism, a denitrification acceleration mechanism, and a water circulation mechanism, where the biological denitrification mechanism includes a biological denitrification tank, a three-way valve, a wastewater assembly, and a water inlet pipe; the denitrification acceleration mechanism includes a denitrification accelerator and an assembly for enhancing the sulfur disproportionation reaction; the water circulation mechanism includes a first water delivery pump, a first water delivery pipe, a second water delivery pipe, and a second water delivery pump. The external acceleration system for a biological denitrification process during wastewater treatment spatially and temporally separates the sulfur disproportionation reaction process from the biological denitrification process so that the two processes do not interfere with each other and mutually promote the denitrification effect, which is beneficial to ensure the high efficiency and stability of the denitrification effect. The independently provided denitrification accelerator releases the coupling of the sulfur disproportionation reaction and the autotrophic denitrification reaction in the related art and has a high adaptability to various denitrification systems.
Provided are a gut bacterium strain and uses thereof, particularly, the gut bacterium strain with an accession number of GDMCC 62983 (Alistipes indistinctus Xia-1), and a method for the treatment and/or prevention of hyperuricemia using the gut bacterium strain of the present invention. The gut bacterium strain of the present invention has a therapeutic effect on lowering uric acid and a high safety, solving the technical problems of side effects caused by long-term intake of common drugs for hyperuricemia on the market, as well as the poor effect of controlling diet.
SUN YAT-SEN UNIVERSITY CANCER CENTER (THE AFFILIATED CANCER HOSPITAL OF SUN YAT-SEN UNIVERSITY, SUN YAT-SEN UNIVERSITY CANCER INSTITUTE) (China)
SUN YAT-SEN UNIVERSITY (China)
Inventor
Bei, Jinxin
Zeng, Yanni
Luo, Chunling
Abstract
Disclosed are a group of SNP markers related to assessment of the disease risk of nasopharyngeal carcinoma, the SNP markers comprising: rs2276868, rs3917410 and/or strong-linkage sites thereof. Also provided is the use of SNP marker detecting regents in the preparation of reagents for assessing the disease risk of nasopharyngeal carcinoma, which can be used for accurate assessment of the disease risk of nasopharyngeal carcinoma. Also provided is the use of a group of reagents used for detecting the expression of RPL14, SELE, NOTCH3 and FGFR3 genes in preparing a kit used for assessing the disease risk of nasopharyngeal carcinoma. Also provided is the use of the reagent for detecting the RPL14 gene in preparing a drug used for assessment of EBV infection and replication, disease-related phenotypes and prognosis of nasopharyngeal carcinoma.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A lining hose inverting machine and a using method thereof. The lining hose inverting machine comprises a launching cylinder, a first support, a second support, and a locking member. The launching cylinder comprises a cylinder body and a cylinder head, a hose entry is formed at the end of the cylinder body distant from the cylinder head, the cylinder head is a conically shaped cylinder and a hose exit is formed at the end of the cylinder head distant from the cylinder body, and the hose exit is located at the small end of the cylinder head and the cylinder head is provided with a flange-shaped stop disc; the stop disc is used for working in conjunction with a tightening member to fix an inversion opening of the hose; and the large end of the cylinder head is detachably connected to the cylinder body. The first support is fixedly connected to the cylinder body, the second support is rotatably connected to the first support, at least three extendable/retractable supporting legs are provided at the bottom of the second support, and the locking member is used for enabling the first support rotating to a target position relative to the second support to be fixedly connected to the second support. The lining hose inverting machine provided by the present application has high flexibility and maneuverability of adapting to different site conditions, and is beneficial to obtaining relatively high hose inverting speed during construction.
Provided are a Flavonifractor plautii Xia-2 strain and the use thereof. The Flavonifractor plautii Xia-2 strain has a deposit number of GDMCC No: 62984. The Flavonifractor plautii Xia-2 strain and a derivative, culture medium or composition thereof have the effect of preventing, ameliorating or treating atherosclerosis. The Flavonifractor plautii Xia-2 strain can effectively reduce the blood lipid level, inhibit the formation of atherosclerotic plaque, reduce the local inflammation level in the plaque, has no significant impact on the body weight and glycometabolism of an animal, also causes no damage to the liver functions and renal functions of an animal, and has relatively good safety.
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
62.
METHOD AND SYSTEM FOR ANALYZING PRECIPITATION NORMALIZATION BY GRADIENT-BASED PARAMETER OPTIMIZATION
The present invention provides a method and system for analyzing precipitation normalization by gradient-based parameter optimization. The method includes the following steps: acquiring precipitation data to be analyzed; constructing a normal transformation model to perform normal transformation on the precipitation data, to obtain a normal variable Z; letting the normal variable Z to obey normal distribution to construct a joint probability density function of the normal variable Z; constructing a likelihood function for parameter optimization based on the normal transformation model and the joint probability density function; deducing an analytic gradient vector of the likelihood function to optimize the likelihood function till a predetermined termination condition is satisfied, to obtain the optimum parameter enabling the maximum value of the likelihood function; and updating the normal transformation model based on the optimum parameter, and performing normal transformation and modeling analysis on the precipitation data to obtain a precipitation normalization analysis result.
Disclosed are a recombinant fusion antibody, and an antibody-drug conjugate and use thereof. The recombinant fusion antibody includes an antibody, at least one lysosome-targeting peptide, and at least one linker peptide, wherein the antibody is fused with the lysosome-targeting peptide to form the recombinant fusion antibody via the linker peptide; wherein the lysosome-targeting peptide is at least one selected from the group consisting of a lysosome-sorting signal peptide from a Golgi-localized, γ-adaptin ear-containing, ARF-binding protein (GGA), a lysosome-sorting signal peptide from a mannose 6-phosphate receptor (MPR), a lysosome-sorting signal peptide from a lysosome-associated membrane protein (LAMP), and a variant; wherein the variant is a peptide with one or more amino acids substituted, deleted, and/or added when aligned with the lysosome-sorting signal peptide from a GGA, a MPR or a LAMP. Compared with the original antibody, the internalization and lysosomal trafficking ability of the recombinant fusion antibody are significantly improved.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
64.
CLAMPING DEVICE, MECHANICAL ARM, AND METHOD FOR IDENTIFYING WORKPIECE
SUN YAT-SEN MEMORIAL HOSPITAL, SUN YAT-SEN UNIVERSITY (China)
Inventor
Huang, Kai
Wang, Jingfeng
Zhang, Yuling
Song, Rihui
Wang, Hongyuan
Cao, Zhengyu
Abstract
A clamping device, a mechanical arm, and a method for identifying a workpiece. The clamping device is provided with a fixation portion (10) and a clamping portion (20); the fixation portion (10) at least comprises a first fixation portion (11) and a second fixation portion (12) connected to the first fixation portion (11); the clamping portion (20) comprises a clamping base (21) and a clamping body (22); the first fixation portion (11) is fixedly connected to the tail end of a mechanical arm; the second fixation portion (12) is locked and fixed to the clamping base (21) by means of a quick release locking mechanism (30); the clamping body (22) is configured to clamp a workpiece.
The present invention relates to the technical fields of optical imaging and computer vision, and provides a bionic event imaging system and method. The system comprises: a lens or lens group used for converging light of an external environment; a controllable blinking module comprising a photomask and a control unit used for a closing/opening operation of the photomask, wherein the controllable blinking module is used for controlling to block or allow the incidence of the light of the external environment; a dynamic vision sensor used for measuring the brightness variation of an optical signal incident by the controllable blinking module, and triggering an event when the brightness variation exceeds a preset threshold, wherein the photomask correspondingly covers all or some of optical detection units in the dynamic vision sensor, and the event comprises coordinate information of a triggered pixel, time information and polarity information of the event; and an event processing unit used for performing solution according to an event flow generated by the dynamic vision sensor, and reconstructing and generating absolute light intensity images of a static scene and a dynamic scene in the external environment.
Disclosed in the present application are a file system metadata management method, a terminal device and a computer-readable storage medium. The data file management method of the present application comprises: on the basis of a path name corresponding to a file needing to be stored, performing encoding to obtain an initial key value format corresponding to the file; allocating a corresponding pre-allocated index value to the initial key value format so as to obtain a pre-allocated key value format; on the basis of the pre-allocated key value format, executing a merging operation on a pre-allocated index management space and a parent directory index management space corresponding to the pre-allocated key value format to obtain a target index management space; and obtaining a target key value format, and, on the basis of the target key value format, storing the file into a target storage structure.
The present application relates to the technical field of biology, and discloses a use of a reagent for knocking down or inhibiting SLC35F6 in preparation of a drug for activating AMPK. The inventor of the present application finds through research that SLC35F6 can be used as a new target for AMPK activity regulation, and finds through further research that an SLC35F6-ALPP complex inhibits the activity of AMPK. According to the present application, it is found that AMPK can be activated by knocking down SLC35F6 or ALPP, and targeting SLC35F6 or ALPP, selecting proper siRNA, and efficiently knocking down SLC35F6 or ALPP provide a new technical solution for the activation of AMPK. According to the present application, the regulation effect of SLC35F6 on the activity of AMPK is clarified for the first time, a new preventive and therapeutic drug research and development approach and drug action target are provided for diagnosis and treatment of diseases related to the activity of AMPK, and the present application has very important medicinal value.
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
Disclosed in the present invention are a skeleton sequence recognition method based on masked image autoencoders and a system. The method comprises the following steps: building a skeleton action recognition model, and using the skeleton action recognition model to recognize a skeleton sequence so as to predict the class of an action, the skeleton action recognition model comprising an M-layer spatial-temporal representation learning model and a one-layer classifier, the spatial-temporal representation learning model comprising two masked image autoencoders connected in parallel, and, by means of 1×1 convolution, output ends of the masked image autoencoders being subjected to residual connection with input ends thereof. The present invention uses the M-layer spatial-temporal representation learning model and the one-layer classifier to build the skeleton action recognition model, which uses a fine-grained dependency relationship between different skeleton joints for training and learning, is a highly-efficient skeleton sequence learning model, and is well generalized on different data sets.
Provided are a point cloud encoding method, a point cloud decoding method, a communication node, and a storage medium. The method includes predicting attribute information and generating a residual; quantizing the residual; performing run length encoding on the quantized residual to generate a run length value; for each run length value, selecting an entropy encoding strategy corresponding to a run length value to perform entropy encoding on the run length value; and processing the encoded run length value.
H04N 19/597 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using predictive coding specially adapted for multi-view video sequence encoding
H04N 19/13 - Adaptive entropy coding, e.g. adaptive variable length coding [AVLC] or context adaptive binary arithmetic coding [CABAC]
H04N 19/91 - Entropy coding, e.g. variable length coding [VLC] or arithmetic coding
The present application discloses an asynchronous circuit and an implementation method therefor, a chip, a medium, a product, and an electronic device. A control path of the asynchronous circuit comprises multiple stages of asynchronous handshake controllers; a first-stage asynchronous handshake controller is a source-end handshake controller having a pair of output handshake protocols, a last-stage asynchronous handshake controller is a receiving-end handshake controller having a pair of input handshake protocols, and other-stage asynchronous handshake controllers are two-phase single-rail handshake controllers each having a pair of input handshake protocols and a pair of output handshake protocols. The handshake signals of the asynchronous handshake controllers can be captured by using the propagation process of a main clock and a sub-clock, a data path and the control path are unified in clock analysis, and it is ensured to perform timing constraint on all circuits. Moreover, the relative timing constraint of the asynchronous circuit can be converted into static timing analysis that can be recognized by a traditional EDA tool, and an EDA tool is used to perform circuit optimization and timing constraint on the asynchronous circuit, thereby improving the efficiency of designing an asynchronous single-rail circuit.
Disclosed in the present invention is a water sample traceability management method based on an alliance blockchain ledger and a smart contract, comprising: collecting water sample data and processing same, and outputting a data identifier of the water sample data; uploading the data identifier to an alliance blockchain ledger to generate corresponding block information; designing a smart contract program, deploying the smart contract to an alliance blockchain, inputting the block information into the smart contract program, implementing data verification logic, and outputting smart contract verification information; recording the smart contract verification information in the alliance blockchain ledger, and outputting recorded data; and accessing the recorded data in the alliance blockchain ledger, analyzing the recorded data, outputting water quality testing data, and implementing data traceability. Further disclosed in the present invention is a water sample traceability management system based on the alliance blockchain ledger and the smart contract. According to the present invention, alliance blockchain ledger and smart contract technologies are used, decentralized management is achieved, data security is improved, and the whole-course trace leaving and traceability management of water samples are achieved.
222 or a biomarker-containing response group) and a quaternary ammonium-containing fragment are respectively linked to two ends of the derivative, so that not only high sensitivity and good biocompatibility and optical stability are achieved, but also good water solubility and renal clearance efficiency are achieved by means of cooperation with the substituent group or the fragment; the zwitterionic fluorescent compound can be used as a fluorescent probe to more accurately perform early diagnosis, intraoperative navigation treatment, tissue and organ function evaluation and the like on diseases.
C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 1/113 - General processes for the preparation of peptides by chemical modification of precursor peptides without change of the primary structure
SOUTHERN MARINE SCIENCE AND ENGINEERING GUANGDONG LABORATORY (ZHU HAI) (China)
Inventor
Huang, Linchong
Huang, Xumin
Liang, Yu
Zhao, Chenyang
Lin, Cungang
Abstract
A shield tunnel segment float control apparatus and a method. A first slurry channel (101) extending forwards to an outer peripheral wall of an anchor rod (1) accommodating cavity (10) is formed at an inner end wall thereof, a second slurry channel (20) axially penetrating through a front end face and a rear end face of a countersunk bolt (2) is formed, and a locking structure is provided in the accommodating cavity (10) to lock the countersunk head bolt (2) in the accommodating cavity and place the first slurry channel (101) and the second slurry channel (20) in communication. After the anchor rod integrally compresses the stratum via the through hole of the tunnel segment, slurry may be injected into the second slurry channel in the tunnel, causing the slurry to flow through the second slurry channel and the first slurry channel and then enter the stratum and diffuse; the anchor rod and the stratum of the area may be combined after the slurry solidifies, so as to provide tensile force for the anchor rod. A threaded connecting structure is then screwed into a preset distance along the countersunk head bolt in the tunnel, and pushed against the tunnel segment directly or by means of intermediate members, so that the tunnel segment is pushed to move downwards together to control upwards float of the tunnel segment. The whole construction process may be carried out during the construction period or the operation period, greatly reducing construction costs and construction space.
The present disclosure provides a method and system for high-precision localization of a surface of an object, the method including making marks with a pre-set distribution density on the surface of the object; photographing the marked object and numbering the marks in the image; acquiring relative position information about each mark on the surface of the object and establishing a corresponding relationship between mark numbers and mark position information; acquiring a real-time to be-measured image and detecting marks in the real-time to-be measured image; and calculating to obtain a position of the surface of the object corresponding to the current real-time to be-measured image. The system includes a mark making module, a numbering module, a mark position relationship module, a to-be measured image module and a physical quantity calculation module.
G01B 11/00 - Measuring arrangements characterised by the use of optical techniques
G01B 11/26 - Measuring arrangements characterised by the use of optical techniques for measuring angles or tapersMeasuring arrangements characterised by the use of optical techniques for testing the alignment of axes
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
75.
Split complementary base editing systems based on bimolecular deaminases and uses thereof
Disclosed are split complementary base editing systems based on bimolecular deaminases and uses thereof. A split complementary base editing system mainly includes base editing fusion proteins A and B that are from splitting at a deaminase domain embedded inside a Cas9 nickase (nCas9), and a guide RNA (gRNA). The present disclosures of split complementary cytosine base editing systems can greatly reduce Cas9-dependent and Cas9-independent off-target effects in the genome while maintaining robust on-target cytosine base editing. The present disclosures also provide the split complementary adenine base editing systems. The split complementary cytosine (adenine) base editing systems are widely applicable to various eukaryotic organisms, and can be used in crop genetic breeding, animal breed improvement, and even clinical treatment of human genetic diseases.
The present disclosure relates to the technical field of tactile feedback, which discloses a flexible vibration motor for providing tactile feedback, tactile feedback systems and an electronic device. The flexible vibration motor of the present disclosure includes a passive vibration signal transmission layer; and a vibration driving layer; the passive vibration signal transmission layer and the vibration driving layer are arranged adjacent to each other in a vertical direction; the vibration driving layer comprises an electrode array; the electrode array generates an electric field when a control signal is applied to the electrode array, and the passive vibration signal transmission layer is configured to generate induced charges induced by the electric field; the passive vibration signal transmission layer is further configured to generate vibration to provide tactile feedback under an interaction of the electric field and the induced charges.
A multi-order optical modulator and modulation method for on-chip optical matrix calculation are provided. The modulator includes: input waveguides, a 2×2 optical beam splitter, initial phase modulators, multi-order phase modulators, a 2×2 optical beam combiner, and an output waveguide; the input waveguides include a first input waveguide and a second input waveguide; the initial phase modulators include a first initial phase modulator and a second initial phase modulator; the multi-order phase modulators include a first multi-order phase modulator and a second multi-order phase modulator which are connected to the first initial phase modulator and the second initial phase modulator; and two input ends of the 2×2 optical beam combiner are respectively connected to the first multi-order phase modulator, the second multi-order phase modulator, and the output waveguide.
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
78.
APPLICATIONS OF CX-5461 IN TREATING IMMUNE REJECTION IN RENAL TRANSPLANTATION
The First Affiliated Hospital,Sun Yat-sen University (China)
Inventor
Chen, Hongbo
Shi, Peilin
Cheng, Fang
Liu, Longshan
Wang, Changxi
Bi, Zirong
Abstract
Applications of CX-5461 in preparing a medicine for treating renal transplant immune rejection and a medicine for treating immune rejection after renal transplantation are provided in the present disclosure. CX-5461 significantly reduces immune rejection in renal transplantation, and is used as a new immunosuppressant to treat renal allograft rejection, especially the acute rejection after renal transplantation.
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
79.
METHOD AND APPARATUS FOR GENERATING COMMON-SENSE AFTER-CLASS EXERCISE IN LOW-RESOURCE SCENARIO
The present invention relates to the technical field of artificial intelligence. A method and apparatus for generating a common-sense after-class exercise in a low-annotation resource scenario are disclosed, realizing automatic question generation by a machine. By means of transferring knowledge from a pre-trained language model, a large-scale knowledge base is provided; by means of decoupled learning of a small amount of data, key questioning factors are captured to achieve generalized generation in a manner of drawing inferences about other cases from one instance. The scale of parameter tuning is further reduced by means of prompt learning and the like. In addition, the present invention also constructs an adversarial framework-based validator to provide feedback on common-sense inferability, thereby generating grammatically correct and logically consistent results. The present invention can transfer rich semantic knowledge from external pre-trained semantic models, and by learning key questioning patterns in a decoupled prior dense latent space, effectively alleviates the problem of resource scarcity. The present invention also develops an adversarial framework with a differentiable validator to guide the generator to produce results with good common sense and logical consistency.
Disclosed is the use of a chimera in a targeted protein degradation technique. The chimera comprises a molecule that selectively binds to a protein of interest and a signal sequence that is directly or indirectly linked to the molecule and mediates the transport of the protein of interest to a lysosome. By constructing a signal-mediated lysosome-targeted chimera, a lysosome-targeted structural unit is used to promote endocytosis, so as to finally realize the enrichment and degradation of the chimera bound protein of interest in the lysosome.
The present disclosure relates to the technical field of molecular biology, and in particular to a method for preparing a Pt-based alloy/MOFs catalyst with high hydrogenation selectivity, and a preparation method thereof. The present disclosure prepares a Pt-based alloy/MOFs structure with Pt alloy particles uniformly supported on the surface of MOFs in one step through a simple solvothermal method, the preparation method of the present disclosure is simple, the reaction environment is not harsh and does not require a special atmosphere. The resulting product has a unique structure, with small metal particles, uniform distribution and not easy to lose, and it will not affect the catalytic activity of the metal. In terms of catalytic performance, the obtained Pt alloy/MOFs catalyst can catalytically hydrogenate cinnamaldehyde under normal temperature and pressure, and has excellent performance. In addition, the catalyst can also catalyze the selective hydrogenation of 3-nitrostyrene, catalyze the dehydrogenation of tetrahydroquinoline, which proves that the catalyst of the present disclosure has a wide range of applications.
C07C 45/62 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by hydrogenation of carbon-to-carbon double or triple bonds
B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
B01J 37/02 - Impregnation, coating or precipitation
B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
C07C 29/141 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of a —CHO group with hydrogen or hydrogen-containing gases
C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
C07C 209/36 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings
82.
METHODS AND MODIFIED NUCLEOSIDES FOR TREATING CORONAVIRUS INFECTIONS
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
SUN YAT-SEN UNIVERSITY (China)
Inventor
Zhang, Xumu
Guo, Deyin
Li, Guanguan
Cao, Liu
Li, Yingjun
Xu, Tiefeng
Ji, Yanxi
Zhou, Qifan
Yang, Yujian
Zhu, Tiaozhen
Abstract
Provided are methods for treating coronavirus infections by administering modified nucleosides, ester and amino acid ester prodrugs of nucleoside, their pharmaceutically acceptable salts, and drug combination thereof, of Formula (I). The compounds, combination, and methods provided are particularly useful for preventing, mitigating, or treating coronavirus infections or cytopathic effects resulting from the replication or reproduction of coronaviruses and their variants, including SARS-CoV-2.
Provided are methods for treating coronavirus infections by administering modified nucleosides, ester and amino acid ester prodrugs of nucleoside, their pharmaceutically acceptable salts, and drug combination thereof, of Formula (I). The compounds, combination, and methods provided are particularly useful for preventing, mitigating, or treating coronavirus infections or cytopathic effects resulting from the replication or reproduction of coronaviruses and their variants, including SARS-CoV-2.
A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
The present disclosure provides, for instance, a method of treating neuroinflammation including NMOSD in a subject, the method comprising administering to the subject a CRTH2 antagonist, thereby treating the neuroinflammation in the subject.
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Sun Yat-sen University Cancer Center (SYSUCC) (China)
Inventor
Zeng, Musheng
Sun, Cong
Feng, Guokai
Kang, Yinfeng
Abstract
Disclosed is a self-assembled nanoparticle containing a gHgL protein of an EB virus, a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide, wherein the first polypeptide comprises a gHgL protein and a first vector subunit, and the second polypeptide comprises a second vector subunit; the first vector subunit is 153-50A1, and the second vector subunit is 153-50B.4PT1; and the gHgL protein is linked to the first vector subunit through a linker. The gHgL protein of the EB virus is displayed on a surface of the self-assembled nanoparticle for the first time. The self-assembled nanoparticle has a larger particle size than the antigen (gHgL), a better antigen residence volume, and a thermal stability comparable to the antigen (gHgL). Moreover, since a larger number of gHgLs are displayed, the self-assembled nanoparticle can strongly stimulate more B cells and induce higher antibody titer.
The present disclosure relates to an optimization method of outlier data identification in a traffic emission quota allocation process. This method includes: constructing a traffic emission quota allocation model; calculating a unit output-input value for each input of each vehicle in a reference set D; identifying outlier vehicles by using a combination of isolation forest model-generalized super efficiency model; and removing final outlier vehicles from the reference set D to obtain a reference set D″ with the final outlier vehicles being removed.
Provided is an epigenetic editor, comprising a sequence-specific nucleic acid-binding domain, one or more transcriptional regulatory domains, and one or more phase separation domains. The epigenetic editor can modulate the transcription and/or expression of a target nucleic acid.
An intestinal strain and the use thereof. Specifically, an intestinal strain with the deposit number of GDMCC No: 62983, and the use of said intestinal strain in the preparation of a composition for treating/preventing hyperuricemia.
The present invention discloses a display module based on divergent beams with an asymmetrical divergence angle, which includes a light engine, a divergence-angle modulation element, a combiner, and a controller. The beams emitted from each projection point of the light engine are modulated, by the divergence-angle modulation element, into a bunch of beams with an asymmetrical divergence angle. Such a bunch of beams cover a rather large region on the combiner, by oblique incidence along one direction at a small divergence angle and by incidence along another direction at a large divergence angle. Then, the combiner converges incident beams from different projection points to corresponding viewing zones respectively, for a Maxwellian view 3D display or a Super multi-view 3D display.
G02B 30/33 - Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images by providing first and second parallax images to an observer’s left and right eyes of the autostereoscopic type involving directional light or back-light sources
89.
DATA PROCESSING METHOD AND APPARATUS, ELECTRONIC DEVICE, AND STORAGE MEDIUM
A data processing method and apparatus, an electronic device, and a storage medium are disclosed. The method may include determining a prediction table corresponding to attribute information of a point cloud; determining, a residual according to the prediction table; and encoding the residual and the index of the predicted value to form a code stream for transmission or storage.
2 is used as the position of the to-be-located node. In other words, a plurality of potential positions for the to-be-located node are calculated using multiple groups of RSSI data and these potential positions are then screened through calculation. Instead of directly processing the received RSSI data, the present disclosure processes the coordinate calculation values obtained based on the received RSSI data.
The present application belongs to the technical field of mathematical elevation models. Disclosed are a multi-source elevation data fusion method and apparatus, and a computer device and a medium. The method comprises: inputting acquired optical elevation data into a trained optical elevation error prediction model, so as to output an optical elevation error value and an optical elevation error weight graph, and inputting acquired radar elevation data into a trained radar elevation error prediction model, so as to output a radar elevation error value and a radar elevation error weight graph; correcting the optical elevation data according to the optical elevation error value, so as to obtain optical elevation data to be fused, and correcting the radar elevation data according to the radar elevation error value, so as to obtain radar elevation data to be fused; and according to the optical elevation error weight graph and the radar elevation error weight graph, performing weighted fusion on the optical elevation data to be fused and the radar elevation data to be fused, so as to obtain fused elevation data. The present application can achieve the effect of effectively improving the precision of fused elevation data.
Disclosed in the present invention is a time-accurate and real-time parallel I/O task control method. The method comprises: constructing an I/O device information model; constructing a task information model; according to the time predictability requirement of a system, performing time predictability modeling to construct an execution model; constructing a linear programming model according to the I/O device information model, the task information model and the execution model; modeling I/O time accuracy as a linearized optimization target according to a time-accurate quality model, and integrating the optimization target and the linear programming model to obtain a time accuracy optimization problem model; and solving the time accuracy optimization problem model to obtain an I/O allocation scheduling scheme, and performing real-time parallel I/O task control. By modeling the task information, the time predictability and the time accuracy optimization target as the linear programming model, the present invention can optimize the I/O time accuracy to the maximum extent, and can be widely applied to the technical field of computers.
Disclosed is a resource-aware task allocation method for a mixed-criticality partitioned real-time operating system, comprising: grouping tasks according to a resource access situation; according to the task grouping result, allocating high-criticality tasks under the condition that the allocation result is ensured to be schedulable in a high-criticality system mode; according to the task grouping result, allocating low-criticality tasks under the condition that the allocation result is ensured to be schedulable in a low-criticality system mode; and according to the allocated high-criticality tasks and low-criticality tasks, performing scheduling of system mode switching by using a task migration method so as to complete task allocation. The present invention can improve the overall schedulability of the system, and can be widely applied to the technical field of computers.
An intelligent 3D multi-target tracking method and system based on vehicle-cloud collaboration. The method comprises: performing detection on vehicle targets, acquiring a detected state of each vehicle in a scenario at an initial moment, and establishing initial trajectory information; according to target information of a tracking result in the scenario at the initial moment, predicting the states at a target moment by means of a Kalman filtering algorithm; performing detection on vehicle objects, acquiring a detected state of each vehicle, and then calculating data association degrees between detection box information of all detection objects at the target moment and predicted states of targets at the initial moment; according to the data association degrees, performing similarity matching on all the detection objects and prediction objects, so as to obtain a matching result; and performing target state management on the matching result until target tracking is completed.
A biosensor for implementing an FP-WA coupled mode includes a dielectric layer and a metal layer. The dielectric layer includes a plurality of dielectric grooves, and the plurality of dielectric grooves are periodically distributed at equal intervals. An opening width of the dielectric groove gradually decreases in a direction from a groove opening to a groove bottom. The metal layer is disposed on the dielectric layer and includes metal grooves that are in one-to-one correspondence with the dielectric grooves.
Provided are an acid protease AGP, a preparation method therefor, and a use thereof. The method comprises: inserting a target gene into an expression vector to construct a recombinant plasmid; transforming the recombinant plasmid into competent cells, then adding isopropylthiogalactopyranoside to induce expression; and performing purification to obtain acid protease AGP from a protein the expression of which has been induced. The acid protease AGP has a wide range of enzyme cleavage sites, comprising aspartic acid (Asp), glutamic acid (Glu), phenylalanine (Phe), histidine (His), lysine ( Lys) etc., which are highly complementary to Pepsin enzyme cleavage sites. The length of the peptides produced by AGP digestion is shorter than that of the peptides produced by Pepsin. The acid protease AGP still maintains strong activity under acidic conditions (pH 2.5), low temperatures, and the presence of small amounts of denaturants and reducing agents.
A multi-source elevation data fusion method including: inputting acquired optical elevation data into a trained optical elevation error prediction model to output an optical elevation error value and an optical elevation error weight map; inputting acquired radar elevation data into a trained radar elevation error prediction model to output a radar elevation error value and a radar elevation error weight map; correcting the optical elevation data based on the optical elevation error value to obtain optical elevation data to be fused; correcting the radar elevation data based on the radar elevation error value to obtain radar elevation data to be fused; performing weighted fusion on the optical elevation data to be fused and the radar elevation data to be fused based on the optical elevation error weight map and the radar elevation error weight map to obtain fused elevation data. This method efficiently enhances the accuracy of fused elevation data.
G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
G01S 13/86 - Combinations of radar systems with non-radar systems, e.g. sonar, direction finder
G06F 18/214 - Generating training patternsBootstrap methods, e.g. bagging or boosting
Provides a method for associating a precipitation forecast capability with a teleconnection effect based on coefficients of determination, including following steps: acquiring historical forecast precipitation data, observed precipitation data, and a climate index sample sequence, and obtaining original sample data; establishing regression equations of observed precipitation and forecast precipitation, observed precipitation and a climate index, and observed precipitation and a union set of the forecast precipitation and the climate index, and calculating corresponding coefficients of determination through the regression equations; calculating variances explained by the forecast precipitation alone, by the climate index alone, and by the forecast precipitation and the climate index alone; processing the variances by means of bootstrapping to obtain a reference distribution of the variances; and comparing the original sample data with the reference distribution of the variances to obtain an association result of the precipitation forecast capability and the teleconnection effect.
Disclosed is a combination of peptide linkers for protein covalent self-assembly using a spontaneous isopeptide bond, including a peptide linker 1 and a peptide linker 2. The peptide linker 1 contains a peptide chain having an amino acid sequence as shown in SEQ ID NO: 5, and the peptide linker 2 contains any one or more of peptide chains having amino acid sequences as shown in SEQ ID NOs: 11, 13, 14, and 46. The present disclosure constructs a novel protein self-assembly system based on an isopeptide bond, which effectively solves the problem of low binding efficiency of an existing SpyTag/SpyCatcher system, can significantly improve the reaction efficiency of molecules or components fused to a peptide tag and polypeptide thereof, and has a binding efficiency stronger than that of a SpyTag003/SpyCatcher003 system.
A multiple-views-one-eye display method with sub-pixels as basic display units. The sub-pixels of a display device are taken as basic display units. Through beam-splitting modulation of a grating device, lights from different sub-pixel groups are respectively guided to different viewing zones where a viewer's pupil(s) is located. Different sub-pixel groups project different perspective views of a target scene. Thus with more than one perspective views being received by a same pupil of a viewer, monocular focusable 3D scene display gets implemented. During the display, light beams from sub-pixels of different colors intersect at each display point and overlap to be a colorful spatial light-spot. The light from different colored sub pixels propagates along their respective directions and overlap on each display object point to form spatial colored light points.
H04N 13/32 - Image reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using arrays of controllable light sourcesImage reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using moving apertures or moving light sources
H04N 13/383 - Image reproducers using viewer tracking for tracking with gaze detection, i.e. detecting the lines of sight of the viewer's eyes
patents
