Abstract

Provided are a coding method, a decoding method, a communication node, and a storage medium. The method includes determining to-be-coded attribute data of attribute information of a point cloud; determining a coding order of a current point in the point cloud; coding to-be-coded attribute data of the current point according to the coding order; and continuing to determine a coding order of a next current point in the point cloud, and coding to-be-coded attribute data of the next current point until all points in the point cloud are coded to obtain coded attribute data.

IPC Classes  ?

• H04N 19/136 - Incoming video signal characteristics or properties

Abstract

The present disclosure relates to the technical field of medical instrument control, and specifically to a remote control method and apparatus for a color Doppler ultrasonography probe, a system, an electronic device, and a medium. The method comprises: in a current control period, obtaining a target instantaneous velocity and a target instantaneous angular velocity of the tail end of a mechanical arm from a remote control device, wherein a color Doppler ultrasonography probe is installed at the tail end of the mechanical arm; and performing component division on the basis of a first instantaneous velocity, a first position, a first instantaneous angular velocity, and a first attitude of the tail end of the mechanical arm in the current control period, calculating a second position component and a second attitude component of the tail end of the mechanical arm in any one of a plurality of directions in a next control period on the basis of a constraint of the tail end of the mechanical arm, and determining a position and attitude of the tail end of the mechanical arm in the next control period, so as to control movement of the probe in the next control period. According to the present disclosure, the problem of shutdown of the mechanical arm caused by a plurality of target velocities that differ greatly being received at any time is solved, the responsiveness and flexibility of remote control of the color Doppler ultrasonography probe are improved, and the safety and stability of movement of the color Doppler ultrasonography probe are guaranteed.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• B25J 9/00 - Programme-controlled manipulators
• B25J 13/00 - Controls for manipulators

Abstract

The present invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a 1-aminobenzo[4,5]imidazo[1,2-a]pyrazine-3-formamide compound, and the preparation therefor and use thereof. The structure of the compound of the present invention is as shown in formula (I). The compound has a novel structure and is an adenosine receptor inhibitor, has good inhibitory activity on adenosine A2A receptors, has good subtype selectivity, and can be used as a targeted adenosine A2A receptor inhibitor for immunotherapy. By means of inhibiting the activity of the adenosine A2A receptor, the function of removing tumor cells by the immune system is released, so that the effect of treating tumors is achieved. Furthermore, the method for preparing the compound of the present invention is simple, uses cheap and easily available compounds as raw materials, has mild reaction conditions and high total yield and purity, can achieve dozens of grams of scale production, and supports the research of the clinical candidate adenosine A2A receptor inhibitor in the later stage. The present invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a 1-aminobenzo[4,5]imidazo[1,2-a]pyrazine-3-formamide compound, and the preparation therefor and use thereof. The structure of the compound of the present invention is as shown in formula (I). The compound has a novel structure and is an adenosine receptor inhibitor, has good inhibitory activity on adenosine A2A receptors, has good subtype selectivity, and can be used as a targeted adenosine A2A receptor inhibitor for immunotherapy. By means of inhibiting the activity of the adenosine A2A receptor, the function of removing tumor cells by the immune system is released, so that the effect of treating tumors is achieved. Furthermore, the method for preparing the compound of the present invention is simple, uses cheap and easily available compounds as raw materials, has mild reaction conditions and high total yield and purity, can achieve dozens of grams of scale production, and supports the research of the clinical candidate adenosine A2A receptor inhibitor in the later stage.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

Abstract

The present invention relates to the use of the IFP35 protein family in the evaluation of the efficacy of tumor immunotherapy. The present invention discloses, for the first time, that the IFP35 protein family (interferon-induced 35 kDa protein (IFP35) and/or N-Myc interacting protein (NMI)) can be used as a marker for evaluating the efficacy of tumor immunotherapy, evaluating the prognosis of tumor immunotherapy and/or selecting a treatment scheme, and by means of the IFP35 protein family (interferon-induced 35 kDa protein (IFP35) and/or N-Myc interacting protein (NMI)), and/or an IFP35 protein family (interferon-induced 35 kDa protein (IFP35) and/or N-Myc interacting protein (NMI)) promoter, the efficacy of tumor immunotherapy can be improved.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C12N 15/86 - Viral vectors
• A61K 40/00 - Cellular immunotherapy
• A61P 35/00 - Antineoplastic agents

Abstract

An energy spectrum-dose measuring method and device is provided. The method includes: performing energy calibration on a spectrometer using a standard radiation source to obtain a conversion relation between a channel and an energy, where the conversion relation is represented by a calibration factor; measuring ray peaks of n radiation sources with different energies, and dividing energy of an obtained energy spectrum into n regions; performing spectrum collection on the n radiation sources according to the n regions to obtain n net energy spectra subjected to the energy calibration through the calibration factor; performing dose measurement on the n radiation sources sequentially to obtain n dose rates corresponding to the n net energy spectra; calculating a relationship between counting rates of the radiation sources in the n regions and corresponding dose rates; and calculating a full-spectrum dose rate according to a current dose rate of each region.

IPC Classes  ?

• G01T 1/40 - Stabilisation of spectrometers
• G01T 1/02 - Dosimeters

Abstract

The present invention relates to the technical field of pipeline test. Disclosed are a reinforced concrete pipeline deterioration detection method and system, a device, and a storage medium. The method comprises: constructing an initial finite element pipeline model according to pipeline parameters of a pipeline to be tested; by means of the digital image technology, constructing a stress-strain field of said pipeline; determining the precision of the initial finite element pipeline model according to a strain cloud map of the stress-strain field, and adjusting the initial finite element pipeline model according to a determination result, so as to obtain a finite element pipeline model; and generating a typical load-displacement curve of said pipeline according to the finite element pipeline model, and calculating a deterioration degree index of said pipeline according to the typical load-displacement curve. By means of fusion of the digital image technology and the finite element technology, the present invention can comprehensively reflect the degree of damage of a structural body and accurately represent the deterioration condition of a long-term operation structure in real time, thereby improving the operation and maintenance safety for pipeline network systems.

IPC Classes  ?

• G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]

Abstract

The embodiments of the present application relate to the technical field of optical communications. Provided are a dual-optical-frequency comb generation system and method based on a communication algorithm. In the dual-optical-frequency comb generation system, a communication algorithm module is used for generating a preset time-domain signal by means of a pseudo-random binary sequence, and sending the preset time-domain signal to a dual-optical-frequency comb generation module, wherein in a frequency domain, the preset time-domain signal appears as two sets of comb teeth having a frequency difference; and the dual-optical-frequency comb generation module comprises a laser device, a signal generator, an electro-optic modulator and a microcavity, wherein an input end of the electro-optic modulator is connected to each of the laser device and the signal generator, an output end of the electro-optic modulator is connected to the microcavity, the laser device generates a continuous laser signal of a preset wavelength, the signal generator receives the preset time-domain signal and, on the basis of the preset time-domain signal, generates a dual-frequency-comb time-domain digital electrical signal, and on the basis of the dual-frequency-comb time-domain digital electrical signal, the electro-optic modulator modulates the continuous laser signal into a time-domain pseudo-random sequence optical signal corresponding to a dual-optical-frequency comb, and inputs the time-domain pseudo-random sequence optical signal into the microcavity.

IPC Classes  ?

• H04B 10/50 - Transmitters
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light

Abstract

Embodiments of the present application relate to the technical field of optical sensing, and provide an arrayed microcavity blood pressure detection system based on digital optical frequency dual combs. An input end of a light intensity modulator is connected to a laser and a waveform generator, separately, and an output end of the light intensity modulator, a polarization controller, and an on-chip optical microcavity array are sequentially connected; the light intensity modulator modulates single-frequency light on the basis of an electric modulation signal, to obtain an optical frequency dual-comb signal; the optical frequency dual-comb signal enters the on-chip optical microcavity array after passing through the polarization controller, the on-chip optical microcavity array is attached to a site of an artery to be measured, the on-chip optical microcavity array comprises a plurality of sensing units, each sensing unit generates an independent pulse signal, the on-chip optical microcavity array obtains a sensing signal on the basis of the optical frequency dual-comb signal and beating extrusion at the site of the artery to be measured, and a signal processing mechanism obtains blood pressure value information on the basis of the sensing signal. According to the detection system, the technical effect of improving the accuracy and convenience of blood pressure measurement can be achieved.

IPC Classes  ?

• A61B 5/021 - Measuring pressure in heart or blood vessels
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Embodiments of the present application relate to the technical field of spectrum analysis, and provide a mid-infrared spectrum analysis system and method based on a metasurface computational reconstruction. The mid-infrared spectrum analysis system comprises a metasurface core layer, a substrate, and a photoelectric detector array. The metasurface core layer and the substrate are stacked, and the metasurface core layer is provided with a metasurface structure array. The metasurface structure array comprises a plurality of metasurface structures, and spectrum responses of the plurality of metasurface structures are different. A spectrum response set of all of the metasurface structures in the metasurface structure array is a transmission matrix. The metasurface core layer is arranged above the photoelectric detector array, the photoelectric detector array comprises a plurality of photoelectric detectors, and the plurality of photoelectric detectors have one-to-one correspondence to the plurality of metasurface structures. The photoelectric detectors are configured to receive an optical signal generated by mid-infrared incident light to be measured after passing through the corresponding metasurface structures, and perform computational reconstruction on the basis of the transmission matrix of the metasurface structure array and the optical signal, to obtain spectrum information of the mid-infrared incident light to be measured.

IPC Classes  ?

• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
• G01J 3/28 - Investigating the spectrum

Abstract

The present invention provides a method and system for analyzing a spatial probability based on a correspondence relationship between precipitation forecast and teleconnection. The method includes: acquiring a sample sequence of a precipitation forecast to be analyzed and a sample sequence of corresponding observation precipitation and climate indices; respectively calculating a forecast-observation correlation coefficient (FO-CC) and a climate index-observation precipitation teleconnection correlation coefficient (T-CC) of each grid according to the sample sequences, and categorizing each grid according to significance of the FO-CC and the climate index-observation precipitation T-CC; determining a correspondence relationship between the FO-CC and the T-CC according to a grid categorization result; calculating a spatial weight according to spatial coordinates of the grid for acquiring a spatial weight matrix; and calculating a spatial consistent probability where the FO-CC is significantly positive according to the spatial weight matrix and the correspondence relationship between the FO-CC and the T-CC.

IPC Classes  ?

• G01W 1/10 - Devices for predicting weather conditions

Abstract

The present invention discloses a control apparatus and method for buoyancy adjustment of shield tunnel segments, wherein the inner end wall of anchor rod accommodating cavity is provided with a first slurry channel extending forward to the outer peripheral wall of anchor rod, the countersunk bolt is provided with a second slurry channel passing through the front and rear end faces of the countersunk bolt, and a locking structure is disposed in the accommodating cavity to lock the countersunk bolt in the accommodating cavity and connect the first slurry channel and second slurry channel. The entire construction process which can be carried out during the construction or operation period greatly reduces construction costs and space.

IPC Classes  ?

• E21D 11/08 - Lining with building materials with preformed concrete slabs
• E21D 20/02 - Setting anchoring-bolts with provisions for grouting

Abstract

A method for constructing a relatively optimal air quality health index. The method comprises: acquiring air pollutants in a region, internal component data of the air pollutants, and health outcome data of the local population; by using a pseudo-Poisson distribution link function, sequentially constructing correlations among the air pollutants, the internal component data of the air pollutants, corresponding daily average concentrations, daily total population mortality, daily outpatient visits and daily inpatient admissions; constructing a multi-pollutant and multi-component Bayesian model on the basis of the air pollutants with the most severely harmful effects during hysteresis, the concentrations of components of the air pollutants, and health outcomes; estimating risk coefficients and weights of multiple pollutants and components, and calculating an excess health risk; establishing a comprehensive air quality health index, and on the basis of different health outcome data of the local population, calculating a plurality of comprehensive air quality health indexes which reflect the health risks associated with the different health outcome data of the local population; and performing comparative analysis on the plurality of comprehensive air quality health indexes, so as to select a relatively optimal air quality health index.

IPC Classes  ?

• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• G16C 20/70 - Machine learning, data mining or chemometrics
• G06Q 50/26 - Government or public services
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G06Q 10/063 - Operations research, analysis or management
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

A near-infrared zwitterionic cyanine dye and a preparation method therefor and an application thereof. The near-infrared zwitterion takes a derivative having a cyanine dye structure as a fluorophore, and an amphoteric group is modified on a benzene ring, so that the compound has extremely high water solubility, and thus becomes a novel small-molecule fluorescent probe capable of being cleared via the kidney. Additionally, the compound also has good biocompatibility and optical stability, and as a fluorescent probe, can be used for carrying out early diagnosis, intraoperative navigation treatment, tissue and organ function evaluation, etc. on kidney diseases more accurately.

IPC Classes  ?

• C07F 9/572 - Five-membered rings
• C09B 23/10 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an even number of CH groups
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• A61K 49/00 - Preparations for testing in vivo
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present invention belongs to the technical field of biological medicine, and specifically relates to use of sodium formate in preparation of an anti-infective drug. The present invention has found through research that sodium formate can significantly increase the sensitivity of a bacterium to an antibiotic, so that the antibiotic that is originally ineffective or inefficient against a pathogenic bacterium becomes effective or efficient, thereby killing the bacterium and achieving an anti-infective effect. Sodium formate and an antibiotic are further prepared into an anti-infective composition, so that on the one hand, a significant anti-infective effect can be achieved under the condition of a low-concentration antibiotic, and on the other hand, the decreased use amount of the antibiotic can also significantly reduce the likelihood of a bacterium developing drug resistance; and sodium formate has been widely used in food and medicine with high safety.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 31/04 - Antibacterial agents

Abstract

A knowledge fusion multi-modal interaction method and apparatus based on an improved alignment method. The method comprises: acquiring multi-modal data (S101); constructing a query transformation model (S102); on the basis of a multi-stream feature extraction method, performing improved processing on a vision transformer to obtain a multi-scale vision transformer (S103); on the basis of a joint text method, training the multi-scale vision transformer to obtain a target vision transformer (S104); freezing the target vision transformer, and on the basis of the target vision transformer, performing vision-text alignment training processing on the query transformation model to obtain a target query transformation model (S105); connecting the target query transformation model to a language model to obtain a knowledge fusion multi-modal interaction model (S106); and inputting the multi-modal data into the knowledge fusion multi-modal interaction model to obtain an interaction result (S107). In the embodiments of the present invention, the knowledge fusion multi-modal interaction model aligns visual representation with text representation, so that the mutual information between the visual representation and the text representation can be maximized, and the present invention can be widely applied to the technical field of artificial intelligence.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

Disclosed is an external acceleration system for a biological denitrification process during wastewater treatment, including a biological denitrification mechanism, a denitrification acceleration mechanism, and a water circulation mechanism, where the biological denitrification mechanism includes a biological denitrification tank, a three-way valve, a wastewater assembly, and a water inlet pipe; the denitrification acceleration mechanism includes a denitrification accelerator and an assembly for enhancing the sulfur disproportionation reaction; the water circulation mechanism includes a first water delivery pump, a first water delivery pipe, a second water delivery pipe, and a second water delivery pump. The external acceleration system for a biological denitrification process during wastewater treatment spatially and temporally separates the sulfur disproportionation reaction process from the biological denitrification process so that the two processes do not interfere with each other and mutually promote the denitrification effect, which is beneficial to ensure the high efficiency and stability of the denitrification effect. The independently provided denitrification accelerator releases the coupling of the sulfur disproportionation reaction and the autotrophic denitrification reaction in the related art and has a high adaptability to various denitrification systems.

IPC Classes  ?

• C02F 3/30 - Aerobic and anaerobic processes
• C02F 101/16 - Nitrogen compounds, e.g. ammonia

Abstract

Provided are a gut bacterium strain and uses thereof, particularly, the gut bacterium strain with an accession number of GDMCC 62983 (Alistipes indistinctus Xia-1), and a method for the treatment and/or prevention of hyperuricemia using the gut bacterium strain of the present invention. The gut bacterium strain of the present invention has a therapeutic effect on lowering uric acid and a high safety, solving the technical problems of side effects caused by long-term intake of common drugs for hyperuricemia on the market, as well as the poor effect of controlling diet.

IPC Classes  ?

• A61K 35/741 - Probiotics
• A61P 19/06 - Antigout agents, e.g. antihyperuricemic or uricosuric agents

Abstract

Disclosed are a group of SNP markers related to assessment of the disease risk of nasopharyngeal carcinoma, the SNP markers comprising: rs2276868, rs3917410 and/or strong-linkage sites thereof. Also provided is the use of SNP marker detecting regents in the preparation of reagents for assessing the disease risk of nasopharyngeal carcinoma, which can be used for accurate assessment of the disease risk of nasopharyngeal carcinoma. Also provided is the use of a group of reagents used for detecting the expression of RPL14, SELE, NOTCH3 and FGFR3 genes in preparing a kit used for assessing the disease risk of nasopharyngeal carcinoma. Also provided is the use of the reagent for detecting the RPL14 gene in preparing a drug used for assessment of EBV infection and replication, disease-related phenotypes and prognosis of nasopharyngeal carcinoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6858 - Allele-specific amplification
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• G16B 20/50 - Mutagenesis
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

A lining hose inverting machine and a using method thereof. The lining hose inverting machine comprises a launching cylinder, a first support, a second support, and a locking member. The launching cylinder comprises a cylinder body and a cylinder head, a hose entry is formed at the end of the cylinder body distant from the cylinder head, the cylinder head is a conically shaped cylinder and a hose exit is formed at the end of the cylinder head distant from the cylinder body, and the hose exit is located at the small end of the cylinder head and the cylinder head is provided with a flange-shaped stop disc; the stop disc is used for working in conjunction with a tightening member to fix an inversion opening of the hose; and the large end of the cylinder head is detachably connected to the cylinder body. The first support is fixedly connected to the cylinder body, the second support is rotatably connected to the first support, at least three extendable/retractable supporting legs are provided at the bottom of the second support, and the locking member is used for enabling the first support rotating to a target position relative to the second support to be fixedly connected to the second support. The lining hose inverting machine provided by the present application has high flexibility and maneuverability of adapting to different site conditions, and is beneficial to obtaining relatively high hose inverting speed during construction.

IPC Classes  ?

• F16L 55/18 - Appliances for use in repairing pipes
• F16L 55/162 - Devices for covering leaks in pipes or hoses, e.g. hose-menders from inside the pipe

Abstract

Provided are a Flavonifractor plautii Xia-2 strain and the use thereof. The Flavonifractor plautii Xia-2 strain has a deposit number of GDMCC No: 62984. The Flavonifractor plautii Xia-2 strain and a derivative, culture medium or composition thereof have the effect of preventing, ameliorating or treating atherosclerosis. The Flavonifractor plautii Xia-2 strain can effectively reduce the blood lipid level, inhibit the formation of atherosclerotic plaque, reduce the local inflammation level in the plaque, has no significant impact on the body weight and glycometabolism of an animal, also causes no damage to the liver functions and renal functions of an animal, and has relatively good safety.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/741 - Probiotics
• A61P 3/06 - Antihyperlipidemics
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms

Abstract

The present invention provides a method and system for analyzing precipitation normalization by gradient-based parameter optimization. The method includes the following steps: acquiring precipitation data to be analyzed; constructing a normal transformation model to perform normal transformation on the precipitation data, to obtain a normal variable Z; letting the normal variable Z to obey normal distribution to construct a joint probability density function of the normal variable Z; constructing a likelihood function for parameter optimization based on the normal transformation model and the joint probability density function; deducing an analytic gradient vector of the likelihood function to optimize the likelihood function till a predetermined termination condition is satisfied, to obtain the optimum parameter enabling the maximum value of the likelihood function; and updating the normal transformation model based on the optimum parameter, and performing normal transformation and modeling analysis on the precipitation data to obtain a precipitation normalization analysis result.

IPC Classes  ?

• G06F 17/14 - Fourier, Walsh or analogous domain transformations
• G01W 1/10 - Devices for predicting weather conditions

Abstract

Disclosed are a recombinant fusion antibody, and an antibody-drug conjugate and use thereof. The recombinant fusion antibody includes an antibody, at least one lysosome-targeting peptide, and at least one linker peptide, wherein the antibody is fused with the lysosome-targeting peptide to form the recombinant fusion antibody via the linker peptide; wherein the lysosome-targeting peptide is at least one selected from the group consisting of a lysosome-sorting signal peptide from a Golgi-localized, γ-adaptin ear-containing, ARF-binding protein (GGA), a lysosome-sorting signal peptide from a mannose 6-phosphate receptor (MPR), a lysosome-sorting signal peptide from a lysosome-associated membrane protein (LAMP), and a variant; wherein the variant is a peptide with one or more amino acids substituted, deleted, and/or added when aligned with the lysosome-sorting signal peptide from a GGA, a MPR or a LAMP. Compared with the original antibody, the internalization and lysosomal trafficking ability of the recombinant fusion antibody are significantly improved.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 35/00 - Antineoplastic agents
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes

Abstract

A clamping device, a mechanical arm, and a method for identifying a workpiece. The clamping device is provided with a fixation portion (10) and a clamping portion (20); the fixation portion (10) at least comprises a first fixation portion (11) and a second fixation portion (12) connected to the first fixation portion (11); the clamping portion (20) comprises a clamping base (21) and a clamping body (22); the first fixation portion (11) is fixedly connected to the tail end of a mechanical arm; the second fixation portion (12) is locked and fixed to the clamping base (21) by means of a quick release locking mechanism (30); the clamping body (22) is configured to clamp a workpiece.

IPC Classes  ?

• B25J 18/00 - Arms
• B25J 15/00 - Gripping heads
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

The present invention relates to the technical fields of optical imaging and computer vision, and provides a bionic event imaging system and method. The system comprises: a lens or lens group used for converging light of an external environment; a controllable blinking module comprising a photomask and a control unit used for a closing/opening operation of the photomask, wherein the controllable blinking module is used for controlling to block or allow the incidence of the light of the external environment; a dynamic vision sensor used for measuring the brightness variation of an optical signal incident by the controllable blinking module, and triggering an event when the brightness variation exceeds a preset threshold, wherein the photomask correspondingly covers all or some of optical detection units in the dynamic vision sensor, and the event comprises coordinate information of a triggered pixel, time information and polarity information of the event; and an event processing unit used for performing solution according to an event flow generated by the dynamic vision sensor, and reconstructing and generating absolute light intensity images of a static scene and a dynamic scene in the external environment.

IPC Classes  ?

• H04N 23/61 - Control of cameras or camera modules based on recognised objects

Abstract

Disclosed in the present application are a file system metadata management method, a terminal device and a computer-readable storage medium. The data file management method of the present application comprises: on the basis of a path name corresponding to a file needing to be stored, performing encoding to obtain an initial key value format corresponding to the file; allocating a corresponding pre-allocated index value to the initial key value format so as to obtain a pre-allocated key value format; on the basis of the pre-allocated key value format, executing a merging operation on a pre-allocated index management space and a parent directory index management space corresponding to the pre-allocated key value format to obtain a target index management space; and obtaining a target key value format, and, on the basis of the target key value format, storing the file into a target storage structure.

IPC Classes  ?

• G06F 16/11 - File system administration, e.g. details of archiving or snapshots

Abstract

The present application relates to the technical field of biology, and discloses a use of a reagent for knocking down or inhibiting SLC35F6 in preparation of a drug for activating AMPK. The inventor of the present application finds through research that SLC35F6 can be used as a new target for AMPK activity regulation, and finds through further research that an SLC35F6-ALPP complex inhibits the activity of AMPK. According to the present application, it is found that AMPK can be activated by knocking down SLC35F6 or ALPP, and targeting SLC35F6 or ALPP, selecting proper siRNA, and efficiently knocking down SLC35F6 or ALPP provide a new technical solution for the activation of AMPK. According to the present application, the regulation effect of SLC35F6 on the activity of AMPK is clarified for the first time, a new preventive and therapeutic drug research and development approach and drug action target are provided for diagnosis and treatment of diseases related to the activity of AMPK, and the present application has very important medicinal value.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Disclosed in the present invention are a skeleton sequence recognition method based on masked image autoencoders and a system. The method comprises the following steps: building a skeleton action recognition model, and using the skeleton action recognition model to recognize a skeleton sequence so as to predict the class of an action, the skeleton action recognition model comprising an M-layer spatial-temporal representation learning model and a one-layer classifier, the spatial-temporal representation learning model comprising two masked image autoencoders connected in parallel, and, by means of 1×1 convolution, output ends of the masked image autoencoders being subjected to residual connection with input ends thereof. The present invention uses the M-layer spatial-temporal representation learning model and the one-layer classifier to build the skeleton action recognition model, which uses a fine-grained dependency relationship between different skeleton joints for training and learning, is a highly-efficient skeleton sequence learning model, and is well generalized on different data sets.

IPC Classes  ?

• G06V 40/20 - Movements or behaviour, e.g. gesture recognition
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

Provided are a point cloud encoding method, a point cloud decoding method, a communication node, and a storage medium. The method includes predicting attribute information and generating a residual; quantizing the residual; performing run length encoding on the quantized residual to generate a run length value; for each run length value, selecting an entropy encoding strategy corresponding to a run length value to perform entropy encoding on the run length value; and processing the encoded run length value.

IPC Classes  ?

• H04N 19/597 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using predictive coding specially adapted for multi-view video sequence encoding
• H04N 19/13 - Adaptive entropy coding, e.g. adaptive variable length coding [AVLC] or context adaptive binary arithmetic coding [CABAC]
• H04N 19/91 - Entropy coding, e.g. variable length coding [VLC] or arithmetic coding
• H04N 19/93 - Run-length coding

Abstract

The present application discloses an asynchronous circuit and an implementation method therefor, a chip, a medium, a product, and an electronic device. A control path of the asynchronous circuit comprises multiple stages of asynchronous handshake controllers; a first-stage asynchronous handshake controller is a source-end handshake controller having a pair of output handshake protocols, a last-stage asynchronous handshake controller is a receiving-end handshake controller having a pair of input handshake protocols, and other-stage asynchronous handshake controllers are two-phase single-rail handshake controllers each having a pair of input handshake protocols and a pair of output handshake protocols. The handshake signals of the asynchronous handshake controllers can be captured by using the propagation process of a main clock and a sub-clock, a data path and the control path are unified in clock analysis, and it is ensured to perform timing constraint on all circuits. Moreover, the relative timing constraint of the asynchronous circuit can be converted into static timing analysis that can be recognized by a traditional EDA tool, and an EDA tool is used to perform circuit optimization and timing constraint on the asynchronous circuit, thereby improving the efficiency of designing an asynchronous single-rail circuit.

IPC Classes  ?

• G06F 15/78 - Architectures of general purpose stored program computers comprising a single central processing unit
• G06F 9/48 - Program initiatingProgram switching, e.g. by interrupt

Abstract

Disclosed in the present invention is a water sample traceability management method based on an alliance blockchain ledger and a smart contract, comprising: collecting water sample data and processing same, and outputting a data identifier of the water sample data; uploading the data identifier to an alliance blockchain ledger to generate corresponding block information; designing a smart contract program, deploying the smart contract to an alliance blockchain, inputting the block information into the smart contract program, implementing data verification logic, and outputting smart contract verification information; recording the smart contract verification information in the alliance blockchain ledger, and outputting recorded data; and accessing the recorded data in the alliance blockchain ledger, analyzing the recorded data, outputting water quality testing data, and implementing data traceability. Further disclosed in the present invention is a water sample traceability management system based on the alliance blockchain ledger and the smart contract. According to the present invention, alliance blockchain ledger and smart contract technologies are used, decentralized management is achieved, data security is improved, and the whole-course trace leaving and traceability management of water samples are achieved.

IPC Classes  ?

• G06F 21/64 - Protecting data integrity, e.g. using checksums, certificates or signatures

Abstract

222 or a biomarker-containing response group) and a quaternary ammonium-containing fragment are respectively linked to two ends of the derivative, so that not only high sensitivity and good biocompatibility and optical stability are achieved, but also good water solubility and renal clearance efficiency are achieved by means of cooperation with the substituent group or the fragment; the zwitterionic fluorescent compound can be used as a fluorescent probe to more accurately perform early diagnosis, intraoperative navigation treatment, tissue and organ function evaluation and the like on diseases.

IPC Classes  ?

• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07K 5/103 - Tetrapeptides the side chain of the first amino acid being acyclic, e.g. Gly, Ala
• C07K 1/113 - General processes for the preparation of peptides by chemical modification of precursor peptides without change of the primary structure
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• A61K 49/00 - Preparations for testing in vivo

Abstract

A shield tunnel segment float control apparatus and a method. A first slurry channel (101) extending forwards to an outer peripheral wall of an anchor rod (1) accommodating cavity (10) is formed at an inner end wall thereof, a second slurry channel (20) axially penetrating through a front end face and a rear end face of a countersunk bolt (2) is formed, and a locking structure is provided in the accommodating cavity (10) to lock the countersunk head bolt (2) in the accommodating cavity and place the first slurry channel (101) and the second slurry channel (20) in communication. After the anchor rod integrally compresses the stratum via the through hole of the tunnel segment, slurry may be injected into the second slurry channel in the tunnel, causing the slurry to flow through the second slurry channel and the first slurry channel and then enter the stratum and diffuse; the anchor rod and the stratum of the area may be combined after the slurry solidifies, so as to provide tensile force for the anchor rod. A threaded connecting structure is then screwed into a preset distance along the countersunk head bolt in the tunnel, and pushed against the tunnel segment directly or by means of intermediate members, so that the tunnel segment is pushed to move downwards together to control upwards float of the tunnel segment. The whole construction process may be carried out during the construction period or the operation period, greatly reducing construction costs and construction space.

IPC Classes  ?

• E21D 11/08 - Lining with building materials with preformed concrete slabs
• E21D 21/00 - Anchoring-bolts for roof, floor, or shaft-lining protection
• E21D 20/00 - Setting anchoring-bolts
• E21D 20/02 - Setting anchoring-bolts with provisions for grouting

Abstract

The present disclosure provides a method and system for high-precision localization of a surface of an object, the method including: making marks with a pre-set distribution density on the surface of the object; photographing the marked object and numbering the marks in the image; acquiring relative position information about each mark on the surface of the object and establishing a corresponding relationship between mark numbers and mark position information; acquiring a real-time to-be-measured image and detecting marks in the real-time to-be-measured image; and calculating to obtain a position of the surface of the object corresponding to the current real-time to-be-measured image. The system includes: a mark making module, a numbering module, a mark position relationship module, a to-be-measured image module and a physical quantity calculation module.

IPC Classes  ?

• G01B 11/00 - Measuring arrangements characterised by the use of optical techniques
• G01B 11/26 - Measuring arrangements characterised by the use of optical techniques for measuring angles or tapersMeasuring arrangements characterised by the use of optical techniques for testing the alignment of axes
• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods

Abstract

Disclosed are split complementary base editing systems based on bimolecular deaminases and uses thereof. A split complementary base editing system mainly includes base editing fusion proteins A and B that are from splitting at a deaminase domain embedded inside a Cas9 nickase (nCas9), and a guide RNA (gRNA). The present disclosures of split complementary cytosine base editing systems can greatly reduce Cas9-dependent and Cas9-independent off-target effects in the genome while maintaining robust on-target cytosine base editing. The present disclosures also provide the split complementary adenine base editing systems. The split complementary cytosine (adenine) base editing systems are widely applicable to various eukaryotic organisms, and can be used in crop genetic breeding, animal breed improvement, and even clinical treatment of human genetic diseases.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present disclosure relates to the technical field of tactile feedback, which discloses a flexible vibration motor for providing tactile feedback, tactile feedback systems and an electronic device. The flexible vibration motor of the present disclosure includes a passive vibration signal transmission layer; and a vibration driving layer; the passive vibration signal transmission layer and the vibration driving layer are arranged adjacent to each other in a vertical direction; the vibration driving layer comprises an electrode array; the electrode array generates an electric field when a control signal is applied to the electrode array, and the passive vibration signal transmission layer is configured to generate induced charges induced by the electric field; the passive vibration signal transmission layer is further configured to generate vibration to provide tactile feedback under an interaction of the electric field and the induced charges.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A multi-order optical modulator and modulation method for on-chip optical matrix calculation are provided. The modulator includes: input waveguides, a 2×2 optical beam splitter, initial phase modulators, multi-order phase modulators, a 2×2 optical beam combiner, and an output waveguide; the input waveguides include a first input waveguide and a second input waveguide; the initial phase modulators include a first initial phase modulator and a second initial phase modulator; the multi-order phase modulators include a first multi-order phase modulator and a second multi-order phase modulator which are connected to the first initial phase modulator and the second initial phase modulator; and two input ends of the 2×2 optical beam combiner are respectively connected to the first multi-order phase modulator, the second multi-order phase modulator, and the output waveguide.

IPC Classes  ?

• G01R 31/317 - Testing of digital circuits
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

Applications of CX-5461 in preparing a medicine for treating renal transplant immune rejection and a medicine for treating immune rejection after renal transplantation are provided in the present disclosure. CX-5461 significantly reduces immune rejection in renal transplantation, and is used as a new immunosuppressant to treat renal allograft rejection, especially the acute rejection after renal transplantation.

IPC Classes  ?

• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

The present invention relates to the technical field of artificial intelligence. A method and apparatus for generating a common-sense after-class exercise in a low-annotation resource scenario are disclosed, realizing automatic question generation by a machine. By means of transferring knowledge from a pre-trained language model, a large-scale knowledge base is provided; by means of decoupled learning of a small amount of data, key questioning factors are captured to achieve generalized generation in a manner of drawing inferences about other cases from one instance. The scale of parameter tuning is further reduced by means of prompt learning and the like. In addition, the present invention also constructs an adversarial framework-based validator to provide feedback on common-sense inferability, thereby generating grammatically correct and logically consistent results. The present invention can transfer rich semantic knowledge from external pre-trained semantic models, and by learning key questioning patterns in a decoupled prior dense latent space, effectively alleviates the problem of resource scarcity. The present invention also develops an adversarial framework with a differentiable validator to guide the generator to produce results with good common sense and logical consistency.

IPC Classes  ?

• G06F 16/33 - Querying

Abstract

Disclosed is the use of a chimera in a targeted protein degradation technique. The chimera comprises a molecule that selectively binds to a protein of interest and a signal sequence that is directly or indirectly linked to the molecule and mediates the transport of the protein of interest to a lysosome. By constructing a signal-mediated lysosome-targeted chimera, a lysosome-targeted structural unit is used to promote endocytosis, so as to finally realize the enrichment and degradation of the chimera bound protein of interest in the lysosome.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum

Abstract

The present disclosure relates to the technical field of molecular biology, and in particular to a method for preparing a Pt-based alloy/MOFs catalyst with high hydrogenation selectivity, and a preparation method thereof. The present disclosure prepares a Pt-based alloy/MOFs structure with Pt alloy particles uniformly supported on the surface of MOFs in one step through a simple solvothermal method, the preparation method of the present disclosure is simple, the reaction environment is not harsh and does not require a special atmosphere. The resulting product has a unique structure, with small metal particles, uniform distribution and not easy to lose, and it will not affect the catalytic activity of the metal. In terms of catalytic performance, the obtained Pt alloy/MOFs catalyst can catalytically hydrogenate cinnamaldehyde under normal temperature and pressure, and has excellent performance. In addition, the catalyst can also catalyze the selective hydrogenation of 3-nitrostyrene, catalyze the dehydrogenation of tetrahydroquinoline, which proves that the catalyst of the present disclosure has a wide range of applications.

IPC Classes  ?

• C07C 45/62 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by hydrogenation of carbon-to-carbon double or triple bonds
• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/04 - Mixing
• B01J 37/06 - Washing
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C07C 29/141 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of a —CHO group with hydrogen or hydrogen-containing gases
• C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
• C07C 209/36 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings

Abstract

Provided are methods for treating coronavirus infections by administering modified nucleosides, ester and amino acid ester prodrugs of nucleoside, their pharmaceutically acceptable salts, and drug combination thereof, of Formula (I). The compounds, combination, and methods provided are particularly useful for preventing, mitigating, or treating coronavirus infections or cytopathic effects resulting from the replication or reproduction of coronaviruses and their variants, including SARS-CoV-2. Provided are methods for treating coronavirus infections by administering modified nucleosides, ester and amino acid ester prodrugs of nucleoside, their pharmaceutically acceptable salts, and drug combination thereof, of Formula (I). The compounds, combination, and methods provided are particularly useful for preventing, mitigating, or treating coronavirus infections or cytopathic effects resulting from the replication or reproduction of coronaviruses and their variants, including SARS-CoV-2.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present disclosure provides, for instance, a method of treating neuroinflammation including NMOSD in a subject, the method comprising administering to the subject a CRTH2 antagonist, thereby treating the neuroinflammation in the subject.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 37/02 - Immunomodulators

Abstract

Disclosed is a self-assembled nanoparticle containing a gHgL protein of an EB virus, a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide, wherein the first polypeptide comprises a gHgL protein and a first vector subunit, and the second polypeptide comprises a second vector subunit; the first vector subunit is 153-50A1, and the second vector subunit is 153-50B.4PT1; and the gHgL protein is linked to the first vector subunit through a linker. The gHgL protein of the EB virus is displayed on a surface of the self-assembled nanoparticle for the first time. The self-assembled nanoparticle has a larger particle size than the antigen (gHgL), a better antigen residence volume, and a thermal stability comparable to the antigen (gHgL). Moreover, since a larger number of gHgLs are displayed, the self-assembled nanoparticle can strongly stimulate more B cells and induce higher antibody titer.

IPC Classes  ?

• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/20 - Antivirals for DNA viruses

Abstract

The present disclosure relates to an optimization method of outlier data identification in a traffic emission quota allocation process. This method includes: constructing a traffic emission quota allocation model; calculating a unit output-input value for each input of each vehicle in a reference set D; identifying outlier vehicles by using a combination of isolation forest model-generalized super efficiency model; and removing final outlier vehicles from the reference set D to obtain a reference set D″ with the final outlier vehicles being removed.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

Provided is an epigenetic editor, comprising a sequence-specific nucleic acid-binding domain, one or more transcriptional regulatory domains, and one or more phase separation domains. The epigenetic editor can modulate the transcription and/or expression of a target nucleic acid.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

An intestinal strain and the use thereof. Specifically, an intestinal strain with the deposit number of GDMCC No: 62983, and the use of said intestinal strain in the preparation of a composition for treating/preventing hyperuricemia.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/741 - Probiotics
• A61P 19/06 - Antigout agents, e.g. antihyperuricemic or uricosuric agents
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
• A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
• A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
• C12R 1/01 - Bacteria or actinomycetales

Abstract

The present invention discloses a display module based on divergent beams with an asymmetrical divergence angle, which includes a light engine, a divergence-angle modulation element, a combiner, and a controller. The beams emitted from each projection point of the light engine are modulated, by the divergence-angle modulation element, into a bunch of beams with an asymmetrical divergence angle. Such a bunch of beams cover a rather large region on the combiner, by oblique incidence along one direction at a small divergence angle and by incidence along another direction at a large divergence angle. Then, the combiner converges incident beams from different projection points to corresponding viewing zones respectively, for a Maxwellian view 3D display or a Super multi-view 3D display.

IPC Classes  ?

• G02B 30/33 - Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images by providing first and second parallax images to an observer’s left and right eyes of the autostereoscopic type involving directional light or back-light sources

Abstract

A data processing method and apparatus, an electronic device, and a storage medium are disclosed. The method may include determining a prediction table corresponding to attribute information of a point cloud; determining, a residual according to the prediction table; and encoding the residual and the index of the predicted value to form a code stream for transmission or storage.

IPC Classes  ?

• G06T 9/00 - Image coding

Abstract

2 is used as the position of the to-be-located node. In other words, a plurality of potential positions for the to-be-located node are calculated using multiple groups of RSSI data and these potential positions are then screened through calculation. Instead of directly processing the received RSSI data, the present disclosure processes the coordinate calculation values obtained based on the received RSSI data.

IPC Classes  ?

• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management
• H04W 84/18 - Self-organising networks, e.g. ad hoc networks or sensor networks

Abstract

The present application belongs to the technical field of mathematical elevation models. Disclosed are a multi-source elevation data fusion method and apparatus, and a computer device and a medium. The method comprises: inputting acquired optical elevation data into a trained optical elevation error prediction model, so as to output an optical elevation error value and an optical elevation error weight graph, and inputting acquired radar elevation data into a trained radar elevation error prediction model, so as to output a radar elevation error value and a radar elevation error weight graph; correcting the optical elevation data according to the optical elevation error value, so as to obtain optical elevation data to be fused, and correcting the radar elevation data according to the radar elevation error value, so as to obtain radar elevation data to be fused; and according to the optical elevation error weight graph and the radar elevation error weight graph, performing weighted fusion on the optical elevation data to be fused and the radar elevation data to be fused, so as to obtain fused elevation data. The present application can achieve the effect of effectively improving the precision of fused elevation data.

IPC Classes  ?

• G06F 18/25 - Fusion techniques
• G01S 13/08 - Systems for measuring distance only

Abstract

Disclosed in the present invention is a time-accurate and real-time parallel I/O task control method. The method comprises: constructing an I/O device information model; constructing a task information model; according to the time predictability requirement of a system, performing time predictability modeling to construct an execution model; constructing a linear programming model according to the I/O device information model, the task information model and the execution model; modeling I/O time accuracy as a linearized optimization target according to a time-accurate quality model, and integrating the optimization target and the linear programming model to obtain a time accuracy optimization problem model; and solving the time accuracy optimization problem model to obtain an I/O allocation scheduling scheme, and performing real-time parallel I/O task control. By modeling the task information, the time predictability and the time accuracy optimization target as the linear programming model, the present invention can optimize the I/O time accuracy to the maximum extent, and can be widely applied to the technical field of computers.

IPC Classes  ?

• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

Abstract

Disclosed is a resource-aware task allocation method for a mixed-criticality partitioned real-time operating system, comprising: grouping tasks according to a resource access situation; according to the task grouping result, allocating high-criticality tasks under the condition that the allocation result is ensured to be schedulable in a high-criticality system mode; according to the task grouping result, allocating low-criticality tasks under the condition that the allocation result is ensured to be schedulable in a low-criticality system mode; and according to the allocated high-criticality tasks and low-criticality tasks, performing scheduling of system mode switching by using a task migration method so as to complete task allocation. The present invention can improve the overall schedulability of the system, and can be widely applied to the technical field of computers.

IPC Classes  ?

• G06F 9/50 - Allocation of resources, e.g. of the central processing unit [CPU]

Abstract

An intelligent 3D multi-target tracking method and system based on vehicle-cloud collaboration. The method comprises: performing detection on vehicle targets, acquiring a detected state of each vehicle in a scenario at an initial moment, and establishing initial trajectory information; according to target information of a tracking result in the scenario at the initial moment, predicting the states at a target moment by means of a Kalman filtering algorithm; performing detection on vehicle objects, acquiring a detected state of each vehicle, and then calculating data association degrees between detection box information of all detection objects at the target moment and predicted states of targets at the initial moment; according to the data association degrees, performing similarity matching on all the detection objects and prediction objects, so as to obtain a matching result; and performing target state management on the matching result until target tracking is completed.

IPC Classes  ?

• G06V 20/54 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects of traffic, e.g. cars on the road, trains or boats

Abstract

A biosensor for implementing an FP-WA coupled mode includes a dielectric layer and a metal layer. The dielectric layer includes a plurality of dielectric grooves, and the plurality of dielectric grooves are periodically distributed at equal intervals. An opening width of the dielectric groove gradually decreases in a direction from a groove opening to a groove bottom. The metal layer is disposed on the dielectric layer and includes metal grooves that are in one-to-one correspondence with the dielectric grooves.

IPC Classes  ?

• G01N 21/552 - Attenuated total reflection
• G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Provided are an acid protease AGP, a preparation method therefor, and a use thereof. The method comprises: inserting a target gene into an expression vector to construct a recombinant plasmid; transforming the recombinant plasmid into competent cells, then adding isopropylthiogalactopyranoside to induce expression; and performing purification to obtain acid protease AGP from a protein the expression of which has been induced. The acid protease AGP has a wide range of enzyme cleavage sites, comprising aspartic acid (Asp), glutamic acid (Glu), phenylalanine (Phe), histidine (His), lysine ( Lys) etc., which are highly complementary to Pepsin enzyme cleavage sites. The length of the peptides produced by AGP digestion is shorter than that of the peptides produced by Pepsin. The acid protease AGP still maintains strong activity under acidic conditions (pH 2.5), low temperatures, and the presence of small amounts of denaturants and reducing agents.

IPC Classes  ?

• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• C12N 15/57 - Hydrolases (3) acting on peptide bonds (3.4)
• C12N 9/62 - Proteinases derived from fungi from Aspergillus
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A multi-source elevation data fusion method including: inputting acquired optical elevation data into a trained optical elevation error prediction model to output an optical elevation error value and an optical elevation error weight map; inputting acquired radar elevation data into a trained radar elevation error prediction model to output a radar elevation error value and a radar elevation error weight map; correcting the optical elevation data based on the optical elevation error value to obtain optical elevation data to be fused; correcting the radar elevation data based on the radar elevation error value to obtain radar elevation data to be fused; performing weighted fusion on the optical elevation data to be fused and the radar elevation data to be fused based on the optical elevation error weight map and the radar elevation error weight map to obtain fused elevation data. This method efficiently enhances the accuracy of fused elevation data.

IPC Classes  ?

• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
• G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
• G01S 13/86 - Combinations of radar systems with non-radar systems, e.g. sonar, direction finder
• G06F 18/214 - Generating training patternsBootstrap methods, e.g. bagging or boosting
• G06F 18/25 - Fusion techniques

Abstract

Provides a method for associating a precipitation forecast capability with a teleconnection effect based on coefficients of determination, including following steps: acquiring historical forecast precipitation data, observed precipitation data, and a climate index sample sequence, and obtaining original sample data; establishing regression equations of observed precipitation and forecast precipitation, observed precipitation and a climate index, and observed precipitation and a union set of the forecast precipitation and the climate index, and calculating corresponding coefficients of determination through the regression equations; calculating variances explained by the forecast precipitation alone, by the climate index alone, and by the forecast precipitation and the climate index alone; processing the variances by means of bootstrapping to obtain a reference distribution of the variances; and comparing the original sample data with the reference distribution of the variances to obtain an association result of the precipitation forecast capability and the teleconnection effect.

IPC Classes  ?

• G01W 1/10 - Devices for predicting weather conditions
• G01W 1/14 - Rainfall or precipitation gauges

Abstract

Disclosed is a combination of peptide linkers for protein covalent self-assembly using a spontaneous isopeptide bond, including a peptide linker 1 and a peptide linker 2. The peptide linker 1 contains a peptide chain having an amino acid sequence as shown in SEQ ID NO: 5, and the peptide linker 2 contains any one or more of peptide chains having amino acid sequences as shown in SEQ ID NOs: 11, 13, 14, and 46. The present disclosure constructs a novel protein self-assembly system based on an isopeptide bond, which effectively solves the problem of low binding efficiency of an existing SpyTag/SpyCatcher system, can significantly improve the reaction efficiency of molecules or components fused to a peptide tag and polypeptide thereof, and has a binding efficiency stronger than that of a SpyTag003/SpyCatcher003 system.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

A multiple-views-one-eye display method with sub-pixels as basic display units. The sub-pixels of a display device are taken as basic display units. Through beam-splitting modulation of a grating device, lights from different sub-pixel groups are respectively guided to different viewing zones where a viewer's pupil(s) is located. Different sub-pixel groups project different perspective views of a target scene. Thus with more than one perspective views being received by a same pupil of a viewer, monocular focusable 3D scene display gets implemented. During the display, light beams from sub-pixels of different colors intersect at each display point and overlap to be a colorful spatial light-spot. The light from different colored sub pixels propagates along their respective directions and overlap on each display object point to form spatial colored light points.

IPC Classes  ?

• H04N 13/398 - Synchronisation thereofControl thereof
• G09G 3/00 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes
• H04N 13/156 - Mixing image signals
• H04N 13/32 - Image reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using arrays of controllable light sourcesImage reproducers for viewing without the aid of special glasses, i.e. using autostereoscopic displays using moving apertures or moving light sources
• H04N 13/383 - Image reproducers using viewer tracking for tracking with gaze detection, i.e. detecting the lines of sight of the viewer's eyes

Abstract

The present invention relates to the technical field of cross-media data processing. Disclosed is a joint learning method based on cross-media data. The method comprises the following steps: S1, acquiring cross-media data, and outputting a corresponding plurality of single-modal data token sequences; S2, generating a plurality of single-modal semantic representation features according to the plurality of single-modal data token sequences; S3, generating multi-modal semantic representation features according to the plurality of single-modal data token sequences; S4, directly splicing the plurality of single-modal semantic representation features and the multi-modal semantic representation features, so as to output multi-modal mixed representation matrixes; S5, aggregating the multi-modal mixed representation matrixes, so as to output a final cross-media joint representation feature; S6, establishing a cross-media joint learning model, and training the cross-media joint learning model; and S7, inputting cross-media data to be expressed into the trained cross-media joint learning model, so as to output a cross-media joint expression feature. The present invention can better utilize the difference between cross-media data, and reduce the calculation cost.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

The present invention relates to the technical field of computer vision. Disclosed are a character graph relationship recognition method and system based on cross-media data. The method comprises: acquiring video data and text data; performing shot segmentation processing and key frame extraction on the video data, so as to obtain a video shot segmentation set, and a key frame of each video shot; extracting visual features and facial features from key frames, so as to obtain a scene segmentation set and a video character entity set; fusing the key frame visual features and the scene segmentation set, so as to obtain a story segmentation set, and constructing a character graph based on a video; performing segmentation and character extraction on the text data by using the video shot segmentation set, so as to obtain a text character set; on the basis of the scene segmentation set and the text character set, constructing a character graph based on text; and aggregating the character graph based on the video and the character graph based on the text, so as to obtain a final character graph, and performing analysis and recognizing a character relationship. A final character graph constructed by means of the present invention better conforms to reality, such that a more accurate character relationship can be recognized.

IPC Classes  ?

• G06V 20/40 - ScenesScene-specific elements in video content

Abstract

The invention discloses a method for enhanced denitrification and a device thereof. The device comprises an anoxic tank, an aerobic tank and a carbon source booster connected in sequence, and an output end of the carbon source booster is then connected with the anoxic tank; a plurality of membrane contactors are fixed inside the carbon source booster, the membrane contactor is in a hollow structure, and there is a gap between the membrane contactors and a shell of the carbon source booster. By adopting the device, macromolecular carbon source can be added and hydrolyzed into volatile fatty acids by using the hydrolytic fermentation bacteria existing in the gap between the carbon source booster and the membrane contactors, which then penetrates into the hollow part of the membrane contactors through membrane diffusion, as a small molecular carbon source that can be effectively used by denitrifying bacteria to promote the denitrification process.

IPC Classes  ?

• C02F 3/30 - Aerobic and anaerobic processes
• C02F 101/16 - Nitrogen compounds, e.g. ammonia

Abstract

The present disclosure discloses a novel coronavirus SARS-COV-2 safe replicon system and use thereof in screening an anti-SARS-COV-2 drug. The safe replicon system specifically comprises a nucleic acid sequence encoding a novel coronavirus SARS-COV-2 non-structural protein; and nucleic acid sequences of 5′ UTR and 3′ UTR of a novel coronavirus SARS-COV-2, a transcription regulatory region on which the novel coronavirus SARS-COV-2 non-structural protein can act, and a reporter gene. With the SARS-COV-2 safe replicon system, high-throughput screening of anti-SARS-COV-2 drugs and pharmacologic verification of drugs can be carried out independent of a biosafety level 3 laboratory, and the operation is simple and convenient.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase

Abstract

A method, apparatus and system for performing visible light communication by using a field sequential color liquid crystal display (LCD). A field sequential color LCD having direct-type backlight zones is used as a medium for visible light communication. RGB three-color LEDs in each backlight zone are used as signal sources. The three-color LEDs are turned on simultaneously in one sub-frame. Three high-frequency signals can be respectively modulated and embedded. Each single-color LED forms a single signal source. The communication capacity obtained by the system is three times that when a spatial color mixing LCD is used as a transmitting end. The backlight zones and a receiving end jointly form a multi-input and multi-output (MIMO) visible light communication system. The independent modulation of the RGB three-color LEDs in the backlight zones achieves communication and display integration, and also improves the communication capacity and reliability of the system.

IPC Classes  ?

• H04B 10/116 - Visible light communication

Abstract

The invention belongs to the technical field of biomedical testing, and particularly relates to a biomarker for diagnosis, treatment, and prognosis for hepatocellular carcinoma bone metastasis (HCC) and application thereof. The application of biomarker VAPA for preparing a reagent or a kit for diagnosis, treatment, and prognosis for HCC bone metastasis. The application of the reagent that detects VAPA expression levels in blood and tissues for preparing a reagent or kit for diagnosis, treatment, and prognosis for HCC bone metastasis. Compared with the diagnostic kits in the prior art that can only detect bone metastasis after it has occurred, the VAPA described in this invention offers a more specific and sensitive assay kit for the early prediction, diagnosis, disease progression assessment, treatment efficacy evaluation, drug guidance, and prognosis assessment of HCC bone metastasis. Additionally, the VAPA may also serve as a target for therapeutic interventions in bone metastasis.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present application provides methods and compositions for treating diseases or disorders related to hematopoietic dysfunctions and/or injuries, or for rejuvenating HSPCs.

IPC Classes  ?

• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid

Abstract

The use of induced vesicles in the preparation of a drug for in-vitro blood clotting or in-vitro hemostasis. The induced vesicles are obtained by contacting stem cells or somatic cells with an apoptosis inducing agent. Tissue factor expression is a key factor that induced vesicles achieve in in-vitro blood clotting or in-vitro hemostasis.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61P 7/04 - AntihaemorrhagicsProcoagulantsHaemostatic agentsAntifibrinolytic agents
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• C12N 5/074 - Adult stem cells

Abstract

The present invention belongs to the technical field of photonic integrated chips, and more specifically, relates to a reconfigurable photonic integrated chip based on a phase change material film and a processing method therefor. A phase change material film is processed with femtosecond laser and continuous laser to change its surface phase state distribution; and by customizing the number of pulses, power and the like of the laser for processing, and a pattern shape for processing, a specific surface phase state distribution is achieved, so as to achieve the function of a specific photonic integrated chip.

IPC Classes  ?

• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour

Abstract

Provided in the present invention is a rapid and flexible holomorphic embedding power grid overlimit prediction and stability evaluation method, which comprises: S1, acquiring power grid data, and constructing a voltage stability model of a power system on the basis of a continuous power flow equation; S2, using a rapid and flexible holomorphic embedding thought to solve the voltage stability model so as to determine an continuation interval of a continuous power flow solution at an initial point position; S3, determine whether overlimit occurs in the continuation interval, if yes, updating the continuation interval to obtain a first continuation interval, then converting a node type, updating the voltage stability model and the initial point, determining a continuation interval of a continuous power flow solution at a new initial point position to obtain a second continuation interval, and then executing step S4; and otherwise, directly executing step S4; and S4, determining whether there is an SNB point in the continuation interval, if yes, outputting the SNB point, and performing P-V curve tracking analysis according to the SNB point to output a power grid stability evaluation result; and otherwise, updating the initial point, and skipping to execute step S2.

IPC Classes  ?

• H02J 3/36 - Arrangements for transfer of electric power between ac networks via a high-tension dc link

Abstract

A method for enhancing the broad-spectrum property of a vaccine against COVID-19 mutant strains, and a broad-spectrum COVID-19 vaccine. RBDs of six different COVID-19 mutant strains and six highly conserved CD8+ T cell epitope peptides on the N and S proteins of Sarbecovirus are each subjected to fusion expression, and the six fusion protein antigens are then displayed on the surface of the same nanoparticle to form a Mosaic nanoparticle COVID-19 vaccine. The broad-spectrum COVID-19 vaccine program can overcome the vaccine problem of immune escape caused by severe mutation of COVID-19 mutant strains, which leads to decreased immunogenicity. The designed vaccine immunogen can significantly improve the level of specific antibodies generated by a host against viruses, thereby generating an ability to block the viruses from invading the body, can induce the body to generate humoral and cellular immune responses against various COVID-19 mutant strains, SARS, etc., and has an obvious broad-spectrum property. In addition, the broad-spectrum COVID-19 vaccine can be applied to a variety of vaccination methods, including vaccination via nasal spray, inhalation or injection. Moreover, the vaccine preparation method is simple and purification is easy, and there is a high degree of safety; and the vaccine can be quickly applied to clinical trials.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A dynamic cache-partition isolation system for a multi-core processor, and a control method therefor. The system comprises a multi-core processor, a shared timer interruption module and a shared L2 cache, wherein the shared L2 cache comprises a cache path management unit, a cache control unit, a cache path switching unit and a cache path pool. Dynamic partition management is performed on a cache channel by means of the cache path management unit, the cache control unit and the cache path switching unit, and a dynamic configurable shared L2 cache is provided for the multi-core processor, such that the shared L2 cache can be efficiently used by each core, inter-core cache interference is avoided, the correct running of a processor task is ensured to a certain extent, and the system performance is improved.

IPC Classes  ?

• G06F 15/167 - Interprocessor communication using a common memory, e.g. mailbox

Abstract

Disclosed in the present invention is a fast and flexible holomorphic embedding method and apparatus for economic strategy adjustment. The method includes: obtaining product data and establishing equilibrium polynomial equations based on a Bertrand model; describing the equilibrium polynomial equations as a polynomial system and constructing a polynomial homotopy function; solving the equilibrium polynomial equations to obtain solutions of the equations: and analyzing equilibriums based on the solutions of the equations and performing economic strategy selection. The apparatus includes a memory and a processor configured to perform the fast and flexible holomorphic embedding method for economic strategy adjustment. The present invention can efficiently solve equilibrium polynomial equations based on which an economic strategy can be adjusted, to improve performance of enterprises. The fast and flexible holomorphic embedding method and apparatus for economic strategy adjustment provided by the present invention can be used extensively in the field of strategy adjustment.

IPC Classes  ?

• G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
• G06F 17/11 - Complex mathematical operations for solving equations

Abstract

The present invention provides use of a compound as represented by formula I or a pharmaceutically acceptable salt or ester thereof in the preparation of a drug for treating ASC-caspase-1 pathway-based inflammasome activation-mediated diseases. In particular, the compound of the present invention is preferably lonidamine, and is used for treating gout, multiple sclerosis or septicemia.

IPC Classes  ?

• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/416 - 1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
• A61K 31/415 - 1,2-Diazoles
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• A61P 11/06 - Antiasthmatics
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• A61P 19/06 - Antigout agents, e.g. antihyperuricemic or uricosuric agents
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 37/08 - Antiallergic agents

Abstract

A high-precision underwater moving base alignment method and system based on a magnetic compass and a velocimeter. The method comprises: according to a preset alignment condition, determining whether there is a disturbing acceleration, if not, using an accelerometer and a three-axis magnetometer to perform first-stage coarse alignment to obtain an initial attitude angle (S11); constructing an SRUKF model according to a preset INS/DVL combination alignment algorithm, and performing second-stage coarse alignment according to the initial attitude angle and the SRUKF model to obtain a first attitude angle (S12); and constructing a linear Kalman model according to a preset INS/DVL/DG combination alignment algorithm, and according to the first attitude angle and the linear Kalman model, performing fine alignment by means of an output feedback mode to obtain a second attitude angle (S13). Underwater moving base combination alignment based on a magnetic compass and a velocimeter has high precision, consumes short time, is anti-disturbing, and has a wide range of application, good robustness and high engineering practicability.

IPC Classes  ?

• G01C 21/16 - NavigationNavigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigatedDead reckoning by integrating acceleration or speed, i.e. inertial navigation
• G01C 25/00 - Manufacturing, calibrating, cleaning, or repairing instruments or devices referred to in the other groups of this subclass

Abstract

111 as the value of the complex parameter s, searching the next path until the value of the complex parameter s is converged to 1, and outputting a corresponding power flow solution; otherwise, outputting a warning about a check failure.

IPC Classes  ?

• H02J 3/06 - Controlling transfer of power between connected networksControlling sharing of load between connected networks
• G06F 17/10 - Complex mathematical operations

Abstract

An image watermarking method and device. The method comprises: acquiring an image to be processed, and performing format conversion on said image to obtain pixel format data. The pixel format data comprises luminance component data, blue chrominance component data, and red chrominance component data. The method further comprises: acquiring watermark information, and converting the watermark information into a bit sequence. The method further comprises: modifying luminance component data of each target pixel point in said image on the basis of the value of each bit in the bit sequence to obtain target luminance component data. The target pixel point is used for bearing the value of a corresponding bit in the bit sequence, and the target pixel points are arranged in an array. The method further comprises: combining the target luminance component data with blue chrominance component data and red chrominance component data corresponding to said image to obtain a target image, the target image being an image corresponding to said image and added with the watermark information.

IPC Classes  ?

• H04N 1/387 - Composing, repositioning or otherwise modifying originals
• G06T 1/00 - General purpose image data processing

Abstract

A method and device for auditing data integrity, and a storage medium. The method comprises: slicing, into different file blocks, a file to be uploaded; calculating a file label and a file authenticator corresponding to each file block; sending the file authenticator and the file to a cloud for storage while sending the file label and metadata information to a blockchain; and verifying the integrity of cloud storage data according to the file label and the metadata information in the blockchain. According to the method, a keyless management function is provided, the integrity of cloud data may be audited without possessing a private key of a data owner, and no key information needs to be stored and maintained, which eliminates single-point fault and single-point trust problems introduced by a traditional implementation schemes due to the need for maintaining a centralized key management center, is better suited for a decentralized service scenario, and has low key maintenance costs. In addition, according to the present invention, the transparency of the auditing process may be effectively improved, and the execution efficiency is high.

IPC Classes  ?

• H04L 9/40 - Network security protocols

Abstract

Disclosed in the present application are a point cloud attribute prediction method, and a device and a storage medium. The method comprises: determining a neighbor prediction point of the current prediction point and a first attribute prediction value corresponding to the neighbor prediction point; according to the first attribute prediction value corresponding to the neighbor prediction point, determining a second attribute prediction value corresponding to the current prediction point; and according to the second attribute prediction value, determining a third attribute prediction value corresponding to the current prediction point.

IPC Classes  ?

• H04N 19/124 - Quantisation
• H04N 19/597 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using predictive coding specially adapted for multi-view video sequence encoding

Abstract

kk, and converting a constraint condition of the IP core into a differential constraint formula; using a differential constraint system to generate a control dataflow graph on the basis of the differential constraint formula, and performing resource pre-allocation; scanning, replacing and scheduling operators in the control dataflow graph on the basis of pattern matching and operator motility, and optimizing the control dataflow graph; and performing resource allocation according to the optimized control dataflow graph, so as to generate a hardware circuit structure. By means of the present invention, a specific IP core module can be specified for implementing a function, and an IP core can also be automatically identified and applied during scheduling optimization, thereby effectively improving the development efficiency of a high-level synthesis tool; and the present invention can be widely applied to the field of hardware circuit structure design.

IPC Classes  ?

• G06F 30/343 - Logical level
• G06F 111/04 - Constraint-based CAD

Abstract

The present invention relates to the technical field of image processing. Provided are an image processing method and system based on a high-level synthesis tool. The method comprises the steps of: constructing an image processing flow (S1), wherein the image processing flow comprises image denoising processing based on a Gauss algorithm, edge extraction processing based on a SOBEL algorithm, and feature point extraction processing based on a HARRIS algorithm or a FAST algorithm, which are executed in sequence; using a high-level synthesis tool to optimize the image processing flow by using one or more of loop unrolling processing, data stream processing, pipeline processing and data segmentation processing, so as to generate an image processing (IP) core (S2); and performing C/RTL joint simulation on the IP core in a Vivado HLS tool, and after the IP core passes simulation verification, calling the IP core in an FPGA, so as to complete image processing (S3). In the present invention, an image processing algorithm is designed and optimized by using a high-level synthesis tool, and parallel improvement is performed on the image processing algorithm, thereby improving the image processing speed, and meeting high-speed and high-throughput application requirements. The present invention is particularly suitable for the field of industrial real-time detection.

IPC Classes  ?

• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining

Abstract

The present invention belongs to the technical field of energy conversion materials, and particularly relates to a heater, a preparation method therefor, and an application thereof. The heater comprises, successively stacked, a first insulating layer, a functional layer, and a second insulating layer; the functional layer is a graphene heating film, and the graphene heating film is formed via the screen printing of a water-based graphene conductive slurry containing 0.5-3wt% graphene powder, 0.8-10wt% dispersing agent, and 10-40wt% organic resin, with the remainder being water. The heater of the present invention has advantages such as being light, thin and high strength, low voltage, high efficiency, low energy consumption, of having a long service life, being highly reliable, and having a high degree of integration, and can relatively easily achieve large-area high-curvature conformal heating.

IPC Classes  ?

• H05B 3/20 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater
• H05B 3/02 - Ohmic-resistance heating Details

Abstract

Provided are an epitope peptide (or a variant thereof) that can be used for preventing or treating an EBV infection, a recombinant protein containing the epitope peptide (or variant thereof) and a carrier protein, and the use of the epitope peptide (or variant thereof) and the recombinant protein. Further provided are an antibody against the epitope peptide, and the use thereof in the detection, prevention and/or treatment of an EBV infection and/or diseases caused by the infection.

IPC Classes  ?

• A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus
• A61P 35/00 - Antineoplastic agents
• C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

The present disclosure relates to a technical field of chiral compound synthesis, and particularly to chiral or racemic pyrimidine-fused diazepinone derivatives, preparation method, and application thereof. A structural formula of the chiral or racemic pyrimidine-fused diazepinone derivatives or pharmaceutically acceptable salts thereof is as shown in formula (I), The present disclosure relates to a technical field of chiral compound synthesis, and particularly to chiral or racemic pyrimidine-fused diazepinone derivatives, preparation method, and application thereof. A structural formula of the chiral or racemic pyrimidine-fused diazepinone derivatives or pharmaceutically acceptable salts thereof is as shown in formula (I), The present disclosure relates to a technical field of chiral compound synthesis, and particularly to chiral or racemic pyrimidine-fused diazepinone derivatives, preparation method, and application thereof. A structural formula of the chiral or racemic pyrimidine-fused diazepinone derivatives or pharmaceutically acceptable salts thereof is as shown in formula (I), The present disclosure further provides a preparation method of the chiral or racemic pyrimidine-fused diazepinone derivatives, the method includes using pyrimidine allyl compound intermediates as raw materials, using iridium complexes formed by an interaction between iridium compounds and phosphoramidite ligands as catalysts, and obtaining the chiral or racemic pyrimidine-fused diazepinone derivatives by reactions under action of alkalis. The derivatives have good inhibitory effects on GR, cofilin-1, and NF-κB protein, can reverse apoptosis of PC12 cells caused by corticosterone in a depressed state, and can be applied in the preparation of drugs or their lead compounds for preventing or treating depression.

IPC Classes  ?

• C07D 487/04 - Ortho-condensed systems
• A61P 25/24 - Antidepressants

Abstract

A method for preparing a diester by oxidative carbonylation of an olefin and carbon monoxide, which comprises the following steps: carrying out an oxidative carbonylation reaction on olefin and carbon monoxide in an oxygen-containing atmosphere and in the presence of a catalyst to obtain a 1,4-diester-based compound; the catalyst comprises a procatalyst, a pro-oxidant, an acid, and a dehydrating agent; and the procatalyst is a substance comprising the element Pd; the pro-oxidant comprises one or more among copper salt, iron salt, and iron powder; the acid comprises Lewis acid and/or protonic acid; and the dehydrating agent comprises one or more among a ketal, an acetal, orthoformate, and silicate. The present method has high catalytic efficiency, high selectivity, and a high conversion rate; oxygen or air is used as an oxidizing agent; the catalyst is a green, low-carbon, environment-friendly catalytic system that can be reused, is low-cost, and produces essentially no waste in the production process; and the oxidative carbonylation reaction of the catalyzed olefin and CO prepares the 1,4-diester compound.

IPC Classes  ?

• C07C 67/38 - Preparation of carboxylic acid esters by reaction with carbon monoxide or formates by addition to an unsaturated carbon-to-carbon bond
• C07C 69/40 - Succinic acid esters
• C07C 69/34 - Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
• C07C 69/612 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
• C07C 69/602 - Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
• C07C 69/65 - Halogen-containing esters of unsaturated acids
• C07C 69/608 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
• C07C 69/38 - Malonic acid esters
• C07C 69/44 - Adipic acid esters
• C07C 69/48 - Azelaic acid esters
• C07C 69/63 - Halogen-containing esters of saturated acids

Abstract

Provided in the present invention is a rapid linear programming method for high-level synthesis. The method comprises the following steps: constructing a compression tree library, wherein the compression tree library comprises a plurality of compression trees, and each compression tree is used for describing an input and output and area costs of a hardware circuit; generating an integer linear programming constraint on the basis of the compression tree library, and constructing an integer linear programming model according to the integer linear programming constraint; solving the integer linear programming model, and generating a compression tree network description according to a solving result; and according to the compression tree network description, performing integration to obtain a target hardware circuit description. In the method, by means of cascading and binding general parallel counters, the speed of a circuit after synthesis is improved without sacrificing an area, and a clock frequency is improved, such that rapid linear programming can be realized; and the method can be widely applied to the technical field of circuit simulation.

IPC Classes  ?

• G06F 30/343 - Logical level

Abstract

The present invention provides a high-level synthesis-based lock-in amplification processing method, system and apparatus, and a medium. The method comprises the following steps: determining a target circuit, and obtaining and determining a lock-in amplification function in the target circuit; describing the lock-in amplification function by means of a high-level language to obtain a first function description; verifying the accuracy of the first function description, and according to the verification result, performing high-level synthesis induction on the first function description by means of a low-level language to obtain a second function description; and performing field programmable logic gate array simulation verification according to the second function description, and outputting and obtaining a simulation verification result of the lock-in amplification function. According to the method, a high-level synthesis tool can be controlled to enable same-frequency and frequency-multiplied signals to be in one time step, so as to meet the period accuracy. Moreover, the data bit width and filter configurations of a lock-in amplification algorithm can be quickly changed, lock-in amplification algorithms with different requirements can be quickly generated, so that the development efficiency is further improved, and the method can be widely applied to the technical field of circuit simulation.

IPC Classes  ?

• G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation

Abstract

Provided in the present invention are a graphical high-level synthesis circuit performance analysis method, system and apparatus, and a medium. The method comprises the following steps: acquiring a target circuit demand, and determining a test stimulus program code and a hardware module code according to the target circuit demand; compiling and converting the test stimulus program code to obtain a software description code; compiling and converting the hardware module code to obtain a hardware description code, and performing forward compiling according to the hardware description code to obtain a register conversion-level code; performing decompiling according to the register conversion-level code to obtain a hardware simulation model; performing code instrumentation, and performing simulation compiling on the hardware simulation model which has been subjected to instrumentation, so as to obtain a hardware simulation description code; and performing co-simulation, and visually displaying performance data of a simulation result and a simulation process. The present invention greatly reduces the cost consumption caused by human analysis, improves the high-level synthesis design efficiency according to the characteristics of the simulation model, and can be widely used in the technical field of circuit simulation.

IPC Classes  ?

• G06F 30/3308 - Design verification, e.g. functional simulation or model checking using simulation
• G06F 30/337 - Design optimisation

Abstract

Provided in the present invention is a process layout method for high-level synthesis. The method comprises the following steps: acquiring a circuit description for a target circuit, and performing construction according to the circuit description, so as to obtain a control data flow graph corresponding to the target circuit, wherein the control data flow graph is a directed graph that represents computation operations in the target circuit; partitioning the control data flow graph by means of a plane planning algorithm, so as to obtain layout constraints; scheduling the control data flow graph, and binding a scheduling result, so as to obtain a register transfer level description; and processing the register transfer level description according to the layout constraints, so as to obtain a target netlist, and determining a process layout of the target circuit according to the target netlist. The method reduces the congestion situations during layout wiring by means of high-level synthesis, can also reduce increases in the delay caused by the crossing of the boundary of an FPGA block during the wiring process, and can be widely applied to the technical field of circuit simulation.

IPC Classes  ?

• G06F 30/392 - Floor-planning or layout, e.g. partitioning or placement
• G06F 30/394 - Routing
• G06F 30/398 - Design verification or optimisation, e.g. using design rule check [DRC], layout versus schematics [LVS] or finite element methods [FEM]

Abstract

The present invention belongs to the technical field of biological medicine, and particularly relates to use of sodium formate in the preparation of an anti-infection medicament. According to the present invention, through researches, it is found that sodium formate can significantly improve the sensitivity of bacteria to antibiotics, so that antibiotics that are ineffective or inefficient for pathogenic bacteria become effective or efficient, thereby killing bacteria and achieving the anti-infection effect. Sodium formate and an antibiotic are further prepared into an anti-infection composition. In one aspect, the remarkable anti-infection effect can be achieved under the condition of low-concentration antibiotic; in another aspect, the decrease in the use amount of the antibiotic can also remarkably reduce the possibility that the bacteria develop drug resistance; furthermore, sodium formate is widely used in food and medicines and has high safety.

IPC Classes  ?

• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61P 31/04 - Antibacterial agents

Abstract

The present application belongs to the field of degradable plastics, and particularly relates to a cobalt-based catalyst composition, and a method for preparing a polyester by catalyzing copolymerization of epoxy and carbon monoxide. The cobalt-based catalyst composition provided by the present application comprises a cobalt catalyst and a ligand. The ligand is selected from oxide, sulfide or selenide of bi-phosphine, dinitrogen or nitrogen-phosphine. Compared with a complex catalyst structure used in the prior art, the ligand in the catalytic composition provided by the present application is simple and novel in structure and the catalytic composition is a novel cobalt-based catalyst composition. The yield and the molecular weight of polyhydroxy carboxylate synthesized by catalysis are relatively high, so that the technical problem that a catalytic system of polyhydroxy carboxylate in the prior art is complex is solved.

IPC Classes  ?

• C07F 9/6596 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having atoms other than oxygen, sulfur, selenium, tellurium, nitrogen or phosphorus as ring hetero atoms
• C08G 63/82 - Preparation processes characterised by the catalyst used
• C08G 63/78 - Preparation processes
• C08G 63/00 - Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule

Abstract

The invention relates to a GaN-based trench metal oxide Schottky barrier diode and a preparation method therefor. The device structure from bottom to top includes: an ohmic contact metal layer covering a substrate i.e., cathode; a GaN self-supporting substrate; an n-type lightly doped epitaxial layer; a p-type high-concentration GaN layer arranged in parallel; a dielectric layer in the trench; a metal layer convering the upper surface of the device i.e., the anode. The p-type high-concentration GaN layer with high carrier concentration can be obtained by using a selective area epitaxial method to form the p-type high-concentration GaN layer. Then the dielectric layer is deposited, and a contact hole is provided on the dielectric layer, subsequently the anode metal is connected to the p-type high-concentration GaN layer through the contact hole, forming the ohmic contact.

IPC Classes  ?

• H01L 29/872 - Schottky diodes
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 21/306 - Chemical or electrical treatment, e.g. electrolytic etching
• H01L 21/308 - Chemical or electrical treatment, e.g. electrolytic etching using masks
• H01L 21/285 - Deposition of conductive or insulating materials for electrodes from a gas or vapour, e.g. condensation
• H01L 29/66 - Types of semiconductor device

Abstract

Disclosed are a fusion protein, and a preparation method and use thereof, which belong to the field of biomedicine technologies. The fusion protein comprises a polypeptide specifically bound to a KRas protein, a specific tumor-cell-penetrating peptide and a lysosome recognition peptide. The fusion protein with tumor targeting, penetrability and specific protein degradation is designed and constructed direct to an undruggable protein for the first time, thus providing a new idea for development of an anti-cancer targeted drug. Different from the prior art in which one molecule can only target one target protein, the fusion protein can simultaneously induce degradation of wild-type and mutant-type KRas proteins. Meanwhile, the fusion protein can improve the sensitivity of the KRas mutant-type tumor to the tumor-targeted drug by inducing degradation of KRas, thus expanding an application range of existing anti-cancer targeted drugs and having important significance in tumor clinic treatment.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 38/46 - Hydrolases (3)
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61P 35/00 - Antineoplastic agents
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Abstract

The disclosure provides a light-responsive aptamer for regulating the activity of a DNA polymerase. The DNA polymerase includes a G-quadruplex-binding peptide and a polymerase sequence; the polymerase sequence includes an active site; and the light-responsive aptamer includes an aptamer sequence and a photoactive linker connected to the aptamer sequence; the aptamer sequence includes a G-quadruplex-forming sequence and a substrate DNA sequence; the G-quadruplex-forming sequence forms a G-quadruplex, and the substrate DNA sequence folds to form a hairpin structure; the G-quadruplex-forming sequence binds to the G-quadruplex-binding peptide, and the substrate DNA binds to the active site of the DNA polymerase; in the presence of ultraviolet light irradiation (UV irradiation), the photoactive linker is broken, and the substrate DNA is detached from the active site of the DNA polymerase.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

A precipitation normalization analysis method and system based on gradient parameter optimization. The method comprises the following steps: acquiring precipitation data to be analyzed (S1); constructing a normal transformation model, and performing normal transformation on the precipitation data to obtain a normal variable Z (S2); enabling the normal variable Z to follow a normal distribution, and constructing a joint probability density function of the normal variable Z (S3); constructing a likelihood function for parameter optimization on the basis of the normal transformation model and the joint probability density function (S4); deriving an analytic gradient vector of the likelihood function to optimize the likelihood function until a preset termination condition is met, so as to obtain an optimal parameter which enables the likelihood function to take a maximum value (S5); and updating the normal transformation model on the basis of the optimal parameter, and performing normal transformation and modeling analysis on the precipitation data to obtain a precipitation normalization analysis result (S6).

IPC Classes  ?

• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions

Abstract

Provided are a photoresponsive nucleic acid aptamer, a photoactivable DNA polymerase, a kit, a method for preparing the photoactivable DNA polymerase, a method for activating the photoactivable DNA polymerase, and use of the photoactivable DNA polymerase. The photoresponsive nucleic acid aptamer comprises an aptamer nucleotide sequence and a photocleavable group introduced into the aptamer nucleotide sequence. The photocleavable group is configured for being cleaved upon ultraviolet irradiation to cleave the aptamer nucleotide sequence into two nucleotide sequences. The aptamer nucleotide sequence comprises a G-quadruplex nucleotide sequence capable of forming a G-quadruplex and a side nucleotide sequence capable of forming a hairpin structure. The G-quadruplex nucleotide sequence is configured for binding to a G-quadruplex-binding peptide fused with a DNA polymerase. The side nucleotide sequence is configured for binding to an active site of the DNA polymerase. The use of the photoactivable DNA polymerase provided herein can reduce the difference in amplification time between samples and avoid non-specific amplification, thereby improving the accuracy of nucleic acid detection.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present invention is related to a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.

IPC Classes  ?

• C07K 14/05 - Epstein-Barr virus
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/245 - Herpetoviridae, e.g. herpes simplex virus
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses

Abstract

A directory management method and system for a file system based on Cuckoo hash are provided, including the steps of reading metadata of a sub-directory or a sub-file, used as a target file, in a directory: receiving a request for reading the target file in the directory; for the target file, determining an ith candidate data block, in a hash table of the directory according to a hash calculation result obtained by performing hash calculation on a filename filename of the target file according to an ith hash function of Cuckoo hash iteratively; if the filename filename of the target file exists in the ith candidate data block, reading metadata of the target file and returning the metadata, and ending the process; otherwise, continuing to iterate until the iteration ends and returning a message that the target file does not exist.

IPC Classes  ?

• G06F 16/13 - File access structures, e.g. distributed indices
• G06F 16/11 - File system administration, e.g. details of archiving or snapshots
• G06F 16/14 - Details of searching files based on file metadata

Abstract

Disclosed is an anticancer composition containing auranofin and a mercapto compound and the use thereof. The composition contains auranofin and the mercapto compound. By the combined use of auranofin and the mercapto compound, the problem that auranofin cannot effectively inhibit the proliferation of cancer cells under normal physiological condition is solved. When combined with the mercapto compound, auranofin can inhibit tumor growth well, indicating that the combination of auranofin and the mercapto compound can be used as an anticancer drug composition. Moreover, the uptake of auranofin in tumor tissues also can be adjusted by regulating the type of mercapto compound, and thus, providing better selectivity in vivo anti-cancer.

IPC Classes  ?

• A61K 31/7135 - Compounds containing heavy metals
• A61P 35/00 - Antineoplastic agents
• A61K 31/145 - Amines, e.g. amantadine having sulfur atoms, e.g. thiurams (N—C(S)—S—C(S)—N or N—C(S)—S—S—C(S)—N)Sulfinylamines (—N=SO)Sulfonylamines (—N=SO2)
• A61K 31/10 - SulfidesSulfoxidesSulfones

Abstract

The present application relates to a thermal data determination method, apparatus and device. The method comprises: determining a functional model for Tikhonov regularization, acquiring known conditions for variables in the functional model, executing two or more rounds of regularization parameter selection operation according to the functional model, so as to obtain a preferred solution for a regularization parameter in the last round; according to the preferred solution for the regularization parameter in the last round, determining a finally selected regularization parameter; and determining, according to the finally selected regularization parameter, a final estimated value of a heat flux density distribution in a region to be solved.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

Disclosed are a genome assembly method, a genome assembly apparatus, a device and a storage medium. The method includes: obtaining a gene short sequence, and determining a first segmentation value; segmenting the gene short sequence based on the first segmentation value to obtain each gene subsequence; globally sorting each gene subsequence based on a preset grouped parallel sorting by regular sampling to obtain each sorted gene subsequence; traversing the distributed gene map in parallel to obtain each continuous gene sequence, and filling and assembling each continuous gene sequence to obtain each target continuous gene sequence; and determining a second segmentation value, and in response to that the second segmentation value is greater than or equal to a preset maximum segmentation threshold, assembling each target continuous gene sequence to obtain a genome assembly result.

IPC Classes  ?

• G16B 30/20 - Sequence assembly
• G16B 40/30 - Unsupervised data analysis