Provided are a granulated material and others which can provide novel application methods for absorption promoters. This absorption-promoting granulated material includes a core particle A that contains an absorption promoter and a coating particle layer A that coats the core particle.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
The present invention addresses the problem of improving the moldability of a capsule film material (e.g., a soft capsule film material) containing a vegetable protein so as to impart a new function to a capsule preparation. Examples of the new function include: a function to make the capsule film exhibit various biological activities; a function to achieve a system (DDS; drug delivery system) for delivering an active ingredient of a capsule preparation to the intestines, particularly the large intestine; and a function to enable the use of a highly active drug as a content. As a solution for the problem, a composition for the production of a capsule film is provided, the composition comprising a vegetable-derived protein and at least one component selected from the group consisting of a polyol, a triester and a trialkylamino acid. The composition for the production of a capsule film is subjected to pressure heating treatment to provide a material for the production of a capsule film, and the material for the production of a capsule film can be formed as a capsule for a capsule preparation (preferably a soft capsule preparation).
To provide a soft capsule or the like which is chewable, and in which deformation is suppressed. The soft capsule includes a film, and contents including a first gelling agent, an oil/fat, and an emulsifier.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A24B 15/167 - Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
A24B 15/18 - Treatment of tobacco products or tobacco substitutes
A24B 15/34 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a carbocyclic ring other than a six-membered aromatic ring
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; glue and adhesives for industrial purposes; plant
growth regulating preparations; fertilizers; higher fatty
acids; reagent paper, other than for medical or veterinary
purposes; artificial sweeteners; flour and starch for
industrial purposes. Pharmaceutical preparations and preparations for destroying
vermin; fungicides; herbicides; dietary supplements for
human beings; empty capsules for pharmaceuticals; dietetic
beverages adapted for medical purposes; dietetic foods
adapted for medical purposes; beverages for babies; food for
babies; dietary supplements for animals; reagent paper for
medical purposes; oiled paper for medical purposes; adhesive
tapes for medical purposes; drug delivery agents in the form
of edible wafers for wrapping powdered pharmaceuticals;
gauze for dressings; eyepatches for medical purposes; ear
bandages; menstruation bandages; menstruation tampons;
sanitary napkins; sanitary panties; absorbent cotton;
adhesive plasters; bandages for dressings; liquid bandages;
breast-nursing pads; cotton swabs for medical use; dental
materials; diapers; diaper covers; fly catching paper;
mothproofing paper; lacteal flour for babies; semen for
artificial insemination. Sanitary masks; medical apparatus and instruments. Food processing; providing information in the field of food
manufacturing; food grinding; processing of health foods;
providing information relating to processing of health
foods; processing of raw materials for the manufacture of
food and beverages; processing of foods and dietetic foods
adapted for medical purposes; processing of functional
foods; processing of soft capsules and other pharmaceutical
preparations, for others; custom manufacture and processing
of pharmaceuticals; information and advisory services in the
field of custom manufacture and processing of
pharmaceuticals; processing of pharmaceuticals; information
and advisory services in the field of processing of
pharmaceuticals. Testing, inspection or research of pharmaceuticals,
cosmetics or foodstuffs; computer software design, computer
programming, or maintenance of computer software; providing
computer programs on data networks; quality control of
pharmaceutical preparations; providing information relating
to study and development of pharmaceuticals for others via
the internet; research and development of vaccines and
medicines; development of pharmaceutical preparations for
others; research and development of pharmaceutical
preparations; providing information in the field of research
and development of pharmaceutical preparations; software as
a service (saas).
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; glue and adhesives for industrial purposes; plant growth regulating preparations; fertilizers; higher fatty acids; reagent paper, other than for medical or veterinary purposes; artificial sweeteners; flour and starch for industrial purposes. Pharmaceutical preparations and preparations for destroying vermin; fungicides; herbicides; dietary supplements for human beings; empty capsules for pharmaceuticals; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies; food for babies; dietary supplements for animals; reagent paper for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; gauze for dressings; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton; adhesive plasters; bandages for dressings; liquid bandages; breast-nursing pads; cotton swabs for medical use; dental materials; diapers; diaper covers; fly catching paper; mothproofing paper; lacteal flour for babies; semen for artificial insemination. Food processing; providing information in the field of food manufacturing; food grinding; processing of health foods; providing information relating to processing of health foods; processing of raw materials for the manufacture of food and beverages; processing of foods and dietetic foods adapted for medical purposes; processing of functional foods; processing of soft capsules and other pharmaceutical preparations, for others; custom manufacture and processing of pharmaceuticals; information and advisory services in the field of custom manufacture and processing of pharmaceuticals; processing of pharmaceuticals; information and advisory services in the field of processing of pharmaceuticals. Sanitary masks; medical apparatus and instruments. Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; computer software design, computer programming, or maintenance of computer software; providing computer programs on data networks; quality control of pharmaceutical preparations; providing information relating to study and development of pharmaceuticals for others via the internet; research and development of vaccines and medicines; development of pharmaceutical preparations for others; research and development of pharmaceutical preparations; providing information in the field of research and development of pharmaceutical preparations; software as a service (saas).
7.
SELF-EMULSIFYING COMPOSITION AND PRODUCTION METHOD THEREOF
Provided is a self-emulsifying formulation or the like in a novel form, capable of forming a dosage form such as tablets. A self-emulsifying composition comprising a core particle and a coating particle layer that coats the core particle, the core particle containing a useful substance, an oily component, a surfactant and a thickener.
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
8.
ORAL PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING PARTICULATE FORMULATION COMPRISING COMPOSITION
Provided is an oral pharmaceutical composition characterized by containing a medicinal ingredient (A), a hydrophobic liquid (B), a water-soluble macromolecular substance (C), and an excipient (D), but not containing a surfactant, wherein: the medicinal ingredient (A) is included in the hydrophobic liquid (B); and the hydrophobic liquid (B) is dispersed in a composition including the water-soluble macromolecular substance (C) and the excipient (D). The oral pharmaceutical composition: allows easy dose-adjustment; has excellent dosability and safety; is biologically equivalent to a standard formulation having established profiles regarding efficacy, safety, etc.; and can be easily produced.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/549 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; glue and adhesives for industrial purposes; plant
growth regulating preparations; fertilizers; higher fatty
acids; reagent paper, other than for medical or veterinary
purposes; artificial sweeteners; flour and starch for
industrial purposes. Pharmaceutical preparations and preparations for destroying
vermin, fungicides, herbicides; dietary supplements for
human beings; empty capsules for pharmaceuticals; dietetic
beverages adapted for medical purposes; dietetic foods
adapted for medical purposes; beverages for babies; food for
babies; dietary supplements for animals; reagent paper for
medical purposes; oiled paper for medical purposes; adhesive
tapes for medical purposes; drug delivery agents in the form
of edible wafers for wrapping powdered pharmaceuticals;
gauze for dressings; eyepatches for medical purposes; ear
bandages; menstruation bandages; menstruation tampons;
sanitary napkins; sanitary panties; absorbent cotton;
adhesive plasters; bandages for dressings; liquid bandages;
breast-nursing pads; cotton swabs for medical use; dental
materials; diapers; diaper covers; fly catching paper;
mothproofing paper; lacteal flour for babies; semen for
artificial insemination. Sanitary masks. Food processing; providing information in the field of food
manufacturing; food grinding; processing of health foods;
providing information relating to processing of health
foods; processing of raw materials for the manufacture of
food and beverages; processing of foods and dietetic foods
adapted for medical purposes; processing of functional
foods; processing of soft capsules and other pharmaceutical
preparations, for others; custom manufacture and processing
of pharmaceuticals; information and advisory services in the
field of custom manufacture and processing of
pharmaceuticals; processing of pharmaceuticals; information
and advisory services in the field of processing of
pharmaceuticals. Testing, inspection or research of pharmaceuticals,
cosmetics or foodstuffs; computer software design, computer
programming, or maintenance of computer software; providing
computer programs on data networks; quality control of
pharmaceutical preparations; providing information relating
to study and development of pharmaceuticals for others via
the internet; research and development of vaccines and
medicines; development of pharmaceutical preparations for
others; research and development of pharmaceutical
preparations; providing information in the field of research
and development of pharmaceutical preparations; software as
a service (saas).
Provided is an aroma member of a novel embodiment. The aroma member includes: a capsule-containing substrate that includes a substrate and a breakable capsule that is held by the substrate and that encapsulates a liquid aromatic agent; a first liquid barrier layer that is disposed on one surface of the capsule-containing substrate; and a second liquid barrier layer that is disposed on the other surface of the capsule-containing substrate.
Provided is a novel soft capsule. The soft capsule has a shell comprising gellan gum, wherein the soft capsule satisfies the following requirements: (A) the soft capsule has a disintegration time of 60 minutes or less as measured by a disintegration test method specified in the Japanese Pharmacopoeia using water as a test medium; and/or (B) the soft capsule has a ratio of a crush strength (g) to an outer diameter. (mm) (crush strength/outer diameter ratio) of 210 or more.
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Pharmaceutical preparations and other preparations for
destroying vermin, fungicides, herbicides; dietary
supplements for human beings; empty capsules for
pharmaceuticals; dietetic beverages adapted for medical
purposes; dietetic foods adapted for medical purposes;
beverages for babies; food for babies; dietary supplements
for animals. Food processing; processing of foods and dietetic foods
adapted for medical purposes; processing of soft capsels and
other pharmaceutical preparations, for others; custom
manufacture and preparation of pharmaceuticals; information
and advisory services in the field of custom manufacture and
preparation of pharmaceuticals; processing of
pharmaceuticals; information and advisory services in the
field of processing of pharmaceuticals; processing of
functional foods; providing information in the field of food
manufacturing; processing of health foods; providing
information relating to processing of health foods.
13.
PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME
Provided is a pharmaceutical composition or the like having a new form that can be orally administered even when the contained medicinal effect component is a medicinal effect component such as a high molecular weight component. This pharmaceutical composition includes: a core particle containing a medicinal effect component and an absorption promoting agent; and a coating particle layer that coats the core particle.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Pharmaceutical preparations and other preparations for destroying vermin; fungicides; herbicides; dietary supplements for human beings; capsules sold empty for pharmaceuticals; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies, namely, liquid formula milk for babies; food for babies; dietary supplements for animals Food processing; processing of foods and dietetic foods adapted for medical purposes; processing of soft capsules and other pharmaceutical preparations, for others being custom manufacture of pharmaceuticals; custom manufacture of pharmaceuticals; custom manufacture, namely, preparation of pharmaceuticals; information and advisory services in the field of custom manufacture of pharmaceuticals; information and advisory services in the field of custom manufacture, namely, preparation of pharmaceuticals; processing of pharmaceuticals being custom manufacture of pharmaceuticals; information and advisory services in the field of processing of pharmaceuticals being custom manufacture of pharmaceuticals; processing of functional foods; providing information in the field of food manufacturing; processing of health foods; providing information relating to processing of health foods
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals; glue and adhesives for industrial purposes; plant growth regulating preparations; fertilizers; higher fatty acids; reagent paper, other than for medical or veterinary purposes; artificial sweeteners; flour and starch for industrial purposes. Pharmaceutical preparations and preparations for destroying vermin, fungicides, herbicides; dietary supplements for human beings; empty capsules for pharmaceuticals; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies; food for babies; dietary supplements for animals; reagent paper for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; gauze for dressings; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton; adhesive plasters; bandages for dressings; liquid bandages; breast-nursing pads; cotton swabs for medical use; dental materials; diapers; diaper covers; fly catching paper; mothproofing paper; lacteal flour for babies; semen for artificial insemination. Food processing; providing information in the field of food manufacturing; food grinding; processing of health foods; providing information relating to processing of health foods; processing of raw materials for the manufacture of food and beverages; processing of foods and dietetic foods adapted for medical purposes; processing of functional foods; processing of soft capsules and other pharmaceutical preparations, for others; custom manufacture and processing of pharmaceuticals; information and advisory services in the field of custom manufacture and processing of pharmaceuticals; processing of pharmaceuticals; information and advisory services in the field of processing of pharmaceuticals. Sanitary masks. Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; computer software design, computer programming, or maintenance of computer software; providing computer programs on data networks; quality control of pharmaceutical preparations; providing information relating to study and development of pharmaceuticals for others via the internet; research and development of vaccines and medicines; development of pharmaceutical preparations for others; research and development of pharmaceutical preparations; providing information in the field of research and development of pharmaceutical preparations; software as a service (saas).
16.
COMPOSITION FOR TREATING VASCULAR DISEASE, COMPOSITION FOR REVENTING VASCULAR DISEASE, COMPOSITION FOR TREATING HYPERTENSION, AND COMPOSITION FOR PREVENTING HYPERTENSION
Provided is a composition for the treatment of vascular disease, for the prevention of vascular disease, for the treatment of hypertension or for the prevention of hypertension, comprising caryophyllene.
A composition for treating or preventing respiratory diseases, a composition for improving sleep or promoting sleep onset, a composition for reducing fatigue, a composition for improving complexion, a composition for improving skin texture, a composition for treating or preventing periodontal disease, and a composition for controlling halitosis, each composition containing caryophyllene.
Provided are a novel agent or composition and others.
Provided are a novel agent or composition and others.
The agent or composition comprises caryophyllene and is used for at least one selected from the following (purposes) (1) to (3) :
(1) promoting relaxation, prolonging a resting-state time, and/or prolonging a motionless time,
(2) promoting sleep, and
(3) preventing blood pressure elevation.
Provided are a novel agent or composition and others.
The agent or composition comprises caryophyllene and is used for at least one selected from the following (purposes) (1) to (3) :
(1) promoting relaxation, prolonging a resting-state time, and/or prolonging a motionless time,
(2) promoting sleep, and
(3) preventing blood pressure elevation.
The present invention also relates to a method for inhaling β-caryophyllene simultaneously with smoking a tobacco product, characterized in that the tobacco product contains a β-caryophyllene-containing seamless capsule in a tobacco filter, wherein the seamless capsule contains an essential oil containing β-caryophyllene as an active ingredient. The applicants found that pulmonary inhalation of β-caryophyllene by the above method allows β-caryophyllene to be efficiently distributed throughout the body, leading to achievements of relaxing and sleep-inducing effects, etc.
An object of the present invention is to provide is a novel composition and others. The composition comprises l-menthol and at least one ingredient (X) selected from dicarboxylic acid esters, diol esters, monocarboxylic acid esters, esters of polyols having three or more hydroxy groups, esters of polycarboxylic acids having three or more carboxyl groups, polyol ethers, polyamines, and alcohols having six or more carbon atoms.
A61K 8/33 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
A24D 3/06 - Use of materials for tobacco smoke filters
A24D 3/04 - Tobacco smoke filters characterised by their shape or structure
A24B 15/34 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a carbocyclic ring other than a six-membered aromatic ring
A23L 27/10 - Natural spices, flavouring agents or condimentsExtracts thereof
Provided is a soft capsule to be used in a smokeless tobacco product for oral use, the soft capsule comprising a capsule coating film and a content encapsulated by the capsule coating film, and the soft capsule having breaking hardness of 20 N to 200 N inclusive and a disintegration time of shorter than 5 minutes when measured by the disintegration test method as prescribed in Japanese Pharmacopoeia.
A24B 15/34 - Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a carbocyclic ring other than a six-membered aromatic ring
A24B 13/00 - Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettesChewing tobaccoSnuff
21.
PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME
Provided is a pharmaceutical composition or the like in a new mode and having an enteric coating. This pharmaceutical composition includes: a core particle containing dietary fibers and a medicinal ingredient; and a particle coating layer that covers the core particle.
A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
C07C 13/32 - Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
C07C 13/32 - Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
Provided is a capsule shell composition and the like having excellent handleability. The capsule shell composition comprises a starch, iota carrageenan, and a gum, wherein the content of the carrageenan is 2 mass% or higher with respect to the capsule shell composition, which is taken as 100 mass%, and the content of the gum is 0.3-14 mass% with respect to the capsule shell composition, which is taken as 100 mass%.
Provided are a tablet and a method for producing the tablet, in particular, a technique for tablet production whereby the amount of an active ingredient to be contained in the tablet can be stably regulated without the need of a huge cost for the production. The tablet of the present invention is one obtained by compacting a mixture comprising a granulating composition including a medicinal ingredient or a biofunctional ingredient, and includes a first region, which comprises a binder including the medicinal ingredient or biofunctional ingredient, and a second region, which is adjacent to the first region and comprises the binder including the medicinal ingredient or biofunctional ingredient. The medicinal ingredient or biofunctional ingredient contained in each of the first region and second region is included in the binder, not in the form of a layer but in the state of having been dispersed or dissolved.
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
26.
COMPOSITION FOR TREATING VASCULAR DISEASE, COMPOSITION FOR PREVENTING VASCULAR DISEASE, COMPOSITION FOR TREATING HYPERTENSION, AND COMPOSITION FOR PREVENTING HYPERTENSION
A composition for treating a vascular disease, for preventing a vascular disease, for treating hypertension or for preventing hypertension, which contains caryophyllene.
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
[Problem] The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
[Problem] The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
[Solution] A breakable seamless capsule for a smoking equipment, comprising a content containing an oily ingredient and a capsule shell for encapsulating said content, wherein:
the capsule shell contains a polysaccharide;
the thickness of the capsule shell is 60 μm or more;
the volatilization content (VC) of the content after leaving the content to stand under an environment at a temperature of 25° C. and a relative humidity of 40% for 4 hours is 3.0 wt % or more with respect to the total weight of the encapsulated content; and
the crush strength per diameter of the capsule is 3-8 N/mm. In one embodiment, the crush strength per diameter of the capsule is 3.5-8 N/mm. In another embodiment, the capsule shell does not contain gelatin.
Provided are a novel composition and others. The composition comprises l-menthol and at least one component (X) selected from a dicarboxylic acid ester, a diol ester, a monocarboxylic acid ester, an ester of a polyol having 3 or more hydroxyl groups, an ester of a polycarboxylic acid having 3 or more carboxyl groups, a polyol ether, a polyamine, and an alcohol having 6 or more carbon atoms.
A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
A24B 15/00 - Chemical features or treatment of tobaccoTobacco substitutes, e.g. in liquid form
A24D 3/00 - Tobacco smoke filters, e.g. filter-tips, filtering insertsFilters specially adapted for simulated smoking devicesMouthpieces for cigars or cigarettes
Provided are a novel agent or composition, etc. The agent or composition contains caryophyllene and is used for at least one (purpose) selected from (1)-(3) below. (1) Promotion of a relaxing effect, prolongation of rest time and/or prolongation of quiescent time. (2) Sleep promotion. (3) Suppression of blood pressure elevation. The present invention also pertains to a method for filling a seamless capsule with an essential oil having β-caryophyllene as an active ingredient and mounting the capsule on a cigarette filter, whereby the β-caryophyllene is inhaled simultaneously with smoking. The applicant discovered that by inhaling β-caryophyllene through the lungs by the above method, β-caryophyllene is efficiently distributed throughout the body, leading to a relaxing effect, a sleep-inducing effect, etc.
This is to provide a useful application of plasmalogen, which is not yet known.
This is to provide a useful application of plasmalogen, which is not yet known.
A composition contains plasmalogen for enhancing a verbal memorization ability and/or a visual memorization ability.
A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Provided is a granulation composition that comprises core grains, coating grains and a binder for binding the core grains to each other and also binding the core grains to the coating grains to thereby maintain a granular shape, characterized in that: the coating grains adhere around a main granulation body comprising the core grains and the binder; the coating grains are insoluble in the binder; the core grains and/or the binder contain a medicinal ingredient or a biofunctional ingredient; and the developed interfacial area ratio Sdr is 100-700. According to this granulation composition, a uniform granulated product which is surface-coated with the coating grains and hardly segregated can be stably obtained, even if using a dilute solution with low gel strength as the binder. By setting the gelling agent concentration in the binder at a low level to give a dilute solution, therefore, the granulation composition having excellent properties can be produced at a high productivity.
Provided is a novel soft capsule. This soft capsule has a coating containing gellan gum and satisfies the following (A) and/or (B). (A) The disintegration time of the soft capsule measured in water as a test liquid according to the disintegration test of the Japanese Pharmacopoeia is within 60 minutes. (B) The ratio (breaking strength/outer diameter) of the breaking strength (g) to the outer diameter (mm) is 210 or more.
Provided is a shell composition that is formed with a water-insoluble powder such as starch and/or a water-soluble polymer such as dextrin as a base component, and with locust bean gum and/or xanthan gum as a gelling agent. This shell composition enables a novel shell composition which can favorably form a shell without using carrageenan, has favorable properties that enable the shell composition to substitute traditional shells that use a gelatin shell or carrageenan, and comprises a plant-derived base.
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A23L 29/219 - Chemically modified starchReaction or complexation products of starch with other chemicals
A23L 29/238 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
A23L 29/269 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
A23P 10/30 - Encapsulation of particles, e.g. foodstuff additives
35.
Seamless capsule, filter and smoking equipment containing same
The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
the crush strength per diameter of the capsule is 3-8 N/mm.
Provided are a tablet and a method for producing the tablet, in particular, a technique for tablet production whereby the amount of an active ingredient to be contained in the tablet can be stably regulated without the need of a huge cost for the production. The tablet of the present invention is one obtained by compacting a mixture comprising a granulating composition including a medicinal ingredient or a biofunctional ingredient, and includes a first region, which comprises a binder including the medicinal ingredient or biofunctional ingredient, and a second region, which is adjacent to the first region and comprises the binder including the medicinal ingredient or biofunctional ingredient. The medicinal ingredient or biofunctional ingredient contained in each of the first region and second region is included in the binder, not in the form of a layer but in the state of having been dispersed or dissolved.
[Problem] To provide a capsule capable of disintegrating and capable of suppressing volatilization over time from a capsule film for highly-volatile capsule content. [Solution] A seamless capsule that is used in a smoking device and is capable of disintegrating, wherein the seamless capsule comprises content including an oily component, and a capsule film for encapsulating the content. The capsule film contains polysaccharides and has a thickness of at least 60 μm. The volatile content (VC) of the content at four hours when left to stand in an environment in which the temperature is 25°C and the relative humidity is 40% is 3.0% by weight relative to the total weight of the content that has been blended in. The breaking strength per capsule diameter is 3–8 N/mm. In an embodiment, the breaking strength per capsule diameter is 3.5–8 N/mm. In another embodiment, the capsule film does not include gelatin.
Provided is a capsule capable of disintegrating and capable of suppressing volatilization over time from a capsule film for highly-volatile capsule content. A seamless capsule that is used in a smoking device and is capable of disintegrating, wherein the seamless capsule comprises content including an oily component, and a capsule film for encapsulating the content. The capsule film contains polysaccharides and has a thickness of at least 60 μm. The volatile content (VC) of the content at four hours when left to stand in an environment in which the temperature is 25°C and the relative humidity is 40% is 3.0% by weight relative to the total weight of the content that has been blended. The breaking strength per capsule diameter is 3–8 N/mm.
Provided is a useful but not publicly known application of plasmalogen. This plasmalogen-containing composition is for increasing a verbal memorization ability and/or a visual memorization ability.
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 35/655 - Aquatic animals other than those covered by groups
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Provided is a granulation composition that comprises core grains, coating grains and a binder for binding the core grains to each other and also binding the core grains to the coating grains to thereby maintain a granular shape, characterized in that: the coating grains adhere around a main granulation body comprising the core grains and the binder; the coating grains are insoluble in the binder; the core grains and/or the binder contain a medicinal ingredient or a biofunctional ingredient; and the developed interfacial area ratio Sdr is 100-700. According to this granulation composition, a uniform granulated product which is surface-coated with the coating grains and hardly segregated can be stably obtained, even if using a dilute solution with low gel strength as the binder. By setting the gelling agent concentration in the binder at a low level to give a dilute solution, therefore, the granulation composition having excellent properties can be produced at a high productivity.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Provided is a coating composition that is characterized by comprising a water-insoluble powder such as starch and/or a water-soluble polymer such as dextrin as a base component, and locust bean gum and/or xanthan gum as a gelling agent. This coating composition enables a novel coating composition to be obtained which can favorably form a coating without using carrageenan, has favorable properties that enable the coating composition to substitute traditional coatings that use a gelatin coating or carrageenan, and comprises a plant-derived base.
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
A23L 29/238 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of vegetable origin from seeds, e.g. locust bean gum or guar gum
A23L 29/269 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A capsule excellent in enteric property with the assumption that gelatin is used as a main base material of the capsule coating. An alkali-treated gelatin and carrageenan are contained as base materials of the capsule coating. In the gastric (aqueous) environment, the alkali-treated gelatin which is positively (+) charged coexists with the carrageenan which is negatively (−) charged, and amino groups (NH4+) in the gelatin react with sulfate groups (SO3−) in the carrageenan so that the capsule coating is insolubilized. On the other hand, in the intestinal (aqueous) environment, the alkali-treated gelatin which is negatively (−) charged coexists with the carrageenan which is negatively (−) charged, and the amino groups (NH4+) in the gelatin are repulsive to the sulfate groups (SO3−) in the carrageenan so that the capsule coating quickly disintegrates and dissolves.
Provided is an oral pharmaceutical composition characterized by containing a medicinal ingredient (A), a hydrophobic liquid (B), a water-soluble macromolecular substance (C), and an excipient (D), but not containing a surfactant, wherein: the medicinal ingredient (A) is included in the hydrophobic liquid (B); and the hydrophobic liquid (B) is dispersed in a composition including the water-soluble macromolecular substance (C) and the excipient (D). The oral pharmaceutical composition: allows easy dose adjustment; has excellent dosability and safety; is biologically equivalent to a standard formulation having established profiles regarding efficacy, safety, etc.; and can be easily produced.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
By assuming the use of gelatin as a main base material of a capsule coating, provided is a capsule having excellent enteric properties. The enteric capsule contains alkali-treated gelatin and carrageenan as base materials of a capsule coating. In the gastric (aqueous) environment, the alkali-treated gelatin that is positively (+) charged coexists with the carrageenan that is negatively (-) charged and amino (NH4+) group in the gelatin reacts with sulfate (SO3-) group in the carrageenan so that the capsule coating is insolubilized. Meanwhile, in the enteric (aqueous) environment, the alkali-treated gelatin that is negatively (-) charged coexists with the carrageenan that is also negatively (-) charged and amino (NH4+) group in the gelatin repulses with sulfate (SO3-) group in the carrageenan so that the capsule coating quickly disintegrates and dissolves.
wherein (Y) represents distance/outer diameter ratio, where the distance represents the distance (mm) that is deformed to reach the maximum load, when the capsule is ruptured over the press under the condition of 22° C., 80% RH.
The purpose of the present invention is to provide a collapsible capsule for which: the capsules do not adhere to each other; the capsule contents do not change over time; the capsule has excellent heat resistance and moisture resistance; the capsule can be broken easily when finger pressure is applied; and the capsule has a satisfying feel when broken and is able to release the contents. The present invention relates to a collapsible capsule with contents and a capsule film, the capsule being characterized in comprising oil components for the contents, comprising at least a film-forming base for the capsule film and satisfying formula (1) and formula (2). 200 < (X) < 560 (1) (in the formula, (X) represents the rupture strength (g)/outer capsule diameter (mm)) 0.20 ≤ (Y) ≤ 0.48 (2) (in the formula, (Y) represents the ratio of distance/outer diameter, said distance representing the distance (mm) to which the capsule deforms by the time maximum load is reached when the capsule is ruptured by applying a press on the capsule at 22°C and 80% RH.
The objective of the present invention is to provide a disintegrable capsule, groups of which do not adhere to each other, the contents of which does not change over time, which is heat resistant and moisture resistant, which can be easily broken by applying pressure with the fingers, which provides a pleasant sensation when broken, and the contents of which can be released. This disintegrable capsule has contents and a capsule coating film, and is characterized by including an oil component as the contents, and at least a film-forming base as the capsule coating film, and by satisfying formula (1) and formula (2). (1) 150<(X)<630 (In the formula, (X) represents breaking strength (g)/outer diameter (mm) of capsule.) (2) 0.15≤(Y)≤0.53 (In the formula, (Y) represents the distance/outer diameter ratio, where said distance represents the distance (mm) by which the capsule is deformed until the maximum load is reached when the capsule is pressed at 22℃ and 80% RH, and broken.)
