Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61L 29/14 - Materials characterised by their function or physical properties
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
Embodiments herein relate to forming active agent releasing depots in situ for maintaining patency of lesions over extended terms. A method herein of forming an active agent releasing depot in situ for maintaining patency of lesions over extended terms can include contacting a composition with a vessel wall. The composition includes an active agent and a fibrin promoting vessel wall transfer agent, wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method can include transferring the composition from a device surface to the vessel wall surface and forming an initial fibrin matrix around the composition. The transferred composition can be effective to maintain patency of targeted lesions over a period at least 6 months. Other embodiments are also included herein.
A61K 38/36 - Blood coagulation or fibrinolysis factors
A61K 31/453 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A thrombectomy system includes an inner catheter, an outer catheter, an adjustable basket, and at least one debulking element. The outer catheter defines an outer catheter lumen. The inner catheter is slidably received within the outer catheter lumen such that the inner catheter is slidable relative to the outer catheter. The adjustable basket has a fenestrated structure extending between a proximal collar and a distal collar. The proximal collar is attached to a distal end of the outer catheter and the distal collar is attached to a distal end of the inner catheter. The at least one debulking element is positioned on the outer catheter proximal to the adjustable basket. The fenestrated structure is radially expanded by sliding the inner catheter in a first direction relative to the outer catheter and is radially collapsed by sliding the inner catheter in a second direction opposite the first direction.
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/138 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord combined with cutting implements
A thrombectomy system includes an inner catheter, an outer catheter, an adjustable basket, and at least one debulking element. The outer catheter defines an outer catheter lumen. The inner catheter is slidably received within the outer catheter lumen such that the inner catheter is slidable relative to the outer catheter. The adjustable basket has a fenestrated structure extending between a proximal collar and a distal collar. The proximal collar is attached to a distal end of the outer catheter and the distal collar is attached to a distal end of the inner catheter. The at least one debulking element is positioned on the outer catheter proximal to the adjustable basket. The fenestrated structure is radially expanded by sliding the inner catheter in a first direction relative to the outer catheter and is radially collapsed by sliding the inner catheter in a second direction opposite the first direction.
A thrombectomy guidewire system includes a thrombectomy guidewire having a wire shaft with a proximal portion and a distal portion, the wire shaft is sized for receiving and delivering guidewire deliverable intravascular thrombectomy devices. The thrombectomy guidewire includes a self-expanding basket positioned at the distal portion of the wire shaft and configured to self-expand from a collapsed configuration to an expanded configuration. A exchange sheath includes a first lumen configured to slidably receive the wire shaft and a second lumen aligned with the central lumen. The exchange sheath is slidable in a distal direction over the wire shaft from the proximal portion of the wire shaft at least until the self-expanding basket is sheathed within the central lumen and collapsed into the collapsed configuration.
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A thrombectomy guidewire system includes a thrombectomy guidewire having a wire shaft with a proximal portion and a distal portion, the wire shaft is sized for receiving and delivering guidewire deliverable intravascular thrombectomy devices. The thrombectomy guidewire includes a self-expanding basket positioned at the distal portion of the wire shaft and configured to self-expand from a collapsed configuration to an expanded configuration. A exchange sheath includes a first lumen configured to slidably receive the wire shaft and a second lumen aligned with the central lumen. The exchange sheath is slidable in a distal direction over the wire shaft from the proximal portion of the wire shaft at least until the self-expanding basket is sheathed within the central lumen and collapsed into the collapsed configuration.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
7.
LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES
Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
Embodiments herein relate to biofouling resistant coatings for medical devices. In an embodiment, an anti-fouling coated medical device is included having a substrate and a coating disposed over the substrate. The coating can include a hydrogel, and a polyzwitterion. The polyzwitterion can include a bound portion and an unbound portion. In some embodiments the coating can further include a heparin compound. Other embodiments are also included herein.
A61L 33/00 - Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of bloodMaterials for such treatment
Embodiments herein relate to lubricious coatings for medical devices. A coated medical device is included having a substrate and a lubricious coating disposed thereon. In some embodiments, the lubricious coating can include an outer protective layer including long polymer chains. The long polymer chains can include a bonded end and a mobile free end. In some embodiments, the lubricious coating can include a hydrogel layer and long polymer chains that are at least partially disposed within the lubricious coating. Other embodiments are also included herein.
Embodiments herein relate to polyacrylic acid containing lubricious coatings for medical devices. In an embodiment, a lubricious coated medical device is included having a substrate and a first layer disposed over the substrate. The first layer can include a photoreactive polyvinylpyrrolidone, a non-photoreactive polyvinylpyrrolidone, and a crosslinking compound. A second layer can be disposed over the first layer, the second layer can include a poly(acrylic acid), and a non-photoreactive polyvinylpyrrolidone. The non-photoreactive polyvinylpyrrolidone of the second layer forms a complex with the poly(acrylic acid) of the second layer. The non-photoreactive polyvinylpyrrolidone of the second layer has a concentration existing as a gradient through a thickness of the second layer with a lower concentration at an outer surface of the second layer than at an inner surface of the second layer. Other embodiments are also included herein.
C10M 107/28 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to a carboxyl radical, e.g. acrylate
Embodiments herein relate to lubricious coatings for medical devices. A coated medical device is included having a substrate and a lubricious coating disposed thereon. In some embodiments, the lubricious coating can include an outer protective layer including long polymer chains. The long polymer chains can include a bonded end and a mobile free end. In some embodiments, the lubricious coating can include a hydrogel layer and long polymer chains that are at least partially disposed within the lubricious coating. Other embodiments are also included herein.
Embodiments herein relate to polyacrylic acid containing lubricious coatings for medical devices. In an embodiment, a lubricious coated medical device is included having a substrate and a first layer disposed over the substrate. The first layer can include a photoreactive polyvinylpyrrolidone, a non-photoreactive polyvinylpyrrolidone, and a crosslinking compound. A second layer can be disposed over the first layer, the second layer can include a poly(acrylic acid), and a non-photoreactive polyvinylpyrrolidone. The non-photoreactive polyvinylpyrrolidone of the second layer forms a complex with the poly(acrylic acid) of the second layer. The non-photoreactive polyvinylpyrrolidone of the second layer has a concentration existing as a gradient through a thickness of the second layer with a lower concentration at an outer surface of the second layer than at an inner surface of the second layer. Other embodiments are also included herein.
Embodiments herein relate to medical devices and coatings for the same. In an embodiment, a drug delivery coating can be included having a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The drug delivery coating can also include an active agent layer disposed over the polymeric layer. The active agent layer can include a microcrystalline active agent and a cationic agent. Other embodiments are also included herein.
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61L 29/14 - Materials characterised by their function or physical properties
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
Embodiments herein relate to medical devices and coatings for the same. In an embodiment, a drug delivery coating can be included having a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The drug delivery coating can also include an active agent layer disposed over the polymeric layer. The active agent layer can include a microcrystalline active agent and a cationic agent. Other embodiments are also included herein.
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61L 29/14 - Materials characterised by their function or physical properties
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
Medical device, namely, mechanical thrombectomy device and a catheter deployed system for thrombectomy procedures; medical device, namely, a catheter deployed system with deployable filters and trumpet for capturing and macerating emboli; Thrombectomy devices, and parts therefor
Embodiments herein relate to a system for coating rotatable medical devices and related methods. In an embodiment, a coating system for coating rotatable medical devices is included. The coating system can include a rotation mechanism, wherein the rotation mechanism is configured to mount and rotate a rotatable medical device. The coating system can also include a fluid applicator unit. The fluid applicator unit can include a rotating retention sleeve, the rotating retention sleeve defining a channel, wherein the rotatable medical device fits within the channel. The fluid applicator unit can also include a retention sleeve drive mechanism, wherein the retention sleeve drive mechanism is configured to rotate the rotating retention sleeve. The coating system can also include an inner collar, wherein the inner collar fits within the channel of the rotating retention sleeve. Other embodiments are also included herein.
Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.
Systems, devices and methods for treating a stenosed vessel or heart valve are disclosed. In some embodiments, a cutting/scoring assembly/device for treating a stenosed vessel/heart valve is provided and includes a main, elongated scoring sleeve or element with multiple longitude wires arranged at a distal end. A distal end of the elongated element is proximal to the multiple longitude wires which, when used in conjunction with a balloon catheter, is used to for, according to some embodiments, localized controlled longitudinal vessel incision.
A lubricious coating for a medical device is formed including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.
B05D 7/00 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
C10M 107/28 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to a carboxyl radical, e.g. acrylate
C10M 107/42 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
C10M 107/46 - Lubricating compositions characterised by the base-material being a macromolecular compound containing sulfur
C10M 107/48 - Lubricating compositions characterised by the base-material being a macromolecular compound containing phosphorus
C10M 107/50 - Lubricating compositions characterised by the base-material being a macromolecular compound containing silicon
C10M 135/36 - Heterocyclic sulfur, selenium or tellurium compounds the ring containing sulfur and carbon with nitrogen or oxygen
C10M 169/04 - Mixtures of base-materials and additives
C10M 177/00 - Special methods of preparation of lubricating compositionsChemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes
C10N 20/00 - Specified physical properties of component of lubricating compositions
C10N 50/00 - Form in which the lubricant is applied to the material being lubricated
Aspects herein relate to coating apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a valve, a fluid supply reservoir in fluid communication with the valve, a reciprocating positive displacement pump in fluid communication with the valve, and a fluid applicator in fluid communication with the three-way valve. The valve can be configured to assume a first fluid transport state and a second fluid transport state, wherein the valve provides fluid communication between the fluid supply reservoir and the reciprocating positive displacement pump when in the first fluid transport state for filling of the reciprocating positive displacement pump, and wherein the valve provides fluid communication between the reciprocating positive displacement pump and the fluid applicator when in the second fluid transport state for applying a coating suspension to a medical device surface. Other embodiments are also included herein.
B05C 11/08 - Spreading liquid or other fluent material by manipulating the work, e.g. tilting
B05C 1/08 - Apparatus in which liquid or other fluent material is applied to the surface of the work by contact with a member carrying the liquid or other fluent material, e.g. a porous member loaded with a liquid to be applied as a coating for applying liquid or other fluent material to work of indefinite length using a roller
29.
Lubricious medical device coating with low particulates
Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.
Medical devices, namely, catheters, guide sheaths, guide
sheath extensions, guidewires, guidewire extensions,
guidewire management devices, catheter deployable devices,
namely, scoring devices and stents, devices for placing and
securing catheters, re-entry devices for re-entering the
vessel if a guidewire or catheter exits the vessel, and
radial access accessories, namely, wire splints and
hemostasis devices for accessing a radial artery.
In an example, a scoring device is configured for retention of a catheter shaft. The scoring device incudes a proximal portion and a distal portion. A retention sleeve extends between the proximal and distal portions. The retention sleeve has a catheter socket configured to selectively receive and mechanically engage the catheter shaft. The scoring device includes a scoring tool coupled with the retention sleeve, for instance proximate to the distal portion. The scoring tool includes a balloon socket configured to selectively receive a balloon of the catheter shaft. The scoring tool includes one or more scoring elements extending around the balloon socket, the one or more scoring elements configured to provide localized scoring to vasculature.
In an example, a catheter assembly includes a catheter body extending from a catheter proximal portion to a catheter distal portion having a distal tip. a coil proximate to the catheter distal portion, the coil having a first section and a second section, wherein the first section has a first imaging characteristic. The second section is swaged, and the second section of the coil has a second imaging characteristic. The second imaging characteristic differs from the first imaging characteristic, and the different first and second imaging characteristics are configured to contrast and emphasize visibility of the distal tip relative to the remainder of the catheter body. In another example, a second braided layer of the catheter body is configured to constrain and brace a first braided layer.
An anchored dilator includes a push tube having proximal and distal push tube portions. A dilator tip is coupled with the distal push tube portion and is configured for selectable coupling with a catheter. The dilator tip includes an anchor cuff having a cuff interface. The anchor cuff is configured to transition between a shuttle configuration having a shuttle profile and an anchored configuration having an anchored profile larger than the shuttle profile. A cuff operator assembly is configured to transition the anchor cuff between the anchored and shuttle configurations. The cuff operator assembly includes a cuff operator movably coupled with the dilator tip, and an operator shaft coupled with the cuff operator. The operator shaft extends toward the proximal push tube portion. Actuation of the cuff operator with the operator shaft transitions the anchor cuff between the shuttle configuration and the anchored configuration.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
In an example, a scoring device is configured for retention of a catheter shaft. The scoring device incudes a proximal portion and a distal portion. A retention sleeve extends between the proximal and distal portions. The retention sleeve has a catheter socket configured to selectively receive and mechanically engage the catheter shaft. The scoring device includes a scoring tool coupled with the retention sleeve, for instance proximate to the distal portion. The scoring tool includes a balloon socket configured to selectively receive a balloon of the catheter shaft. The scoring tool includes one or more scoring elements extending around the balloon socket, the one or more scoring elements configured to provide localized scoring to vasculature.
An anchored dilator includes a push tube having proximal and distal push tube portions. A dilator tip is coupled with the distal push tube portion and is configured for selectable coupling with a catheter. The dilator tip includes an anchor cuff having a cuff interface. The anchor cuff is configured to transition between a shuttle configuration having a shuttle profile and an anchored configuration having an anchored profile larger than the shuttle profile. A cuff operator assembly is configured to transition the anchor cuff between the anchored and shuttle configurations. The cuff operator assembly includes a cuff operator movably coupled with the dilator tip, and an operator shaft coupled with the cuff operator. The operator shaft extends toward the proximal push tube portion. Actuation of the cuff operator with the operator shaft transitions the anchor cuff between the shuttle configuration and the anchored configuration.
Medical device, namely, mechanical thrombectomy device and a
catheter deployed system composed of deployable medical
filters and trumpet for capturing emboli for thrombectomy
procedures; medical device, namely, catheter deployed system
composed of deployable medical filters and trumpet for
capturing emboli.
Embodiments herein relate to active agent depots formed in situ and related methods. In various embodiments, a method of forming an active agent depot in situ is included. The method can include contacting a composition with a vessel wall, wherein the composition includes an active agent and a fibrin promoting vessel wall transfer agent wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method also includes transferring the composition from a device surface to the vessel wall surface. The method also includes forming a fibrin matrix around the composition. Other embodiments are also included herein.
Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.
The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.
A catheter assembly includes a catheter shaft having shaft proximal and distal portions. A hub is coupled with the catheter shaft proximate the shaft proximal portion. A graduated strain relief fitting is coupled between the catheter shaft and the hub. The graduated strain relief fitting includes at least a first flexural modulus proximate the hub and a fitting proximal portion. The graduated strain relief fitting includes a second flexural modulus proximate the catheter shaft and a fitting distal portion. The second flexural modulus is less than the first flexural modulus and less than or equal to a catheter shaft flexural modulus. The first and second flexural moduli are modulated with one or more of a taper, flexure joints, fitting frame of the fitting or material of the fitting body.
Aspects herein relate to apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a two-part fluid applicator defining a central channel, the two-part fluid applicator can include a first part having a first degree of flexibility; and a second part having a second degree of flexibility. The system can further include a fluid supply conduit in fluid communication with the fluid applicator; and a fluid supply reservoir in fluid communication with the fluid supply conduit. Other embodiments are also included herein.
A61L 31/00 - Materials for other surgical articles
B05C 21/00 - Accessories or implements for use in connection with applying liquids or other fluent materials to surfaces, not provided for in groups
B05C 5/02 - Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work from an outlet device in contact, or almost in contact, with the work
Medical devices, namely, catheters, guide sheaths in the nature of a medical device for placing catheters and other medical devices within the blood vessel, guide sheath extensions, guidewires, guidewire extensions, guidewire management devices in the nature of devices for controlling movement of guidewires during medical procedures, catheter deployable devices, namely, scoring devices in the nature of catheter deployed devices for disrupting blood clots and stents, devices for placing and securing catheters, re-entry devices for re-entering the blood vessel if a guidewire or catheter exits the blood vessel, and radial access accessories, namely, wire splints and hemostasis devices for accessing a radial artery
Medical device, namely, mechanical thrombectomy device and a catheter deployed system composed of deployable medical filters and trumpet for capturing emboli for thrombectomy procedures; medical device, namely, catheter deployed system composed of deployable medical filters and trumpet for capturing emboli
01 - Chemical and biological materials for industrial, scientific and agricultural use
02 - Paints, varnishes, lacquers
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
Reagents for scientific or medical research use;
photoreactive chemical coating compositions for industrial,
including medical, use; chemicals for use in the manufacture
of medical device coatings; chemical preparations for
scientific purposes used for blocking and antibody dilution
in blotting applications; chemical preparations for
scientific purposes for use with analytical procedures in
research and diagnostic applications; liquid preparation for
use in stabilizing reagents employed in immunoassays;
chemical solutions for stabilizing biological molecules for
scientific or medical research use and for use in the
manufacture of medical devices; chemicals, namely, a
chemical solution for use in preserving analytical reagents
for scientific and research use; photoreactive chemical
coating compositions for general industrial use, and for use
in the manufacture of medical devices and diagnostic test
devices; diagnostic assay kits composed primarily of DNA
assay substrates and reagents; diagnostic assay components,
namely, DNA assay substrates and reagents; chemicals for use
in the manufacture of coatings for medical devices;
chemicals for use in the manufacture of drug eluting
coatings; chemicals for use in the manufacture of drug
delivery coatings; biopolymer based coatings for use in the
manufacture of implantable medical devices, namely, coatings
containing extracellular matrix proteins designed to improve
and accelerate tissue healing of implantable medical
devices; chemical coatings used in the manufacture of
medical devices. Medical device coatings; coatings for biological and
surgical implants, for providing a lubricious and
biocompatible surface, sold separately from the implants;
chemical coatings for medical devices, for delivery of a
wide range of pharmaceuticals, sold separately from the
medical devices; medical device coatings for coronary,
peripheral, neurovascular or heart devices; lubricious
coatings for medical devices; hemocompatible coatings for
medical devices. Chemical preparations for medical purposes, namely, for
coating medical devices and delivering medicine for the
treatment of vascular disease; drug delivery matrices
consisting of compounds that facilitate delivery of a wide
range of pharmaceuticals; chemical reagents for medical or
veterinary purposes. Microarray slides for scientific, laboratory or medical
research use; polymer coated beads, membranes, plates and
surfaces that immobilize or attach target biomolecules to
the surface while preventing absorption of unwanted
biomolecules to the surface, for laboratory or scientific
use. Medical devices and apparatus, namely, catheters and drug
eluting balloon catheters; medical devices, namely, stents
that contain and deliver a wide range of pharmaceuticals;
orthopedic implants, ocular implants and surgical implants
comprised of artificial materials, coated with material for
the delivery of a wide range of pharmaceuticals; medical
stents and other implantable medical devices, coated with
material containing extracellular matrix proteins designed
to improve and accelerate tissue healing of implantable
medical devices; medical devices, namely, coronary stent
systems; medical devices, namely, angioplasty catheters;
medical devices, namely, medical device access systems;
medical devices, namely, chronic total occlusion devices;
medical devices, namely, embolic protection device; medical
devices, namely, hemostasis introducer sheath; medical
devices, namely, interventional micro-catheter. Surface treatment services for stabilizing proteins upon
enzyme immunoassay product components of others; consulting
about custom manufacturing medical and surgical devices;
consulting in the field of medical devices related to
manufacturing coaxial guide catheters.
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
A61L 29/14 - Materials characterised by their function or physical properties
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A hemodialysis vascular access device includes a proximal end sized and shaped to sealably couple to a hemodialysis catheter, a movable structure coupled to the proximal end, a fixation structure coupled to the movable region and sized and shaped for fixation on a patient, an elongated sleeve coupled to the fixation structure and sized and shaped for insertion into a patient's vasculature, and a valve at a distal end of the internal lumen. When a hemodialysis catheter is inserted into the device and coupled to the proximal end, distal movement of the proximal end relative to the fixation structure biases a distal end of the hemodialysis catheter from a position inside the elongated sleeve through a valve out of the device and into the patient's blood.
Embodiments of the invention include apparatus and methods for coating drug coated medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit. The coating application unit can include a fluid applicator having a lengthwise axis and a width. The fluid applicator can include a tip comprising a first face across the width of the fluid applicator. The first face of the fluid applicator can be oriented at an angle of from about 15 to about 75 degrees with respect to the lengthwise axis of the fluid applicator. The fluid applicator can define a second face intersecting the first face. The coating apparatus can further include a rotation mechanism and an axial motion mechanism. Other embodiments are also included herein.
B05B 13/04 - Means for supporting workArrangement or mounting of spray headsAdaptation or arrangement of means for feeding work the spray heads being moved during operation
Embodiments of the invention include apparatus and methods for coating drug coated medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit. The coating application unit can include a fluid applicator having a lengthwise axis and a width. The fluid applicator can include a tip comprising a first face across the width of the fluid applicator. The first face of the fluid applicator can be oriented at an angle of from about 15 to about 75 degrees with respect to the lengthwise axis of the fluid applicator. The fluid applicator can define a second face intersecting the first face. The coating apparatus can further include a rotation mechanism and an axial motion mechanism. Other embodiments are also included herein.
The disclosure provides plaque treatment catheter assemblies for the treatment of arterial plaques and removal of clots. One assembly includes a second catheter tube movable within a first catheter tube, and an expansion member movable within the second tube. The second catheter tube has one or more distally-disposed and outwardly-expandable plaque treatment portion(s). Another assembly includes a catheter tube and at least one channel(s) within the catheter. The channel includes an elongate member with a distally-disposed plaque scoring or clot retrieval member. Optionally, the assembly includes an expandable member that can cause movement of the scoring member.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.
01 - Chemical and biological materials for industrial, scientific and agricultural use
02 - Paints, varnishes, lacquers
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
(1) Antibody reagents for scientific purposes, diagnostic reagents for medical-scientific research use, and cell culture reagents for scientific or research purposes; photoreactive chemical coating compositions for industrial, including medical, use; chemical additives and chemical preparations for use in the manufacture of medical device coatings; chemical reagents for scientific purposes used for blocking and antibody dilution in blotting applications; chemical preparations for use with analytical procedures in research and diagnostic preparations, namely, for use in immunoblotting / western blotting, ELlSA (enzyme-linked immunosorbant assay), EIA (enzyme immuno assay), ELiSPOT (enzyme linked immunosorbent spot), immunohistochemistry, radioimmunoassays, rapid/lateral flow assays, microarrays, microfluidics, multiplexing instruments and flow cytometry; chemical preparations for use in stabilizing reagents employed in immunoassays; chemical solutions for stabilizing biological molecules for scientific or medical research use and for use in the manufacture of medical devices; chemicals, namely, a chemical solution for use in preserving analytical reagents for scientific and research use; photoreactive chemical coating compositions for general industrial use, and for use in the manufacture of medical devices and diagnostic test devices; diagnostic assay kits composed primarily of DNA assay substrates and reagents; diagnostic assay components, namely, DNA assay substrates and reagents; chemical additives and chemical preparations for use in the manufacture of coatings for medical devices; chemical reagents and chemical preparations for use in the manufacture of drug eluting coatings; chemical additives and chemical preparations for use in the manufacture of drug delivery coatings; biopolymer based coatings for use in the manufacture of implantable medical devices, namely, coatings containing extracellular matrix proteins designed to improve and accelerate tissue healing of implantable medical devices; chemical coatings used in the manufacture of medical devices.
(2) Coatings for biological and surgical implants, for providing a lubricious and biocompatible surface, sold separately from the implants; chemical coatings for coronary, peripheral, neurovascular or heart devices, for the delivery of pharmaceutical preparations for the treatment of vascular disease, sold separately from the medical devices; medical device coatings for coronary, peripheral, neurovascular or heart devices; lubricious coatings for medical devices; hemocompatible coatings for medical devices.
(3) Chemical preparations for facilitating delivery of pharmaceutical preparations for the treatment of vascular disease; drug delivery matrices consisting of chemical preparations for facilitating the delivery of pharmaceuticals from the surface of a medical implant or medical device; diagnostic chemical reagents for medical and veterinary purposes.
(4) Microarray slides for scientific, laboratory or medical research use; polymer coated beads, membranes, plates and surfaces that immobilize or attach target biomolecules to the surface while preventing absorption of unwanted biomolecules to the surface, for laboratory or scientific use.
(5) Medical devices and apparatus, namely, catheters and drug eluting balloon catheters; medical devices, namely, stents that contain and deliver pharmaceutical preparations for the treatment of vascular disease; orthopedic implants, ocular implants and surgical implants comprised of artificial materials, coated with material for the delivery of pharmaceutical preparations for the treatment of vascular disease, ocular disorders and diseases, Urologic diseases, and diabetes; medical stents and other implantable medical devices, coated with material containing extracellular matrix proteins designed to improve and accelerate tissue healing of implantable medical devices; medical devices, namely, coronary stent systems; medical devices, namely, angioplasty catheters; vascular access ports, catheters, guide sheaths, and hemostasis valves for medical purposes; medical devices, namely, chronic total occlusion devices; medical devices, namely, embolic protection device; medical devices, namely, hemostasis introducer sheath; medical devices, namely, interventional micro-catheter. (1) Chemical treatment services for stabilizing proteins on enzyme immunoassay product component surfaces of others so that proteins can more accurately react with the target analyte; consulting about custom manufacturing of medical and surgical devices, namely, catheters and drug eluting balloon catheters, stents that contain and deliver pharmaceutical preparations for the treatment of vascular disease, orthopedic implants, ocular implants and surgical implants comprised of artificial materials, coated with material for the delivery of pharmaceutical preparations for the treatment of vascular disease, medical stents and other implantable medical devices, coated with material containing extracellular matrix proteins designed to improve and accelerate tissue healing of implantable medical devices, coronary stent systems, angioplasty catheters, chronic total occlusion devices, embolic protection device, hemostasis introducer sheath, interventional micro-catheter; consulting in the field of medical devices related to manufacturing coaxial guide catheters.
Systems, devices and methods for treating a stenosed vessel or heart valve are disclosed. In some embodiments, a cutting/scoring assembly/device for treating a stenosed vessel/heart valve is provided and includes a main, elongated element (e.g., wires) with multiple longitude wires arranged at a distal end. A distal end of the elongated element is proximal to the multiple longitude wires which, when used in conjunction with a balloon catheter, is used to for, according to some embodiments, localized controlled longitudinal vessel incision.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/221 - Calculus gripping devices in the form of loops or baskets
2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
Medical device, namely, mechanical thrombectomy device and a
catheter deployed system for thrombectomy procedures;
medical device, namely, a catheter deployed system with
deployable filters and trumpet for capturing and destroying
emboli.
57.
Method and apparatus for coating balloon catheters
A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
B05B 13/02 - Means for supporting workArrangement or mounting of spray headsAdaptation or arrangement of means for feeding work
B05D 1/00 - Processes for applying liquids or other fluent materials
B05C 13/00 - Means for manipulating or holding work, e.g. for separate articles
B05D 3/12 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by mechanical means
58.
CATHETERS WITH STRUCTURALLY SUPPORTED EXPANDABLE ELEMENTS AND METHODS FOR SAME
A balloon catheter includes a catheter shaft extending between proximal and distal end portions along a shaft axis. The catheter shaft includes an inflation lumen, and at least one inflation port in communication with the inflation lumen. A balloon assembly is coupled with the catheter shaft and in communication with the at least one inflation port. The balloon assembly includes a balloon membrane having a balloon body, a balloon proximal nose and a balloon distal nose coupled with the catheter shaft. An interlaced jacket is coupled with the balloon membrane, the interlaced jacket includes interlaced filaments extending at diverging angles relative to the shaft axis.
Embodiments herein include high-pressure balloon catheters and methods for making the same. In an embodiment, a balloon catheter is included. The balloon catheter can include a catheter shaft and a balloon disposed on the catheter shaft. The balloon can include a wall member including an extruded material layer, a fibrous layer disposed to the outside of the extruded material layer, and at least one of a polyurethane composition and an epoxy composition contacting the fibrous layer. Other embodiments are also included herein.
A balloon catheter includes a catheter shaft extending between proximal and distal end portions along a shaft axis. The catheter shaft includes an inflation lumen, and at least one inflation port in communication with the inflation lumen. A balloon assembly is coupled with the catheter shaft and in communication with the at least one inflation port. The balloon assembly includes a balloon membrane having a balloon body, a balloon proximal nose and a balloon distal nose coupled with the catheter shaft. An interlaced jacket is coupled with the balloon membrane, the interlaced jacket includes interlaced filaments extending at diverging angles relative to the shaft axis.
Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.
C10M 107/26 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to an acyloxy radical of a saturated carboxylic or carbonic acid
C10M 107/46 - Lubricating compositions characterised by the base-material being a macromolecular compound containing sulfur
C10M 107/42 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.
C07C 275/38 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
C07C 271/28 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
65.
Article coatings including oligomerized polyphenol layer and biological methods of use
Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Medical device coatings; Coatings for biological and surgical implants, for providing a lubricious and biocompatible surface, sold separately from the implants; Coatings for medical devices, for delivery of a wide range of pharmaceuticals, sold separately from the medical devices; Chemical coatings used in the manufacture of medical devices; Medical device coatings for coronary, peripheral, neurovascular or heart devices; lubricious coatings for medical devices; Hemocompatible Coatings for medical devices Chemical preparations for medical purposes, namely, for coating medical devices and delivering medicine for the treatment of vascular disease; Drug delivery matrices consisting of compounds that facilitate delivery of a wide range of pharmaceuticals; cell and tissue delivery matrices consisting of compounds that facilitate delivery of cells and tissue to the body; naturally biodegradable matrix used as a carrier for pharmaceuticals, cells and tissue; Chemical reagents for medical or veterinary purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Reagents for scientific or medical research use; Photoreactive chemical coating compositions for industrial, including medical, use; Chemicals for use in the manufacture of medical device coatings; Chemical preparations for scientific purposes used for blocking and antibody dilution in blotting applications; chemical preparations for scientific purposes for use with analytical procedures in research and diagnostic applications; Liquid preparation for use in stabilizing reagents employed in immunoassays; Chemical solutions for stabilizing biological molecules for scientific or medical research use and for use in the manufacture of medical devices; Chemicals, namely, a chemical solution for use in preserving analytical reagents for scientific and research use; photoreactive chemical coating compositions for general industrial use, and for use in the manufacture of medical devices and diagnostic test devices; Diagnostic assay kits composed primarily of DNA assay substrates and reagents; diagnostic assay components, namely, DNA assay substrates and reagents; Chemicals for use in the manufacture of coatings for medical devices; chemicals for use in the manufacture of drug eluting coatings; chemicals for use in the manufacture of drug delivery coatings; Biopolymer based coatings for use in the manufacture of implantable medical devices, namely, coatings containing extracellular matrix proteins designed to improve and accelerate tissue healing of implantable medical devices Microarray slides for scientific, laboratory or medical research use; beads, membranes, plates and surfaces for scientific research use; customizable polymer surfaces that immobilize or attach target biomolecules to the surface while preventing adsorption of unwanted biomolecules to the surface, sold as an integral component of all the aforesaid goods Medical devices and apparatus, namely, catheters and drug eluting balloon catheters; Medical devices, namely, stents that contain and deliver a wide range of pharmaceuticals; coatings for orthopedic implants, ocular implants and surgical implants comprised of artificial materials, sold as an integral part of the implants, for the delivery of a wide range of pharmaceuticals; Coatings sold as an integral component of medical stents and other implantable medical devices, namely, coatings containing extracellular matrix proteins designed to improve and accelerate tissue healing of implantable medical devices; Medical devices, namely, coronary stent systems; Medical devices, namely, angioplasty catheters; Medical devices, namely, medical device Access systems; Medical devices, namely, chronic total occlusion devices; Medical devices, namely, embolic protection device; Medical devices, namely, hemostasis introducer sheath; Medical devices, namely, interventional micro-catheter Surface treatment services for stabilizing proteins upon enzyme immunoassay product components of others; consulting about custom manufacturing medical and surgical devices; consulting in the field of medical devices related to manufacturing coaxial guide catheters Research and development services in the field of chemical analysis tests and procedures; Research and development of new products for others in the fields of pharmaceuticals and medical and surgical devices; scientific and research consultation and product research in the fields of pharmaceuticals and medical and surgical devices; product development consultation in the fields of pharmaceuticals and medical and surgical devices; scientific and research consulting in the field of medical devices and medical device coatings and medical device drug delivery systems; scientific and research consulting in the fields of conducting medical pre-clinical studies and clinical trials; consulting in the field of quality control for medical devices and testing for quality control; Custom design of medical device coatings for others; Testing services for medical devices and medical device coatings; medical device testing for Durability, Shelf-life, aging studies process reproducibility, coating morphology consistency, Defect analysis, impurities, contaminants, drug release mechanisms; diagnostic services in the field of medical devices and coatings; Consulting in the field of medical devices related to design and development of coaxial guide catheter
Medical devices, namely, radial guide sheaths and guide catheters for facilitating passage of smaller diameter catheters, catheter guide wires, and endovascular devices into and/or through blood vessels; medical guidewires, medical guide sheaths, medical guide catheters, devices for placing and securing catheters
Medical devices, namely, radial guide sheaths and guide catheters for facilitating passage of smaller diameter catheters, catheter guide wires, and endovascular devices into and/or through blood vessels; medical guidewires, medical guide sheaths, medical guide catheters, devices for placing and securing catheters
Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
B05B 13/04 - Means for supporting workArrangement or mounting of spray headsAdaptation or arrangement of means for feeding work the spray heads being moved during operation
Medical device, namely, mechanical thrombectomy device and a catheter deployed system composed of deployable medical filters and trumpet for capturing emboli for thrombectomy procedures; medical device, namely, catheter deployed system composed of deployable medical filters and trumpet for capturing emboli
The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.
A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 9/00 - Medicinal preparations characterised by special physical form
2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, a drug delivery coating is included herein having a base polymeric layer, the base polymeric layer including a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The drug delivery coating can further include a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer including a particulate hydrophobic therapeutic agent and a cationic agent. Other embodiments are also included herein.
Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.
Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, a drug delivery coating is included herein having a base polymeric layer, the base polymeric layer including a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The drug delivery coating can further include a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer including a particulate hydrophobic therapeutic agent and a cationic agent. Other embodiments are also included herein.
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
85.
Hydrophobic active agent particle coatings and methods for treatment
Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.
Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Chemical preparations for medical purposes, namely, for
coating medical devices and delivering medicine for the
treatment of vascular disease. Medical devices and apparatus, namely, catheters and drug
eluting balloon catheters.
The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
A61L 29/14 - Materials characterised by their function or physical properties
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A balloon system includes a balloon catheter extending from a proximal end portion to a distal end portion. The balloon catheter includes an inflation lumen therein. A balloon assembly is coupled with the distal end portion of the balloon catheter. The balloon assembly includes a balloon having distal and proximal balloon ends, has inflated and folded deflated configurations. One or more deflation guides are coupled with the balloon. The one or more deflation guides are configured to bias the balloon toward the folded deflated configuration.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61F 2/844 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body, and that can provide advantages in terms of balloon insertion, safety, and drug delivery. The insertion tool includes a tubular portion that accommodates a balloon portion of a balloon catheter, and one or more separation margin(s) in the wall of the tubular portion or one or more split(s) in the tubular wall. The insertion tool also includes a proximal tab that extends from a second lengthwise half having a portion at an angle skew to the lengthwise axis, or that is in the form of a solid article comprising a concave surface that is fastened to an outer surface of the second lengthwise half of the tubular portion; or first and second tabs that extend from first and second lengthwise halves of the tubular portion, respectively.
The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body, and that can provide advantages in terms of balloon insertion, safety, and drug delivery. The insertion tool includes a tubular portion that accommodates a balloon portion of a balloon catheter, and one or more separation margin(s) in the wall of the tubular portion or one or more split(s) in the tubular wall. The insertion tool also includes a proximal tab that extends from a second lengthwise half having a portion at an angle skew to the lengthwise axis, or that is in the form of a solid article comprising a concave surface that is fastened to an outer surface of the second lengthwise half of the tubular portion; or first and second tabs that extend from first and second lengthwise halves of the tubular portion, respectively.
Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
B05B 13/04 - Means for supporting workArrangement or mounting of spray headsAdaptation or arrangement of means for feeding work the spray heads being moved during operation
The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.
Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.
Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.
