The invention concerns a method for determining cancer in a subject, said method comprising performing Raman spectral analysis of a biological sample obtained from the subject and, optionally, comparing a portion of the spectrum from the sample with that of a control; use of the afore method to determine likelihood of cancer, in particular breast, pancreatic, lung and/or colorectal cancer; use of said method to further select a course of treatment for cancer, and a method of treatment comprising same; and a kit of parts for use in said method.
The invention relates to a method for determining the existence and severity of prostate cancer in a human subject comprising detecting the amount of one or more extracellular vesicle (EV) marker(s) provided in a patient sample; a method for monitoring the progression of prostate cancer in a human subject comprising undertaking, then repeating, the method of the invention; a method for selecting a course of prostate cancer treatment comprising performing the method of the invention and then determining a suitable or selected course of treatment; a method for treating prostate cancer using the method of the invention; and a kit of parts comprising at least one detecting agent that detects at least one of the extracellular vesicle (EV) marker(s) provided in a patient sample.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Computer software for database management, namely research
database management computer software; computer software,
namely, an application for collecting and analysing research
data; computer software used for the secured transmission of
research data via a global network; computer software for
providing data analysis; computer software for use in
analysing and generating reports on research data; all of
the aforesaid specifically excluding products and services
relating to perimeter fencing and perimeter security whether
physical or electronic relating specifically to perimeter
and fencing security products. Database development services in the field of scientific and
academic research; research services relating to computers;
software as a service (SaaS) services featuring software in
the field of controlled access service which maintains
databases of research information and provides access to
such information to research institutions; providing
temporary use of on-line non-downloadable software for
scientific and academic research and trends and profiling
for use in the field of research; providing temporary use of
non-downloadable research database management software for
use in evaluating academic and scientific research;
computerized data storage services; all of the aforesaid
specifically excluding products and services relating to
perimeter fencing and perimeter security whether physical or
electronic relating specifically to perimeter and fencing
security products. The provision of medical and healthcare information and
advisory services provided electronically; medical and
healthcare information retrieval services.
A nanoparticle for encapsulation of one or more active pharmaceutical ingredient, said nanoparticle comprising an amphiphilic block copolymer, wherein said amphiphilic block copolymer comprises: i. a hydrophobic polymer block comprising structural units of trimethylene carbonate; and ii. a hydrophilic polymer block comprising structural units of one or more alkylene glycols. A drug delivery vector comprising one or more active pharmaceutical ingredients encapsulated within said nanoparticle. A process for preparing said nanoparticle, the process comprising: i. dissolving said amphiphilic block copolymer in an oligomeric alkylene glycol solution to prepare an alkylene glycol-polymer solution; and ii. hydrating said alkylene glycol-polymer solution by addition of water, an aqueous solution or an aqueous buffer to prepare said nanoparticle. A process for preparing said drug delivery vector by encapsulating one or more active pharmaceutical ingredients within a nanoparticle, wherein said process comprises: i. co-dissolving said amphiphilic block copolymer and said one or more active pharmaceutical ingredients in an oligomeric alkylene glycol solution to prepare an alkylene glycol-polymer solution; and ii. hydrating said alkylene glycol-polymer solution by the addition of water, an aqueous solution or an aqueous buffer to prepare said drug delivery vector. Said drug delivery vector for use as a medicament, preferably for use in the treatment of cancer.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
The invention concerns a conductive anticorrosion coating composition for application onto a metallic substrate, and methods for preparing such coated metallic substrates The invention also extends to the use of such compositions for coating a metal substrate to provide a conductive anticorrosion layer, and to articles comprising a metal component and a conductive anticorrosion coating layer bound thereto.
The disclosed technology includes a filter including a substrate at least partially coated with a sorbent material, the sorbent material including a basic copper sulphate such as brochantite. Also disclosed is a filter including a substrate at least partially coated with a metal-containing sorbent material, wherein the sorbent material includes nanowires having a width of less than 50 nm. Also disclosed is a method for manufacturing a filter, the method including drawing a sorbent material through a substrate by applying a pressure differential across the substrate.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The invention concerns a sampling device for performing analysis of a sample in a manner that safeguards against contamination or infection; a reader for use in combination with said sampling device; a method for performing analysis of a sample involving the use of said device and reader; and a kit of parts comprising at least one, and ideally a plurality of the said, sampling devices and its associated reader and, optionally a wand swab.
The invention relates to methods for separating particles in a microfluidic device and, ideally, encapsulating said particles in at least one or a stream of droplets; and a kit of parts for performing said methods.
The invention relates to a carbon ink composition for use in printing a conductive carbon layer onto a perovskite solar device stack. Also provided is a perovskite solar device stack comprising a conductive carbon layer, and a method of manufacturing such a device by a solution processing method.
H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
H10K 71/60 - Forming conductive regions or layers, e.g. electrodes
H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
The invention relates to an ink composition for printing conductive tracks with high electrical conductivity for electronic applications, and which can be recycled to recover the conductive particles via an environmentally friendly extraction process for re-use, without further processing, in a further conductive ink composition. Also provided are substrates comprising a printed current track formed from such compositions; substrates comprising a surface mount electronic component adhered to said substrate via contact with an adhesive composition formed from such ink compositions; and substrates comprising a conductive coating formed from such ink compositions for use in, e.g., induction sealing and/or to provide an antimicrobial coating. Methods of forming such printed tracks, coated substrates and/or adhering surface mount components to a substrate are also provided.
The invention relates to a method for the production of single alpha chain collagens and an isolated or purified product comprising single alpha chain collagens.
The invention concerns a nanocomposite material for use as a high surface area heterogenous or electrocatalyst, and methods for preparing such catalysts.
The invention concerns a catalyst for the low energy manufacture of ammonia; a process for manufacturing said catalyst; and a process for low energy manufacture of ammonia comprising the use of said catalyst.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Downloadable electronic data in the fields of healthcare,
health data and health management; computer software for use
in healthcare database management; computer software, namely
an application for collecting and analysing health
information; computer software used for the secured
transmission of health care data via a global network;
computer software for providing data analysis; computer
software for use in analysing and generating reports on
health data. Database development services in the field of health care;
computer services, namely, providing analysis of computer
databases in the field of health care [terms too vague in
the opinion of the International Bureau - Rule 13 [2] [b] of
the Common Regulations]; software as a service (SaaS)
services featuring software in the field of controlled
access service which maintains databases of patient health
information and provides access to such information to
health care personnel and health care institutions;
providing temporary use of on-line non-downloadable software
for health care and trends and profiling for use in the
field of preventative health; providing temporary use of
non-downloadable health database management software for use
in evaluating a person or population's health status;
research and consulting services for others in the field of
health care data analysis [terms too vague in the opinion of
the International Bureau - Rule 13 [2] [b] of the Common
Regulations]. The provision of medical and healthcare information and
advisory services provided electronically; medical and
healthcare information retrieval services.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Computer software for database management, namely research database management computer software; computer software, namely, an application for collecting and analysing research data; computer software used for the secured transmission of research data via a global network; computer software for providing data analysis; computer software for use in analysing and generating reports on research data; all of the aforesaid specifically excluding products and services relating to perimeter fencing and perimeter security whether physical or electronic relating specifically to perimeter and fencing security products. (1) Database development services in the field of scientific and academic research; research services relating to computers; software as a service (SaaS) services featuring software in the field of controlled access service which maintains databases of research information and provides access to such information to research institutions; providing temporary use of on-line non-downloadable software for scientific and academic research and trends and profiling for use in the field of research; providing temporary use of non-downloadable research database management software for use in evaluating academic and scientific research; computerized data storage services; all of the aforesaid specifically excluding products and services relating to perimeter fencing and perimeter security whether physical or electronic relating specifically to perimeter and fencing security products.
(2) The provision of medical and healthcare information and advisory services provided electronically; medical and healthcare information retrieval services.
The invention relates to an antibody, or an antigen binding fragment thereof, that selectively binds Receptor for Advanced Glycation Products (RAGE) and, 5 ideally, provides for cell internalisation whereby said antibody can act as an antibody-drug-conjugate (ADC); a polynucleotide and/or vector encoding the said antibody; a cell transformed with said polynucleotide and/or said vector; a pharmaceutical composition comprising said antibody; an ADC comprising said antibody; and the use of said antibody, said ADC or said pharmaceutical 10 composition in the treatment of or prevention of a disorder characterised by elevated RAGE expression, such as cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A transparent conductive electrode (100) for optoelectronic applications has a substrate layer (102), a transparent conducting layer (104) comprising a transparent electrically conductive material and a patterned conducting structure (106) constructed from a metal or semi-metal material having an electrical conductivity at least one order of magnitude greater than the transparent conducting material. The conducting structure is at least partially embedded in at least one of the substrate layer and the transparent conducting layer such that the in-plane electrical resistance properties of the transparent conductive electrode is decoupled from its out-of-plane resistance properties.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
(1) Downloadable electronic data in the fields of healthcare, health data and health management; computer software for use in healthcare database management; computer software, namely an application for collecting and analysing health information; computer software used for the secured transmission of health care data via a global network; computer software for providing data analysis; computer software for use in analysing and generating reports on health data. (1) Database development services in the field of health care; computer services, namely, providing analysis of computer databases in the field of health care [terms too vague in the opinion of the International Bureau - Rule 13 [2] [b] of the Common Regulations]; software as a service (SaaS) services featuring software in the field of controlled access service which maintains databases of patient health information and provides access to such information to health care personnel and health care institutions; providing temporary use of on-line non-downloadable software for health care and trends and profiling for use in the field of preventative health; providing temporary use of non-downloadable health database management software for use in evaluating a person or population's health status; research and consulting services for others in the field of health care data analysis [terms too vague in the opinion of the International Bureau - Rule 13 [2] [b] of the Common Regulations].
(2) The provision of medical and healthcare information and advisory services provided electronically; medical and healthcare information retrieval services.
The invention relates to a device for electro spraying or electro spinning wherein said device comprises a chamber for housing a fluid to be electro spun or electro sprayed, characterized in that, said chamber also includes at least one electrically conducting member situated in and/or about said fluid in said chamber or at least one movable electrically conducting member that can be positioned at least partially in said fluid in said chamber when the fluid is to be charged; further the invention also relates to a dispensing device adapted to accommodate said device and a method of electro spraying or electro spinning using said device or said dispenser.
A data processing system comprising a shared model (204) from a federated learning system and a generative model (101), wherein the system is configured to receive authentic gradient data (208) from local datasets of the federated learning system, using the generative model, generate synthetic data (108) and synthetic labels (114) for the synthetic data, using the shared model, generate synthetic gradient data (306) based the synthetic data and synthetic labels, and optimise the generative model by minimising the difference between the authentic gradient data and the synthetic gradient data, wherein the system is further configured to receive authentic data from the federated learning model, generate synthetic data using authentic gradient data according to the optimised generative model, and measure the similarity between the synthetic data generated according to the optimised generative model and the authentic data.
The invention relates to methods for separating particles in a microfluidic device and, ideally, encapsulating said particles in at least one or a stream of droplets; and a kit of parts for performing said methods.
A polymeric film includes a substrate at least partially coated with hydrophobic particles, the hydrophobic particles include: a metal oxide core; and a hydrocarbon chain having from 2 to 40 carbon atoms, wherein the hydrocarbon chain is chemically bound to the metal oxide core
In, or for use in, a strength test apparatus, an intermediate part wherein the intermediate part includes a recess for accommodate at least one force transducer or sensing element that is configured to measure a force in a first direction; a strength test apparatus including said intermediate part and a strength test method involving use of said apparatus and said part.
G01L 1/22 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress using resistance strain gauges
24.
WEARABLE APPARATUS FOR SENSING STRESS AND METHOD OF USE THEREOF
King Abdullah University of Science and Technology (Saudi Arabia)
Swansea University (United Kingdom)
Inventor
Duarte, Carlos M.
Wilson, Rory
Abstract
Wearable devices that track activity and ventilation rates for use on humans or animals that breathe air and methods of use thereof, are provided. The device is generally suitable to be worn around a subject's chest, and typically contains one or more sensors. Generally, one sensor detects respiratory rate and another sensor detects acceleration (i.e. activity). The method and apparatus can be used to determine the minimum ventilation rate for a given degree (intensity) of movement to construct the ‘stress-free’ relationship between ventilation rate and movement. Then measured values of ventilation rate in relation to movement are compared to the predicted, minimum ventilation rates (stress-free values) and the minimum ‘stress-free’ values are subtracted from the measured values. The difference (Ventilation Rate Above Predicted’ (VRAP)) correlates with stress in the subject.
The invention concerns a process for the manufacture of a biosensor; a biosensor manufactured according to said process; and method for taking a biological measurement comprising the use of said biosensor.
A polymeric film includes a substrate at least partially coated with hydrophobic particles, the hydrophobic particles include: a metal oxide core; and a hydrocarbon chain having from 2 to 40 carbon atoms, wherein the hydrocarbon chain is chemically bound to the metal oxide core
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
C09D 7/62 - Additives non-macromolecular inorganic modified by treatment with other compounds
C08K 9/04 - Ingredients treated with organic substances
A polymeric film includes a substrate at least partially coated with hydrophobic particles, the hydrophobic particles include: a metal oxide core: and a hydrocarbon chain having from 2 to 40 carbon atoms, wherein the hydrocarbon chain is chemically bound to the metal oxide core.
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
The invention concerns a self-supporting hook for attaching to a planar structure that has spaced proximal and distal aligned surfaces and a hole provided in at least said proximal surface for receiving the hook wherein the hook has a hanging member and a supporting member connected theretogether by a connecting member whose size is commensurate with, or related to,the distance between said surfaces; a method of attaching said hook to said structure; a planar structure comprising at least one, and typically a plurality, of said self-supporting hook(s) anchored therein; and a kit of parts comprising a plurality of different sized and/or shaped self-supporting hook(s).
The present invention provided a vertical GaN power FET having a source terminal in contact with the gate-side n+GaN region and the pGaN region. The present invention also provides a method of manufacture of such a device.
H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/417 - Electrodes characterised by their shape, relative sizes or dispositions carrying the current to be rectified, amplified or switched
H01L 21/336 - Field-effect transistors with an insulated gate
30.
WEARABLE APPARATUS FOR SENSING STRESS AND METHOD OF USE THEREOF
KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (Saudi Arabia)
SWANSEA UNIVERSITY (United Kingdom)
Inventor
Duarte, Carlos M.
Wilson, Rory
Abstract
Wearable devices that track activity and ventilation rates for use on humans or animals that breathe air and methods of use thereof, are provided. The device is generally suitable to be worn around a subject's chest, and typically contains one or more sensors. Generally, one sensor detects respiratory rate and another sensor detects acceleration (i.e. activity). The method and apparatus can be used to determine the minimum ventilation rate for a given degree (intensity) of movement to construct the 'stress-free' relationship between ventilation rate and movement. Then measured values of ventilation rate in relation to movement are compared to the predicted, minimum ventilation rates (stress-free values) and the minimum 'stress-free' values are subtracted from the measured values. The difference (Ventilation Rate Above Predicted' (VRAP)) correlates with stress in the subject.
The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.
The invention concerns a process for the manufacture of a biosensor; a biosensor manufactured according to said process; and method for taking a biological measurement comprising the use of said biosensor.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12N 11/10 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
The invention concerns a dual function patch for delivering an agent into an individual and sensing an analyte typically associated with the delivery of, or effect of, said agent; and a method of delivering an agent into the skin and sensing an analyte typically associated with the delivery of, or effect of, said agent using said patch.
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
The invention concerns a method of making a synthetic, biodegradable, bone graft comprising a three-dimensional porous structure; a formulation of constituents for use in said method; a synthetic, biodegradable bone graft produced by said method; and a method of surgery comprising use of said bone graft.
Some variations of the invention provide a bioink composition for 3D bioprinting, comprising: nanocellulose in the form of nanocellulose crystals, nanocellulose fibrils, or preferably a combination thereof; alginate that is ionically crosslinkable in the presence of an ionic crosslinking agent; and water. The nanocellulose-alginate bioinks have favorable rheological, swelling, and biocompatibility properties for extrusion-based bioprinting. It is experimentally demonstrated that nanocellulose-alginate bioinks with human nasoseptal chondrocytes enable cartilage bioprinting at high resolution. The disclosed nanocellulose has been proven to be compatible with cell survival and proliferation; to possess nanoscale and microscale architectures mimicking the native extracellular environment, encouraging differentiation and tissue formation; and to have ideal rheological properties to allow extrusion 3D bioprinting. Bioink with a unique blend of crystal and fibril nanocellulose produces a very stable construct volume in culture.
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
A glass laminate structure is disclosed with a first and a second glass ply and a printed polymer ply interposed between the first and second glass plies, the printed polymer ply may be of PVB or PET having nanoparticle-containing ink adhered to at least a portion of a surface. Optionally there may be at least one further polymer ply which may be of PVB, PVA, COP or TPU. The nanoparticle-containing ink may contain electrically conductive nanoparticles, especially silver nanoparticle-containing ink. Also disclosed is a process for producing such a glass laminate structure.
H05B 3/84 - Heating arrangements specially adapted for transparent or reflecting areas, e.g. for demisting or de-icing windows, mirrors or vehicle windshields
B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
The invention relates to a method for the production of single alpha chain collagens and an isolated or purified product comprising single alpha chain collagens.
The invention relates to a method for the production of single alpha chain collagens and an isolated or purified product comprising single alpha chain collagens.
The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active against at least one gene encoding a cancer promoting or sustaining protein such as an oncogene, a chemo-resistant gene or a metabolic gene; siRNA cassette encoding at least one siRNA active against said gene; a bacterial cell with said siRNA cassette integrated within the bacterial chromosome; a method of treating cancer, particularly but not exclusively prostate, breast or colorectal cancer, employing the use of said bacterial cell with a chromosomally integrated siRNA cassette; and use of said bacterial cell with a chromosomally integrated siRNA cassette to treat said cancer.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
The invention provides a device (100, 200, 300) and method for determining the strength of a magnetic field normal to a two-dimensional electron gas between layers of high bandgap semiconductor material.
UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST (United Kingdom)
Inventor
Velthuis, Johannes Jarig
Page, Ryan Frank
Hugtenburg, Richard Peter
Stevens, Paul
Abstract
A radiation detector with a patterned structure arranged to generate charged particles in response to photons which are incident on the patterned structure. A signal generation layer is arranged to generate signal charge in response to charged particles generated in the patterned structure which are incident on the signal generation layer. A barrier layer is arranged so that the signal generation layer is positioned between the patterned structure and barrier layer and in contact with the patterned structure and barrier layer. The patterned structure and barrier layer trap the signal charge in the signal generation layer. A plurality of collectors are provided, each collector arranged to collect the signal charge trapped in the signal generation layer. The patterned structure is patterned with a varying thickness so that it has a plurality of thick regions interspersed with a plurality of thin regions, a thickness of each of the thick regions being greater than a thickness of each of the thin regions.
The invention concerns multicomponent metallic alloys and processes for preparing the same. In particular, the invention is directed to new high entropy alloys ('HEAs'); to catalyst compositions comprising said HEAs; and to the use of said HEAs as electrochemical catalysts. The invention also provides a method for preparing multicomponent metallic alloys which include, but are not limited to, said HEAs.
A computer-implemented apparatus for performing a genotoxicity assessment in respect of a population of labelled cells pre-treated with, or exposed to, one or more specified substances, conditions and/or environments. The apparatus comprises a imaging flow cytometry system (10) for capturing image files representative of said cell population, wherein each image file is representative of a single cell of said population, a cell-image analysis module (12) configured to receive said image files and generate, in respect of each one thereof, respective cytological profiles; and a machine learning module (14) configured to receive said cytological profiles and, in respect of each of a plurality thereof obtain therefrom one or more characteristics and insert their respective value(s) into a predetermined algorithm to generate a classifier and compare said generated classifier with a predetermined rule to output a score for the respective cell.
The present invention relates to a valve arrangement particularly, but not exclusively, for use in dampers to control compression and optionally rebound properties of a shock absorber wherein the valve arrangement comprising a valve body having a first and second fluid flow pathway for enabling fluid flow from an upstream to a downstream location and the valve arrangement further comprises a plurality of operational configurations for controlling the flow rate of fluid flow.
F16F 9/46 - Means on or in the damper for manual or non-automatic adjustmentSprings, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium Details such means combined with temperature correction allowing control from a distance
F16K 1/00 - Lift valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces
F16F 9/348 - Throttling passages in the form of annular discs operating in opposite directions
46.
DYNAMIC ACTIVE AND REACTIVE POWER LOAD SHARING IN AN ISLANDED MICROGRID
A method of managing a microgrid and control system is provided, in which the virtual resistance control gains (in αβ frame) of each respective inverter is dynamically adjusted based on a variable related to the available power from each of a plurality of renewable distributed generators.
The present invention concerns a method for manufacturing a proppant for a particular stimulation fluid, or for manufacturing a stimulation fluid for a particular proppant. The present invention also concerns a proppant for hydrocarbon stimulation, wherein the proppant comprises a plurality of amorphous spherical glass particles which have not undergone any further chemical or thermal treatment, a method of preparing the proppant, and uses of the proppant in hydrocarbon stimulation.
The present invention relates to a platform that may be utilised in the field of biosensors. According to the present invention there is a method of manufacturing a platform for use in bio-sensing applications comprising the steps of: • a) providing a substrate (10) having electrodes (12) thereon; • b) performing an overprinting step by overprinting the electrodes (12) with a precursor solution; • c) performing a drying step to dry the precursor solution to form a print layer (14) on the electrodes (12); • d) performing a further overprinting step by overprinting the print layer (14) with a precursor solution to increase the print layer thickness; • e) performing a transformation step to at least partially transform the print layer (14) from a first substance to a second substance different to the first substance.
The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.
A micro-grid energy management system is provided which can operate and regulate power, voltage, frequency and phase to a load in both grid-connected and islanded mode, obviating the need for switching between control paradigms.
A glass laminate structure is disclosed with a first and a second glass ply and a printed polymer ply interposed between the first and second glass plies, the printed polymer ply may be of PVB or PET having nanoparticle-containing ink adhered to at least a portion of a surface. Optionally there may be at least one further polymer ply which may be of PVB, PVA, COP or TPU. The nanoparticle-containing ink may contain electrically conductive nanoparticles, especially silver nanoparticle-containing ink. Also disclosed is a process for producing such a glass laminate structure.
H05B 3/84 - Heating arrangements specially adapted for transparent or reflecting areas, e.g. for demisting or de-icing windows, mirrors or vehicle windshields
B32B 17/10 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like comprising glass as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
52.
METHOD OF DETECTING BACTERIAL INFECTION IN A BIOLOGICAL SAMPLE
A method of indicating the presence of a bacterial infection in a biological sample is provided. The method detects a marker for infection by providing a device, the device including a biosensor, an interaction arising between the biosensor and the marker when the marker is present in the biological sample. Contacting at least a part of the biological sample with the biosensor of the device, therefore, provides analysis of the biological sample with respect to the marker by detecting for the interaction between the biosensor and the marker. A preferred marker is the enzyme amylase.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
The present invention relates to a process and apparatus for processing waste water, particularly acid mine discharge (AMD) that contains heavy metals. The system comprises a treatment zone having a substrate for growing an algae biofilm thereon and also comprises a nutrient source for supplying nutrients to the treatment zone.
A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation End (RAGE) products linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosis or polycystic ovary syndrome. Novel cell binding agents, pharmaceutical compositions and methods are also described and claimed.
A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active against at least one gene encoding a cancer promoting or sustaining protein such as an oncogene, a chemo-resistant gene or a metabolic gene; siRNA cassette encoding at least one siRNA active against said gene; a bacterial cell with said siRNA cassette integrated within the bacterial chromosome; a method of treating cancer, particularly but not exclusively prostate,breast or colorectal cancer, employing the use of said bacterial cell with a chromosomally integrated siRNA cassette; and use of said bacterial cell with a chromosomally integrated siRNA cassette to treat said cancer.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
The present invention relates to a corrosion inhibitor and inhibitor provided within a coating material for coating a metal, particularly but not exclusively steel. The corrosion inhibitor in a coating particularly protects a sacrificial coating such as zinc or zinc alloy on galvanised steel which in turn therefore provides improved corrosion resistance to the underlying steel. According to an aspect of the invention there is a corrosion inhibitor provided in a polymer binder, the corrosion inhibitor comprising an organic ion in an ion exchange resin.
C23F 11/00 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent
C23F 11/08 - Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids
The present invention relates to methods for the diagnosis or prognosis of conditions caused by defects in cholesterol biosynthesis, such as Smith-Lemli-Opitz syndrome (SLOS), in particular to early diagnostic methods including in utero methods. In one aspect, the method compries detecting in a biological sample levels of delta-5 bile acid conjugated with 2-(acetylamino)-2-deoxy-D-glucose (GlcNAc) of formula (I)
The invention relates to a genetically transformed or transfected bacterial cell of a gut symbiont of an insect belonging to the Order Thysanoptera wherein said cell is transformed to express double-stranded RNA (dsRNA) active against at least one selected insect gene; a vector for transforming or transfecting said bacterial cell; an insect including said transformed bacterial cell and a method of pest control employing the use of said bacterial cell and/or said insect.
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
An apparatus, in the form of a headset (20), to deliver stimulation to the brain of an individual which has a support member (22) with two ends each having an earpiece (24). The support member is configured to pass from the first earpiece over the skull of the individual to the second earpiece, wherein the support member also has at least one locator to which at least one electrode can be secured so that at least one electrode (30) when attached to the support member is located forward of the support member so as to be in proximity to the front lobes of the skull so that electrical stimulation can be delivered to the individual's brain at precise locations.
The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of bacteria, and are useful in the treatment or prophylaxis of a bacterial infection in an animal.
C07C 279/04 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
C07C 279/18 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
C07C 281/18 - Compounds containing any of the groups e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation Endproducts (RAGE) linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosisor polycystic ovary syndrome. Cell binding agents, pharmaceutical compositions and methods are also described and claimed.
A61K 47/66 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
A therapeutic agent comprising a cell binding agent which binds the Receptor for Advanced Glycation Endproducts (RAGE) linked to an anti-cancer drug, for use in the treatment of gynaecological cancer, endometriosisor polycystic ovary syndrome. Cell binding agents, pharmaceutical compositions and methods are also described and claimed.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
63.
ACCESS PORT ARRANGEMENT AND METHOD OF FORMING THEREOF
The present invention relates to an access port arrangement and in particular an access port arrangement capable of enabling stirring of a molten metal in a vessel. Such arrangements are often called tuyeres. The access port arrangement comprises an inner part forming a core with an outer periphery and an outer part comprising a bore therethrough having an inner periphery positioned around the outer periphery of the inner part with the path way defined by a gap between the outer periphery of the inner part and the inner periphery on the outer part. The arrangement further comprises one or more bridges that span the gap between the outer periphery of the inner part and the inner periphery of the outer part. The inner and outer part are formed of a refractory material.
A reagent selected from cholestenoic acid or an inhibitor of an enzyme in the cholestenoic acid biosynthetic or metabolic pathway for use in the treatment of neurodegenerative conditions. In particular, the reagent is a cholestenoic acid of a particular form, such as 3β,7α-dihydroxycholest-5-en-26-oic (3β,7α-diHCA), not previously associated with neural tissue or CSF. Pharmaceutical compositions, methods of treatment or prevention of neurodegenerative conditions as well as diagnostic methods and novel biomarkers form further aspects of the invention.
G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A computer-implemented method for the label-free classification of cells using image cytometry is provided. In some exemplary embodiments of the computer implemented method, the classification is the classification of the cells, such as individual cells, into a phase of the cell cycle or by cell type. A user computing device receives as an input one or more images of a cell obtained from a image cytometer. The user computing device extracts features form the one or more images, such as brightfield and/or darkfield images. The user computing device classifies the cell in the one or more images based on the extracted features using a cell classifier. The user computing device then outputs the class label of the cell, as defined by the classifier.
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (Canada)
Inventor
Cookson, William O.C.M.
Moffatt, Miriam F.
Laprise, Catherine
Lathrop, Mark
Liang, Liming
Davies, Gwyneth
Abstract
A method of identifying a subject falling within a new patient population characterised by eosinophil IgE mediated allergic inflammation, involving analysing the level of methylation in a DNA sample obtained from the subject for one or more promoter regions associated with one or more genes. Individuals within this new patient population are expected to be likely to respond to therapies for eosinophil IgE mediated inflammation, such as inhibitors of IL-5, IL-13, IgE or M1 prime activity and other therapies directed towards eosinophils.
A method of forming a nanostructured material by mixing particles with linkage units in a single phase so that the linkage units can join together particles. The linkage units are then removed in whole or in part to bring the particles into proximity so that an ordered structure is obtained as shown in Figure 6. The nanostructured material that is formed has a more even distribution of particles and increased surface connectivity making these materials particularly suited to applications where the surface are of the material is important
A photovoltaic device (1) is made by providing a substrate (10) and forming a compact layer (30) on the substrate. The compact layer is coated with a layer (40) including metal oxide nanoperticles (50) and perovskites (60). NIK radiation Is used to cure the layer so that a scaffold is provided for the perovskites which can allow for light absorption and electron transportation In the compact layer when exposed to light. There is also an electrode (80) attached to the scaffold. The method allows for the manufacture of photovoltaic devices very efficiently and rapidly making it a very economical process.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
A method of forming microneedles (28) where through a series of coating and etching processes microneedles are formed from a surface as an array. The microneedles have a bevelled end and bore which are formed as part of the process with no need use a post manufacturing process to finish the microneedle.
Compounds of general formula (I) wherein (I) R1 - R4 are each independently selected from H and deuterium; and at least one of R1 - R4 is deuterium. The compounds have been found to be particularly useful for treating neurodegenerative conditions and in particular but not exclusively conditions such as motor neurone disease.
The present invention relates to a module of opto-electronic devices, which comprises a plurality of opto-electronic devices arranged on a first electrically insulating carrier substrate to define a plurality of interconnection regions between the opto-electronic devices, with each opto-electronic device comprising: - an upper device component that comprises a second electrically insulating carrier substrate and a counter electrode made of a metal, a conductive oxide or a conductive organic compound; - a lower device component that comprises a working electrode, a blocking layer, an active layer, a hole conducting layer and a lower contact layer, and - a conductive adhesive disposed between the upper device component and the lower device component, wherein the conductive adhesive disposed between the upper device component and the lower device component is a transparent conductive adhesive and an interconnecting conductive adhesive is provided in each interconnection region between, and in electrical contact with, the counter electrode of one opto-electronic device and a working electrode of an adjacent opto- electronic device for interconnecting the opto-electronic devices in series.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 27/30 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including components using organic materials as the active part, or using a combination of organic materials with other materials as the active part with components specially adapted for either the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
A topical drug delivery patch (1) comprising a drug delivery layer (3) including microspheres (2) encapsulating a drug, said microspheres being carried in a hydro gel. The drug delivery layer has a support layer (5) which is attached to a first face of the drug deliver layer and a releasable protective layer (4) attached to a second face of the drug delivery layer. The releasable protective layer can be peeled away do the patch can be applied to the skin to release drugs in the microspheres. The patch is particularly useful for treating skin conditions such as psoriasis and eczema.
A microneedle device (200) including at least one microneedle (1) having one or more nanowires (203) on a surface of said at least one microneedle. The microneedle device is typically used in a sensor such as a sensor for monitoring glucose levels in the body and the nanowires may have a membrane (207) covering at least part of the nanowires.
A sensor (1) is formed of a graphene or silicon based nanostructure (10) having a flow path (21) which may be a channel or nanowire. The flow path is functionalised to attract certain molecules. The flow path has contacts (22) at either and the loading of the functionalised flow path alters the charge on that path and gives a measurement of the molecules. The sensor can provide a particularly sensitive device which can monitor a number of biomolecules in real-time, and in particular molecules associated with stress.
The present invention relates to a opto-electronic device which comprises: (a) an upper device component comprising: a counter electrode made of a metal, a conductive oxide or a conductive organic compound; (b) a lower device component comprising: a glass or polymeric carrier substrate, a working electrode comprising a transparent conductive coating adjacent to the glass or polymeric substrate, a blocking layer, an active layer, a hole conducting layer, (c) a conductive adhesive disposed between the upper device component and the lower upper device component, and (d) a contact layer for facilitating the injection of electrons into the active layer, between and in contact with, the conductive adhesive and the hole conducting layer.
H01L 51/44 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation - Details of devices
H01L 51/48 - Processes or apparatus specially adapted for the manufacture or treatment of such devices or of parts thereof
An inhibitor of ghrelin de-acylation (GDAi) such as an APT1 inhibitor for use in the treatment or prophylaxis of physiological or pathophysiologicial conditions that are mediated by acylated ghrelin (AG) and un-acylated ghrelin (UAG) in mammals. Such conditions include CNS disorders such as Alzheimer's disease and Parkinson's disease. Peripheral administration of the inhibitors is a useful method of treatment for such conditions. Also, the ratio of AG to UAG (as well as the GDA enzyme content or GDA enzyme activity) can be a useful biomarker that may be used as the basis of diagnostic techniques.
A method of removing contaminants from liquid passing over a surface by applying a photocatalyst to said surface 2, such that when a liquid passes over said surface in the presence of solar power, contaminants are degraded to less harmful compounds in said liquid. The photocatalyst is typically titanium dioxide applied as a coating on a surface such as glass or metal and can be used to degrade contaminants in effluents from industrial processes such as the textile or paper industries when liquid from those processes flows over the coating.
The photovoltaic device is formed by coating a substrate with a transparent conducting oxide and then this layer is coated with a dioxide layer. The dioxide layer is then coated in a single step with a precursor solution including metal oxide nanoparticles and perovskites and this precursor can be heated to form a scaffold having a perovskite light absorber and electron transporter. A conductor is added to form a connection with the scaffold and it is envisaged that because a single step relatively low temperature process is used to form the scaffold then this can be painted onto a surface and cured in situ making it a very economical process.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
79.
COMPOUND AND METHOD FOR THE TREATMENT AND DIAGNOSIS OF NEURODEGENERATIVE CONDITIONS
A reagent selected from cholestenoic acid or an inhibitor of an enzyme in the cholestenoic acid biosynthetic or metabolic pathway for use in the treatment of neurodegenerative conditions. In particular, the reagent is a cholestenoic acid of a particular form, such as 3β,7α-dihydroxycholest-5 -en-26-oic (3β,7α-di HCA), not previously associated with neural tissue or CSF. Pharmaceutical compositions, methods of treatment or prevention of neurodegenerative conditions as well as diagnostic methods and novel biomarkers form further aspects of the invention.
The present invention provides a heating element (L) formed as a laminate including a thermally conductive substrate (1) having a first surface coated at least in part with an electrically insulating coating layer (2). The electrically insulating layer is backed with an electrically resistive layer (3), formed of a non-conducting matrix material that is loaded with conductive material to allow current to be passed through the resistive material to generate heat which can be conducted out through the thermally conductive substrate (1). An electrically and thermally insulating layer (6) backs layer (3) and direct heat through the second surface and to provide support and encapsulation to the resistive element of the system.
H05B 3/14 - Heating elements characterised by the composition or nature of the materials or by the arrangement of the conductor characterised by the composition or nature of the conductive material the material being non-metallic
H05B 3/26 - Heating elements having extended surface area substantially in a two-dimensional plane, e.g. plate-heater non-flexible heating conductor mounted on insulating base
81.
AN OPTO-ELECTRONIC DEVICE AND METHOD FOR MANUFACTURING THE SAME
The present invention relates to an opto-electronic device comprising: • (a) a first component (2) comprising a transparent electrode, and • (b) a second component (3) comprising: • - a metal substrate (5), • - a blocking layer (7), • - an active layer (8), and • - a hole conducting layer (9, 10), wherein the metal substrate is provided with a plating layer (6) between the metal substrate and the blocking layer.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 51/44 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation - Details of devices
Use of a compound of Formula (1) to modify the behavior of insects of the order Thysanoptera (thrips), wherein the compound of Formula (1) has the following structure: where: Rl is a methyl group: R2 is a hydrogen group: R3 a ketone group or a hydrogen group: R4 and R6 are selected from hydrogen, methyl or ethyl groups and share a methyl and R5 is a hydrogen group.
A01N 25/18 - Vapour or smoke emitting compositions with delayed or sustained release
A01N 49/00 - Biocides, pest repellants or attractants, or plant growth regulators containing compounds containing the group wherein m+n≥1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group wherein A means a carbon atom or Y, n ≥ 0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
A01N 31/06 - Oxygen or sulfur directly attached to a cycloaliphatic ring system
A mixture for the control of insects based on a-pinene, β-pinene, 3-carene. The mixture may also include myrcene. The mixture provides a way of controlling insects, in particular those that damage forestry crops by controlling insect behaviour throughout the life cycle of those insects while still being environmentally safe to use.
A01N 49/00 - Biocides, pest repellants or attractants, or plant growth regulators containing compounds containing the group wherein m+n≥1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group wherein A means a carbon atom or Y, n ≥ 0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
84.
METHOD AND APPARATUSES FOR INTERACTIVE SEARCHING OF ELECTRONIC DOCUMENTS
Interactive extraction of information and interactive searching of an electronic document, where there is formulation of a query to extract specific information from a given part of the electronic document while preserving technical and scientific information quality and accuracy; the process involving a query-controlled automatic segmentation of the given part of the electronic document into a plurality of terms represented as a weighted directed graph; query-controlled automatic classification of each of these terms by associating it with type and feature vector; query-controlled relevance scoring of each of these terms; query-controlled automatic selection of a subset of these terms; and automated composition of the system output guaranteeing to have at least some minimum level of coherence to be presented to the user.
The invention relates to a kit and methods for quantitative detection of steroids in a sample. The kit comprises quantitative charge tags and an oxidising agent.
The present invention relates to an opto-electronic device comprising: a first component comprising an electrode, an active layer and a first transparent conductive layer; a second component comprising a transparent electrode, and a transparent adhesive disposed between the first component and the second component, wherein the transparent electrode comprises a metal or metal alloy current collector and the transparent adhesive comprises one or more conductive components.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
A counter electrode generally shown as 1 is formed of a conductive substrate e.g. a glass substrate 10 on which is deposited doped oxide, e.g. a fluorine doped tin oxide 20. Overlaying the fluorine layer is a layer of a metal halide, e.g. platinum chloride 30 (5Mm H2PtCI6(H2O)6) in isoproply alcohol. Metal is deposited from the solution by treating with NIR. The tin oxide layer renders the glass electrically conductive, absorbs significantly in the NIR and allows for the subsequent heating of the Pt-CI via a heat transfer process to make the counter electrode in a very efficient manner.
A biological fluid monitoring device is shown generally as 1 in Figure 1. The device consists of microneedles (20) to take up a biological fluid from an individual, a reservoir (30) for receiving the fluid and a sensor (40), associated with microstructures (41), that is housed within the reservoir and which analyzes the blood components and composition. The device is connected to transmitter (51) which can send data in real time about analytes that are being monitored in the biological fluid.
The invention concerns a genetically transformed or transfected bacterial cell wherein said bacteria is a gut symbiont of an insect vector or insect pest; characterised in that said bacterial cell is transformed to express dsRNA against at least one selected target gene of the insect vector, whereby the effect or viability of said insect is deleteriously compromised; also an insect including said bacterial cell and a method of modulating a target insect gene using said bacterial cell.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
A01N 63/00 - Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
As shown in Figure 4, substrate (1) has printed areas on it and these areas include a biological molecule which has been printed on the surface using a rotary printing press methods to allow for rapid and high quality printing. The printing formulation includes poly(vinyl alcohol) which provides an appropriate viscosity to allow for printing without damaging the properties of the biological molecule.
C07D 241/08 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
C07D 273/08 - Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups having two nitrogen atoms and more than one oxygen atom
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/5395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A method of transforming a stream of wide-angle video frames, the method comprising mapping each video frame onto a spherical mesh selecting one or more features present in a number of the video frames for each frame, generating a energy equation for each of a plurality of image transformation criteria and minimising the energy equations to define an image transformation and applying the image transformation to the spherical mesh for said frame, wherein one of the transformation criteria comprises a measure of temporal coherency between successive frames, whereby the minimisation of each energy equation for each frame includes minimising the change in transformation applied to the selected features between successive frames.
A LAB ON A CHIP Figure 1 shows the cross-sectional view of the microchip, which in this case is provided in the form of a silicon wafer. The microchip has an upper surface (2) and a lower surface (3). The upper surface (2) has at least one opening (4) which extends into the microchip and is filled with a dielectric such as silicon dioxide. In the bottom wall there is a channel (5) which is aligned with the opening (4) and provides an optical passage through the microchip.
G01Q 30/02 - Non-SPM analysing devices, e.g. SEM [Scanning Electron Microscope], spectrometer or optical microscope
G02B 1/02 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of crystals, e.g. rock-salt, semiconductors
UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST (United Kingdom)
Inventor
Veltius, Jaap
Hugtenburg, Richard, Peter
Hall, Catherine
Page, Ryan
Stevens, Paul
Abstract
A radiation beam, for example a therapeutic radiation beam such as an IMRT or VMAT X-ray beam is monitored using a Monolithic Active Pixel Sensor (MAPS) detector. Photons of the radiation beam can interact with the MAPS detector, and the radiation beam configuration can be estimated from the determined positions of the interactions. The detector is made sufficiently thin that it interacts only very weakly with the X-ray photons. For example, less than 1 in 103 of the X-ray photons might interact with the detector. Hence, the disturbance to the X-ray beam is negligible.
Provided are methods for diagnosing lung cancer in a subject or for identifying a subject at risk of developing lung cancer, the method comprising performing FTIR spectral analysis of a sputum sample obtained from the subject and comparing the spectrum produced from the sample with an FTIR spectrum from a normal control. Also provided are methods for detecting early and late stage cancer, methods for monitoring the progression of lung cancer in a subject and kits for use in the described methods.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
97.
MATERIAL ANALYSIS DEVICE BASED ON EDGE-EMITTER SEMICONDUCTOR LASER CHRYSTAL, AND ASSICIATED ANALYSIS TOOL
UNIVERSITY COLLEGE CARDIFF CONSULTANTS LTD (United Kingdom)
SWANSEA UNIVERSITY (United Kingdom)
Inventor
Summers, Huw
Rees, Paul
Abstract
An edge-emitter semiconductor laser crystal having a receptacle for sample material which can influence the crystal's laser operation. There may be separate zones of laser action within the crystal, creating respective sensing zones in the receptacle. Detection may be achieved by providing photo-diode regions within the crystal, for example.
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 33/487 - Physical analysis of biological material of liquid biological material
H01S 5/026 - Monolithically integrated components, e.g. waveguides, monitoring photo-detectors or drivers
H01S 5/06 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium
H01S 5/40 - Arrangement of two or more semiconductor lasers, not provided for in groups
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
