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Found results for
 patents
1.
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Oxidation process for preparing 3-formyl-cephem derivatives
| Application Number |
14680548 |
| Grant Number |
09499566 |
| Status |
In Force |
| Filing Date |
2015-04-07 |
| First Publication Date |
2015-08-06 |
| Grant Date |
2016-11-22 |
| Owner |
Basilea Pharmaceutica International (Switzerland)
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| Inventor |
Maria Vervest, Ivan Joseph
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Abstract
The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for the preparation of 7-[2-(5-amino-[1,2,4]thia-diazol-3-yl)-2-hydroxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivatives of formula (I) using a combination of a hypervalent iodine oxidizing agent of the type 10-I-3 such as bis(acetoxy)iodo-benzene (BAIB) and a catalyst such as 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). These compounds of formula (I) are intermediates in the synthesis of ceftobiprole.
IPC Classes ?
- C07D 501/04 - Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D 501/34 - Methylene radicals, substituted by oxygen atomsLactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
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2.
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Oxidation process for preparing 3-formyl-cephem derivatives
| Application Number |
13696151 |
| Grant Number |
09006422 |
| Status |
In Force |
| Filing Date |
2011-05-09 |
| First Publication Date |
2013-03-14 |
| Grant Date |
2015-04-14 |
| Owner |
Basilea Pharmaceutica International Ltd. (Switzerland)
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| Inventor |
Vervest, Ivan Joseph Maria
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Abstract
The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for the preparation of 7-[2-(5-amino-[1,2,4]thia-diazol-3-yl)-2-hydroxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivatives of formula (I) using a combination of a hypervalent iodine oxidizing agent of the type 10-I-3 such as bis(acetoxy)iodo-benzene (BAIB) and a catalyst such as 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). These compounds of formula (I) are intermediates in the synthesis of ceftobiprole.
IPC Classes ?
- C07D 501/34 - Methylene radicals, substituted by oxygen atomsLactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
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3.
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OXIDATION PROCESS FOR PREPARING 3-FORMYL-CEPHEM DERIVATIVES
| Application Number |
EP2011057404 |
| Publication Number |
2011/141415 |
| Status |
In Force |
| Filing Date |
2011-05-09 |
| Publication Date |
2011-11-17 |
| Owner |
BASILEA PHARMACEUTICA INTERNATIONAL LTD. (Switzerland)
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| Inventor |
Vervest, Ivan, Joseph, Maria
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Abstract
The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for the preparation of 7-[2-(5-amino-[1,2,4]thia-diazol-3-yl)-2-hydroxyimino-acetylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivatives of formula (I) using a combination of a hypervalent iodine oxidizing agent of the type 10-I-3 such as bis(acetoxy)iodo-benzene (BAIB) and a catalyst such as 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO). These compounds of formula (I) are intermediates in the synthesis of ceftobiprole.
IPC Classes ?
- C07D 501/34 - Methylene radicals, substituted by oxygen atomsLactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
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