Abstract

A nanonization method for cannabidiol (CBD) includes following steps: the CBD is dissolved in a good solvent to obtain a CBD-good solvent solution, the CBD-good solvent solution is added to aqueous solution of a stabilizer to obtain mixed solution, the mixed solution is ultrasonicated followed by removing the good solvent by rotary evaporation from the mixed solution to obtain a nanosized CBD suspension. The stabilizer includes one or more selected from the group consisting of poloxamer, tween, polyoxyethylene alkyl ether, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose and carboxymethyl chitosan. Particle size of the CBD is reduced in the nanonization method for the CBD through the nanonization of insoluble drugs to obtain the nanosized CBD suspension. In the nanosized CBD suspension, nanosized CBD has high solid content. The nanonization method for the CBD achieves solubilization of the CBD.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/38 - CelluloseDerivatives thereof
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A linear compressor, comprising a housing (1), and a first air cylinder (2), a first piston (3), a second air cylinder (4), a second piston (5), a connecting member (6), a stator (10), a mover (11), and a back cavity (7) that are arranged in the housing (1). The first air cylinder (2) comprises a first compression cavity (21). The first piston (3) is movably arranged in the first compression cavity (21). The second air cylinder (4) comprises a second compression cavity (41). The second piston (5) is movably arranged in the second compression cavity (41). The first air cylinder (2) and the second air cylinder (4) are coaxially arranged. The first piston (3) and the second piston (5) are coaxially arranged and connected by means of the connecting member (6), so as to achieve synchronous movement. The stator (10) and the mover (11) are arranged at the side relatively close to the first air cylinder (2), and the mover (11) is fixed to the connecting member (6) and synchronously moves with the first piston (3). The linear compressor facilitates elimination of the drift of the pistons, and the output performance of the linear compressor is optimized.

IPC Classes  ?

• F04B 35/04 - Piston pumps specially adapted for elastic fluids and characterised by the driving means to their working members, or by combination with, or adaptation to, specific driving engines or motors, not otherwise provided for the means being electric

Abstract

An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

Disclosed is a thermoacoustic reactor system, comprising: a thermoacoustic reactor plant which comprises a reactor, a heat regenerator (2) connected to the reactor, a heat exchanger (1) connected to the heat regenerator (2), a phase modulator (6) connected between the reactor and the heat exchanger (1), and an electric generator piston (7) driven by energy generated by the reactor; and further comprising a pressure-bearing housing (9) which is arranged outside of the thermoacoustic reactor plant and closes the thermoacoustic reactor plant, with the interior of the thermoacoustic reactor plant being in communication with the internal space of the pressure-bearing housing (9). In the thermoacoustic reactor system, by means of placing the thermoacoustic reactor plant in the closed pressure-bearing housing (9), the average pressure in the pressure-bearing housing (9) is equal to the average pressure in the thermoacoustic reactor plant, such that the pressure-bearing wall surface of the heat regenerator (2) no longer bears the average pressure difference, which can greatly reduce the thickness of the pressure-bearing wall surface of the heat regenerator (2) in order to make full use of the maximum power of a thermoacoustic electric generator.

IPC Classes  ?

• G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
• G21D 5/06 - Reactor and engine not structurally combined with engine working medium circulating through reactor core
• F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for

Abstract

A gypsum magnetic seed crystal scale inhibition and removal system and an evaporation and crystallization system, the gypsum magnetic seed crystal scale inhibition and removal system comprising a seed crystal circulation sub system, wherein the seed crystal circulation sub system is connected to equipment to be treated by means of a pipeline so as to form a seed crystal circulation loop; the seed crystal circulation sub system comprises a magnetic field generation device (2); and the magnetic field generation device (2) is configured to magnetize gypsum seed crystals flowing through the magnetic field generation device so as to form gypsum magnetic seed crystals. The evaporation and crystallization system comprises a crystallizer (8) and the seed crystal circulation sub system; and the seed crystal circulation sub system is connected to the crystallizer (8) by means of a pipeline so as to form a seed crystal circulation loop. By means of magnetizing the seed crystals to inhibit and remove scales of the equipment to be treated, the magnetized seed crystals circulate and flow between the equipment to be treated and the seed crystal circulation sub system to stably maintain the magnetizing state of the seed crystals. Therefore, the scale inhibition and removal effects are enhanced.

IPC Classes  ?

• C02F 1/04 - Treatment of water, waste water, or sewage by heating by distillation or evaporation

Abstract

A combined cycle room temperature refrigeration/heat pump double-effect system, comprising a linear compressor (1), a regenerative thermal unit (2) connected to the linear compressor (1) by means of a metal film (18), and a vapor compression throttling thermal unit (3) directly connected to the linear compressor (1) by means of a gas passage.

IPC Classes  ?

• F25B 9/00 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point

Abstract

Disclosed is a thermoacoustic engine, comprising at least one thermoacoustic engine unit. The thermoacoustic engine unit comprises a main water cooler (1), a heat regenerator (2), and a nuclear fuel heater (3) that are successively connected, wherein the nuclear fuel heater (3) exchanges heat with a working gas flowing through the nuclear fuel heater (3) by using a nuclear fuel reaction, such that the temperature of the working gas is raised. The thermoacoustic engine solves the problems of complex energy transmission, a low thermal energy grade and an enormous system in a nuclear pile thermal energy utilization process, and solves the problem that it is difficult for a heater of an external-heat-type thermoacoustic engine to realize heat exchange in an ultra-temperature and ultra-high heat flux density, provides a novel nuclear energy utilization approach, improves the efficiency and safety of nuclear energy utilization, and enables a system to be more compact.

IPC Classes  ?

• F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for

Abstract

An electrically conductive shredded tobacco atomizing device and an electrically conductive shredded tobacco pipe using the same, pertaining to the technical field of electronic atomization. The electrically conductive shredded tobacco atomizing device comprises a housing (1) and an electromagnetic generator (2) disposed in the housing (1). The electromagnetic generator (2) comprises an electromagnetic coil (21). Electrically conductive shredded tobacco (3) is placed in the housing (1). The electromagnetic coil (21) is distributed at an outer side of the electrically conductive shredded tobacco (3). The electromagnetic coil (21) generates an alternating magnetic field upon energization, and the electrically conductive shredded tobacco (3) is heated under the action of an eddy current in the magnetic field of the electromagnetic coil (21) to release active ingredients. The electrically conductive shredded tobacco atomizing device does not require an additional heating member. The alternating magnetic field of the electromagnetic coil (21) causes an induction current to be generated in the electrically conductive shredded tobacco to directly heat the same, such that active ingredients in the shredded tobacco are released, the heat is generated and transferred evenly, and the heating time is short and highly efficient.

IPC Classes  ?

• A24F 47/00 - Smokers’ requisites not otherwise provided for