This disclosure provides methods and compositions for the production of engineered eukaryotic cells wherein the production of both glutaminase isozymes (Gls and Gls2) and asparaginase (Aspg) is reduced such that ammonia production is almost entirely eliminated before stationary phase and substantially decreases it over the course of culture, even when grown in glutamine-containing medium.
The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.
The present invention provides novel PSMA targeting urea-based ligands that binds to prostate-specific membrane antigen (PSMA) which is expressed 8-to-12-fold higher in prostate cancer cells when compared to healthy tissue. The PSMA targeting urea-based ligands comprises a chelating agent that may comprise a metal and a halogen radioisotope of fluorine, iodine, bromine or astatine. The invention further relates to a method for providing the PSMA targeting urea-based ligands of the invention, to precursors of the PSMA targeting urea-based ligands and to the PSMA targeting urea-based ligands use in radiotherapy, imaging and theranostic.
The present invention discloses halimide and plinabulin and structural analogues and their use in the treatment and prevention in epilepsy and other seizures. The present invention further discloses methods to screen halimide-like molecules as pharmaceutically active compounds.
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/02 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings
5.
Asparaginase based selection system for heterologous protein expression in mammalian cells
A non-naturally occurring cell comprising an inoperative genomic asparaginase (Aspg) gene and an inoperative glutamine synthetase (Gs) gene, wherein the cell has been transfected with a controllably expressed gene encoding an enzyme having asparaginase activity, a controllably expressed gene encoding an enzyme having glutamine synthetase activity, and a controllably expressed gene encoding a heterologous protein of interest.
The present invention relates to a composition comprising non-water soluble dissacharides and oil, a solvent and at least one pharmaceutical ingredient, wherein the composition contains at least two compounds selected from saccharides and lipid oils such as lactose octabenzoate Methyl hepta-O-isobutyryl-α,β-lactoside, α,β-Lactose octa para-iodobenzoate, 3-iodobenzyl hepta-O-isobutyryl-α,β-lactoside, lactose octapropionate, lactose octaisobutyrate, sucrose octabenzoate, glycerol trihexanoate, Glycerol trioctanoate, Glycerol tridecanoate, Lipiodol, ethyl myristate, ethyl palmitate, ethyl oleoate and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 2,000 centipoise (cP) after administration.
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings
A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
7.
GLYMPHATIC DELIVERY BY MANIPULATING PLASMA OSMOLARITY
The present invention discloses isoquinolines and 1H-2-Benzopyranes and their use in the treatment and prevention in epilepsy and other seizures. The present invention further discloses methods to screen isoquinoline- and 1H-2-Benzopyran-like molecules as pharmaceutically active compounds.
A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
10.
GAMMA STIMULATION PULSING LIGHT SOURCE SYSTEM WITH DOSAGE ADJUSTMENT FOR GAZE ANGLE
Gamma brain stimulation for preventing or treating Alzheimer's disease or sleeping disorders using light or sound is known. A strobing 40 Hz light source has been shown to cause positive effects due to the stimulation. It is an advantage to know the actual dosage of light that enters the person's eyes in order to understand the relationship between dosage and effectiveness. A camera is used to detect the subject's gaze angle, distance, pupil diameter and any other factors that affect the light power that enters the eye. A target dosage is first determined by a medical worker, such as to determine the effects of the exact same dosage on a group persons, such as Alzheimer's patients. With deviations of gaze angle, distance, and pupil size from the ideal, the effective dosage is decreased. The disclosed system adjusts the actual dosage, such as session duration, based on such factors so that the final dosage received by the person is consistent and meets the target dosage.
Gamma brain stimulation for preventing or treating Alzheimer's disease or sleeping disorders using light or sound is known. A strobing 40 Hz light source has been shown to cause positive effects due to the stimulation. It is an advantage to know the actual dosage of light that enters the person's eyes in order to understand the relationship between dosage and effectiveness. A camera is used to detect the subject's gaze angle, distance, pupil diameter and any other factors that affect the light power that enters the eye. A target dosage is first determined by a medical worker, such as to determine the effects of the exact same dosage on a group persons, such as Alzheimer's patients. With deviations of gaze angle, distance, and pupil size from the ideal, the effective dosage is decreased. The disclosed system adjusts the actual dosage, such as session duration, based on such factors so that the final dosage received by the person is consistent and meets the target dosage.
The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.
In an electron tube (1), the meta-surface (S) emits an electron in response to an incidence of the electromagnetic wave. The first and second electrodes (81, 82) are spaced away from each other, and apply potentials different from each other to the meta-surface (S). A holder (30) is disposed in the housing (10) and holds the electron emitter (20). A first conductive line (83) of the meta-surface (S) is electrically connected to the first electrode (81). A second conductive line (84) of the meta-surface (S) is spaced away from the first conductive line (83), and is electrically connected to the second electrode (82). The first conductive line (83) extends from the first electrode (81) to the second conductive line (84). The second conductive line (84) extends from the second electrode (82) to the first conductive line (83).
There is provided an encryption device that is secure against a side channel attack, and can suppress a processing load. The encryption device includes a data encryption part in which at least part of a plurality of round functions for successively performing encryption processing on an input value is tabulated to be encrypted using a white-box model in which input/output values of the round function is able to be recognized from the outside. Each of the round functions includes a tabulated encryption function for encrypting an input value using a black-box model in which the input/output values are able to be recognized from the outside and an intermediate value is not able to be recognized from the outside, and the encryption function is updated with a random number.
G06F 21/54 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by adding security routines or objects to programs
G06F 7/58 - Random or pseudo-random number generators
G06F 21/55 - Detecting local intrusion or implementing counter-measures
Embodiments disclosed herein include novel nucleic acid-guided nucleases, novel guide nucleic acids, and novel targetable nuclease systems, and methods of use. In some embodiments, engineered non-naturally occurring nucleic acid-guided nucleases, can be used with known guide nucleic acids in a targetable nuclease system. In certain embodiments, targetable nuclease systems can be used to edit targeted genomes of humans and other species. In some embodiments, methods include, but are not limited to, recursive genetic engineering and trackable genetic engineering methods.
The present invention relates to an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system comprising engineered dual guide nucleic acids (e.g., RNAs) capable of activating a CRISPR- Associated (Cas) nuclease, such as a type V-A Cas nuclease. Also provided are methods of targeting, editing, and/or modifying a nucleic acid using the engineered CRISPR system, and compositions and cells comprising the engineered CRISPR system.
The present disclosure relates to methods for production of 4-hydroxytryptamine and derivatives thereof in a yeast cell. Herein are also disclosed methods for production of halogenated tryptophans and derivatives thereof in a cell. Herein are also disclosed methods for production of methylated tryptamine. The disclosure also provides nucleic acid constructs and cells useful for performing the present methods.
This invention concerns a photo-cathode for a vacuum system, wherein the photo-cathode is configured for receiving electromagnetic radiation having an incoming wavelength and for emitting electrons in response thereto. The photo-cathode comprises a conducting structure having a geometry, the geometry comprising a tip section. The tip section is adapted to provide field enhancement, β, when the conducting structure is illuminated with the electromagnetic radiation, wherein β is greater than about 102. The photo-cathode further comprising a substrate, the substrate being or comprising a dielectric substrate, the substrate supporting the conducting structure.
An electron tube includes a housing that is internally held in a vacuum and has a window transmitting an electromagnetic wave, an electron emitting unit that is disposed in the housing and has a meta-surface emitting electrons in response to incidence of the electromagnetic wave, an electron multiplying unit that is disposed in the housing and multiplies the electrons emitted from the electron emitting unit, and an electron collecting unit that is disposed in the housing and collects the electrons multiplied by the electron multiplying unit. The window contains at least one selected from quartz, silicon, germanium, sapphire, zinc selenide, zinc sulfide, magnesium fluoride, lithium fluoride, barium fluoride, calcium fluoride, magnesium oxide, and calcium carbonate.
The present invention relates to a composition comprising non-water soluble dissacharides and oil, a solvent and at least one pharmaceutical ingredient, wherein the composition contains at least two compounds selected from saccharides and lipid oils such as lactose octabenzoate Methyl hepta-O-isobutyryl-a,ß-lactoside, a,ß-Lactose octa para-iodobenzoate, 3-iodobenzyl hepta-O-isobutyryl-a,ß-lactoside, lactose octapropionate, lactose octaisobutyrate, sucrose octabenzoate, glycerol trihexanoate, Glycerol trioctanoate, Glycerol tridecanoate, Lipiodol, ethyl myristate, ethyl palmitate, ethyl oleoate and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 2,000 centipoise (cP) after administration.
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
21.
DISSACHARIDE FORMULATIONS FOR CONTROLLED DRUG RELEASE
The present invention relates to a composition comprising non-water soluble dissacharides and oil, a solvent and at least one pharmaceutical ingredient, wherein the composition contains at least two compounds selected from saccharides and lipid oils such as lactose octabenzoate Methyl hepta-O-isobutyryl-α,β-lactoside, α,β-Lactose octa para-iodobenzoate, 3-iodobenzyl hepta-O-isobutyryl-α,β-lactoside, lactose octapropionate, lactose octaisobutyrate, sucrose octabenzoate, glycerol trihexanoate, Glycerol trioctanoate, Glycerol tridecanoate, Lipiodol, ethyl myristate, ethyl palmitate, ethyl oleoate and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 2,000 centipoise (cP) after administration.
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 39/00 - Medicinal preparations containing antigens or antibodies
22.
NEUROTROPHIC FACTOR PROTEIN CONJUGATES AND RELATED EMBODIMENTS
ClostridialClostridial neurotoxin. Vectors, host cells, and methods of use and making are also described. Pharmaceutical compositions comprising the protein conjugates described herein are used to provide neuroprotection and treat neurodegenerative diseases and neuron damage amongst other things.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 14/33 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Clostridium (G)
The method includes the following steps: activating the vacuum source (10), injecting an amount of pulp into the internal mould chamber (3) through the mould opening (7), thereby forming a pulp preform on the internal mould surface (8), injecting a dewatering and heating fluid through the mould opening at gradually increasing pressure until a maximum pressure, thereby performing a dewatering and drying step whereby the pulp preform on the internal mould surface is dewatered and dried, deactivating the injection of dewatering and heating fluid, deactivating the vacuum source, and extracting the moulded pulp product. Further included is a step of initiating rotation of the mould (2) about the central axis (4) of the mould and increasing rotational speed gradually, main-taining a maximum rotational speed of the mould at least during a substantial part of the dewatering and drying step, decreasing rotational speed gradually until standstill of the mould.
There is provided an encryption device to ensure strong security without using a random number in a white-box model. The encryption device includes: an encryption part configured to encrypt an input value using a black-box model in which input/output values are able to be recognized from the outside and an intermediate value is not able to be recognized from the outside; and a key generation part configured to encrypt the input value to the encryption part to generate a cryptographic key of the encryption part using a white-box model in which the input/output value and the intermediate value are able to be recognized from the outside.
H04L 29/06 - Communication control; Communication processing characterised by a protocol
G09C 1/00 - Apparatus or methods whereby a given sequence of signs, e.g. an intelligible text, is transformed into an unintelligible sequence of signs by transposing the signs or groups of signs or by replacing them by others according to a predetermined system
H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
Method of separation of of a radiometal ion from a target metal ion, comprising a first liquid-liquid extraction step in which an organic phase comprising an extractant and an interfacial tension modifier is mixed with an aqueous phase comprising the radiometal ion and the target metal ion in order that the radiometal ion is at least partially transferrred to the organic phase, followed by a first phase separation step, wherein the phase separation is carried out in flow comprising the use of a microfiltration membrane to separate the phases based on the interfacial tension between the phases such that a permeate phase passes through the membrane and a retentate phase does not.
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
A method is provided for calibrating a microfluidic system comprising, which method is based on using beads having a structure based on DNA origami, wherein said structure comprises a predetermined number of fluorophores. Furthermore, methods for determining the level of an antigen using microfluidics calibrated using fluorescent microbeads as provided herein. Also, methods are provided for determining the presence or state of a haematological disease by calibrated a microfluidics system.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
29.
TREATMENT OF EPILEPSY WITH PLINABULIN OR HALIMIDE OR DIKETOPIPERAZINE DERIVATIVES
The present invention discloses halimide and plinabulin and structural analogues and their use in the treatment and prevention in epilepsy and other seizures. The present invention further discloses methods to screen halimide- like molecules as pharmaceutically active compounds.
A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
[Problem] To ensure strong security in a white-box model without the use of random numbers. [Solution] This encryption device is provided with: an encryption unit which encrypts input values by means of a black-box model, in which input and output values can be recognized from the outside and intermediate values cannot be recognized from the outside; and a key generation unit which encrypts input values of the encryption unit by means of a white-box model, in which input and output values and intermediate values can be recognized from the outside, and generates an encryption key of the encryption unit.
G09C 1/00 - Apparatus or methods whereby a given sequence of signs, e.g. an intelligible text, is transformed into an unintelligible sequence of signs by transposing the signs or groups of signs or by replacing them by others according to a predetermined system
32.
ENCRYPTION DEVICE, ENCRYPTION METHOD, DECRYPTION DEVICE, AND DECRYPTION METHOD
[Problem] To provide an encryption calculation which is secure against side channel attacks and which can keep down processing loads. [Solution] This encryption device is provided with a data encryption unit that performs encryption with a white box model in which at least some of multiple rounding functions for sequentially performing encryption processing on input values are tabulated and in which the input and output values of the rounding functions can be recognized from the outside. Each of the aforementioned rounding functions has a tabulated encryption function which encrypts input values in a black box model in which the input and output values can be recognized from the outside and intermediate values cannot be recognized from the outside, and the encryption functions are updated by means of random numbers.
G09C 1/00 - Apparatus or methods whereby a given sequence of signs, e.g. an intelligible text, is transformed into an unintelligible sequence of signs by transposing the signs or groups of signs or by replacing them by others according to a predetermined system
33.
METHODS AND MEDICAL USES RELATING TO THE TREATMENT OF HYPOGLYCAEMIA
REGION HOVEDSTADEN (CAPITAL REGION OF DENMARK) (Denmark)
TECHNICAL UNIVERSITY OF DENMARK (Denmark)
Inventor
Lyngbye Wendt, Sabrina
Ranjan, Ajenthen
Madsen, Henrik
Nørgaard, Kirsten
Bagterp Jørgensen, John
Abstract
Methods and medical uses for determining a dose for a glucagon bolus for administration to patients with diabetes for treating mild or moderate hypoglycaemia, while reducing the risk of, or avoiding, rebound hyperglycaemia are described. This work is based on simulations using pharmacokinetic (PK) and pharmacodynamic (PD) models for glucose, insulin and glucagon to develop an optimum glucagon dosing regimen for treatment of mild or moderate hypoglycaemia depending on ambient insulin levels, while reducing the risk of, or avoiding, rebound hyperglycaemia, for example as may occur when an overly large dose of glucagon is administered to a patient having a hypoglycaemic episode.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
34.
DEVELOPMENT OF INJECTABLE FIDUCIAL MARKERS FOR IMAGE GUIDED RADIOTHERAPY WITH DUAL MRI AND CT VISIBILITY
Radiation therapy or radiotherapy (RT) is a powerful treatment where precision and accuracy is crucial. Image Guided Radiotherapy (IGRT) facilitates more accurate position verification, correcting for anatomic changes related to internal organ movement. IGRT thereby helps reduce toxicity of radiotherapy and increases relapse-free survival. Currently, the most frequently used imaging-technique for IGRT is Computed Tomography (CT). However, CT- based target delineation of soft tissue tumors tends to only improve the precision and not the accuracy of treatment due to its relatively low soft tissue resolution. In some tumors ∼40% larger volumes are defined on CT compared to MRI, a technique with submillimeter soft tissue resolution. Therefore, it is advantageous to apply both CT and MRI in planning of soft tissue tumor radiotherapy. An inter-correlation point with a fixed position and volume (a marker) can be applied to indicate the point of treatment clearly in both imaging modalities and to localize and track tumors in real time. In this study, we present the development of a marker based on lactose octaacetate:octapropionate 1 :1 containing 3 mM PLA-DTPA(Gd), 40% triglyceride, 5% propylene carbonate and 10% XSAIB (sucrose based CT-contrast agent). The injectable marker had high CT contrast (>1000 HU) and displayed clearly visible, stable Ti contrast enhancement (T1 ∼900 ms) in the rim over at least 3 weeks with clinically observable resolution. Key words: Fiducial marker, MRI, CT, Image Guided Radiotherapy
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
TECHNICAL UNIVERSITY OF DENMARK (Denmark)
Inventor
Sasaki Yusuke
Takenaga Katsuhiro
Saitoh Kunimasa
Morioka Toshio
Nooruzzaman Md.
Abstract
A multicore fiber (1A) includes a plurality of cores (11A, 11B) arranged in a matrix, and single cladding (21) surrounding the cores (11A, 11B). An outer shape of a cross-section perpendicular to the longitudinal direction of the cladding (21) is formed into a noncircular shape having the smallest diameter in a prescribed direction and having no recess. Two or more cores (11A, 11B) are arranged in a prescribed direction while a number of cores (11A, 11B) outnumbering the number of the cores arranged in the prescribed direction are arranged in a direction perpendicular to the prescribed direction. The multicore fiber (1A) is bent in a prescribed direction for use.
G02B 6/04 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres
37.
METHOD FOR DETERMINING A DEADZONE ANGLE OF A BACKLASH IN A MECHANICAL DRIVE-TRAIN SYSTEM, METHOD FOR CONTROLLING A DRIVE MOTOR CONTROLLER AS WELL AS DRIVE-TRAIN SYSTEM
The invention relates to a method for determining a deadzone angle (δ) of a backlash in a mechanical drive-train system (1), wherein the drive train-system (1) comprises a drive motor (2), a load (3) and a shaft (4) for connecting the drive motor (2) with the load (3), the method comprising the steps: estimating an interconnection torque (Tl) in the deadzone, determining the deadzone angle (δ) depending on the interconnecting torque (Tl) by means of an adaptive estimator, wherein in the adaptive estimator the backlash is modelled in terms of a variable stiffness (KBL) of the shaft (4).
G05B 19/404 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by control arrangements for compensation, e.g. for backlash, overshoot, tool offset, tool wear, temperature, machine construction errors, load, inertia
The present invention relates to a palpable marker composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 50,000 centipoise (cP) after administration, for use for identifying and/or locating a non palpable tumor. In one embodiment the composition the composition is a liquid before administration into the human or animal body that increases in viscosity by more than 500,000 centipoise (cP) after administration into the human or animal body. In another embodiment the composition is a liquid before administration and has the ability to transform into a crystalline or amorphous solid after administration.
There is provided an encryption device including a data encryption unit configured to conduct encryption on the basis of a white box model in which at least a part of a plurality of round functions for sequentially conducting encryption processing on an input value is tabulated, and input and output values of the round function are recognizable from an outside. The plurality of round functions each have an encryption function that is tabulated and encrypts an input value in a black box model in which input and output values are recognizable from the outside and an intermediate value is not recognizable from the outside.
H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (Japan)
TECHNICAL UNIVERSITY OF DENMARK (Denmark)
Inventor
Sasaki Yusuke
Takenaga Katsuhiro
Saitoh Kunimasa
Morioka Toshio
Abstract
Provided is a multicore fiber containing a plurality of cores, wherein when the multicore fiber is bent to form a curve with a diameter of 280 mm, the optical propagation loss in a mode one order higher than an optical mode used for information transmission in the optical wavelength band used for the information transmission is set between 1 dB/m and 0.02 dB/m inclusive. Thus, unnecessary light in a higher order mode can be sufficiently attenuated within propagation of 1 km. Thereby, even if unnecessary light is created in a higher order mode at a contact point between fibers, the unnecessary light in the higher order mode can be sufficiently attenuated before the next contact point.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
42.
PIPERAZINE INHIBITORS OF BACTERIAL GYRASE AND TOPOISOMERASE IV
This invention relates to a piperazine derivative having the formula (I), wherein R' is selected from -H, -COOH and -CONH2; Ft" is selected from -H, -COOH and -CONH2 with the proviso that when R' is -COOH or -CONH2 then R" is not -COOH or -CONH2, and when R" is -COOH or -CONH2 then R' is not -COOH or -CONH2; A is selected from -(CH2)3-, -(CH2)2CH(OH)-, -CH2-CH=CH- (cis and trans), (a); B is selected from -(CH2)n-, -(CH2)nO-, -(CH2)nS- and -(CH2)n-CH=CH- (cis and trans), (b); and wherein n = 1 -4; and Y is selected from C1-C7 alkyl (straight or branched), C5-C6 cycloalkyi optionally substituted with one or more halogens, thiophene or phenyl optionally substituted with one or more halogens or -C(hal)3 wherein "hal" denotes a halogen, or a pharmaceutically acceptable salt thereof.
C07D 409/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
The present disclosure relates to system applications of multicore optical fibers. One embodiment relates to a base transceiver station for a wireless telecommunication system comprising a plurality of antenna units arranged in a MIMO configuration and adapted for transmission and/or reception of radio-frequency signals, an optical transmitter in the form of an electro-optic conversion unit for each of said plurality of antenna units, each electro-optic conversion unit adapted for converting an RF signal into an optical signal, a plurality of a single core optical fibers for guiding the optical signals, and at least one first space division multiplexing (SDM) unit adapted for multiplexing said single core optical fibers into respective individual cores of a multicore fiber, or into respective individual modes of a multimode fiber.
H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
H04B 10/2575 - Radio-over-fibre, e.g. radio frequency signal modulated onto an optical carrier
44.
GEL FORMULATIONS FOR ENHANCING THE EFFECT OF RADIOTHERAPY
The present invention relates to a composition comprising: a. non-water soluble carbohydrates b. a contrast agent for imaging, wherein at least 60% of the contrast agent remains within 10 cm from the injection site after 24h, for use in local co-administration into a human or animal body, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
A61K 31/522 - Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
The present invention relates to a composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration, for use as a medicament.
The present invention relates to a composition for use as controlled release of at least one active pharmaceutical ingredient that modulates an immunogenic response in a human or animal body, said composition comprising non-water soluble carbohydrates and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration.
The present invention relates to an all-optical pressure sensor comprising a waveguide accommodating a distributed Bragg reflector. Pressure sensing can then be provided by utilizing effective index modulation of the waveguide and detection of a wavelength shift of light reflected from the Bragg reflector. Sound sensing may also be provided thereby having an all-optical microphone. One embodiment of the invention relates to an optical pressure sensor comprising at least one outer membrane and a waveguide, the waveguide comprising at least one core for confining and guiding light, at least one distributed Bragg reflector located in said at least one core, and at least one inner deflecting element forming at least a part of the core, wherein the pressure sensor is configured such that the geometry and/or dimension of the at least one core is changed when the at least one outer membrane is submitted to pressure.
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 23/16 - Devices or apparatus for measuring or indicating or recording rapid changes, such as oscillations, in the pressure of steam, gas, or liquidIndicators for determining work or energy of steam, internal-combustion, or other fluid-pressure engines from the condition of the working fluid operated electrically by photoelectric means
H04R 23/00 - Transducers other than those covered by groups
The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.
The present disclosure relates to a cooling system comprising an active magnetic regenerator having a cold side and a hot side, a hot side heat exchanger connected to the hot side of the magnetic regenerator, one or more cold side heat exchangers, and a cold store reservoir comprising a volume of heat transfer fluid and connected between said one or more cold side heat exchangers and the cold side of the magnetic regenerator, wherein the cooling system is configured to provide a first flow cycle of said heat transfer fluid between the cold store reservoir, the magnetic regenerator and the hot side heat exchanger adapted to transfer thermal energy from the cold store reservoir to the hot side heat exchanger, and at least a second flow cycle of said heat transfer fluid between the cold store reservoir and said one or more cold side heat exchangers adapted to transfer thermal energy from said one or more cold side heat exchangers to the cold store reservoir.
The present invention relates to an all-optical sensor utilizing effective index modulation of a waveguide and detection of a wavelength shift of reflected light and a force sensing system accommodating said optical sensor. One embodiment of the invention relates to a sensor system comprising at least one multimode light source, one or more optical sensors comprising a multimode sensor optical waveguide accommodating a distributed Bragg reflector, at least one transmitting optical waveguide for guiding light from said at least one light source to said one or more multimode sensor optical waveguides, a detector for measuring light reflected from said Bragg reflector in said one or more multimode sensor optical waveguides, and a data processor adapted for analyzing variations in the Bragg wavelength of at least one higher order mode of the reflected light.
G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
G01L 11/02 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group or by optical means
G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
51.
WAVEGUIDE VOLUME PROBE FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY
The present disclosure relates to a probe for use within the field of nuclear magnetic resonance, such as magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS)). One embodiment relates to an RF probe for magnetic resonance imaging and/or spectroscopy comprising a conductive non-magnetic hollow waveguide having an internal volume and at least one open end, one or more capacitors and at least a first conductive non-magnetic wire, wherein said first conductive wire connects at least one of said one or more capacitors to opposite walls of one open end of the waveguide and wherein said first conductive wire and said one or more capacitors are located outside of said internal volume, wherein the internal volume of the hollow waveguide defines an imaging volume or sample volume.
The invention regards a flow meter for ultrasonically measuring the flow velocity of fluids comprising a duct having a flow channel with an internal cross section comprising variation configured to generate at least one acoustic resonance within the flow channel for a specific ultrasonic frequency, and at least two transducers for generating and sensing ultrasonic pulses, configured to transmit ultrasonic pulses at least at said specific ultrasonic frequency into the flow channel such that the ultrasonic pulses propagate through a fluid flowing in the flow channel, wherein the flow meter is configured to determine the flow velocity of the fluid flowing in the flow channel based on a change in transit time, phase and/or pulse such as amplitude and/or form, of the ultrasonic pulses.
G01F 1/66 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters
The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method for editing nucleic acids and a cell comprising a stably integrated endonuclease.
The present invention relates to a novel process for separation of heavy metals from a suspension comprising heavy metal containing particulate material, in which process the heavy metals are removed by use of the electrodialytic remediation set-up. The novel process of the present invention may also be used for recovery of phosphorous in cases where the particulate material also comprises phosphorous in addition to heavy metals. The present invention also relates to the electrochemical cell for use in performing the novel process and to the use of the novel process for separation of heavy metals from the heavy metal containing particulate material.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
The present invention provides a method for developing predictive models of ion channel inhibition by use of a training set of compounds selected from acidic and/or zwitterionic compounds, methods for predicting of ion channel inhibition of compounds selected from acidic and/or zwitterionic compounds, and computer-assisted methods of the above. More specifically the present invention relates to methods for prediction of h ERG inhibition, which is particularly useful for the screening of drugs for cardiac toxicity.
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
The present disclosure relates to system applications of multicore optical fibers. One embodiment relates to a base transceiver station for a wireless telecommunication system comprising a plurality of antenna units arranged in a MIMO configuration and adapted for transmission and/or reception of radio-frequency signals, an optical transmitter in the form of an electro-optic conversion unit for each of said plurality of antenna units, each electro-optic conversion unit adapted for converting an RF signal into an optical signal, a plurality of a single core optical fibers for guiding the optical signals, and at least one first space division multiplexing (SDM) unit adapted for multiplexing said single core optical fibers into respective individual cores of a multicore fiber, or into respective individual modes of a multimode fiber.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
The present invention relates to a novel non-platinum metal catalyst material for use in low temperature fuel cells and electrolysers and to fuel cells and electrolysers comprising the novel non-platinum metal catalyst material. The present invention also relates to a novel method for synthesizing the novel non-platinum metal catalyst material.
A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione- dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
The present invention relates to the field of filtering, more precisely the present invention concerns an apparatus and a method for the separation of dry matter from a medium and the use of said apparatus. One embodiment discloses an apparatus for the separation of dry matter from a medium, comprising a pressure regulated separation chamber defined, in cross section, by a plurality of rollers mounted between opposing sidewalls, each of said rollers having a shaft adapted to be engaged with the sidewalls, a filter arranged so that it passes between at least one set of said rollers consisting of a pore roller and one other roller, means for establishing a pressure difference across the filter, means for passing filter and filter cake through the set of rollers, and a closure mechanism configured to control the transverse tension between the rollers.
B01D 33/044 - Filters with filtering elements which move during the filtering operation with filtering bands or the like supported on cylinders which are pervious for filtering
B01D 33/073 - Filters with filtering elements which move during the filtering operation with rotary cylindrical filtering surfaces, e.g. hollow drums arranged for inward flow filtration
B01D 33/37 - Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in parallel connection
B01D 33/64 - Handling the filter cake in the filter for purposes other than for regenerating for drying by compression
The present invention relates to an all-optical pressure sensor comprising a waveguide accommodating a distributed Bragg reflector. Pressure sensing can then be provided by utilizing effective index modulation of the waveguide and detection of a wavelength shift of light reflected from the Bragg reflector. Sound sensing may also be provided thereby having an all-optical microphone. One embodiment of the invention relates to an optical pressure sensor comprising at least one outer membrane and a waveguide, the waveguide comprising at least one core for confining and guiding light,at least one distributed Bragg reflector located in said at least one core, and at least one inner deflecting element forming at least a part of the core,wherein the pressure sensor is configured such that the geometry and/or dimension of the at least one core is changed when the at least one outer membrane is submitted to pressure.
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
G01L 23/16 - Devices or apparatus for measuring or indicating or recording rapid changes, such as oscillations, in the pressure of steam, gas, or liquidIndicators for determining work or energy of steam, internal-combustion, or other fluid-pressure engines from the condition of the working fluid operated electrically by photoelectric means
The present invention provides methods of upgrading of a CO2-containing fuel gas comprising the use of anaerobic succinic acid-producing microorganisms. Thus, the present invention provides a method for simultaneous upgrading of a CO2-containing fuel gas and biosuccinic acid production.
The invention provides a magnetocaloric heat pump device, comprising a magnetocaloric bed; a magnetic field source, the magnetocaloric bed and the magnetic field source being arranged to move relative to each other so as to generate a magnetocaloric refrigeration cycle within the heat pump, wherein the magnetic field source includes both a permanent magnet and an electromagnet.
The present invention relates to a novel alloy catalyst material for use in the synthesis of hydrogen peroxide from oxygen and hydrogen, or from oxygen and water. The present invention also relates to a cathode and an electrochemical cell comprising the novel catalyst material, and the process use of the novel catalyst material for synthesising hydrogen peroxide from oxygen and hydrogen, or from oxygen and water.
The present invention provides assays, methods and systems for selecting an effective therapy for a subset of cancer patients having cancer cells with increased expression of BML and FANCI genes and/or having copy number increase in chromosome location 15q26 in the cancer cells and for treatment of such patients with the effective therapy of cancer patients based on the personalized cancer cell expression profile.
In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature, a chirp in the local spatial frequency of interference fringes of an interference pattern is reduced by mathematical manipulation of the recorded light intensity in the interference pattern or by the physical positioning and arrangement of a detector used for capturing the interference pattern.
In a method for performing a refractive index based measurement of a property of a fluid such as chemical composition or temperature by observing an apparent angular shift in an interference fringe pattern produced by back or forward scattering interferometry, ambiguities in the measurement caused by the apparent shift being consistent with one of a number of numerical possibilities for the real shift which differ by 2n are resolved by combining measurements performed on the same sample using light paths therethrough of differing lengths.
A refractive index based measurement of a property of a fluid is measured in an apparatus comprising a variable wavelength coherent light source (16), a sample chamber (12), a wavelength controller (24), a light sensor (20), a data recorder (26) and a computation apparatus (28), by - directing coherent light having a wavelength along an input light path, - producing scattering of said light from each of a plurality of interfaces within said apparatus including interfaces between said fluid and a surface bounding said fluid, said scattering producing an interference pattern formed by said scattered light, - cyclically varying the wavelength of said light in said input light path over a 1 nm to 20nm wide range of wavelengths a rate of from 10Hz to 50 KHz, - recording variation of intensity of the interfering light with change in wavelength of the light at an angle of observation, and - calculating a said property from said variation.
The present invention relates to a filtering apparatus and method for mixing a compound of solid and fluid phases, separating the phases and/or extracting fluid from the compound. One embodiment of the invention discloses a filtering apparatus comprising a first filter section accommodating a first group of filter members, and a second filter section accommodating a second group of filter members, a piping system providing pipelined fluid communication between the filter sections and between a filter section and said filter section's corresponding group of filter members, the piping system configured such that the filter members form filtered fluid openings of the filtering apparatus, and circulation means, such as a pump, configured for passing fluid in a forward flow and/or in a reverse flow between the filter sections. In particular the invention may be used for the mashing process in a beer brewing procedure.
B01D 33/37 - Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in parallel connection
B01D 33/41 - Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in series connection
B01D 33/35 - Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition
B01D 29/50 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition
B01D 29/52 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in parallel connection
B01D 29/56 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in series connection
C12C 11/11 - Post fermentation treatments, e.g. carbonation or concentration
C12C 7/165 - Lautering, i.e. clarifying wort by straining in mash filters
B01D 33/073 - Filters with filtering elements which move during the filtering operation with rotary cylindrical filtering surfaces, e.g. hollow drums arranged for inward flow filtration
B01D 33/11 - Filters with filtering elements which move during the filtering operation with rotary cylindrical filtering surfaces, e.g. hollow drums arranged for outward flow filtration
B01D 29/11 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with bag, cage, hose, tube, sleeve or like filtering elements
B01D 29/15 - Supported filter elements arranged for inward flow filtration
B01D 29/23 - Supported filter elements arranged for outward flow filtration
71.
DATABASE-DRIVEN PRIMARY ANALYSIS OF RAW SEQUENCING DATA
The present invention relates to methods for identifying the source of a biological sequence containing sample from raw sequencing reads. The method may be used to identify the source of unknown DNA and can be used for diagnostic, biodefense, food safety and quality, and hygiene applications. In another aspect the invention relates to a database of reference sequences which can be used in the method of the invention.
G06F 19/22 - for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or Single-Nucleotide Polymorphism [SNP] discovery or sequence alignment
A genetically modified Saccharomyces cerevisiae comprising an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
A method of conducting radiofluorination of a substrate, comprising the steps of: (a) contacting an aqueous solution of [18F] fluoride with a polymer supported phosphazene base for sufficient time for trapping of [18F] fluoride on the polymer supported phosphazene base; and (b) contacting a solution of the substrate with the polymer supported phosphazene base having [18F] fluoride trapped thereon obtained in step (a) for sufficient time for a radiofluorination reaction to take place; an apparatus for conducting radiofluorination; use of the apparatus; and an apparatus for production of a dose of a radiotracer for administration to a patient.
C07B 59/00 - Introduction of isotopes of elements into organic compounds
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
74.
SOLID OXIDE CELL OXYGEN ELECTRODE WITH ENHANCED DURABILITY
The present invention provides various methods of producing a solid oxide cell with an enhanced durability. Dopants are provided at the interface of the electrode comprising LSM and electrolyte and prevent especially the diffusion of Mn from the electrode layer into the electrolyte, stabilizing the LSM and thereby preventing the formation of unwanted degradation products.
IBC - DEPARTMENT OF INTERNATIONAL BUSINESS COMMUNICATION (Denmark)
TECHNICAL UNIVERSITY OF DENMARK (Denmark)
Inventor
Glückstad, Fumiko Kano
Mørup, Morten
Herlau, Tue
Schmidt, Mikkei, N.
Abstract
The present invention relates to a method, computer program and system for inferring relations between cultural specific concepts (CSC) in two cultures at least comprising the steps of - extracting and listing said cultural specific concepts (CSCs) and features of said CSCs from at least a first corpora belonging to a first culture and a second corpora belonging to a second culture, - applying a algorithm to infer relations between said CSCs in the first and the second corpora.
The present invention relates to a system and a method for detection of abnormal motor activity during REM sleep, and further to systems and method for assisting in detecting neurodegenerative disorders such as Parkinson's. One embodiment relates to a method for detection of abnormal motor activity during REM sleep comprising the steps of: performing polysomnographic recordings of a sleeping subject, thereby obtaining one or more electromyography (EMG) derivations, preferably surface EMG recordings, and one or more EEG derivations, and/or one or more electrooculargraphy (EOG) derivations, detecting one or more REM sleep stages, preferably based on the one or more EEG and/or EOG derivations, determining the level of muscle activity during the one or more REM sleep stages based on the one or more EMG derivations, wherein a subject having an increased level of muscle activity during REM sleep compared to one or more normal subjects has abnormal motor activity during REM sleep.
The present invention relates to an all-optical sensor utilizing effective index modulation of a waveguide and detection of a wavelength shift of reflected light and a force sensing system accommodating said optical sensor. One embodiment of the invention relates to a sensor system comprising at least one multimode light source, one or more optical sensors comprising a multimode sensor optical waveguide accommodating a distributed Bragg reflector, at least one transmitting optical waveguide for guiding light from said at least one light source to said one or more multimode sensor optical waveguides, a detector for measuring light reflected from said Bragg reflector in said one or more multimode sensor optical waveguides, and a data processor adapted for analyzing variations in the Bragg wavelength of at least one higher order mode of the reflected light.
G01L 11/02 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group or by optical means
G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
The present invention concerns a novel internal reference electrode as well as a novel sensing electrode for an improved internal reference oxygen sensor and the sensor employing same.
The present invention relates to methods for predicting response of a cancer in a subject to anti-cancer therapies based upon a determination and analysis of a chromosomal aberration score, such as the number of allelic imbalance or the number of telomeric allelic imbalance in the chromosomes of the human genome.
The present invention relates to methods for predicting response of a cancer in a subject to anti-cancer therapies based upon a determination and analysis of a chromosomal aberration score, such as the number of allelic imbalance or the number of telomeric allelic imbalance in the chromosomes of the human genome.
A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
The present invention relates to methods for predicting response of a cancer in a subject to anti-cancer therapies based upon a determination and analysis of a chromosomal aberration score, such as the number of allelic imbalance or the number of telomeric allelic imbalance in the chromosomes of the human genome.
The present disclosure relates to an illumination system for endoscopic applications comprising at least one substantially monochromatic light source having a predefined central wavelength between 400 and 500 nm or between 500 and 550 nm, an optical transmission path adapted to guide light emanating from the light source to an endoscopic region of examination, and an optical band-rejection filter, wherein the illumination system is adapted to illuminate at least a part of the region of examination by generating autofluorescence in surrounding tissue, and the band-rejection filter is adapted to attenuate at least said light source wavelength to a viewer and wherein said light source is the single light source in the illumination system. A further embodiment relates to an endoscope for examining a body cavity comprising tissue, the endoscope comprising a source of light consisting of a substantially monochromatic light source having a predefined central wavelength between 400 and 550 nm, means for guiding light from the substantially monochromatic light source towards at least a part of the tissue, and at least one band-rejection filter adapted to attenuate at least said central wavelength, wherein the substantially monochromatic light source is configured to generate autofluorescence in the irradiated tissue such that the irradiated tissue is observable, and wherein the endoscope is configured to display at least a part of the irradiated tissue through said band-rejection filter. A system for photodynamic diagnosis and/or therapy of bladder cancer is further disclosed herein.
A61B 1/307 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
84.
A MODIFIED ANODE/ELECTROLYTE STRUCTURE FOR A SOLID OXIDE ELECTROCHEMICAL CELL AND A METHOD FOR MAKING SAID STRUCTURE
A novel modified anode/electrolyte structure for a solid oxide electrochemical cell is an assembly comprising (a) an anode consisting of a backbone of electronically conductive perovskite oxides selected from the group of doped strontium titanates and mixtures thereof, (b) a scandia and yttria-stabilised zirconium oxide electrolyte and (c) a metallic and/or a ceramic electrocatalyst in the shape of interlayers incorporated in the interface between the anode and the electrolyte. This assembly is first sintered at a given temperature and then at a lower temperature in reducing gas mixtures. These heat treatments resulted in a distribution of the metallic and/or ceramic interlayers in the electrolyte/anode backbone junction taking place. The structure is prepared by (a) depositing a ceramic interlayer onto one side of the electrolyte, (b) optionally applying a metallic interlayer thereon, (c) repeating steps (a) and (b), (d) applying a layer of the selected anode backbone onto the electrolyte with applied interlayers, (e) sintering the raw assembly and (f) infiltrating the electrocatalyst precursor into the sintered assembly and heat treating the assembly to incorporate additional electrocatalyst into the anode backbone.
C04B 35/00 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
85.
METHODS AND APPARATUS FOR HYDROGEN BASED BIOGAS UPGRADING
The present invention relates to an anaerobic process for biogas upgrading and hydrogen utilization comprising the use of acidic waste as co-substrate.In this process,H2 and CO2 will be converted to CH4, which will result in lower CO2 content in the biogas. The invention relates to both in situ and ex situ methods of biogas upgrading. The invention further relates to a bioreactor comprising hollow fibre membranes.
A high performance anode (fuel electrode) for use in a solid oxide electrochemical cell is obtained by a process comprising the steps of (a) providing a suitably doped, stabilized zirconium oxide electrolyte, such as YSZ,ScYSZ, with an anode side having a coating of electronically conductive perovskite oxides selected from the group consisting of niobium-doped strontium titanate, vanadium-doped strontium titanate, tantalum-doped strontium titanate and mixtures thereof, thereby obtaining a porous anode backbone, (b) sintering the coated electrolyte at a high temperature, such as 1200°C in a reducing atmosphere, for a sufficient period of time, (c) effecting a precursor infiltration of a mixed catalyst into the backbone, said catalyst comprising a combination of noble metals Pd or Pt or Pd or Ru and Ni with rare earth metals, such as Ce or Gd, said infiltration consisting of (1) infiltration of Pd, Ru and CGO containing chloride/nitrate precursors and (2) infiltration of Ni and CGO containing nitrate precursors, and (d) subjecting the resulting structure of step (c) to heat treatments, including heat treatments in several steps with infiltration.
C04B 35/00 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
87.
METHOD AND SYSTEM FOR PURIFICATION OF GAS/LIQUID STREAMS FOR FUEL CELLS OR ELECTROLYSIS CELLS
The present invention provides in embodiments a method for purification of inlet gas/liquid streams in a fuel cell or electrolysis cell, the fuel cell or electrolysis cell comprising at least a first electrode, an electrolyte and a second electrode, the method comprising the steps of: - providing at least one scrubber in the gas/liquid stream at the inlet side of the first electrode of the fuel cell or electrolysis cell; and/or providing at least one scrubber in the gas/liquid stream at the inlet side of the second electrode of the fuel cell or electrolysis cell; and - purifying the gas/liquid streams towards the first and second electrode; wherein the at least one scrubber in the gas/liquid stream at the inlet side of the first electrode and/or the at least one scrubber in the gas/liquid stream at the inlet side of the second electrode comprises a material suitable as an electrolyte material and a material suitable as an electrode material, and wherein the material suitable as an electrolyte material and a material suitable as an electrode material form triple phase boundaries similar to or identical to the triple phase boundaries of the electrode for which the gas/liquid stream is purified with the at least one scrubber, with the proviso that the fuel cell or electrolysis cell is not a solid oxide cell.
H01M 8/06 - Combination of fuel cells with means for production of reactants or for treatment of residues
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
88.
FILTERING APPARATUS AND METHOD FOR MIXING, EXTRACTION AND/OR SEPARATION
The present invention relates to a filtering apparatus and method for mixing a compound of solid and fluid phases, separating the phases and/or extracting fluid from the compound. One embodiment of the invention discloses a filtering apparatus comprising a first filter section accommodating a first group of filter members, and a second filter section accommodating a second group of filter members,a piping system providing pipelined fluid communication between the filter sections and between a filter section and said filter section's corresponding group of filter members, the piping system configured such that the filter members form filtered fluid openings of the filtering apparatus, and circulation means, such as a pump, configured for passing fluid in a forward flow and/or in a reverse flow between the filter sections. In particular the invention may be used for the mashing process in a beer brewing procedure.
B01D 33/15 - Filters with filtering elements which move during the filtering operation with rotary plane filtering surfaces
B01D 33/37 - Filters with filtering elements which move during the filtering operation with multiple filtering elements characterised by their mutual disposition in parallel connection
B01F 7/00 - Mixers with rotary stirring devices in fixed receptacles; Kneaders
B01D 29/11 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with bag, cage, hose, tube, sleeve or like filtering elements
B01D 29/52 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in parallel connection
B01D 29/70 - Regenerating the filter material in the filter by forces created by movement of the filter element
B01D 29/94 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor having feed or discharge devices for discharging the filter cake, e.g. chutes
The present invention relates to liquid filled light distributor comprising an elongated tubular body with a tube wall defining an in inner lumen filled with a liquid, said tubular body having -a proximal end closed by first closing means -a distal end closed by second closing means. Wherein the proximal end is arranged to be in optical communication with a light source and wherein the refractive index of the tube wall is n1 and the refractive index of the fluid is n2 and n1/n2 <1 so that light from the light source travels along the longitudinal direction of the tubular body and that a part of the light is emitted through the tube wall along at least a part of the tubular body. Further a method of use for the liquid filled light distributor is provided.
The present invention relates to a flange for sampling a liquid flow from a substantially vertical liquid flow path comprising a trench located on the flange rim and adapted for collecting and/or housing a liquid sample and a channel for collecting or extracting said liquid sample, said channel extending transversely through at least a part of the side of the flange in liquid communication with said trench.
The present invention concerns a structure useful for producing a thermoelectric generator, a thermoelectric generator comprising same and a method for producing same. A method for producing a structure useful for producing a thermoelectric generator, wherein the structure comprises at least one stripe of a n-type and at least one stripe of a p-type material, either separated by a stripe of an insulating material, or provided spatially separated on an insulating material, and comprising stripes of conductive material each connecting one n-type stripe with one p-type stripe, and not in electrical contact with each other, wherein the structure is free from polymeric substrates, wherein the method comprises the steps of co-forming the at least one stripe of a n-type and at least one stripe of a p-type material in a single manufacturing step; and forming connections between the at least one stripe of a n-type and at least one stripe of a p- type material by means of stripes of conductive material. The structure useful for producing a thermoelectric generator is obtainable by the above method. The thermoelectric generator comprises at least one such structure.
H01L 35/22 - Selection of the material for the legs of the junction using inorganic compositions comprising compounds containing boron, carbon, oxygen, or nitrogen
H01L 35/32 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the structure or configuration of the cell or thermocouple forming the device
H01L 35/34 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof
92.
SINTERING ADDITIVES FOR CERAMIC DEVICES OBTAINABLE IN A LOW pO2 ATMOSPHERE
The present invention provides a method for producing a ceramic device in a low pO2 atmosphere, comprising the steps of: - providing a composition comprising a base material and a transition metal; wherein the base material for the first layer is selected from the group consisting of zirconate, cerate, titanate, lanthanate, aluminate, doped zirconia and/or doped ceria, wherein the dopants are selected from the group of Ca, Ga, Sc, Y, and lanthanide elements; - forming a first layer of said composition, wherein said first layer is an electrolyte layer; - forming at least one electrode layer or electrode precursor layer on one side or both sides of said first layer; and - sintering the multilayer structure in a low p02 atmosphere; characterized in that: the amount of the transition metal is from 0.01 to 4 mol%, based on the composition of the first layer; the oxygen partial pressure p02 is 10"14 Pa or less; and the sintering temperature is in the range of from 700 to 1600°C.
C04B 35/462 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates based on titanates
C04B 35/50 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on rare earth compounds
C04B 35/44 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on aluminates
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
TECHNICAL UNIVERSITY OF DENMARK (Denmark)
Inventor
Studt, Felix
Abild-Pedersen, Frank
Norskov, Jens
Dahl, Soren
Sharafutdinov, Irek
Elkjaer, Christian
Abstract
A catalytic composition is provided for methanol production. The composition includes an alloy of at least two different metals M and M', where M is selected from Ni, Pd, Ir, and Ru, and M' is selected from Ga, Zn, and Al. A molar ratio of M to M' is in the range of 1:10 to 10:1, and the alloy is configured to catalyze a reduction of CO2 to methanol.
A photovoltaic cell module comprising at least two serially connected photovoltaic cells on a common substrate, wherein the cells each comprise a first electrode layer, a first charge selective layer, a light harvesting layer which comprises an organic conjugated polymer, and a second charge selective layer that selects for an opposite charge to the first charge selective layer, wherein the first electrode layers for each cell are formed such that the first electrode layer of one cell has no direct electrical connection to the first electrode layer of any other cell, and the second charge selective layer is formed such that the second charge selective layer of one cell has no direct electrical connection to the second charge selective layer of any other cell, and wherein the light-harvesting layer is formed such that it is common to at least one pair of adjacent cells of the module; wherein, for the at least one pair of adjacent cells to which the light harvesting layer is common, a metal layer is formed such that an electrical connection is established between the second charge selective layer of a first one of the at least one pair of adjacent cells and the first electrode layer of a second cell of the pair, which connection is made through the light harvesting layer common to the at least one pair of cells, without forming an electrical connection with the first electrode of the first cell or the second charge selective layer of the second cell; and a method of making such a photovoltaic cell module.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 27/30 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including components using organic materials as the active part, or using a combination of organic materials with other materials as the active part with components specially adapted for either the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
A container assembly for the containment of fluids or solids under a pressure different from the ambient pressure comprising a container (2) comprising an opening and an annular sealing, a lid (3) comprising a central portion (5) and engagement means (7) for engaging the annular flange, and sealing means (10) wherein the engagement means (7) is adapted, via the sealing means, to seal the opening when the pressure of the container assembly differs from the ambient pressure in such a way that the central portion (5) flexes in the axial direction which leads to a radial tightening of the engagement means (7) to the container, wherein the container further comprises locking means (12) that can be positioned so that the central portion is hindered from flexing in at least one direction.
The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides,for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
97.
SOLID OXIDE CELL STACK AND METHOD FOR PREPARING SAME
A method for producing and reactivating a solid oxide cell stack structure by providing a catalyst precursor in at least one of the electrode layers by impregnation and subsequent drying after the stack has been assembled and initiated. Due to a significantly improved performance and an unexpected voltage improvement this solid oxide cell stack structure is particularly suitable for use in solid oxide fuel cell (SOFC) and solid oxide electrolysing cell (SOEC) applications.
The present invention relates to a novel anaerobic, extreme thermophilic, ethanol high- yielding bacterium. The invention is based on the isolation of the bacterial strain referred to herein as "DTU01", which produces ethanol as the main fermentation product, followed by acetate and lactate. The isolated organism is an extremely interesting and very promising organism for the establishment of a sustainable bioethanol production process. The invention further relates to a method for producing a fermentation product such as ethanol.
The present invention relates to methods for diagnosing transplant rejection, or a condition associated with transplant rejection, such as, primary graft dysfunction in a subject, to antigen probe arrays for performing such a diagnosis, and to antigen probe sets for generating such arrays.
The present invention provides: a method of preparing a coating ink for forming a zinc oxide electron transport layer, comprising mixing zinc acetate and a wetting agent in water or methanol; a coating ink comprising zinc acetate and a wetting agent in aqueous solution or methanolic solution; a method of preparing a zinc oxide electron transporting layer, which method comprises: i) coating a substrate with the coating ink of the present invention to form a film; ii) drying the film; and iii) heating the dry film to convert the zinc acetate substantially to ZnO; a method of preparing an organic photovoltaic device or an organic LED having a zinc oxide electron transport layer, the method comprising, in this order: a) providing a substrate bearing a first electrode layer; b) forming an electron transport layer according to the following method: i) coating a coating ink comprising an ink according to the present invention to form a film; ii) drying the film; iii) heating the dry film such that the zinc acetate is substantially converted to ZnO; c) forming an active layer; d) forming a hole transport layer; and e) forming a second electrode layer; and an optoelectronic device comprising an electron transporting layer comprising zinc oxide and a wetting agent.
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