Abstract

The invention, provides a method and a device for delivery of foam to a target site of a respiratory system of a subject.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/12 - AerosolsFoams
• A61K 35/42 - Respiratory system, e.g. lungs, bronchi or lung cells
• A61M 13/00 - Insufflators for therapeutic or disinfectant purposes
• A61M 16/10 - Preparation of respiratory gases or vapours
• A61M 16/14 - Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Abstract

A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.

IPC Classes  ?

• C12N 1/14 - Fungi Culture media therefor
• C08L 1/04 - OxycelluloseHydrocellulose

Abstract

The present invention provides cyclic peptides, as well as methods of using the same, such as for ameliorating or treating a K63Ub-related disease in a subject in need thereof.

IPC Classes  ?

• A61K 38/12 - Cyclic peptides
• C07K 7/64 - Cyclic peptides containing only normal peptide links

Abstract

A method for quantitative magnetic resonance imaging (MRI), the method includes (a) receiving a sequence of MRI images of an in vivo tissue, by an image registration deep neural network (DNN) module that was trained, by a training process, to impose one or more MRI signal related physical constraints on a content of the sequence of MRI images; and (b) extracting one or more quantitative map from the sequence of MRI images.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

This invention relates to a device comprising polyethylene sulfone (PES) and additional suitable polymers with high load of Prussian blue analogue nanoparticles for removal of monovalent or divalent cation contaminants, optionally doped, and process for the preparation and methods for use thereof. The device and method relate to selectively and effectively remove ammoniacal nitrogen removal and recovery as a valuable resource, and removing radioactive cesium and/or other monovalent or divalent cations from contaminated water.

IPC Classes  ?

• B01D 69/14 - Dynamic membranes
• B01D 65/02 - Membrane cleaning or sterilisation
• B01D 71/02 - Inorganic material
• C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
• C02F 101/10 - Inorganic compounds

Abstract

A system and a method of fabricating an article are disclosed. The method comprises: providing an immersion liquid to at least one first portion and at least one second portion of a chamber divided by a divider; opening a valve between the at least one first and at least one second portions; providing a curable liquid to an article frame included in the divider; closing the valve; adjusting a volume or pressure of the immersion liquid in the at least one first portion using a pump, to control a curvature of the article; and curing the curable liquid to form the article.

IPC Classes  ?

• B29D 11/00 - Producing optical elements, e.g. lenses or prisms
• B29C 41/50 - Shaping under special conditions, e.g. vacuum

Abstract

The present invention is directed to compositions comprising the Ag2S quantum dots of the invention and to methods for use thereof, such as for the treatment and/or prevention a cell or tissue damage and/or a disease or condition in a subject associated therewith. Further, pharmaceutical or cosmetic compositions comprising Ag2S quantum dots of the invention, and articles (e.g. cosmetic/medical article) comprising same are also provided.

IPC Classes  ?

• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• C07F 1/10 - Silver compounds
• A61K 9/14 - Particulate form, e.g. powders
• A61K 8/36 - Carboxylic acidsSalts or anhydrides thereof
• A61K 33/38 - SilverCompounds thereof
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/08 - Measuring devices for evaluating the respiratory organs
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/113 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The present invention provides a system for direct protein-protein interaction between a first cell and a second cell, including: (a) a first cell including a first polynucleotide sequence encoding a first synthetic polypeptide being a membrane anchored ligand including an extracellular portion being a ligand domain and a first membrane anchoring domain; and (b) a second cell including: (i) a second polynucleotide sequence encoding a second synthetic polypeptide being a receptor including an extracellular portion being a binding domain having specific binding affinity to the ligand of (a), a second membrane anchoring domain, and an intracellular portion including a transcription factor; and (ii) a third polynucleotide sequence encoding a gene of interest. Further provided are methods of using the system, and a kit for preparing same.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

The present invention relates generally to the technological field of computer-aided design and modeling. In the general aspect, the invention may be directed to a method of federated computer-aided modeling of an object, by at least one processor, the method including: obtaining a plurality of sub-models, complementary representing the object, wherein each sub-model consists of one or more structural elements defined by parameters thereof; for each sub-model, generating a sub-graph representation, having said structural elements and parameters thereof represented as semantic triples; analyzing said semantic triples taken from different sub-graph representations to detect interrelations therebetween; instantiating semantic connections between the generated sub-graph representations, based on detected interrelations, thereby obtaining a meta-graph representation of a model of the object; and developing the model of the object, based on the obtained meta-graph representation.

IPC Classes  ?

• G06F 30/13 - Architectural design, e.g. computer-aided architectural design [CAAD] related to design of buildings, bridges, landscapes, production plants or roads
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

Methods of predicting clinical outcome in a subject suffering from cancer, detecting non-liver cancer in a subject, and methods of treating or preventing cancer or cancer-associated cachexia are provided. Synthetic lipid nanoparticles encapsulating an mRNA encoding for HNF4A and composition comprising same are also provided.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 35/00 - Antineoplastic agents
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons

Abstract

Mechanophoric compounds featuring one or more, or two or more, clickable group(s), which are capable of being coupled to naturally occurring, synthetic and/or metallic substrates via Click chemistry, method of preparing mechanophoric matrices using the mechanophoric compounds, and mechanophoric matrices obtainable thereby, and uses thereof for detecting force-induced damage in the matrices by a colorimetric change are provided.

IPC Classes  ?

• C07D 491/107 - Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

Nucleic acid molecules configured to constitutively express a sequence of interest in a eukaryotic cell comprising a transcription factor binding region, a core promoter and a sequence of interest operatively linked to the transcription factor binding region and core promoter are provided. Methods of constitutively expressing a sequence of interest in a eukaryotic cell are also provided.

IPC Classes  ?

• C12N 15/67 - General methods for enhancing the expression
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

An X-ray generator is presented comprising: an electron source generating an accelerated electron beam propagating along a first propagation path with a first general propagation direction; a first crystalline structure located in the first propagation path, and defining a first crystal plane oriented at a predetermined non-zero angle with the first propagation path, and configured to transmit the electron beam therethrough and generate parametric x-ray (PXR) emission being first directional emission along a second propagation path tilted with respect to the first general propagation direction; and a second crystalline structure located in the second propagation path and configured as a monochromator with respect to the PXR emission, and defining a second crystal plane oriented at the predetermined non-zero angle with respect to the second propagation path to thereby provide second directionality for the PXR emission.

IPC Classes  ?

• H05G 2/00 - Apparatus or processes specially adapted for producing X-rays, not involving X-ray tubes, e.g. involving generation of a plasma

Abstract

The present invention relates to a method and system for monitoring cardiac functions and quantifying objective, operator-independent indices of cardiac functions. The invention quantifies both ventricle cavity and wall dynamics. It provides a picture with a comprehensive view of the six phases of cardiac contraction, relaxation and filling (isovolumic contraction, ejection, isovolumic relaxation, rapid filling, diastasis and atrial kick). It enables to quantify the effect of respiration and mechanical ventilation on cardiac chamber loadings and thereby to optimize mechanical ventilation in the general and cardiac intensive care units. It enables to assess the phase differences between the electrical activations and mechanical contractions of the various chambers and thus to adjust and optimize the parameters of cardiac synchronization therapies of ventricle chambers and chamber walls (as cardiac resynchronization therapy).

IPC Classes  ?

• A61B 8/08 - Clinical applications
• G06T 7/11 - Region-based segmentation
• A61B 8/06 - Measuring blood flow

Abstract

The invention relates generally to the field of compositions including one or more conjugates of di-sugar and a nonsteroidal anti-inflammatory drug (NSAID), and use of same in methods for treating a disease or a disorder in a subject in need thereof.

IPC Classes  ?

• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

The present invention relates to systems for identifying one or more ions in a liquid solution, including a solid surface configured to be in contact with the liquid solution; a mechanical wave generator configured to be in contact with the solid surface and/or with the liquid solution; and a working microelectrode configured to be positioned in the liquid solution in close proximity to the solid surface without contacting it. Methods of the invention include generating a mechanical wave which propagates and excites ions of an electrical double layer (EDL) formed at an interface between the solid surface and the liquid solution, thereby causing the EDL to vibrate and to leak an electrical field. The electrode measures electrical potential of the electrical field over time, which yields a voltage spectrum comprising amplitude and phase which are indicative of an identity and a concentration of the one or more ions in the liquid solution.

IPC Classes  ?

• G01N 29/02 - Analysing fluids
• G01N 29/024 - Analysing fluids by measuring propagation velocity or propagation time of acoustic waves
• G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
• G01N 27/66 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber and measuring current or voltage

Abstract

An atomic interferometer system comprises optical tweezers each configured to trap at least one atom therein, an atom source system configured to release atoms, and a controller configured to control the optical tweezers to trap at least one atom released by the atom source system in one of the tweezers, to spatially split a wave function of the trapped atom between at least two of the tweezers, and to at least partially recombine the split atomic wave function in at least one of the tweezers. The atomic interferometer system can also comprise a measuring system configured to measure wavefunction population in each of the tweezers and to display an output pertaining to the wavefunction populations.

IPC Classes  ?

• G01N 15/1434 - Optical arrangements
• G01V 7/02 - Measuring gravitational fields or wavesGravimetric prospecting or detecting Details
• G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
• H03L 7/26 - Automatic control of frequency or phaseSynchronisation using energy levels of molecules, atoms, or subatomic particles as a frequency reference

Abstract

The present invention provides a composition comprising (i) a cellulose-based polymer, and (ii) a plasticizer; wherein a weight per weight (w/w) concentration of the plasticizer within the composition is from 0.1 to 20%; and wherein a glass transition temperature (Tg) of the composition is reduced by at least 20% compared to a Tg of the cellulose-based polymer. Furthermore, provided herein are articles comprising the composition of the invention, and methods for manufacturing thereof.

IPC Classes  ?

• C08L 1/28 - Alkyl ethers
• C08J 5/18 - Manufacture of films or sheets
• C08K 5/053 - Polyhydroxylic alcohols
• C08K 5/103 - EstersEther-esters of monocarboxylic acids with polyalcohols
• C08K 5/11 - EstersEther-esters of acyclic polycarboxylic acids

Abstract

This disclosure relates to methods and compositions useful for detecting and monitoring low-frequency mutations. Methods and compositions described herein can be used to guide clinical decisions, for example, by informing on which antibiotics should be avoided, or conversely, which antibiotics should be actively used in the case of compounds that select against a specific type of resistance.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/6869 - Methods for sequencing

Abstract

Nanostructured electrodes comprising nanoparticles of conductive material deposited on a conductive electrode support are described in the present invention. Said nanoparticles are characterised by a particle size of about 20.0 nm or less and a particle size distribution having a tuneable standard deviation from ±0.1 nm to ±1.0 nm. This particle size distribution is measured using a differential mobility analyser. The nanostructured electrodes are manufactured by the method of spark ablation, which provides a scalable and viable way for producing widely different types of mixed nanoparticles. Most importantly, implementation of the spark ablation has the great advantage to combine a wider range of materials, thereby allowing the synthesis of mixed nanoparticles with virtually unlimited combinations and highly sharp particle size distribution control which is advantageous for high tunability of selectivity.

IPC Classes  ?

• C25B 11/037 - Electrodes made of particles
• B22F 1/054 - Nanosized particles
• B22F 9/14 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes using electric discharge
• C02F 1/46 - Treatment of water, waste water, or sewage by electrochemical methods
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• C02F 1/66 - Treatment of water, waste water, or sewage by neutralisationTreatment of water, waste water, or sewage pH adjustment
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/061 - Metal or alloy
• C25B 11/067 - Inorganic compound e.g. ITO, silica or titania
• C25B 11/089 - Alloys
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25B 13/07 - DiaphragmsSpacing elements characterised by the material based on inorganic materials based on ceramics
• H01M 4/88 - Processes of manufacture
• H01M 4/90 - Selection of catalytic material

Abstract

An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 34/30 - Surgical robots
• A61B 34/35 - Surgical robots for telesurgery
• A61B 34/37 - Leader-follower robots
• A61M 25/00 - CathetersHollow probes
• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/02 - Holding devices, e.g. on the body
• A61M 25/09 - Guide wires
• B25J 9/00 - Programme-controlled manipulators
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

The present invention provides, in some embodiments, a device, kit and method, for detection of a microorganism in a food sample.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/24 - Methods of sampling, or inoculating or spreading a sampleMethods of physically isolating an intact microorganism
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

Disclosed is a method of fabricating a construction element. The method may include assembling a mold on a rotational casting machine; rotating the mold around at least two axes at a predetermined speed; providing a first portion of magnesium silico-phosphate cement (MSPC) mix, having an altered hardening rate, to the mold while rotating the mold until at least a portion of the mold's walls is covered by a first layer of the MSPC mix; and rotating the mold until the MSPC mix is hardened to a predetermined degree.

IPC Classes  ?

• B28B 1/20 - Producing shaped articles from the material by centrifugal or rotational casting
• C04B 20/00 - Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups and characterised by shape or grain distributionTreatment of materials according to more than one of the groups specially adapted to enhance their filling properties in mortars, concrete or artificial stoneExpanding or defibrillating materials
• C04B 28/34 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
• C04B 103/20 - Retarders
• C04B 111/56 - Compositions suited for fabrication of pipes, e.g. by centrifugal casting

Abstract

A hybrid system, including a solid-oxide fuel cell (SOFC), an internal combustion engine (ICE), and a thermochemical recuperation (TCR) unit. The TCR unit is configured to: (i) receive waist heat from the ICE, (ii) receive a primary fuel, (iii) perform a waste heat recovery process to provide reformed fuel. The SOFC is configured to receive a first part of the reformed fuel and convert the first part of the reformed fuel to electrical work. The ICE is configured to receive a second part of the reformed fuel and convert the second part of the reformed fuel to mechanical work.

IPC Classes  ?

• F02B 53/14 - Adaptations of engines for driving, or engine combinations with, other devices
• F02B 53/10 - Fuel supplyIntroducing fuel to combustion space
• H01M 8/04746 - PressureFlow
• H01M 8/12 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte

Abstract

Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

Abstract

The invention generally concerns photo-electrochemical cells for generating electric currents from organic materials.

IPC Classes  ?

• C25B 1/55 - Photoelectrolysis
• C25B 11/04 - ElectrodesManufacture thereof not otherwise provided for characterised by the material
• C25B 3/21 - Photoelectrolysis
• C25B 3/23 - Oxidation
• H01G 9/20 - Light-sensitive devices
• H01L 31/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof

Abstract

12344, derived from proteins forming abnormal aggregates, compositions and uses thereof for treatment of proteinopathies.

IPC Classes  ?

• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 5/10 - Tetrapeptides
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A method of determining fusogenic potential of sperm is provided, The method comprising: (a) contacting a biological sample comprising sperm with somatic cells expressing ectopic JUNO under conditions which allow binding of the sperm to the JUNO; and subsequently (b) detecting multinucleation in the somatic cells, wherein a level of the multinucleation is indicative of the fusogenic potential of the sperm.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 5/16 - Animal cells
• A61D 19/02 - Instruments or methods for reproduction or fertilisation for artificial insemination

Abstract

An isolated multicellular organoid comprising cardiomyocytes, endothelial cells, fibroblasts and smooth muscle cells is disclosed. The endothelial cells form part of a 3D endothelial structure, the cardiomyocytes of the organoid are capable of synchronized contractions, and epicardial cells of the organoid do not form a distinct layer in the organoid. Methods of maturing immature cardiomyocytes and use of cardiomyocytes for generating disease models are also disclosed.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/34 - MusclesSmooth muscle cellsHeartCardiac stem cellsMyoblastsMyocytesCardiomyocytes
• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells

Abstract

The disclosure provides a programmable, battery-less, autonomous and biodegradable smart dust particle (SDP) comprises: (i) a single layer or plurality of layers of a layered separating media for chromatographic separation of compounds contained in a sample subjected to the separation and for providing physical support for embedded electronics and for at least one detector; (ii) said at least one detector comprising an array of sensors printed on the layers of said separating media, and providing information on the presence and properties of said compounds in the sample; (iii) said embedded electronics printed on the layers of said separating media; and (iv) at least one radio-frequency identification (RFID) out-input tag for remote readout and zero-power operation, each RFID tag connected to said embedded electronics via an electric circuit for receiving or transmitting a signal. In addition, two systems comprising a plurality of the SDPs are disclosed: the first for autonomous analysis of an environmental sample and the second for tumour diagnosis. A method for diagnosing tumours and a wearable tomography device using the SDPs are also disclosed.

IPC Classes  ?

• G01N 30/60 - Construction of the column
• G01N 30/90 - Plate chromatography, e.g. thin layer or paper chromatography

Abstract

A device for signal acquisition, comprises a transimpedance amplifier having an input receiving a current from an input device, an output to supply an output voltage reflective of the current; and a memristor component connected in a feedback path of the transimpedance amplifier, the memristor component transitioning between a high resistive state and a low resistive state depending on a voltage difference across the memristor component. The gain of the transimpedance amplifier is reduced as the increase in current approaches a saturation level of the amplifier and triggers the transition. The result is an increase in dynamic range of the transimpedance amplifier to better match the range of current output that may be expected from say an optical input device.

IPC Classes  ?

• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• H10N 70/20 - Multistable switching devices, e.g. memristors

Abstract

Provided is reward system activation for therapeutic purposes. Accordingly there is provided a method of treating a disease in a subject in need thereof, the method comprising subjecting the subject to a treatment module which activates the reward system of the subject.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

A method and system in the present invention allow to detect and analyse chemical compounds in a sample subjected to chromatographic separation on a layered medium. The system comprises a detector comprising an array of sensors printed on each layer of the separating medium, and providing information on the presence and properties of the tested compounds in the sample. The machine-learning methods used in the method of the invention are shown to be the methods of choice when analysing the spectrometry data, for example μGC data, in a variety of scenarios and in a variety of applications, including real-time molecular analysis. These machine-learning methods can effectively learn the spectroscopic and chromatographic models taking into account various kinetic and thermodynamic parameters and by that constitute an advantageous alternative to traditional spectroscopic and chromatographic analytical methods.

IPC Classes  ?

• G01N 30/95 - Detectors specially adapted thereforSignal analysis
• G01N 30/92 - Construction of the plate
• H05K 1/16 - Printed circuits incorporating printed electric components, e.g. printed resistor, capacitor, inductor
• H05K 3/12 - Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using printing techniques to apply the conductive material

Abstract

A method of increasing proliferation of adaptive immune cells of a subject at least 65 years old is provided. The method comprising contacting the immune cells with an agent which increases the level of labile iron in the immune cells and/or reduces toxicity of hemoglobin, heme or a degradation product thereof, thereby increasing the proliferation of the adaptive immune cells of the subject.

IPC Classes  ?

• A61K 33/26 - IronCompounds thereof
• A61K 31/49 - Cinchonan derivatives, e.g. quinine
• A61K 38/38 - Albumins
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61P 37/04 - Immunostimulants

Abstract

A method comprising: receiving a radiographic image dataset representing a sequential radiographic scan of a region of a human subject; receiving three-dimensional (3D) image data representing an optical scan of a surface of said region, wherein said 3D image data is performed simultaneously with said sequential radiographic scan; estimating a time-dependent motion of said subject during said acquisition, relative to a specified position, based, at least in part, on said 3D image data; and using said estimating to determine corrections for said radiographic image dataset, based, at least in part, on a known transformation between corresponding coordinate systems of said radiographic image dataset and said 3D image data.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• G06T 7/38 - Registration of image sequences
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The present disclosure relates to the microbiome field. More specifically, the present disclosure relates to bacteriophages as a tool to manipulate gut immune-modulatory activity and uses thereof for therapy. More specifically, the present disclosure provides methods and tools for modulating an immune response in a subject in need thereof, by applying bacteriophage that modulates the phenotype of at least one bacteria in a subject.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/73 - Expression systems using phage lambda regulatory sequences
• A61P 37/00 - Drugs for immunological or allergic disorders
• A61P 37/02 - Immunomodulators
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 35/66 - Microorganisms or materials therefrom
• A61K 35/74 - Bacteria

Abstract

An indirectly heated phase change switch (IPCS) for radio frequency (RF) switching, comprises two RF ports and an RF path therebetween, a phase change material (PCM) located between the RF ports, an embedded heater separated from the PCM by a dielectric layer, the embedded heater configured to provide thermal actuation of the PCM to bring about phase changes between a crystalline state and an amorphous state to provide Ohmic switching, and a bias voltage on the IPCS across said RF path. The bias is provided during heating to improve the crystallization time.

IPC Classes  ?

• H03K 17/51 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components
• H03K 3/01 - Circuits for generating electric pulsesMonostable, bistable or multistable circuits Details

Abstract

Compositions and methods for treating a medical condition are provided. Accordingly, there is provided a composition comprising a polypeptide comprising a GnRH receptor binding protein and a polynucleotide coding a therapeutic agent, wherein said polypeptide is in association with said polynucleotide via a linker comprising a cleavage motif that can be cleaved by a proteolytic enzyme secreted by a cell expressing said GnRH receptor. Also provided is a nucleic acid construct comprising a nucleic acid sequence encoding a fusion protein comprising a DNA binding domain (DBD) of a transcription factor that binds a regulatory region of a gonadotropin gene attached to a chromatin modifying domain that represses transcription upon association with the DBD. Also provided are methods of use thereof.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 7/23 - Luteinising hormone-releasing hormone [LHRH]Related peptides

Abstract

A principle which enables the generation of macroscopic Fock and sub-Poissonian states is disclosed. Generic components of the system include: an electromagnetic structure (possessing one or more electromagnetic resonances), a nonlinear electromagnetic element (such as a nonlinear crystal near or inside the structure), and a source of light. In one embodiment, stimulated gain is used to create large numbers of photons in a cavity, but with very low photon number noise (uncertainty) in the cavity, and thus acts as a Fock laser. This Fock laser is capable of producing these states due to a very sharp intensity-dependent gain (or loss) that selects a particular photon number. The disclosed system and method are robust against both atomic and optical decoherence. Various examples of the new Fock laser design are also described.

IPC Classes  ?

• H01S 1/00 - Masers, i.e. devices using stimulated emission of electromagnetic radiation in the microwave range

Abstract

The invention generally concerns a mechano-chemical process for upcycling or recycling of polymeric waste.

IPC Classes  ?

• C08J 11/12 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by dry-heat treatment only
• B29B 17/04 - Disintegrating plastics

Abstract

The present disclosure relates to reversible phase variations in bacteria e.g., residing in a microbiome or any environment, and uses thereof in determining a physiological and/or environmental condition or state of a subject or a media and/or or habitat. The present disclosure thus provides methods and personalized therapeutic methods and kits.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• A61P 35/00 - Antineoplastic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A method comprising: generating a parametrized three-dimensional (3D) body surface model on a training set comprising a plurality of 3D scans of subjects, wherein at least some of said 3D scans are of subjects having a skeletal deformity; receiving one or more target 3D scans of a target subject; optimizing said body surface model with respect to said one or more target 3D scans to calculate a target body surface model of said target subject; training a skeletal estimation model on a training set comprising: (i) body surface models of a plurality of subjects, and (ii) skeletal landmarks sets of said plurality of subjects; and applying said trained skeletal estimation model to said calculated target body surface model of said target subject, to estimate a skeletal shape of said target subject.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06T 7/00 - Image analysis
• G06T 17/20 - Wire-frame description, e.g. polygonalisation or tessellation

Abstract

A method of producing spherical particles is provided herein. Also provided are compositions generated thereby and uses thereof in disease diagnosis and treatment.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

An objective lens system comprises a set of lenses, arranged along a common optical axis to form a back focal plane. The objective lens system also comprises an optical mask at the back focal plane, and a housing encapsulating the set of lenses and the optical mask.

IPC Classes  ?

• G02B 21/02 - Objectives
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes

Abstract

In one aspect of the invention, there is provided a nanoparticle comprising a core and a shell, wherein the core comprises a bioactive compound, and the shell comprises a lipid layer comprising a first modified lipid and a additional lipid, wherein the first modified lipid is bound to a targeted moiety via a spacer, and wherein the additional lipid comprises a polymer-bound lipid. The present invention further provides pharmaceutical compositions and methods for therapeutic and/or diagnostic use.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 25/16 - Anti-Parkinson drugs
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A method for displacement of an electromagnetic mode (EM) conditioned on the state of an ancilla qubit, the method may include displacing, by applying a displacement operation, an EM mode whose frequencies are conditioned on the state of the ancilla qubit and are spaced apart by a frequency difference, by providing a displacement signal having a bandwidth that exceeds the frequency difference and has a zero amplitude at one or more of the frequencies of the electromagnetic mode which are defined by the displacement operation not to be displaced and a non-zero amplitude at one or more frequencies of the mode which are defined by the displacement operation to be displaced.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers

Abstract

Nanoparticles comprising an outer surface covalently conjugated to 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-l-yl)methyl]benzene (AMD3100) or a derivative thereof capable of binding to C-X-C chemokine receptor type 4 (CXCR4) are provided. Methods for of treating a CXCR4 positive cancer, such as multiple myeloma or acute myeloid leukemia, in a subject in need thereof, methods of determining suitability for treatment and methods of covalently linking a molecule comprising a secondary amine to a lipid nanoparticle, are also provided.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• A61K 38/12 - Cyclic peptides
• A61K 38/50 - Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• A61K 31/255 - Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
• A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 49/00 - Preparations for testing in vivo
• A61K 9/50 - Microcapsules
• A61K 9/51 - Nanocapsules
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C12N 5/09 - Tumour cells
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Nucleic acid molecules comprising a first sequence encoding a cyclic nucleotide gated potassium channel or a functional fragment thereof and a second sequence encoding a chemogenetically activatable cyclic adenosine monophosphate (cAMP) generating receptor or a functional fragment thereof are provided. Expression vectors comprising the molecules, fusion proteins encoded by the molecules, cells, kits and pharmaceutical compositions are also provided. Methods of hyperpolarizing a cell, depolarizing a cardiac cell and treating a disease or condition are also provided.

IPC Classes  ?

• C12N 15/62 - DNA sequences coding for fusion proteins
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 15/09 - Recombinant DNA-technology
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof

Abstract

A method of fabricating a light emitting device, comprises mixing a first solution containing a polymeric component with a second solution containing quantum-confinement structures, to provide a solution mixture, and dispensing the solution mixture to form a fiber. The fiber is allow to be self-drawn such that at least one section of the fiber has a reduced diameter relative to another section.

IPC Classes  ?

• H01L 33/56 - Materials, e.g. epoxy or silicone resin
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• B29K 27/12 - Use of polyvinylhalogenides as moulding material containing fluorine
• B29K 33/00 - Use of polymers of unsaturated acids or derivatives thereof, as moulding material
• B29K 105/00 - Condition, form or state of moulded material
• B29K 509/02 - Ceramics
• B29L 31/00 - Other particular articles
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• D01D 1/02 - Preparation of spinning solutions
• D01D 5/00 - Formation of filaments, threads, or the like
• D01F 1/10 - Other agents for modifying properties
• D01F 6/12 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of halogenated hydrocarbons from polymers of fluorinated hydrocarbons
• D01F 6/16 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of unsaturated carboxylic acids or unsaturated organic esters, e.g. polyacrylic esters, polyvinyl acetate
• H01L 33/58 - Optical field-shaping elements

Abstract

An energy storage and retrieval system including an air chamber, a first air compressor operating with Heat Transfer Liquid (HTL-compressor) connected to the air chamber, a second turbine, operating with Heat Transfer Liquid (HTL-turbine) connected to the air chamber, accepting compressed air from the air chamber and producing work. Related apparatus and methods are also described.

IPC Classes  ?

• H02K 7/18 - Structural association of electric generators with mechanical driving motors, e.g.with turbines
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/92 - Chemical or biological purification of waste gases of engine exhaust gases
• F02C 6/18 - Plural gas-turbine plantsCombinations of gas-turbine plants with other apparatusAdaptations of gas-turbine plants for special use using the waste heat of gas-turbine plants outside the plants themselves, e.g. gas-turbine power heat plants

Abstract

A method and system for detecting a state of an egg. Scan values are obtained for multiple scan locations on a shell of an egg, irradiation angles, and/or collection angles, at each the egg is irradiated and reflectance and/or emission is captured at a collection point and measured by a time¬ gated detector for one or more arrival times relative to an irradiation time. The scan values are analyzed to determine information of the egg's germinal disc and a state of the egg is determined according to the information.

IPC Classes  ?

• G01N 33/08 - Eggs, e.g. by candling
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• A01K 29/00 - Other apparatus for animal husbandry
• A01K 43/00 - Testing, sorting, or cleaning eggs

Abstract

Provided are methods for diagnosing or selecting a mammal in need of a stimulant ADHD drug, conducting a non-specific electro-dermal responses (EDAs) analysis and/or an auditory sustained attention (ASAT) analysis on the mammal and administering or adjusting the dose of a stimulant ADHD drug to be administered to the mammal.

IPC Classes  ?

• A61K 31/4458 - Non-condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/0533 - Measuring galvanic skin response
• A61B 5/12 - Audiometering
• A61B 5/16 - Devices for psychotechnicsTesting reaction times

Abstract

A haptic feedback device is disclosed. The haptic feedback device may include at least one texture emulator; a housing at least partially containing the texture emulator; and a controller configured to: receive instructions to provide a texture sensation; and control the texture emulator to apply force to at least one location on a surface based on the received instructions.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

A solid hydrogel material comprising a plant-based protein and the agent is provided, wherein the agent is selected from a carboxylic acid and glycol or combination thereof. Further, articles comprising the hydrogel of the invention are also provided.

IPC Classes  ?

• C08H 1/00 - Macromolecular products derived from proteins
• B65D 65/46 - Applications of disintegrable, dissolvable or edible materials

Abstract

A polymeric article comprising a plurality of convergent vertical structures bound to a support, wherein the article is composed of (i) a non-crosslinked biodegradable polymer, (ii) a crosslinked polymer, and (iii) a tissue-adhesive polymer, and use thereof such as for sealing a biological tissue is provided.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/70 - Web, sheet or filament bases

Abstract

A crocheting device is disclosed, configured to receive a continuous feed of textile material and produce therefrom a crochet structure. The device comprising a feed mechanism configured to receive a portion of the textile material and regulate tension thereof, a looping mechanism configured to draw tensioned textile material from the feed mechanism and form one or more loops therefrom, and a crocheting mechanism configured to receive the one or more loops from the looping mechanism and successively interlock them to one or more loops of the produced crochet structure.

IPC Classes  ?

• D04B 33/00 - Crocheting tools or apparatus
• D04B 31/02 - Crocheted strips or threads
• D04B 35/16 - Indicating, warning, or safety devices, e.g. stop motions responsive to thread breakage with detectors associated with a series of threads

Abstract

RNA-protein granules comprising fusion proteins and RNA are disclosed, as well as uses thereof for treating or preventing viral infection. Soluble fusion proteins comprising an extracellular domain of a human receptor or a fragment thereof and a bacteriophage coat protein, as well as synthetic microcarriers comprising a solid support conjugated to a plurality of viral proteins or fragments thereof are provided. Nucleic acid molecules and vectors encoding the soluble fusion protein, synthetic RNA-protein granules comprising a fusion protein, as well as method using the soluble fusion protein are also provided.

IPC Classes  ?

• C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

A method for estimating parameters of a model that is non-linear and is more complex than a log-linear model, the method may include feeding measured observations and sampling coordinates of the measured observations to a machine learning process; and processing the measured observations and the sampling coordinates of the measured observations, by the machine learning process, to provide an estimate of the parameters of the model; wherein the model is indicative of a relationship between the measured observations and the sampling coordinates.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

Compositions-of-matter containing a plurality of edible microstructures (e.g., microparticles) made of a plant protein extract, composites containing such compositions-of-matter and cells adhered to the microstructures, and processes of preparing same, are provided. Also provided are food products containing these composites and methods of preparing same.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• A23J 3/14 - Vegetable proteins
• C12N 9/10 - Transferases (2.)

Abstract

A method for converting heat to mechanical work includes providing incoming heat transfer liquid (HTL) at a first temperature to a plurality of mixing chambers, providing incoming compressed gas at a second temperature to the plurality of mixing chamber, enabling the gas and the HTL to mix, producing a gas-and-HTL mix, enabling the HTL in the gas-and-HTL mix to heat the gas and isothermal expansion of the gas in the gas-and-HTL mix, limiting volume of the gas-and-HTL mix, thereby increasing pressure of the gas and causing acceleration of a flow of the gas-and-HTL mix, causing the gas-and-HTL mix to eject through a plurality of nozzles, thereby converting the heat of the HTL to kinetic energy to cause movement of the plurality of nozzles; and using the kinetic energy to produce mechanical work.

IPC Classes  ?

• F01K 27/00 - Plants for converting heat or fluid energy into mechanical energy, not otherwise provided for
• F01K 21/04 - Steam engine plants not otherwise provided for using mixtures of steam and gasPlants generating or heating steam by bringing water or steam into direct contact with hot gas
• F01K 25/06 - Plants or engines characterised by use of special working fluids, not otherwise provided forPlants operating in closed cycles and not otherwise provided for using mixtures of different fluids

Abstract

An assembly for driving movement of an elongate surgical tool, comprising: An assembly for driving movement of an elongate surgical tool, comprising: a plurality of adjacent pairs of driving wheels, each pair of driving wheels having a space therebetween such that spaces of the plurality of pairs of driving wheels are axially aligned to form a channel for the elongate surgical tool to extend through; wherein at least one pair of driving wheels out of the plurality of pairs is arranged to lie on a plane different than a plane on which at least one other pair of driving wheels lies.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61M 25/00 - CathetersHollow probes

Abstract

A system and method is presented for imaging a biological tissue, marked by metal particles, in at least one region of interest in the biological tissue. The system comprises: a frequency modulated continuous wave (FMCW) transceiver system comprising at least one radiation transmitter and at least one radiation receiver, the FMCW transceiver being configured to transmit series of millimeter wavelength signals to interact with each of said at least one region of interest and receive radiation originated within a field of view of the transceiver, and generate raw measured data indicative of received radiation; and a control system configured and operable to receive and process said raw measured data, the processing comprising extracting from said raw measured data, data indicative of radiation response of said metal particles to said interaction with the millimeter wavelength signals for each of said at least one region of interest, and determining map data indicative of a distribution of said metal particles within each region of interest.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01R 29/08 - Measuring electromagnetic field characteristics
• H01Q 1/00 - Details of, or arrangements associated with, antennas

Abstract

Systems for detecting fluorescence from a molecule comprising an ion-impermeable film comprising at least one ion-conducting nanopore and a laser coupling slot; a first and second liquid reservoir separated by the film; a means to induce movement of the molecule from the first reservoir to the second reservoir via the nanopore; a light source capable of exciting the molecule to emit fluorescence, wherein the light source shines into the second reservoir; a metallic layer adhered to the film by an adhesion layer and comprising a nanowell structure located adjacent to the nanopore; and a detector configured to detect the fluorescence emitted by the molecule are provided. Methods of use of the systems are also provided.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

Methods of determining the identity of a protein of interest within a sample comprising running the sample through a porous media within a nanochannel, determining a dynamic trajectory of the protein of interest as it moves through the porous media, measuring abundance of at least one amino acid in the protein and determining the protein's identity based on the abundance of the amino acid and at least one parameter calculated from the dynamic trajectory; are provided. Methods of detecting a protein in a stream of images taken of a porous media in a nanochannel are also provided.

IPC Classes  ?

• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A thermoacoustic device that includes a resonator, wherein the resonator includes a stack. During operation, a cold zone of the stack is configured to receive at least one fluid from a hot zone of the stack; wherein a temperature of the hot zone exceeds a temperature of the cold zone. The thermoacoustic device also includes a conveyor for conveying at least some of the at least one fluid from the cold zone of the stack to the hot zone of the stack.

IPC Classes  ?

• F25B 9/00 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point
• F25B 27/00 - Machines, plants or systems, using particular sources of energy
• F25B 23/00 - Machines, plants or systems, with a single mode of operation not covered by groups , e.g. using selective radiation effect

Abstract

The present invention provides a pharmaceutical composition including a combination of one or more cannabinoids, and a methods of using same, such as for treating any one of: a wound, regenerating skin, alopecia, an inflammatory skin disease, a sebaceous gland proliferative disease, and any disorder, condition, or symptom associated therewith.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
• A61P 17/06 - Antipsoriatics
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

An optical frequency sensor that includes (i) a heterodyne modulation and splitting unit that is configured to receive a first laser signal, modulate the first laser signal to provide a modulated laser signal and split the modulated laser signal to provide pre-processed optical signals; (ii) a self-coherent interferometer that includes (ii.1) a first optical processor that is configured to process the pre-processed optical signals to provide processed optical signals, and (ii.2) a detection unit that is configured to electro-optically mix the processed optical signals and photodetect an outcome of the mixing to provide detection signalsm and (iii) a signal processor configured to process the one or more digital signals to provide digital information about the first laser signal.

IPC Classes  ?

• G01J 3/45 - Interferometric spectrometry
• G01J 3/32 - Investigating bands of a spectrum in sequence by a single detector

Abstract

A charged particles beam column for inspecting a sample in a sample plane is presented. The charged particles beam column comprises: a charged particles source generating a charged particles beam propagating along a general propagation path towards the sample plane; and at least one charged particles beam shaping unit. The charged particles shaping unit comprises at least one high-frequency electromagnetic radiation generator located in a vicinity of said general propagation path of the charged particles beam and controllably operated to perform synchronized generation of said high-frequency electromagnetic radiation towards at least one interaction region in said general propagation path, to cause interaction between said radiation and the charged particles, thereby directly affecting energy properties of the charged particles passing through said at least one interaction region in the general propagation path and directly affecting spectral resolution of the charged particles beam at said sample plane.

IPC Classes  ?

• H01J 37/147 - Arrangements for directing or deflecting the discharge along a desired path
• H01J 37/28 - Electron or ion microscopesElectron- or ion-diffraction tubes with scanning beams

Abstract

The present invention discloses a slurry for electrode preparation, relevant to the field of electrode fabrication for various applications, which consists of an active material, a conductive additive, and a binder composition that includes a proteinaceous substance that may comprise amino acids, peptides, and/or proteins. The instantly disclosed slurry is useful in electrode fabrication, especially in the context of Li batteries. The process for preparing the electrode includes applying the slurry to a current collector and thermally treating the slurry, ensuring a durable and reliable electrode.

IPC Classes  ?

• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• H01M 4/04 - Processes of manufacture in general

Abstract

The present invention provides kits and compositions for e.g., hypergolic ignition of rocket propellant. The disclosed kits and the compositions comprise inter alia a fuel, a gelling agent, and an ignition agent; wherein the ignition agent is stably dissolved within the fuel.

IPC Classes  ?

• C06B 27/00 - Compositions containing a metal, boron, silicon, selenium or tellurium or mixtures, intercompounds or hydrides thereof, and hydrocarbons or halogenated hydrocarbons
• C06B 23/00 - Compositions characterised by non-explosive or non-thermic constituents
• C06B 47/02 - Compositions in which the components are separately stored until the moment of burning or explosion, e.g. "Sprengel"-type explosivesSuspensions of solid component in a normally non-explosive liquid phase, including a thickened aqueous phase the components comprising a binary propellant

Abstract

The present disclosure provides modulators of proteasome dynamics and/or function in a mammalian cell, compositions and uses thereof. The disclosed modulating compounds are characterized by affecting at least one of: mammalian target of rapamycin (mTOR) activation and/or lysosomal association, proteasome cellular localization, the activity and/or level/s and/or the post translational modification/s (PTM/s), and/or subcellular localization of at least one signaling molecule participating directly or indirectly in at least one pathway mediating said proteasome dynamics/function.

IPC Classes  ?

• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61P 35/00 - Antineoplastic agents
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A heterostructure system comprises a two-dimensional ferroelectric material on a dielectric substrate, and a two-dimensional semiconductor material having a first region disposed on the ferroelectric material and a second region disposed on the dielectric substrate, wherein an edge of the ferroelectric material is between the first region and the second region of the semiconductor material.

IPC Classes  ?

• H01L 31/113 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor being of the conductor-insulator- semiconductor type, e.g. metal- insulator-semiconductor field-effect transistor
• H01L 31/032 - Inorganic materials including, apart from doping materials or other impurities, only compounds not provided for in groups
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

This invention, in some embodiments thereof, provides a core-shell nanoparticle including a lipid-PSMA conjugate, encapsulating a liquid oil-based core. The invention further provides aqueous compositions including the core-shell nanoparticles, and methods for using same, such as for the treatment of proliferative diseases associated with PSMA upregulated expression.

IPC Classes  ?

• A61K 9/51 - Nanocapsules

Abstract

A system permitting efficient heat pump, storage of thermal energy, and retrieval of this stored thermal energy back to electricity upon demand. The system operates in two operational modes: a charging operational mode, in which thermal energy is pumped in an electrically driven compressor and is transferred into a hot heat transfer liquid reservoir by a heat transfer liquid; and a discharging operational mode, in which thermal energy from the hot reservoir is utilized in a turbine to produce kinetic energy that can be used directly or can be converted into an electric energy to be used when desired.

IPC Classes  ?

• F01K 21/02 - Steam engine plants not otherwise provided for with steam generation in engine cylinders
• F01K 25/06 - Plants or engines characterised by use of special working fluids, not otherwise provided forPlants operating in closed cycles and not otherwise provided for using mixtures of different fluids

Abstract

Methods for treating or reducing inflammation, in is in a site or an organ excluding the central nervous system of a subject in need thereof, by administering a pharmaceutical composition comprising the translocator protein ligand 2-C1-MGV-1, are provided.

IPC Classes  ?

• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• C07D 239/91 - Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 27/02 - Ophthalmic agents
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A process of depositing a hydrophobic or superhydrophobic film on a surface of a substrate, effected by spraying onto the substrate's surface a solution comprising a fatty acid and an organic solvent, is provided. Substrates and articles-of-manufacturing containing the substrates, having a hydrophobic or superhydrophobic coating/film deposited thereon, obtainable or prepared by the process, are also provided. The process is usable for reducing a load of a pathogenic microorganism and/or for preventing biofilm formation on and/or in the substrates or articles-of-manufacturing containing same.

IPC Classes  ?

• B05D 5/08 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain an anti-friction or anti-adhesive surface
• A23P 20/10 - Coating with edible coatings, e.g. with oils or fats
• B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
• C09D 5/14 - Paints containing biocides, e.g. fungicides, insecticides or pesticides
• C09D 7/20 - Diluents or solvents
• C09D 7/63 - Additives non-macromolecular organic
• D06M 13/188 - Monocarboxylic acidsAnhydrides, halides or salts thereof

Abstract

The present invention provides compounds and pharmaceutical compositions comprising thereof. Further, methods for treating or preventing development of a RNF4 related disorder in a subject in need thereof are also provided.

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 35/00 - Antineoplastic agents

Abstract

A method of designing a radar, comprises receiving data pertaining to a set of reflected signals received from a distribution of objects by a respective set of receiving antennas at a respective set of locations, and feeding the data and the locations as training data to a machine learning procedure. The machine learning procedure calculates, simultaneously, a set of learned antenna locations and a set of learned parameters associating the signals with the objects, thereby providing a trained machine learning procedure parametrized by the set of learned parameters.

IPC Classes  ?

• G01S 7/40 - Means for monitoring or calibrating
• G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section

Abstract

Polymeric ion conductors composed of a polymeric matrix associated with an isoindolinium moiety represented by Formula I as described in the specification are provided. Anion conducting compositions comprising an anion conducting polymer associated with, or threaded within and having mechanically interlocked therearound, a cyclic moiety are also provided. lonomeric materials, including, for example, ion exchange membranes such as anion exchange membranes, made of the polymeric ion conductor and/or the anion conducting composition, and electrochemical systems and articles-of-manufacturing containing the polymeric ion conductor, the anion conducting composition or the ion exchange membrane are also provided.

IPC Classes  ?

• B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
• B01J 41/05 - Processes using organic exchangers in the strongly basic form
• B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
• C07D 209/44 - Iso-indolesHydrogenated iso-indoles
• C08F 212/08 - Styrene
• C08J 5/22 - Films, membranes or diaphragms
• H01M 8/083 - Alkaline fuel cells
• H01M 8/103 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having nitrogen, e.g. sulfonated polybenzimidazoles [S-PBI], polybenzimidazoles with phosphoric acid, sulfonated polyamides [S-PA] or sulfonated polyphosphazenes [S-PPh]

Abstract

In a range imaging system, a passive optical system has a set of lenses and an optical mask that varies a point spread function of the set of lenses so as to encode in an optical field arriving from a scene range information for objects in the scene that are at least X meters from the mask, where X is at least 10. A digital light sensor receives the optical field, and an image processor processes signals receive signals from the sensor to decode the range information.

IPC Classes  ?

• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G06T 5/20 - Image enhancement or restoration using local operators
• G06T 5/73 - DeblurringSharpening

Abstract

The present disclosure is related to the field of machine learning (ML) based detection and classification. More specifically, the present disclosure provides computer implemented methods of detection and multi-class classification of objects of interest in an image, computer program product operable in a computer, and diagnostic methods thereof.

IPC Classes  ?

• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06F 18/2431 - Multiple classes

Abstract

The present invention is directed to a kit and a method for determining the suitability of a subject to a treatment using a tumor necrosis factor alpha (TNFα). Further provided is a method for treating the subject determined to be suitable for a treatment using a TNFα inhibitor.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease

Abstract

The present invention relates to functional taste-improving composition comprising at least one taste-modifying protein (TMP), e.g., a sweet protein (SP) and at least one micropatching (MP) agent; and to uses thereof in the food and beverage industry.

IPC Classes  ?

• A23L 27/00 - SpicesFlavouring agents or condimentsArtificial sweetening agentsTable saltsDietetic salt substitutesPreparation or treatment thereof
• A23L 2/60 - Sweeteners
• A23L 27/20 - Synthetic spices, flavouring agents or condiments
• A23L 27/21 - Synthetic spices, flavouring agents or condiments containing amino acids
• A23L 27/30 - Artificial sweetening agents

Abstract

A method of image enhancement of a reflectance confocal microscope is disclosed. The method comprises: receiving by a processor a first image captured by a detector of the confocal microscope, at a first position of a pinhole; receiving one or more second images captured by the detector, at at least one second position of the pinhole; and adding, by the processor, the one or more second images to the first image to reduce a speckle contrast in the combined image. In addition, the first position of the pinhole is a confocal position, and the at least one second position is a shifted position with respect to the confocal position.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

The present disclosure provides a novel configuration of a fluid pressurization nozzle which is relatively simple in its mechanical design for attaining an isothermal or quasi-isothermal pressurization process of fluid, e.g., isothermal or quasi-isothermal compression of gas. The fluid pressurization nozzle of the present disclosure utilizes the general principles of an expanding-contracting nozzle (e.g., Venturi nozzle), which is modified for eliminating or significantly attenuating generation of shock waves in the nozzle to thereby facilitate efficient compression of the gas. The fluid pressurization nozzle of the present disclosure has a profile defining a varying cross-section along a length thereof. As such, the fluid pressurization nozzle is configured for affecting / manipulating characteristics / properties of fluid(s) propagating therealong. Such properties can include, inter alia, pressure, Mach number, velocity, and temperature. Optionally, and in some embodiments preferably, the fluid compression nozzle of the present disclosure is configured to pressurize suction fluid (e.g., gas) introduced thereinto, with the aid of a heat transfer liquid (HTL) propagating / flowing therealong. The introduced suction fluid is mixed with the HTL to form a liquid/gas mixture in which the gas is pressurized.

IPC Classes  ?

• F04F 5/04 - Jet pumps, i.e. devices in which fluid flow is induced by pressure drop caused by velocity of another fluid flow the inducing fluid being liquid displacing elastic fluids
• F04F 5/46 - Arrangements of nozzles

Abstract

A method for estimating an information unit represented by DNA strands, the method includes (a) sequencing the DNA strands to provide noisy copies of an encoded version of the information unit; wherein the information unit comprises information unit elements; (b) neural network (NN) processing the multiple noisy copies by one or more NNs to provide a soft estimate of the encoded information unit; wherein the soft estimate comprises estimated encoded information unit elements and an encoded information unit elements estimated confidence parameter; and (c) decoding the soft estimate of the encoded information unit to provide a prediction of the information unit.

IPC Classes  ?

• G06N 3/123 - DNA computing
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

A composition and method for the administration of therapeutic and/or diagnostic agents is provided. Specifically, a dry hybrid system, composed of bio adhesive polymer that harbors drug-loaded lipid nanoparticles, and use thereof for the administration of active agents e.g., anti-cancer agents or biological agents, is provided.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

A foot support structure having: a foot support surface for engagement by a foot of a subject; and a tissue loading alleviation zone within the foot support surface, such that the tissue loading alleviation zone defines a region of the foot support surface configured for optimizing an internal tissue loading state in a volume-of-interest (VOI) in said foot of said subject, and the region has at least one mechanical property value that gradually varies along at least one dimension of the region.

IPC Classes  ?

• A43B 7/1455 - Footwear with health or hygienic arrangements with foot-supporting parts with pads or holes on one or more locations, or having an anatomical or curved form with special properties
• A43B 7/144 - Footwear with health or hygienic arrangements with foot-supporting parts with pads or holes on one or more locations, or having an anatomical or curved form characterised by the location under the foot situated under the heel, i.e. the calcaneus bone
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes

Abstract

The present invention provides a nanoparticle including: (a) an amphiphilic co-polymer including an ionizable polymer covalently bound to a hydrophobic domain; and a polynucleotide comprising 60 to 500 nucleobases. Further provided are compositions including the nanoparticle of the invention, and methods of using same.

IPC Classes  ?

• A01N 63/60 - Isolated nucleic acids
• A01N 25/12 - Powders or granules
• A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof

Abstract

Embodiments of the invention relate to a corrole according to formula [I]; wherein R1, R2, and R3 are each independently H, —COOH, CF3, or a halide selected from the group consisting of F—, Cl—, Br— and I, with the proviso that R1, R2, and R3 can not all be CF3, and when the compound is of Formula II, wherein M is a metallic ion or an elemental ion selected from the group consisting of an elemental ion of group 13-16 in row 3 or above and boron, preferably selected from the group consisting of: Fe, Mn, Ga, P, Mo, Re, Co and Cu, or a salt thereof. Methods for treatment, catalysis, and detection using the compounds are also described.

IPC Classes  ?

• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
• C07F 13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic Table
• C07F 15/02 - Iron compounds
• C07F 15/06 - Cobalt compounds

Abstract

A thermoacoustic engine that consists essentially of: a heat exchanger; and a resonator that is in communication with the heat exchanger. The resonator includes a media configured to absorb one or more electromagnetic signals. The thermoacoustic engine is configured to receive the one or more electromagnetic signals and generate acoustic power.

IPC Classes  ?

• F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
• G10K 15/04 - Sound-producing devices
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to a composition comprising a mixture of oligomers or co-oligomers obtained by exposing an indolium-based monomer, optionally together with an additional monomer selected from dopamine, L-dopa, norepinephrine, serotonin, and a mixture thereof, to a basic buffer. The composition disclosed may further comprise a hydrophobic substance such as a drug or dietary supplement, stabilized by said oligomers above.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
• A61K 35/02 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents

Abstract

Polymeric ion conductors composed of a polymeric or co-polymeric backbone which comprises a plurality of backbone units, a metal ligand attached to at least a portion of the backbone units, and a metal ion attached to the metal ligand are provided. The metal ligand can be an N-heterocyclic carbene ligand and the metal can feature low oxophilicity. lonomeric materials, including, for example, ion exchange membranes such as anion exchange membranes, made of the polymeric ion conductor, and electrochemical systems and articles-of-manufacturing containing the polymeric ion conductor or the ion exchange membrane are also provided.

IPC Classes  ?

• H01M 8/1023 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
• H01M 8/1067 - Polymeric electrolyte materials characterised by their physical properties, e.g. porosity, ionic conductivity or thickness

Abstract

An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.

IPC Classes  ?

• A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
• A61L 27/38 - Animal cells

Abstract

The present invention provides a pharmaceutical composition including cannabigerol, and methods of using same, such as for increasing therapeutic efficacy of an immune checkpoint inhibitor, or for the treatment of cancer.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

A method for reconstructing spatial information, the method includes: (i) Obtaining an under-sampled frequency domain representation (FDR) of the spatial information. The under-sampled FDR was obtained by sampling an FDR of the spatial information with a sampling mask. (ii) Feeding the under-sampled FDR and the sampling mask to a machine learning process. (iii) Reconstructing the spatial information by the machine learning process. The machine learning process was trained using a training data set that includes training under-sampled FRDs of training spatial information, and one or more training sampling masks that were used to sample FDRs of training spatial information.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A pump system wherein a pressure storage unit configured to receive input pressure for build-up of pressurized gaseous material thereinside and communicate the same to a pumping unit at least partially submerged in a body-of-liquid. The pumping unit comprises an internal liquid passage extending upwardly a certain length from a bottom opening thereof, a discharge tube at least partially accommodating by a bottom end potion thereof a portion of the internal liquid passage, a gas -liquid vessel in fluid communication with the discharge tube and configured to receive via an upper portion thereof pressurized gaseous material from the pressure storage unit, to thereby lift a certain amount of liquid towards a liquid outlet of the discharge tube.

IPC Classes  ?

• E21B 43/12 - Methods or apparatus for controlling the flow of the obtained fluid to or in wells
• F04B 47/08 - Pumps or pumping installations specially adapted for raising fluids from great depths, e.g. well pumps having motor-pump units situated at great depth the motors being actuated by fluid
• F04F 1/08 - Pumps using positively or negatively pressurised fluid medium acting directly on the liquid to be pumped the fluid medium acting on the surface of the liquid to be pumped specially adapted for raising liquids from great depths, e.g. in wells

Abstract

An isolated peptide comprising an amino acid sequence of a lysyl oxidase (LOX) family member target site of an extracellular matrix protein, the peptide being no longer than 50 amino acids, for use in treating a disease associated with fibrosis in a subject in need thereof.

IPC Classes  ?

• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

A method and system for implementing a machine-learning (ML) based function may include providing a NN model comprising a plurality of NN parameters; training the NN model over a plurality of training epochs, to implement a predefined ML function, based on a training dataset; for one or more NN parameters of the plurality of NN parameters: (i) calculating a profile vector, representing evolution of the NN parameter through the plurality of training epochs; and (ii) calculating an approximated value of the at least one NN parameter, based on the profile vector; and replacing at least one NN parameter value in the trained NN model with a respective calculated approximated value, to obtain an approximated version of the trained NN model.

IPC Classes  ?

• G06N 3/084 - Backpropagation, e.g. using gradient descent
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]