Abstract

The present invention relates to column packing material and methods of making thereof. In particular, the present invention relates to column packing material that is used in Hydrophilic Interaction Liquid Chromatography (HILIC).

IPC Classes  ?

• B01J 20/26 - Synthetic macromolecular compounds
• C08L 83/10 - Block- or graft-copolymers containing polysiloxane sequences

Abstract

Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a support system is provided for a scientific instrument. The support system is configured to acquire, for each of a plurality of scientific instrument groups, asset information associated with the scientific instrument group. The scientific instrument group includes at least one scientific instrument. The support system is also configured to acquire, for each of the plurality of scientific instrument groups, reservation information associated with the scientific instrument group. The support system is also configured to generate, for each of the plurality of scientific instrument groups, a status card including status information associated with the scientific instrument group. The status information is at least based on the asset information and the reservation information. The support system is configured to provide a first user interface for displaying the status cards.

IPC Classes  ?

• G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations

Abstract

Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a support system is provided for a scientific instrument. The support system is configured to acquire, for each of a plurality of scientific instrument groups, asset information associated with the scientific instrument group. The scientific instrument group includes at least one scientific instrument. The support system is also configured to acquire, for each of the plurality of scientific instrument groups, reservation information associated with the scientific instrument group. The support system is also configured to generate, for each of the plurality of scientific instrument groups, a status card including status information associated with the scientific instrument group. The status information is at least based on the asset information and the reservation information. The support system is configured to provide a first user interface for displaying the status cards.

IPC Classes  ?

• G05B 23/02 - Electric testing or monitoring

Abstract

An ion repulsive surface, comprises: a first plurality of elongated electrodes distributed along an axis, configured to receive a first RF voltage with an asymmetric waveform; and a second plurality of elongated electrodes distributed along the axis, the second plurality of electrodes being interleaved with the first plurality of electrodes and configured to receive a second RF voltage with an asymmetric waveform, having a different phase than the first RF voltage. The first and second plurality of electrodes and first and second RF voltages are configured such that a strength of an electric field adjacent the ion repulsive surface is sufficient for ions to experience mobility variation. An ion optical device may be provided from such an ion repulsive surface, from which an ion optical system, ion optical interface, mass spectrometer and/or ion mobility spectrometer may be considered.

IPC Classes  ?

• G01N 27/624 - Differential mobility spectrometry [DMS]Field asymmetric-waveform ion mobility spectrometry [FAIMS]
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

A multipole ion optical device comprises: a first plurality of electrodes distributed along a first axis; and a second plurality of electrodes distributed along a second axis, generally parallel to the first axis, to define an ion channel between the first and second pluralities of electrodes. Each of the first plurality of electrodes and the second plurality of electrodes is configured to receive a respective RF voltage having an asymmetric waveform and such that adjacent electrodes of the first and second pluralities of electrodes receive RF voltages having different phases. The first and second plurality of electrodes and the plurality of RF voltages are configured such that a strength of an electric field in the ion channel is sufficient for ions to experience mobility variation.

IPC Classes  ?

• G01N 27/624 - Differential mobility spectrometry [DMS]Field asymmetric-waveform ion mobility spectrometry [FAIMS]
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

An ion optical device comprises: first and second electrode arrangements, spatially separated from one another, for receiving ions and a gas and arranged to operate in a high gas pressure environment; and an RF voltage supply applying: a first RF voltage comprising one or more RF drive frequencies to the first electrode arrangement; and a second RF voltage of the one or more RF drive frequencies, having a different phase, to the second electrode arrangement, wherein the first and second RF voltages have an asymmetric waveform, the application of the first and second RF voltages to the first and second electrodes arrangements respectively causing the received ions to experience an electric field. The first and second electrode arrangements and the RF voltage supply are configured such that a strength of the electric field experienced by the received ions is sufficient for ions to experience mobility variation.

IPC Classes  ?

• G01N 27/624 - Differential mobility spectrometry [DMS]Field asymmetric-waveform ion mobility spectrometry [FAIMS]
• H01J 49/00 - Particle spectrometers or separator tubes

Abstract

A method of separating a sample of ions according to their ion mobilities is provided. The method comprises receiving the sample of ions into a drift tube; applying a first electric field component within the drift tube so as to cause the sample of ions to move along a path within the drift tube, whereby the sample of ions separates along the path; and applying a second electric field component within the drift tube. The first and second electric field components have a combined electric field strength to modify the ion mobility of at least a portion of the sample of ions and to increase the separation of at least a portion of the sample of ions along the path The second electric field component substantially does not cause a net change in the velocity of the sample of ions perpendicular to the path. An apparatus for separating a sample of ions according to their ion mobilities is also provided.

IPC Classes  ?

• G01N 27/622 - Ion mobility spectrometry

Goods & Services

Laboratory equipment-namely, vials used for scientific purposes and parts therefor.

Abstract

A chromatographic materialcomprisinga zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R1, R2, R3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L1, L2 and L3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L1, L2 and L3; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R4, R5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.

IPC Classes  ?

• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
• B01J 20/289 - Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
• B01J 20/32 - Impregnating or coating

Abstract

A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: f is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.

IPC Classes  ?

• C07F 7/04 - Esters of silicic acids
• G01N 30/02 - Column chromatography
• C07F 7/08 - Compounds having one or more C—Si linkages
• C07B 63/00 - PurificationSeparation specially adapted for the purpose of recovering organic compoundsStabilisationUse of additives

Goods & Services

Software application which facilitates selection of liquid chromatography columns appropriate for a particular sample or method.

Abstract

A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cagecarry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially ina Stöber or modified Stöber process.

IPC Classes  ?

• B01J 20/283 - Porous sorbents based on silica
• B01J 20/287 - Non-polar phasesReversed phases
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate

Goods & Services

Kits comprising enzymatic reagents, buffers and empty vials for use in proteolytic digestion.

Abstract

A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6). The bed may comprise a plurality of bed sections and each bed section has an average particle diameter calculated from the particles in that section and there are at least two different average particle diameter bed sections, wherein the particles of each bed are separated from particles of an adjacent bed by a partition that is liquid permeable to allow through a flow of mobile phase. A high column efficiency can be provided with lower pressure drop per unit length of the column.

IPC Classes  ?

• G01N 30/60 - Construction of the column
• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• G01N 30/52 - Physical parameters
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/283 - Porous sorbents based on silica
• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate

Abstract

A method for deriving a background-corrected portion of a measured optical emission spectrum comprising the steps of identifying two or more background correction points from the portion of the measured emission spectrum; deriving a background correction function fitted to the identified background correction points, and applying the background correction function to the portion of the measured emission spectrum so as to produce a background-corrected portion of the emission spectrum, wherein the background correction points are identified from the measured data points by consideration of the gradients between the measured data points.

IPC Classes  ?

• G01J 3/36 - Investigating two or more bands of a spectrum by separate detectors
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/443 - Emission spectrometry
• G01J 3/28 - Investigating the spectrum

Abstract

A laboratory vial transfer device for automatically transferring laboratory vials from a transport package containing a plurality of said vials, comprising: a vial feeder configured to connect to the transport package after the package has been opened, so as to feed vials directly from the package without manual contact, wherein the vial feeder comprises a rotatable carousel having a plurality of vial receiving positions located on the carousel each for receiving a single vial and adapted to collect the vials from the opened package into respective vial receiving positions upon operation of the carousel, wherein the carousel is operable to feed the vials from their respective vial receiving positions to an exit position.

IPC Classes  ?

• G07F 11/54 - Coin-freed apparatus for dispensing, or the like, discrete articles from movable storage containers or supports the storage containers or supports being rotatably mounted about vertical axes
• G07F 11/24 - Rotary or oscillatory members
• G07F 17/00 - Coin-freed apparatus for hiring articlesCoin-freed facilities or services
• G01N 35/04 - Details of the conveyor system
• B65G 47/84 - Star-shaped wheels or devices having endless travelling belts or chains, the wheels or devices being equipped with article-engaging elements

Goods & Services

Kits comprising chemical and biochemical reagents, buffers and empty vials for use in enzymatic proteolysis *Kits comprising enzymatic reagents, buffers and empty vials for use in proteolytic digestion*

Abstract

A device for separating components of a solution comprising: a well for receiving the solution;an exit pipe connected to the well for receiving the solution from the well wherein the exit pipe is of smaller diameter than the well; and a porous composite sorbent within the exit pipe for retaining one or more components from the solution, wherein the composite sorbent is in the form of a sintered solid composition comprising at least porous polymer particles and sorbent particles sintered together that is push fitted into the exit pipe so as to form a close fit within the exit pipe,and wherein the exit pipe has a restriction therein that acts to stop travel of the composite sorbent in the exit pipe beyond the location of the restriction. The device may be a concentrator for liquids, e.g. prior to LC or LC/MS analysis.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Superficially porous silica particles are provided as well as a one-pot process for making the superficially porous particles, the process comprising hydrolyzing and condensing a silica precursor comprising a functional group to form superficially porous particles, the superficially porous particles comprising silica microparticles having silica nanoparticles bound to the surface of the microparticles. The nanoparticles provide a porous outer layer on the microparticles. The superficially porous particles are useful as a stationary phase in liquid chromatography and allow for fast mass transfer and separation of samples.

IPC Classes  ?

• B01J 20/283 - Porous sorbents based on silica
• C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel formAfter-treatment thereof
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/32 - Impregnating or coating
• B01J 20/30 - Processes for preparing, regenerating or reactivating

Abstract

A method and apparatus for introducing droplets of liquid sample into an analysis device using a gas stream, the droplets being produced by the application of acoustic energy to a quantity of liquid sample. Acoustic energy may be applied to a quantity of liquid sample located on a solid surface of a sample support so as to eject a droplet of sample from the quantity of sample; the droplet of sample may be entrained in a gas stream; and the droplet of sample may be transported into the analysis device using the gas stream.

IPC Classes  ?

• B01L 3/02 - BurettesPipettes
• B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

A method and apparatus for mixing droplets of liquid sample and droplets of a diluent and/or a standard produced by droplet-on-demand generators for use with an analysis device. Two different liquids may be introduced to an analysis device for simultaneous analysis. The method preferably comprises using a first droplet-on- demand generator to provide a first stream of droplets of a first liquid; using a second droplet-on-demand generator to provide a second stream of droplets of a second liquid; and combining the first and second streams of droplets before they enter the analysis device.

IPC Classes  ?

• G01N 1/38 - Diluting, dispersing or mixing samples
• B01F 5/00 - Flow mixers; Mixers for falling materials, e.g. solid particles
• B01L 3/02 - BurettesPipettes
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
• B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers

Abstract

A method and apparatus for introducing droplets of liquid sample into an analysis device using a gas stream, the droplets being produced by the application of acoustic energy to a quantity of liquid sample. Acoustic energy may be applied to a quantity of liquid sample located on a solid surface of a sample support so as to eject a droplet of sample from the quantity of sample; the droplet of sample may be entrained in a gas stream; and the droplet of sample may be transported into the analysis device using the gas stream.

IPC Classes  ?

• G01N 1/00 - SamplingPreparing specimens for investigation
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• B01L 3/02 - BurettesPipettes
• B05B 17/06 - Apparatus for spraying or atomising liquids or other fluent materials, not covered by any other group of this subclass operating with special methods using ultrasonic vibrations
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01N 21/64 - FluorescencePhosphorescence
• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

A method and apparatus for mixing droplets of liquid sample and droplets of a diluent and/or a standard produced by droplet-on-demand generators for use with an analysis device. Two different liquids may be introduced to an analysis device for simultaneous analysis. The method preferably comprises using a first droplet-on-demand generator to provide a first stream of droplets of a first liquid; using a second droplet-on-demand generator to provide a second stream of droplets of a second liquid; and combining the first and second streams of droplets before they enter the analysis device.

IPC Classes  ?

• G01N 1/00 - SamplingPreparing specimens for investigation
• G01N 1/38 - Diluting, dispersing or mixing samples
• H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
• B01L 3/02 - BurettesPipettes

Abstract

A method of and apparatus for controlling the temperature of an inductively coupled or microwave induced plasma for optical emission spectrometry or mass spectrometry in which the intensities of two spectral lines of radiation emitted by the plasma are measured, and the power provided to sustain the plasma is adjusted so that the ratio of the intensities remains substantially constant.

IPC Classes  ?

• H01J 49/10 - Ion sourcesIon guns
• G01N 21/73 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using plasma burners or torches
• H01J 27/16 - Ion sourcesIon guns using high-frequency excitation, e.g. microwave excitation
• H01J 37/32 - Gas-filled discharge tubes
• H05H 1/00 - Generating plasmaHandling plasma
• G01J 3/443 - Emission spectrometry

Abstract

A method of and apparatus for controlling the temperature of an inductively coupled or microwave induced plasma for optical emission spectrometry or mass spectrometry in which the intensities of two spectral lines of radiation emitted by the plasma are measured, and the power provided to sustain the plasma is adjusted so that the ratio of the intensities remains substantially constant.

IPC Classes  ?

• C23C 14/54 - Controlling or regulating the coating process
• C23C 8/36 - Solid state diffusion of only non-metal elements into metallic material surfacesChemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases using ionised gases, e.g. ionitriding
• H01L 21/203 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth using physical deposition, e.g. vacuum deposition, sputtering

Abstract

A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6). The bed may comprise a plurality of bed sections and each bed section has an average particle diameter calculated from the particles in that section and there are at least two different average particle diameter bed sections, wherein the particles of each bed are separated from particles of an adjacent bed by a partition that is liquid permeable to allow through a flow of mobile phase. A high column efficiency can be provided with lower pressure drop per unit length of the column.

IPC Classes  ?

• G01N 30/52 - Physical parameters
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• G01N 30/60 - Construction of the column

Abstract

An apparatus and a method are provided for column chromatography, which provide improvements in separation resolution and detection sensitivity, comprising a chromatography column having an inlet and an outlet, wherein the inlet is configured to introduce a flow of mobile phase into the column carrying a sample, wherein the inlet is further configured to introduce the flow of mobile phase into the column in at least two separate portions which are independently controllable, and to introduce the portions into different radial regions of the column, such that the portions flow longitudinally through the column in different radial regions. The sample preferably is contained in one of the portions, especially a central portion, in a higher concentration than in the other portion(s). Preferably the flow velocities of the portions are independently controllable.

IPC Classes  ?

• G01N 30/60 - Construction of the column
• B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
• B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• G01N 30/22 - Injection in high pressure liquid systems

Abstract

An apparatus for reaction chromatography comprising: a chromatography column, the column having a fluid outlet for an eluate flow, wherein the fluid outlet is configured with two or more fluid ports, the two or more fluid ports comprising one or more reactant ports, wherein each reactant port is for connecting a reactant flow into the eluate flow to react with the eluate flow, and one or more product ports for receiving the reacted eluate flow; one or more reactant sources in fluid communication with the one or more reactant ports to provide the reactant flow; and one or more processing units in fluid communication with the one or more product ports to process the reacted eluate flow.

IPC Classes  ?

• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• G01N 30/60 - Construction of the column
• G01N 30/84 - Preparation of the fraction to be distributed

Abstract

Superficially porous silica particles are provided as well as a one-pot process for making the superficially porous particles, the process comprising hydrolyzing and condensing a silica precursor comprising a functional group to form superficially porous particles, the superficially porous particles comprising silica microparticles having silica nanoparticles bound to the surface of the microparticles. The nanoparticles provide a porous outer layer on the microparticles.The superficially porous particles are useful as a stationary phase in liquid chromatography and allow for fast mass transfer and separation of samples.

IPC Classes  ?

• C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel formAfter-treatment thereof
• B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
• C09C 1/00 - Treatment of specific inorganic materials other than fibrous fillers Preparation of carbon black

Abstract

An apparatus and a method are provided for column chromatography, which provide improvements in separation resolution and detection sensitivity, comprising a chromatography column, the column having an inlet and an outlet, wherein the inlet is configured to introduce a flow of mobile phase into the column carrying a sample, whereby the sample separates into components as it advances longitudinally through the column from the inlet to the outlet carried by the mobile phase, wherein the inlet is further configured to introduce the flow of mobile phase into the column in at least two separate portions which are independently controllable, and to introduce the portions into different radial regions of the column, such that the portions flow longitudinally through the column in different radial regions. The sample preferably is contained in one of the portions, especially a central portion, in a higher concentration than in the other portion(s). Preferably the flow velocities of the portions are independently controllable.

IPC Classes  ?

• B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
• B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
• G01N 30/36 - Control of physical parameters of the fluid carrier in high pressure liquid systems
• G01N 30/44 - Flow patterns using recycling of the fraction to be distributed
• G01N 30/60 - Construction of the column

Abstract

An apparatus and a method are provided for column chromatography which provide improvements in separation resolution and detection sensitivity, comprising a chromatography column, the column having an inlet and an outlet, wherein the outlet is configured to split a flow of eluate as it leaves the column through the outlet into at least two separate portions, wherein the apparatus is configured to separately process the portions, for example to separately detect a portion or separately collect fractions of a portion with improved resolution. A split frit assembly is preferably configured to split the flow of eluate. The portions preferably emanate from different radial regions of the column. An end fitting for the column outlet may be provided having multiple ports to separately convey the portions.

IPC Classes  ?

• B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
• B01D 15/24 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
• G01N 30/60 - Construction of the column

Abstract

An apparatus and a method are provided for column chromatography which provide improvements in separation resolution and detection sensitivity, comprising a chromatography column, the column having an inlet and an outlet, wherein the outlet is configured to split a flow of eluate as it leaves the column through the outlet into at least two separate portions, wherein the apparatus is configured to separately process the portions, for example to separately detect a portion or separately collect fractions of a portion with improved resolution. A split frit assembly is preferably configured to split the flow of eluate. The portions preferably emanate from different radial regions of the column. An end fitting for the column outlet may be provided having multiple ports to separately convey the portions.

IPC Classes  ?

• G01N 30/60 - Construction of the column
• B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
• B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
• B01D 15/24 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
• G01N 30/22 - Injection in high pressure liquid systems

Goods & Services

Cartridges and multi-well plates for solid phase extraction for sample preparations of organic mixtures and biological samples, in International Class 09.

Goods & Services

Instruments for laboratory research, namely, cartridges and multi-well plates for solid phase extraction for sample preparations of organic mixtures and biological samples

Abstract

A cable for the transmission of power and/or data signals having a first conductor (40), a second conductor (42) and an optically transparent insulating layer (44) separating the first conductor and second conductor, wherein the insulating layer is operable as an optical waveguide for the optical transmission of power and/or data signals along the cable. The cable is usable in a method of transmitting power and/or data signals and an interconnect system for connecting two or more electronic components.

IPC Classes  ?

• G02B 6/44 - Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables
• H01B 11/18 - Coaxial cablesAnalogous cables having more than one inner conductor within a common outer conductor

Abstract

A method for tracking a variable resonance condition in a plasma coil during creation of plasma from a gas flowing in a plasma torch adjacent to the plasma coil comprises: providing a radio-frequency (RF) power source comprising a power amplifier that generates a radio-frequency power signal with an adjustable operating frequency; providing a high-voltage ignition charge from said RF power source to the gas in plasma torch so as to create an electrical discharge through said gas so as to create a test sample comprising a partial plasma state within said plasma torch; and applying an RF power signal from said plasma coil to said test sample in said plasma torch, wherein said adjustable operating frequency of said power amplifier tracks said variable resonance condition of said plasma coil such that said test sample in the plasma torch achieves a full plasma state.

IPC Classes  ?

• H05B 31/26 - Influencing the shape of arc discharge by gas blowing devices
• G01R 23/12 - Arrangements for measuring frequency, e.g. pulse repetition rateArrangements for measuring period of current or voltage by converting frequency into phase shift

Abstract

A system and method are disclosed for implementing a power source including a power amplifier that generates a radio-frequency power signal with an adjustable operating frequency. The power amplifier also generates a reference phase signal that is derived from the radio-frequency power signal. An impedance match provides the radio-frequency power signal to a plasma coil that has a variable resonance condition. A phase probe is positioned adjacent to the plasma coil to generate a coil phase signal corresponding to the adjustable operating frequency. A phase-locked loop then generates an RF drive signal that is based upon a phase relationship between the reference phase signal and the coil phase signal. The phase-locked loop provides the RF drive signal to the power amplifier to control the adjustable operating frequency, so that the adjustable operating frequency then tracks the variable resonance condition.

IPC Classes  ?

• H05B 31/26 - Influencing the shape of arc discharge by gas blowing devices
• G01R 23/12 - Arrangements for measuring frequency, e.g. pulse repetition rateArrangements for measuring period of current or voltage by converting frequency into phase shift

Abstract

A system and method are disclosed for implementing a power source including a power amplifier that generates a radio-frequency power signal with an adjustable operating frequency. The power amplifier also generates a reference phase signal that is derived from the radio-frequency power signal. An impedance match provides the radio-frequency power signal to a plasma coil that has a variable resonance condition. A phase probe is positioned adjacent to the plasma coil to generate a coil phase signal corresponding to the adjustable operating frequency. A phase-locked loop then generates an RF drive signal that is based upon a phase relationship between the reference phase signal and the coil phase signal. The phase-locked loop provides the RF drive signal to the power amplifier to control the adjustable operating frequency, so that the adjustable operating frequency then tracks the variable resonance condition.

IPC Classes  ?

• G01R 23/12 - Arrangements for measuring frequency, e.g. pulse repetition rateArrangements for measuring period of current or voltage by converting frequency into phase shift

Goods & Services

Vials, caps, seals, inserts, plugs, sleeves, springs and supports, all for use in chromatography.