Abstract

The present invention relates to new chemical compounds of formula (I) with a structure different from nitroimidazoles, and to equally novel uses thereof for the treatment of trichomoniasis, making said compounds useful for application by means of pharmaceutical compositions. Also, the administration of said compounds does not cause adverse side effects in comparison with compounds widely known in the field, such as metronidazole.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline

Abstract

The present invention relates to novel chemical compounds of formula I with a structure different from nitroimidazoles, and to equally novel uses thereof for the treatment of trichomoniasis, making said compounds useful for application by means of pharmaceutical compositions. Also, the administration of said compounds does not cause adverse side effects in comparison with compounds widely known in the field, such as metronidazole.

IPC Classes  ?

• C07D 239/40 - One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Abstract

The present invention relates to pharmaceutical compositions that can be used for the treatment of trichomoniasis, which comprise compounds with the chemical structure and which also exhibit a synergic effect and do not have the typical side effects of compositions comprising compounds commonly used in the treatment of this disease, such as metronidazole.

IPC Classes  ?

• C07D 311/56 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
• C07D 239/40 - One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61P 33/02 - Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

The contamination of receiving water bodies by heavy metals due to anthropomorphic activities is of great significance to human health. There are metals that have a high capacity to form radicals that alter cellular functions when they exceed certain concentrations, for example, a prolonged exposure to concentrations greater than 20 mg of copper/L promotes the development of cancer. The invention relates to a thermoplastic matrix of chitosan (Ch) and polycaprolactone (PCL) for the removal of heavy metals in waste water, which, used in a ratio of 2:1 p/p respectively, offers a capacity of 62.5 mg Cu2+/g adsorbent (ads) in continuous processes with a HRT of less than 2 hours, and which permits various reuse cycles.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• C02F 1/58 - Treatment of water, waste water, or sewage by removing specified dissolved compounds
• C02F 1/62 - Heavy metal compounds
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
• B01J 20/26 - Synthetic macromolecular compounds

Abstract

The present invention relates to a molecule obtained from Krameria cytisoides for the treatment of inflammatory conditions. Specifically, the present invention relates to a cyclic polymer peroxide having anti-inflammatory pharmacological properties that is obtained from the Krameria cytisoides extract. In connection with the present invention, the cyclic polymer peroxide obtained is called "kramecyne".

IPC Classes  ?

• C07D 319/02 - 1,2-DioxanesHydrogenated 1,2-dioxanes
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel

Abstract

The invention relates to a method for producing a mixture for bioremediation, containing nixtamalized maize flour and a composition based on bacteria of the Bacillus genus. This mixture is used for bioremediation and bioagumentation involving degradation, for the decontamination of compounds, as well as eliminating bad odours and faecal coliforms and reducing the concentration of lipids, starch and proteins present in contaminated water or solid surfaces exposed to the air and affected by moisture, as well as for the degradation of cellulose in soils and fertiliser additive.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• C12N 11/02 - Enzymes or microbial cells immobilised on or in an organic carrier
• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used

Abstract

The invention relates to a chitosan presenting a degree of N-acetylation ranging from 5% to 45%, wherein its X ray powder diffractogram shows at least one characteristic peak of a crystalline form of chitin.

IPC Classes  ?

• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof

Abstract

The invention relates to the mining industry, for the treatment of minerals and materials containing gold and silver. The invention specifically relates to a method for recovering gold and silver from thiosulfate and thiourea solutions, by means of an electrolysis method with simultaneous metal deposition on the cathode and anode. The advantages of the invention compared to prior art are that the method is faster and the energy consumption is lower than that observed in conventional cells. The electrolysis is carried out in the potential zones that enable the reduction of the silver and gold on the cathode and the oxidation of the ligand on the anode.

IPC Classes  ?

• C25C 1/20 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of noble metals
• C25C 5/02 - Electrolytic production, recovery or refining of metal powders or porous metal masses from solutions
• C25D 3/46 - ElectroplatingBaths therefor from solutions of silver
• C25D 3/48 - ElectroplatingBaths therefor from solutions of gold

Abstract

The invention relates to the mining industry, for the treatment of minerals containing copper. The invention specifically relates to an oxidative process for extracting copper from refractory mineral phases containing copper. The advantage of said means compared to prior art is that it increases the leaching speed. Said means for leaching copper from an ore or from at least one mineral that cannot be easily oxidised is characterised in that it comprises an acid solution containing copper(I) ion complexing agents and a solvent that prevents the formation of passivating phases.

IPC Classes  ?

• C22B 3/06 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic acid solutions
• C22B 15/00 - Obtaining copper

Abstract

The present invention pertains to the mining industry and to the processing of minerals and materials containing gold and silver. More specifically, it relates to a method for recovering gold and silver from copper thiosulphate solutions by a self-sustaining electrolytic process. The advantages of the present invention over the prior art are that it is faster than cementation with copper, without using electric current. The claimed method is characterised in that it is performed in a self-sustaining electrochemical cell in which the anode and cathode are short-circuited; and the anode and cathode compartments are separated by an ion exchange membrane. Moreover, the provision of a copper anode and the use of a stripping solution as the anolyte allow soluble copper levels to be kept stable, thus preserving the leaching power of thiosulphate solutions, and allowing them to be recycled in a new leaching step.

IPC Classes  ?

• C25C 1/20 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of noble metals
• C25C 7/06 - Operating or servicing
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C25C 7/00 - Constructional parts, or assemblies thereof, of cellsServicing or operating of cells
• C25D 3/46 - ElectroplatingBaths therefor from solutions of silver

Abstract

A method for leaching valuable metals from ore or one or more minerals that do not oxidise easily and can be reduced, comprises reducing the ore or one or more minerals in contact with an acid medium with complexing agents for sulphur and/or ferrous ions, by means of a reducing agent or in the cathode compartment of an electrolytic chamber that promotes the production of one or more mineral phases containing metals in a reduced form.

IPC Classes  ?

• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C22B 15/00 - Obtaining copper
• C22B 11/00 - Obtaining noble metals
• C25C 1/12 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of copper
• C25C 1/20 - Electrolytic production, recovery or refining of metals by electrolysis of solutions of noble metals

Abstract

The present invention aims to demonstrate that a solublepharmaceutical formulation can be prepared of N,N'-Diamino -diphenyl sulfone which is useful in the development of an idealdrug for use against cerebral infarction, epilepsy, traumatic spinalcord injury, cranio-encephalic trauma, leprosy, Pneumocystiscarinii infections and any condition which requires rapid andcomplete absorption of the compound. As a representative exampleof this application, the dissolution of N,N'-Diamino-diphenylsulfone was evaluated as a neuroprotector in a model of acutecerebral infarction in rats. In this study, N,N'-Diamino-diphenylsulfone showed significant prevention of brain damage, withoutpresenting adverse effects in animals. It is also shown that thesoluble pharmaceutical formulations prepared in this mannerproduce peak blood levels 30 minutes from oral administration andimmediately via the intravenous route.

IPC Classes  ?

• A61K 31/10 - SulfidesSulfoxidesSulfones
• C07C 317/32 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
• C07C 317/34 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring

Abstract

The object of the present invention is to demonstrate that it is possible to prepare a soluble pharmaceutical form of N,N'-diaminodiphenyl sulphone that can be used to produce an optimum drug for use against cerebral infarction, epilepsy, traumatic lesion of the spinal column, cranial-encephalic lesion, leprosy, Pneumocystis carinii infections, and any condition requiring rapid and complete absorption of the compound. As a representative example of this use, a solution of N,N'-diaminodiphenyl sulphone was evaluated as neuroprotector in an acute cerebral infarction model in rats. In this study, N,N'-diaminodiphenyl sulphone demonstrated significant prevention of cerebral damage without exhibiting adverse effects in the animals. It was also demonstrated that the soluble pharmaceutical forms prepared from this form produce maximum blood concentrations 30 minutes after oral administration and immediately after intravenous administration.

IPC Classes  ?

• A61K 31/10 - SulfidesSulfoxidesSulfones
• C07C 317/32 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
• C07C 317/34 - SulfonesSulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring

Abstract

The purpose of the present invention is to demonstrate that semiconducting and non-biodegradable implants made with polypyrrole and polyethylenglycol copolymers and iodine-doped and plasma-synthesized pyrrole polymers, have a neuroprotector effect and induce the reconnection of the spinal cord after an injury; this effect was proved in a model involving a complete section of the spinal cord in rats; the results o the functional evaluation demonstrated 5 times greater recovery in animals implanted with the polypyrrole-polyethylenglycol copolymer compared with the control group which only underwent a complete section of the spinal cord; in addition, the functional recovery of the group with iodine-doped polypyrrole was ten times greater compared to the control group; in the histological study various inflammatory and immune cells were identified at the injury site in the three experimental groups with and without implants and the integration of the polymers in the nervous tissue of the spinal cord was also observed; finally, no respiratory, renal or skin infections, adverse effects or rejection of the biomaterials were found in any of the animals.

IPC Classes  ?

• A61F 2/02 - Prostheses implantable into the body

Abstract

The invention is related to a sol-gel nanostructured titania reservoir and its synthesis which is biocompatible with brain tissue. The pore size distribution, crystallite size and the extent of the crystalline phase distribution of anatase, brookite and rutile can be fully controlled. This device may be used to contain neurological drugs. It may be inserted directly into brain tissue for the purpose of the controlled time release of drugs over a period of from 6 months to three years.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61F 13/00 - Bandages or dressingsAbsorbent pads
• C22C 14/00 - Alloys based on titanium
• C22C 29/00 - Alloys based on carbides, oxides, borides, nitrides or silicides, e.g. cermets, or other metal compounds, e. g. oxynitrides, sulfides

Abstract

The present invention relates to the development of a method for obtainment from amaranth grain of albumin 1 and globulin hydrolysate fractions containing peptides having antihypertensive activity as evaluated by the IC50 value thereof. Different fractions may be obtained from the hydrolysate depending on the degree of purity required. The process may be stopped at any stage of the procedure ensuring that it contains antihypertensive proteins. Nevertheless it is preferable to obtain 0.55 kDa peptide fractions for albumin 1 and 0.4 kDa for globulin. The process is simple and solely involves extraction of the proteins from amaranth grain utilising 0.04 M sodium sulphate solution, and subsequent separation of albumin 1 and globulin through the difference in solubility thereof in water. Hydrolysis of these proteins is realised by alcalase for 15 or 18 h for albumin 1 and globulin, respectively. The hydrolysate obtained may be used from this moment onwards or, if preferred, the hydrolysate fractions containing antihypertensive peptides may be purified to the desired degree of purity, ensuring that the fraction conserves antihypertensive activity evaluated in terms of the IC50 value thereof.

IPC Classes  ?

• A61K 36/21 - Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
• A61P 9/12 - Antihypertensives

Abstract

Methods and systems for analysing the operation of a cochlear stimulation system. An audio stimulus is generated to make the cochlear stimulation system operate. During the operation the intracochlear electrodes generate signals within the auditory nervous system. The response of the patient's nervous system may be measured as an electrical cochlear response ('ECR'). The ECR may be detected and analysed for adaptation, calibration, operational evaluation and fault detection of the patient's cochlear implant. Furthermore the example methods may be utilised to estimate the audiometric thresholds of the implanted patient without his knowledge.

IPC Classes  ?

• A61B 5/12 - Audiometering

Abstract

The invention relates to the mining industry and is intended for the recovery of silver and gold values from solutions resulting from the leaching of mined materials. The reactor includes: a cathodic compartment with a first three-dimensional stainless steel electrode, in which compartment a reaction is performed comprising the electro-reduction of the Ag(I) and Au(I) values dissolved in a leaching liquor; and an anodic compartment in which an oxidation reaction is performed, with the energy used in both compartments being jointly harnessed and said compartments being separated by an anionic membrane. The nature and configuration of the cathode can be used to generate powder deposits that leave the reactor under the effect of the velocity of the fluid, thereby enabling the process to be operated continuously without the reactor being opened. The reactor also includes stainless steel plates for supporting the electrodes, which enable the electric current to be distributed uniformly over the meshes, and a pair of flow distribution channels for discharging the electro-generated metal powders.

IPC Classes  ?

• C25C 5/00 - Electrolytic production, recovery or refining of metal powders or porous metal masses
• C25C 7/02 - ElectrodesConnections thereof

Abstract

An improved process for leaching and recovering precious metals from materials and ores containing same by using ammoniacal thiosulphate solutions of copper with added EDTA, and performing direct selective electroseparation thereof from said solutions. The remaining solution can be recirculated to the leaching step and the resulting yields are similar to those achieved with fresh solutions, meaning that the composition of the solution does not become significantly inferior as a result of the electroseparation process. Said improved process provides enhanced metal recovery efficiency and yields relative to known processes.

IPC Classes  ?

• C22B 11/00 - Obtaining noble metals
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching
• C22B 3/22 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means
• C22B 3/16 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in organic solutions

Abstract

The purpose of the present invention is to demonstrate that semiconducting and non-biodegradable implants made with polypyrol and polyethylenglycol copolymers and iodine-doped and plasma-synthesised pyrol polymers, have a neuroprotector effect and induce the reconnection of the spinal cord after an injury. This effect was proved in a model involving a complete section of the spinal cord in rats. The results of the functional evaluation demonstrated 5 times greater recovery in animals implanted with the polypyrol-polyethylenglycol copolymer compared with the control group which only underwent a complete section of the spinal cord; in addition, the functional recovery of the group with iodine-doped polypyrol was ten times greater compared to the control group. In the histological study various inflammatory and immune cells were identified at the injury site in the three experimental groups with and without implants and the integration of the polymers in the nervous tissue of the spinal cord was also observed. Finally, no respiratory, renal or skin infections, adverse effects or rejection of the biomaterials were found in any of the animals.

IPC Classes  ?

• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• A61F 2/02 - Prostheses implantable into the body
• A61L 31/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The invention relates to the mining industry and to an electrocatalyst for producing an oxidising agent by means of the partial oxidation of sulphurous compounds, such as formamidine disulphide (FDS) from thiourea (Tu). The inventive material and process are advantageous over the prior art in that they enable efficient partial oxidation of sulphurous compounds without producing any parasitic reactions such as subsequent oxidations or oxygen evolution. The structure of the invention consists of a bimetallic electrocatalyst having a molar ratio of between (0.8 - 1) Pt : (0.012- 0.016) Pb on the surface of the support and the method for preparing same comprises the use of the sol-gel technique using a polymer precursor.

IPC Classes  ?

• H01M 4/92 - Metals of platinum group
• B01J 23/42 - Platinum
• B01J 23/62 - Platinum group metals with gallium, indium, thallium, germanium, tin or lead
• H01M 4/04 - Processes of manufacture in general
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/08 - Heat treatment

Abstract

The invention is related to a sol-gel nanostructured titania reservoir and its synthesis which is biocompatible with brain tissue. The pore size distribution, crystallite size and the extent of the crystalline phase distribution of anatase, brookite and rutile can be fully controlled. This device may be used to contain neurological drugs. It may be inserted directly into brain tissue for the purpose of the controlled time release of drugs over a period of from 6 months to three years.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form