Abstract

The present invention relates to a water (1) filling device for an aquarium (2) comprising a first bent part (3) with a water (1) inlet (31) and a plurality of water (1) outlets (32), the first part (3) comprising a first section (33) and a second section (34) joined by a bend (35), and the device comprises a second part (4) assembled onto the second section (34) of the first part (3). Said second part (4) comprises at least one diffuser channel (41) oriented perpendicular to the at least one water (1) outlet (32). The invention aims to disclose a tool that effectively fills the aquarium (2) without disturbing the life therein, minimising the turbulence generated in the water during the filling process.

IPC Classes  ?

• A01K 63/04 - Arrangements for treating water specially adapted to receptacles for live fish

Abstract

The present invention refers to the use of bacteria present in the oral microbiota of a patient with Eating Disorders (EDs) as diagnostic marker of the presence of vomiting behaviour in the patient. Specifically, the bacteria belong to one or more genera selected from Granulicatella and Actinomyces, and, optionally Bulleidia, Veillonella, Oribacterium, Porphyromonas, Gemella, Campylobacter and Aggregatibacter. Further, the present invention refers to the method for the detection of vomiting behaviour in a patient with EDs, comprising the steps of i) obtaining a saliva sample from the patient, ii) determining the bacteria profile of the saliva sample and comparing to the bacteria profile of a control sample, and iii) detecting whether there are statistically significant differences between both bacteria profiles, attributing such statistically significant differences to a vomiting behaviour. Finally, the invention refers to an in vitro kit adapted to implement the method of the invention.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention discloses the expression levels of CNR1 and GPR55 receptors in peripheral blood mononuclear cells, specifically in circulating CD4+ lymphocytes, as minimally invasive early biomarkers of type 1 diabetes, the early diagnostic method using said biomarkers, and a kit for implementing said method.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The invention discloses biomarkers of metastasis in endometrial cancer and a method for the diagnosis and/or prognosis of metastasis development in endometrial cancer patients, said method being based on the relative abundance of the various genera and species in the isolated microbiota in endometrial samples, and on microRNA expression levels in the endometrial tissue.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

The present invention relates to an extracellular matrix obtained from an EPIC murine cell line, the method of obtaining same and uses in cell cultures.

IPC Classes  ?

• C12N 5/02 - Propagation of single cells or cells in suspensionMaintenance thereofCulture media therefor

Abstract

The present invention relates to a lighting device comprising a plurality of LED diodes (1), installed and distributed on at least one support arm (2), all the LED diodes (1) being oriented towards a single treatment point (3) and the emitted light (8) of said diodes being focused towards said treatment point (3) by means of light-concentrating means (4). In this manner, it is possible to carry out localised treatments of photodynamic therapy, without affecting the healthy surface, adapting the dose to the requirements of the lesioned surface.

IPC Classes  ?

• F21V 21/26 - Pivoted arms
• F21Y 113/13 - Combination of light sources of different colours comprising an assembly of point-like light sources
• F21Y 115/10 - Light-emitting diodes [LED]

Abstract

The invention relates to a photonic biosensor with layer discrimination ability and coherent detection ability, which is formed by a waveguide (100) that simultaneously supports different orthogonal light states (201, 202). These states may be one mode at different wavelengths (205, 206), modes with different polarisations (207, 208), modes of different orders (209, 210) or any combination of same. This allows different measurements to be taken in identical conditions and reduces any interference that may be produced by a variation in temperature or in the concentration of any other component of a sample flowing through a microfluidic channel on the sensor surface. In addition, for the simple and practical implementation of this concept, it is important that the multiplexing (501, 702, 803) and demultiplexing (502, 701, 801) of the states is carried out in an integrated manner on the chip, and that coherent detection (507, 704, 802) is preferably also carried out in an integrated manner in the chip.

IPC Classes  ?

• G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods

Abstract

The present invention relates to a propulsion device for water vehicles that comprises: a watertight compartment (1) housing therein an electric motor connected to a shaft (2), said motor causing an angular oscillating movement in the shaft (2), such that a first end of the shaft protrudes from the compartment (1) through a first hole and a second end of the shaft protrudes from the compartment (1) through a second hole; blades (4) coupled to each end of the shaft (1) by means of respective torsional springs; guides (11) configured to be fastened to the vehicle; guiding elements (10) fastened to the compartment and arranged to be inserted into, and guided along the guides; and a longitudinal spring with varying rigidity and modified by a control unit, with a first end configured to be connected to the vehicle and a second end solidly connected to the compartment (1).

IPC Classes  ?

• B63H 1/36 - Swinging flaps, e.g. fishtail type

Abstract

Massive sequencing panel composed of 37 genes for liquid biopsy that allows the early diagnosis of breast cancer and methods for obtaining useful data for the diagnosis and follow-up of the disease.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates to a composition or combined preparation which comprises L-carnitine and essential oils, specially essential oils from savory (Satureja hortensis), parsley (Petroselinum crispum) and /or rosemary (Rosmarinus officinalis) and uses in the treatment, relief or prevention of diseases, as nutraceutical and / or prebiotic.

IPC Classes  ?

• A61K 36/54 - Lauraceae (Laurel family), e.g. cinnamon or sassafras
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61K 31/205 - Amine addition salts of organic acidsInner quaternary ammonium salts, e.g. betaine, carnitine
• A61K 36/23 - Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61K 36/53 - Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• A23L 29/10 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing emulsifiers
• A23L 33/175 - Amino acids
• A61K 9/107 - Emulsions
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

The invention discloses an energy conversion device comprising a profile (1), a work plate (2) joined by a moment connection to the trailing edge of the profile, a shaft (4) joined to the underside (15) of the profile (1) and a base (10) comprising a fixed part (3) to be anchored to the ground, where a shaft (4) is arranged to be able to move relative to the fixed part (3). The length (22) of the work plate (2) is greater than half of its width, at least 500 times greater than its thickness and greater than 10 times the chord of the profile.

IPC Classes  ?

• F03D 5/00 - Other wind motors
• F03D 3/00 - Wind motors with rotation axis substantially perpendicular to the air flow entering the rotor

Abstract

The present invention relates to a silica mesoporous nanoparticle comprising a covalently bound protein G' or protein A, the composition comprising said nanoparticle, the use thereof for capturing, purifying, eliminating and/or isolating immunoglobulins, preferably IgG, as well as a method for purifying an immunoglobulin, methods for pre-treating samples in order to subsequently diagnose allergies, infections and/or autoimmune diseases in a patient, and said diagnostic methods.

IPC Classes  ?

• C01B 33/12 - SilicaHydrates thereof, e.g. lepidoic silicic acid
• A61K 9/51 - Nanocapsules
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention relates to single-beam side deflectors with effective refractive indexes of respective channel and target film waveguides, a refractive index of the cladding and substrate, and a periodicity Λ of the channel waveguide that satisfy the single-beam diffraction conditions. The invention also relates to wavelength multiplexers/demultiplexers, optical antenna feeders, and methods which use all of them.

IPC Classes  ?

• G02F 1/313 - Digital deflection devices in an optical waveguide structure

Abstract

The present invention relates to a device for intraoperatively disinfecting a bone prosthesis (7) using bioelectric effect. Advantageously, the device comprises an array (1) that can be adapted to the shape of the bone prosthesis (7), wherein the array (1) is provided with an arrangement of electrodes (2) designed to connect to a programmable controller (11) for supplying current, designed to perform a bioelectric treatment on the prosthesis (7). The invention also relates to a disinfection system comprising the device connected to the programmable controller (11) for supplying current, and to a method for activating same.

IPC Classes  ?

• A61L 2/03 - Electric current, e.g. electrolysis

Abstract

in vitroin vitro methods, and kits or devices, for predicting immunotherapy response using anti-PD1 and/or anti-PD-L1 immune checkpoint inhibitors and the clinical benefit for a human subject with metastatic cutaneous melanoma.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention relates to a shock absorber (1) for vehicles comprising a cylinder (2) with a longitudinal shaft (LS) filled with a non-Newtonian shear thickening fluid (STF) along which a plunger (3) moves longitudinally. The cross-section of the plunger (3) is smaller than an inner cross-section of the cylinder (2) to allow the STF to pass through a space between said plunger (3) and an inner wall of the cylinder (2). Furthermore, the plunger (3) is configured such that the resistance offered by the STF against the movement of the plunger (3) along a first direction of movement is different from the resistance offered by the STF against the movement of the plunger (3) along a second direction of movement opposite to the first.

IPC Classes  ?

• F16F 9/53 - Means for adjusting damping characteristics by varying fluid viscosity, e.g. electromagnetically
• F16F 9/516 - Special means providing automatic damping adjustment resulting in the damping effects during contraction being different from the damping effects during extension
• F16F 9/512 - Means responsive to load action on the damper or fluid pressure in the damper

Abstract

The present invention relates to the use of the soluble receptor sIFNAR2 in the treatment of SARS-CoV-2 coronavirus infection, and compositions comprising said protein.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.

IPC Classes  ?

• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
• G02B 5/18 - Diffracting gratings
• G02B 6/028 - Optical fibres with cladding with core or cladding having graded refractive index

Abstract

A bricked sub-wavelength periodic waveguide and a modal adapter, power divider and polarization splitter that use the waveguide. The waveguide includes blocks disposed periodically with a period “Lz” on a substrate and which alternate with a covering material. The first blocks have a width “ax” and the second blocks have a width “bx”, alternating on the substrate according to a period “Lx”, the second blocks being shifted a distance “dz” the first blocks in the direction of propagation. A modal adapter, a power divider and a polarization splitter all use the periodic waveguide and can operate with larger wave periods without leaving the sub-wavelength regime.

IPC Classes  ?

• G02B 5/18 - Diffracting gratings
• G02B 5/30 - Polarising elements
• G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
• G02B 6/24 - Coupling light guides

Abstract

The present invention refers to an in vitro method for the diagnosis and/or prognosis of multiple sclerosis.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

GAL(1-15) and analogues thereof for use in the prevention and/or treatment of alcohol-related effects and disorders. The present invention relates to the use of galanin(1-15), which has the general formula Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala (GWTLNSAGYLLGPHA)(SEQ ID NO: 1), or an analogue thereof, or pharmaceutically acceptable salt, ester, tautomer, solvate, or hydrate thereof, or a pharmaceutical composition or kit comprising any of same, for use in the prevention and/or treatment of alcohol-related effects and disorders, especially the use thereof to reduce alcohol consumption.

IPC Classes  ?

• A61K 38/22 - Hormones
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 39/02 - Antidotes

Abstract

The invention relates to a solar-powered water desalination and condensation structure for floating desalination systems, characterised in that it has an essentially inverted cone-shaped or pyramid-shaped geometry, the upper portion of which projects outwards and the lower portion of which is hollow and open so that water rises and enters, contributing to the buoyancy and to the generation and maintenance of a temperature gradient; said structure comprising: (i) a plurality of solar collectors arranged in an inclined fashion and radially on the inner wall of the geometry; (ii) a plurality of evaporator elements connected at the lower ends of the solar collectors, the free ends of which come into contact with the water entering through the lower portion of the structure; and (iii) a collecting pipe that connects with the lower portion of the structure in order to collect the desalinated condensed water.

IPC Classes  ?

• C02F 1/14 - Treatment of water, waste water, or sewage by heating by distillation or evaporation using solar energy
• B63B 35/44 - Floating buildings, stores, drilling platforms, or workshops, e.g. carrying water-oil separating devices

Abstract

Disclosed are a cell therapy product for the treatment of sphincter dysfunctions, a production method and medical uses.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

Stringed instrument with bimodal operation. The present invention relates to a musical instrument, in particular an instrument used in string quartets, wherein the violin is the most representative example, having bimodal operation and provided with a sound-capturing module, a preamplifier and communications module, a signal-receiving module and a power module. This instrument allows the player to obtain the same sound and sensation as when playing a classical violin, but also includes the possibility of wirelessly sending the sound to a receiver that can connect to an amplifier, a mixing console, a recording system, a signal-processing system, streaming systems, etc., thereby providing all the options of an electric violin.

IPC Classes  ?

• G10H 3/18 - Instruments in which the tones are generated by electromechanical means using mechanical resonant generators, e.g. strings or percussion instruments, the tones of which are picked up by electromechanical transducers, the electrical signals being further manipulated or amplified and subsequently converted to sound by a loudspeaker or equivalent device using mechanically actuated vibrators with pick-up means using strings, e.g. electric guitars
• H04R 1/46 - Special adaptations for use as contact microphones, e.g. on musical instrument, on stethoscope

Abstract

The present invention relates to a lighting device comprising a plurality of LED diodes (1), installed and distributed on at least one support arm (2), all the LED diodes (1) being oriented towards a single treatment point (3) and the emitted light (8) of said diodes being focussed towards said treatment point (3) by means of light-concentrating means (4). In this manner, it is possible to carry out localised treatments of photodynamic therapy, without affecting the surface.

IPC Classes  ?

• A61N 5/06 - Radiation therapy using light

Abstract

The present invention relates to the use of a specific insulin-like growth factor 2 (IGF-2) receptor agonist for the treatment of Parkinson's disease and the disorders associated with Parkinsonism. The invention further relates to compositions that comprise a specific IGF-2 receptor agonist and a compound suitable for the treatment of a disease associated with the formation of amyloid deposits, and to the medical uses of said composition. The invention further relates to an in vitro method for identifying a compound suitable for the treatment and/or prevention of Parkinson's disease and the disorders associated with Parkinsonism.

IPC Classes  ?

• C07K 14/65 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
• A61K 38/30 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
• A61P 25/16 - Anti-Parkinson drugs

Abstract

An integrated mode converter and multiplexer (/demultiplexer) combines a multimode interference coupler, at least one phase-shifter and a symmetrical Y-junction. The dispersion of the multimode interference coupler is engineered through subwavelength structures in order to achieve a very wide bandwidth. Several phase-shifter topologies for further bandwidth enhancement are disclosed, as well as architectures for multiplexing a greater number of optical modes.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/124 - Geodesic lenses or integrated gratings
• G02B 6/125 - Bends, branchings or intersections
• G02B 6/14 - Mode converters
• G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
• G02B 6/34 - Optical coupling means utilising prism or grating
• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
• G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
• G02F 1/225 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference in an optical waveguide structure
• G02B 6/122 - Basic optical elements, e.g. light-guiding paths

Abstract

This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevention of disorders, diseases or conditions responsive to the stimulation of the ghrelin receptor in a subject in need thereof. In particular, for the treatment and/or prevention of disorders responsive to the positive modulation (stimulation) of the ghrelin receptor, such as diabetes, obesity-related disorders, and, most preferably, for treating or preventing age related conditions or diseases such as by promoting appetite, inhibiting insulin secretion and lowering insulin resistance, increasing growth hormone release, enhancing muscle vitality or fragility and treating or preventing sarcopenia by increasing net muscle mass, improving cognition (and/or treating or preventing diseases such as Azlheimer's disease, vascular dementia, Parkinson's Disease, and Huntington's disease) and treating or preventing age related hypertension.

IPC Classes  ?

• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates

Abstract

Disclosed are: biomarkers and a method for the prediction or prognosis of the response to treatment with BRAF inhibitors and MEK inhibitors (BRAFi + MEKi) in patients with mutated BRAF metastatic melanoma; a kit or device; and the uses thereof.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The invention relates to single-beam side deflectors with effective refractive indices of respective channel and target film waveguides, cover and substrate refractive indices, and channel waveguide periodicity that meet single-beam diffraction conditions. The invention also relates to wavelength multiplexers/demultiplexers, optical antenna feeders, and methods that use all of them.

IPC Classes  ?

• G02F 1/31 - Digital deflection devices
• G02B 5/18 - Diffracting gratings
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/34 - Optical coupling means utilising prism or grating

Abstract

The present invention relates to compositions, methods and uses, consisting of a functionalised miRNA-based nanosystem for treating obesity, weight loss and/or reduction of localised fat, which comprises miR-21 or other derived or equivalent compounds such as modified polynucleotides, synthetic mimetic and/or isomiR of miR-21; and a carrier which comprises an optimised nanoparticle for effectively binding oligonucleotides, forming an adequate nanosystem for in vivo transfection and, in particular, for the in vivo release of genes in fatty tissue.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A method for predicting or prognosticating the response of individuals with multiple sclerosis to treatment with IFNβ, kit or device, and uses.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

in vitroin vitroin vitro method for monitoring the response to such treatment.

IPC Classes  ?

• A61K 38/33 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
• A61K 38/22 - Hormones
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

Disclosed are a bricked sub-wavelength periodic waveguide and a modal adapter, power divider and polarisation splitter that use said waveguide. The waveguide (600) comprises blocks (601, 602) disposed periodically with a period "Lz" on a substrate (603) and which alternate with a covering material (604). The first blocks (601) have a width "ax" and the second blocks (602) have a width "bx", alternating on the substrate (603) according to a period "Lx", the second blocks (602) being displaced a distance "dz" the first blocks (601) in the direction of propagation. Also disclosed are a modal adapter (1100), a power divider (1200) and a polarisation splitter (1500) that all use the periodic waveguide (600) and can operate with larger wave periods without leaving the sub-wavelength regime.

IPC Classes  ?

• G02B 5/18 - Diffracting gratings
• G02B 5/30 - Polarising elements
• G02B 6/24 - Coupling light guides

Abstract

Disclosed is an artificial ventilator especially designed to allow quick production and with readily available components which, at the same time, maintains robust operation compatible with the treatment of patients with acute respiratory failure.

IPC Classes  ?

• A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
• A61H 31/00 - Artificial respiration by a force applied to the chestHeart stimulation, e.g. heart massage

Abstract

The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving an independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. This document also describes a manufacturing method of said waveguide which allows the birefringence of the light that passes through the waveguide.

IPC Classes  ?

• G02B 6/028 - Optical fibres with cladding with core or cladding having graded refractive index
• G02B 5/18 - Diffracting gratings
• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems

Abstract

linkerlinker (maleimide), D is a dendrimer (PAMAM), and B is a beta-lactam antibiotic.

IPC Classes  ?

• B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C07D 205/08 - Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
• C08G 73/02 - Polyamines
• C07C 43/13 - Saturated ethers containing hydroxy or O-metal groups

Abstract

A metal-adsorbing composite material based on magnetic graphene oxide and method for obtaining same. A metal-adsorbing composite material based on magnetic graphene oxide and method for obtaining same. The present invention relates to a metal-adsorbing composite material comprising: a hybrid material comprising either coated magnetic nanoparticles modified with amino groups and/or hydroxyl groups on their surface, coupled to graphene oxide by physical forces and amide- or ester-like covalent bonds; said magnetic graphene oxide activated by the introduction of acid groups; and/or an alkylpolyamine to which said activated magnetic graphene oxide is attached by covalent bonding; and a ligand comprising a chelating functional group, said ligand being attached to the hybrid material by said alkylpolyamine. The invention also relates to the method for obtaining said composite material and use thereof in the decontamination and treatment of spills.

IPC Classes  ?

• C01B 32/198 - Graphene oxide
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

Disclosed is a Double-cavity receiver for linear-focus collectors, characterised in that it comprises a concave metallic absorber (2) delimited at the opening thereof by a slit that has width (d) and is covered by an oval lens (8), the absorber and the lens (8) limiting a main cavity (4) below which, in the direction of a reflector of the collector, is located a second cavity (7) subjected to vacuum and delimited by a concave glass piece (10), formed by multiple sections in the form of inverted arches of variable thicknesses, the outlines of which follow a pattern defined by continuous and derivable piecewise polynomial functions. The double-cavity receiver thus provided has optical and thermal advantages.

IPC Classes  ?

• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 23/74 - Arrangements for concentrating solar rays for solar heat collectors with reflectors with trough-shaped or cylindro-parabolic reflective surfaces
• F24S 23/30 - Arrangements for concentrating solar rays for solar heat collectors with lenses

Abstract

Disclosed is a linear-focus solar collector with a horseshoe-shaped open receiver, which is a new solar collector concept for linear-focus solar thermal systems that allows the design of a more robust receiver that is durable under operating conditions at moderate temperate (<300ºC). A concave metal absorber, the upper front side of which is covered by a thermal insulating material, encloses a cavity with air at atmospheric pressure. The opening of the cavity is limited with a piece of glass. This piece of glass can be partially or fully closed, allowing the existence of a stratification chamber that limits convective losses. In addition to thermal functionality, the glass piece is optically active, improving the interception index of a slit through which the rays access the metallic absorber.

IPC Classes  ?

• F24S 23/74 - Arrangements for concentrating solar rays for solar heat collectors with reflectors with trough-shaped or cylindro-parabolic reflective surfaces
• F24S 20/20 - Solar heat collectors for receiving concentrated solar energy, e.g. receivers for solar power plants
• F24S 23/30 - Arrangements for concentrating solar rays for solar heat collectors with lenses

Abstract

The invention relates to an integrated filter based on coupled resonators, which comprises an inlet waveguide (1), an outlet waveguide (7), a plurality of Bragg reflectors (5), a plurality of Fabry-Perot cavities (6), two modal converters (2) and a plurality of adapters (4). The two modal converters (2) vary adiabatically between a first width (w1) and a second width (w2), while the plurality of adapters (4) connect the plurality of Bragg reflectors (5) to the plurality of Fabry-Perot cavities (6) and to the two modal converters (2), by means of alternating sections with at least two different effective indices. The second width (w2) of the plurality of Bragg reflectors (5) and the associated forbidden band thereof help to optimise the device with respect to other solutions based on narrow guides and/or weak gratings, thereby improving the performance of the integrated filter.

IPC Classes  ?

• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 5/28 - Interference filters

Abstract

Biomarkers, in vitro methods and kit or dispositive of predicting or prognosticating the response of a human subject to anti-PD1 and/or anti PD-L1 immune checkpoint inhibition immunotherapy.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The invention describes a construction node (1) for 2D or 3D structures, which is characterised in that it comprises: a central plate (2) comprising a plurality of through-slots (21) that are essentially perpendicular to the radial direction of the central plate (2); and a plurality of connectors (3) comprising a proximal portion (31) and a flat distal portion (32) that essentially form a right angle with one another, wherein the proximal portion (31) has a proximal hole (33) for the rotary coupling thereof to the through-slots (21) of the central plate (2), and the distal portion (32) has a distal hole (34) for the rotary coupling thereof to bars (100) of the 2D or 3D structure (200).

IPC Classes  ?

• E04B 1/32 - Arched structuresVaulted structuresFolded structures

Abstract

This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevention of disorders, diseases or conditions responsive to the stimulation of the ghrelin receptor in a subject in need thereof. In particular, for the treatment and/or prevention of disorders responsive to the positive modulation (stimulation) of the ghrelin receptor, such as diabetes, obesity-related disorders, and, most preferably, for treating or preventing age related conditions or diseases such as by promoting appetite, inhibiting insulin secretion and lowering insulin resistance, increasing growth hormone release, enhancing muscle vitality or fragility and treating or preventing sarcopenia by increasing net muscle mass, improving cognition (and/or treating or preventing diseases such as Azlheimer's disease, vascular dementia, Parkinson's Disease, and Huntington's disease) and treating or preventing age related hypertension.

IPC Classes  ?

• A61K 31/075 - Ethers or acetals
• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

This invention relates to the delivery of a composition, preferably a pharmaceutical composition, comprising D-pinitol, D-Chiro inositol or myo-inositol or any pharmaceutically acceptable salt thereof, for use in the treatment or prevention of disorders, diseases or conditions responsive to the stimulation of the ghrelin receptor in a subject in need thereof. In particular, for the treatment and/or prevention of disorders responsive to the positive modulation (stimulation) of the ghrelin receptor, such as diabetes, obesity-related disorders, and, most preferably, for treating or preventing age related conditions or diseases such as by promoting appetite, inhibiting insulin secretion and lowering insulin resistance, increasing growth hormone release, enhancing muscle vitality or fragility and treating or preventing sarcopenia by increasing net muscle mass, improving cognition (and/or treating or preventing diseases such as Azlheimer's disease, vascular dementia, Parkinson's Disease, and Huntington's disease) and treating or preventing age related hypertension.

IPC Classes  ?

• A61K 31/05 - Phenols
• A61K 31/075 - Ethers or acetals
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/06 - Antihyperlipidemics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 5/06 - Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 9/12 - Antihypertensives
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents
• A61K 8/34 - Alcohols

Abstract

The invention relates to a system for controlling access to an area (1), together with the associated method, with: an identification device (3) for identifying access (2) in the coverage area of a wireless communication network (4); remote opening means (33) connected to control means (5) for controlling the area (1); graphic signalling means (31); and a mobile device (6) with capturing means (61) for capturing signals (32), wherein the control means (5) for controlling the area (1) are configured to activate the remote opening means (33) if the mobile device (6) is connected to the wireless communication network (4), and to determine whether the capturing means (61) have captured at least one graphic symbol (32a) from the identification device (3), thereby obtaining a simplified, automatic area access system with lower implementation costs, without anyone needing to intervene in the operation thereof.

IPC Classes  ?

• H04W 12/06 - Authentication

Abstract

c1c2Rc1Rc2Rxc1Rc1Rc1(R). Lastly, the resistor R is estimated from the values of the calibration resistors and the discharge times obtained, with a considerable reduction in the measuring time used.

IPC Classes  ?

• G01R 27/02 - Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid

Abstract

The invention relates to an integrated polarisation splitter based on a sub-wavelength multimode interference coupler (110), in other words, a multimode interference coupler (110) with an anisotropic multimode waveguide region formed by a plurality of sections of core material (210) and a plurality of sections of a cladding material (230) alternately arranged in a periodic way, with a period (Λ) smaller than the wavelength of a light propagated through said anisotropic region. The core material sections (210) are rotated an angle (α) greater than zero with respect to a perpendicular with an input waveguide (120) to increase the anisotropic character of the multimode waveguide region.

IPC Classes  ?

• G02B 6/126 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind using polarisation effects
• G02B 5/18 - Diffracting gratings
• G02B 6/028 - Optical fibres with cladding with core or cladding having graded refractive index
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals

Abstract

The present invention falls within the field of instrumentation for measurement using spectrometry techniques, and specifically, measurement in the field when the sample (10) or the measuring instrument (12) are subjected to mechanical fluctuations. Thus, the invention relates to a system (1) and a method for improving the signal generated by optical spectrometry instruments and makes it possible to obtain a series or a succession of optical signals with spectral information, emitted from the same point of a sample (10) at a distance from the measuring instrument (12). By linking a series of spectral data associated with a single point of the sample (10) it is possible, among other things, to exclude interference in the measurement caused by information coming from other points of the sample (10), and to improve the detection limit associated with the precision of the measurement, by accumulating individual measurements emitted from a single point of the sample (10).

IPC Classes  ?

• G01J 3/28 - Investigating the spectrum
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details

Abstract

The invention relates to a method for identifying a compound with potential pesticide activity against an organism containing chitin, the compound being an inhibitor of chitin deacetylase (CDA). The method comprises cheminformatics and experimental approximations that include molecular topology equations to examine the experimental chemical and analysis databases of the identified compounds to test their activities as pesticides. More specifically, the invention relates to the experimental analysis of a set of 20 compounds and their use as fungicides, arthopocides and/or nematicides. In addition, the specificity of these compounds as CDA inhibitors was confirmed using enzyme inhibition testing and docking. The method of the invention is useful for identifying CDA inhibitors useful as agricultural fungicides or for controlling other pests such as insects or nematodes that are harmful for crops and/or mammals.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction

Abstract

in vivoin vivo release of genes in fatty tissue.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient

Abstract

Method for the prediction or prognosis of developing rheumatoid arthritis; Method for predicting or prognosing the probability of an individual of suffering diseases related to the immune system, and preferably related to the development of rheumatoid arthritis; diagnostic kit or device and uses thereof.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• A61K 35/74 - Bacteria

Abstract

A method for predicting or prognosticating the response of individuals with multiple sclerosis to treatment with INF-beta, which comprises measuring serum levels of sIFNAR2, the soluble isoform of the INF-beta receptor.

IPC Classes  ?

• C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving enzymes not classifiable in groups

Abstract

The invention relates to RRM2B as a therapeutic target in the treatment of Alzheimer's disease. In particular, the present invention relates to the inhibition of the RRM2B gene, or of the activity of the enzyme coded by same, for use in the treatment of Alzheimer's disease.

IPC Classes  ?

• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The invention relates to a device (100), system and method for controllable fastening using a mechanical arm (200), wherein the device (100) comprises at least two foldable levers (110) joined together by means of a shaft (130) and by means of at least one elastic element (140). The foldable levers are configured to rotate relative to the shaft (130) between a first position and a second position when pressed by the mechanical arm (200). In the first position, the elastic element (140) is located at a first side of the shaft (130), such that the tension of the elastic element (140) presses the foldable levers (110) against the mechanical arm (200). In the second position, the elastic element (140) is located at a second side of the shaft (130), such that the tension of the elastic element (140) keeps the foldable levers (110) in the second position, without making contact with the mechanical arm (200), and securing means fasten the device (100) to a body (300).

IPC Classes  ?

• B25J 15/04 - Gripping heads with provision for the remote detachment or exchange of the head or parts thereof
• B25J 15/06 - Gripping heads with vacuum or magnetic holding means
• F16B 2/10 - Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening external, i.e. with contracting action using pivoting jaws
• A44C 5/12 - C-spring-type bracelets or wrist-watch holders
• G09F 3/00 - Labels, tag tickets, or similar identification or indication meansSealsPostage or like stamps
• B64D 1/02 - Dropping, ejecting, or releasing articles
• B64C 39/02 - Aircraft not otherwise provided for characterised by special use

Abstract

The invention relates to a waveguide and a polarisation splitter based on said waveguide, in which a rotation of an angle greater than zero is applied to a plurality of sections of a core material and a plurality of sections of a covering material, thereby achieving independent control of the refractive indices of a zero-order transverse electric mode and a zero-order transverse magnetic mode. The invention also relates to a method for producing said waveguide, which allows the birefringence of the light that passes through the waveguide to be modified.

IPC Classes  ?

• G02B 6/126 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind using polarisation effects
• G02B 6/124 - Geodesic lenses or integrated gratings

Abstract

The invention relates to a goniometer that enables precise marking of the desired ocular axis in the phase immediately after surgery for the treatment of astigmatism. It essentially consists of two circular, transparent discs, one of which is at least axially stationary, in which the angles from 0º to 180º are marked, which are aligned with the angles from 0º to 180º of the patient's eye; and the other one of which is movable both angularly and axially, with a reference mark (9) and moving rigidly connected to a marking part (12), impregnated with die, which is responsible for marking the eye. Not only does the device make it possible to carry out said marking in a precise and comfortable manner, it also makes it possible to measure the angle of toric lenses already implanted.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61F 9/007 - Methods or devices for eye surgery
• A61F 2/16 - Intraocular lenses

Abstract

The present invention provides a novel method to isolate and expand pure neural stem cells (NSCs) from cerebrospinal fluid (CSF) of premature babies with Intraventricular haemorrhage, which produces a population enriched in NSC-CSF cells free of contaminating fibroblasts and other cell types. The present invention also includes substantially pure populations of CSF-NSC cells, and their use to treat and prevent diseases and injuries, including Intraventricular haemorrhage and post- hemorrhage hydrocephalus/developmental deficits.

IPC Classes  ?

• C12N 5/0797 - Stem cellsProgenitor cells

Abstract

The invention relates to an integrated polarisation splitter based on a sub-wavelength multimode interference coupler (110), in other words, a multimode interference coupler (110) with an anisotropic multimode waveguide region formed by a plurality of sections (210) of a core material and a plurality of sections (230) of a cladding material that periodically alternate with a period (Λ) smaller than the wavelength of light propagated through said anisotropic region. The core material sections (210) are rotated by an angle (α) greater than zero with respect to a perpendicular to an input waveguide (120) in order to increase the anisotropic character of the multimode waveguide region.

IPC Classes  ?

• G02B 6/126 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind using polarisation effects
• G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
• G02B 5/18 - Diffracting gratings

Abstract

The invention relates to new pirazolone compounds, to the use thereof for the diagnosis of allergies to beta-lactam antibiotics, preferably aminocephalosporins and/or aminopenicillins, and to a method for preparing same.

IPC Classes  ?

• C07D 241/24 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 31/4965 - Non-condensed pyrazines
• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention belongs to the fields of molecular biology and biomedicine, and more specifically to the field of proctology in relation to the diagnosis, prognosis and treatment of colorectal cancer. An association has been established between this type of cancer and a methylation signature associated with the ZNF543 gene in possible association with ZNF397OS and/or TMEM106A in patients with different degrees of obesity, opening the possibility of new tools for diagnosis and prognosis and personalised therapies.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

GAL(1-15) and analogues thereof for use in the prevention and/or treatment of alcohol-related effects and disorders. The present invention relates to the use of galanin(1-15), which has the general formula Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu- Gly-Pro-His-Ala, or GWTLNSAGYLLGPHA, or an analogue thereof, or pharmaceutically acceptable salt, ester, tautomer, solvate or hydrate thereof, or a pharmaceutical composition or kit comprising any of same, for use in the prevention and/or treatment of alcohol-related effects and disorders, especially the use thereof to reduce alcohol consumption.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 25/32 - Alcohol-abuse

Abstract

Use of the compound Ki16425 for preventing, relieving, improving and/or treating alcohol-related mental and behavioural disorders, including harmful or high-risk use, alcohol intoxication or pathological drunkenness, alcohol dependence syndrome or alcohol withdrawal syndrome, and alcohol addiction (alcoholism).

IPC Classes  ?

• A61K 31/42 - Oxazoles
• A61P 25/32 - Alcohol-abuse
• C07D 261/16 - Benzene-sulfonamido isoxazoles

Abstract

An integrated mode converter and multiplexer (/demultiplexer) is disclosed, which combines a multimode interference coupler (100), at least one phase-shifter (200) and a symmetrical Y-junction (300). The dispersion of the multimode interference coupler (100) is engineered through subwavelength structures in order to achieve a very wide bandwidth. Several phase-shifter (200) topologies for further bandwidth enhancement are disclosed, as well as architectures for multiplexing a greater number of optical modes.

IPC Classes  ?

• G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
• G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
• G02B 6/125 - Bends, branchings or intersections
• G02B 6/14 - Mode converters

Goods & Services

Printers' type; Printing blocks; Printing fonts; Typeface.

Goods & Services

Printers' type; Printing blocks; Printing fonts; Typeface.

Abstract

Pharmaceutical composition comprising selective serotonin and galanin (1-15) reuptake inhibitors. The present invention relates to the use of galanin (1-15) or a pharmaceutically acceptable salt thereof for use in combination with a selective serotonin reuptake inhibitor or any other compound that significantly increases the synthesis of postsynaptic 5-HT1A receptors in terminal areas. In particular, the present invention concerns the use of galanin (1-15) or a pharmaceutically acceptable salt thereof useful for increasing and/or providing a faster onset of the therapeutic effect of a selective serotonin reuptake inhibitor or any other compound that significantly increases the synthesis of postsynaptic 5-HT1A receptors in terminal areas.

IPC Classes  ?

• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61P 25/24 - Antidepressants

Abstract

The invention describes a device (1) for controlling the vibration applied to fruit trees by a vibration machine (100) actuated by a motor (101), which comprises: a control means (2) designed to connect to the vibration machine (100), for affecting the speed of the motor (101), such that the frequency of the vibration applied to the tree (200) coincides with the natural resonance frequency of the tree (200); at least one vibration sensor (3) designed to obtain information in real time concerning the response of the tree (200) to the vibration applied; and a processing means (4) connected to the control means (2) and to the vibration sensor (3), which is designed to manage the operation of said control means (2) and vibration sensor (3).

IPC Classes  ?

• A01D 46/26 - Devices for shaking trees or shrubsFruit catching devices to be used therewith

Abstract

The authors of the present invention describe compounds derived from or structures related to clavulanic acid and the medical uses thereof. The invention also relates to a composition, a dosage form, a kit or device, and the uses of same.

IPC Classes  ?

• C07C 53/122 - Propionic acid
• C07C 53/124 - Acids containing four carbon atoms
• A61K 31/185 - AcidsAnhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids

Abstract

The tool coupling comprises a first tool part (4) and a second tool part (14), the second tool part (14) being movable in relation to the first tool part (4),. The tool coupling comprises a first base part (6) for detachably retaining the first tool part (4) and a second base part (16) movable in relation to the first base part (6) for detachably retaining the second tool part (14). The first base part (6) comprises a pusher (11) movable in relation to the first base part (6) for detaching the first tool part (4) and the second base part (16) comprises a cap (21) movable in relation to the second base part (16) for detaching the second tool part (14).

IPC Classes  ?

• B25J 15/04 - Gripping heads with provision for the remote detachment or exchange of the head or parts thereof
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

A surgical robotic system (1) comprising: robotic units, each one being independent from the others, each comprising a support (11) and a robotic arm assembly (12); said support (11) comprising motion means and configured to change position and orientation of the support (11) with respect to the table (3); said robotic arm assembly (12) comprising: a robotic arm (15), a surgical tool (18) coupled thereto and a force sensor (16) configured to receive measurement of forces and torques applied by the tool (18). The system also comprises a control console (7) configured to remotely operate said robotic units, comprising: computing means (42); haptic devices (8) configured to control the movement, spatial orientation and aperture/ closure of the distal end of the tool (18), each haptic device (8) being configured to control one robotic arm (15); selection means (51) configured to activate/deactivate the robotic arms (15); a monitor (701) configured to show a 3D image.

IPC Classes  ?

• A61B 34/30 - Surgical robots
• A61B 34/37 - Leader-follower robots
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• B25J 9/00 - Programme-controlled manipulators
• B25J 13/02 - Hand grip control means
• B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators

Abstract

The invention relates to a method for handling a robotic system for minimally invasive surgery, comprising: programming a position and orientation for an effector based on the movement of a haptic device, reference and modelled effector coordinates, and an estimated position of the fulcrum; obtaining articular speeds and positions in order for the robot unit to locate the next effector position and orientation; moving the effector; measuring forces and moments exerted by the effector and by a minimally invasive instrument when this movement is performed; determining the contribution to said measurement resulting from the interaction with the fulcrum point and with the internal tissue; estimating the external distance at which the fulcrum point is located relative to the modelled effector; estimating the stiffness of the tissue in contact with the instrument and calculating a simulated reaction force; sending same to the haptic device and in turn to the hand of the surgeon.

IPC Classes  ?

• A61B 34/37 - Leader-follower robots
• B25J 13/02 - Hand grip control means

Goods & Services

Teaching; Training; Entertainment services; Sporting and cultural activities. Science and technology services; Scientific services and design relating thereto; Technological services and design relating thereto; Scientific research; Industrial analysis services; Industrial research; Software design and development; Design and development of computer hardware. Legal services; Security services for the protection of property and individuals.

Abstract

The invention relates to a method for obtaining data that can be used to predict, or establish a prognosis for the risk of an individual developing metabolic syndrome or a disease associated with metabolic syndrome, preferably diabetes, and to a kit and the use of same.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method for obtaining IFNAR recombinant protein and to the use thereof in the production of a drug for prevention, control, relief and/or treatment of a disease.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• A61P 31/12 - Antivirals

Abstract

The present invention relates to a combination comprising galanin and [Leu31,Pro34]NPY, and to the use of said combination for a disease of the nervous system, particularly depression. The invention also relates to a screening method for the identification of galanin receptor 2 (GALR2) agonists and/or neuropeptide Y Y1 receptor (NPYY1R) agonists.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/24 - Antidepressants
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Digital witness: The invention relates to methods and devices for the secure management of electronic evidence with binding credentials. More specifically, the invention relates to a device for the secure management of electronic evidence with binding credentials (digital witness), to which device the identity of the user or object obtaining, generating or receiving evidence is delegated in a binding and indissoluble manner using binding credentials, said device being characterised in that it comprises a manager for managing operations between the user and the object, accepted cryptographic mechanisms inside a secure element, access-controlled secure storage means protected in a secure element (core of trust), a manager for managing electronic evidence for objects, and, optionally, a contractual manager. The invention also relates to methods using said digital witnesses and comprising obtaining, stamping, storing, delegating and, where appropriate, deleting electronic evidence.

IPC Classes  ?

• G06F 21/00 - Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity

Abstract

The invention relates to a method for the identification, isolation and/or selection of one or more cells, cell cultures or tissues that can be used to increase, restore or substitute, partially or fully, the functional activity of different portions of urethral tissue. The invention also relates to the use of said cell(s), cell culture(s) or tissue(s), to a kit or device, to the pharmaceutical composition, and uses of same.

IPC Classes  ?

• G01N 33/532 - Production of labelled immunochemicals

Abstract

The invention relates to a mechanism for moving partition walls or panels linearly and for rotating same through 360º, characterised in that it comprises: an inverted-Y-shaped part (6), two conical wheels (8) which can be inserted into shafts provided on the part (6) and which, once inserted, are held in place but can rotate, and a ring part (7) that bears on the wheels (8) and that has a surface machined such that the thickness thereof increases and decreases every 90º, so that the ring part rises and falls as it rotates on the conical wheels, its rotational movement being converted into a vertical linear movement. The invention also relates to enclosure systems using the aforementioned mechanism and comprising lower and upper guide profiles and two mechanisms per panel or wall which are housed in lower and upper casings that slide along the length of the guide profiles.

IPC Classes  ?

• E05D 15/06 - Suspension arrangements for wings for wings sliding horizontally more or less in their own plane
• E05D 15/30 - Suspension arrangements for wings supported on arms movable in horizontal plane with pivoted arms and sliding guides

Abstract

The invention relates to the dehydration of sorbitol to isosorbide in the absence of a solvent by means of heterogeneous catalysis using sulphonic resins as catalysts. The present invention, which solves problems associated with homogeneous catalysis as well as requirements of other sulphonic resins and other catalysts, relates to the use of different styrene-divinylbenzene resins, the polymer structure of which consists of macroporous polystyrene cross-linked with divinylbenzene, as solid acid catalysts in a heterogeneous catalytic process for dehydrating sorbitol to isosorbide. The invention also relates to heterogeneous catalytic processes for dehydrating sorbitol to isosorbide in the absence of a solvent, either at atmospheric pressure or in vacuum conditions, which comprise: adding the resins used as catalysts in a sorbitol:catalyst mass ratio between 10:1 and 10:2; reacting at 140-180° C for 1.5-12 hours; subsequently diluting the melt volume; and separating the catalyst and sugars by microfiltration.

IPC Classes  ?

• C07D 493/04 - Ortho-condensed systems
• C07C 29/50 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups with molecular oxygen only
• B01J 31/10 - Ion-exchange resins sulfonated
• C07H 1/00 - Processes for the preparation of sugar derivatives

Abstract

The invention relates to a method for producing electrodes and/or microelectrodes for electrochemical and analytical applications, from the selective deposition of superporous nanostructured carbonaceous materials, directly by means of electrospraying a suspension of the carbonaceous material with a binder on the current collector. This electrospraying technique allows said carbonaceous materials to be selectively deposited on different types of current collectors, which are used directly as electrodes or microelectrodes, where said electrodes and microelectrodes can be used as electrochemical sensors or in supercapacitors, inter alia.

IPC Classes  ?

• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B05B 5/16 - Arrangements for supplying liquids or other fluent material

Abstract

The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumors using the expression signature of particular miRNAs. Specifically, the invention relates to a method for determining the risk of recurrence of breast cancer which comprises measuring the expression levels of at least one miRNA selected from the group consisting of miR-149-5p (SEQ ID NO: 1), miR-10a-5p, (SEQ ID NO: 2), miR-20b-5p, (SEQ ID NO: 3), miR-30a-3p (SEQ ID NO: 4), and miR-342-5p, (SEQ ID NO: 5) in a sample of the tumor, wherein a change in the expression level of at least one miRNA in the tumor with respect to the expression level in a control sample is indicative of a high risk of recurrence of the tumor. The invention also relates to tools and kits for carrying out the method of the invention.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Disclosed are a system and method for optimising word widths of digital circuits by means of bit-true simulations. The system comprises a model of the target circuit (5) with limiter circuits (7) that modify the value of the signals of which the word width is to be optimised, reducing the execution times of optimisation processes, without needing to reconfigure the PLD or emulate word widths by means of software instructions. Each limiter circuit (7) generates an output, limiting, at the logical level, the precision and/or effective range of the value of a piece of input data (NUM¡) according to a received instruction for controlling precision and/or effective range (10¡). The model of the target circuit (5) can be implemented in a hardware circuit of a PLD (2) or by means of software in a processor (8). Each limiter circuit (7) is normally located at the input and/or output of an arithmetic-logic operator (9) or arithmetic-logic unit (19).

IPC Classes  ?

• G06F 7/00 - Methods or arrangements for processing data by operating upon the order or content of the data handled
• G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions

Goods & Services

Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Magnetic data carriers, recording discs; Compact discs, DVDs and other digital recording media; Memory sticks; Data processing equipment, computers; Computer software; Computer software downloadable from global computer information networks; Downloadable publications; Electronic dictionaries; Mechanisms for coin-operated apparatus; cash registers, calculating machines; Fire-extinguishing apparatus. Paper and cardboard; Forms, printed; Flyers; Catalogues; Books; Magazines (periodical); Printed publications; Dictionaries; Graphic reproductions; Printed matter; Bookbinding material; Geographical maps; Posters; Rub down transfers; Cards; Photographs; Stationery; Adhesives for stationery or household purposes; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Bags [envelopes, pouches] of paper or plastics, for packaging; Printers' type; Printing blocks. Management and compilation of computerised databases; Computerised file management; Wholesale services in relation to computer software; Layout services for advertising purposes; Commercial or industrial management assistance; Business administration; Office functions; Advertising and marketing services; Sponsorship search; Import-export; Services of commercial representations; Retailing, wholesaling and sale via global computer networks of magnetic data carriers, recording discs, compact discs, DVDs and other digital recording media, memory sticks, data processing equipment, computers, computer software, computer software downloadable from global computer information networks, downloadable publications, electronic dictionaries; Retailing, wholesaling and sale via global computer networks of paper and cardboard, dictionaries, graphic reproductions, printed forms, information leaflets (flyers), catalogues, books, magazines (periodical publications), printed publications, printed matter, bookbinding material, geographical maps, posters, transfers, cards, photographs, stationery; Retailing, wholesaling and sale via global computer networks of office requisites, instructional and teaching materials, plastic materials for packaging, bags (envelopes, pouches) of paper or plastic for packaging, printers' type, printing blocks; Retailing, wholesaling and sale via global computer networks of promotional articles, namely key rings, badges, pins, leatherware, jewellery and horological instruments; Retailing, wholesaling and sale via global computer networks of decorative items of glass, porcelain, earthenware and terra cotta, ready-made clothing and headgear; Demonstration of goods for advertising purposes; Marketing studies and business appraisals; Opinion polling; Organisation of trade fairs and exhibitions for commercial or advertising purposes. Telecommunication services; Access to content, websites and portals; Providing access to databases; Consultancy on telecommunications; Communication by electronic means; Radio and television broadcasting; Distribution of data or audio visual images via a global computer network or the internet; Audiovisual communication services; Broadcasting of radio and television programmes, including via a cable network and via the internet; Sending of telegrams; Providing access to a global computer network for the transfer and dissemination of information; Providing access to weblogs; Providing on-line forums for transmission of messages among computer users; Providing on-line chat rooms for social networking; Audio teleconferencing; Electronic transmission of computer programs via the internet. Tuition; Providing of training; Entertainment; Sporting and cultural activities; Providing of information relating to education, entertainment and sport; Arranging of trade fairs and exhibitions for cultural or educational purposes; Publication of books and texts, other than publicity texts; Publishing of books; Providing on-line electronic publications, not downloadable; Providing publications from a global computer network or the internet which may be browsed; On-line library services, namely, providing electronic library services which feature newspapers, magazines, photographs and pictures via an on-line computer network; Arranging and conducting of competitions (education or entertainment), organisation of awards; Arranging of colloquiums, conferences and congresses; Providing museum facilities (presentation, exhibitions); Production of shows and live theatre productions. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software; Maintenance and updating of computer software; Application service provider services; Advice and consultancy in the field of computers and computer software.

Abstract

The invention relates to a computer vision system and method for the detection of anomalous objects (pedestrians or animals) on roads or motorways. The invention relates to a system comprising a digital camera (1) which supplies images to a CPU (2) that uses a moving-object detector (3) which transmits information relating to the objects present in each frame to an object-tracking module (4), said module identifying the trajectories and speeds of the objects present in each frame and supplying said information to an anomaly detector (5) which categorises the objects as normal or anomalous and which, alternatively, transmits the information relating to anomalous objects to a communications module (6) that can be used to obtain information about the objects. The invention also relates to a method for the detection of said anomalous objects, comprising the steps of capturing images, detecting objects, tracking objects and detecting anomalous objects.

IPC Classes  ?

• G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06T 7/00 - Image analysis
• H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
• G08B 21/02 - Alarms for ensuring the safety of persons

Abstract

Laser nanostructuring and microstructuring of silicon using a laser-induced plasma for the processing of the processing laser beam. The method according to the invention is characterised in that it comprises a step of ablation wherein a first, ablation pulsed laser beam is directed, with a fluence in the range of 10 - 100 J·cm-2, onto the surface of a metal sample generating a laser-induced plasma, and a processing step wherein a second, processing pulsed laser beam, is directed, with a fluence of 0,3 Jcm-2, delayed by between 0.1 and 1 microseconds in relation to the ablation laser beam, onto a silicon surface close to the laser-induced plaza such that said second laser beam passes through said plasma perpendicularly to the plasma expansion axis.

IPC Classes  ?

• B23K 26/00 - Working by laser beam, e.g. welding, cutting or boring
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
• B82Y 40/00 - Manufacture or treatment of nanostructures

Goods & Services

Bags and articles for packaging, wrapping and storage of paper, cardboard or plastics; Filtering materials of paper; Printed matter; Decoration and art materials and media; Paper and cardboard; Works of art and figurines of paper and cardboard, and architects' models; Stationery and educational supplies; Disposable paper products; Money holders. Headgear; Footwear; Clothing. Education, entertainment and sports; Publishing and reporting; Translation and interpretation. Testing, authentication and quality control; Science and technology services; Design services; IT services.

Abstract

The invention relates to methods for producing absorbent materials based on clay minerals, preferably smectites, particularly preferably dioctahedral and/or trioctahedral smectites, even more preferably montmorillonite and/or saponite, and comprising the following steps: (1) dispersing and delaminating the starting material; (2) impregnating the monolayers of the starting material with a reactive solution comprising metal oxides added in a quantity equal to the equivalents corresponding to the capacity for cation exchange calculated for said starting material; (3) decanting and washing; (4) drying and calcinating; and (5) milling. The invention also relates to the produced absorbent materials, the intermediate materials of said methods, and the applications of the starting, intermediate or final materials in purifying or treating water.

IPC Classes  ?

• B01J 20/12 - Naturally occurring clays or bleaching earth
• C02F 1/28 - Treatment of water, waste water, or sewage by sorption

Abstract

The invention relates to methods used in a computer for selecting absorbent materials for the treatment or purification of contaminated water, which comprise the steps of (1) selecting the adsorption system, (2) identifying the problem, (3) modelling and processing data, and (4) evaluating and deciding, and which provide an indication of efficiency, in particular of the most efficient absorbent material, and, if appropriate, of the necessary quantity or concentration of said material, and, if appropriate, of the cost-efficiency ratio. The invention also relates to computer systems, computer programs, carrier means and transmittable signals. The invention further relates to the use of said methods, computer systems, computer programs, carrier means or transmittable signals in the treatment or purification of contaminated water.

IPC Classes  ?

• C02F 3/00 - Biological treatment of water, waste water, or sewage

Abstract

The invention relates to a first method comprising the use of the path metrics on the right-hand edge of the sub-blocks as initialisation metrics for the following sub-block of the following iteration, and the use of the path states of the left-hand edge of the sub-blocks to create the last movement backwards from a reliable state of the previous SOVA decoder. The invention also relates to a second method comprising the storage of the LLR metrics in an input memory bank, the calculation of a posteriori metrics via the decoder(s), the calculation of the extrinsic information via one or more extrinsic calculation units, and the comparison of the a posteriori LLR measurements throughout different iterations. The invention further relates to systems that carry out said methods.

IPC Classes  ?

• H03M 13/29 - Coding, decoding or code conversion, for error detection or error correctionCoding theory basic assumptionsCoding boundsError probability evaluation methodsChannel modelsSimulation or testing of codes combining two or more codes or code structures, e.g. product codes, generalised product codes, concatenated codes, inner and outer codes

Abstract

The invention relates to bio-active glasses and the uses thereof, said glasses comprising boron oxide, and having a substitution of bonds B-0 in the structure due to the formation of bonds B-N caused by nitriding. The glasses preferably also comprise other oxides, such as those included, and preferably ordered according to their molar percentage and from largest to smallest, in the sequence SiO2 > CaO > Na2O > K2O > B2O3 > P2O5. The invention also relates to methods for producing nitrided bio-active glasses, comprising: the mixing of glass powders containing boron oxide and additional oxides where appropriate; and the nitriding of said mixture. The invention further relates to nitrided scaffolds comprising said bio-active glasses, to preparation methods thereof, and to uses thereof.

IPC Classes  ?

• C03C 3/087 - Glass compositions containing silica with 40% to 90% silica by weight containing aluminium oxide or an iron compound containing an oxide of a divalent metal containing calcium oxide, e.g. common sheet or container glass
• A61L 27/10 - Ceramics or glasses
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

The invention relates to a recombinant protein and uses thereof in the diagnosis and treatment of multiple sclerosis. The invention also relates to the recombinant protein IFNAR2.3, antibodies, compositions comprising same, and uses thereof. Among the uses thereof, the invention especially relates to a method for the diagnosis of multiple sclerosis, and to the diagnosis kit. The invention further relates to the use of the protein IFNAR2.3 in the preparation of a medicament for the treatment of multiple sclerosis.

IPC Classes  ?

• C07K 14/565 - IFN-beta
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 14/715 - ReceptorsCell surface antigensCell surface determinants for cytokinesReceptorsCell surface antigensCell surface determinants for lymphokinesReceptorsCell surface antigensCell surface determinants for interferons
• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The method for the production of said particles and materials comprises electrospraying or electrospinning a mixture of at least one type of carbonaceous precursor and at least one type of chemical agent, preferably a precursor of phosphorous species, said carbonaceous precursor being functionalised with phosphorus homogeneously by means of dissolution in an appropriate solvent in suitable proportions and conditions, said method comprising between 1 and 3 additional steps compared to those of electrospraying or electrospinning which, in turn, encompass up to 6 different processes and which are carried out, according to the individual case, in either a single inert or oxidising atmosphere, or in up to three different atmospheres. The invention also relates to the carbonaceous particles and materials obtained by means of any of the variants of the method, to applications of said particles, and to said carbonaceous materials.

IPC Classes  ?

• C01B 31/02 - Preparation of carbon; Purification
• C01B 31/12 - Preparation by using non-gaseous activating agents
• D01F 9/17 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from products of vegetable origin or derivatives thereof, e.g. from cellulose acetat from lignin
• D01D 5/14 - Stretch-spinning methods with flowing liquid stretching media

Abstract

Devices for adding floating-point numbers, devices for multiplying floating-point numbers, devices for performing fused multiply-add floating-point operations, devices for performing operations with fixed-point numbers and the converters related to same. A pre-processed fixed-point format is a fixed-point format in which the LSD of all of the numbers represented exactly in said format is equal to B/2 (i.e. 1 for binary base), and the remainder are rounded to one of these numbers. A pre-processed floating-point format is a floating-point format in which the mantissa is a pre-processed fixed-point number.

IPC Classes  ?

• G06F 7/38 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation

Abstract

The invention relates to the field of oncology and cancer treatment. The invention relates to methods for predicting the risk of recurrence of breast tumours using the expression signature of particular miRNAs. In particular, the invention relates to a method for determining the risk of breast cancer recurrence, comprising the measuring of the levels of expression of at least one miRNA selected from the group containing miR-49-5p (SEQ ID NO: 1), mi R-10a-5p, (SEQ ID NO: 2), mi R-20b-5p, (SEQ ID NO: 3), mi R-30a-3p (SEQ ID NO: 4), and miR-342-5p, (SEQ ID NO: 5) in a sample of the tumour, wherein a change in the level of expression of at least one miRNA in the tumour, in relation to the level of expression in a control sample, is indicative of an increased risk of recurrence of the tumour. The invention also relates to tools and kits for carrying out the method according to the invention.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Fluid medicament infusion device that has a pressurised medicament reservoir, a catheter for administering the drug to the patient and a valve arranged between both, wherein the valve has an intermediate chamber (19) that, depending on the position of an obturator element (9), is alternately in communication either with the reservoir (1) in order for the latter to be filled with medicament, or, alternatively, with the catheter (8) for the administration of medicament. A dispensing plunger (11) that has an extended position in which the end thereof is at least in part inserted in the intermediate chamber (19) is responsible for propelling the fluid medicament towards the catheter. The precision of current devices is improved, since it is possible, with a high level of precision, to control the volume of medicament administered to the patient with a high degree of precision. The design of the valve affords greater safety.

IPC Classes  ?

• A61M 5/168 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters
• A61M 39/24 - Check- or non-return valves

Abstract

The invention describes a device (1) for drilling and fixing the osteochondral graft (100) in the surgical technique of traction mosaicplasty, the device (1) comprising: a first body (2) with a first cylindrical through-hole (3) for receiving a graft (100); and a second body (4), contiguous with the first body (2), which has a second cylindrical through-hole (5) for receiving a drill bit (25) or a rod (27), in which the first hole (3) has a diameter that is larger than the second hole (5), and in which the first hole (3) and the second hole (5) are mutually coaxial.

IPC Classes  ?

• A61F 2/46 - Special tools for implanting artificial joints

Abstract

The present invention relates to methods for bioencapsulation of the probiotic Shewanella putrefaciens Pdp11 in living food; to the use of said probiotic as a modulator of the total content of proteins and fats, in particular of docosahexaenoic acid (DHA), in a living food, in particular in brine shrimp; a probiotic food which includes Shewanella putrefaciens Pdp11 bioencapsulated in a living food, in particular Shewanella putrefaciens Pdp11 bioencapsulated using the bioencapsulation methods that are also the subject of the present invention; and uses of said probiotic food in the modulation of various biochemical parameters and biological processes, such as the DHA / EPA (docosahexaenoic acid / eicosapentaenoic acid) ratio, the stimulation of metamorphosis in larvae, or the composition of the intestinal microbiota in larvae; said uses including the administration of probiotic food in pulses of various lengths applied at various times in the growth of the fish.

IPC Classes  ?

• A23K 1/18 - specially adapted for particular animals
• A61K 39/02 - Bacterial antigens
• A01K 61/00 - Culture of aquatic animals

Abstract

Downconverter with polarization diversity for coherent optical receiver with polarization division multiplexing, capable of being monolithically integrated. In said downconverter, the polarization diversity network of the prior art is replaced by a phase-assisted polarization diversity and coupling network that reduces or even eliminates the need to use polarization separators and rotators with high extinction ratios. This makes it possible to achieve polarization diversity functionality with a high level of precision, based on individual components with lower performance levels (in terms of the capacity thereof to manipulate polarization), which facilitates the monolithic integration of the complete receiver into a single wafer. A further subject of the invention is a coherent optical receiver that comprises said downconverter with polarization diversity for polarization division multiplexed optical signals.

IPC Classes  ?

• H04B 10/64 - Heterodyne

Abstract

The invention relates to an electromagnetic chipless identification label comprising at least one multi-conductive structure printed on a dielectric substrate for identification compatible with unidimensional bar codes. The encoding of said label comprises defining the resonance frequency of multi-conductive structures which will replace bar code digits. The production of said label comprises defining the widths of the conductors of the multi-conductive structure and the separating distances between same in accordance with the corresponding bar code standard (310, 311); and selecting and replacing the corresponding digits in the bar code by printing multi-conductive structures (320a, 320b, 320c). The reading of said label involves the use of a transmission line arranged close to the label, said line moving longitudinally along the label in order to carry out a reading by coupling the electromagnetic field.

IPC Classes  ?

• G06K 19/067 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards