Abstract

Additive ultrasonic manufacturing system for additive manufacturing applying simultaneously pressure and temperature, comprising: a robot or a robotic arm; a coupling unit, attached to the robot or robotic arm and comprising a sliding channel; a manufacturing head connected to the coupling unit and comprising at least one ultrasonic welder, and a mass control unit, configured to add and remove masses from the head automatically; and an additive ultrasonic manufacturing method comprising the steps of determining a first amplitude and a first power for the ultrasonic welder; determining a first mass for adding to the manufacturing head; determining a first velocity for the manufacturing head; activating the ultrasonic welder and the robot or robotic arm; measuring a temperature and a pressure applied on the manufacturing surface; modifying the first amplitude, the first power and the first mass determined to achieve a welding temperature and pressure for the material to be welded.

IPC Classes  ?

• B29C 65/08 - Joining of preformed parts; Apparatus therefor by heating, with or without pressure using ultrasonic vibrations
• B29C 64/295 - Heating elements
• B29C 65/00 - Joining of preformed parts; Apparatus therefor
• B23K 20/10 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating making use of vibrations, e.g. ultrasonic welding
• B23K 20/22 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating taking account of the properties of the materials to be welded
• B29C 65/82 - Testing the joint
• B23K 20/233 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating taking account of the properties of the materials to be welded without ferrous layer
• B33Y 10/00 - Processes of additive manufacturing
• B29C 65/16 - Laser beam
• B29C 65/30 - Electrical means
• B29C 65/32 - Induction
• B29C 65/78 - Means for handling the parts to be joined, e.g. for making containers or hollow articles
• B23K 103/00 - Materials to be soldered, welded or cut
• B23K 103/16 - Composite materials
• B23K 103/08 - Non-ferrous metals or alloys
• B23K 103/02 - Iron or ferrous alloys

Abstract

The present invention is directed to new compounds based on polyelectrophilic metalated heterocycles derived from 2-(pyridin-2-yl)imidazo[1,2-a]pyridine, to their obtaining procedure, as well as to their use as chemotherapeutic agents, in particular against tumours sensitive or resistant to other chemotherapeutic agents, such as cisplatin.

IPC Classes  ?

• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic System
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
• A61K 33/243 - Platinum; Compounds thereof
• A61P 35/00 - Antineoplastic agents
• C07D 471/04 - Ortho-condensed systems
• C07D 471/16 - Peri-condensed systems

Abstract

The present invention relates to a cell co-culture device intended for use in cell bioenergetic analysis equipment. The device comprises a cell culture base plate (1) and a co-culture plate (8) placed above the base plate (1). The base plate (1) comprises a base (2), walls (3), an upper sector (4) and first wells (5) with a bottom (2) that holds a cell of a first type. The co-culture plate (8) comprises a second upper sector (9) and second wells (10) partially housed in the first wells (10) and provided with a lid (13) that holds a cell of a second type. Thus, the influence of the presence of cells of a second type on the cells of a first type, which are the cells to be analysed, can be analysed by using the same bioenergetic equipment as is currently used.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

Compounds derived from ursodeoxycholic acid of formula (I) and to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

IPC Classes  ?

• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Abstract

A signal processing arrangement is described for signal processing in a bilateral hearing implant system. A channel compression module develops a inhibition-adjusted band pass signal for each band pass signal using a channel-specific dynamic inhibition adjustment based on a channel-normalized medial olivocochlear reflex model that reflects bandwidth energy for a corresponding contralateral band pass signal and bandwidth energy for a selected reference contralateral band pass signal.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/02 - Electrotherapy; Circuits therefor - Details
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The present invention relates to peptides comprising the amino acid sequence having a sequence identity of at least 70% with SEQ ID NO: 1, provided that said peptides do not have the amino acid sequence SEQ ID NO: 2 or SEQ ID NO: 3, and that the cysteine at position 6 of SEQ ID NO: 1 remains unchanged. The invention also relates to a pharmaceutical composition thereof and to its uses in the treatment of tumours, in particular, in the treatment of cancer and metastases.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids

Goods & Services

Education and instruction services; Training; Distance learning services provided online; Publishing of medical publications; Providing online electronic publications, not downloadable; Publication of text books; Providing on-line publications; Reference libraries of literature and documentary records; Publication of educational and training guides; Publication of newspapers, periodicals, catalogs and brochures; Online publication of electronic books and journals; Arranging of lectures; Training in the field of medicine; Organization of seminars and conventions in the field of medicine; Publishing of journals, books and handbooks in the field of medicine; Providing continuing medical education courses; Education services relating to medicine; Publication of medical texts; Developing international student exchange programs; Certification in relation to educational awards; Postgraduate training courses.

Abstract

in vitro in vitro in vitro method of diagnosing a neuronal ceroid lipofuscinosis in a subject, which are both based on the finding that an increased level of globotriaosylceramide (Gb3) is a marker for Batten Disease.

IPC Classes  ?

• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention refers to an in vitro method for the prognosis of patients suffering from sepsis, preferably COVID-19 patients. In a preferred embodiment, a bad prognosis means that the patient has an increased risk of developing Acute respiratory distress syndrome (ARDS).

IPC Classes  ?

• G01N 33/564 - Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease

Abstract

The method comprises A method includes steps for creating at least two replicas of an input pulse to be characterised, varying the relative amplitude of the two replicas within a range, creating a nonlinear signal at each case of said amplitude variation, measuring the spectra of the nonlinear signals and recovering the spectral amplitude and phase of the input pulse with a proper algorithm. The system includes a replicator for creating at least two replicas of the input pulse and varying their relative amplitude within a range of relative amplitudes, a nonlinear medium, which obtains a nonlinear signal for each relative amplitude, and an analyzer, associated to the nonlinear signal for measuring and characterising spectrally each nonlinear signal.

IPC Classes  ?

• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• G01J 3/45 - Interferometric spectrometry

Goods & Services

Education (teaching); teaching (training); further education; teaching in the field of nursing; education services relating to tuition in nursing; vocational training; vocational education relating to nursing; provision of vocational training courses; coaching (training); educational services in the nature of coaching; providing continuing nursing education courses.

Abstract

The invention relates to a device and method for the simultaneous lyophilisation of a plurality of biological samples ensuring the traceability of said samples intended to be housed within coded containers (1); the device comprises a diffuser block (2) comprising a plurality of openings which define receptacles (21) to house the coded containers (1), wherein the diffuser block (2) further comprises a perimeter cavity (24) configured so that the alloy surrounding each receptacle (21) is similar in all the coded containers (1), enabling high thermal homogeneity, and the receptacles (21) have through openings defining an open bottom (23) to scan the coded containers (1). Likewise, the device further comprises a transfer lid (3) to ensure the position of each container (1) when it is transferred to the diffuser block (1) and back to the starting box (4).

IPC Classes  ?

• F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
• F26B 25/00 - DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM - Details of general application not covered by group or

Abstract

The present invention relates to a rehabilitation device that enables patients undergoing the rehabilitation of an injured lower limb to assess whether the load applied when supported by their lower limb while walking is within the range stipulated by the physiotherapist and/or physician. Specifically, the load monitoring device attachable to crutches and/or walking sticks comprises: a bar with a cylindrical upper end configured to be attached to the support bar of a crutch and/or walking stick, a tightening means installed at the upper end of the bar in order to attach the bar to the support bar of a crutch and/or walking stick, and a ferrule made of an elastic material attached to the lower end of the bar, and a pressure transducer located within the ferrule, in such a way that the transducer can measure the pressure exerted on the bar in the direction of the pressure transducer.

IPC Classes  ?

• A61H 3/02 - Crutches
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• G08B 21/00 - Alarms responsive to a single specified undesired or abnormal condition and not otherwise provided for

Abstract

The method comprises steps of: creating at least two replicas (21) of an input pulse (1) to be characterised, varying the relative amplitude of the two replicas (21) within a range, creating a nonlinear signal (31) for each case of said amplitude variation, measuring the spectra of the nonlinear signals (31), and recovering the spectral amplitude and phase of the input pulse (1) by means of a suitable algorithm. The system comprises means (2) for creating at least two replicas (21) of the input pulse (1) and varying their relative amplitude within a range of relative amplitudes, a nonlinear medium (3), which obtains a nonlinear signal (31) for each relative amplitude, and analysing means (4) for measuring and characterising spectrally each nonlinear signal (31).

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range

Abstract

The present invention relates to a transgenic plant, preferably of the Brassica spp. genus, comprising in its genome a fungal sequence, preferably belonging to the fungus Trichoderma harzianum, capable of establishing symbiosis with mycorrhizal fungi. Additionally, the transgenic plants of the invention have an increased biomass and higher resistance to abiotic stress. The present invention also provides methods for increasing the resistance to abiotic stress of plants of the Brassica spp. genus, as well as methods for obtaining said transgenic plants with the capacity to establish mycorrhization processes and resistance to abiotic stress and methods for producing foods, feeds or industrial products using the transgenic plant.

IPC Classes  ?

• A01H 17/00 - Symbiotic or parasitic combinations including one or more new plants, e.g. mycorrhiza
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

Brassica spp.Trichoderma harzianumBrassica spp.Brassica spp. genus, as well as methods for obtaining said transgenic plants with the capacity to establish mycorrhization processes and resistance to abiotic stress and methods for producing foods, feeds or industrial products using the transgenic plant.

IPC Classes  ?

• A01H 17/00 - Symbiotic or parasitic combinations including one or more new plants, e.g. mycorrhiza
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells

Abstract

The present invention relates to compounds derived from ursodeoxycholic acid of formula (I), to methods for obtaining same, as well as the use thereof in the treatment of polycystic diseases, particularly autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease, or autosomal recessive polycystic kidney disease.

IPC Classes  ?

• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

Abstract

The invention relates to a device and method for the simultaneous lyophilisation of a plurality of biological samples ensuring the traceability of said samples intended to be housed within coded containers (1); the device comprises a diffuser block (2) comprising a plurality of openings which define receptacles (21) to house the coded containers (1), wherein the diffuser block (2) further comprises a perimeter cavity (24) configured so that the alloy surrounding each receptacle (21) is similar in all the coded containers (1), enabling high thermal homogeneity, and the receptacles (21) have through openings defining an open bottom (23) to scan the coded containers (1). Likewise, the device further comprises a transfer lid (3) to ensure the position of each container (1) when it is transferred to the diffuser block (1) and back to the starting box (4).

IPC Classes  ?

• F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
• F26B 25/00 - DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM - Details of general application not covered by group or

Abstract

An antibody or fragment thereof, against presenilin, and more specifically against the luminal loop 1 of presenilin, for use in the treatment of cancer, by way of administrating a therapeutically effective quantity of the antibody or a fragment thereof, or a pharmaceutical composition comprising thereof, to a subject who suffers from cancer.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 16/38 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

A signal processing arrangement is described for signal processing in a bilateral hearing implant system. A channel compression module develops a inhibition-adjusted band pass signal for each band pass signal using a channel-specific dynamic inhibition adjustment based on a channel-normalized medial olivocochlear reflex model that reflects bandwidth energy for a corresponding contralateral band pass signal and bandwidth energy for a selected reference contralateral band pass signal.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/02 - Electrotherapy; Circuits therefor - Details
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

Abstract

The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present application relates to a method and system for characterization and compression of ultrashort pulses. It is described a flexible self-calibrating dispersion-scan technique and respective system to characterize and compress ultrashort laser pulses over a broad range of pulse parameters, where previous knowledge of the amount of dispersion introduced for each position or step of the compressor is not required. The self-calibrating d-scan operation is based on the numerical retrieval of the spectral phase of the pulses using an optimization algorithm, where the spectral phase is treated as a multi-parameter unknown variable, and where the unknown dispersion of the dispersion scanning system is described by a theoretical model of its functional dependence on the compressor position.

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• G02F 1/35 - Non-linear optics

Abstract

An apparatus and a method for in-line measurement of laser pulses with time-dependent polarization are described, which make possible to carry out in-line measurement of laser pulses whose polarization depends on time. For this, one or more polarization projections are selected: the spectrometer detects the projection on the extraordinary propagation axis of a birefringent system to measure the spectrum in that component, also the projection on the ordinary propagation axis, to measure the spectrum in that component, and finally a projection in an intermediate direction that allows to measure the interference spectrum between the two components. The method allows extracting the temporal evolution of the pulse and its polarization state as a function of time, spectral amplitudes and phases of the various polarization projections of the beam.

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range

Abstract

The present invention relates to compounds of formula (I) derived from ursodeoxycholic acid, to processes for preparing them and to their use for the treatment of polycystic diseases, in particular autosomal dominant polycystic liver disease, autosomal dominant polycystic kidney disease or autosomal recessive polycystic kidney disease.

IPC Classes  ?

• C07J 17/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta[a]hydrophenanthrene skeleton
• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

The present invention relates to a specific antibody, or fragment thereof, against presenilin, and more specifically against luminal loop 1 of presenilin, for use in the prevention and/or treatment of cancer, by means of the administration of a therapeutically effective quantity of said antibody or a fragment thereof, or a pharmaceutical composition comprising same, to a cancer patient.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

The present application relates to a method and system for characterization and compression of ultrashort pulses. It is described a flexible self-calibrating dispersion-scan technique and respective system to characterize and compress ultrashort laser pulses over a broad range of pulse parameters, where previous knowledge of the amount of dispersion introduced for each position or step of the compressor is not required. The self-calibrating d-scan operation is based on the numerical retrieval of the spectral phase of the pulses using an optimization algorithm, where the spectral phase is treated as a multi-parameter unknown variable, and where the unknown dispersion of the dispersion scanning system is described by a theoretical model of its functional dependence on the compressor position. The apparatus for pulse characterization may comprise in this sequence a telescope (52), a wedge (53) for providing a controllable amount of dispersion, a non-linear medium for frequency doubling (55), a polarizer (56), a lens (57) and an imaging spectrometer (58).

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range

Abstract

A signal processing arrangement is described for signal processing in a bilateral hearing implant system. A channel compression module develops a inhibition-adjusted band pass signal for each band pass signal using a channel-specific dynamic inhibition adjustment based on a channel-normalized medial olivocochlear reflex model that reflects bandwidth energy for a corresponding contralateral band pass signal and bandwidth energy for a selected reference contralateral band pass signal.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present invention relates to a cork cleaning system for eliminating haloanisoles and halophenols, which allows vacuum pressures of the order of 10-6 mbar to be achieved. According to the invention, the system comprises a set of metal tubes inside which the cork is arranged, said metal tubes being perforated and surrounded by conduction heating means, such that the heat is transferred to the perforated metal tubes. In addition, the system comprises high vacuum pumps distributed uniformly throughout the perforated metal tubes, thereby facilitating the transmission of a high vacuum pressure to all of the cork arranged inside the perforated metal tubes.

IPC Classes  ?

• B27K 7/00 - Chemical or physical treatment of cork
• B27K 5/00 - Staining or dyeing wood; Bleaching wood; Treating of wood not provided for in groups  or 
• B01J 3/04 - Pressure vessels, e.g. autoclaves
• B67B 1/03 - Pretreatment of stoppers, e.g. cleaning, steaming, heating, impregnating or coating; Applying resilient rings to stoppers

Abstract

An apparatus and method are described for the online measurement of laser pulses with time-dependent polarisation, which apparatus and method allow laser pulses with time-dependent polarisation to be measured online. For that purpose, one or more polarisation projections are selected: the spectrometer detects the projection of a birefringent system along an extraordinary propagation axis in order to measure the spectrum in this component, the projection along the ordinary propagation axis in order to measure the spectrum in this component, and finally a projection in an intermediate direction that makes it possible to measure the interference spectrum between these two components. The method makes it possible to extract the evolution in time of the pulse and its state of polarisation as a function of time, the amplitudes and spectral phases of the various beam polarisation projections.

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains

Abstract

The invention relates to a computer-implemented method for classifying events present in a sample, wherein each event is characterized by a multidimensional set of parameters obtained by means of hardware and/or software, wherein the values of the parameters associated with each event define the position coordinates of said event in a multidimensional space. Said method comprises the following stages: a) clustering the events in groups, b) checking if within each formed group there is a connection between events exceeding a maximum distance threshold, c) calculating the affinity between each pair of previously generated sample groups, d) comparing each sample group with at least one reference group stored in at least one database, e) classifying the sample groups based on the comparisons with the reference groups.

IPC Classes  ?

• G06K 9/62 - Methods or arrangements for recognition using electronic means
• G06F 17/30 - Information retrieval; Database structures therefor
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints

Goods & Services

Teaching Spanish as a foreign language, teacher training, teacher training, organization of pedagogical tests and exhibitions for cultural or educational purposes; editing of educational videos and texts.

Abstract

The present invention relates to a method for obtaining the DNA sequence pattern determining the nucleosome positioning characteristic of a particular eukaryotic species. It further relates to a method for tailoring coding and/or non-coding DNA sequences to obtain the nucleosome positioning characteristic of a given eukaryotic species. In addition, it also relates to a method of codon optimization based on the modification of nucleosome positioning of a coding and/or non-coding DNA sequence for improving its expression in a host eukaryotic species.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to methods to evaluate in one single assay the biocompatibility of materials based on the simultaneous determination of the phagocytosis, cell activation and cell death produced by said materials, preferably, in peripheral blood or other human cells and proximal fluids. The invention also relates to a kit to perform the method of the invention.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Goods & Services

Teaching Spanish as a foreign language, teacher training, teacher training, organization of pedagogical tests and exhibitions for cultural or educational purposes; editing of educational videos and texts

Goods & Services

Publications. Teaching Spanish as a foreign language, teacher training, arranging educational tests and exhibitions for cultural or educational purposes; Publication of texts and educational videos. Scientific and technological services as well as research and design services relating thereto; Industrial analysis and research; Design and development of computers and computer software.

Abstract

The invention relates to a novel biomarker for the diagnosis, prognosis and monitoring of early-onset colorectal cancer, the gene NOMO-1 or any of the expression products thereof. As such, the invention also relates to an in vitro method of diagnosis, prognosis and monitoring of early-onset colorectal cancer, in which said biomarker must be quantified in a biological sample containing tumour cells.

IPC Classes  ?

• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

This document mainly discloses a method and a device for sound enhancement, both aspects of the invention hereby described are directed to cochlear implants. The method for sound enhancement and the sound enhancement device comprising a component adapted to carry out said method are based on processing the envelope for frequency bands of the acoustic signal captured, said amplification is directed to the gain value of the amplification according to an amplitude of an output signal of the other sound processor.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• H04R 25/00 - Deaf-aid sets

Abstract

The present invention relates to the preparation of particles by micro-encapsulation with albumin of liposomes of different composition and zeta potential prepared by methods using organic solvents but also in their absence, and without extreme conditions of temperature and/or pressure, useful as carriers of active ingredients with potential interest in the field of medicine.

IPC Classes  ?

• A61K 9/127 - Liposomes

Abstract

The invention relates to a control set on a handlebar-steered vehicle, which comprises a handlebar (1) to which is secured a controller (5) that comprises: a body (6) connected to the handlebar (1); a portion (19) for securing the body (6) to the handlebar (1); a control unit (7); input elements (8, 9, 10, 11, 12) for inputting data into the control unit (7); a communications unit (16), for the control unit (7) to communicate with input elements and signalling elements (13, 14, 15); a wireless communication module (17) in the communications unit (19), for the control unit (7) to communicate wirelessly with a portable electronic device (4); signalling elements (13, 14, 15) for indicating various events or statuses of the controller (5) and/or the portable electronic device (4); and a battery (18). The control set allows a portable electronic device to be wirelessly controlled without needing to release the handlebar (1).

IPC Classes  ?

• B62J 6/16 - Arrangement of switches
• B62J 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

The optical system comprises: means (110) for introducing a controlled negative or positive chirp to an incoming ultrashort laser pulse to be characterized (101); a nonlinear optical medium (120) through which said chirped ultrashort laser pulse (111) is propagated, wherein as a result of said propagation: different chirp values are introduced in the ultrashort laser pulse (111) at different propagation distances along the nonlinear optical medium (120), and a transverse nonlinear signal (125) is generated in a direction perpendicular to the propagation axis; analyzing means (130) configured for recording a single-shot spectral image of said generated transverse nonlinear signal (125); and a processing module (140) comprising one or more processors configured to execute a numerical iterative algorithm to said single-shot spectral image to retrieve the electric field, amplitude and phase, of the ultrashort laser pulse (101).

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• H01S 3/11 - Mode locking; Q-switching; Other giant-pulse techniques, e.g. cavity dumping
• G01J 3/36 - Investigating two or more bands of a spectrum by separate detectors
• G02F 1/35 - Non-linear optics
• G02F 1/37 - Non-linear optics for second-harmonic generation

Abstract

The optical system comprises: means (110) for introducing a controlled negative or positive chirp to an incoming ultrashort laser pulse to be characterized (101); a nonlinear optical medium (120) through which said chirped ultrashort laser pulse (111) is propagated, wherein as a result of said propagation: different chirp values are introduced in the ultrashort laser pulse (111) at different propagation distances along the nonlinear optical medium (120), and a transverse nonlinear signal (125) is generated in a direction perpendicular to the propagation axis; analyzing means (130) configured for recording a single-shot spectral image of said generated transverse nonlinear signal (125); and a processing module (140) comprising one or more processors configured to execute a numerical iterative algorithm to said single-shot spectral image to retrieve the electric field, amplitude and phase, of the ultrashort laser pulse (101).

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• G02F 1/35 - Non-linear optics
• G02F 1/37 - Non-linear optics for second-harmonic generation

Abstract

The present invention relates to an electric bicycle (1) which solves the problems of the prior art, in that, using a low-cost solution, it enables the user to have information about both his surroundings and the operational data of the bicycle in a single display device (i.e., a human-machine interface). To this effect, the bicycle has a controller (71) associated with a motor and power supply means, and includes a communication module (70), said communication module (70) including a device communication sub-module (76) by means of which the communication module communicates with the controller (71), and an interface communication sub-module (77) by means of which the communication module (70) communicates with external devices.

IPC Classes  ?

• B62M 6/45 - Control or actuating devices therefor

Abstract

This document mainly discloses a method and a device for sound enhancement, both aspects of the invention hereby described are directed to cochlear implants. The method for sound enhancement and the sound enhancement device comprising a component adapted to carry out said method are based on processing the envelope for frequency bands of the acoustic signal captured, said amplification is directed to the gain value of the amplification according to an amplitude of an output signal of the other sound processor.

IPC Classes  ?

• H04R 25/00 - Deaf-aid sets
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Goods & Services

Bleaching preparations and other substances for laundry use; Cleaning, polishing, scouring and abrasive preparations; Soaps; Perfumery; Essential oils; Cosmetics; Hair lotion; Dentifrices; Cosmetic kits. Industrial oils and greases; Lubricants; Dust absorbing, wetting and binding compositions; Fuels (including motor spirit) and illuminants; Candles and wicks for lighting. Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides; Herbicides. Common metals and their alloys; Metal building materials; Transportable buildings of metal; Materials of metal for railway tracks; Non-electric cables and wires of common metal; Ironmongery, small items of metal hardware; Pipes and tubes of metal; Safes; Ores; Works of art of common metal; Rings of common metal for keys; Trophies of common metal; Statues and figures (statuettes) of common metal; Memorial plates and plates, of metal. Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking (supervision), life-saving and teaching apparatus and instruments; Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; Apparatus for recording, transmission or reproduction of sound or images; Magnetic data carriers, recording discs; Compact discs, DVDs and other digital recording media; Mechanisms for coin-operated apparatus; Cash registers; Calculators; Data processing equipment; Computers; Computer software; Fire-extinguishing apparatus; Cinematographic films; Video films; Computer games programmes (software); Electronic publications, downloadable; Video game cartridges; Spectacles (optics); Sunglasses; Sports glasses; Spectacle cases. Vehicles; Apparatus for locomotion by land, air or water. Precious metals and their alloys; Costume jewellery and jewellery; Precious stones; Horological and chronometric instruments; Works of art of precious metal; Prize cups of precious metals; Statues and figurines (statuettes) of precious metal; Pins being jewelry; Ornamental pins; Tiepins; Brooches (jewellery); Key rings [trinkets or fobs]; Badges of precious metal; Cuff links; Cases for jewellery and clocks and watches; Jewelry cases [caskets or boxes]; Commemorative shields of precious metal; Plates; Medals; Commemorative coins. Paper; Paperboard; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters; Office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Printers' type; Printing blocks; Printed publications; Books; Magazines (periodical); Newspapers; Newspapers; Inkstands; Document files [stationery]; Pencils; Drawing sets; Engravings; Bookends; Boxes of cardboard or paper; Posters; Catalogues; Forms, printed; Calendars; Seals [stamps]; Fountain pens; Stickers and marker pens (stationery). Hides; Imitation leather; Animal skins, hides; Trunks(luggage); Valises; Umbrellas; Parasols; Walking sticks; Whips; Saddlery; Backpacks; Handbags; Wallets; Key cases (leather goods); Attache cases; Handbags; Beach bags; Holdalls; Sport bags; Purses. Furniture; Mirrors (silvered glass); Frames; Works of art and decorations of wood, wax, gypsum, plaster or of plastics; Boxes of wood or plastic; Statues and figures (statuettes) of wood, wax, plaster or of plastics. Household or kitchen utensils and containers; Combs; Sponges; Brushes (except paintbrushes); Brush-making materials; Articles for cleaning purposes; Steelwool; Unworked or semi-worked glass (except glass used in building); Glassware, porcelain and earthenware not included in other classes; Tableware; Beverage glassware; Plates; Works of art, of porcelain, terra-cotta or glass; Statues and figures (statuettes) of porcelain; Terra cotta or Crystal; Piggy banks; Soap boxes; Toilet cases; Commemorative plates. Cordage; Strings; Nets; Tents; Tarpaulins; Sails; Sacks and bags (not included in other classes); Padding and stuffing materials (except of rubber or plastics); Raw fibrous textile materials. Fabrics; Textiles not included in other classes; Bed covers; Table covers; Handkerchiefs of textile; Towels of textile; Travelling rugs [lap robes]; Flags (not of paper); Face towels [made of textile materials]. Clothing; Footwear; Headgear; Scarves; Belts (clothing); Neckties; Gloves of clothing; Neckerchiefs; handkerchiefs (clothing); Caps [headwear]; Rainwear. Lace trimmings; Embroidery; Buttons; Hook fastenings; Eyelets; Pins; Needles; Artificial flowers; Decorative articles for the hair; Badges [buttons] (Ornamental novelty -); Badges for wear, not of precious metal; Badges [buttons] (Ornamental novelty -); Pins, other than jewellery [jewelry (Am)]; Brassards; Brooches [clothing accessories]; Hair pins; Hair bands; Slides (hair grips); Ribbons; Braids. Toys; Toys; Gymnastic and sporting articles not included in other classes; Decorations for Christmas trees; Board games; Card games; Dolls; Plush toys; Electronic games; Hand-held electronic video games. Meat; Fish; Poultry, not live; Game; Meat extracts; Preserved, frozen, dried and cooked fruits and vegetables; Jellies, jams, compotes; Eggs; Edible oils and fats; Milk; Milk products. Rice; Bread, pastry and confectionery; Ices; Sugar, honey, treacle; Yeast, baking-powder; Salt; Mustard; Vinegar, sauces (condiments); Spices; Ice; Coffee; Tea; Cocoa; Artificial coffee; Tapioca; Sago; Flour; Cereals. Beer; Mineral and aerated waters and other non-alcoholic beverages; Fruit beverages and fruit juices; Syrups and other preparations for making beverages. Advertising; Business management; Business administration; Office functions; Sales promotion for others; Retailing in shops and sale via global computer networks of soaps, perfumery, cosmetics, foodstuffs, beverages, key rings, trophies, statues, figurines, compact discs, DVDs and other digital recording media, computer software and electronic games, publications, video games, spectacles, jewellery, clocks and watches, shields, plaques, medals, plates, commemorative coins, musical instruments, stationery and office requisites, smokers' articles; Retailing in shops and sale via global computer networks of travelling bags, rucksacks, pocket wallets, handbags, leatherware, boxes, ornaments, household utensils and containers, cutlery, glassware, porcelain, earthenware, ceramics, terra-cotta or crystal, bed covers, table covers, clothing, footwear, headgear, clothing accessories, games, playthings, gymnastic and sporting articles, candles and apparatus for lighting; Organisation of exhibitions and trade fairs for commercial or advertising purposes, sponsorship searches and advertising, including promotion of the goods and services of others via sponsorship agreements and licence agreements relating to international sporting events, business management in relation to the licensing of goods and services for others. Insurance; Financial affairs; Monetary affairs; Real estate affairs; Financial sponsorship; Memorial fund raising; Letting of showrooms; Rental of buildings and real estate. Construction, construction of buildings and roads, public installations, civil engineering projects; Installation of fittings for buildings; Installation of environmental engineering systems; Installation of computer systems; Maintenance and repair of industrial machinery and vehicles. Telecommunications; Communication via computer networks, transmission and broadcasting of music, transmission and broadcasting of radio and television programmes, broadcasting of programmes via global computer networks, broadcasting of video and audio programmes via the internet, distribution of audio-visual data or images via global computer networks or the internet, wire service and information (news). Transport; Packaging and storage of goods; Travel arrangement; Travel and passenger transportation, Sightseeing, tour guide and excursion services, Sightseeing [tourism], Delivery of goods, Distribution of energy, Electricity supply and distribution, Distribution of oil and gas, Organisation of the storage, transport and distribution of hydrocarbons. Education; Providing of training; Entertainment; Sporting and cultural activities; Arranging and conducting of conferences, congresses, seminars; Organization of exhibitions for cultural or educational purposes; Tuition; Education information; Recreation facilities (Providing -); production of shows, radio and television programmes; Editing and publication of texts (other than publicity texts), books and magazines; Music and film editing; Publication of electronic books and journals on-line; Providing on-line electronic publications, not downloadable; Organization of cultural; Organisation of trade fairs for cultural purposes; Organisation of cultural or sporting awards. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software. Services for providing food and drink; Temporary accommodation; Bar services, Cafeteria and Catering; Accommodation bureaux [hotels, boarding houses]. Medical services; Veterinary services; Hygienic and beauty care for human beings or animals; Agriculture, horticulture and forestry services. Legal services; Security services for the protection of property and individuals; Legal administration of licences, Granting of licences to others for the use of industrial property rights and copyright, Licensing of industrial property rights and copyright.

Abstract

The invention relates to peptides comprising the fragment 266-283 of connexin 43 of SEQ ID n° 1, and to the use of said peptides for the treatment of diseases associated with cell proliferation, in particular for the treatment of gliomas. The invention also relates to the pharmaceutical composition(s) and the kit comprising said peptides.

IPC Classes  ?

• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 35/00 - Antineoplastic agents

Abstract

The invention relates to the use of metalloprotease inhibitors for the treatment of polycystic liver diseases (PCLDs). The invention especially relates to the use of Marimastat as the preferred metalloprotease inhibitor for the treatment of PCLDs. Treatment with Marimastat can inhibit hepatic cystogenesis by blocking the metalloproteolytic hyperactivity of the polycystic cholangiocytes.

IPC Classes  ?

• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/203 - Retinoic acids
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

The present invention concerns a demodulation device for demodulating an electromagnetic signal derived from a modulation of a carrier signal, comprising at least one demodulator and coupling means (21) for coupling said modulated carrier signal to said demodulator(s) so as to generate a demodulated signal representative of the carrier modulation. The demodulator(s) comprise a self-switching device (SSD) (1) with a conductive substrate and insulating features defining in said conductive substrate an elongated channel. The present invention concerns also a method for demodulating an electromagnetic signal.

IPC Classes  ?

• H03D 7/10 - Transference of modulation from one carrier to another, e.g. frequency-changing by means of discharge tubes having more than two electrodes the signals to be mixed being applied between different pairs of electrodes
• H03D 1/10 - Demodulation of amplitude-modulated oscillations by means of non-linear two-pole elements of diodes

Abstract

The present invention concerns a mixing device for mixing electromagnetic signals, comprising at least one mixer and coupling means for coupling electromagnetic signals to said mixer(s) so as to generate mixed signals with frequency content corresponding to sum and/or difference of frequencies of coupled electromagnetic signals. The mixer(s) comprise(s)a self-switching device (SSD) (1) with a conductive substrate and insulating features defining in said conductive substrate an elongated channel, said elongated channel providing a charge carrier flow path in said conductive substrate between first and second areas. The present invention concerns also a method for mixing electromagnetic signals.

IPC Classes  ?

• H03D 7/02 - Transference of modulation from one carrier to another, e.g. frequency-changing by means of diodes
• H03D 9/06 - Transference of modulation using distributed inductance and capacitance
• H01Q 21/24 - Combinations of antenna units polarised in different directions for transmitting or receiving circularly and elliptically polarised waves or waves linearly polarised in any direction

Abstract

The invention allows optimization of hearing and improvement of communication in users with auditory dysfunction (hypoacusis), permitting enhanced acoustic sensitivity and tuning in noisy surroundings and environments, e.g. cafeterias, bars, restaurants, etc. More specifically, the binaural sound-processing system (1) described herein is based on a combined, coordinated operating mode involving two sound processors (20), each installed so as to correspond to the user's ears. Thus, by means of this special link between the operating modes of the two sound processors (20), it is possible to obtain, at the output of each, a final stimulation pattern that is more "natural" and adjusted to the real acoustic conditions of each moment or situation.

IPC Classes  ?

• H04R 25/00 - Deaf-aid sets

Abstract

The invention relates to an isolated peptide derived from endoglin, characterised in that the amino acid sequence thereof comprises a cleavage site GL for extracellular matrix metalloproteinase 14 (MMP-14 or MT1- MMP), and in that it can block the proteolytic cleavage of the endoglin using MMP-14. The invention also relates to a pharmaceutical composition characterised in that it comprises, by way of active ingredient, at least one endoglin-derived peptide as defined above. The invention further relates to the use of at least one of said endoglin-derived peptides or a pharmaceutical composition as defined above for the treatment of a disorder or disease associated with soluble endoglin (sEng) or with MMP-14.

IPC Classes  ?

• C07K 14/705 - Receptors; Cell surface antigens; Cell surface determinants
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 9/12 - Antihypertensives

Goods & Services

Paper, cardboard and goods made from these materials not included in other classes; photographs; stationery; artists' materials; paintbrushes; instructional or teaching material (except apparatus); plastic materials for packaging (not included in other classes); periodical publications, books, magazines (periodicals), newspapers and periodicals, manuals, catalogs, posters, pamphlets. Education; training; entertainment services; sporting and cultural activities; organization and conducting of conferences, seminars and congresses, organization of exhibitions for cultural or educational purposes, production of radio and television programs and shows, publication of texts other than advertising texts, publication of books and magazines, publication of electronic books and journals online, providing online electronic publications (not downloadable). Scientific and technological services and research and design related thereto; industrial analysis and research services; design and development of computer hardware and software.

Goods & Services

Paper, cardboard and goods made from these materials not included in other classes; photographs; stationery; artists' materials; paintbrushes; instructional or teaching material (except apparatus); plastic materials for packaging (not included in other classes); periodical publications, books, magazines (periodicals), newspapers and periodicals, manuals, catalogs, posters, pamphlets. Education; training; entertainment services; sporting and cultural activities; organization and conducting of conferences, seminars and congresses, organization of exhibitions for cultural or educational purposes, production of radio and television programs and shows, publication of texts other than advertising texts, publication of books and magazines, publication of electronic books and journals online, providing online electronic publications (not downloadable). Scientific and technological services and research and design related thereto; industrial analysis and research services; design and development of computer hardware and software.

Abstract

The invention relates to the field of medical diagnostics. In particular, it relates method and kits for identification and classification of IgE-related diseases, e.g. Type I hypersensitivity, as well as for monitoring of treatment efficacy, for instance anti-IgE therapy. Provided is a multi-color flow cytometric method for analyzing memory B cell and plasma cell subsets in a biological sample, comprising staining the sample with a panel of fluorochrome-conjugated antibodies comprising antibodies against IgM, IgA, IgG, IgD and IgE; an antibody against a B cell marker and an antibody against the CD38 antigen; subjecting the sample to flow cytometry and gating for lymphocytes based on forward scatter and side scatter pattern; gating the lymphocytes for expression of the B cell specific marker and CD38 to discriminate between CD38dim memory B cells and CD38hi plasma cells; and quantitating the IgE+ cells within the memory B cell population and/or the plasma cell population by the negative selection of cells expressing IgM, IgA, IgG and/or IgD and the positive selection of IgE expressing cells.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention relates to a transgenic non-human animal whose genome comprises a polynucleotide comprising a hematopoietic stem cell-specific transcriptional regulatory sequence operatively linked to a heterologous nucleotide sequence encoding a human MALT1 protein and which recapitulates most of the features of human B-cell lymphomas, such as Mucosa-Associated Lymphoid Tissue (MALT) lymphoma or activated B-cell like Diffuse Large B-Cell Lymphoma (ABC-DLBCL). Further, the invention also relates to methods for the screening of compounds with pharmacologically relevant activities using said transgenic non-human animals.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• A01K 67/027 - New breeds of vertebrates

Abstract

The present invention relates to the use of cardiotrophin-1 (CT-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1.

IPC Classes  ?

• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61P 39/02 - Antidotes

Abstract

This invention relates to methods to detect the presence of cancer infiltration of the Central Nervous System (CNS) based on the detection of soluble proteins, preferably, in cerebrospinal fluid samples and vitreous fluid. The invention also relates to kits to perform the methods of the invention.

IPC Classes  ?

• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer

Abstract

The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.

IPC Classes  ?

• G01N 33/483 - Physical analysis of biological material
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Goods & Services

Advertising; Business management; Business administration; Office functions, wholesaling and retailing in shops, and via global computer networks, of jewellery, horological instruments, printed matter, stationery, printed publications, books, clothing, footwear, headgear; Procurement services for others [purchasing goods and services for other businesses]; Import-export agencies; Commercial information agencies; Rental of vending machines; Rental of advertising space; Rental of photocopying machines; Publicity material rental; Office machines and equipment rental; Rental of advertising time on communication media; Consumers (Commercial information and advice for -) [consumer advice shop]; Market research; Sponsorship search; Business research; Commercial information agencies; Business investigations; Price comparison services; Presentation of goods on communication media, for retail purposes; News clipping services; Consumers (Commercial information and advice for -) [consumer advice shop]; Shop window dressing; Rental of vending machines; Marketing studies; Organization of exhibitions for commercial or advertising purposes; Organisation of trade fairs for commercial or advertising purposes; Commercial information and advice for consumers [consumer advice shop]; Business investigation; Financial valuation of standing timber; Modelling for advertising or sales promotion; Office machines and equipment rental; Opinion polling; Organization of exhibitions for commercial or advertising purposes; Psychological testing for the selection of personnel; Price comparison services; Presentation of goods on communication media, for retail purposes; Economic forecasting; Publicity material rental; Rental of advertising space; Public relations services; Opinion polling; Evaluation of standing timber; Evaluation of wool; Presentation of goods on communication media, for retail purposes; Auctioneering services. Education; Providing of training; Entertainment; Sporting and cultural activities; Modelling for artists; Rental of radio and television sets; Rental of video recorders; Rental of movie projectors and accessories; Rental of video cameras; Rental of show scenery; Rental of audio equipment; Rental of skin diving equipment; Rental of lighting apparatus for theatrical sets or television studios; Rental of sports equipment, except vehicles; Rental of video cameras; Rental of skin diving equipment; Calligraphy services; Layout services, other than for advertising purposes; Timing of sports events; Rental of show scenery; Rental of sports equipment, except vehicles; Education information; Entertainment information; Rental of stage scenery; Timing of sports events; Videotaping; Recreation information; Sign language interpretation; Sign language interpretation; Ticket agency services [entertainment]; Microfilming; Digital image processing; Publication of books; Publication of texts, other than publicity texts; Publication of electronic books and journals on-line; Recreation information; Booking of seats for shows; Providing on-line electronic publications, not downloadable; Rental of stage scenery; Rental of radio and television sets; Translation and interpretation; Rental of video recorders. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software; Computer rental; Computer rental; Rental of web servers; Rental of software; Graphic arts designing; Authenticating works of art; Consultancy in the field of computers; Conversion of data or documents from physical to electronic media; Packaging design; Graphic art design; Packaging design; Dress designing; Cloud seeding.

Goods & Services

Advertising; Business management; Business administration; Office functions, wholesaling and retailing in shops, and via global computer networks, of jewellery, horological instruments, printed matter, stationery, printed publications, books, clothing, footwear, headgear; Procurement services for others [purchasing goods and services for other businesses]; Import-export agencies; Commercial information agencies; Rental of vending machines; Rental of advertising space; Rental of photocopying machines; Publicity material rental; Office machines and equipment rental; Rental of advertising time on communication media; Consumers (Commercial information and advice for -) [consumer advice shop]; Market research; Sponsorship search; Business research; Commercial information agencies; Business investigations; Price comparison services; Presentation of goods on communication media, for retail purposes; News clipping services; Consumers (Commercial information and advice for -) [consumer advice shop]; Shop window dressing; Rental of vending machines; Marketing studies; Organization of exhibitions for commercial or advertising purposes; Organisation of trade fairs for commercial or advertising purposes; Commercial information and advice for consumers [consumer advice shop]; Business investigation; Financial valuation of standing timber; Modelling for advertising or sales promotion; Office machines and equipment rental; Opinion polling; Organization of exhibitions for commercial or advertising purposes; Psychological testing for the selection of personnel; Price comparison services; Presentation of goods on communication media, for retail purposes; Economic forecasting; Publicity material rental; Rental of advertising space; Public relations services; Opinion polling; Evaluation of standing timber; Evaluation of wool; Presentation of goods on communication media, for retail purposes; Auctioneering services. Education; Providing of training; Entertainment; Sporting and cultural activities; Modelling for artists; Rental of radio and television sets; Rental of video recorders; Rental of movie projectors and accessories; Rental of video cameras; Rental of show scenery; Rental of audio equipment; Rental of skin diving equipment; Rental of lighting apparatus for theatrical sets or television studios; Rental of sports equipment, except vehicles; Rental of video cameras; Rental of skin diving equipment; Calligraphy services; Layout services, other than for advertising purposes; Timing of sports events; Rental of show scenery; Rental of sports equipment, except vehicles; Education information; Entertainment information; Rental of stage scenery; Timing of sports events; Videotaping; Recreation information; Sign language interpretation; Sign language interpretation; Ticket agency services [entertainment]; Microfilming; Digital image processing; Publication of books; Publication of texts, other than publicity texts; Publication of electronic books and journals on-line; Recreation information; Booking of seats for shows; Providing on-line electronic publications, not downloadable; Rental of stage scenery; Translation and interpretation; Rental of video recorders. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software; Computer rental; Computer rental; Rental of web servers; Rental of software; Graphic arts designing; Authenticating works of art; Consultancy in the field of computers; Conversion of data or documents from physical to electronic media; Packaging design; Graphic art design; Dress designing; Packaging design; Dress designing; Cloud seeding.

Goods & Services

Precious metals and their alloys and goods in precious metals or coated therewith, not included in other classes; Jewellery, precious stones; Horological and chronometric instruments; Ornaments of jet; Clock hands; Ornaments of jet; Jet, unwrought or semi-wrought; Watch chains; Clock cases; Watch crystals; Dials for clock and watch making; Spinel [precious stones]; Housings for clocks and watches; Jewel cases; Cases for watches [presentation]; Watchstraps; Copper tokens; Jewelry boxes; Key rings [split rings with trinket or decorative fob]; Clock hands; Clockworks; Movements for clocks and watches; Medals; Coins; Watch springs; Olivine [gems]; Pearls made of ambroid [pressed amber]; Semi-precious stones; Watchstraps; Pendulums [clock- and watchmaking]; Watch chains; Watch crystals; Watchstraps; Watch cases; Watch springs; Barrels [clock- and watchmaking]; Agates; Anchors [clock- and watchmaking]. Paper, cardboard and goods made from these materials, not included in other classes; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Printers' type; Printing blocks; Composing frames [printing]; Architectural models; Self-adhesive tapes for stationery or household purposes; Trays for sorting and counting money; Money holders; Balls for ball-point pens; Garbage bags of paper or of plastics; Bags for microwave cooking; Wristbands for the retention of writing instruments; Sheets of reclaimed cellulose for wrapping; Adhesive tapes for stationery or household purposes; Money holders; Composing sticks; Packaging material made of starches; Mounting photographs (Apparatus for -); Steatite [tailor's chalk]; Hand labelling appliances; Photograph stands; Mounting photographs (Apparatus for -); Passport covers; Checkbook covers; Packaging material made of starches; Packaging material made of starches; Galley racks [printing]; Tailors' chalk; Printers' blankets, not of textile; Architectural models; Marking chalk; Bags for microwave cooking; Passport holders; Graining combs; House painters' rollers; Engraving plates; Printers' reglets; House painters' rollers; Chaplets; Holders for checkbooks [cheque books]; Marking chalk; Vignetting apparatus. Clothing, footwear, headgear; Non-slipping devices for footwear; Pockets for clothing; Studs for football boots; Non-slipping devices for footwear; Heelpieces for footwear; Fittings of metal for footwear; Tips for footwear; Welts for footwear; Shirt yokes; Shirt yokes; Boot uppers; Heelpieces for footwear; Footwear uppers; Linings (Ready-made -) [parts of clothing]; Fittings of metal for footwear; Heelpieces for stockings; Footwear uppers; Shirt fronts; Insoles; Tips for footwear; Heelpieces for stockings; Dress shields; Footwear soles; Heels; Studs for football boots [shoes]; Welts for footwear; Visors [headwear].

Goods & Services

Precious metals and their alloys and goods in precious metals or coated therewith, not included in other classes; Jewellery, precious stones; Horological and chronometric instruments; Ornaments of jet; Clock hands; Ornaments of jet; Jet, unwrought or semi-wrought; Watch chains; Clock cases; Watch crystals; Dials for clock and watch making; Spinel [precious stones]; Housings for clocks and watches; Jewel cases; Cases for watches [presentation]; Watchstraps; Copper tokens; Jewelry boxes; Key rings [split rings with trinket or decorative fob]; Clock hands; Clockworks; Movements for clocks and watches; Medals; Coins; Watch springs; Olivine [gems]; Pearls made of ambroid [pressed amber]; Semi-precious stones; Watchstraps; Pendulums [clock- and watchmaking]; Watch chains; Watch crystals; Watchstraps; Watch cases; Watch springs; Barrels [clock- and watchmaking]; Agates; Anchors [clock- and watchmaking]. Paper, cardboard and goods made from these materials, not included in other classes; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Printers' type; Printing blocks; Composing frames [printing]; Architectural models; Self-adhesive tapes for stationery or household purposes; Trays for sorting and counting money; Money holders; Balls for ball-point pens; Garbage bags of paper or of plastics; Bags for microwave cooking; Wristbands for the retention of writing instruments; Sheets of reclaimed cellulose for wrapping; Adhesive tapes for stationery or household purposes; Money holders; Composing sticks; Packaging material made of starches; Mounting photographs (Apparatus for -); Steatite [tailor's chalk]; Hand labelling appliances; Photograph stands; Mounting photographs (Apparatus for -); Passport covers; Checkbook covers; Packaging material made of starches; Packaging material made of starches; Galley racks [printing]; Tailors' chalk; Printers' blankets, not of textile; Architectural models; Marking chalk; Bags for microwave cooking; Passport holders; Graining combs; House painters' rollers; Engraving plates; Printers' reglets; House painters' rollers; Chaplets; Holders for checkbooks [cheque books]; Marking chalk; Vignetting apparatus. Collar protectors, cuffs, heelpieces for stockings, ready-made linings (parts of clothing), shirt yokes, boot uppers, fittings of metal for shoes and boots, heels, non-slipping devices for boots and shoes, tips for footwear, welts for boots and shoes, hat frames (skeletons), footswear uppers, heelpieces for boots and shoes.

Abstract

The invention relates to a method for determining the presence of renal damage in an individual and also to a method for detecting one or several proteins selected from the list comprising Reg3B, fetuin B, Ras-related GTP- binding protein A, serine protease inhibitor A3L, subunit 1 of COP9, gamma subunit of ATP synthase, gelsolin, ribonuclease UK114, aminoacylase 1A, alpha-enolase, keratin 5, parvalbumin alpha, ribonuclease 4 or serine protease inhibitor A3K. The renal damage may be acute renal failure. Said renal pathologies may be caused by the administration of a nephrotoxic agent, wherein the nephrotoxic agent may be an aminoglycoside antibiotic such as gentamicin, or cisplatin. The invention also provides means to differentiate the renal damage or renal failure induced by gentamicin from that induced by cisplatin, through the biochemical analysis of the urinary level of Reg3B and/or gelsolin, or fragments thereof.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Goods & Services

Precious metals and their alloys and goods in precious metals or coated therewith, not included in other classes; Jewellery, costume jewellery, precious stones; Horological and chronomatic instruments. Paper, cardboard and goods made from these materials, not included in other classes; Printed matter; Bookbiding material; Photographs; Articles of stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Printers' type; Printing block. Clothing, footwear, headgear. Games, toys, and playthings; Gymnastic and sporting articles not included in other classes; Christmas tree decorations. Education; Providing of training; Providing amusement services; Sporting and cultural activities. Scientific and technological services and research and design relating thereto; Industrial analysis and reseach services; Design and development of computer hardware and software.

Abstract

The invention relates to a method of determining the risk of developing acute renal failure (ARF) in an individual, or of determining an ARF, and a method of predicting the progression of an ARF, by detecting and/or quantifying the protein Ganglioside GM2 Activator Protein (GM2AP). The failure can be due to the administration of at least one nephrotoxic agent, wherein the nephrotoxic agent can be an aminoglycoside antibiotic as for example gentamicin.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

Use of a casein-derived peptide with antioxidant and ACE-inhibitory activity in vitro and antihypertensive activity in mammals, and compositions thereof. This peptide may be use as active ingredient in pharmaceutical, cosmetic and/or dermatological compositions, dietary supplements or as food ingredient. Also relates with composition comprising this peptide in specific concentrations, and fermented compositions, including fermented dairy product, that have enhanced stability under various storage conditions, and their uses.

IPC Classes  ?

• A61K 38/01 - Hydrolysed proteins; Derivatives thereof
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals

Abstract

The present invention lies in the field of biotechnology. It relates to a method for evaluating whether a compound is effective in the prevention and/or treatment of a disease associated with T-cell lymphomas.

IPC Classes  ?

• A01K 67/027 - New breeds of vertebrates
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method for designing an individual anti-tumour therapy for a patient based on the detection of the levels of the Hsp90 protein responsible for resistance to a drug or a mixture of anti-tumour drugs that inhibit receptors IGF1R/KIT. The invention also relates to the use of Hsp90 protein inhibitors for the production of drugs for the treatment of tumours resistant to IGF1R/KIT inhibitors, the resulting pharmaceutical compositions and the use thereof on Ewing's sarcoma tumours.

IPC Classes  ?

• A61K 35/00 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution
• C07D 225/06 - Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
• A61P 35/00 - Antineoplastic agents

Goods & Services

Precious metals and their alloys and goods in precious metals or coated therewith, not included in other classes; Jewellery, precious stones; Horological and chronomatic instruments; Jewellery boxes; Coins. Leather and imitations of leather, and goods made of those materials and not included in other classes; Animal skins, hides; Trunks and travelling bags; Umbrellas, parasols and walking sticks; Whips, harness and saddlery; Backpacks; Sport bags. Household and kitchen utensils and containers; Combs and sponges; Brushes (except paint brushes); Material for brush-making; Articles for cleaning purposes; Steelwool; Unworked or semi-worked glass (except glass used in building); Glassware, porcelain and earthware not included in other classes. Textiles and textile goods, not included in other classes; Bed-covers and table-covers. Clothing, footwear, headgear. Games and toys; Gymnastic and sporting articles not included in other classes; Decorations for Christmas trees.

Goods & Services

Precious metals and their alloys and goods in precious metals or coated therewith, not included in other classes; Jewellery, precious stones; Horological and chronomatic instruments; Jewellery boxes; Coins. Paper, cardboard and goods made from these materials, not included in other classes; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Printers' type; Printing blocks. Leather and imitations of leather, and goods made of those materials and not included in other classes; Animal skins, hides; Trunks and travelling bags; Umbrellas, parasols and walking sticks; Whips, harness and saddlery; Backpacks; Sport bags. Household and kitchen utensils and containers; Combs and sponges; Brushes (except paint brushes); Material for brush-making; Articles for cleaning purposes; Steelwool; Unworked or semi-worked glass (except glass used in building); Glassware, porcelain and earthware not included in other classes. Textiles and textile goods, not included in other classes; Bed-covers and table-covers. Clothing, footwear, headgear. Games and toys; Gymnastic and sporting articles not included in other classes; Decorations for Christmas trees. Education; Providing of training; Entertainment; Sporting and cultural activities; Publication of books; Publication of texts, other than publicity texts; Publication of electronic books and journals on-line; Providing on-line electronic publications, not downloadable; Rental of video recorders. Scientific and technological services including research and design relating thereto; Industrial analysis and research; Design and development of computers and software.

Abstract

The invention relates to the use of non-human mammals which have been genetically modified to eliminate the Vav2 gene and/or to reduce expression of the levels of its messenger RNA or of the protein that encodes the Vav2 molecule. This animal model, or cell lines derived therefrom, can be used in various types of experimental methods for the identification and characterization of drugs that can be used to prevent and/or treat diseases or disorders which are common in humans such as essential hypertension, cardiac and arterial hyperplasia, tachycardia, kidney failure and fibrotic processes. This model is also useful for the identification of genetic, biochemical, physiological and other kinds of markers which have prognostic value in poorly characterized human diseases such as those mentioned above.

IPC Classes  ?

• A01K 67/027 - New breeds of vertebrates
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 15/12 - Genes encoding animal proteins

Abstract

Antituberculosis agents of the general formula (I) and their use for the manufacture of pharmaceutical compositions.

IPC Classes  ?

• A61P 31/06 - Antibacterial agents for tuberculosis
• A61K 31/132 - Amines, e.g. amantadine having two or more amino groups, e.g. spermidine, putrescine
• A61K 31/133 - Amines, e.g. amantadine having hydroxy groups, e.g. sphingosine
• A61K 31/396 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The invention relates, in general, to markers of obesity and lipodystrophy. In particular, the expression level of the SLUG gene or its expression products can be used as such a marker. Furthermore, the invention additionally relates to the use of SLUG as a therapeutic and diagnostic target for these pathologies. The invention further relates to a method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The invention relates to the identification of markers for cancer stem cells. These markers can be used in a number of different ways, including diagnosis and therapy. In particular, the invention relates to a method of detecting, identifying and/or quantifying cancer stem cells, the method comprising the step of assessing the level of expression; the activity; or the sequence of the SLUG, OVOLl and/or OVOL2 gene, promoter and/or expression product in a cell.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates, to cancer development; more specifically, leukaemia. In particular, the invention relates to transgenic non-human animals comprising in their genome a human oncogene which can be regulated exogenously by an effector substance. The invention further relates to transgenic non-human animals comprising in their genome the BCR-ABLp 190 gene. In addition the invention relates to the use of the transgenic non-human mammals of the invention for the discovery and development of compounds for the prevention and/or treatment of cancer.

IPC Classes  ?

• A01K 67/027 - New breeds of vertebrates
• C07K 14/82 - Translation products from oncogenes
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The invention relates to the in vitro use of NF-kB inhibitors to induce the selective depletion of alloreactive T-lymphocytes, to derivative pharmaceutical compositions and to uses of same. More specifically, the invention relates to the in vitro use of NF-kB inhibitors to induce the selective depletion of alloreactive T-lymphocytes following mixed culture. In particular, the invention relates to the in vitro use of NF-kB inhibitors, preferably proteosome inhibitors and more preferably still bortezomib inhibitors in mixed lymphocyte cultures (MLR) in order to induce the selective depletion of alloreactive T-lymphocytes and to reduce the production of Th1 cytokines. The invention also relates to pharmaceutical compositions and the therapeutic use thereof.

IPC Classes  ?

• A61K 31/69 - Boron compounds
• A61K 38/05 - Dipeptides

Abstract

A method that generates new flow cytometry data files with a potentially infinite number of dimensions is described. First two or more separate flow cytometry data files containing information about events measured in different aliquots from the same sample are fused. Then, the magnitude of the values and a corresponding uncertainty measure of the differing variables between one or more of the original data files which have been fused are estimated, for each individual event contained in the fused data file, for which that variable was not directly measured in the flow cytometer. The new data file containing both data actually measured in the flow cytometer for each event of the individual original data files fused and the estimated data for those parameters not measured in a group of events from one or more of the original data files are reconstructed multidimensionally.

IPC Classes  ?

• G06F 15/00 - Digital computers in general; Data processing equipment in general

Goods & Services

Paper, cardboard and goods made from these materials, not included in other classes; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packing (not included in other classes); Printers' type; Printing blocks. Educational, teaching and training, entertainment, sporting and cultural services; Translation and interpretation; Publication of books; Publication of texts, other than publicity texts; Publication of electronic books and journals on-line; Providing on-line electronic publications, not downloadable; Rental of video recorders. Scientific and technological services and research and design relating thereto, industrial analysis and research, design and development of computers and software, legal services.