Abstract

The present invention relates to a robot that can walk or climb over flat objects (100) or non-flat objects (200) arranged horizontally, vertically or inclined. The robot incorporates at least two clamping units (300) that can tilt around a cylindrical articulation (19) and are intended to support or clamp objects (100, 200). Each of the clamping units (300) comprises two locomotion modules (1) that can move linearly with respect to one another guided by the cylindrical articulation (19). Each locomotion module comprises a frame (4) and an articulated leg (50) located on a side of the frame (4) that is actuated via motors (70, 71, 72) to facilitate its displacement and climbing movement.

IPC Classes  ?

• B62D 57/024 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members specially adapted for moving on inclined or vertical surfaces
• B25J 11/00 - Manipulators not otherwise provided for
• A62C 27/00 - Fire-fighting land vehicles

Abstract

This application discloses Protein Tyrosine Phosphatase Receptor Kappa (PTPRK) inhibitors for use in medicine, in particular for use in the treatment and/or prevention of a condition selected from the group consisting of overweight, obesity, hyperglycaemia, diabetes, hyperlipidaemia, a non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma, and combinations thereof. Also disclosed is a pharmaceutical composition comprising a PTPRK inhibitor or a combination of PTPRK inhibitors for use in the treatment and/or prevention of a condition selected from the group consisting of overweight, obesity, hyperglycaemia, diabetes, hyperlipidaemia, a non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma, and combinations thereof.

IPC Classes  ?

• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/06 - Antihyperlipidemics
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to 5-fluorouracil (5-FU) for use thereof as an antiviral, alone or in combination with peptides that inhibit binding between nsp10 and nsp14 and between nsp10 and nsp16, acting against viruses of the family Coronaviridae, preferably SARS-CoV-2.

IPC Classes  ?

• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
• A61P 31/14 - Antivirals for RNA viruses

Abstract

22 emissions, with the possibility of using recycled materials and additions, ultimately avoiding the need to use cement when forming a prefabricated part.

IPC Classes  ?

• C04B 22/06 - OxidesHydroxides
• C04B 24/04 - Carboxylic acidsSalts, anhydrides or esters thereof
• B28B 1/04 - Producing shaped articles from the material by tamping or ramming
• B28B 1/08 - Producing shaped articles from the material by vibrating or jolting
• B28B 1/10 - Producing shaped articles from the material by vibrating or jolting and applying pressure otherwise than by the use of presses
• E04C 2/04 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of concrete or other stone-like materialBuilding elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of asbestos cement

Abstract

The present invention relates to an in vitro method for the diagnosis of Alzheimer's disease, comprising the determination of an apolipoprotein E (ApoE)-based biomarker selected from the group consisting of: presence, amount, or concentration ApoE having a size of 34 kDa in an ApoE aggregate having a size of 100 kDa; ratio of ApoE dimers/monomers detected in a native electrophoresis assay; and presence of ApoE dimers detected in a native electrophoresis assay. The present invention also relates to a kit for diagnosing Alzheimer's disease comprising reagents for carrying out the method of the invention.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention describes a rectoscope (1) formed by a body (3), a handle (2) and a head (4), connected together, wherein the body (3) is elongate and hollow, so as to contain an interior channel (6) that passes therethrough longitudinally, and is connected to the handle (2) by means of an enlarged area (5) including a nozzle (9). According to the invention, the body (3) is curved in an intermediate area and comprises a plurality of conduits (7), parallel to the interior channel (6), which extend through the body (3) and lead to the enlarged area (5), the conduits being interconnected, and to respective holes (8) at the opposite end, wherein the interior channel (6) contains a video camera and a light source, such that the rectoscope (1) is designed to pump air towards the conduits (7) and to transmit images to a receiver.

IPC Classes  ?

• A61B 1/32 - Devices for opening or enlarging the visual field, e.g. of a tube of the body
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor

Abstract

The present invention relates to the discovery of compounds of formula (I), possessing activity as modulators of metabotropic glutamate 6 receptor (mGlu6) whose modulatory activity on the receptor may be controlled by irradiation with suitable light resulting in the optical control of receptor biological function, to pharmaceutical compositions comprising said compounds of formula (I), and to the use of said compounds and pharmaceutical compositions as a medicament, in particular for the treatment and/or prevention of retinitis pigmentosa, and/or for the enhancement of visual performance in healthy subjects.

IPC Classes  ?

• C07D 213/81 - AmidesImides
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/4402 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
• A61K 31/4427 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems
• A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
• A61P 27/02 - Ophthalmic agents

Abstract

The invention relates to a rehabilitation device comprising a control board with a master microcontroller, provided with a broker, virtual reality goggles and microcontrollers associated with a pedal assembly and devices for measuring biometric data. In this way, the master microcontroller is connected to an administration web server for monitoring the data from the biometric data measuring devices, and the personalised tracking and management of sessions using pedal assembly control software, as well as the content output via the virtual reality goggles. Advantageously, the pedal assembly includes electronics to increase and decrease the pedalling intensity by means of a braking system, including a servomotor, a potentiometer, an electric power supply.

IPC Classes  ?

• A63B 22/06 - Exercising apparatus specially adapted for conditioning the cardio-vascular system, for training agility or co-ordination of movements with rotating cycling movement

Abstract

The present invention relates to a method for manufacturing particle boards made of lignocellulosic material that produces an end product having the properties of current industrial particle boards that are also formaldehyde-free. Furthermore, carrying out a drying step prior to crushing, by means of applying average pressure and heat levels, is not required for their manufacture, so that the cost of the end product does not increase.

IPC Classes  ?

• B27N 3/02 - Manufacture of substantially flat articles, e.g. boards, from particles or fibres from particles
• B27N 3/18 - Auxiliary operations, e.g. preheating, humidifying, cutting-off
• B27N 3/20 - Moulding or pressing characterised by using platen-presses

Abstract

The invention relates to a rehabilitation robot with a hybrid actuator for an aquatic environment, which includes aquatic propulsion means (2) with at least one inlet (24) for water (1) and at least one outlet (25) for water (1) at pressure, electromechanical propulsion means (3), and control means (32) of the aquatic propulsion means (2) and of the electromechanical propulsion means (3), wherein the aquatic propulsion means (2) and the electromechanical propulsion means (3) are joined to at least one mechanical joint (5), all this in order to provide a rehabilitation robot specially designed to operate in an aquatic environment, using the water (1) in the environment as a propulsion means.

IPC Classes  ?

• A61H 9/00 - Pneumatic or hydraulic massage
• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements

Abstract

The present invention relates to an in vitro method for the diagnosis of Alzheimer's disease, comprising the determination of an apolipoprotein E (apoE)-based biomarker selected from the group consisting of: presence, amount or concentration of apoE having a size of 34 kDa in an apoE aggregate having a size of 100kDa; ratio of apoE dimers/monomers detected in a native electrophoresis assay; and presence of apoE dimers detected in a native electrophoresis assay. The present invention also relates to a kit for diagnosing Alzheimer's disease comprising reagents for carrying out the method of the invention.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

said method comprises using a pointing diffraction mask and a tracking diffraction mask, wherein each pointing diffraction mask is generated in combination with a tracking diffraction mask in said diffractive element.

IPC Classes  ?

• H04B 10/00 - Transmission systems employing electromagnetic waves other than radio-waves, e.g. infrared, visible or ultraviolet light, or employing corpuscular radiation, e.g. quantum communication
• G02B 5/32 - Holograms used as optical elements
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
• H01S 3/101 - Lasers provided with means to change the location from which, or the direction in which, laser radiation is emitted
• H01S 3/16 - Solid materials
• H04B 7/185 - Space-based or airborne stations

Abstract

The invention relates to a device for positioning a radiofrequency surface antenna (2) on a sample (1), used in the field of Nuclear Magnetic Resonance (NMR) imaging studies. The invention improves the placement of the surface antenna (2) on the sample (1) to be studied in an easy, precise and reproducible way, and therefore it comprises a chassis (6) intended to be fixed to a sample bed and to hold a preamplifier (3), a ball-joint articulated arm (7), connected to the chassis (6) by means of a first ball joint (8), and a coupler (11), connected to the ball-joint articulated arm (7) at an end opposite the chassis (6) by means of a second ball joint (12), said chassis intended to receive the surface antenna (2).

IPC Classes  ?

• G01R 33/34 - Constructional details, e.g. resonators

Abstract

Disclosed are a system and method for assessing specific joint movements of the human body. The method comprises: acquiring (201) joint movements (202) performed by a user (114) in an exercise; obtaining (203) first joint-movement patterns (204) of expert users, corresponding to the exercise carried out; detecting and classifying (205) the exercise by means of a combined analysis of the joint movements (202) acquired, using a pre-trained automatic learning model; obtaining (207) second joint-movement patterns (208) of expert users, corresponding to a detected exercise (206); calculating (209) a first average distance (X1) between the acquired joint movements (202) and the first joint-movement patterns (204); calculating (210) a second average distance (X2) between the acquired joint movements (202) and the second joint-movement patterns (208); and assessing (211) the quality of the exercise performed by the user (114) according to the first average distance (X1), the second average distance (X2) and the detected exercise (206).

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06N 20/10 - Machine learning using kernel methods, e.g. support vector machines [SVM]
• G06N 3/00 - Computing arrangements based on biological models

Abstract

The present invention relates to NRF2-βTrCP interaction inhibitors with general formula I and its derivate salts for use in the treatment of NRF2-related diseases caused by chronic inflammation and oxidative stress. More specifically the present invention relates to NRF2- βTrCP interaction inhibitors with specific formula I and its derivate salts for treating diseases of the liver related with chronic inflammation and oxidative stress, such as fatty liver disease.

IPC Classes  ?

• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

Disclosed is a device (1) for protection against eye infections, which is intended to be placed on eyepieces (12) of a microscopy device (2), wherein the device (1) comprises an open cylinder (3) intended to cover the eyepiece (12) of the microscopy device (2), the open cylinder (3) being provided with a proximal portion (4), a distal portion (5), an internal portion (6) and an external portion (7). According to the invention, the proximal portion (4) is provided with an internal ring (8), and the internal portion (6) comprises at least a first notch (9) that acts as a stop against the eyepiece (12) and which is intended to hold an interchangeable transparent sheet (11) placed on the proximal portion (4) inside the open cylinder (3), between the internal ring (8) and the first notch (9), allowing individual use and personal protection against any microscopy device in an effective and practical manner.

IPC Classes  ?

• G02B 25/00 - EyepiecesMagnifying glasses
• G02B 21/00 - Microscopes

Abstract

The present invention relates to the protein IFIT5 for use as a medicinal product, especially for the treatment of viral diseases in aquatic animals, especially against viral haemorrhagic septicaemia virus (VHSH).

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/46 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention refers to a cell suspension comprising at least 90% of CD45RA- memory T cells, characterized in that the memory T cells are derived from blood of convalescent patients recovered from an infection with a respiratory pathogen and have specific lymphocyte antiviral reactivity against its antigens, for use in the treatment of immunocompromised patients suffering from lymphopenia.

IPC Classes  ?

• A61P 31/14 - Antivirals for RNA viruses
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

The invention relates to a process for obtaining a solid heterogeneous mixture which comprises mixing plant fibres or particles, compost, and insect residues, adding a liquid solution comprising vermicompost extract and at least one organic acid, introducing the mixture into a mould, and carrying out at least one pressure-temperature cycle consisting of applying a pressure of 15-25 kg/cm2 to said mixture and subjecting it to a temperature of 100-130ºC for 10-30 minutes. The invention also relates to a solid heterogeneous mixture comprising plant fibres or particles, compost, insect residues, vermicompost and at least one organic acid, to the product comprising it and to uses thereof in agriculture, gardening, landscaping, for soil protection, for revegetation and for releasing fertiliser into the soil.

IPC Classes  ?

• E02D 17/20 - Securing of slopes or inclines
• E01F 8/02 - Arrangements for absorbing or reflecting air transmitted noise from road or railway traffic specially adapted for sustaining vegetation or for accommodating plants
• A01G 24/44 - Growth substratesCulture mediaApparatus or methods therefor characterised by their structure in block, mat or sheet form
• A01G 24/22 - Growth substratesCulture mediaApparatus or methods therefor based on or containing natural organic material containing plant material
• B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless

Abstract

in-vitroin-vitroin-vitro method; and an Alzheimer's disease diagnosis kit, which comprises reagents for determining the sAPPα and/or sAPPβ glycosylation pattern in a biological sample.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention relates to a method, system and device for transmitting information from an optical communication transmitter to a receiving station via a laser beam and for alignment of said laser beam emitted from said optical communication transmitter with said receiving station, wherein: - said optical communication transmitter is displaced relative to said receiving station and comprises a laser, a radio receiver, a microprocessor and a liquid crystal on silicon spatial light modulator comprising a diffractive element, whereby said laser beam is emitted from said laser and is projected over an area by diffraction and reflection using said liquid crystal on silicon spatial light modulator, wherein said laser and said diffractive element are controlled by said microprocessor, wherein said laser beam has a longitudinal axis parallel to the propagation path of said laser beam, - said receiving station comprises a photodiode receiver for detecting said transmitted laser beam and a radio transmitter, and said method comprises using a pointing diffraction mask and a tracking diffraction mask, wherein each pointing diffraction mask is generated in combination with a tracking diffraction mask in said diffractive element.

IPC Classes  ?

• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection
• H04B 10/118 - Arrangements specific to free-space transmission, i.e. transmission through air or vacuum specially adapted for satellite communication

Abstract

Disclosed is a mobile robot that can be moved in a plane, which has two bodies (2, 3) connected together by means of a passive hinge (4) having two degrees of freedom and by means of linear actuators (5, 6), each of which is formed by a variable-length bar connected to both bodies (2, 3) by rotation hinges (5', 5'', 6', 6''), the linear actuators (5, 6) being arranged crosswise with respect to each other. The mobile robot also includes a controller (7) connected to the linear actuators (5, 6) to control and actuate same, and the bodies (2, 3) have temporary adhesion means (8) for temporary adhesion to a sliding plane of the robot (1) and which are also connected to the controller (7).

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 1/02 - Manipulators positioned in space by hand articulated or flexible
• B25J 1/08 - Manipulators positioned in space by hand movably mounted in a wall
• B25J 17/02 - Wrist joints

Abstract

The invention relates to a maximum urine flow meter, which comprises a urine-collecting container (2) having an upper opening (3) for receiving urine (9), and a bottom drain (4), the collecting container (2) being intended to accumulate a column of urine having a height that varies according to the difference between system for letting urine into and out of the collecting container through the top opening and the drain, respectively; and a measuring pipe (6) that can be removably coupled in hydraulic connection with the drain (4) of the collecting container (2) to form an angle with collecting container (2), the measuring pipe being provided with a series of holes (7.1 to 7.10) along the length of the underside thereof.

IPC Classes  ?

• A61B 5/20 - Measuring urological functions

Abstract

The invention relates to a robotic rehabilitation device comprising a control unit that can be interconnected with at least one control unit of another robotic rehabilitation device, which allows two or more persons to participate simultaneously in rehabilitation processes or activities carried out using robotic devices, such that there is an interaction between the rehabilitation activities of two or more persons, making the rehabilitation process more enjoyable and easier.

IPC Classes  ?

• A61H 1/02 - Stretching or bending apparatus for exercising
• A63B 23/12 - Exercising apparatus specially adapted for particular parts of the body for limbs, i.e. upper or lower limbs, e.g. simultaneously for upper limbs
• A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
• G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising

Abstract

An interchangeable sensor device for a functional near-infrared spectroscopy system (fNIRS) is a non-invasive device intended to detect changes in the concentration of hemoglobin species on any body surface area. The device includes a plurality of measurement units having different elastic configurations, each intended to be adapted to a specific area of the body, and a control unit for controlling any of the measurement units. Each of the measurement units is equipped with a first connector and the control unit is equipped with a second connector, which connectors allow the control unit to be interchangeably connected to any of the measurement units.

IPC Classes  ?

• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow

Abstract

The present invention relates to a wearable robotised system for the assistance and rehabilitation of the adduction-abduction and flexion-extension movements of the wrist and the pronation-supination movement of the forearm.

IPC Classes  ?

• A63B 23/12 - Exercising apparatus specially adapted for particular parts of the body for limbs, i.e. upper or lower limbs, e.g. simultaneously for upper limbs
• A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
• A61H 1/02 - Stretching or bending apparatus for exercising

Abstract

The present invention concerns, but is not limited to, a device for interrupting the circulation of direct current in the event of an electrical failure, which is connected between a supply source of direct current and an electrical load. The device generally comprises: an output terminal (2) of the device; an input terminal (1) of the device; a shared terminal (3) of the device; a field-effect transistor (4); a current-measuring resistor (5); a failure-current detection circuit (6); a current-measuring circuit (7); a polarisation circuit (8); a trigger circuit (9); a timing circuit (10); an interlock circuit (11); a reset circuit (12); and a power-off command circuit (13). The circuit allows the automatic adjustment of the limit intensity, the failure time, the current limitation time and the full scale of the circuit for measuring failure current.

IPC Classes  ?

• H02H 3/087 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to excess current for DC applications
• H02H 3/02 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection Details
• H03K 17/082 - Modifications for protecting switching circuit against overcurrent or overvoltage by feedback from the output to the control circuit
• G05F 1/573 - Regulating voltage or current wherein the variable actually regulated by the final control device is DC using semiconductor devices in series with the load as final control devices sensing a condition of the system or its load in addition to means responsive to deviations in the output of the system, e.g. current, voltage, power factor for protection with overcurrent detector

Abstract

Bifidobacterium longum infantis infantis CECT 9720, to its cellular components, metabolites and secreted molecules, and to compositions comprising said products, as well as to the use of the strain to prevent and/or treat inflammatory bowel disease and liver inflammation, as well as associated diseases, such as liver cirrhosis.

IPC Classes  ?

• C12N 1/20 - BacteriaCulture media therefor
• A61K 35/745 - Bifidobacteria
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics

Abstract

The invention relates to a neovaginal prosthesis formed by an essentially cylindrical hollow main body comprising a closed upper end and an open lower end, and a securing plate intended to connect to the lower end of the main body.

IPC Classes  ?

• A61F 2/02 - Prostheses implantable into the body
• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts

Abstract

The invention relates to an improved dry additive for gypsum, characterised in that comprises a base of polycarboxylic acid, more specifically citric acid, to which colloidal silicon dioxide is added at a concentration of between 0.8 and 1.2 wt.-% in relation to the acid, wherein the proposed additive is in the form of a dry powder. The quantity by weight of additive to be added to the dry gypsum for the use thereof is between 0.06 and 2 g for every 1000 g of dry gypsum, such that mixing with the gypsum, the properties of which it is attempted to improve, is performed before mixing with water, it being possible to incorporate the additive in the dry gypsum mass during the production of same.

IPC Classes  ?

• C04B 24/04 - Carboxylic acidsSalts, anhydrides or esters thereof
• C04B 22/06 - OxidesHydroxides
• C04B 28/14 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing calcium sulfate cements

Abstract

14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.

IPC Classes  ?

• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• C07D 249/06 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• H02G 3/08 - Distribution boxesConnection or junction boxes
• H02G 3/06 - Joints for connecting lengths of protective tubing to each other or to casings, e.g. to distribution boxEnsuring electrical continuity in the joint
• A61K 31/4192 - 1,2,3-Triazoles
• A61P 27/04 - Artificial tearsIrrigation solutions
• A61P 15/02 - Drugs for genital or sexual disordersContraceptives for disorders of the vagina

Abstract

The present invention discloses the amino-terminal sequence of avian albumin bound to divalent cations such as copper or zinc, and any recombinant or fusion protein comprising said sequence for use thereof as a medicinal product, specifically for treating intoxications caused by organophosphorus compounds. The present invention also describes compositions and methods for treating said type of intoxications. In addition, the present invention discloses the use of said sequences, and peptides comprising same, for the decontamination and/or bioremediation of regions and surfaces contaminated with organophosphorus compounds and for isolating chiral compounds.

IPC Classes  ?

• C07K 14/465 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from birds
• A61K 38/38 - Albumins
• A61P 39/00 - General protective or antinoxious agents

Abstract

The invention relates to an interchangeable sensor device (1) for a functional near-infrared spectroscopy system (fNIRS) which is a non-invasive device intended to detect changes in the concentration of haemoglobin species on any body surface area. The device comprises a plurality of measurement units (200) having different elastic configurations, each intended to be adapted to a specific area of the body, and a control unit (300) for controlling any of the measurement units (200). Each of the measurement units (200) is equipped with a first connector (212) and the control unit (300) is equipped with a second connector (312), which connectors allow the control unit (300) to be interchangeably connected to any of the measurement units (200).

IPC Classes  ?

• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters

Abstract

The invention relates to a neovaginal prosthesis formed by an essentially cylindrical hollow main body comprising a closed upper end and an open lower end, and a securing plate intended to connect to the lower end of the main body.

IPC Classes  ?

• A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts

Goods & Services

Agricultural and aquacultural crops, horticulture and forestry products; Live animals, organisms for breeding; Foodstuffs and fodder for animals. Advertising, marketing and promotional services; Business analysis, research and information services; Business assistance, management and administrative services; Commercial information and advice for consumers [consumer advice shop]; Commercial information and advice for consumers in the choice of products and services; Goods or services price quotations; Retail services in relation to foodstuffs; Consultancy services relating to the procurement of goods and services; Wholesale services in relation to foodstuffs. Agriculture, aquaculture, horticulture and forestry services.

Abstract

The invention relates to compounds having formula (I) wherein A is selected from the group consisting of: a) optionally substituted (C1-C8) alkyl; b) optionally substituted (C3-C6) cycloalkyl; c) optionally substituted (C6-C14) aryl; d) optionally substituted (C6-C14) heteroaryl; e) C(0)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; f) C(0)-(C6-C14) heteroaryl, in which group (C6-C14 ) heteroaryl is optionally substituted; g) CH(OH)-(C6-C14) aryl, in which group (C6-C14) aryl is optionally substituted; and h) CH(OH)-(C6-C14) heteroaryl, in which group (C6-C14) heteroaryl is optionally substituted. The invention also relates to methods for the production of said compounds, to pharmaceutical and veterinary compositions comprising said compounds and to the therapeutic uses thereof, such as for the prevention and/or treatment of dry eye syndrome, vaginal dryness and/or burning mouth syndrome.

IPC Classes  ?

• C07D 249/04 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles
• A61K 31/4192 - 1,2,3-Triazoles

Abstract

The invention relates to derivatives of perylene-3,4:9,10- tetracarboximide of formula I, wherein the meaning of X, R-1, R2, R3, R4, R5, R6 is that indicated in the description, a method for the preparation of said derivatives and the use thereof as detectors of oxidising agents, including oxidising explosives.

IPC Classes  ?

• C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated

Abstract

The invention relates to a device and a method using said device for measuring levels of glucose in blood in a non-invasive manner. For this purpose, resonator microwave antennae are used which are disposed opposite one another with the tongue of the user, whose glucose level is to be measured, positioned between the two antennae. The variations in resonant frequencies in the antennae produced by the changes in the relative permittivity of the medium, the tongue, permit the level of glucose in the user, whose glucose level is to be measured, to be determined on the basis thereof, such that the responses to the changes can be processed via correlation in order to determine said glucose levels.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more

Abstract

The invention relates to a photovoltaic evaporative chimney for cooling a photovoltaic panel, using a current of air on the rear thereof, and for dissipating heat from a cooling cycle. The chimney is divided into two main parts. The first section, known as the evaporative zone, comprises a series of nozzles that spray water that flows parallel to the falling ambient air. As the water is falling a small part is evaporated, the remainder being cooled. This section operates as a small-scale cooling tower. The air that was in contact with the water floats up into the so-called convective zone. This second zone is basically a solar chimney in which the air is heated, causing said air to float. In turn the air rising through the convective section cools the photovoltaic panel, increasing the efficiency thereof. Fig. 1

IPC Classes  ?

• H02S 40/42 - Cooling means
• H01L 31/052 - Cooling means directly associated or integrated with the PV cell, e.g. integrated Peltier elements for active cooling or heat sinks directly associated with the PV cells

Abstract

The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

IPC Classes  ?

• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61K 31/075 - Ethers or acetals
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
• A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/07 - Retinol compounds, e.g. vitamin A
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 38/13 - Cyclosporins

Abstract

The invention relates to a composition comprising a humectant, a first antiseptic, a fixer, a thickener, a colorant and water. The invention also relates to a cadaver comprising a composition according to the invention and/or at least one tag designed to communicate by radiofrequency and to transmit clinical information contained in the tag to a device, as well as to the methods of production and to the uses thereof for medical training, learning or assessment. The invention further relates to simulators and to the uses thereof for medical training, learning or assessment.

IPC Classes  ?

• A01N 1/00 - Preservation of bodies of humans or animals, or parts thereof
• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine

Abstract

The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

IPC Classes  ?

• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61K 31/075 - Ethers or acetals
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
• A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/07 - Retinol compounds, e.g. vitamin A
• A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
• A61K 38/13 - Cyclosporins

Abstract

Disclosed is an ergonomic, anti-stain paint palette, the grip hole of which consists in a support that is situated below the usable surface of the palette in a balanced position.

IPC Classes  ?

• B44D 3/02 - Palettes

Abstract

Method for producing PDI derivatives. The invention relates to a method for producing perylene diimide derivatives of formula I where R1, R2 and R3 have the designation indicated in the description. Said compounds are used to produce dyes, pigments, paints, fluorescent agents, optical devices, electronic devices, electro-optical devices, light-emitting diodes and organic or hybrid photovoltaic cells.

IPC Classes  ?

• C07D 221/18 - Ring systems of four or more rings
• C07D 471/06 - Peri-condensed systems
• C09B 5/62 - Cyclic imides or amidines of peri-dicarboxylic acids of the anthracene, benzanthrene, or perylene series

Abstract

The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61K 31/075 - Ethers or acetals
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
• A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

Abstract

The invention relates to a catheter design characterised by having a variable number of openings (2) in the different drainage rings (3), such that the uniformity of the flow of the fluid through the catheter (1) is facilitated, while the possibility of the openings (2) being obstructed is minimised, and the flow can be redistributed should any of the openings (2) become obstructed, thereby lengthening the useful life of the device. The invention also relates to two possible opening (2) distribution configurations based on described patterns for the distribution of openings (2) in rings (3), differing in terms of the distance between rings (3), the number of openings (2) in each of the rings (3), and the rotation of same.

IPC Classes  ?

• A61M 27/00 - Drainage appliances for wounds, or the like
• A61M 25/00 - CathetersHollow probes

Abstract

The invention relates to a recombinant deoxyribonucleic acid vaccine comprising the sequence that codes for the ectodomain of the G glycoprotein of the viral hemorrhagic septicemia virus (VHSV), the sequence that codes for a signal peptide of the pleurocidin of Limanda limanda and carp β-actin promoter for the treatment and/or prevention of viral hemorrhagic septicemia caused by VHSV. The vaccine of the invention provides protection both by intramuscular administration and intraperitoneal administration.

IPC Classes  ?

• C12N 15/47 - Rhabdoviridae, e.g. rabies viruses, vesicular stomatitis virus
• A61K 39/205 - Rhabdoviridae, e.g. rabies virus

Abstract

The invention relates to the use of the heterodimeric complex of presenilin comprising the N-y C-terminal fragments of same as a biomarker of Alzheimer disease. The invention also relates to a method and to a kit for the diagnosis and/or the prognosis of said disease by means of the use of said biomarker.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The invention relates to a dry additive for gypsum and to the production method thereof. The additive is characterised in that it comprises a base of polycarboxylic acid, specifically citric acid, to which colloidal silicon dioxide is added at a concentration of between 0.8 wt.-% and 1.2 wt.-% in relation to the acid. The additive takes the form of a dry powder that is mixed with the gypsum to be improved prior to mixture with water. The additive can be added to the dry gypsum mass during production. The production method begins with obtaining a base of citric acid in the form of solid crystals, to which colloidal silicon dioxide is added according to the indicated concentration, for subsequent mixing until homogeneous textures and colour are obtained.

IPC Classes  ?

• C04B 24/04 - Carboxylic acidsSalts, anhydrides or esters thereof
• C04B 22/06 - OxidesHydroxides
• C04B 28/14 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing calcium sulfate cements

Abstract

The invention relates to a method for manufacturing particleboard, having the same properties as particleboard made from wood particles or another lignocellulose material, which uses adhesives of any type and which is free of formaldehyde or other chemical or natural adhesives, the manufacture of said particleboard requiring the application of moderate levels of pressure and heat so as not to render the manufacturing cost of the product expensive. The method is primarily characterized in that it comprises a plurality of cycles of combined application of pressure and heat, reaching a temperature of between 90°C and 130°C and a pressure of between 25 and 35 kg/cm2, and the board is allowed to cool at the end of each cycle, one side of said board being moistened with water before application of the next cycle, the side which is moistened being alternated in each cycle.

IPC Classes  ?

• B27N 3/04 - Manufacture of substantially flat articles, e.g. boards, from particles or fibres from fibres

Abstract

The invention relates to the field of starch production for food use, for the production of bioplastic materials by means of the addition of a plasticizer, and for the use of thermomechanical treatments. Concretely, the invention relates to a method for extracting starch from chufa and from the derivatives thereof.

IPC Classes  ?

• C08B 30/04 - Extraction or purification

Abstract

The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

IPC Classes  ?

• A01N 31/08 - Oxygen or sulfur directly attached to an aromatic ring system
• A61K 31/05 - Phenols
• A01N 33/18 - Nitro compounds
• A01N 33/24 - Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds only one oxygen atom attached to the nitrogen atom
• A61K 31/04 - Nitro compounds
• A01N 27/00 - Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• A61K 31/015 - Hydrocarbons carbocyclic
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
• A61K 31/075 - Ethers or acetals
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 31/17 - Amides, e.g. hydroxamic acids having the group N—C(O)—N or N—C(S)—N, e.g. urea, thiourea, carmustine
• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61K 31/221 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
• A61K 31/245 - Amino benzoic acid types, e.g. procaine, novocaine
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 31/357 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61K 31/662 - Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides

Goods & Services

Paper, cardboard and goods made from these materials, not included in other classes; Printed matter; Bookbinding material; Photographs; Stationery; Adhesives for stationery or household purposes; Artists' materials; Paint brushes; Typewriters and office requisites (except furniture); Instructional and teaching material (except apparatus); Plastic materials for packaging (not included in other classes); Printers' type; Printing blocks. Education; Providing of training; Entertainment; Sporting and cultural activities. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software.

Abstract

The invention relates to gelled products such as gelatins for food consumption or wine gums, comprising probiotic microorganisms and, in some of the variants thereof, prebiotic microorganisms, said products being developed from drinks of plant origin such as juices made from fruit, vegetables and cereals, which are subjected to a lactic fermentation process with at least one probiotic strain. The invention also relates to the method for producing such products, consisting of the following basic steps: a) production of a pasteurised or sterilised substrate; b) fermentation of the substrate; c) hydration of the gelatin and dissolution thereof in hot water; d) cooling of the hydrated gelatin; e) mixing of the fermented plant drink with the selected prebiotic and additives; h) homogenisation of the mixture; and g) packaging of the product.

IPC Classes  ?

• A23L 1/0562 - Proteins, e.g. gelatin, collagen
• A23L 1/0532 - from seaweeds, e.g. alginates, agar, carrageenan
• A23L 1/068 - derived from fruit or vegetable juices
• A23L 1/30 - containing additives (A23L 1/308 takes precedence);;

Abstract

The present invention relates to the use of a ligand that is a TRPA receptor antagonist for preparing a drug intended for the treatment or prevention of diseases or disorders produced by bacterial infections or by exposure to bacterial endotoxins.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

Device for measuring the electrical conductivity in fluids with a low flow rate. The present invention consists of a device for measuring, on-line, the electrical conductivity in food fluids, such as mechanical milking, which comprises a measuring chamber separate from the main line of flow in which two toroidal sensors are incorporated, which sensors make it possible to correctly read the electrical conductivity.

IPC Classes  ?

• G01N 33/04 - Dairy products
• G01N 27/07 - Construction of measuring vesselsElectrodes therefor
• A01J 5/013 - On-site detection of mastitis in milk
• A01J 7/00 - Accessories for milking machines or devices

Abstract

The invention relates to triazine-derived compounds, having the capacity to block TRPV1 and the therapeutic and cosmetic uses thereof. More specifically, the authors of the invention have synthesized trisubstituted triazines which are capable of specifically inhibiting the TRPV1 thermoreceptor in its activated state.

IPC Classes  ?

• C07D 251/52 - Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
• C07D 251/70 - Other substituted melamines
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine

Abstract

The present invention relates to a method for determining Alzheimer's disease by detection of glycoproteins carrying the HNK-1 glycoepitope, to a method for determining the progression of Alzheimer's disease and to the use of a kit for implementing said methods.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/46 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase involving cholinesterase
• C12N 9/18 - Carboxylic ester hydrolases

Abstract

The invention relates to peptides that can modulate the activity of TRP receptors and to the use thereof for treating and/or preventing pain, inflammation, pruritus, respiratory tract illnesses and/or disorders, and/or illnesses and/or disorders associated with calcium imbalances.

IPC Classes  ?

• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

The present invention relates to the use of a system of lipid nanoparticles that includes a nucleic acid, a lipid component, a cationic surfactant, an ionic surfactant, a polysaccharide and optionally, a positively charged peptide, for treating and preventing ocular diseases.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 27/02 - Ophthalmic agents

Abstract

The invention relates to therapeutic compositions for the treatment of dry eye and, more specifically, compositions comprising a TRPM8 receptor agonist ligand. In addition, the invention relates to therapeutic compositions for the treatment of epiphora and, more specifically, compositions comprising a TRPM8 receptor antagonist.

IPC Classes  ?

• A61P 15/02 - Drugs for genital or sexual disordersContraceptives for disorders of the vagina
• A61P 27/02 - Ophthalmic agents
• A61K 31/16 - Amides, e.g. hydroxamic acids
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/045 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Abstract

The invention relates to an intracytoplasmic sperm microinjection simulator, designed to provide a learning and training environment for microinjection specialists, providing an adaptive way of improving the handling of the devices as the user gains experience, in order achieve the sensitivity and skill necessary in a real environment. To this end, the proposed system includes adaptable manipulators (2, 3, 4, 5, 6, 7, 8, 9) having different degrees of sensitivity, which interact with an environmental simulation model (11) to provide images of the activity being carried out, the images being shown via a means of graphic representation (13).

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)

Abstract

The invention relates to methods for identifying compounds capable of altering embryonic development, in other words, compounds having embryotoxic or teratogenic activity. Specifically, the invention relates to the capacity of said compounds to alter NTE activity in stem cells, such that said cells can be used to detect chemical compounds having teratogenic or reproduction-altering capacity. The alterations can be at the gene or protein expression level or at enzymatic level. The invention also relates to stem cells modified to express a reporter gene under the control of the NTE gene promoter as well as to the use of said cells for identifying compounds having embryotoxic activity.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells
• C12N 5/074 - Adult stem cells
• C12N 15/12 - Genes encoding animal proteins

Abstract

Method for producing biomimetic electrodes and the uses thereof as amperometric sensors. Method for producing biomimetic electrodes based on a method for electro-assisted deposition of silica layers printed molecularly on electrodes. In addition, the invention relates to said biomimetic electrodes and the use thereof for producing amperometric, voltammetric, impedance or potentmetric sensors for the highly selective detection of substances of environmental, biochemical or food interest.

IPC Classes  ?

• G01N 33/552 - Glass or silica
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• C03C 3/06 - Glass compositions containing silica with more than 90% silica by weight, e.g. quartz

Abstract

The invention relates to a sound-based kinemometer for determining speeds in vehicles, that uses an antenna made up of a linear or multidimensional group of microphones arranged separately and equidistant from one another, or arranged separately and with a proportional distance between them. Use is also made of photocells as sensors for detecting passing vehicles.

IPC Classes  ?

• G01S 3/80 - Direction-finders for determining the direction from which infrasonic, sonic, ultrasonic, or electromagnetic waves, or particle emission, not having a directional significance, are being received using ultrasonic, sonic, or infrasonic waves
• G01P 11/00 - Measuring average value of speed

Abstract

The invention relates to a system for purchasing photographs taken by amusement park cameras of visitors using a park attraction, comprising the sending of an SMS, by means of which digital-format, print-quality photos are received in the purchaser's e-mail account or on a personalised customer webpage from which the purchased photos can be downloaded.

IPC Classes  ?

• G06Q 30/00 - Commerce

Abstract

The present invention concerns a nanostructured hybrid material composed of at least two components: a metallic core, consisting of two or more gold nanoparticles, creating an aggregate or nanocluster of gold and a mould of an inorganic compound, preferably silica, which encases the metallic core, capable of absorbing near-nfrared radiation and the use thereof in a biotechnological application, preferabley, the treatment or prophylaxis of a pathology by photothermal therapy.

IPC Classes  ?

• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• A61N 5/06 - Radiation therapy using light
• B22F 1/00 - Metallic powderTreatment of metallic powder, e.g. to facilitate working or to improve properties

Abstract

The invention relates to the use of snail1 activity inhibiting compounds in the preparation of pharmaceutical compositions intended for the treatment of chondrodystrophies, a method for identifying inhibiting compounds, pharmaceutical compositions, a chondrodystrophy diagnosis method and the applications thereof.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61P 19/00 - Drugs for skeletal disorders

Abstract

The invention relates to the use of a peptide that comprises the amino acid sequence of the epidermal growth factor-like domain (EGF domain) of neuregulin 1 (NRG1), or a functionally equivalent variant or fragment thereof, or of a polynucleotide that codes for said peptide or functionally equivalent fragment or variant, or of a compound that induces the production and/or activity of said NRG1, in the preparation of a pharmaceutical composition for treating disorders caused by changes in the axonal development of neurones in the nervous system.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

The present invention describes how therapeutic compounds with different isoforms of the Nrg1 gene containing the beta variant of the EGF domain are capable of promoting the growth of axons and the development of branching neurones that express receptors for this factor, such as ErbB4 and ErbB3. It also describes the use of said compounds in the preparation of pharmaceutical compositions and applications thereof in disorders involving changes in axonal development, spinal cord lesions, and neurodegenerative and psychiatric disorders.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

Snail is a protein directly involved in the aetiopathogeny of renal fibrosis as well as being a marker for this disease. Therefore, its identification may be used as a renal-fibrosis diagnostic. Also, furthermore, the Snail protein may be of great use in the identification of new drugs for the treatment of renal fibrosis and its gene inhibition as a form of treatment.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys