The present disclosure relates to an ionic liquid (IL)-based formulation comprising inhibitors of NADPH oxidases enzymes (Nox's), preferably isoforms 1 and 4, in particular the specific inhibitor 3-cyclohexyl-5-(2,4-dihydroxybenzylidene)-1-methyl-2-thiohydantoin, for the treatment, therapy or prevention of neurological diseases, in particular Parkinson's diseases.
A61K 31/4166 - 1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
C07D 233/96 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
2.
SELF-EMULSIFYING COMPOSITION, PRODUCTION METHODS AND USES THEREOF
The present disclosure relates to a self-emulsifying composition and/or a stable and homogeneous aqueous oil-in-water emulsion comprising a neutral hydrophilic surfactant and a combination of at least two hydrophobic excipients selected from the following list: glycerol monooleate, miglyol 812; propylene glycol monocaprylate; wherein 90% of the droplets comprise a size of less than 180 nm; and wherein the size of 50% of the droplets ranges from 90-120 nm. A pharmaceutical composition comprising said emulsion is also described.
A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
A61K 31/4166 - 1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
The present disclosure relates to an ionic liquid (IL)-based formulation comprising inhibitors of NADPH oxidases enzymes (Nox's), preferably isoforms 1 and 4, in particular the specific inhibitor 3-cyclohexyl-5-(2,4-dihydroxybenzylidene)-1-methyl-2-thiohydantoin, for the treatment, therapy or prevention of neurological diseases, in particular Parkinson's diseases.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The present disclosure relates to a self-emulsifying composition and/or a stable and homogeneous aqueous oil-in-water emulsion comprising a neutral hydrophilic surfactant and a combination of at least two hydrophobic excipients selected from the following list: glycerol monooleate, miglyol 812; propylene glycol monocaprylate; wherein 90% of the droplets comprise a size of less than 180 nm; and wherein the size of 50% of the droplets ranges from 90-120 nm. A pharmaceutical composition comprising said emulsion is also described.
A61K 31/366 - Lactones having six-membered rings, e.g. delta-lactones
A61K 31/4166 - 1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
5.
Flight propulsion system based on rotary and stationary devices
A flight propulsion system for Vertical Take-Off and Landing (VTOL) and Short Take-Off and Landing (STOL) aircraft, having a two cyclorotors, installed in the front and rear portions of a pair-wings mechanism involving top wing and bottom wing, three degree-of-freedom DOF adjusting mechanism for pair-wings, a dielectric barrier discharge (DBD) plasma actuators, a bar mechanism for pitching oscillation and rotation speed controls and rear cyclorotor, a yawing mechanism for rear cyclorotor, all on each side of the flight vehicle. This propulsion system is particularly useful for VTOL aircraft. The main features are: high controllability and manoeuvrability, low noise and environmental pollutions, VTOL, STOL, hover state flights, marine and ground take-off and landing, high safety, suitable for different aircraft scales and for different missions and purposes, instant altering the flight direction.
CENTITVC - CENTRO DE NANOTECNOLOGIA E MATERIAIS TÉCNICOS FUNCIONAIS E INTELIGENTES (Portugal)
INSTITUTO DE TELECOMUNICAÇÕES (Portugal)
UNIVERSIDADE DA BEIRA INTERIOR (Portugal)
BORGSTENA TEXTILE PORTUGAL UNIPESSOAL LDA (Portugal)
Inventor
Cunha Silva, Ricardo Manuel
Da Silva Midão, Marta Sofia
Seixas Esteves, David
Fernandes Da Silva Andrade Leite, André Filipe
Cruz Peixoto, Pedro Tiago
Teixeira De Sousa Gouveia, Carolina
Tavares Pinho, Pedro Renato
Neto Vieira, José Manuel
Pinto Pires, Diogo Rafael
Marques Silveira, Tagleorge
Loss, Caroline
Brites Sanches Salvado, Luisa Rita
Abstract
The present disclosure relates to an upholstery layered seat cover for a vehicle seat, said cover having a back-rest part which comprises two lateral back-rest bolster parts, wherein the seat cover comprises: a scrim back-layer, a foam layer and a fabric top-layer, wherein the fabric top-layer being an external upholstery layer of the seat cover; and a plurality of planar vital sign sensors arranged between the scrim back-layer and the fabric top-layer, for monitoring vital signs of a user of the car seat, wherein the vital sign sensors comprise: a breathing sensor comprising a transmitter antenna and a receiver antenna; and an additional vital sign sensor selected from a humidity sensor, a pressure sensor or a temperature sensor; wherein the antennas are located on an outer face of one of the lateral back-rest bolster parts and are arranged to transmit and receive towards the user through the bolster where the antennas are located; wherein each of the antennas is a multilayer textile antenna and the additional vital sign sensor is a multilayer textile sensor; wherein the breathing sensor and the additional vital sign sensor share at least a common textile layer.
The present invention is related to a flight propulsion system for Vertical Take-Off and Landing (VTOL) and Short Take-Off and Landing (STOL) aircraft, which comprises a two cyclorotors (1, 8), installed in the front and rear portions of a pair-wings mechanism involving top wing (3) and bottom wing (4), three degree-of-freedom DOF adjusting mechanism (5) for pair-wings, a dielectric barrier discharge (DBD) plasma actuators (6), a bar mechanism (7) for pitching oscillation and rotation speed controls and rear cyclorotor, a yawing mechanism (9) for rear cyclorotor (8), all on each side of the flight vehicle. This propulsion system is particularly useful for VTOL aircraft. The main features of this invention are: high controllability and manoeuvrability, low noise and environmental pollutions, VTOL, STOL, hover state flights, marine and ground take-off and landing, high safety, suitable for different aircraft scales and for different missions and purposes, instant altering the flight direction.
The present invention is related to a flight propulsion system for Vertical Take-Off and Landing (VTOL) and Short Take-Off and Landing (STOL) aircraft, which comprises a two cyclorotors (1, 8), installed in the front and rear portions of a pair-wings mechanism involving top wing (3) and bottom wing (4), three degree-of-freedom DOF adjusting mechanism (5) for pair-wings, a dielectric barrier discharge (DBD) plasma actuators (6), a bar mechanism (7) for pitching oscillation and rotation speed controls and rear cyclorotor, a yawing mechanism (9) for rear cyclorotor (8), all on each side of the flight vehicle. This propulsion system is particularly useful for VTOL aircraft. The main features of this invention are: high controllability and manoeuvrability, low noise and environmental pollutions, VTOL, STOL, hover state flights, marine and ground take-off and landing, high safety, suitable for different aircraft scales and for different missions and purposes, instant altering the flight direction.
This patent application describes a film developed from natural compounds to cover wounds, whose method of application is in the form of individual disposable packages, vials, syringes and/or others. This wound dressing provides a moist environment at the wound site allowing the occurrence of the autolytic debridement. The film incorporates bioactive agents such as acetylsalicylic acid, essential oils, plant extracts and others, which confer antibacterial, antifungal, anti-inflammatory, antioxidant and regenerative properties. The application method is also explored in order to simplify the life of patients, and to minimise pain and discomfort felt by them, during primary care treatment.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
The present invention is related to the process of obtaining CaO-MgO binders and construction products, with reuse of subproducts and/or residues and carbon dioxide, by compression molding. The binders are produced by crushing and grinding. The process of manufacturing the products consists of mixing binders and subproducts and/or residues with residual non-potable water, and curing this mixture with carbon dioxide, under constant humidity, temperature and pressure conditions. The process of hardening is carried out by recirculating carbon dioxide in a closed circuit, followed by drying of the products. The subproducts and/or residues are rich in calcium and magnesium and may be slag from the steel manufacturing industry or sand and mud resulting from the pulp, paper and cardboard production industry. The construction products may include other residues and materials containing silica and aluminum.
Device for applying in a pavement for collecting mechanical energy from a vehicle passing over said pavement for actuating an electromechanical converter for generating electrical energy, said device comprising: an electromechanical converter; a mechanical or mechanical-hydraulic system comprising a crank-linear slide or crank-piston; a base structure for supporting and fixing the device to the pavement; a cover displaceable in vertical axis translation caused by the vehicle passing over, wherein the cover is arranged to actuate the crank-linear slide or crank-piston; a rack-pinion, or a hydraulic cylinder and respective hydraulic circuit having actuator, arranged for converting linear displacement of the linear slide or the piston, respectively, into rotation of a shaft of the electromechanical converter; wherein said cover has a non-horizontal surface profile having a first elevation at a first end and a second elevation at a second end, wherein the first elevation is lower than the second elevation.
F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
F03G 7/08 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for recovering energy derived from swinging, rolling, pitching, or like movements, e.g. from the vibrations of a machine
E01C 9/00 - Special pavingsPavings for special parts of roads or airfields
H02K 7/18 - Structural association of electric generators with mechanical driving motors, e.g.with turbines
The present disclosure concerns the development of a novel stationary phase for the separation of nucleic acids in the context of preparative chromatography, using a chromatographic matrix, preferably a macroporous matrix, particularly an epoxylated methacrylic polymer matrix modified with the immobilized ionic liquid (IL) 1-methylimidazolium chloride as a multimodal ligand.
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
13.
HYBRID SEAT FOR AIR TRANSPORTATION OF PEOPLE WITH REDUCED MOBILITY
The present invention relates to a hybrid movable seat (2) for transporting passengers with reduced mobility during air transportation which functions as a seat in the aircraft and at the same time allows the movement of the passenger inside and outside the aeroplane. The back (3) of the proposed movable seat (2) engages on the back of the fixed seat structure of the aircraft by means of an engagement and disengagement system (6). The movable seat (2) has rotary rear handles (4), armrests (5) that can be raised, four turning wheels (7) and respective locking and braking systems (8) and rotation systems (9) for the wheels, and footrests (10) with the corresponding extendible mechanisms (11).
The present patent application describes a film developed from components of natural origin for covering wounds, the method of application of said film being in the form of individual disposable packaging, ampules, syringes and/or other types of packaging. Said film provides the wound with a moist environment, for natural autolytic debridement to occur. The film incorporates bioactive agents such as, for example, acetylsalicylic acid, essential oils, plant extracts, and other bioactive agents, which confer antibacterial, antifungal, anti-inflammatory, antioxidant and regenerative properties. The method of application is also explored in order to make patients' lives easier and to minimize pain and discomfort experienced by said patients when receiving treatment given as first aid.
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
A61K 36/886 - Aloeaceae (Aloe family), e.g. aloe vera
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
The present invention concerns a device that recycles thermoplastics for the production of filaments for fused deposition modeling devices (FDM) and respective operation method. The triturated thermoplastic is introduced into the feed hopper (4), pushed by a screw activated by the motor (1), inside the jacket (5), the axial force of which is supported by the axial bearing (2). The thermoplastic is melted with the help of electric heating resistors (6) and passes through a degassing zone (7) connected to the vacuum pump (3). The thermoplastic is forced through the extrusion head (8), being cooled in a cooling tray (9) with a circulating water system (12). The diameter of the filament is controlled by the pulling device (11) based on the data obtained in the filament diameter measuring system (10). The whole process is controlled by a microcontroller.
B29C 47/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor (extrusion blow-moulding B29C 49/04)
Device for applying in a pavement for collecting mechanical energy from a vehicle passing over said pavement for actuating an electromechanical converter for generating electrical energy, said device comprising: an electromechanical converter; a mechanical or mechanical-hydraulic system comprising a crank-linear slide or crank-piston; a base structure for supporting and fixing the device to the pavement; a cover displaceable in vertical axis translation caused by the vehicle passing over, wherein the cover is arranged to actuate the crank-linear slide or crank-piston; a rack-pinion, or a hydraulic cylinder and respective hydraulic circuit having an actuator, arranged for converting linear displacement of the linear slide or the piston, respectively, into rotation of a shaft of the electromechanical converter; wherein said cover has a non-horizontal surface profile having a first elevation at a first end and a second elevation at a second end, wherein the first elevation is lower than the second elevation.
F03G 7/08 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for recovering energy derived from swinging, rolling, pitching, or like movements, e.g. from the vibrations of a machine
17.
DEVICE FOR APPLYING IN A PAVEMENT FOR COLLECTING MECHANICAL ENERGY FROM VEHICLES PASSING OVER FOR GENERATING ELECTRICITY
Device for applying in a pavement for collecting mechanical energy from a vehicle passing over said pavement for actuating an electromechanical converter for generating electrical energy, said device comprising: an electromechanical converter; a mechanical or mechanical-hydraulic system comprising a crank-linear slide or crank-piston; a base structure for supporting and fixing the device to the pavement; a cover displaceable in vertical axis translation caused by the vehicle passing over, wherein the cover is arranged to actuate the crank-linear slide or crank-piston; a rack-pinion, or a hydraulic cylinder and respective hydraulic circuit having an actuator, arranged for converting linear displacement of the linear slide or the piston, respectively, into rotation of a shaft of the electromechanical converter; wherein said cover has a non-horizontal surface profile having a first elevation at a first end and a second elevation at a second end, wherein the first elevation is lower than the second elevation.
F03G 7/08 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for recovering energy derived from swinging, rolling, pitching, or like movements, e.g. from the vibrations of a machine
18.
SYSTEM FOR ICE DETECTION/PREVENTION AND FLOW CONTROL BASED ON THE IMPRESSION OF SLIDING PLASMA ACTUATORS WITH DIELECTRIC DISCHARGE BARRIER
The present invention relates to a system for ice detection/prevention and flow control based on the impression of sliding plasma actuators with dielectric discharge barrier. This invention has advantages such as: reduced weight, low maintenance cost, no environmental impact, fully electrical operation and combination of functions (ice detection, de-icing, anti-icing and flow control). The system comprises the following components: exposed AC electrode (1), dielectric layer (2), embedded electrode (3), nanosecond/sliding electrode (4), ground plane (5), AC power source (6), DC power source (7), nanosecond pulse generator (8), monitoring capacitor (9), high-voltage probe (10), control module (11), temperature sensor (12), control signal input module (13) and monitoring system (14). The system detects the formation of ice and generates extensive surface heating that prevents ice from accumulating.
The present invention relates to an ice detection/protection and flow control system based on printing of dielectric barrier discharge sliding plasma actuators. This invention has advantages such as: reduced weight, low maintenance cost, no environmental impact, fully electric operation and combination of functionalities (ice detection, deicing, anti-icing and flow control). The system comprises the following components: exposed AC electrode (1), dielectric layer (2), embedded electrode (3), sliding/nanosecond electrode (4), ground plane (5), AC power supply (6), DC power supply (7), nanosecond range pulse generator (8), monitoring capacitor (9), high voltage probe (10), control module (11), temperature sensor (12), control signal input module (13) and monitoring system (14). The system senses ice formation and generates extensive surface heating to prevent ice accumulation.
Justino Infante Do Nascimento Neves, João Alexandre
Abstract
This invention concerns a multifunctional air transport system made up of: a manoeuvrable modular hybrid airship (1) of variable length and comprising a modular transport gondola (4), and electric lifting rotors (15) embedded in two pairs of variable incidence wings (17), fitted, respectively, to a nose module (20) and a tail module (21); and a berthing tower (2) extensible in height and comprising a rotating landing platform (8), and a mooring mechanism (3) comprising an extensible arm (26) and a mooring mast (25). Together, these elements form a unique concept for the transport of persons and/or cargo, including their boarding/loading and disembark/ unloading.
The present invention concerns an underwater system for energy storage, which resorts to compressed air, directed to adjust in time the generation of electrical energy by large generation systems to the consumption curves. For this purpose, the system comprises a compressed air reservoir of variable-volume (3), a system anchorage component (4), and a union tube (2) connecting the system to a means of energy generation and air compression (1). Therefore, the present invention finds its main application in the adjustment of energy generation associated with floating oceanic wind parks, to be installed far away from coastal regions, or with other energy generation oceanic systems that are subjected to irregular schemes of generation or consumption.
F03B 13/00 - Adaptations of machines or engines for special useCombinations of machines or engines with driving or driven apparatusPower stations or aggregates
F02C 6/16 - Gas-turbine plants having means for storing energy, e.g. for meeting peak loads for storing compressed air
F24H 7/00 - Storage heaters, i.e. heaters in which the energy is stored as heat in masses for subsequent release
patents
