Abstract

The present disclosure describes a control and management system of multiphase streams in subsea oil and gas production modules. The system comprises (i) a phase separator vessel; (ii) mixing lines; (iii) multiphase, single-phase, pressure, and level variation flow rate measuring instruments; (iv) flow rate and pressure sensors; (v) automatic control valves; and (vi) cascade PID pressure, level, and pressure controllers. The present disclosure describes a control and management system of multiphase streams in subsea oil and gas production modules. The system comprises (i) a phase separator vessel; (ii) mixing lines; (iii) multiphase, single-phase, pressure, and level variation flow rate measuring instruments; (iv) flow rate and pressure sensors; (v) automatic control valves; and (vi) cascade PID pressure, level, and pressure controllers. The system control is further carried out by controlling fluid accumulation inventory, controlling the gas-liquid ratio of the stream sent to a first stationary production unit and controlling the gas-liquid ratio of the stream sent to a second stationary production unit so that a maritime field works optimally and without stoppages or bottlenecks.

IPC Classes  ?

• E21B 43/36 - Underwater separating arrangements
• E21B 43/01 - Methods or apparatus for obtaining oil, gas, water, soluble or meltable materials or a slurry of minerals from wells specially adapted for obtaining from underwater installations

Abstract

The present invention relates to a process for capturing CO2 on a large scale using aqueous solutions of zwitterionic bases by contacting a gas stream containing one or more acid gases with said solutions. The internal salts obtained in the present invention have the advantage of not being volatile, being less susceptible to chemical and thermal decomposition, and also have lower absorption enthalpy. The present invention can be used in various industry sectors, such as in the energy sector, for capturing CO2 from exhaust gases, in the chemical sector, for removing CO2 from the gas streams of catalytic processes in which the CO2 can poison the catalysts, and, in particular, in the oil and gas sector, for purifying natural gas.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/62 - Carbon oxides
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• B01D 53/96 - Regeneration, reactivation or recycling of reactants
• C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms

Abstract

The present invention pertains to the technical field of pipe inspection, wherein instrumented pipe inspection tools (“pipeline inspection tools”—pigs) are used to verify the structural integrity of said pipes and describes a pipe inspection tool comprising a tool body and at least two articulated arms, wherein each articulated arm connects the tool body to a sensor and keeps said sensor in direct contact with the inner surface of a pipe.

IPC Classes  ?

• F16L 55/40 - Constructional aspects of the body

Abstract

The present invention provides a pulling system essentially consisting of two sets of feet (11) and a hydraulic cylinder (15). Each set is positioned on one of the sides of the hydraulic cylinder (15). The two sets of feet (11) have a self-locking mechanism. The self-locking mechanism allows each set of feet to act preferentially on one side and exert powerful forces. The invention further provides a flexible reservoir (21) capable of equalizing the pressures inside and outside the medium, allowing the operation of a hydraulic system in an environment that is subjected to any pressure value, provided that it is within the operating range of the components. In addition, the maintenance of a closed circuit ensures that no fluid contamination occurs.

IPC Classes  ?

• F16L 55/32 - Constructional aspects of the propulsion means, e.g. towed by cables being self-contained
• F15B 15/14 - Fluid-actuated devices for displacing a member from one position to another; Gearing associated therewith characterised by the construction of the motor unit of the straight-cylinder type
• F15B 15/18 - Combined units comprising both motor and pump
• F15B 13/02 - Fluid distribution or supply devices characterised by their adaptation to the control of servomotors
• B08B 9/049 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes

Abstract

The present invention comprises a structure with the same external geometry as a generic hook, but with a topology (internal structuring) that allows a greater distribution of deformation energy to all elements of the part, with load transfer to other less stressed regions. When the present invention is subjected to a loading, said flexible parts deform in a pre-specified manner, transferring part of a loading that would be excessive in a given region to another less loaded region, without any power supply or external interference. In this way, the deformation pattern that occurs in the present invention relieves stresses where they are greatest and, at the same time, provides flexibility (compliance), more adequately distributing coupling loads between the various fastening components.

IPC Classes  ?

• E21B 17/01 - Risers

Abstract

A method of treating produced water on offshore platforms and onshore facilities is described. The method can be applied to or integrated into other already-installed processes and/or technologies for the treatment of produced water, being characterized by the combined addition of anionic surfactant and cationic polyelectrolyte for the destabilization and flocculation of oily emulsions characteristic of produced water, preliminarily to the separation steps (hydrocyclones and/or flotators). The different points and alternatives of reagent injection combinations are adaptable to equipment and units already in operation.

IPC Classes  ?

• C02F 1/56 - Macromolecular compounds
• C02F 1/54 - Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities using organic material
• C02F 1/24 - Treatment of water, waste water, or sewage by flotation

Abstract

A method (100) for recovering metallic materials (12) from crystalline silicon photovoltaic modules (10, 102). The method (100) comprises removing (104) aluminium frames (16) and junction boxes from the photovoltaic modules (10, 102) to provide photovoltaic sandwich structures (14). The method (100) further comprises shredding (106) the photovoltaic sandwich structures (14) to form photovoltaic sandwich structure particles (26) and electrostatically separating (108) the photovoltaic sandwich structure particles (26) into a first fraction (30) and a second fraction (32) with an electrostatic separator (28). The method (100) further comprises feeding (114) at least a portion of the second fraction (32) to an electrostatic separator for one or more subsequent electrostatic separations into the first and second fractions (30, 32), wherein the first fraction (30) comprises less than 5 per cent by weight of total polymer particles and is substantially free of glass particles.

IPC Classes  ?

• B02C 23/14 - Separating or sorting of material, associated with crushing or disintegrating with more than one separator
• B03C 7/00 - Separating solids from solids by electrostatic effect
• B03C 7/06 - Separators with cylindrical material carriers
• B09B 3/35 - Shredding, crushing or cutting
• H01G 9/048 - Electrodes characterised by their structure
• H01G 11/22 - Electrodes
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The present disclosure is related to techniques for the inspection of joints and repairs in pipelines. In this scenario, the a method is provided for the inspection of joints in composite pipes and of composite repairs in metallic pipelines, comprising the steps of (i) emitting a series of acoustic wave pulses, at different frequencies, from a collar of acoustic transducers positioned at a predetermined distance from a joint or repair to be inspected, (ii) recording, in a time interval subsequent to the emission, echoes of wave displacements to the repair or joint in each of the transducers in the form of an A-Scan, and (iii) generating a flattened C-Scan image, through a CSM, for each frequency of pulse emission from the collar of acoustic transducers. The disclosure further provides a system for inspection of joints in composite pipes and of composite repairs in metallic pipelines associated with the provided method.

IPC Classes  ?

• G01N 29/06 - Visualisation of the interior, e.g. acoustic microscopy
• G01N 29/24 - Probes
• G01N 29/34 - Generating the ultrasonic, sonic or infrasonic waves
• G01N 29/44 - Processing the detected response signal

Abstract

A nanometric pharmaceutical composition in the form of liposomes or a nanoemulsion containing interference RNA strands comprising one or more of the following specific siRNA sequences: SEQ ID NO: 1; SEQ ID NO: 2; or SEQ ID NO: 3.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 38/46 - Hydrolases (3)
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 9/107 - Emulsions
• A61K 9/127 - Liposomes
• A61P 35/00 - Antineoplastic agents
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

The present invention proposes the use of a tool (13) that is connected to a device for locomotion, such as, for example, a robot, and provided with an umbilical cable (06) to bring about a controlled reaction near the blockage, in order to remove it. In order to carry out that controlled reaction, an injection, and control system is used, which may be a closed loop control system.

IPC Classes  ?

• B08B 9/049 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes
• B08B 13/00 - Accessories or details of general applicability for machines or apparatus for cleaning

Abstract

The present invention relates to a process for capturing CO2 on a large scale using aqueous solutions of zwitterionic bases by contacting a gas stream containing one or more acid gases with said solutions. The internal salts obtained in the present invention have the advantage of not being volatile, being less susceptible to chemical and thermal decomposition, and also have lower absorption enthalpy. The present invention can be used in various industry sectors, such as in the energy sector, for capturing CO2 from exhaust gases, in the chemical sector, for removing CO2 from the gas streams of catalytic processes in which the CO2 can poison the catalysts, and, in particular, in the oil and gas sector, for purifying natural gas.

IPC Classes  ?

• C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
• B01D 53/62 - Carbon oxides
• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• C01B 32/50 - Carbon dioxide

Abstract

The present invention provides a pulling system essentially consisting of two sets of feet (11) and a hydraulic cylinder (15). Each set is positioned on one of the sides of the hydraulic cylinder (15). The two sets of feet (11) have a self-locking mechanism. The self-locking mechanism allows each set of feet to act preferentially on one side and exert powerful forces. The invention further provides a flexible reservoir (21) capable of equalizing the pressures inside and outside the medium, allowing the operation of a hydraulic system in an environment that is subjected to any pressure value, provided that it is within the operating range of the components. In addition, the maintenance of a closed circuit ensures that no fluid contamination occurs.

IPC Classes  ?

• E21B 37/00 - Methods or apparatus for cleaning boreholes or wells
• B08B 9/049 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes
• F16L 55/32 - Constructional aspects of the propulsion means, e.g. towed by cables being self-contained

Abstract

The present invention relates to the use of a peptide to prevent biofilm formation by microorganisms on a surface, wherein said peptide is (i) a peptide consisting of 6 to 37 consecutive amino acids from a peptide of sequence SEQ ID NO: 1, (ii) a peptide of sequence SEQ ID NO: 4, or (iii) a peptidomimetic of (i) or (ii).

IPC Classes  ?

• C07K 14/415 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 29/16 - Biologically active materials, e.g. therapeutic substances
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

The present invention provides a device for removing internal blockage materials (10) from a fluid-conveying line (3), said device comprising a cutting tool (9) activated by a rotary actuator (8), in which: the cutting tool (9) is positioned at the front of the device; and the cutting tool (9) comprises a diameter that is smaller than the internal diameter of the fluid-conveying line (3).

IPC Classes  ?

• B08B 9/051 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes the cleaning devices having motors for powering cleaning tools
• B08B 9/043 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes
• B08B 9/047 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes the cleaning devices having motors for powering cleaning tools
• B23D 79/02 - Machines or devices for scraping

Abstract

The present invention describes an interference flow valve for coolant fluids comprising a valve with the functions of reducing the pressure of the coolant fluid and filtering impurities contained in the air-conditioning or cooling circuit, and also a method for producing said interference flow valve. The present invention is preferably intended for use in the fields of refrigeration and air conditioning.

IPC Classes  ?

• F25B 41/06 - Flow restrictors, e.g. capillary tubes; Disposition thereof
• F25B 41/04 - Disposition of valves
• F25B 41/00 - Fluid-circulation arrangements
• F25B 49/02 - Arrangement or mounting of control or safety devices for compression type machines, plants or systems

Abstract

The present invention describes a composition for gene therapy of the central nervous system comprising non-viral carriers of nanometric size (<1.0 micrometer) complexed with at least one nucleic acid for purposes of gene therapy via nasal administration, having as main target the central nervous system and the processes for obtaining such carriers. The present invention belongs to the field of nanotechnology and consists of aqueous formulations that can be used in the pharmaceutical and medical fields.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• A61P 25/00 - Drugs for disorders of the nervous system
• A01K 67/027 - New breeds of vertebrates
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention proposes the use of a tool, which is connected to a device for locomotion, such as, for example, a robot, and provided with an umbilical cable, to bring about a controlled reaction near blockages for removal thereof. In order to carry out said controlled reaction, an injection and control system is used, which can be a closed loop control system.

IPC Classes  ?

• B08B 3/04 - Cleaning involving contact with liquid
• B08B 9/02 - Cleaning pipes or tubes or systems of pipes or tubes
• B08B 9/027 - Cleaning the internal surfaces; Removal of blockages

Abstract

The present invention proposes the use of a tool, which is connected to a device for locomotion, such as, for example, a robot, and provided with an umbilical cable, to bring about a controlled reaction near blockages for removal thereof. In order to carry out said controlled reaction, an injection and control system is used, which can be a closed loop control system.

IPC Classes  ?

• B08B 3/04 - Cleaning involving contact with liquid
• B08B 9/02 - Cleaning pipes or tubes or systems of pipes or tubes
• B08B 9/027 - Cleaning the internal surfaces; Removal of blockages

Abstract

The present invention relates to the use of a peptide to prevent biofilm formation by microorganisms on a surface, wherein said peptide is (i) a peptide consisting of 6 to 37 consecutive amino acids from a peptide of sequence SEQ ID NO: 1, (ii) a peptide of sequence SEQ ID NO: 4,or (iii) a peptidomimetic of (i) or (ii).

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/415 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants

Abstract

An article of manufacture includes a first graphene layer, a second graphene layer over the first graphene layer, the second graphene layer oriented at a first interlayer twist angle with respect to the first graphene layer and bonded by interlayer covalent bonds to the first graphene layer, and a third graphene layer over the second graphene layer, the third graphene layer oriented at a second interlayer twist angle with respect to the second graphene layer and bonded by interlayer covalent bonds to the second graphene layer. A multi-layer graphene article includes at least three graphene layers, each graphene layer being oriented at an interlayer twist angle with respect to an adjacent graphene layer and bonded by interlayer covalent bonds to the adjacent graphene layer.

IPC Classes  ?

• B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
• B32B 18/00 - Layered products essentially comprising ceramics, e.g. refractory products
• B32B 38/10 - Removing layers, or parts of layers, mechanically or chemically
• C01B 32/186 - Preparation by chemical vapour deposition [CVD]
• C01B 32/182 - Graphene
• B32B 37/00 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding
• C01B 32/194 - After-treatment
• H01B 1/04 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of carbon-silicon compounds, carbon, or silicon
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

The present invention describes an extractive oxidation process for removing contaminants from hydrocarbon streams using an ionic liquid combined with an organometallic ionic complex of iron(II), which comprises a complex of iron(II) cation with an ionophilic binder, catalyst of iron(II) with ionophilic binder in its molecular structure, oxidation of which is performed with an oxidizing agent and is catalysed by the organometallic iron(II) complex present in the phase of the ionic liquid. Besides maintaining its characteristics of selective solvent of oxidizing compounds, the ionic liquid combined with the organometallic complex of iron(II) with catalytic ionophilic binder of the oxidizing agent, stimulating the reactive phenomenon taking place in the ionic liquid phase, with the effect that the iron remains stable in the ionic liquid phase, without being leached into the oily phase. This measure results in a considerable improvement in removal of the heteroatoms from the hydrocarbon medium.

IPC Classes  ?

• B01J 35/12 - Liquids or melts
• C10G 27/10 - Refining of hydrocarbon oils, in the absence of hydrogen, by oxidation with oxygen or compounds generating oxygen in the presence of metal-containing organic complexes, e.g. chelates, or cationic ion-exchange resins
• C10G 27/12 - Refining of hydrocarbon oils, in the absence of hydrogen, by oxidation with oxygen or compounds generating oxygen with oxygen-generating compounds, e.g. per-compounds, chromic acid, chromates
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides

Abstract

The present invention relates to a rigid metal pipe with thicker ends (T, T1, T2), to a method and to a system for manufacturing these rigid metal pipes (T, T1, T2) and a submarine riser made from these rigid metal pipes (T, T1, T2) that is intended for use in the fields of offshore production, regardless of the water depth of the environment and/or of the contaminants in the fluid produced.

IPC Classes  ?

• E21B 17/01 - Risers
• E21B 17/02 - Couplings; Joints
• B23K 20/12 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating the heat being generated by friction; Friction welding
• F16L 13/04 - Welded joints with arrangements preventing overstressing

Abstract

The present invention relates to an intervention drive pig comprising an umbilical. In this scenario, the present invention provides an intervention drive pig comprising an umbilical, wherein the umbilical (6) is manufactured from a low-density material, wherein the umbilical (6) comprises an external covering of material having a low coefficient of friction.

IPC Classes  ?

• F16L 55/32 - Constructional aspects of the propulsion means, e.g. towed by cables being self-contained
• B08B 9/049 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes

Abstract

The present invention relates to an intervention drive pig comprising an umbilical. In this scenario, the present invention provides an intervention drive pig comprising an umbilical, wherein the umbilical (6) is manufactured from a low-density material, wherein the umbilical (6) comprises an external covering of material having a low coefficient of friction.

IPC Classes  ?

• F16L 55/32 - Constructional aspects of the propulsion means, e.g. towed by cables being self-contained
• B08B 9/049 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes

Abstract

The present invention describes compounds, the use of compounds in the preparation of a pharmaceutical composition, and a pharmaceutical composition comprising the compounds according to formula A, neutral or ionized derivatives or analogues thereof, for senolytic prevention and/or therapy purposes. Specifically, the present invention comprises the compounds of formula A, neutral or ionized derivatives or analogues thereof, for senolytic prevention and/or therapy purposes, based on selective apoptosis of senescent cells.

IPC Classes  ?

• C07D 493/00 - Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
• C07D 311/00 - Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
• C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents
• A61P 39/00 - General protective or antinoxious agents
• A61P 39/06 - Free radical scavengers or antioxidants

Abstract

The present invention relates to the synthesis of a class of fluorophores developed by combining the salicylidene and benzazole classes, and to the compound produced and the technical use thereof in the form of a light emitting diode (WOLED). Said synthesis produces a compound which has advantageous optical and electronic properties and high potential for use in light emitting diodes. The present invention further relates to a process for producing white organic light emitting diodes (WOLEDs) as well as to the diodes produced.

IPC Classes  ?

• C07D 277/62 - Benzothiazoles
• C07D 513/12 - Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups , or in which the condensed system contains three hetero rings
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to techniques for inspections of joints and repairs in pipework. In this context, the present invention provides a method for inspecting joints in composite pipes and composite repairs in metal pipework, which comprises the steps of (i) emitting a series of acoustic-wave pulses, at different frequencies, from an acoustic-transducer collar (4) positioned at a predetermined distance from the joint (5) or repair (1) to be inspected, (ii) recording, over a time interval after emission, the echoes of the movements of the waves to the repair or joint at each of the transducers of the acoustic-transducer collar (4) in A-scan form and (iii) generating a plan-view C-scan image, using the CSM method, for each frequency at which pulses are emitted from the acoustic-transducer collar (4). The invention further provides a system for inspecting joints in composite pipes and composite repairs in metal pipework associated with the above-described method.

IPC Classes  ?

• G01N 29/07 - Analysing solids by measuring propagation velocity or propagation time of acoustic waves
• G01N 29/26 - Arrangements for orientation or scanning
• G01N 29/11 - Analysing solids by measuring attenuation of acoustic waves

Abstract

The present invention provides a device for removing internal blockage materials (10) from a fluid-conveying line (3), said device comprising a cutting tool (9) activated by a rotary actuator (8), wherein: the cutting tool (9) is positioned at the front of the device; and the cutting tool (9) comprises a diameter that is smaller than the internal diameter of the fluid-conveying line (3).

IPC Classes  ?

• B08B 9/027 - Cleaning the internal surfaces; Removal of blockages
• B08B 9/04 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes
• B08B 9/045 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes the cleaning devices being rotated while moved
• B08B 9/047 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes the cleaning devices having motors for powering cleaning tools
• B08B 9/051 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes the cleaning devices having motors for powering cleaning tools
• B23D 1/08 - Planing or slotting machines cutting by relative movement of the tool and workpiece in a horizontal straight line only by movement of the tool
• B23D 21/00 - Machines or devices for shearing or cutting tubes
• B23D 21/14 - Machines or devices for shearing or cutting tubes cutting inside the tube

Abstract

The present invention provides a device for removing internal blockage materials (10) from a fluid-conveying line (3), said device comprising a cutting tool (9) activated by a rotary actuator (8), wherein: the cutting tool (9) is positioned at the front of the device; and the cutting tool (9) comprises a diameter that is smaller than the internal diameter of the fluid-conveying line (3).

IPC Classes  ?

• B08B 9/027 - Cleaning the internal surfaces; Removal of blockages
• B08B 9/04 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes
• B08B 9/045 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes the cleaning devices being rotated while moved
• B08B 9/047 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes moved by externally powered mechanical linkage, e.g. pushed or drawn through the pipes the cleaning devices having motors for powering cleaning tools
• B08B 9/051 - Cleaning the internal surfaces; Removal of blockages using cleaning devices introduced into and moved along the pipes having self-contained propelling means for moving the cleaning devices along the pipes the cleaning devices having motors for powering cleaning tools
• B23D 1/08 - Planing or slotting machines cutting by relative movement of the tool and workpiece in a horizontal straight line only by movement of the tool
• B23D 21/14 - Machines or devices for shearing or cutting tubes cutting inside the tube
• B23D 21/00 - Machines or devices for shearing or cutting tubes

Abstract

The present invention describes a system and method for monitoring the behaviour and reproductive activity of animals in herds, capable of collecting information regarding animal behaviour by means of sensors, identifying and analyzing said information to find out about the routine behaviour of the animals, in terms of reproduction and motor activity. Above all, the present invention analyses the reproductive behaviour of the animals for the purpose of recognizing, for example, when a female animal is in the mating season and when successful copulation has occurred. The present invention is also capable of identifying a disease in animals which compromises motor activity. Specifically, the present invention comprises a wearable electronic device, an intravaginal device (2), a data collector (4) and a data processor (5), wherein the intravaginal device (2) is the device capable of identifying whether or not successful copulation has occurred, and the wearable electronic device is responsible for providing information on motor activity, localization, inter alia. The present invention pertains to the fields of electrical engineering, computing, veterinary medicine and telecommunications.

IPC Classes  ?

• A01K 21/00 - Devices for assisting or preventing mating
• A01K 29/00 - Other apparatus for animal husbandry

Abstract

The present invention relates to a nanometric-scale composition in the form of liposomes or nanoemulsions containing strands of interfering RNA (siRNA) capable of silencing the gene responsible for the expression of superexposed adhesion proteins in tumours, such as the enzyme ecto-5'-nucleotidase/CD73 (CD73) which is superexpressed in multiform glioblastoma and in other types of tumour. The binding of the liposomes or nanoemulsions to the siRNA promotes a site-directed release complex capable of being incorporated into various types of formulation, such as an intratumoral or intravenous injection or nasal administration.

IPC Classes  ?

• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/127 - Liposomes
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention describes a toroidal capillary electrophoresis system and a method for manufacturing a toroidal capillary electrophoresis system. Specifically, the present invention includes a toroidal cast microtube (10) that, in particular and on account of the toroidal shape thereof, improves performance of the electrophoresis method compared to other shapes in capillary electrophoresis systems already known in the prior art. The present invention pertains to the fields of chemistry, pharmacy and medicine.

IPC Classes  ?

• G01N 27/447 - Systems using electrophoresis

Abstract

The present invention describes a composition for gene therapy of the central nervous system comprising nonviral nanoscale (<1.0 micrometer) carriers complexed with at least one nucleic acid for purposes of gene therapy via nasal administration having as the main target the central nervous system, and also the processes for producing said carriers. The present invention pertains to the field of nanotechnology and consists of aqueous formulations that can be used in the pharmaceutical and medical sectors.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• C12N 15/11 - DNA or RNA fragments; Modified forms thereof
• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention describes an extractive oxidation process for removing contaminants from hydrocarbon streams using an ionic liquid combined with an organometallic ionic complex of iron(ll), which comprises a complex of iron(ll) cation with an ionophilic binder, catalyst of iron(ll) with ionophilic binder in its molecular structure, oxidation of which is performed with an oxidizing agent and is catalysed by the organometallic iron(ll) complex present in the phase of the ionic liquid. Besides maintaining its characteristics of selective solvent of oxidizing compounds, the ionic liquid combined with the organometallic complex of iron(ll) with catalytic ionophilic binder of the oxidizing agent, stimulating the reactive phenomenon taking place in the ionic liquid phase, with the effect that the iron remains stable in the ionic liquid phase, without being leached into the oily phase. This measure results in a considerable improvement in removal of the heteroatoms from the hydrocarbon medium.

IPC Classes  ?

• C10G 27/10 - Refining of hydrocarbon oils, in the absence of hydrogen, by oxidation with oxygen or compounds generating oxygen in the presence of metal-containing organic complexes, e.g. chelates, or cationic ion-exchange resins
• C10G 21/06 - Refining of hydrocarbon oils, in the absence of hydrogen, by extraction with selective solvents characterised by the solvent used
• C10G 53/04 - Treatment of hydrocarbon oils, in the absence of hydrogen, by two or more refining processes plural serial stages only including at least one extraction step
• C10G 53/14 - Treatment of hydrocarbon oils, in the absence of hydrogen, by two or more refining processes plural serial stages only including at least one oxidation step

Abstract

The present invention describes an extractive oxidation process for removing contaminants from hydrocarbon streams using an ionic liquid combined with an organometallic ionic complex of iron(ll), which comprises a complex of iron(ll) cation with an ionophilic binder, catalyst of iron(ll) with ionophilic binder in its molecular structure, oxidation of which is performed with an oxidizing agent and is catalysed by the organometallic iron(ll) complex present in the phase of the ionic liquid. Besides maintaining its characteristics of selective solvent of oxidizing compounds, the ionic liquid combined with the organometallic complex of iron(ll) with catalytic ionophilic binder of the oxidizing agent, stimulating the reactive phenomenon taking place in the ionic liquid phase, with the effect that the iron remains stable in the ionic liquid phase, without being leached into the oily phase. This measure results in a considerable improvement in removal of the heteroatoms from the hydrocarbon medium.

IPC Classes  ?

• C10G 27/10 - Refining of hydrocarbon oils, in the absence of hydrogen, by oxidation with oxygen or compounds generating oxygen in the presence of metal-containing organic complexes, e.g. chelates, or cationic ion-exchange resins
• C10G 53/04 - Treatment of hydrocarbon oils, in the absence of hydrogen, by two or more refining processes plural serial stages only including at least one extraction step
• C10G 53/14 - Treatment of hydrocarbon oils, in the absence of hydrogen, by two or more refining processes plural serial stages only including at least one oxidation step
• C10G 21/06 - Refining of hydrocarbon oils, in the absence of hydrogen, by extraction with selective solvents characterised by the solvent used

Abstract

Polymeric compositions may include one or more adjunct polymers selected from a group of an ionomer and a polar polymer; and an intelligent additive, wherein when exposed to the external stimuli, the intelligent additive triggers a color change in the polymeric composition. Polymer compositions may include a nonpolar matrix polymer; one or more adjuncts selected from the group of an ionomer, a polar polymer, a metal salt, or combinations thereof. Polymer compositions may also include an intelligent additive, wherein when exposed to the external stimuli, the intelligent additive triggers a color change in the polymeric composition, wherein after at least 17 hours of exposure to the external stimuli, the polymer composition exhibits a ΔE of at least 8 or more, maintaining the ΔE of at least 8 or more for at least 5 days after the exposure to external stimulus is ceased.

IPC Classes  ?

• C08K 9/10 - Encapsulated ingredients
• C08K 9/06 - Ingredients treated with organic substances with silicon-containing compounds
• C08K 5/00 - Use of organic ingredients
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• C08L 23/08 - Copolymers of ethene
• C08K 3/36 - Silica
• C08K 5/29 - Compounds containing carbon-to-nitrogen double bonds
• C08K 5/42 - Sulfonic acids; Derivatives thereof
• C08L 23/06 - Polyethene
• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators

Abstract

Polymeric compositions may include one or more adjunct polymers selected from a group of an ionomer and a polar polymer; and an intelligent additive, wherein when exposed to the external stimuli, the intelligent additive triggers a color change in the polymeric composition. Polymer compositions may include a nonpolar matrix polymer; one or more adjuncts selected from the group of an ionomer, a polar polymer, a metal salt, or combinations thereof. Polymer compositions may also include an intelligent additive, wherein when exposed to the external stimuli, the intelligent additive triggers a color change in the polymeric composition, wherein after at least 17 hours of exposure to the external stimuli, the polymer composition exhibits a ΔE of at least 8 or more, maintaining the ΔE of at least 8 or more for at least 5 days after the exposure to external stimulus is ceased.

IPC Classes  ?

• C08K 5/00 - Use of organic ingredients
• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
• C08K 9/06 - Ingredients treated with organic substances with silicon-containing compounds
• C08K 9/10 - Encapsulated ingredients
• C08L 23/06 - Polyethene
• C08L 23/08 - Copolymers of ethene
• C08L 23/12 - Polypropene
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Abstract

The present invention describes a pressure reducing system with energy re-use. More specifically, the present invention describes a prime mover (1) which is associated with a line of industrial fluids and is capable of causing a pressure drop in the line and recovering the energy released during the pressure drop. The present invention belongs to the field of mechanical engineering, more specifically to the field concerning the study of hydraulic, steam and gas turbines.

IPC Classes  ?

• F01K 27/00 - Plants for converting heat or fluid energy into mechanical energy, not otherwise provided for
• F01D 1/34 - Non-positive-displacement machines or engines, e.g. steam turbines characterised by non-bladed rotor, e.g. with drilled holes
• F01D 1/36 - Non-positive-displacement machines or engines, e.g. steam turbines characterised by non-bladed rotor, e.g. with drilled holes using fluid friction
• F01D 1/00 - Non-positive-displacement machines or engines, e.g. steam turbines
• F16L 55/02 - Energy absorbers; Noise absorbers
• G05D 16/00 - Control of fluid pressure

Abstract

The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.

IPC Classes  ?

• A61K 31/055 - Phenols the aromatic ring being substituted by halogen
• C07C 69/63 - Halogen-containing esters of saturated acids
• C07C 39/42 - Halogenated derivatives containing six-membered aromatic rings and other rings
• C07C 69/16 - Acetic acid esters of dihydroxylic compounds
• C07C 39/373 - Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings

Abstract

The present invention relates to a method for the selective control of populations of hematophagic arthropods, replacing or supplementing the use of pyrethroid insecticides by the use of tyrosine metabolism enzyme inhibitors, more specifically by the use of 4-hydroxyphenylpyruvate dioxygenase inhibitors, in particular those belonging to the class of substituted pyridyl phenyl ketones, their isomers and salts, or a combination of two or more of these compounds.

IPC Classes  ?

• C07C 317/14 - Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
• C07C 205/45 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly-bound oxygen atom, not being part of a —CHO group
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61P 33/00 - Antiparasitic agents

Abstract

The present invention relates to active and intelligent additives having hybrid characteristics, that are compatible with polymers, are thermally and mechanically stable, are capable of releasing electrons and/or photons in the presence of chemical compounds, specifically amino compounds, amide compounds, oxygen reducing compounds, water or vapors thereof. The active and intelligent additives incorporate themselves into polymer matrices allowing the obtainment of active and intelligent polymeric articles. These active and intelligent polymeric articles may act as inhibitors of growth of microorganisms and fungi, as well as indicators of the presence of gasses, either in the atmosphere or caused by the decomposition of foodstuffs, for example.

IPC Classes  ?

• C08K 9/10 - Encapsulated ingredients
• A01N 25/10 - Macromolecular compounds
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• C08J 5/18 - Manufacture of films or sheets
• C08K 9/06 - Ingredients treated with organic substances with silicon-containing compounds
• C08K 3/10 - Metal compounds
• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds
• C08K 5/092 - Polycarboxylic acids
• C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
• C08K 3/16 - Halogen-containing compounds
• C08K 5/00 - Use of organic ingredients
• A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom
• A01N 59/02 - Sulfur; Selenium; Tellurium; Compounds thereof
• A01N 59/20 - Copper
• C08L 23/02 - Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment

Abstract

The present invention describes a metallocene catalyst based on a transition metal of group 4 or 5 of the periodic table, supported on a hybrid catalytic support provided with aliphatic organic groups, and a process for supporting metallocene on the hybrid catalytic support. The supported metallocene catalyst provides an ethylene polymer with broad or bimodal molecular weight distribution, in the presence of only one metallocene complex on the support.

IPC Classes  ?

• C08F 4/02 - Carriers therefor
• C08F 4/6592 - Component covered by group containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring
• C08F 4/76 - Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from metals not provided for in group selected from refractory metals selected from titanium, zirconium, hafnium, vanadium, niobium, or tantalum
• C08F 210/16 - Copolymers of ethene with alpha-alkenes, e.g. EP rubbers
• C08F 4/659 - Component covered by group containing a transition metal-carbon bond
• C08F 10/00 - Homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
• C08F 110/02 - Ethene
• C08F 210/14 - Monomers containing five or more carbon atoms

Abstract

The present invention describes a metallocene catalyst based on a transition metal of group 4 or 5 of the periodic table, supported on a hybrid catalytic support provided with aliphatic organic groups, and a process for supporting metallocene on the hybrid catalytic support. The supported metallocene catalyst provides an ethylene polymer with broad or bimodal molecular weight distribution, in the presence of only one metallocene complex on the support.

IPC Classes  ?

• C08F 4/02 - Carriers therefor
• C08F 4/6592 - Component covered by group containing a transition metal-carbon bond containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring
• C08F 110/02 - Ethene
• C08F 210/16 - Copolymers of ethene with alpha-alkenes, e.g. EP rubbers
• C08F 4/76 - Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from metals not provided for in group selected from refractory metals selected from titanium, zirconium, hafnium, vanadium, niobium, or tantalum
• C08F 4/659 - Component covered by group containing a transition metal-carbon bond

Abstract

The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.

IPC Classes  ?

• A61K 31/055 - Phenols the aromatic ring being substituted by halogen
• C07C 39/42 - Halogenated derivatives containing six-membered aromatic rings and other rings
• C07C 69/63 - Halogen-containing esters of saturated acids

Abstract

The present invention proposes a recombinant strain of a pathogenic microorganism, comprised of an expression vector of an antigen derived from a parasite or disease vector, and a double vaccine comprising such a recombinant strain. In particular, the present invention consists of a double vaccine comprising a strain modified from Babesia bovis expressing glutathione S-transferase from ticks. The present invention is in the fields of biotechnology, veterinary medicine, and human medicine.

IPC Classes  ?

• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• C12N 1/36 - Adaptation or attenuation of cells
• C12N 9/10 - Transferases (2.)
• C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/018 - Babesia antigens, e.g. Theileria antigens

Abstract

The present invention describes molecules with a hybrid nucleus based on tetrahydroacridine and tianeptine nuclei separated by methyl spacer chains via a coupling reaction, a pharmaceutical composition comprising these molecules, a method for synthesising these molecules, and the uses thereof. The present invention belongs to the fields of medical chemistry, pharmacology and medicine.

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 281/12 - Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
• A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
• A61K 31/473 - Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.

IPC Classes  ?

• A61K 31/025 - Halogenated hydrocarbons carbocyclic
• A61K 31/03 - Halogenated hydrocarbons carbocyclic aromatic
• A61K 31/035 - Halogenated hydrocarbons having aliphatic unsaturation
• C07C 22/02 - Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
• C07C 25/13 - Monocyclic aromatic halogenated hydrocarbons containing fluorine

Abstract

The present invention describes the use of platelets in a method for evaluating in vitro a chemical and/or biological substance, a method for detecting and/or detecting in vitro a chemical and/or biological substance, and a kit for detecting and/or tracking in vitro a chemical and/or biological substance. More specifically, the platelets are arranged in a single layer. The present invention pertains to the fields of pharmacy, medicine and chemistry.

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
• G01N 33/15 - Medicinal preparations
• G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
• C12N 5/078 - Cells from blood or from the immune system

Abstract

The present invention describes cosmetic nanotechnology, comprising polymeric nanoparticles containing oil and UV filter, photoprotective compositions comprising polymeric nanoparticles described herein, methods of prevention of diseases of the skin, and processes for the preparation of the polymeric nanoparticles described herein.

IPC Classes  ?

• A61K 8/40 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
• A61K 8/11 - Encapsulated compositions
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/85 - Polyesters
• A61K 8/92 - Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/84 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds

Abstract

An article of manufacture includes a first graphene layer, a second graphene layer over the first graphene layer, the second graphene layer oriented at a first interlayer twist angle with respect to the first graphene layer and bonded by interlayer covalent bonds to the first graphene layer, and a third graphene layer over the second graphene layer, the third graphene layer oriented at a second interlayer twist angle with respect to the second graphene layer and bonded by interlayer covalent bonds to the second graphene layer. A multi-layer graphene article includes at least three graphene layers, each graphene layer being oriented at an interlayer twist angle with respect to an adjacent graphene layer and bonded by interlayer covalent bonds to the adjacent graphene layer.

IPC Classes  ?

• B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
• B32B 18/00 - Layered products essentially comprising ceramics, e.g. refractory products
• B32B 38/10 - Removing layers, or parts of layers, mechanically or chemically
• H01B 1/04 - Conductors or conductive bodies characterised by the conductive materials; Selection of materials as conductors mainly consisting of carbon-silicon compounds, carbon, or silicon

Abstract

Polymeric blends of polystyrene (PS) and polylactic acid (PLA) are described, in the preparation of which a compatibilizing agent was added, preferably a PS-PLA block copolymer. Such compatibilizing agents act controlling phase separation of the blending compounds, and preventing excessive growth of polystyrene domains scattered in the PLA matrix; and this results in blends with good mechanical and thermal resistance.

IPC Classes  ?

• C08L 25/06 - Polystyrene
• B41J 2/01 - Ink jet
• B41J 2/435 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by selective application of radiation to a printing material or impression-transfer material
• C09D 11/00 - Inks
• C08L 35/02 - Homopolymers or copolymers of esters
• C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• G09F 23/08 - Advertising on or in specific articles, e.g. ashtrays, letter-boxes the advertising matter being combined with articles for restaurants, shops, or offices with tableware
• C08L 51/04 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to rubbers
• B29B 9/12 - Making granules characterised by structure or composition
• B29K 25/00 - Use of polymers of vinyl-aromatic compounds as moulding material

Abstract

The present utility model describes an isoelastic femoral stem made of polymer for hip prostheses. The novelty is a differentiated femoral stem design made of polyether ether ketone (PEEK), a commercially available biomaterial which has very similar properties to those of human bone and withstands a fatigue test which simulates stress conditions to which a stem must be mechanically subjected in order to be approved for use. The stem can also be made of polymers having less mechanical strength than PEEK, as shown by tests carried out with nylon polymer (TECAST-L).

IPC Classes  ?

• A61L 27/00 - Materials for prostheses or for coating prostheses
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/30 - Inorganic materials
• A61L 27/32 - Phosphorus-containing materials, e.g. apatite
• A61F 2/30 - Joints
• A61F 2/32 - Joints for the hip
• A61F 2/38 - Joints for elbows or knees
• A61F 2/36 - Femoral heads
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces
• A61F 5/02 - Orthopaedic corsets
• A61B 17/76 - Devices for the head of the femur fixed by screws
• G01N 3/04 - Chucks
• G01N 3/56 - Investigating resistance to wear or abrasion

Abstract

The present invention relates to the control of infestation of pests by inhibiting or reducing the expression of genes of the family of chitin synthase. The invention further provides methods and compositions for controlling pests by feeding them with one or more double-strand RNA molecules provides by the present invention. The invention further describes a method of obtaining transgenic plants that express double-strand RNA molecules. The present invention is preferably used for cotton-plants.

IPC Classes  ?

• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A01N 43/54 - 1,3-Diazines; Hydrogenated 1,3-diazines

Abstract

The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.

IPC Classes  ?

• A61K 31/055 - Phenols the aromatic ring being substituted by halogen
• C07C 39/42 - Halogenated derivatives containing six-membered aromatic rings and other rings
• C07C 69/63 - Halogen-containing esters of saturated acids
• C07C 69/16 - Acetic acid esters of dihydroxylic compounds
• C07C 39/373 - Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings

Abstract

The present invention falls into the context of green chemistry and generically relates to a fertilizing and phytoprotective formulation and, in particular embodiment, to a film forming formulation that induces resistance to plants. The respective formulation, when applied to plants and/or fruits, results in the formation of a film on the surface of the material, which has a characteristic of photoprotection against UV-B and UV-C radiations, resistance kept in water, even after high hygroscopicity, greater stability at high ambient temperatures, formation of desired porosity and surface homogeneity.

IPC Classes  ?

• A01N 61/00 - Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
• A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
• A01N 63/02 - Substances produced by, or obtained from, microorganisms or animals
• C05G 3/02 - Mixtures of one or more fertilisers with materials not having a specifically fertilising activity with pesticides
• A01N 61/02 - Mineral oils; Tar oils; Tar; Distillates, extracts or conversion products thereof
• C05D 3/00 - Calcareous fertilisers
• C05D 9/02 - Other inorganic fertilisers containing trace elements
• C05F 1/00 - Fertilisers made from animal corpses, or parts thereof

Abstract

The present invention aims to provide a pharmaceutical composition for the treatment of alopecia, said composition comprising polymeric nanoparticles, preferably nanocapsules, containing finasteride, additives and a pharmaceutically acceptable carrier, as well as the use of the nanoparticles for preparing said composition for treating alopecia. The invention further includes an appropriate finasteride nanocapsule preparation process suitable for a composition for topical application for treating alopecia.

IPC Classes  ?

• A61K 8/63 - Steroids; Derivatives thereof
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61Q 7/00 - Preparations for affecting hair growth
• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 9/06 - Ointments; Bases therefor
• A61K 9/51 - Nanocapsules
• A61K 8/04 - Dispersions; Emulsions
• A61K 8/06 - Emulsions
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/37 - Esters of carboxylic acids
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/85 - Polyesters
• A61K 9/08 - Solutions
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to a pharmaceutical composition for topical application for the treatment of alopecia, said composition comprising polymeric nanoparticles, preferably nanocapsules containing two active ingredients, finasteride and minoxidil, additives and a pharmaceutically acceptable carrier. The invention further includes a process for the preparation of polymeric nanoparticles, preferably nanocapsules of finasteride and minoxidil, a composition suitable for topical application for the treatment of alopecia, as well as the use of said nanocapsules for the preparation of a pharmaceutical composition.

IPC Classes  ?

• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 9/51 - Nanocapsules
• A61K 31/473 - Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 9/08 - Solutions
• A61K 9/06 - Ointments; Bases therefor
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/58 - Organic coatings containing solid synthetic polymers
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Abstract

The present invention relates to the process of production of olefins by means of the dehydration of light alcohols using ionic liquids as an acidic medium. Furthermore, the present invention relates to the use of such olefins, for example, for the production of polymers and ethylene glycol.

IPC Classes  ?

• C07C 1/24 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by elimination of water
• C07C 29/04 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by addition of hydroxy groups to unsaturated carbon-to-carbon bonds, e.g. with the aid of H2O2 by hydration of carbon-to-carbon double bonds
• C07C 6/04 - Metathesis reactions at an unsaturated carbon-to-carbon bond at a carbon-to-carbon double bond

Abstract

The present invention describes benzylthiazolidinone derivatives and pharmaceutical compositions comprising the same; these compounds have shown activity in schizophrenia animal models, with the advantage of not causing the typical adverse effects of antipsychotic drugs, since they exhibited lower incidence of catatonia and weaker effects on motor coordination, when compared with other antipsychotic drugs, such as haloperidol and clozapine, and no central nervous system depression effect; the molecules showed an effect in models of apomorphine-induced climbing, ketamine-induced hyperlocomotion and in prepulse startle response inhibition. FPY-3 did not exhibit any toxic effects after 14 days of treatment, and is potentially useful for the treatment of schizophrenia.

IPC Classes  ?

• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61P 25/18 - Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

The present invention consists in an attractant diffuser for the coffee borer beetle, a coffee pest, in the form of an oily carrier, or aqueous wax paste, for slowly releasing volatile compounds, especially alcohols and coffee aroma, optionally associated with other active principles of interest in agriculture.

IPC Classes  ?

• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
• A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
• A01N 25/10 - Macromolecular compounds
• A01P 19/00 - Pest attractants

Abstract

The invention describes polymeric blends of polystyrene (PS) and polylactic acid (PLA) to which a compatibilising agent is added, preferably a PS-PLA block copolymer. The compatibilising agents have the effect of controlling phase separation between the blend components, preventing excessive growth of the polystyrene domains dispersed in the PLA matrix, leading to the production of blends having satisfactory thermal and mechanical resistance.

IPC Classes  ?

• C08L 63/00 - Compositions of epoxy resins; Compositions of derivatives of epoxy resins
• C08L 35/02 - Homopolymers or copolymers of esters
• C08L 25/06 - Polystyrene
• C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
• C09D 7/12 - Other additives
• C09D 5/02 - Emulsion paints
• C09D 11/00 - Inks
• B41J 2/01 - Ink jet
• B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
• B65D 85/86 - Containers, packaging elements or packages, specially adapted for particular articles or materials for electrical components
• B65H 75/14 - Kinds or types of circular or polygonal cross-section with two end flanges
• B65D 39/04 - Cup-shaped plugs or like hollow flanged members
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• A47G 21/00 - Table-ware
• B41J 2/435 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by selective application of radiation to a printing material or impression-transfer material
• G09F 23/08 - Advertising on or in specific articles, e.g. ashtrays, letter-boxes the advertising matter being combined with articles for restaurants, shops, or offices with tableware

Abstract

The present invention relates to a friction butt-welding machine for tubular elements, using the rotation of a disk which has a width similar to that of the wall of the tubular element and is placed between the ends of the two tubular elements to be welded. The machine comprises two systems for fastening the machine onto the tubular elements, which systems are actuated by hydraulic cylinders that extend along the axis of the tubular elements in order to apply pressure to each of the tubular elements, and a system of hydraulic cylinders which are also arranged along the axis of the tubular elements in order to apply a welding and compression force to the tubular elements. Besides the fastening systems, the equipment comprises a system for rotating the disk in order to cause friction between the disk and the tubular elements and carry out welding. This system comprises motors, a power transmission system and a ring for fastening the friction disk. The set values of the welding and compression force, rotation, welding and compression time, wearing of the tubular elements and ring, are automatically controlled from the outside by a servo-controlled system formed by commercially available devices, on the basis of data obtained from the load transducer and movement and motor torque transducers.

IPC Classes  ?

• B23K 20/12 - Non-electric welding by applying impact or other pressure, with or without the application of heat, e.g. cladding or plating the heat being generated by friction; Friction welding
• B23K 11/02 - Pressure butt welding

Abstract

The present invention relates to a process for producing polymeric structures that have activated surfaces. The process proved to be simple, quick, with high production capacity and low operating costs. The process occurs by depositing a polymer solution, which is assisted by a high electric field, on a conductive liquid surface to produce particles and/or filaments that have an activated surface. More particularly, the process of the present invention has the ability to produce particles and/or filaments that have chemically activated surfaces, in a single process.

IPC Classes  ?

• D01D 7/00 - Collecting the newly-spun products
• D01D 5/00 - Formation of filaments, threads, or the like
• B29B 9/06 - Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
• B29B 9/12 - Making granules characterised by structure or composition
• D01F 1/10 - Other agents for modifying properties
• D01F 6/16 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of unsaturated carboxylic acids or unsaturated organic esters, e.g. polyacrylic esters, polyvinyl acetate
• D01F 6/22 - Monocomponent man-made filaments or the like of synthetic polymers; Manufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of cyclic compounds with one carbon-to-carbon double bond in the side chain from polystyrene

Abstract

The present invention describes a method for completely extracting the alkaloid fraction (montanine) of Rhodophiala bifida (Herb.) Traub from bulbs of Rhodophiala bifida. The present invention further describes a method for treating inflammation using pharmaceutical compositions containing the alkaloid fraction of Rhodophiala bifida as the active ingredient. The present invention therefore comprises an extraction method that is faster than other extraction methods described in the literature for the alkaloid fraction of Rhodophiala bifida, dispensing with numerous changes of solvent in order to strain the plant, and the use thereof as an anti-inflammatory. The present invention is further characterised by the development of an anti-inflammatory medicinal drug for treating and preventing diseases involving inflammation and/or the local increase in the number of fibroblasts as its etiopathogenesis, such as: rheumatoid arthritis, ulcerative colitis, sepsis, acute pulmonary disease, inflammatory infections, in particular inflammatory and fibrosing diseases related to the lungs and kidneys, osteoporosis, Castleman disease, psoriatic arthritis, juvenile chronic arthritis and other non-specific inflammatory joint diseases.

IPC Classes  ?

• C07D 491/056 - Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.

IPC Classes  ?

• C07C 69/16 - Acetic acid esters of dihydroxylic compounds
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to fluorine substituted CBD compounds, compositions thereof and uses thereof for the preparation of medicaments.

IPC Classes  ?

• C07C 69/16 - Acetic acid esters of dihydroxylic compounds
• A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• A61P 35/00 - Antineoplastic agents
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The application relates to a process for producing a fertilizing phytoprotective composition comprising producing distilled wood vinegar extract (pyroligneous acid, preferably produced by distillation under reduced pressure) mixed with chitosan (preferably with a minimum degree of deacetylation of 97%) and a mineral solution (containing one or more of silicon, boron, molybdenum, manganese, zinc, calcium and copper), for producing the fertilizing composition that is also claimed. The application also defines applying the formulation to plants and parts thereof (fruit).

IPC Classes  ?

• C05F 17/00 - Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation
• C05F 15/00 - Mixtures of fertilisers covered by more than one of main groups ; Fertilisers from mixtures of starting materials, all the starting materials being covered by this subclass but not by the same main group
• A01N 61/02 - Mineral oils; Tar oils; Tar; Distillates, extracts or conversion products thereof
• A01N 55/08 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
• A01N 55/10 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing silicon

Abstract

The present invention relates to the control of pest infestation by inhibiting or reducing the expression of genes of the laccase family. The invention further provides pest control methods and compositions by feeding one or more double-stranded RNA molecules according to the present invention. The invention further provides a method for obtaining transgenic plants that express double-stranded RNA molecules. The present invention is preferably used for cotton plants.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/53 - Oxidoreductases (1)
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy

Abstract

The present invention relates to a metallocene catalyst containing a transition metal from group 4 or 5 of the periodic table, which is supported by hybrid catalytic supporting means with aliphatic organic groups. A process for supporting metallocene on said hybrid catalytic supporting means with aliphatic organic groups is also described. The main advantage of the supported metallocene catalyst of the present invention is that an ethylene polymer with broad or bimodal molar mass distribution is produced by using only one type of metallocene complex on the supporting means. As a result, the resin produced can be processed in an improved manner, which consequently potentially decreases processing costs.

IPC Classes  ?

• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 37/04 - Mixing
• C08F 10/00 - Homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
• C08F 210/16 - Copolymers of ethene with alpha-alkenes, e.g. EP rubbers

Abstract

The present invention aims at providing a pharmaceutical composition for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, that contain finasteride, pharmaceutically acceptable additives and carriers, and also relates to the use of the nanoparticles for preparing the composition for the treatment of alopecia. The invention further includes a method for preparing finasteride nanocapsules suitable for a composition for topical application for the treatment of alopecia.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61K 9/10 - Dispersions; Emulsions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

The present invention relates to a pharmaceutical composition of topical application for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, containing two active principles, finasteride and minoxidil, and pharmaceutically acceptable additives and carriers. The invention further includes a method for preparing polymeric finasteride and minoxidil nanoparticles, preferably nanocapsules, suitable for a composition of topical application for the treatment of alopecia, as well as the use of said nanocapsules for preparing a pharmaceutical composition.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• A61K 9/10 - Dispersions; Emulsions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia

Abstract

The present invention aims at providing a pharmaceutical composition for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, that contain finasteride, pharmaceutically acceptable additives and carriers, and also relates to the use of the nanoparticles for preparing the composition for the treatment of alopecia. The invention further includes a method for preparing finasteride nanocapsules suitable for a composition for topical application for the treatment of alopecia.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/10 - Dispersions; Emulsions
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to a pharmaceutical composition of topical application for the treatment of alopecia, the composition comprising polymeric nanoparticles, preferably nanocapsules, containing two active principles, finasteride and minoxidil, and pharmaceutically acceptable additives and carriers. The invention further includes a method for preparing polymeric finasteride and minoxidil nanoparticles, preferably nanocapsules, suitable for a composition of topical application for the treatment of alopecia, as well as the use of said nanocapsules for preparing a pharmaceutical composition.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/10 - Dispersions; Emulsions
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention relates to the use of means for reflecting, refracting or emitting light and means for controlling the direction in which the light is emitted, refracted or reflected, that are arranged to display images that compensate for the visual impairments of the users thereof, in particular the use of two panels, one for emitting or reflecting light and the other for controlling the direction in which the light is emitted. The combined arrangement of these two panels enables the visual impairments of the user to be compensated for. The technology may be used by manufacturers of LCD panels and applied to television screens, video monitors in computers, notebooks, netbooks, tablets, digital watches, calculators, electronic games consoles, e-readers, cell phones and wireless telephones and digital displays in electrical and electronic devices in general.

IPC Classes  ?

• G02B 27/22 - Other optical systems; Other optical apparatus for producing stereoscopic or other three-dimensional effects

Abstract

The present invention relates to active and intelligent additives having hybrid characteristics, that are compatible with polymers, are thermally and mechanically stable, are capable of releasing electrons and/or photons in the presence of chemical compounds, specifically amino compounds, amide compounds, oxygen reducing compounds, water or vapors thereof. The active and intelligent additives incorporate themselves into polymer matrices allowing the obtainment of active and intelligent polymeric articles. These active and intelligent polymeric articles may act as inhibitors of growth of microorganisms and fungi, as well as indicators of the presence of gasses, either in the atmosphere or caused by the decomposition of foodstuffs, for example.

IPC Classes  ?

• A01N 59/20 - Copper
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-anal
• A01N 59/02 - Sulfur; Selenium; Tellurium; Compounds thereof
• C08K 3/10 - Metal compounds
• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds
• C08K 5/092 - Polycarboxylic acids
• C08K 5/54 - Silicon-containing compounds
• C08K 3/00 - Use of inorganic substances as compounding ingredients
• C08K 5/00 - Use of organic ingredients
• C08L 23/12 - Polypropene
• C08K 9/10 - Encapsulated ingredients

Abstract

The present invention relates to a process for producing polymeric structures that have activated surfaces. The process proved to be simple, quick, with high production capacity and low operating costs. The process occurs by depositing a polymer solution, which is assisted by a high electric field, on a conductive liquid surface to produce particles and/or filaments that have an activated surface. More particularly, the process of the present invention has the ability to produce particles and/or filaments that have chemically activated surfaces, in a single process.

IPC Classes  ?

• D01D 5/11 - Flash-spinning
• B29B 9/06 - Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
• B29B 9/12 - Making granules characterised by structure or composition
• D01D 1/02 - Preparation of spinning solutions

Abstract

The present invention relates to the process of production of olefins by means of the dehydration of light alcohols using ionic liquids as an acidic medium. Furthermore, the present invention relates to the use of such olefins, for example, for the production of polymers and ethylene glycol.

IPC Classes  ?

• C07C 1/20 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms

Abstract

The present invention provides tianeptine derivatives, especially N-alkyl and N-alkenyl derivatives, use thereof, pharmaceutical compositions comprising same, and method for producing same. The tianeptine-derived compounds can potentially be used for treating tumours and/or psychiatric disorders.

IPC Classes  ?

• C07D 281/12 - Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
• A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
• C07D 281/02 - Seven-membered rings
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/24 - Antidepressants
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/08 - Antiepileptics; Anticonvulsants
• A61P 25/22 - Anxiolytics
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to the use of zeolites and mesoporous materials in the formulation of rubber compounds, thermoplastic rubber and plastics, paints, resins, adhesives and varnishes, as inorganic fillers applied to produce articles in various industrial fields, such as components of motor vehicle parts, mechanical parts, safety parts, sports materials, tyres, agricultural machines, packaging, machines used in the food and pharmaceutical industries, inter alia. Mechanical and chemical resistance are advantageously increased, and permeability to liquids and vapours is advantageously decreased, enhancing the rheological properties (viscosity) of the materials and improving the cohesiveness of the films, materials and parts produced therefrom.

IPC Classes  ?

• C01B 33/18 - Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
• C01B 39/02 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
• C01B 39/14 - Type A
• C01B 39/20 - Faujasite type, e.g. type X or Y
• C01B 39/24 - Type Y
• C01B 39/26 - Mordenite type
• C01B 39/28 - Phillipsite or harmotome type, e.g. type B
• C01B 39/30 - Erionite or offretite type, e.g. zeolite T
• C01B 39/32 - Type L
• C01B 39/38 - Type ZSM-5
• C01B 39/54 - Phosphates, e.g. APO or SAPO compounds
• B01J 29/04 - Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
• B01J 29/06 - Crystalline aluminosilicate zeolites; Isomorphous compounds thereof
• B01J 39/00 - Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
• C01F 1/00 - Methods of preparing compounds of the metals beryllium, magnesium, aluminium, calcium, strontium, barium, radium, thorium, or the rare earths, in general

Abstract

The present invention relates to a chemical method for decontaminating fruit-based beverages and processed foodstuffs contaminated with patulin, by reaction with chalcogen or amino acid compounds or derivatives thereof. Processes are disclosed for eliminating or reducing the patulin content by adding to the product organo-chalcogenides that can react with the mycotoxin, forming a new, non-toxic substance.

IPC Classes  ?

• A23L 1/015 - Removal of unwanted matter, e.g. deodorisation, detoxification (A23L 1/211 takes precedence);;
• A23L 3/3463 - Organic compounds; Microorganisms; Enzymes
• A23L 3/3535 - Organic compounds containing sulfur
• A23L 3/3526 - Organic compounds containing nitrogen
• A23L 3/3508 - Organic compounds containing oxygen containing carboxyl groups

Abstract

The present invention refers to the synthesis of precatalysts and the use of such precatalysts in ethylene oligomerization reactions for the selective production of alpha-olefins. More specifically, it refers to the preparation and use of coordination compounds containing polydentate ligands comprising Group 6 and 10 transition metal compounds, in particular chromium (III) and nickel (II). Such catalytic precursors present high catalytic activity and selectivity for the production of alpha-olefins.

IPC Classes  ?

• C07F 15/04 - Nickel compounds
• C07C 2/02 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
• C07C 2/32 - Catalytic processes with hydrides or organic compounds as complexes, e.g. acetyl-acetonates
• C07F 11/00 - Compounds containing elements of Groups 6 or 16 of the Periodic System

Abstract

The present invention relates to intelligent additives with hybrid characteristics, which are compatible with polymers, thermally and mechanically stable, and capable of releasing electrons and/or photons in the presence of chemical compounds, particularly amine, amide, or oxido-reductive compounds, water or vapours thereof. Said intelligent additives are incorporated into polymeric matrices allowing intelligent polymeric articles to be produced. Said intelligent polymeric articles may be used as microorganism and fungal growth inhibitors, and also as gas indicators, for gases in the atmosphere or, for example, produced by food decomposition.

IPC Classes  ?

• C08L 23/04 - Homopolymers or copolymers of ethene
• C08L 23/12 - Polypropene
• C08K 3/10 - Metal compounds
• C08K 3/30 - Sulfur-, selenium-, or tellurium-containing compounds
• C08K 5/092 - Polycarboxylic acids
• C08K 5/54 - Silicon-containing compounds

Abstract

The present invention relates to chemical sensors with hybrid characteristics, which are thermo-mechanically stable and able to respond to changes in the environment, particularly in the presence of amine and/or amide and/or oxide-reducing compounds, and/or vapor thereof by color change, as well as its incorporation into sensitive polymeric composition.

IPC Classes  ?

• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators

Abstract

The present invention describes cosmetic nanotechnology, comprising polymeric nanoparticles containing oil and UV filter, photoprotective compositions comprising polymeric nanoparticles described herein, methods of prevention of diseases of the skin, and processes for the preparation of the polymeric nanoparticles described herein.

IPC Classes  ?

• A61K 8/92 - Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products
• A61K 8/40 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
• A61K 8/11 - Encapsulated compositions
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/85 - Polyesters
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61K 8/84 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds

Abstract

The present invention belongs to the field of plant extracts with activity on the central nervous system. Specifically, the plant extract of the present invention is an extract obtained from Hypericum polyanthemum and comprising the compound uliginosin B and/or compounds from the class of benzopyrans such as. The present invention also relates to a pharmaceutical composition comprising such an extract which has pharmacological action in psychiatric disorders, such as mood disorders, specifically, anti-depressant activity. Such as HP1 (6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran), HP2 (7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethyl-benzopyran) and HP3 (5-hydroxy-6-isobutyryl-7-methoxy-2,2-dimethyl-benzopyran)).

IPC Classes  ?

• A61K 36/38 - Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
• A61P 25/24 - Antidepressants
• A61K 133/00 - Containing or obtained from flowers or blossoms

Abstract

The present invention describes cosmetic nanotechnology, comprising polymeric nanoparticles containing oil and UV filter, photoprotective compositions comprising polymeric nanoparticles described herein, methods of prevention of diseases of the skin, and processes for the preparation of the polymeric nanoparticles described herein.

IPC Classes  ?

• A61K 8/92 - Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products
• A61K 8/11 - Encapsulated compositions
• A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

The present invention relates to a nanoparticulated anaesthetic composition for topical use in which at least one local anaesthetic agent is encapsulated in polymeric nanoparticles. The present invention also relates to the use of such polymeric nanoparticles comprising at least one local anaesthetic agent in the preparation of an anaesthetic composition for topical application to the skin or mucosa.

IPC Classes  ?

• A61K 9/50 - Microcapsules
• A61K 31/16 - Amides, e.g. hydroxamic acids

Abstract

The present invention relates to chemical sensors, with hybrid characteristics, which are thermomechanically stable and able to respond to p H changes in the presence of amine, amide and oxide- reducing compounds, through color change, as well as its incorporation into polymeric matrixes and the use thereof.

IPC Classes  ?

• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroups; Apparatus specially adapted for such methods using chemical indicators
• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper

Abstract

The present invention relates to a nanoparticulated anaesthetic composition for topical use in which at least one local anaesthetic agent is encapsulated in polymeric nanoparticles. The present invention also relates to the use of such polymeric nanoparticles comprising at least one local anaesthetic agent in the preparation of an anaesthetic composition for topical application to the skin or mucosa.

IPC Classes  ?

• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 47/30 - Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates

Abstract

The present invention provides an apparatus for digitalization of dental structures which is precise and efficient, generating unequivocal three- dimensional data. The apparatus of the invention comprises at least one articulated arm and at least one probe, said articulated arm and probe providing dental structure scanning directly by mouth contact, being a comfortable device for the patient. The method of the invention provides an advantageous way by which dental structure moulds can be produced, since it generates very accurate three-dimensional data of the dental.

IPC Classes  ?

• A61C 19/04 - Measuring instruments specially adapted for dentistry

Abstract

The present invention related to a process of preparation of nanocomposite polyolefins based on organophilic clay and polyolefin as shown in Figure 1. More specifically, the present invention relates to a process to prepare nanocomposites, which provides more efficient exfoliation of organophilic clay particles in the polymeric matrix and, hence a product has significantly improved mechanical thermal and barrier properties and good optical properties. The nanocomposite product obtained by means of the process herein described and claims, constitutes a second aspect of the present invention.

IPC Classes  ?

• C08K 9/04 - Ingredients treated with organic substances
• C08K 3/34 - Silicon-containing compounds