Abstract

The present invention relates to novel derivatives of linear polyglycerol conjugated to fatty acids, their preparation process by linear controlled accretion of the polymer chain and their use as surfactant agents in various fields of the art, including Q cosmetics, pharmaceuticals and food.

IPC Classes  ?

• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
• C08G 65/22 - Cyclic ethers having at least one atom other than carbon and hydrogen outside the ring

Abstract

The present invention relates to the technical field of pharmaceutical carriers or bases and pharmaceutical compositions. In particular, the invention relates to a water-based pharmaceutical carrier. Advantageously, the carrier of the present invention allows the formulation of those active ingredients for which there is a need for these latter actives to adhere to the oropharyngeal and esophageal mucosae, in particular those active ingredients insoluble in aqueous media, for which there is a need for these latter actives to adhere to the oropharyngeal and esophageal mucosae. The present invention further relates to a pharmaceutical composition comprising said pharmaceutical carrier, said composition being particularly suitable for oral use.

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 47/38 - CelluloseDerivatives thereof

Abstract

The present invention relates to microcapsules containing probiotic strains and a. process for their preparation that uses a polymer mixture capable of imparting to said microcapsides high resistance to agents potentially adverse to the viability of probiotics such as. for example, temperature, pH, gastric and small intestinal enzymes and bile salts.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/50 - Microcapsules
• A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics

Abstract

Disclosed herein are an imaging method and a related imaging system (100, 200). The imaging method comprises: - providing an array of light sources (S1', S2', Sk', S(k+1)', Sn'), each source (S1', S2', Sk', S(k+1)', 5 Sn') configured for the output of a light emission (W1, W2, Wk, W(k+1), Wn), - providing an imaging unit (2) including a focusing element (L0) and a detector (DT) configured for detecting the light emissions from the sources of the array (SRC') 10 through the focusing element (L0), - providing an object (OBJ) between the detector (DT) and the array of light sources (SRC'), - providing an imaging device (IL, FFL) between the array of light sources (SRC') and the object (OBJ), 15 - operating the array of light sources (SRC') by activating the light sources (S1', S2', Sk', S(k+1)', Sn') according to a sequential pattern, whereby a position of the activated light source (S1', S2', Sk', S(k+1)', Sn') in the array (SRC') with respect to the 20 object (OBJ) is varied with the activation of the light sources (S1', S2', Sk', S(k+1)', Sn') according to said sequential pattern, - imaging the array of light sources (SRC') through said imaging device (IL, FFL) while operating the array 25 of light sources (SRC'), - detecting the spatial location at which images (I1 - In) of points of said object (OBJ) form under the disparate positions of the activated light sources (S1', S2', Sk', S(k+1)', Sn') in the array (SRC'), through the 30 imaging device (IL, FFL), and through the focusing element (L0), on said detector (DT), and a shift (O1 - On) of each detected spatial location with respect to a reference spatial location (x), - 27 - - reconstructing an image of the object (OBJ) by aligning the images of points of said object (OBJ) formed under the disparate positions of the activated light sources (S1', S2', Sk', S(k+1)', Sn') in the array (SRC') by offsetting the shift of each detected spatial location 5 with respect to the reference spatial location (x).

IPC Classes  ?

• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 27/58 - Optics for apodization or superresolutionOptical synthetic aperture systems

Abstract

Disclosed herein is A method for detection of at least one binding event of specific binding pair-forming substances, comprising: - providing a layer (2) of a first specific binding 5 pair-forming substance on a substrate (3), said specific binding pair-forming substance having a density comprised between 102 and 104 per μm2 of said substrate (3) - providing an enclosure (4) of said layer (2) of a first specific binding pair-forming substance with a first 10 dielectric medium, the first dielectric medium comprising a first solution having a first pH value and a first ionic strength value, - rinsing the enclosure (4) for a first period of time with a second dielectric medium comprising a second 15 solution having a second pH value and a second ionic strength value, wherein at least said second pH value is different than said first pH value, - restoring said first dielectric medium having the first pH value and the first ionic strength value in said 20 enclosure (4) following said rinsing, - feeding a solution of a second specific binding pair-forming substance to the enclosure (4) of said layer (2) of a first specific binding pair-forming substance to cause an interaction between said first specific binding 25 pair-forming substance and second specific binding pair- forming substance following said restoring the first dielectric medium in said enclosure (4), and incubating the enclosure (4) for a second period of time, the interaction comprising a binding event when the first 30 specific binding pair-forming substance and the second specific binding pair-forming substance provide said specific binding pair, - detecting a shift (∆θ) in a parameter (θ) representative of a dielectric function of the layer (2) 35 - 50 - of a first specific binding pair-forming substance following said incubating the enclosure (4) for a second period of time, the shift being defined as a variation of the parameter (θ) representative of a dielectric function of the layer (2) of a first specific binding pair-forming 5 substance from a first value occurring when said enclosure (4) only includes said first dielectric medium following said restoring said first dielectric medium, and a second value occurring following incubating said enclosure (4) for the second period of time, 10 - comparing the shift (∆θ) with a threshold value, whereby when the shift exceeds the threshold value at least one binding event between said first specific binding pair- forming substance and second specific binding pair-forming substance has occurred.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to a method and a corresponding device for quickly and non-invasively estimating the state of anaemia in a subject, thanks to capturing and subsequently processing a digital image of the palpebral conjunctiva.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to novel Formyl Peptide Receptor subtype 2 (FPR2) agonist compounds and their use in the recovery of the inflammatory phenomena in which said receptor is involved, particularly in the context of the treatment of the autism spectrum disorder.

IPC Classes  ?

• C07D 223/12 - Nitrogen atoms not forming part of a nitro radical
• A61K 31/275 - NitrilesIsonitriles
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07C 275/30 - Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
• C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

Disclosed herein is a device (10; 20; 30; 40; 50; 60; 70; 80; 90; 100) for the plenoptic reconstruction of indirect images of an object (OBJ). Unlike prior art techniques, it is possible to overcome the problem of focusing the indirect image in the case of an object (OBJ) positioned outside a focusing plane without requiring new acquisitions of the image itself, thanks to the features of the plenoptic image acquisition device PC. Although the indirect image is visible only after the evaluation of the correlations, if such image is out of focus it is possible to perform a refocusing by using the data available in the plenoptic acquisition. Therefore, it becomes possible to reconstruct the indirect image of objects irrespective of their location, as well as of moving objects.

IPC Classes  ?

• H04N 23/95 - Computational photography systems, e.g. light-field imaging systems
• H04N 23/80 - Camera processing pipelinesComponents thereof
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 7/557 - Depth or shape recovery from multiple images from light fields, e.g. from plenoptic cameras
• H04N 23/957 - Light-field or plenoptic cameras or camera modules

Abstract

The present invention relates to the field of biotechnologies and in particular to a nucleotide sequence having promoter activity of the transcription in prokaryotic and eukaryotic cell systems.

IPC Classes  ?

• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The present invention relates to a device for identifying and monitoring possible environmental contamination by pathogenic and non-pathogenic microorganisms, e.g., viruses. The present invention further relates to a system comprising said device.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

A hyperspectral imaging device and method disclosed herein overcomes the technical problems associated with the prior art by replacing the intensity measurement performed by the single high-resolution 2D sensor of state-of-the-art methodologies, with the measurement of intensity (fluctuation) correlations retrieved by two high-resolution 2D sensors: one—the imaging/spatial sensor dedicated to polychromatic image acquisition, the other—the spectral sensor dedicated to pure spectral measurement. In the hyperspectral correlation imaging disclosed herein, the spectral information is encoded into the intensity correlation without requiring any spectral scanning. Even though multiple exposures (frames) are generally required to reconstruct light statistics and perform correlation measurements, the exposure times are several orders of magnitude shorter than those required in the scanning approach. In addition, no changes of the device are required during such multiple exposures, which simplifies the optics/optomechanics of the device and avoids further time consumption.

IPC Classes  ?

• G01J 3/28 - Investigating the spectrum
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details

Abstract

The present invention relates to a process for the production of irisin, comprising the following steps: providing an expression vector comprising a nucleotide sequence coding for said irisin; inserting said expression vector into at least one first bacterium of the Agrobacterium genus, thus obtaining a first bacterium of the Agrobacterium genus comprising said expression vector; treating at least one plant material with said first bacterium comprising said expression vector, thus obtaining a treated plant material; cultivating said treated plant material, so that said treated plant material expresses said irisin; and extracting said irisin. The present invention further relates to irisin included in liposomes, its use as a medicament and its administration routes, a synthetic gene comprising a sequence coding for irisin and additional elements.

IPC Classes  ?

• C07K 14/575 - Hormones
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• A61P 3/00 - Drugs for disorders of the metabolism

Abstract

The present invention relates to the technical field of the 3D printing, particularly the 3D printing in the sector of the preparation of solid pharmaceutical forms. Such pharmaceutical forms being solid pharmaceutical forms obtained by extrusion of a powder mixture comprising at least one active ingredient and at least one pharmaceutically acceptable excipient. Therefore, the invention relates to a 3D printing process for preparing a solid pharmaceutical form. The invention also relates to a solid pharmaceutical form obtainable by said process.

IPC Classes  ?

• A61J 3/06 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• A61K 9/20 - Pills, lozenges or tablets

Abstract

The present invention relates to novel derivatives of linear polyglycerol conjugated to fatty acids, their preparation process by linear controlled accretion of the polymer chain and their use as surfactant agents in various fields of the art, including cosmetics, pharmaceuticals and food.

IPC Classes  ?

• C08G 65/26 - Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
• C08G 65/323 - Polymers modified by chemical after-treatment with inorganic compounds containing halogens

Abstract

The present invention relates to the field of biotechnologies and in particular to the use of a nucleotide sequence having transcription promoter activity in prokaryotic and eukaryotic cell systems.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

A system for biological assay includes a first plate having a plurality of protrusions, a second plate configured for mating with said first plate, the second plate including a plurality of receptacles, each receptacle being configured to receive at least a portion of a corresponding one of said protrusions upon mating of the first plate with the second plate, wherein each protrusion includes a gate electrode configured for facing the respective receptacle upon mating of the first plate with the second plate, and wherein each receptacle further includes at least one source-drain channel operatively associated to a gate electrode carried by a respective protrusion upon mating of the first plate with the second plate.

IPC Classes  ?

• G01N 27/403 - Cells and electrode assemblies
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Goods & Services

Education, entertainment and sport services; Publishing, reporting, and writing of texts; Ticket reservation and booking services for education, entertainment and sports activities and events; Translation and interpretation.

Abstract

The present invention relates to a method and a corresponding device for quickly and non-invasively estimating the state of anaemia in a subject, thanks to capturing and subsequently processing a digital image of the palpebral conjunctiva.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present invention relates to novel Formyl Peptide Receptor subtype 2 (FPR2) agonist compounds and their use in the recovery of the inflammatory phenomena in which said receptor is involved, particularly in the context of the treatment of the autism spectrum disorder.

IPC Classes  ?

• C07D 295/185 - Radicals derived from carboxylic acids from aliphatic carboxylic acids
• C07D 211/38 - Halogen atoms or nitro radicals
• C07D 223/12 - Nitrogen atoms not forming part of a nitro radical
• C07D 209/44 - Iso-indolesHydrogenated iso-indoles
• C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
• C07D 471/04 - Ortho-condensed systems
• C07D 217/06 - Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ringAlkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
• C07D 215/08 - Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
• A61K 31/4035 - Isoindoles, e.g. phthalimide
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 31/4465 - Non-condensed piperidines, e.g. piperocaine only substituted in position 4
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/472 - Non-condensed isoquinolines, e.g. papaverine
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to a device for identifying and monitoring possible environmental contamination by pathogenic and non-pathogenic microorganisms, e.g., viruses. The present invention further relates to a system comprising said device.

IPC Classes  ?

• G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Prostate-Specific Membrane AntigenProstate-Specific Membrane Antigen (PSMA) ligands, for use as radiopharmaceutical precursors (cold kits). The formulation of the invention is designed to allow the radiopharmaceutical to be prepared instantaneously and in a single step by direct addition of radioactive isotopes, to be used both for diagnostic and therapeutic purposes.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61K 103/00 - Radioactive metals
• A61P 35/00 - Antineoplastic agents

Abstract

Disclosed herein are a hyperspectral imaging device (1, 100, 200, 300, 400; 500; 600; 700; 800) and method. The device and method for hyperspectral imaging disclosed herein overcomes the technical problems of the prior art by replacing the intensity measurement performed by the single high-resolution 2D sensor of state-of-the-art methodologies, with the measurement of intensity (fluctuation) correlations retrieved by two high- resolution 2D sensors: one - the imaging/spatial sensor (4, 204, 304, 404; 504; 604; 704; 804) - dedicated to polychromatic image acquisition, the other - the spectral sensor (5, 205, 305, 405; 505; 605; 705; 805) - dedicated to pure spectral measurement. In hyperspectral correlation imaging according to the invention, the spectral information is encoded into the intensity correlation without requiring any spectral scanning. Even though multiple exposures (frames) are generally required to reconstruct light statistics and perform correlation measurements, the exposure times are several orders of magnitude shorter than those required in the scanning approach; in addition, no changes of the device are required during such multiple exposures: this simplifies the optics/optomechanics of the device (1, 100, 200, 300, 400; 500; 600; 700; 800) and avoids further time consumption.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/14 - Generating the spectrumMonochromators using refracting elements, e.g. prism
• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• G01J 3/28 - Investigating the spectrum

Abstract

in vitroOnchocerca lupiin vitroOnchocerca lupiOnchocerca lupi infection.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A process and an apparatus for the plenoptic capture of photographic or cinematographic images of an object or a 3D scene (10) of interest are based on a correlated light emitting source and correlation measurement, along the line of “Correlation Plenoptic Imaging” (CPI). A first image sensor (Da) and a second image sensor (Db) detect images along a path of a first light beam (a) and a second light beam (b), respectively. A processing unit (100) of the intensities detected by the synchronized image sensors (Da, Db) is configured to retrieve the propagation direction of light by measuring spatio-temporal correlations between light intensities detected in the image planes of at least two arbitrary planes (P′, P″; D′b, D″a) chosen in the vicinity of the object or within the 3D scene (10).

IPC Classes  ?

• H04N 13/128 - Adjusting depth or disparity
• H04N 13/254 - Image signal generators using stereoscopic image cameras in combination with electromagnetic radiation sources for illuminating objects
• H04N 13/122 - Improving the 3D impression of stereoscopic images by modifying image signal contents, e.g. by filtering or adding monoscopic depth cues
• H04N 13/296 - Synchronisation thereofControl thereof
• H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
• H04N 5/225 - Television cameras
• G02B 21/06 - Means for illuminating specimen
• G02B 21/22 - Stereoscopic arrangements

Abstract

A system (1; 100; 200) for biological assay includes: - a first plate (2; 102; 202) comprising a plurality of protrusions (4; 104; 204), - a second plate (3) configured for mating with said first plate (2; 102; 202), the second plate comprising a plurality of receptacles, each receptacle being configured to receive at least a portion of a corresponding one of said protrusions upon mating of the first plate with the second plate, wherein each protrusion comprises a gate electrode (7; 106; 207) configured for facing the respective receptacle (5) upon mating of the first plate with the second plate. Each receptacle (5) further includes at least one source-drain channel operatively associated to a gate electrode (7; 106; 207) carried by a respective protrusion (4; 104; 204) upon mating of the first plate (2; 102; 202) with the second plate (3).

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to the field of biotechnologies and in particular to the use of a nucleotide sequence having transcription promoter activity in prokaryotic and eukaryotic cell systems.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/81 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

Described herein is a field effect transistor sensor including: a substrate, a source electrode, a drain electrode, a gate electrode functionalized with a layer of biological recognition elements, a source-drain channel and a semiconductor layer. The layer of biological recognition elements of the gate electrode is patterned into a plurality of uncoupled domains.

IPC Classes  ?

• H01L 29/41 - Electrodes characterised by their shape, relative sizes or dispositions
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

The present invention relates to a composition comprising at least one inhibitor of the enzymatic complex conjugating ubiquitin Ubc13/Uev1a and at least one anti-hypertensive agent inhibiting the renin-angiotensin-aldosterone system and/or a hypoglycemic agent. Medical uses and pharmaceutical compositions comprising this composition also fall within the scope of the present invention. In particular, this composition can be used for the treatment or prevention of the renal fibrotic damage, in particular in patients suffering from diabetes.

IPC Classes  ?

• A61K 31/345 - Nitrofurans
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
• A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

A process and device for the plenoptic capture of photographic or cinematographic images are described, both based on the correlation measure or “Correlation Plenoptic Imaging” (CPI), comprising the steps of splitting a primary light beam (6) coming from at least one light source in at least two distinct light beams (7, 8), directing said distinct light beams towards two image capturing sensors to capture images, so that the first light beam is directed towards at least one first capturing sensor to capture a spatial measure of a scene and the second light beam is directed towards a second capturing sensor to capture an angular measure of said scene, said angular measure being adapted to provide the propagation direction of the light beam coming from the scene, said spatial measure being adapted to provide the conventional two-dimensional capture of the image of the scene. The device further comprises a main focal lens (Lb) arranged along the optical path of the first light beam, said main focal lens (Lb) and second sensor (14) being arranged so that the length of the light's optical path between the light source (4) and the second sensor (14) is substantially equal to the length of the light's optical path between the light source (4) and said main focal lens (Lb).

IPC Classes  ?

• G06T 7/557 - Depth or shape recovery from multiple images from light fields, e.g. from plenoptic cameras
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

A field effect transistor sensor includes: a source-drain channel, a semiconductor layer on said source-drain channel, a first gate electrode arranged above said semiconductor layer, a first well enclosing said source-drain channel, said semiconductor layer and said first gate electrode, the first well being configured to be filled, in use, with a first liquid, particularly a gating electrolyte, a second gate electrode arranged above the first gate electrode and exposed to an interior of the first well. Also disclosed is an array device including an array of field effect transistor sensors according to the above.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

ɑɑ bb ɑbɑɑ bb baa a ) chosen in the vicinity of the object or within the 3D scene (10).

IPC Classes  ?

• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• H04N 5/225 - Television cameras

Abstract

The invention relates to a device for the rapid diagnosis of poisoning from enzymatic toxic substances such as cyanide. The device of the invention is a biomedical, portable, easy to use and low-cost device for the rapid diagnosis of poisoning and intoxication of a subject, which can be performed directly at the point-of-care. More specifically, the device measures oxygen saturation in the retina venous vessels of human subjects. The invention also relates to the method for conducting such diagnoses.

IPC Classes  ?

• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes

Abstract

A method of functionalization of a gate electrode of a field-effect transistor sensor includes forming a layer of biological recognition elements on a surface of said gate electrode, wherein said layer of biological recognition elements includes a self-assembled structure of one or more specific-binding-pair-forming substances (anti-hIg, anti-IgG, anti-IgM). The layer of biological recognition elements is treated with a solution containing a blocking agent to fill vacancies and prevent nonspecific binding in the self-assembled structure. One or more specific-binding-pair-forming substances immobilized in said layer of biological recognition elements are packed at a density of 0.1×104 μm−2 and 10×104 μm−2, preferably between 1×104 μm−2 and 2×104 μm−2.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

Disclosed herein is a field effect transistor (BS, BS') sensor including: - a source-drain channel (2) - a semiconductor layer (4) on said source-drain channel (2) - a first gate electrode (14, 14') arranged above said semiconductor layer (4), - a first well (6) enclosing said source-drain channel (2), said semiconductor layer (4) and said first gate electrode (14, 14'), the first well (6) being configured to be filled, in use, with a first liquid (8), particularly a gating electrolyte, - a second gate electrode (24, 24') arranged above the first gate electrode (14, 14') and exposed to the interior of the first well (6). Also disclosed is an array device (AD) including an array of field effect transistor sensors (BS) according to the above.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

A process and device for the plenoptic capture of photographic or cinematographic images are described, both based on the correlation measure or "Correlation Plenoptic Imaging" (CPI), comprising the steps of splitting a primary light beam (6) coming from at least one light source in at least two distinct light beams (7, 8), directing said distinct light beams towards two image capturing sensors to capture images, so that the first light beam is directed towards at least one first capturing sensor to capture a spatial measure of a scene and the second light beam is directed towards a second capturing sensor to capture an angular measure of said scene, said angular measure being adapted to provide the propagation direction of the light beam coming from the scene, said spatial measure being adapted to provide the conventional two-dimensional capture of the image of the scene. The device further comprises a main focal lens (Lb) arranged along the optical path of the first light beam, said main focal lens (Lb) and second sensor (14) being arranged so that the length of the light's optical path between the light source (4) and the second sensor (14) is substantially equal to the length of the light's optical path between the light source (4) and said main focal lens (Lb).

IPC Classes  ?

• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
• G06T 7/557 - Depth or shape recovery from multiple images from light fields, e.g. from plenoptic cameras

Abstract

The invention relates to a process for the pyrolytic treatment of micronizable materials, comprising the following steps: - low-temperature pyrolytic treatment of a flux of micronized material; - controlled reforming of the syngas against the micronized material by means of the application of energy coming from renewable or recovered sources.

IPC Classes  ?

• C10J 3/72 - Other features
• C10B 51/00 - Destructive distillation of solid carbonaceous materials by combined direct and indirect heating
• C10J 3/60 - Processes

Abstract

222, aiming at separating liquid methane, gaseous hydrogen, liquid carbon monoxide.

IPC Classes  ?

• B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/24 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by centrifugal force
• C12M 1/00 - Apparatus for enzymology or microbiology
• C10L 3/10 - Working-up natural gas or synthetic natural gas
• F25J 3/06 - Processes or apparatus for separating the constituents of gaseous mixtures involving the use of liquefaction or solidification by partial condensation
• F25J 1/00 - Processes or apparatus for liquefying or solidifying gases or gaseous mixtures

Abstract

Described herein is a field effect transistor (BS) sensor including: - a substrate (1), - a source electrode (2, 4) 5 - a drain electrode (3, 4) - a gate electrode (5, 6) functionalized with a layer (9) of biological recognition elements, - a source-drain channel (4) - a semiconductor layer (7). 10 The layer of biological recognition elements (9) of the gate electrode (5, 6; G1, G2, G3; G2, G3, G4, G5, G6, G7, G8) is patterned into a plurality of uncoupled domains (9D).

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

Described herein is a method of functionalization of a gate electrode (6) of a field-effect transistor sensor (BS) comprising the steps of: - forming a layer of biological recognition elements on a surface (6F) of said gate electrode (6), wherein said layer of biological recognition elements (9) includes a self-assembled structure (SAM) of one or more specific-binding-pair- forming substances (anti-hlg, anti-IgG, anti-IgM), - treating the layer of biological recognition elements (SAM) with a solution containing a blocking agent to fill vacancies and prevent nonspecific binding in the self-assembled structure (SAM), wherein said one or more specific -binding-pair-forming substances immobilized in said layer of biological recognition elements (9) are packed at a density comprised 0.1 x 104 μm-2 and 10 x 104 μm-2, preferably between 1 x 104 μm-2 and 2 x 104 μm-2. Also disclosed herein is a FET biosensor functionalized according to the above method.

IPC Classes  ?

• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Pharmaceutical formulation comprising 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine and at least one buffering agent in a aqueous vehicle, wherein the formulation has a pH value comprised between 4.0 and 5.5, preferably between 4.5 and 5.0, more preferably about 5, and corresponding uses in diagnostic imaging methods.

IPC Classes  ?

• A61K 51/04 - Organic compounds

Abstract

The invention relates to a new class of compounds of formula (I) targeting COX-1. The invention also relates to the use of some of such compounds as a tool to investigate the structure and function of the enzyme, in the treatment targeting COX-1 or detection of COX-1 in relating disorders or diseases such as cancer and neuroinflammation, in particular in neurological (e.g. autism spectrum disorders) and neurodegenerative diseases (e.g. Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), traumatic brain injury (TBI), HIV dementia and prion diseases), and in gynecological tumour (e.g. ovarian cancer), neck and head tumor, and haematological tumours (e.g. multiple myeloma) and in the detection of COX-1 in "in vitro" (cells and tissues) and in "in vivo".

IPC Classes  ?

• C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07H 13/04 - Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
• A61K 31/42 - Oxazoles
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to a method and to an apparatus for extracting virgin olive oil from olives and other oil-fruits allowing to reduce the production time by guarantee the product qualitative level.

IPC Classes  ?

• A23L 1/025 - Physical treatment, e.g. with wave energy, irradiation, electrical means, magnetic fields (cooking A23L 1/01; preserving A23L 3/00, A23B)
• C11B 1/06 - Production of fats or fatty oils from raw materials by pressing

Abstract

The invention relates to a method for manufacturing a proton conductive membrane. The method of the invention comprises the following steps: a) depositing on said surface of said substrate a layer of polymer material by hot wire chemical vapour deposition starting from a gaseous mixture comprising: at least two monomers having the following formula (I): RFyOzA02X wherein: A is P or S; X is F or C1; 1 ≤ y ≤ 25; 0 ≤ z ≤ 6; R is a C1-C25, saturated or unsaturated, linear or branched, alkyl chain optionally comprising a cyclic or aromatic group, and a polymerisation initiator, and b) hydrolysis of the layer of polymer obtained in step a). The invention is usable in the field of storage and restitution of energy, in particular.

IPC Classes  ?

• H01M 8/10 - Fuel cells with solid electrolytes
• C08J 5/22 - Films, membranes or diaphragms

Abstract

The present invention lies in the field of the treating and transforming of olives or other oleaginous fruits in processes for extracting virgin oils. In particular, it refers to a method and an apparatus for thermal treatment of olives or other oleaginous fruits, for crushing in controlled or modified atmosphere and for kneading in controlled or modified atmosphere, allowing to reduce the kneading times, improving the working capacity of the line, concomitantly preserving the quality of the product.

IPC Classes  ?

• A23N 4/08 - Machines for stoning fruit or removing seed-containing sections from fruit, characterised by their stoning or removing device for stoning fruit for dates, olives or the like oblong fruits
• A23N 7/08 - Peeling vegetables or fruit for peeling fruit and removing seed-containing sections
• C11B 1/00 - Production of fats or fatty oils from raw materials

Abstract

The invention relates to a new class of compounds able to inhibit with high affinity and selectivity the 5-HT7 receptor. The invention also relates to the utilization of such compounds as medicaments useful in the treatment and prevention of 5-HT7 receptor relating disorders of the central nervous system. The invention also relates to the isotopically labeled compounds for use in vivo diagnosis or imaging of a 5-HT7 condition.

IPC Classes  ?

• C07D 239/26 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 241/12 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 295/084 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 25/06 - Antimigraine agents

Abstract

The invention relates to a new class of compounds with high affinity and selectivity towards P-glycoprotein. The invention also relates to the utilization of such compounds in the in vivo diagnosis of neurodegenerative diseases and as medicaments for use in the prevention and treatment of neurodegenerative disease involving P-glycoprotein.

IPC Classes  ?

• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/42 - Oxazoles
• A61K 31/426 - 1,3-Thiazoles