Abstract

The glucose-responsive transcription factor ChREBP (Carbohydrate Response Element Binding Protein) is a key mediator in the response to glucose in pancreatic β-cells, strongly regulating glycolytic and lipogenic pathways. Several protein regulators interact with ChREBP that are involved in its activation mechanism, including 14-3-3 protein. Small-molecules are provided, which are useful as stabilizers for ChREBP 14-3-3 complexes, which were found highly useful for medical treatments, i.a. in type 1 and type 2 diabetes.

IPC Classes  ?

• C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
• C07F 9/40 - Esters thereof
• C07F 9/38 - Phosphonic acids (R—P(:O)(OH)2); Thiophosphonic acids

Goods & Services

Building chemicals and auxiliaries, in particular Construction chemical preparations and aids being mixtures or additives for the following goods: Hydraulic binding agents, Solvents, Dispersing agents, Water retention agents, retarding agents, Accelerating agents and Source components [chemicals from the source]. Building materials, not of metal; Hydraulic binding agents being non-metallic building materials and mixtures thereof with one or several additives, including rock grains and/or pozzolanic materials; Cement, lime, Mortars, concretes, Plaster and gravel; Ready-mixed plaster, Ready mixed mortar, Plaster mixtures, Mortar mix, Mixtures for flooring. Construction. Engineering services, Including in particular Construction engineering services.

Abstract

The invention pertains to a method for immortalising cells that are used for the harvesting of extracellular vesicles (EV). EV, derived for example from mesenchymal stromal cells, but also from other cell types, are known to induce beneficial effects during treatment of for example autoimmune disorders. However, the generation of secreting mesenchymal stromal cells is often dependent on donor material or the fact that isolated cells have a limited life span and limited number of passages of cell culture. The present invention provides a method of immortalising such secreting cells, the immortalised cells and medical applications thereof.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The invention concerns methods for treating mood disorders such as depressive disorder or episodes, or other mood disorders with current depressive episodes, by administration of a leptin receptor agonist, such as metreleptin. The invention further shows amelioration of depressive disorder or episode and related conditions in patients suffering from depression as a primary disorder, or a depressive disorder or episode as a secondary disorder and/or comorbidity. The invention also concerns methods for treating a depressive episode, or a depressive disorder.

IPC Classes  ?

• A61K 38/22 - Hormones
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The present invention relates to a method for making a micrometer-sized agglomerate powder for use as active anode material, a spray dried micrometer-sized agglomerate powder comprising nanometer-sized silicon-containing particles and a polymeric binder, a coating composition comprising the micrometer-sized agglomerate powder, a method for making an anode or an energy storage device comprising the step of applying the coating composition onto an anode substrate, and an anode or energy storage device comprising the micrometer-sized agglomerate powder.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 4/02 - Electrodes composed of, or comprising, active material

Abstract

The present disclosure relates to recombinant interferon alpha 2 (IFNa2) mutants and variants as well as fragments thereof, nucleic acids encoding them, pharmaceutical compositions containing them, and methods of use thereof.

IPC Classes  ?

• C07K 14/56 - IFN-alpha
• C12N 15/63 - Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
• A61K 47/10 - Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• A61P 31/12 - Antivirals

Abstract

The invention concerns methods for treating unwanted body weight loss, and/or medically undesired body weight loss, or eating disorders (such as anorexia nervosa), by administration of a leptin receptor agonist, such as metreleptin. The invention also relates to methods for increasing body weight in a subject in need of the treatment.

IPC Classes  ?

• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training
• A61K 38/22 - Hormones

Abstract

4444, PD1, PD-L1 and PD-L2 in the EV or EV-preparation. The method of the invention allows for an evaluation of the immunomodulatory efficacy of said EV preparations without the need of performing laborious functional in vivo or in vitro assays including mixed lymphocyte reaction assays. In three additional aspects of the invention, alternative methods for producing therapeutically active EVs or EV-preparations are provided. Further provided are therapeutically active EVs or EV preparations produced by the methods of the invention and their use in medicine, for example in the manufacturing of immunomodulatory medicaments.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The invention relates to a device (1) for generating STIR images, comprising: - input means (IT1) for T1-weighted images (BT1) of an area to be examined; - input means (IT2) for T2-weighted images (BT2) of the area to be examined; - at least one machine-learning-based network (MLN); - input means (IT) for training data (TD) for the machine-learning-based network; - output means (O) for providing generated STIR images of the area to be examined; wherein: the device (1) is designed for the T1-weighted images (BT1) and the T2-weighted images (BT2) of the area to be examined to be fed to the machine-learning-based network (MLN) configured by means of the training data (TD); the machine-learning-based network (MLN) configured by means of the training data (TD) is designed for STIR images of the area to be examined to be generated from the fed T1-weighted images (BT1) and the T2-weighted images (BT2); the output means (O) are designed to provide the STIR images of the area to be examined that were produced by means of the machine-learning-based network (MLN). The invention also relates to a method for generating STIR images by means of a device, and to the use of the device/the method.

IPC Classes  ?

• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The invention pertains to a method for immortalising cells that are used for the harvesting of extracellular vesicles (EV). EV, derived for example from mesenchymal stromal cells, but also from other cell types, are known to induce beneficial effects during treatment of for example autoimmune disorders. However, the generation of secreting mesenchymal stromal cells is often dependent on donor material or the fact that isolated cells have a limited life span and limited number of passages of cell culture. The present invention provides a method of immortalising such secreting cells, the immortalised cells and medical applications thereof.

IPC Classes  ?

• A61K 35/12 - Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
• C12N 5/0775 - Mesenchymal stem cells; Adipose-tissue derived stem cells

Abstract

The invention relates to an aerogel concrete mixture containing a photocatalyst, a photocatalytically active high-performance aerogel concrete obtainable therefrom and a method for producing same.

IPC Classes  ?

• C04B 28/04 - Portland cements
• C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
• C04B 18/02 - Agglomerated materials
• C04B 18/14 - Waste materials; Refuse from metallurgical processes
• C04B 22/06 - Oxides; Hydroxides
• C04B 18/08 - Flue dust
• B01J 21/06 - Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
• B01J 23/745 - Iron
• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01D 53/86 - Catalytic processes

Abstract

The invention relates to the use of a compound according to formulae (1), (2) and/or (3) of the pharmaceutically acceptable salts or esters thereof for the preparation of a medicament for the prophylactic and/or therapeutic treatment of an infection with coronaviruses, in particular SARS-CoV-2.

IPC Classes  ?

• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/191 - Acyclic acids having two or more hydroxy groups, e.g. gluconic acid
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to a process for absorbing carbon dioxide from an air stream, wherein the air stream is contacted with a carbon dioxide absorbent, the carbon dioxide absorbent comprising at least: a) water; b) polyethylene glycols or polyols having a molecular weight of less than or equal to 1000 g/mol; and c) carbon dioxide absorbing agents, the carbon dioxide absorbing agent being selected from the group of inorganic carbonates, amines, polyethylene glycolamines, diaminopolyethylene glycols, carboxylic acid derivatives of the polyethylene glycolamines, polyethylene imines, amine-containing sugar derivatives, amino acids, or mixtures of at least two of these components. The present invention further relates to a carbon dioxide absorbent for absorbing carbon dioxide from an air stream.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/96 - Regeneration, reactivation or recycling of reactants

Abstract

The invention shows a device for producing nanoparticles, the device having a pulsed laser with a scanning device for guiding the beam of the laser over a target that is fixed in a flow-through chamber. The flow-through chamber is reversibly connected to a supply line for carrier fluid, so that the flow-through chamber is exchangeable e.g. for a further flow-through chamber having a different target and/or a different dimensioning.

IPC Classes  ?

• B22F 9/04 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from solid material, e.g. by crushing, grinding or milling
• B22F 1/00 - Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
• B23K 26/0622 - Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure

Abstract

The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

IPC Classes  ?

• C07K 11/02 - Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins
• A61K 38/00 - Medicinal preparations containing peptides
• C07K 1/10 - General processes for the preparation of peptides using coupling agents
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Goods & Services

Apparatus for computer programs and software, irrespective of the recording or broadcast medium, including software recorded on a magnetic carrier or downloadable from an external computer network; Apparatus for recording data, Magnetic data carriers, compact discs, DVDs and other digital recording media, Data processing equipment, All the aforesaid goods included in class 9. Advertising, marketing and promotional consultancy, advisory and assistance services; Assistance in business conduct and management; Business administration; office functions and administrative services, All the aforesaid services in particular relating to the setting up of businesses, businesses set up by universities and the registration thereof. Financial advice and consultancy services, Financial information and financial consultancy, and providing of financial data; All the aforesaid services in particular relating to the setting up of businesses, businesses set up by universities and the registration thereof. Consultation services relating to business education; Educational instruction; Training; Entertainment services; Sporting activities; Cultural activities; arranging and conducting, in relsation to the following fields: Teaching, Correspondence courses, Correspondence courses, Seminars, Computer education training services, All the aforesaid services in particular relating to the setting up of businesses, businesses set up by universities and the registration thereof. Legal services; In particular relating to the setting up of businesses, businesses set up by universities and the registration thereof.

Abstract

The present invention relates to recombinant interferon alpha 2 (IFNa2) mutants and variants as well as fragments thereof, nucleic acids encoding them, pharmaceutical compositions containing them, and methods of use thereof.

IPC Classes  ?

• C07K 14/56 - IFN-alpha
• A61P 31/12 - Antivirals
• C12N 15/21 - Alpha-interferons
• C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Abstract

The present invention relates to recombinant interferon alpha 2 (IFNa2) mutants and variants as well as fragments thereof, nucleic acids encoding them, pharmaceutical compositions containing them, and methods of use thereof.

IPC Classes  ?

• C07K 14/56 - IFN-alpha
• A61P 31/12 - Antivirals

Abstract

A peptide derivative selected from a list of peptide derivatives with a sequence derived from human serum albumin fragment EPI-X4 is provided, which binds to CXCR4 with about 1000-fold stronger efficiency than EPI-X4. The peptide derivatives comprise length variants as well as modifications by length variants, D-amino acids, coupling of fatty acids, cholesterol or polymers, acetyl substitutions of amino groups, aminations of carboxyl groups. Further provided are pharmaceutical compositions of the peptide derivative.

IPC Classes  ?

• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The invention relates to a method for producing a nitrogen-containing silicon-carbon composite, wherein one or several gas streams that contain the starting compounds of the silicon, the carbon and the nitrogen are introduced into a hot-tube reactor and the starting compounds are allowed to react at a temperature in the range of ≥ 800°C to ≤ 1300°C, and the starting compounds are reacted to a nitrogen-containing silicon-carbon composite.

IPC Classes  ?

• C01B 33/029 - Preparation by decomposition or reduction of gaseous or vaporised silicon compounds other than silica or silica-containing material by decomposition of monosilane
• C04B 35/584 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides based on silicon nitride
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates

Abstract

The invention relates to an aerogel concrete mixture containing a photocatalyst, a photocatalytically active high-performance aerogel concrete obtainable therefrom and a method for producing same.

IPC Classes  ?

• B01D 53/86 - Catalytic processes
• B01J 21/06 - Silicon, titanium, zirconium or hafnium; Oxides or hydroxides thereof
• C04B 14/30 - Oxides other than silica
• C04B 28/04 - Portland cements

Abstract

The invention relates to the use of iron oxide particles in wastewater to eliminate heavy metals and/or cyanides. According to the invention, colloidal iron oxide particles suspended in wastewater are agglomerated by the addition of alkaline-earth metal salt solutions and/or flocculants at variable concentration, and subsequently the heavy metals and/or cyanides and/or polyfluorinated alkyl compounds are adsorbed onto or react with the iron oxide particles.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• B01J 20/02 - Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
• B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
• B01J 20/32 - Impregnating or coating
• C02F 103/10 - Nature of the water, waste water, sewage or sludge to be treated from quarries or from mining activities
• C02F 103/16 - Nature of the water, waste water, sewage or sludge to be treated from metallurgical processes, i.e. from the production, refining or treatment of metals, e.g. galvanic wastes
• C02F 101/14 - Fluorine or fluorine-containing compounds
• C02F 101/18 - Cyanides
• C02F 101/20 - Heavy metals or heavy metal compounds

Abstract

The invention presents an apparatus for producing nanoparticles, which comprises a pulsed laser with a scanning device in order to guide the beam of the laser over a target that is secured in a flow chamber. The flow chamber is intended to be detachably connected to a supply line for carrier fluid, so that the flow chamber can be exchanged, for example for a further flow chamber that has a different target and/or different dimensions.

IPC Classes  ?

• B22F 1/00 - Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
• B22F 9/02 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes
• B22F 9/04 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using physical processes starting from solid material, e.g. by crushing, grinding or milling

Abstract

The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

IPC Classes  ?

• C07K 11/02 - Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins
• C07K 1/10 - General processes for the preparation of peptides using coupling agents
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The invention relates to a wireless access device (14) for a wireless transmission of data provided in the form of an optical signal, comprising a transmission device (36) which comprises a converter unit (40) for a fiber-to-wireless conversion and an antenna unit (42) which is connected downstream of the converter unit (40) and which has at least one leaky-wave antenna (44) that is formed with at least one waveguide and an antenna element (46) formed on the waveguide. The invention additionally relates to a corresponding network (10) with a fiber-optic data transmission, at least one server (12), and at least one wireless access device (14), and to the use of the wireless access device (14) for transmitting data.

IPC Classes  ?

• H04B 10/2575 - Radio-over-fibre, e.g. radio frequency signal modulated onto an optical carrier
• H04B 7/04 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
• H04B 7/06 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The invention relates to an implant to be introduced into a living being, comprising at least one chamber (2), the chamber wall (2a) of which is semi-permeable at least in some regions, preferably the entire chamber wall (2a) of which is semi-permeable, wherein living cells are introduced or at least can be introduced into the chamber (2). The implant comprises at least one anchor element (3) expandable from a collapsed state and connected to the at least one chamber (2), and the implant is fastenable by means of the at least one anchor element (3) to an inner wall of a blood vessel (1) of the living being, in particular of an arterial blood vessel (1) and preferably of the aorta.

IPC Classes  ?

• A61F 2/02 - Prostheses implantable into the body

Abstract

e.g.e.g.e.g.e.g., amyloidopathies), and/or in the treatment of brain or spinal cord damage associated with acute trauma, stroke, and the like, and/or in the treatment of lysosomal storage diseases, and/or in the treatment of lipofuscin-related disorders, and in various viral infections.

IPC Classes  ?

• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
• C07F 9/40 - Esters thereof

Abstract

The invention relates to the use of a sphingosine-1-phosphate signal transduction modulator for producing a medicament for treating a disease or disorder, which is associated with sphingosine-1-phosphate and its receptors, wherein the disease or disorder is selected from the group comprising diseases or disorders of the bone tissue, of the fatty tissue and/or of the glucose metabolism, and to corresponding medicaments.

IPC Classes  ?

• A61P 3/06 - Antihyperlipidemics
• A61K 31/417 - Imidazole-alkylamines, e.g. histamine, phentolamine
• A61K 31/4415 - Pyridoxine, i.e.vitamin B6
• A61K 31/4439 - Non-condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 3/08 - Drugs for disorders of the metabolism for glucose homeostasis
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

The invention relates to a method for reducing the hydraulic conductivity of sedimentary or rock strata, in which colloidal particles suspended in a liquid are introduced into the sedimentary or rock strata with the aid of a boring device, and agglomerate in the pores; and to the use of such particles to increase the output and/or yield in oil production or to prevent the spread of contamination after accidents and/or disasters.

IPC Classes  ?

• C09K 8/50 - Compositions for plastering borehole walls, i.e. compositions for temporary consolidation of borehole walls
• C01G 49/02 - Oxides; Hydroxides
• C09K 8/504 - Compositions based on water or polar solvents
• C09K 8/516 - Compositions for plastering borehole walls, i.e. compositions for temporary consolidation of borehole walls characterised by their form or by the form of their components, e.g. encapsulated material
• C09K 8/584 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of specific surfactants
• C09K 8/588 - Compositions for enhanced recovery methods for obtaining hydrocarbons, i.e. for improving the mobility of the oil, e.g. displacing fluids characterised by the use of specific polymers
• C09K 8/594 - Compositions used in combination with injected gas

Abstract

A surgical simulator having at least two holding elements on a support surface, wherein a bore for receiving a bearing pin is present laterally on the holding elements at least one location, and at least one bow is arranged coaxially with respect to the bearing pin which extends on a circular or rectangular line about the support surface, wherein, by a coaxial movement of the bow about the circular or rectangular line, a work field of variable size can be adjusted, and, by the movement of the bow as frame element on the holding elements, the support surface can be spanned in an arc shape, and the use of such a surgical simulator for medical and veterinary training purposes.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 23/30 - Anatomical models

Abstract

The invention relates to a device (1) for diagnostics, particularly for quantitative diagnostics, of a sample (2) which comprises at least one type of SERS-active particles, each type having a specific Raman band (16, 20, 21, 22), by means of surface-enhanced Raman scattering (SERS), wherein the device (1) has a light source (3) for substantially monochromatic light, an optical probe (4) for illuminating the sample (2) to be examined with light from the light source (3) and for collecting scattered light from the sample (2), and a Raman photo detector (5, 5a, 5b, 5c, 5d) as well as a reference photo detector (11) for detecting the light collected by the probe (4) and scattered by the sample (2), wherein an optical filter element (8) for separating elastic scattered light from inelastic scattered light within the specific Raman band (16, 20, 21, 22) is arranged in the beam path of the light scattered by the sample (2), wherein the inelastic scattered light is conducted and the elastic scattered light is blocked by the optical filter element (8), and an additional filter and reflection element (9, 9a, 9b, 9c, 9d, 9e) for separating a reference band (10) specific to a substrate of the sample from the specific Raman band (16, 20, 21, 22) of the SERS-active particles is arranged in the beam path behind the filter element (8) for separating elastic scattered light from inelastic scattered light, wherein the reference band is reflected and directed to the Raman photo detector (5, 5a, 5b, 5c, 5d) and the reference band is allowed through and directed to the reference photo detector (11). The invention also relates to a corresponding method.

IPC Classes  ?

• G01N 21/65 - Raman scattering
• G01J 3/44 - Raman spectrometry; Scattering spectrometry
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 21/47 - Scattering, i.e. diffuse reflection

Abstract

The invention relates to displacement bodies for steel reinforced concrete floors comprising an aerogel concrete mixture, to methods for the production thereof, corresponding steel reinforced concrete floors and the use of high performance aerogel concrete as displacement bodies in steel reinforced concrete floors.

IPC Classes  ?

• C04B 28/02 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
• E04B 5/00 - Floors; Floor construction with regard to insulation; Connections specially adapted therefor

Abstract

The invention relates to a wood-concrete composite floor which comprises a high-performance aerogel concrete, to methods for producing these wood-concrete composite floors and to the use of high-performance aerogel concrete in wood-concrete composite floors.

IPC Classes  ?

• E04B 5/12 - Load-carrying floor structures formed substantially of prefabricated units with wooden beams
• C04B 28/04 - Portland cements
• E04B 5/23 - Floor structures partly formed in situ with stiffening ribs or other beam-like formations wholly or partly prefabricated
• E04G 23/02 - Repairing, e.g. filling cracks; Restoring; Altering; Enlarging

Abstract

The present invention pertains to an improved chemical synthesis method for Ahp- cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/54 - Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Abstract

The present invention relates to a method for performing a bioleaching process of chalcopyrite comprising the steps of: providing a chalcopyrite containing material; providing microorganisms, the microorganisms oxidizing iron(ll) at a rate such that the redox potential does not rise above 550 mV relative to a Ag+/AgCI electrode; adding said microorganisms to the chalcopyrite containing material; allowing reaction at said redox potential to provide copper ions.

IPC Classes  ?

• C22B 3/18 - Extraction of metal compounds from ores or concentrates by wet processes with the aid of microorganisms or enzymes, e.g. bacteria or algae
• C22B 15/00 - Obtaining copper

Abstract

The present invention relates to a method allowing a particularly efficient ligand exchange of a detergent bilayer on the surface of metal nanoparticles for molecular functionalization and assembly, and corresponding functionalized nanoparticles and nanoparticle assemblies that can be prepared using this method, as illustrated in Figure 16, as well as their use, e.g., for piasmonic applications such as surface-enhanced Raman scattering (SERS). In particular, the invention provides corresponding methods for preparing a dimeric nanoparticle assembly, a core-satellite nanoparticle assembly, and a functionalized nanoparticle, respectively.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• G01N 21/65 - Raman scattering

Abstract

The invention relates to a thermoelectric element (10), comprising an n-type superlattice structure (3-1), which comprises alternating layers of a first material (M1) and of a second material (M2) different from the first material, wherein polar interfaces (I-n) having electron excess are formed between the alternating layers, and a p-type superlattice structure (3-2), which comprises alternating layers of the first material (M1) and of the second material (M2) different from the first material, wherein polar interfaces (I-p) having hole excess are formed between the alternating layers. The n-type superlattice structure (3-1) and the p-type superlattice structure (3-2) have a connection (4).

IPC Classes  ?

• H01L 35/22 - Selection of the material for the legs of the junction using inorganic compositions comprising compounds containing boron, carbon, oxygen, or nitrogen
• H01L 35/26 - Selection of the material for the legs of the junction using compositions changing continuously or discontinuously inside the material

Abstract

An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element (2) fastened thereto, by means of which the sealing body is able to be fastened in the heart, preferably in the atrium of the heart, wherein the sealing body comprises at least one cavity (6), which is also able to be filled with a fluid after implanting the sealing body and preferably not able to be emptied independently, and wherein, furthermore preferably, the sealing body remains expanded with constant volume during the cardiac phases as a result of the filling, characterized in that a plurality of cavities (6) are disposed about a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, or a single cavity (6) surrounds a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, wherein the main body (1) is embodied as a tube which is able to be bent out of the linear extent thereof and into the lateral surface of which a multiplicity of cuts have been introduced.

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

The invention relates to the use of a field effect transistor in an open gate FET circuit, wherein the measurement sensitivity is increased in measurements of the smallest signals. This is achieved in that the field effect transistor is cooled such that the leakage currents within the transistor equal less than 10-15 A.

IPC Classes  ?

• H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
• G01Q 30/10 - Thermal environment

Abstract

The invention concerns a method for production of components comprising a Schottky diode by means of printing technology. The method involves a step of application and deposition of a semiconductor-nanoparticle dispersion on a first electrode, which is disposed on a substrate, the step of exposure to laser light of the deposited semiconductor-nanoparticle dispersion to form a mu-cone with a bottom and a tip, wherein the bottom of the mu-cone is joined to the first electrode, the step of embedding the thus-formed mu-cone in an electrically insulating polymer matrix, and the step of applying a second electrode, so that the tip of the mu-cone is joined to the second electrode.

IPC Classes  ?

• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 29/872 - Schottky diodes
• H01L 21/268 - Bombardment with wave or particle radiation with high-energy radiation using electromagnetic radiation, e.g. laser radiation
• H01L 29/66 - Types of semiconductor device
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Abstract

According to the invention, a heat assisted magnetic recording disk drive is provided which comprises a magnetic recording medium (1) with a heat sink layer (4), characterized in that the heat sink layer (4) comprises at least a material being defined by the general structure Mn+1AXn, wherein M is a transition metal, A is an A-group element, X is C or N or a mixture of C and N, and n is a positive integer, or a material defined by the general structure Mn+1AXn, wherein M is a transition metal, X is one or both of C and N, and n is a positive integer, or a mixture of the materials being defined by the general structure Mn+1AXn and the material defined by the general structure Mn+1Xn, wherein the crystal structure of the materials is hexagonal with repeated M-X-M (quasi 2D) atomic layers, the atomic layers are stacked along the (AA) and the (AA) is oriented substantially parallel to the surface normal of the heat sink layer. In this way, a heat assisted magnetic recording disk drive comprising a magnetic recording medium (1) with a heat sink layer (4) is provided, wherein the storage density of the magnetic recording medium (1) is increased.

IPC Classes  ?

• G11B 5/73 - Base layers

Abstract

A surgical simulator having at least two holding elements (19) on a support surface (17), wherein a bore (5) for receiving a bearing pin (6) is present laterally on the holding elements (19) at at least one location, and at least one bow (7) is arranged coaxially with respect to the bearing pin (6) which extends on a circular or rectangular line about the support surface (17), wherein, by a coaxial movement of the bow (7) about the circular or rectangular line, a work field (8) of variable size can be adjusted, and, by the movement of the bow (7) as frame element on the holding elements (19), the support surface (17) can be spanned in an arc shape, and the use of such a surgical simulator for medical and veterinary training purposes.

IPC Classes  ?

• G09B 23/28 - Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes for medicine
• G09B 23/30 - Anatomical models

Abstract

The invention relates to an anti-CEACAM1 antibody which has an antigen binding site with a sequence homology of at least 80 % to the sequence WINTYTGEPT (SEQ ID No. 21). The invention also relates to nucleic acids which code such an antibody. Furthermore, the invention relates to the therapeutic, preventative and in vitro use of the antibody.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

The invention relates to a system for the parallel videographic or photographic acquisition of images, in particular of samples in multiple sample wells (16) of a multi-well test plate, preferably of a microtiter plate, comprising at least one array of microscopes (2, 8) with mutually parallel optical axes, wherein each microscope comprises its own image-capturing chip (2) and its own objective lens (8), and wherein the system comprises at least one support plate (1), on the surface of which all the image-capturing chips (2) of all microscopes (2, 8) of an array are attached next to each other, forming together a line and row arrangement, an image data processing electronic unit (3) located laterally next to the array of image-capturing chips (2) and/or behind the array of image-capturing chips (2), and an array of objective lenses (8), in particular microscope objective lenses (8) with a corresponding line and row arrangement located in front of the image-capturing chips (2), when viewed in the direction of the optical axes (A).

IPC Classes  ?

• G02B 21/00 - Microscopes
• G02B 21/18 - Arrangements with more than one light-path, e.g. for comparing two specimens
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 21/08 - Condensers

Abstract

Described is an integrated vertical structure for infrared sensors, Peltier cooling, and thermoelectric generator applications consisting of a thermally insulating layer which is kept at a distance to a substrate by at least two spacers. In addition, the spacers have conductor structures which serve as thermoelectric elements. A method realizes manufacturing the integrated thermoelectric structure, a method realizes the operation of the integrated thermoelectric structure as a detector, a further method realizes the operation of the integrated thermoelectric structure as a thermoelectric generator, and a method realizes the operation of the integrated thermoelectric structure as a thermoelectric Peltier element.

IPC Classes  ?

• H01L 35/32 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the structure or configuration of the cell or thermocouple forming the device
• H01L 35/30 - SEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR - Details thereof operating with Peltier or Seebeck effect only characterised by the heat-exchanging means at the junction
• H01L 35/34 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The invention provides a method for optical clearing of biological samples utilizing a composition comprising a cinnamate ester. The invention further provides a kit suitable for performing said method and the use of said composition for optical clearing of biological samples.

IPC Classes  ?

• G01N 1/30 - Staining; Impregnating

Abstract

The method relates to a method, to a device and to the use of a device for the recovery of hydrocarbons from the vapor phase of a liquid gas mixture from at least one liquid gas tank using an adsorber, wherein the recovery takes place during degassing, wherein, in order to increase the adsorption capacity of adsorbents, use is made of a fluid in order to cool the adsorbents of the adsorber, the temperature of which is regulated at least in part by the evaporation of the liquid gas mixture from at least one other liquid gas tank.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B65D 90/44 - Means for reducing the vapour space or for reducing the formation of vapour within containers by use of inert gas for filling space above liquid or between contents
• F17C 13/12 - Arrangements or mounting of devices for preventing or minimising the effect of explosion
• F25J 1/00 - Processes or apparatus for liquefying or solidifying gases or gaseous mixtures
• F17C 13/00 - VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES - Details of vessels or of the filling or discharging of vessels
• F17C 9/00 - Methods or apparatus for discharging liquefied or solidified gases from vessels not under pressure
• B01D 53/047 - Pressure swing adsorption

Abstract

The present invention relates to an agent which inhibits Kallikrein-8 for use in the treatment or prevention of Alzheimer's disease and / or its precursor stages, as well as to methods, kits and uses relating thereto, including diagnostic tools.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• A61K 39/395 - Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor

Abstract

H has a sequence homology of at least 80% to the amino acid sequence WINTYTGEPT (SEQ ID No. 21).

IPC Classes  ?

• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 39/095 - Neisseria
• A61K 39/102 - Pasteurella; Haemophilus
• A61K 39/104 - Pseudomonas
• C12N 5/0783 - T cells; NK cells; Progenitors of T or NK cells

Abstract

The present invention relates to a method for predicting the degree of radiosensitivity of a cell by determining the number of prompt double-strand breaks (prDSBs) and predicting the degree of radiosensitivity of the cell based on the number of prDSBs. The present invention relates furthermore to a method for predicting the degree of radiosensitivity of a cell by determining the number of thermally labile sugar lesion-dependent double-strand breaks (tlDSBs) and predicting the degree of radiosensitivity of the cell based on the number of tlDSBs.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention provides an aerogel-concrete mixture, a high-performance aerogel concrete obtained therefrom, and a method for production thereof. The problem addressed by the present application is that of providing pressure-resistant but not very thermally conductive concretes, precast concrete components, screeds, screeds for precast components, (glassfibre-)reinforced concrete, fire protection panels, construction elements for thermal partition and blocks. The aerogel-concrete mixture contains: 10% to 85% by volume/m3 of aerogel pellets having a grain size in the range from 0.01 to 4 mm, 100 to 900 kg/m3 of inorganic hydraulic binder, 10% to 40% by weight based on the binder content of at least one silica gel suspension, 1% to 5% by weight based on the binder content of at least one plasticizer, 0.2% to 1% by weight based on the binder content of at least one stabilizer and 0% to 60% by volume/m3 of at least one lightweight aggregate. The method for producing an aerogel concrete with an aerogel-concrete mixture involves first mixing aerogel and any lightweight aggregates, then adding a water-silica mixture, a water-plasticizer mixture and the stabilizer, adding the inorganic binder during a suspension of mixing, and, after restarting the mixing, adding the remaining water and continuing to mix.

IPC Classes  ?

• C04B 28/04 - Portland cements

Abstract

The invention relates to a distributed energy conversion system, comprising at least a first energy conversion entity (EWE1) and a second energy conversion entity (EWE2), wherein the energy conversion entities (EWE1; EWE2) are connected among each other by means of an energy exchange network (EAN), and comprising an evaluation entity (BE), which can communicate with the energy conversion entities (EWE1, EWE2), wherein at a first time the first energy conversion entity (EWE1) acts as an energy supply element and the second energy conversion entity (EWE2) acts as an energy removal element, wherein the first energy conversion entity (EWE1) provides the evaluation entity (BE) with data regarding the provision of energy, wherein the data comprise one or more of the following: availability time period, availability amount, cost per unit of energy, pollutant amount per unit of energy, storage state for one or more future time periods, wherein the second energy conversion entity (EWE2) provides the evaluation entity (BE) with data regarding the removal and/or use and/or storage of energy, wherein the data comprise one or more of the following: removal time period, removal amount, storage state for two or more future time periods, wherein an evaluation of the provided data is then performed by means of the evaluation entity (BE) in order to create a schedule for the removal of energy, wherein the evaluation entity (BE) is part of the first energy conversion entity (EWE1) and/or is part of the second energy conversion entity (EWE2).

IPC Classes  ?

• H02J 3/14 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by switching loads on to, or off from, network, e.g. progressively balanced loading
• H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks

Abstract

An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element (2) fastened thereto, by means of which the sealing body is able to be fastened in the heart, preferably in the atrium of the heart, wherein the sealing body comprises at least one cavity (6), which is able to be filled with a fluid after implanting the sealing body and preferably not able to be emptied independently, and wherein, furthermore preferably, the sealing body remains expanded with constant volume during the cardiac phases as a result of the filling, wherein a plurality of cavities (6) are disposed about a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body or a single cavity (6) surrounds a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, wherein the main body (1) is embodied as a tube which is able to be bent out of the linear extent thereof and into the lateral surface of which a multiplicity of cuts have been introduced.

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element (2) fastened thereto, by means of which the sealing body is able to be fastened in the heart, preferably in the atrium of the heart, wherein the sealing body comprises at least one cavity (6), which is able to be filled with a fluid after implanting the sealing body and preferably not able to be emptied independently, and wherein, furthermore preferably, the sealing body remains expanded with constant volume during the cardiac phases as a result of the filling, wherein a plurality of cavities (6) are disposed about a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body or a single cavity (6) surrounds a main body (1) of the sealing body lying in the direction of longitudinal extent of the sealing body, wherein the main body (1) is embodied as a tube which is able to be bent out of the linear extent thereof and into the lateral surface of which a multiplicity of cuts have been introduced.

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

The invention relates to an implantable device for improving or treating a heart valve insufficiency, comprising a closure body (1) and at least one anchoring element fastened thereto, by way of which the closure body (1) can be fastened in the heart, preferably in the atrium of the heart. The anchoring element comprises a plurality of contact strips (2) extending between the closure body (1) and a shared connecting element (3) that is spaced from the closure body (1). The connecting element (3) can be brought into a first and a second position each spaced from the closure body, whereby the contact strips (2) undergo a change in shape, wherein in the first position, the connecting element (3) is spaced further apart from the closure body (1) than in the second position, and in the second position, the connecting element (3) is arranged between the contact strips (2).

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

The invention is directed to methods for delivery of HTRA polypeptides and its variants into mammalian cells without using transfection reagents. The HTRA polypeptides can be coupled to cargo molecules which are thereby transported into cells, e.g. for complementation, activation or inhibition of cellular pathways for basic and translational research as well as for therapy.

IPC Classes  ?

• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin

Abstract

The invention relates to a system for applying an implant (2), in particular a self-expanding implant (2), to an implantation site, preferably to a blood vessel or the heart, comprising a lock-forming catheter (1) and an implant (2) to be applied which is inserted therein, which can be transported through the lock-forming catheter (1) to the implantation site, in which the implant (2), on the side thereof which faces towards the implantation site, has a through element (3), through which a guide wire (6) in the lock-forming catheter (1) is fed, and a pusher catheter (7) is arranged in the lock-forming catheter (1), which encloses the guide wire (6) and can be pushed on the guide wire (6) towards the implantation site, and the through element (3) forms a non-penetrating stop for the end of the pusher catheter, which end points towards the implantation site. The invention also relates to an application device for applying an implant (2) and an implant for use with the system or the application device.

IPC Classes  ?

• A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord

Abstract

The invention relates to a body, in particular a thermoelectric element, comprising a sintered mixture of nanoparticles of at least one semiconductor element or semiconductor alloy, in particular silicone or germanium or the alloy thereof, each being in particular doped, and nanoparticles of at least one metal silicide, in particular a silicide of tungsten or molybdenum or iron. The invention also relates to a method for preparing a mixture of nanoparticles (5, 6), in particular having a size of less than 500 nm, in particular as a raw material mixture for sintering a sinter body, in which a mixture of gaseous precursors is generated in a gas phase, the precursors comprising at least one gaseous semiconductor compound and at least one gaseous metal compound, and wherein a reaction of the mixed precursors is initiated in the gas phase, said reaction producing the nanoparticles (5, 6) of the mixture, and the mixture of the nanoparticles (5, 6) is directly deposited from the gas phase. The invention further relates to a nozzle assembly for producing a mixture of nanoparticles.

IPC Classes  ?

• C04B 35/58 - Shaped ceramic products characterised by their composition; Ceramic compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxides based on borides, nitrides or silicides
• C22C 1/10 - Alloys containing non-metals
• C22C 29/18 - Alloys based on carbides, oxides, borides, nitrides or silicides, e.g. cermets, or other metal compounds, e. g. oxynitrides, sulfides based on silicides
• C22C 32/00 - Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ
• C01B 33/029 - Preparation by decomposition or reduction of gaseous or vaporised silicon compounds other than silica or silica-containing material by decomposition of monosilane
• C01B 33/06 - Metal silicides

Abstract

The invention relates to a method comprising a step of applying and depositing (100) of a semiconductor material-nanoparticle dispersion (HND) onto a first electrode (Ei) arranged on a substrate (S), the step of irradiating (200) laser light (L) onto the deposited semiconductor material-nanoparticle dispersion (HND) for forming a mu-cone (C1, C2) having a base and a tip, wherein the base of the mu-cone is connected to the first electrode (Ei). The method further comprises the step of embedding (300) the thus-formed mu-cone (C1, C2) in an electrically insulating polymer matrix (P), and the step of applying (500) a second electrode (E2) such that the tip of the mu-cone C1, C2) is connected to the second electrode (E2).

IPC Classes  ?

• H01L 21/329 - Multistep processes for the manufacture of devices of the bipolar type, e.g. diodes, transistors, thyristors the devices comprising one or two electrodes, e.g. diodes
• H01L 29/872 - Schottky diodes
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
• H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form

Goods & Services

Microscopes; Microscope video processors; Cameras; Electric and optical sensors; Photographic lenses; Lenticulars; Camera mounts; Image intensifiers; Image processors; Image analyzers; Apparatus for the processing of images; Image processing programs; Electronic cards for processing images; Test tubes; Microtiter plate; Shared autofocus systems for parallel lenses. Video recording, in particular of living cells; Video editing; Time-lapse video recording using microscopes. Scientific research, in particular relating to biology; Industrial research; Computerised scientific analysis, in particular image and video analysis; Clinical and medical research; Laboratory testing of materials; Scientific testing services; Chemical analytical examinations; Microscopy, in particular microscopic examination of samples in microtitre plates; Biological analysis; Biological laboratory services; Preparation of biological samples for testing and analysis in research laboratories; Materials analysis; Quality assurance in manufacturing technology; Active agent database examinations; Conducting of systematic test methods for filtering out purposes within a defined test range of elements having certain properties (screening tests). Clinical routine diagnostics.

Abstract

The invention relates to a pump (1) which is to be implanted into a vessel or a heart, wherein the pump (1) is inserted into the vessel or the heart in a first state, in order to then be able to be functionally changed over to a second state, said pump having • a drive part and • a delivery part (FE), • wherein the drive part is non-functional in the first state and becomes functional owing to the changeover to the second state, wherein the drive part has an electric motor, wherein the electric motor is in the form of a wet rotor, and wherein the rotor (R) of the electric motor is arranged separately from the stator (S) of the electric motor in the first state, and wherein the rotor (R) of the electric motor is moved into the stator (S) of the electric motor in the second state, wherein the rotor (R) can drive the delivery part (FE) in the second state.

IPC Classes  ?

• A61M 1/10 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
• A61M 1/12 - Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps implantable into the body

Abstract

The invention provides a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/553 - Metal or metal coated
• G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
• G01N 21/55 - Specular reflectivity

Abstract

The present invention relates to the use of exosome-preparations derived from neonatal or adult tissue-derived mesenchymal stem-cells (MSCs) for the prevention or for therapy of inflammatory conditions, such as, for example, pre- and postnatally acquired damages of the brain (i.e. neuronal damages) or in complications following stem cell transplantation (“graft vs host-disease”, GvHD).

IPC Classes  ?

• C12N 5/02 - Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor
• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/18 - Growth factors; Growth regulators
• A61K 38/19 - Cytokines; Lymphokines; Interferons
• A61K 38/20 - Interleukins
• A61K 38/21 - Interferons

Abstract

The present invention relates to methods and kits for classifying an individual as being at risk of developing Alzheimer's disease, in particular Alzheimer's disease type-dementia.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The invention pertains to a Method for assessing free text input, comprising the steps of: receiving a free text input, analysing the free text input using a first analysing method leading to a first rating, analysing the free text input using a second analysing method leading to a second rating, whereby said analysing methods may be statistical methods and/or regular expression based. A common rating is determined based on a weighted first rating and weighted second rating, whereby the weighting of the first rating and the second rating is predetermined. The method may be applied within a teaching environment as part of an automatic assessment system.

IPC Classes  ?

• G06F 17/27 - Automatic analysis, e.g. parsing, orthograph correction
• G06F 17/28 - Processing or translating of natural language

Abstract

The invention relates to an electrical capacitor comprising a first and a second electrode, both electrodes being interconnected by a medium, wherein the medium is formed by nano-particles of a semiconducting material. The invention discloses different material usable as a medium, for different reasons. The invention further disclosed a capacitor obtained through a dispersion and the associated method. A capacitor with an housing comprising a reservoir of water is also disclosed. A capacitor with particular dimension of electrodes is then claimed. A stripes capacitor is also claimed.

IPC Classes  ?

• H01G 11/56 - Solid electrolytes, e.g. gels; Additives therein

Goods & Services

Instructional and teaching material (except apparatus), periodicals, newspapers, magazines and books, in particular in the fields of shipping, naval engineering, offshore technology, marine technology, offshore wind farms, mechanics, fluid mechanics, numerics, measurement technology, solid mechanics, regulating technology and mathematics. Planning and conducting of congresses, conferences and instructional events; Publishing, other than printing, publication of books, newspapers and periodicals, in particular in the fields of shipping, naval engineering, offshore technology, marine technology, offshore wind farms, mechanics, fluid mechanics, numerics, measurement technology, solid mechanics, regulating technology and mathematics. Scientific research in the fields of shipping, naval engineering, offshore technology, marine technology, offshore wind farms, mechanics, fluid mechanics, numerics, measurement technology, solid mechanics, regulating technology and mathematics.

Abstract

In one aspect, catalytic membranes are described herein. In some embodiments, a catalytic membrane comprises a surface functionalized with a polymer, the polymer comprising cellulose solubilization functionalities and acid functionalities for the catalytic hydrolysis of cellulose and/or hemicellulose.

IPC Classes  ?

• B01D 71/06 - Organic material
• B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
• B01D 71/70 - Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• B01J 31/10 - Ion-exchange resins sulfonated
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• C13B 20/16 - Purification of sugar juices by physical means, e.g. osmosis or filtration
• C13K 13/00 - Sugars not otherwise provided for in this class
• C12M 1/00 - Apparatus for enzymology or microbiology
• B01J 19/24 - Stationary reactors without moving elements inside
• B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
• C13K 1/02 - Glucose; Glucose-containing syrups obtained by saccharification of cellulosic materials

Abstract

The present invention relates to a device for collimating electromagnetic radiation comprising a shielding structure at least partially surrounding a radiation source which has an opening in a transmission direction (A), a plurality of lamellae of a material that absorbs electromagnetic radiation which are positioned in the opening, and collimator channels between the lamellae which extend in the transmission direction (A), wherein the lamellae have a height (H) in the range of ≥ 10 µm to ≤ 3000 µm.

IPC Classes  ?

• A61N 5/10 - X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Abstract

The present invention relates to novel tumor-associated antigens,which elicit independently from a presentation via MHC a CD8-positive T-cell response. GM-CSF-Receptor alpha chain (CSF2RA) and Tyrosinase-related protein 2 (TRP-2) were found to be targets of CD8-positive T-cell clones which could detect the proteins on the surface of HLA I negative melanoma cells. Thus, the invention provides proteins, protein fragments and polypeptides of the novel antigens for use in medicine, for example for the treatment, diagnosis and prevention of a tumor disease. Furthermore provided are nucleic acids expressing the antigens of the invention, binding agents specific for the antigens of the invention, such as T-cell receptor chains and isolated T cells which are reactive against the antigens of the invention or which express the T-cell receptors of the invention. The invention further pertains to pharmaceutical compositions, especially vaccine compositions, comprising the antigens, nucleic acids, binding agents or T cells in accordance with the invention, and methods for the generation of T cells,which are specifically reactive to the antigens of the invention in an MHC-independent manner.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• C12N 15/00 - Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to a device suitable for housing one or more radiation sources for applying radiation to a target volume on or within the eye, comprising a housing, the housing comprising an inner calotte, and a rim coupled to the perimeter of the inner calotte, and an outer calotte, wherein the thickness of the rim defines a cavity between the inner calotte and the outer calotte, which is configured to accept one or more radiation sources, and wherein the housing comprises one or more fastening elements by means of which the outer calotte is fastened releasable to the inner calotte and/or to the rim.

IPC Classes  ?

• A61N 5/10 - X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Abstract

The present invention relates to the use of exosome-preparations derived from neonatal or adult tissue-derived mesenchymal stem-cells (MSCs) for the prevention or for therapy of inflammatory conditions, such as, for example, pre- and postnatally acquired damages of the brain (i.e. neuronal damages) or in complications following stem cell transplantation ("graft vs host-disease", GvHD).

IPC Classes  ?

• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The invention pertains to a Method for using and generating a map, in particular an indoor map, allowing for localizing a position based on one or more detected wireless signals originating from one or more sources (SRC1, SRC2, SRC3, SRC4), whereby a source (SRC1, SRC2, SRC3, SRC4) is selected from the group comprising near field communication device, mobile telephone, W-LAN access point, Bluetooth access point, etc.. The method comprises a step of detecting (100) at certain positions (Ρ1, P2, P3, P4); each of said certain positions corresponding to a position on the map, by a plurality of detectors (MD1, MD2, MD3, MD4) at substantially the same time at least one wireless signal originating from at least one of said one or more sources (SRC1, SRC2, SRC3, SRC4) with respect to its signal strength. The plurality of detectors (MD1, MD2, MD3, MD4) are arranged such that they reflect different positions of a corresponding user device (UD1, UD2) and its physical characteristics such as attenuation or scattering when worn by a user at the human body, thereby allowing for providing detected signal strengths with respect to different orientations. The method comprises also as step of storing (200) said signal strengths of each detected wireless signal originating from said one of said one or more sources (SRC1, SRC2, SRC3, SRC4) with respect to the plurality of detectors (MD1, MD2, MD3, MD4) and the certain position. Thereafter the method allows for provisioning (300) of said map. Afterwards a user device (UD1, UD2) may detect (400) at an unknown position a number of wireless signals and their signal strength, and the method allows for comparing (500) said wireless signals detected by said user device (UD1, UD2) with said stored signal strengths with respect to at least a best match in order to ensure that a certain position of the user device (UD1, UD2) with respect to a human body and its physical properties are correctly taken into account. The invention also pertains to an appropriate Measurement arrangement for generating a map, in particular an indoor map, as well as for a user device (UD1, UD2) for using a map.

IPC Classes  ?

• G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinations; Position-fixing by co-ordinating two or more distance determinations using radio waves

Abstract

The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. Th e method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.

IPC Classes  ?

• A61M 11/00 - Sprayers or atomisers specially adapted for therapeutic purposes
• A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The invention relates to an implantable device for improving or rectifying a heart valve insufficiency, comprising a closure element (1) which can be positioned in the passage area of a heart valve, in particular in the area between an atrium (2) and a ventricle (3) of the heart, and which has an upper, upstream end (1a) and a lower, downstream end (1b), wherein at least one contact strip (4) is arranged at at least one of the ends (1a, 1b) of the closure element (1), which extends away from the closure element (1) and is led back to the closure element (1) in at least one loop, wherein at least a part of the extent of the strip can be placed against the inner wall of the heart.

IPC Classes  ?

• A61F 2/24 - Heart valves

Abstract

The invention relates to an in vitro method for predicting disease risks, progression of diseases, drug risks, success of treatment and for finding drug targets by looking for one or more genetic modifications in the promoter region of the CHK1 (CHEK1) gene on human chromosome 11q23, the genetic modifications being a substitution thymine for guanine in position −1143 in the promoter of CHK1, of thymine for cytosine in position −1400, a substitution of cytosine for thymine in position −1453 or an insertion of one cytosine in position −1454 and the genetic modifications being detected individually or in any combinations by way of known methods.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method and to an apparatus for determining a measure of the linear energy transfer (LET) of ionizing photon and/or particle radiation, characterized in that a detector unit, comprising a first detector, having a first material that is stimulatable to luminescence, and comprising a second detector, having a second material that is stimulatable to luminescence and differs from the first one, is subjected to ionizing photon and/or particle radiation for the duration of a capturing period, and, after the capturing period, after or during a stimulation, a first luminescence signal is captured by the first detector and a second luminescence signal is captured by the second detector, and the respective luminescence signals or corrected signals that are dependent thereon are in each case integrated, and a ratio of the integrals is calculated that represents a measure of the linear energy transfer.

IPC Classes  ?

• G01T 1/10 - Luminescent dosimeters
• G01T 1/11 - Thermo-luminescent dosimeters

Abstract

The invention relates to the use of gene modifications in the human gene CHK2 (CHEK2), which encodes the checkpoint kinase 2, for predicting the risk and progression of cancer diseases, for predicting the response to pharmacological or non-pharmacological therapeutic measures for treating cancer diseases, and for predicting undesired effects of drugs. The invention further relates to the provision of individual gene variants with the help of which further gene modifications that can be used for the aforementioned purposes can be detected and validated. Such gene modifications can comprise a substitution of adenine for guanine in position −7161 in the promoter of CHK2, a substitution of guanine for cytosine in position −7235, a substitution of adenine for guanine in position −10532, or a deletion of 29 base pairs in positions −10621 to −10649.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

There is provided a method for eliminating a tumor cell with a hyperactivated B-Raf or hyperactivated Ras kinase and increased DUSP6 activity. Specifically, the invention provides a method of contacting a tumor cell with a hyperactivated B-Raf kinase or a hyperactivated Ras kinase with an agent that reduces DUSP6 activity. Also, there is provided a diagnostic test for therapy responder prediction.

IPC Classes  ?

• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 35/00 - Antineoplastic agents
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a method and to a system for determining the position and/or location of an object (8,11) in a spatial measurement volume (V), in which the measurement volume (V) is formed by optically modulating a divergently propagating light bundle (2"') two-dimensionally over its cross section using a light modulator (4) in a predetermined number of cross-section units, wherein an in particular different temporal optical modulation is impressed onto the light beams (7a, 7b, 7c) of each cross-section unit and at least one detector (8) is used to capture a sum reception signal (IPD) of all the transmission signals (S) of those light beams (7a, 7b) that are incident on an object (8,11) in the measurement volume (V), and an analysis is carried out with respect to which of the transmission signals (S) make a contribution to the sum reception signal (IPD), wherein the position and/or the location of the object (8,11) in the measurement volume (V) is determined from the analysis.

IPC Classes  ?

• G01B 11/25 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures by projecting a pattern, e.g. moiré fringes, on the object

Abstract

This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.

IPC Classes  ?

• A61K 31/6615 - Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• C07F 9/40 - Esters thereof
• C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds

Abstract

An implantable electrode device, in particular for a cardiac pacemaker, a corresponding stimulation system and a method for operating at least two implantable electrode devices are proposed. A simplified implantation, an efficient construction and reliable control are enabled by the electrode device being supplied with energy, and preferably controlled, in an exclusively wireless manner via a time-variable magnetic field. The magnetic field is generated by an preferably implanted control device.

IPC Classes  ?

• A61N 1/378 - Electrical supply
• H02M 3/335 - Conversion of dc power input into dc power output with intermediate conversion into ac by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate ac using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only

Abstract

The invention relates to a method for detecting and/or finding at least one gene modification, in particular a mutation, in a gene, preferably in a gene that codes for a protein connected to a tumor disease and/or cancer disease, in particular wherein the gene (mutation gene) having the gene modification is present together with further genes (wild-type genes) that code for the protein but do not have a gene modification. The method according to the invention is characterized in that a detectable hybridization probe (sensor probe) is used to detect the gene modification. The hybridization probe (sensor probe) is able to interact and/or interplay with, in particular to bind to, the gene (wild-type gene) having no gene modification and the gene (mutation gene) having the gene modification, wherein the hybridization probe (sensor probe) has a higher specificity and/or binding affinity and/or selectivity for the gene (wild-type gene) having no gene modification than for the gene (mutation gene) having the gene modification.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to a hybrid compound based on aminopyrazol derivatives and peptides, for use as a therapeutic agent in treating illnesses wherein an aberrant protein aggregation or protein multimerization, or a protein folding error, plays a role. The invention further relates to a method for producing said compounds.

IPC Classes  ?

• C07K 7/04 - Linear peptides containing only normal peptide links
• A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

Abstract

The invention relates to a neutron detector comprising a first (3a) and a second (3b) sensor device, both being sensitive to gamma rays, the first sensor device (3a) being covered with Gadolinium (5), the covered first sensor device (3a) and the second sensor device (3b) each being placed in a housing (2) consisting of or at least comprising a gamma ray attenuating material, in particular lead, the housings (2) of both sensor devices (3a, 3b) being positioned adjacent to each other in a bulk, in particular the middle of a bulk of a neutron moderating material (1). The invention furthermore relates to a method of detecting neutrons emerging from an area of interest to a neutron detector, in particular a detector according to any one of the preceding claims, comprising the steps of decelerating the neutrons to thermal energy by means of a moderator material (1), attenuating the gamma rays emitted by the moderator material (1) during the deceleration, in particular by means of lead, irradiating a first and a second sensor device (3a, 3b) which are both sensitive to gamma rays with the attenuated gamma rays, capturing the thermalised/decelerated neutrons with Gadolinium (5) and producing gamma rays in a neutron-Gadolinium-interaction, irradiating only the first sensor device (3a) and preventing irradiating of the second sensor device (3b) with the gamma rays produced in Gadolinium (5), reading a signal proportional to the received total fluence of gamma rays from both sensor devices (3a, 3b).

IPC Classes  ?

• G01T 3/00 - Measuring neutron radiation

Abstract

The invention relates to the use of at least one quantitative ratio (quotient) of two amyloid beta peptidea (A beta; Aß) which are different from one another in a sample of a bodily fluid of a test subject and/or patient in order to determine the probability (risk) of said test subject and/or patient suffering Alzheimer's disease (Morbus Alzheimer, AD) and/or to determine (diagnose) suffering from an early stage of Alzheimer's disease, wherein the amyloid beta peptides are selected from (a) Aß(1-42), (b) Aß(2-40) and (c) Aß(2-42) and wherein the quantitative ratio of (a) / (b) or vice versa and/or of (a) / (c) or vice versa is formed. The invention also relates to a corresponding method and to a kit for use in this connection.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to a sole (1) for a shoe for increasing the instability during stepping, wherein the sole (1) preferably extends from a rear heel area across a metatarsal area to a front foot area. According to the invention, in the area of the gait line (2) the sole (1) has an instability region (3) that substantially follows the contour of the gait line (2) and that extends at least in some sections in the longitudinal direction of the sole (1). The instability region has an increased bulk modulus relative to the adjacent medial and/or lateral outer areas (6, 7) of the sole (1).

IPC Classes  ?

• A43B 7/00 - Footwear with health or hygienic arrangements
• A43B 13/14 - Soles; Sole-and-heel integral units characterised by the constructive form
• A43B 13/18 - Resilient soles

Abstract

In order to cultivate organisms, gas is introduced into a vessel containing a medium with the organisms via a stirrer, the drive shaft thereof, or along an axis of rotation of the stirrer.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/02 - Apparatus for enzymology or microbiology with heat exchange means
• C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means

Abstract

In order to three-dimensionally distribute light in a liquid medium, a chain of bubbles that is illuminated and acts as an optical waveguide is generated in the medium.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

IPC Classes  ?

• C07D 231/38 - Nitrogen atoms
• A61K 31/415 - 1,2-Diazoles
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The invention relates to a method for verifying and/or for detecting at least one gene modification, in particular a mutation, in a gene, preferably in a gene that codes for a protein connected with a tumor disease and/or cancer disease, in particular wherein the gene (mutation gene) having the gene modification is present together with further genes (wild-type genes) that code for the protein but do not have a gene modification. The method is carried out by means of asymmetric polymerase chain reaction, or PCR, under the combined use of at least one detectable mutation-specific hybridization probe (sensor probe) and at least one wild-type-specific blocking agent that inhibits the connection of the sensor probe to the wild-type genes, in particular in such a way that the detection is selectively intensified and/or amplified in regard to a gene segment, in particular a DNA segment, of the mutation gene that has the gene modification.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to an anti-HSV antibody as defined in the claims, a pharmaceutical composition comprising of an effective amount of the said antibody, an expression vector comprising of a nucleotide sequence which encodes the said antibody, a host cell comprising of the said nucleotide sequence, a hybridoma cell capable of producing the said antibody and the use of the said antibody as a drug, in particular to use for the manufacture of a drug for the prophylactical or therapeutical treatment of HSV-associated diseases in a subject; as defined in the claims.

IPC Classes  ?

• C07K 16/08 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses
• C07K 14/035 - Herpes simplex virus I or II

Abstract

A method as well as a transmitter, a receiver and an adaption layer allowing transmission and/or reception of payload data with a high data rate is described. A high data rate platform (502, 504) and a low data rate platform (506, 508) are provided. The payload data is transmitted and/or received via the high data rate platform (502, 504), while the signaling data associated with the payload data is transmitted and/or received via the low data rate platform (506, 508).

IPC Classes  ?

• H04W 72/04 - Wireless resource allocation

Abstract

A relay station and a method for relaying signals between a first signal source (S1) and a second signal source (S2) are described. The relay station (R) comprises at least two antennas (ANTR1, ANTR2) for receiving/transmitting signals from/to the first and second signal sources (S1, S2). At the relay station (R) first and second signals received from the first and second signal sources (S1, S2) are network coded thereby generating a first network coded signal and a second network coded signal. The first and second network coded signals are transmitted from the relay station (R) to the first and second signal sources (S1, S2) using different antennas (ANTR1, ANTR2).

IPC Classes  ?

• H04B 7/04 - Diversity systems; Multi-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas
• H04B 7/26 - Radio transmission systems, i.e. using radiation field for communication between two or more posts at least one of which is mobile
• H04W 88/04 - Terminal devices adapted for relaying to or from another terminal or user
• H04L 1/06 - Arrangements for detecting or preventing errors in the information received by diversity reception using space diversity

Abstract

A transmitter (100) for transmitting an optical signal based on a baseband signal, comprising a means (110) for up-transforming the baseband signal to obtain a bandpass signal and a means (120) for converting the bandpass signal into a signal having a DC-offset. The transmitter (100) further comprises a means (130) for modulating a light source (140) with the signal having the DC-offsets to transmit the optical signal.

IPC Classes  ?

• H04B 10/112 - Line-of-sight transmission over an extended range
• H04B 10/114 - Indoor or close-range type systems
• H04B 10/50 - Transmitters
• H04B 10/58 - Compensation for non-linear transmitter output
• H04B 10/60 - Receivers

Abstract

The invention relates to an electrochemical concentration and/or separation of algae from an algae suspension.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The present application discloses a method for treating a population of in particular biological objects that are different from each other and suspended in fluid droplets comprising a target and residual particle population, using at least one substrate and one digital microfluidic circuit or controller allowing digital microfluidic droplet displacement, wherein fluid droplets of suitable composition are generated from target and residual particles, and each fluid droplet is analyzed in a first analysis position for the presence of at least one target or residual particle, wherein fluid droplets without target particles are subsequently remove from the substrate by means of a residual particle sump and fluid droplets having at least one target particle or a prescribed minimum number of target particles are fed to a next treatment stage by means of the substrate.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers

Abstract

This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.

IPC Classes  ?

• C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
• C07F 9/40 - Esters thereof
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The invention relates to the use of gene modifications in the human gene CHK2 (CHEK2), which encodes the checkpoint kinase 2, for predicting the risk and the progression of cancer diseases, for predicting the response to pharmacological or non-pharmacological therapeutic measures for treating cancer diseases, and for predicting undesired effects of drugs. The invention further relates to the provision of individual gene variants with the help of which further gene modifications that can be used for the aforementioned purposes can be detected and validated. Such gene modifications can comprise a substitution of adenine for guanine in position -7161 in the promoter of CHK2, a substitution of guanine for cytosine in position -7235, a substitution of adenine for guanine in position -10532, or a deletion of 29 base pairs in positions -10621 to -10649.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

The invention relates to methods of modifying endothelial cells of corneal tissue to express an anti-apoptotic gene, to prevent endothelial cell loss during cornea storage and to improve the quality of cornea tissue prior to transplantation. The invention also relates to a kit for cornea storage comprising a media, an anti- apoptotic gene and a vector.

IPC Classes  ?

• C12N 5/079 - Neural cells