The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses means and methods for single molecule protein sequencing and/or amino add identification using cleavage inducing agent. Said cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics of said reaction.
The invention relates to the field of CAR-T cell immunotherapy, more specifically the invention relates to production and uses of glyco-engineered CAR-T cells for the improvement of immunotherapy compositions for treatment of cancer, more specifically of solid tumors. The invention specifically relates to human CAR-T cells with a mutated MGAT5 gene, as to provide for surface glycan structures devoid of tetra-antennary N-glycans, which results in a sustained memory when applied in immunotherapy, to cure cancer, reduce (recurrent) tumor growth and tumor burden, as well as to prevent relapse. The invention further relates to methods for manufacturing of those CAR-T cells, wherein addition of low amounts of DMSO during activation and expansion ex vivo skews T cell populations to a more predominant memory phenotype, thereby providing for improved glycol-engineered CAR-T cell compositions for adoptive T cell transfer.
The invention relates to a method to deink and/or to delaminate plastic material, preferably to a method to deink and delaminate plastic material in a single step. The method comprises the step of contacting the plastic material with an amine or a composition comprising said amine, wherein the amine comprises a nitrogen atom having at least one hydrocarbon substituent comprising an acyclic or cyclic alkyl group. The total number of carbon atoms of all hydrocarbon substituents of the nitrogen atom is at least (5).
C08J 11/28 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by treatment with organic material by treatment with organic compounds containing nitrogen, sulfur or phosphorus
5.
SOLUTION ELECTROSPUN FIBERS, COMPOSITIONS COMPRISING THE SAME AND A PROCESS OF MANUFACTURING THEREOF
The present invention relates to solution electrospun fibers comprising a ingredient in an amorphous form, compositions and their manufacturing process thereof. More specifically, the present invention relates to solution electrospun fibers and a compositions comprising at least one of said fibers, said fiber obtained by solution electrospinning a ingredient with a polymer.
A method and a circuitry to perform clock and data recovery, CDR is provided. The method includes the steps of obtaining an analogue communication signal characterized by a symbol frequency Fsymbol; and performing an analogue-to-digital conversion of the analogue communication signal according to a sampling rate Fsample targeting Fsymbol*(M/L) thereby obtaining a digital signal. The method includes up-sampling the digital signal by L; filtering the up-sampled digital signal with filter coefficients of a finite impulse response, FIR, filter to perform a fractionally-spaced equalisation; and down-sampling the filtered digital signal by M resulting in a recovered digital signal. Intermediate filter coefficients are obtained for the FIR filter and a phase error is determined based on the recovered digital signal. The intermediate filter coefficients are interpolated based on the phase error to compensate for the phase error, resulting in interpolated filter coefficients; and the filter coefficients of the FIR filter are updated with the interpolated filter coefficients.
H04L 7/033 - Speed or phase control by the received code signals, the signals containing no special synchronisation information using the transitions of the received signal to control the phase of the synchronising-signal- generating means, e.g. using a phase-locked loop
H04L 7/00 - Arrangements for synchronising receiver with transmitter
7.
THERMOMETRIC COMPOSITION COMPRISING BIODEGRADABLE PERIODIC MESOPOROUS ORGANOSILICA AND AT LEAST TWO DYES
Provided herein is a thermometric composition, comprising a plurality of biodegradable periodic mesoporous organosilica, B-PMO, particles, wherein: - each B-PMO particle is loaded with a first dye and a second dye, - the first dye and second dye are both fluorescent, - a fluorescent light emission by the first dye causes a luminescent excitaon of the second dye, - the first dye and/or the second dye exhibit(s) a temperature-dependence fluorescence. Further is provide a method for preparing such thermometric composition, and a method for obtaining temperature data of a cell, a tissue or a subject, using such thermometric composition.
The present invention provides a lipid nanoparticle comprising a fentanyl hapten, and a T helper peptide and/or an adjuvant, wherein the fentanyl hapten is conjugated to the outer surface of the lipid nanoparticle, and wherein the T helper peptide and/or the adjuvant is/are encapsulated within the lipid nanoparticle. The invention further provides a pharmaceutical composition comprising the lipid nanoparticle and uses thereof for inducing an immune response against fentanyl and the prevention or treatment of a fentanyl abuse disorder or a fentanyl addiction or a fentanyl overdose in a subject. Further provided herein is a method for preparing the lipid nanoparticle of the invention.
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
The invention provides a method for regioselective functionalizing a surface of an electron microscopy grid (10), therefore:
a) providing a surface (20) of an electron microscopy grid (101);
b) providing a plurality of wall systems (30A, 30B) on the surface of an electron microscopy grid, thereby forming a plurality of temporary reaction chambers (40A, 40B);
c) providing a modification solution (50) in each temporary reaction chambers (40A, 40B);
d) modifying the parts of the surface (21A, 21B) in the temporary reaction chambers (40A, 40B) with the modification solution(s) (50, 50A, 50B);
e) removing the modification solution(s) (50, 50A, 50B) from the temporary reaction chambers (40A, 40B);
f) removing the plurality of wall systems (30A, 30B) from the surface (20).
The invention provides a method for regioselective functionalizing a surface of an electron microscopy grid (10), therefore:
a) providing a surface (20) of an electron microscopy grid (101);
b) providing a plurality of wall systems (30A, 30B) on the surface of an electron microscopy grid, thereby forming a plurality of temporary reaction chambers (40A, 40B);
c) providing a modification solution (50) in each temporary reaction chambers (40A, 40B);
d) modifying the parts of the surface (21A, 21B) in the temporary reaction chambers (40A, 40B) with the modification solution(s) (50, 50A, 50B);
e) removing the modification solution(s) (50, 50A, 50B) from the temporary reaction chambers (40A, 40B);
f) removing the plurality of wall systems (30A, 30B) from the surface (20).
The invention further provides in an electron microscopy grid to be regioselective functionalised and an apparatus for regioselective functionalizing a surface of an electron microscopy grids.
Provided is a method or system method for determining a likelihood of a test subject having epilepsy after having suffered a possible epileptic seizure, comprising: - receiving measurement data comprising a measurement parameter set derived from an EEG recording of the test subject in a resting state wherein the measurement parameter set comprises Parameter A of Table 1, - determining from the measurement data the likelihood of the test subject having epilepsy.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
11.
Crystal Structures of ALK and LTK Receptor Tyrosine Kinases and Their Ligands
The present invention provides co-crystals of the anaplastic lymphoma kinase (ALK) and its ligand ALKAL2 and the related leukocyte tyrosine kinase (LTK) and its ligand ALKAL1. The invention also provides computer-assisted and other methods for selecting molecules able to modulate the interaction between ALK, LTK and their respective ligands.
A system for open-path sensing of a property of a fluid in an environment comprises: a sensing light source; a pumping light source for outputting a pumping beam into the environment for inducing a change of light propagation characteristics of the fluid; wherein the system outputs a probing beam and a reference beam into the environment, such that the probing beam has a larger intersection with the pumping beam than the reference beam; wherein a first interferometer detects a phase shift and/or an intensity change of a received probing beam; and wherein a second interferometer detects a phase shift and/or an intensity change of a received reference beam.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01F 1/661 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters using light
G01M 3/04 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 21/85 - Investigating moving fluids or granular solids
13.
HAFNIUM (IV) OXIDE NANOPARTICLES AND AQUEOUS COMPOSITIONS THEREOF
The invention relates to a hafnium (IV) oxide (HfO2) nanoparticle nanocrystal comprising or having a diameter equal or less than (≤) 15 nm, stabilized by a plurality of dispersant molecules attached to its surface. The dispersant molecules comprise of a catechol or gallol surface adsorption moiety and an oligo (ethyleneglycol) moiety. The invention further relates to a composition of such nanoparticles in stable colloidal suspension at physiological pH, and the use of the composition in medical treatment and diagnostic applications, particularly to enhance radiotherapy and as an X ray contrast agent. In yet another aspect, the invention provides a method for manufacturing compositions and nanoparticles according to the invention.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
The present invention relates to the field of genome-editing, more specific of difficult to transform organisms such as e.g. invertebrates and in particular Arthropoda. The present disclosure provides a combination comprising one or more cationic nanoparticles, one or more endosomal escape reagent(s), and one or more ribonucleoprotein (RNP) complexes wherein said RNP comprises a Cas RNA-guided nuclease associated with a guide RNA (gRNA), and the use thereof in the production of a non-human genetically modified organism. The invention further provides a combination as defined herein for use in CRISPR based methods.
A01K 67/61 - Genetically modified invertebrates, e.g. transgenic or polyploid
C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/90 - Stable introduction of foreign DNA into chromosome
The present application provides methods for determining a respiratory health of a test subject based on mass spectrometry data of a sample of exhaled breath of the test subject. Also provided are methods for assessing the efficacy of a therapeutic treatment of a respiratory disease in a test subject based on mass spectrometry data of one or more samples of exhaled breath of the test subject. Further provided are systems or devices for use in said methods and the use of said systems or devices.
Norwegian University of Science and Technology (NTNU) (Norway)
Universiteit Gent (Belgium)
Inventor
Jahre, Magnus
Gottschall, Björn
Eeckhout, Lieven
Abstract
Profiling circuitry for a processor includes state-determining circuitry that is configured to access information stored by the processor for committing inflight instructions in program order, and to use this information to determine a commit state of the processor. The profiling circuitry also has sampling circuitry which is configured, when the processor is in a first commit state, to output sample data to a sample register or a memory that identifies one or more instructions that are next to be committed by the processor, and, when the processor is in a second commit state, to output sample data to the sample register or memory that identifies an instruction that was last committed by the processor.
The present invention relates to mutated chitin oligosaccharide synthases and their usage to produce molecules having useful features. More specifically, the present invention discloses the usage of engineered microorganisms expressing a mutated chitin oligosaccharide synthase to produce chitin oligosaccharides having a degree of polymerization of four, five, six or seven.
C12P 19/18 - Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
According to an embodiment a chamber unit (101) is disclosed for a gas-liquid vortex reactor (500) for contacting a first with a second fluid stream comprising a circumferential wall (400, 401) enclosing a cylindrically shaped mixing chamber and a set of tangentially distributed fluid inlet slots (406, 407) axially running from a bottom to a top base to supply the first stream from the outer surface of the wall (400, 401) into the chamber, the wall (400, 401) further comprising a first set of inner axially running between the bottom base towards the top base and comprising a supply inlet (402) at a first end at the bottom base, and a discharge outlet (403) at a second end radially extending from the inner conduit to the inner surface of the wall (400, 401) wherein the inner conduit is configured to supply the second stream from the bottom base into the chamber.
B01J 4/00 - Feed devicesFeed or outlet control devices
B01F 25/10 - Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
B01J 19/18 - Stationary reactors having moving elements inside
B01J 19/26 - Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
19.
DENDRITIC CELLS LOADED WITH LYSATES FROM LATE FERROPTOTIC CELLS TO TREAT CANCER
The present invention relates to the field of immunotherapeutical compositions which can be used to treat cancer. More in particular, the present invention discloses dendritic cells loaded with lysates derived from late ferroptotic cancer cells which are useful to treat cancer.
A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
A61K 39/00 - Medicinal preparations containing antigens or antibodies
The present invention relates to the field of tissue regeneration, particularly the field of skin lesions such as wounds, more particularly chronic wounds. The invention provides wound healing compositions. Specifically, the invention provides molecules targeting the Slc7a11 transporter such as antibodies, shRNA, siRNA, locked nucleic acids, peptide nucleic acids and morpholinos for use to treat chronic wounds such as for example diabetic wounds.
A method is provided for deriving a surface profile of a free-form master lens for patterning one or two photo-alignment layers of a planar optical component. The method includes obtaining a desired optical function of the planar optical component; and obtaining an actual optical function of the planar optical component, the actual optical function being described as recorded using a free-form test lens with a surface profile configured to provide the desired optical function. The method includes estimating a deviation between the desired optical function and the actual optical function; and correcting the surface profile of the free-form test lens using the estimated deviation, thereby deriving a surface profile for the free-form master lens.
There is provided a rotation device comprising a rotor, a stator, a target component, and a sealing device. The rotor is arranged to rotate along a rotation axis relative to the stator. The stator is arranged radial outward of the rotor to form a gap between the rotor and the stator. The sealing device is attached to the rotor to hydrodynamically seal the g against a fluid. The sealing device is adapted to direct the fluid to the target component to exchange heat between the target component and the fluid, and/or to lubricate the target component with the fluid.
F01D 11/04 - Preventing or minimising internal leakage of working fluid, e.g. between stages by non-contact sealings, e.g. of labyrinth type using sealing fluid, e.g. steam
VCcdlcdl cdl , for each candidate delivery location (130, a to c) which is related to an accessibility of the candidate delivery location (130, a to c) by a tip (202) of the vascular catheter (200), wherein the evaluating comprises using the vascular cost for each candidate delivery location (130, a to c) and a likelihood that the substance flowing from the candidate delivery location (130, a to c) towards the target will flow through one or more arterial branches converging with the target and into the target when delivered at the candidate delivery location (130, a to c) by the tip of the vascular catheter.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61K 9/00 - Medicinal preparations characterised by special physical form
24.
OPTICAL OUTCOUPLING COMPONENT, WAVEGUIDE DEVICE AND METHOD FOR MANUFACTURING SAID OPTICAL OUTCOUPLING COMPONENT
Optical outcoupling component configured to couple light out of a waveguide device, wherein the outcoupling component includes at least one substrate and at least one optically active layer, wherein the at least one optically active layer includes first areas configured to transmit light without outcoupling, and second areas configured to outcouple at least part of the light.
The present invention relates to the field of antibody-drug-conjugates (ADCs) and the application of glyco-engineering strategies in a novel site-specific conjugation technology. The invention particularly relates to ADCs wherein a drug entity is conjugated an aminooxy-functionalized linker at di- or trisaccharide N-glycans in the hinge region, and methods for producing the same. More particularly, said conjugate is obtained through oxidized galactose- or sialyl-groups obtained from glyco-engineered eukaryotic cells which produce antibodies with an N-glycan structure that is limited to a shortened Asn- GlcNac-Gal(-Sia) branch in the hinge region of the antibody.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
26.
DEVICE AND METHOD FOR CLOCK SYNCHRONISATION IN A WIRELESS NETWORK
A device for wireless communication according to a standard communication protocol adapted to operate at the Physical layer and/or Medium Access Control layer of the protocol, and includes a Wireless Network Interface Controller, abbreviated WNIC, the WNIC having: a transmitter and receiver; a WNIC clock, implementing a local timer according to the standard communication protocol. The device further includes: an interface adapted to receive offset correction information and skew correction information from one or more higher protocol layers; an offset correction unit adapted to correct the reference time of the WNIC clock based on the offset correction information; a skew correction unit adapted to correct the frequency of the WNIC clock based on the skew correction information.
An overload clutch comprising an input flange and an output flange, said clutch being configured to transmit torque between the input flange and the output flange and to disengage the clutch when the torque exceeds a predetermined threshold, characterised in, that the clutch comprises one or more sensing means at least partially integrated in at least one of the input and output flanges, and that the one or more sensing means are adapted to jointly determine the torque applied to transmitted between the input flange and the output flange of the clutch and to detect the disengagement of the clutch. A device comprising the clutch, a gear unit connected to the input flange, and a motor connected to the gear unit, configured to provide torque to the input flange through the gear unit.
Norwegian University of Science and Technology (NTNU) (Norway)
Universiteit Gent (Belgium)
Inventor
Jahre, Magnus
Gottschall, Björn
Eeckhout, Lieven
Abstract
A processing system has a processor and profiling circuitry. The processor is configured to commit instructions in a program order, and comprises circuitry for determining and storing performance-event data for each instruction committed by the processor. The performance-event data for each instruction indicates whether the instruction experiences any of a predetermined set of one or more performance events. The profiling circuitry generates sample data at intervals, and writes the sample data to a sample register or memory. The sample data generated at each interval identifies one or more instructions that are next-to-be committed by the processor or one or more instructions that were last committed by the processor, and comprises the respective performance-event data for each of the identified instructions.
A laser apparatus is described herein which includes a laser diode for emitting a laser beam, configured for frequency modulation of the laser beam; a sensor unit configured to receive a first portion of the laser beam, and for measuring variations of the frequency of the first portion; and a phase shifter arranged in a path of a second portion of the laser beam, and configured to phase shift the second portion. The laser apparatus is configured to output the second portion having propagated through the phase shifter, and to acquire measurements of variations of the frequency during frequency modulation at different phase shifts, and to control the phase shifter based on the measurements to control the variations of the frequency, whereby the laser apparatus may control a linewidth of the laser beam in dependence of an external reflection of the output laser beam, received by the laser apparatus.
H01S 5/06 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium
H01S 5/026 - Monolithically integrated components, e.g. waveguides, monitoring photo-detectors or drivers
H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
30.
POLYMERS FOR DELIVERY OF ACTIVE AGENTS, COMPOSITIONS COMPRISING SAID POLYMERS, AND USES THEREOF
The present invention relates to a polymer for delivery of active agents. Said polymers comprising amino acid derivatives, such as cationic polymers comprising amino acid derivatives, wherein the polymer according to the invention may also be referred to as PiPOx-XXX, wherein XXX refers to the amino acid derivative. Furthermore, the invention also relates to a composition comprising said polymer and use thereof.
C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
C08F 8/32 - Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
31.
AMINOPEPTIDASE N-SPECIFIC MONOCLONAL ANTIBODIES AND USES THEREOF
The present invention relates to antibodies and antigen-binding fragments that bind specifically to amino peptidase N, fusion constructs and uses thereof, in particular for the targeted delivery of molecules. More specific, the invention provides methods for vaccination, in particular oral vaccination inducing both mucosal and systemic immune responses and methods for treating, reducing or preventing gastrointestinal diseases using said antibodies or fragments.
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
INSTITUUT VOOR LANDBOUW- EN VISSERIJONDERZOEK (ILVO) (Belgium)
Inventor
Goormachtig, Sofie
Vlaminck, Lena
Willems, Anne
Pannecoucque, Joke
Abstract
The present invention relates to the field of sustainable agriculture. In particular, the present invention relates to isolated Bradyrhizobium bacteria having enhanced characteristics, including but not limited to enhanced adaptation to the low and medium root zone temperature for example in North-West Europe.
The present invention relates to the field of microbial growth, more specifically microbial overgrowth, even more specifically overgrowth of Enterobacteriaceae, specifically under conditions of apoptosis in the gut such as IBD, colitis, chemotherapy and food borne bacterial infections. The present invention provides inhibitors of a bacterial target, pyruvate formate lyase, which can be used to regulate the overgrowth of Enterobacteriacea.
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
According to an aspect there is provided an optical monitoring device comprising:
a first input for receiving a portion of a first optical signal coupled from a first waveguide into the first input;
a second input for receiving at least a portion of a second optical signal coupled into the second input;
a mixing unit for controlling combining of the portion of the first optical signal with the at least a portion of the second optical signal into a combined signal at an output from the mixing unit; and
at least one photodetector for detecting the combined signal.
According to an aspect there is provided an optical monitoring device comprising:
a first input for receiving a portion of a first optical signal coupled from a first waveguide into the first input;
a second input for receiving at least a portion of a second optical signal coupled into the second input;
a mixing unit for controlling combining of the portion of the first optical signal with the at least a portion of the second optical signal into a combined signal at an output from the mixing unit; and
at least one photodetector for detecting the combined signal.
The optical monitoring device is configured to apply a modulation signal to modulate at least one of a phase of the portion of the first and/or second optical signal, a coupling of the portion of the first and/or second optical signal into the respective input, or an amplitude of the portion of the first and/or second optical signal being transferred into the combined signal.
The disclosure relates to a method for manufacturing a shape-retaining non-flat device (100), comprising: providing (S10) a flat device laminate (200) comprising: a first layer of thermoformable material (210); a carrier layer (230); conductive traces (240) arranged at least on a second portion (232) of the carrier layer (230); a circuit element (250) arranged on the second portion (232) and electrically connected to the conductive traces (240); deforming (S20) the device region (260) of the flat device laminate (200) into the shape-retaining non-flat device (100) by thermoforming (S22) the flat device laminate (200), wherein the carrier layer (230) is non-stretchable such that the respective shortest distance (d), along the second portion (232) of the carrier layer (230), between the circuit element (250) and a first portion (231), prior to and after the step of deforming (S20) the flat device laminate (200), are equal.
B29C 51/14 - Shaping by thermoforming, e.g. shaping sheets in matched moulds or by deep-drawingApparatus therefor using multilayered preforms or sheets
B29K 75/00 - Use of polyureas or polyurethanes as moulding material
B29L 31/34 - Electrical apparatus, e.g. sparking plugs or parts thereof
B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
A sampling circuit for sampling an analog input signal including: a capacitive means, a reset switch, and a sampling switch; the reset switch and the sampling switch being connected to a signal generator circuit configured to provide periodic reset and sampling control signals to the respective switches for controlling their operation. The respective periodic reset and sampling control signals have equal duty factors and signal periods, and a phase delay with respect to one another being less than the signals' duty factor, thereby forming an overlap period during which the reset switch and the sampling switch remain closed.
A computer-implemented method for tracking a communication device moving through an indoor environment; the method includes: i) obtaining channel impulse responses, CIRs, between the communication device and anchor devices along multiple propagation paths; ii) determining an a priori distribution of the location of the communication device within the environment; iii) determining from the channel impulse responses conditional distributions of the range-related measurements conditioned on a range between a potential location of the communication device within the a priori distribution and the respective anchor devices along respective line of sight, LoS, and first order propagation paths; and iv) estimating the location of the communication device as the potential location for which a combination of the a priori distribution and the conditional distributions is maximized.
H04W 4/029 - Location-based management or tracking services
G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using radio waves
RDH12RDH12 gene causes an upstream start codon (uATG) resulting in insufficient RDH12 protein production and hence causes inherited retinal disease. ASOs which hybridize with a region surrounding or containing said uATG provide steric hindrance for recognition of the upstream start codon, thus redirecting the scanning ribosomes to the primary start codon which results in increased RDH12 protein production.
INSTITUUT VOOR LANDBOUW-EN VISSERIJONDERZOEK (ILVO) (Belgium)
Inventor
Van Hautegem, Tom
Nelissen, Hilde
Inzé, Dirk
Claeys, Hannes Bart
Van Ex, Frédéric
Nuccio, Michael Lee
Ruttink, Tom
Abstract
The disclosure relates to maize plants with altered characteristics including tolerance to abiotic stress such as drought and/or increased water use efficiency, along with methods of using and making the same.
An optical antenna includes a waveguide structure having a waveguide core and a waveguide fin intersecting substantially under a right angle. A height of the waveguide fin is larger than a height of the waveguide core; and the width of the waveguide core is equal to or larger than twice a height of the waveguide core; and the height of the waveguide fin is equal to or larger than twice a width of the waveguide fin. The waveguide fin is off centered with respect to the waveguide core at an offset, thereby forming an optical antenna configured to leak radiation in a radiation direction. Embodiments relate to an optical phased antenna array comprising a plurality of such optical antennas arranged in an array configuration.
A photonic integrated circuit is provided for performing optical transient computing on an RF-modulated optical carrier signal. The photonic circuit includes at least two optical signal processing units, each including a filter device and a delay element for providing a delayed feedback signal to the filter device. The group delay induced by the delay element is in the range from 1 ps to 100 ps and the 3 dB bandwidth of the filter band is less than the inverse of the group delay. The delay element is adapted to spectrally align at least a portion of the filter band with a resonance in the feedback signal and center frequencies of filter bands are offset between 1 GHz and 100 GHz to allow filtering of different portions of the modulated carrier signal spectrum. The signal processing device has a trainable readout circuit.
G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
H04B 10/2575 - Radio-over-fibre, e.g. radio frequency signal modulated onto an optical carrier
44.
Cation-Independent Mannose-6-Phosphate Receptor Binders For Targeted Protein Degradation
The present invention relates to protein binding agents specifically binding the human cation-independent mannose-6-phosphate receptor (CI-M6PR), more specifically polypeptide agents comprising an immunoglobulin single variable domain (ISVD) specifically binding CI-M6PR at nano- to picomolar affinity, fused to further protein binding agents specifically binding extracellularly-accessible protein targets, such as membrane proteins, extracellular or secreted proteins. More specifically said CI-M6PR-specific ISVD recognizes CI-M6PR N-terminal domains 1, 2 and/or 3, thereby providing for means and methods for internalization, lysosomal targeting and degradation of agents comprising said ISVD, and of targets bound to said protein binding agents. The CI-M6PR binders disclosed herein are thus linked or fused to a further protein binding agent, in particular another antigen-binding protein, such as an ISVD or antibody, relevant for use in therapy, more specifically for treatment of diseases affected by said target antigen bound by said antigen-binding protein. More specifically disclosed herein are CI-M6PR ISVD fusions to antigen-binding proteins specifically binding EGFR, for treatment of cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
The present invention relates to novel fusion proteins, more specifically chimeric endolysins, and compositions comprising them. Furthermore, the invention relates to polynucleotides, such as nucleic acids and vectors encoding for said chimeric endolysins, as well as host cells comprising these polynucleotides. Also provided by the present invention is a pharmaceutical composition comprising an endolysin of the invention. Finally, the present invention relates to chimeric endolysins, polynucleotides (such as nucleic acid sequences, vectors), host cells, or compositions for use in medicine, in particular veterinary medicine, more in particular for the treatment and/or prevention of infections, in particular mammary gland infections, more in particular udder infections caused by Streptococci and/or Staphylococci.
The present invention relates to the field of methods to screen, diagnose or monitor treatment of disease. More in particular, the present invention discloses methods wherein an increased number of analytes demonstrating deviating amounts in a biofluid or tissue sample is used to determine whether an individual is diseased.
The present invention relates to a sealing strip for sealing joints between the surfaces of two adjacent components. The sealing strip comprises a main body defining a drainage structure that forms a drainage cavity when provided between the surfaces of the two adjacent components. The drainage structure comprises a top drainage layer having one or more top recesses extending downward in the top surface of the body, wherein each top recess is in fluid communication with a drainage opening in the front surface of the body. Moreover, none of the top recesses are in fluid communication with a drainage opening in the back surface of the body if any. The present invention further relates to a method for sealing joints between the surfaces of two adjacent components.
The present invention relates to the field of plant molecular biology, more particularly to the field of agriculture, even more particularly to the field of improving the yield of plants. The present invention provides chimeric genes and constructs which can be used to enhance the yield in plants and crops.
The present invention relates to the field of markers to predict the response of treatment of disease. Indeed, the present invention discloses that the amounts of a specific subset of NK cells –i.e. HLADR+CD56dimCD16+ NK cells- in blood samples taken from inflammatory bowel disease (IBD) patients who do not respond to treatment with a biologic medicine are significantly higher than the amounts which are found in responders to the same treatment. Hence the present invention relates to usages of said specific subset of natural killer (NK) cells to predict the (lack of) response by IBD patients to treatment with biologic medicines and/or to methods to predict the (lack of) response of said treatment.
The present invention relates to the field of glycoproteomics for identifying novel cell surface O-linked glycopeptide epitopes. The invention relates to methods for identifying O-linked glycopeptides, more specifically Tn- or SiaTn-antigen O-glycosylation sites on cell surface proteins, said method comprising a combined workflow of enzymatic treatments of cells or tissue samples to allow specific enrichment and labelling of Tn antigens, followed by mapping of the O-glycopeptides through LC-MS/MS. More specifically, the invention relates to a chemo-enzymatic method to produce labelled O-glycan-peptides from a plasmamembrane-protein extract sample, wherein Sialyltransferase (ST3Gal1/ST3Gal3) treatment is used to protect free galactose against a follow-on treatment with Galactose oxidase, wherein the oxidized glycans are simultaneously labelled. The invention further relates to a tandem mass spectrometry method using an enriched TMT-labelled (Sia)Tn-antigen glycopeptides in a dual fragmentation triggered approach to resolve the identity, localisation and quantification of the O-linked glycan peptides.
The present invention relates to the field of agriculture, even more particularly to the field of increasing the root length and root biomass of plants including also hairy root biomass. The present invention provides chimeric genes and constructs which can be used to increase the root size of crops, to increase the yield of crops and to increase the biomass of hairy roots.
The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions, such as wounds. The invention provides topical plasters and wound healing compositions. Specifically, the invention provides hydrogels compositions of glycyrrhizinic acid analogues. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
Capnocytophaga canimorsusCapnocytophaga canimorsusCapnocytophaga canimorsus GH29 enzyme. The invention further specifies methods and uses of said enzymes and compositions for production of defucosylated Fc-containing proteins and their therapeutic utility.
The present invention relates to the field of plant genetic engineering, particularly the modulation of gene expression in plant cells for improved regeneration competence. The invention discloses means and methods wherein the Ethylene Response Factor (ERF) and Phytochrome A Signal Transduction 1 (PAT1) transcription factor complex activity in plant cells grants increased regeneration.
A system for sensing diaper content includes a diaper, an outer coupling layer and a sensing circuitry. The diaper has a circuitry layer having inner input capacitor plates, tracks arranged to provide a resistive coupling between the inner capacitor plates dependent on the content, and inner output capacitor plates in galvanic contact with the respective inner input capacitor plates. The outer coupling layer contains outer input—and output capacitor plates arranged to form respective input—and output capacitors with the inner input—and output capacitor plates in the diaper when the outer coupling layer is provided onto the outside of the diaper. The sensing circuitry is arranged to apply an input signal onto the outer input capacitor plates, and to measure an output signal from the outer output capacitor plates resulting from the input signal and the resistive coupling thereby sensing the content.
A61F 13/42 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators with wetness indicator or alarm
57.
Environmental-friendly Process for the Treatment of Wastewater
Provided is a process for the environmental-friendly treatment of sulfate-containing wastewater. The acidic, sulfate-containing wastewater is treated in a sulfate reducing bioreactor with influent and effluent looped through to the cathode compartment of an electrochemical cell. The electrochemical cell stabilizes the pH in the bioreactor by the in-situ production of base in the cathode compartment. Additionally, hydrogen is produced which is used in the bioreactor as electron donor for the sulfate reduction. The middle compartment of the electrochemical cell contains a sulfide rich aqueous solution in which the extracted cations are displaced by protons from the anode compartment. This results in the acidification of the sulfide rich solution, which is beneficial for the extraction of sulfides as H2S. This H2S can be used for the precipitation of metals in the beginning of the process, forming another loop.
C02F 103/10 - Nature of the water, waste water, sewage or sludge to be treated from quarries or from mining activities
C02F 103/16 - Nature of the water, waste water, sewage or sludge to be treated from metallurgical processes, i.e. from the production, refining or treatment of metals, e.g. galvanic wastes
The present invention relates to the field of bioresorbable crosslinked materials. More specifically, the present invention pertains to a combination comprising a polyester having a crystalline backbone and at least one end-capping group attached to a first crosslinkable group and a compound comprising a second crosslinkable group, a crosslinked polyester wherein said combination forms a crosslinked network, a process of manufacturing thereof and the use of said crosslinked polyester.
The present invention relates to the field of medicine, in particular to internal and aesthetic regenerative medicine. More specifically, the present invention relates to a composition suitable for use as a transport medium for adipose tissue and/or cells derived thereof. The invention further relates to a liposuction infiltration formulation and a process to obtain lipoaspirate material.
The present invention relates to an aerosol composition comprising a UPy-PEG polymer and a pharmaceutically acceptable carrier for use in a method of treatment or prevention of a disease of the peritoneal cavity, wherein the treatment comprises administration of the aerosol composition to the peritoneal cavity by nebulization. The invention also relates to a drug nebulizing device for such use.
A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
PhascolarctobacteriumVeillonellaEubacteriumAgathobacterLactiplantibacillusAnaerostipesAnaerostipes. Aspects and embodiments described herein may be used in the treatment of joint inflammation, symptoms thereof, and underlying diseases and conditions.
A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 31/635 - Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide having a heterocyclic ring, e.g. sulfadiazine
The present invention relates to a structure comprising a first material, a second material and a coupling agent capable of coupling the first and the second material, the coupling agent comprising a moiety of formula (I) having a first nitrogen atom N' and a second nitrogen atom N"(formula (I)) with A comprising a chain of 2 to 4 carbon atoms, with said chain comprising a saturated linear chain or with at least 2 carbon atoms of said chain being part of a non-aromatic cyclic structure; with the first nitrogen N' being provided with a substituent L being capable of covalently binding with the first material, and with the moiety of formula (I) forming a covalent dynamic bond by means of the second nitrogen N" with the second material. The invention further relates to a method to provide such structure.
C08G 69/26 - Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
C08G 69/40 - Polyamides containing oxygen in the form of ether groups
63.
COMPOUNDS FOR INCREASING FROST TOLERANCE IN PLANTS
The present invention provides novel agrochemicals and formulations thereof and the use of these agrochemical formulations for providing abiotic stress tolerance, such as cold and frost tolerance, in plants.
A01N 43/38 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
A01N 47/30 - Derivatives containing the group N—CO—N—aryl or N—CS—N—aryl
A01N 43/707 - 1,2,3- or 1,2,4-TriazinesHydrogenated 1,2,3- or 1,2,4-triazines
DUTCH INNOVATION IN AIR TREATMENT B.V. (Netherlands)
UNIVERSITEIT GENT (Belgium)
Inventor
Hoogenboom, Richard
De Clerck, Karen
Becelaere, Jana
Schoolaert, Ella
Abstract
The present invention relates to a process to remove water from a gas by contacting the gas with a desiccant comprising nanofibers of a cross-linked hydrophilic polymer. wherein the cross-linked hydrophilic polymer is selected from the list comprising: Poly(2- alkyl-2-oxazoline) (PEOx), Poly(acrylic acid) (PAA), Polyethylene glycol (PEG), Polyhydroxyethylmethacrylate (PHEMA), Poly(N-vinyl imidazole) (PVIM), Poly[2 (Dimethylamino)ethyl Methacrylate] (PDMAEMA), Polyvinylpyrrolidone (PVP), poly(vinyl alcohol) (PVA), pullulan, chitosan, keratine, gelatin, salts, derivatives and copolymers thereof.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 20/30 - Processes for preparing, regenerating or reactivating
B01D 53/28 - Selection of materials for use as drying agents
B01D 71/00 - Semi-permeable membranes for separation processes or apparatus characterised by the materialManufacturing processes specially adapted therefor
65.
GENERATING T CELL PRECURSORS VIA AGONIZING TUMOR NECROSIS FACTOR RECEPTOR 2
This disclosure relates to methods and systems for generating T cell precursors from hematopoietic stem and progenitor cells (HSPCs) in vitro. This disclosure discloses that—besides activation of the Notch signaling pathway—activation of tumor necrosis factor receptor 2 (TNFR2) present on the HSPCs is crucial to maximize the generation of T cell precursors. Hence, this disclosure relates to methods and systems, such as artificial thymic organoid systems, wherein agonists for TNFR2, such as transmembrane tumor necrosis factor (tmTNF), are used to maximally generate T cell precursors. The latter T cell precursors are useful for immune reconstitution due to transplantation or immunodeficiency disorders and may be used to generate off-the-shelf chimeric antigen receptor T cells or T cell receptor engineered T cells for immunotherapeutic purposes.
Compositions and binding agents specifically binding the Spike protein of Corona viruses via at least two different binding sites and potently neutralizing coronaviruses, in particular sarbecoviruses, such as SARS-COV-1 and SARS-COV-2. The compositions or agents specifically bind to epitopes of the Receptor binding domain (RBD) of the Spike protein wherein both epitopes are conserved over multiple clades of the sarbecoviruses, providing broadly neutralizing pan-specific antibody-based compositions, thereby reducing viral escape. Application and uses of these agents and compositions are disclosed.
This disclosure relates to the application of the enzyme fructosyl-amino acid oxidase (FAOD)—without the addition of proteases—in medical and cosmetical conditions that are characterized by the presence of advanced glycation end products (AGEs).
This disclosure relates to the application of the enzyme fructosyl-amino acid oxidase (FAOD)—without the addition of proteases—in medical and cosmetical conditions that are characterized by the presence of advanced glycation end products (AGEs).
More specifically, this disclosure relates to the treatment of eye diseases in humans or animals. AGEs accumulate in the aging eye causing presbyopia, cataract, dry eyes, age-related macular degeneration, glaucoma and diabetic retinopathy.
This disclosure relates to the application of the enzyme fructosyl-amino acid oxidase (FAOD)—without the addition of proteases—in medical and cosmetical conditions that are characterized by the presence of advanced glycation end products (AGEs).
More specifically, this disclosure relates to the treatment of eye diseases in humans or animals. AGEs accumulate in the aging eye causing presbyopia, cataract, dry eyes, age-related macular degeneration, glaucoma and diabetic retinopathy.
Hence, the disclosure relates to the application of FAOD in order to deglycate and inactivate the AGEs.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
A61K 31/7084 - Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
A61K 33/06 - Aluminium, calcium or magnesiumCompounds thereof
VON KARMAN INSTITUTE FOR FLUID DYNAMICS, IVZW (Belgium)
Inventor
Van Geem, Kevin
Verstraete, Tom
Prinsier, Johan
Bonheure, Mike
Abstract
According to an embodiment shock wave device (100, 200) is disclosed suitable for thermal heating a process fluid comprising an axially oriented inlet (101, 201 ) and outlet (102, 202), thereby defining along an axis an axially enclosed volume, the device having between the inlet (101, 201 ) and the outlet (102, 202) a stage comprising a first rotor (104, 206) comprising a first set of vanes distributed around the axis and configured to rotate in a first rotation direction; a second rotor (105, 207) comprising a second set of vanes distributed around the axis and configured to rotate in a second rotation direction opposite to the first rotation direction; a vaneless space; and whereby the stage is configured to force the process fluid to flow from the inlet (101, 201) to the outlet (102, 202) by rotating the first (104, 206) and the second rotor (105, 207).
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific and technological services, as well as research
and design services relating thereto; industrial analysis
and research services; design and development of computers
and software; scientific research services resulting in
better understanding a drug candidate consisting of
combining RNA sequencing and microscopy of disease-relevant
cell models.
70.
COLLOIDAL BULK NANOCRYSTAL LASER AND RELATED METHOD
The invention relates to a method of manufacturing an optically-pumped or electrically-pumped device (1) with feedback structure comprising the steps of: - providing a substrate (10); - providing at least one optical confinement layer (12) on top of the substrate and comprising one or more integrated optical structures (120); - forming a colloidal dispersion comprising bulk semiconductor nanocrystals and/or bulk hetero nanocrystals,, with bulk semiconductor nanocrystals being defined as semiconductor nanocrystals having linear optical properties as determined by the corresponding material composition; - providing the colloidal dispersion, thereby forming a semiconductor film (11) and forming the device (1). The invention further relates to an optically-pumped or electrically-pumped device (1) with feedback structure comprising a substrate (10), at least one optical confinement layer (12), and at least one semiconductor film (11).
H01S 5/10 - Construction or shape of the optical resonator
H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
H01S 5/30 - Structure or shape of the active regionMaterials used for the active region
H01S 5/02 - Structural details or components not essential to laser action
H01S 5/183 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only vertical cavities, e.g. vertical cavity surface-emitting lasers [VCSEL]
H01S 5/12 - Construction or shape of the optical resonator the resonator having a periodic structure, e.g. in distributed feedback [DFB] lasers
The present invention pertains to the field of tissue engineering and in particular to materials adapted to adhere to cells. More in particular, the present invention pertains to polymer comprising thiol-ene crosslinked networks exposing one or more cell-binding-motifs (CBMs) and combinations providing for said networks.
According to an aspect of the present inventive concept there is provided a textile device comprising: a first fabric comprising at least one electrically conductive wire; an electronic component, wherein the electronic component is fixated to the first fabric and wherein the at least one electrically conductive wire is electrically connected to the electronic component; wherein the textile device has a transition region at an area of the first fabric arranged laterally from the electronic component; wherein the textile device further comprises a strengthening element at the transition region, wherein the strengthening element comprises: a second fabric arranged around the first fabric; and a thermoplastic material arranged in relation to at least a first portion of the second fabric, wherein the thermoplastic material is arranged around the first fabric and fills a spacing between the first fabric and the second fabric at least in the first portion of the second fabric.
D03D 1/00 - Woven fabrics designed to make specified articles
D03D 15/533 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads antistaticWoven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads electrically conductive
D04B 1/24 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes specially adapted for knitting goods of particular configuration wearing apparel
D04B 21/20 - Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes specially adapted for knitting articles of particular configuration
The present invention is in the field of cardiac arrhythmia. In particular, the present invention relates to systems and methods for identifying ablation lines, which can then be used to correct cardiac arrhythmia.
A device for generating a plasma jet is disclosed. A nozzle of the device comprises an inner, middle and outer channel surrounding each other and electrically insulated from each other. The device is configured for flowing through the inner, middle and outer channel respectively a first ignitable gas, a monomer precursor and a second ignitable gas towards their respective exit openings. A high voltage electrode is arranged in the inner channel for generating a plasma from the first ignitable gas. The nozzle further comprises a nozzle cap enclosing a mixing volume after the exit openings of the inner, middle and outer channel. The nozzle cap is provided with an exit opening after the mixing volume, which exit opening is smaller than the exit opening of the outer channel.
The invention relates to the field of sustainable agriculture, more particularly to means and methods to protect crops against cold and chilling stress. The application provides three novel Flavobacterium strains that upon administration to plants, protect the plants against growth retardation induced by low temperatures.
A method is provided for designing an antenna comprising: i) determining dimensions of a fractional-mode, FM, air-filled, AF, antenna cavity, a FM-AF cavity, resonating around a target centre frequency characterized by a conductive ground cavity layer, a conductive top cavity layer, conductive cavity sidewalls between the top and ground cavity layer, and a side opening resulting from the fractional-mode; ii) adding a guard trace for shielding radiation from the side opening by adding sidewalls at a distance from the side opening; wherein the conductive top cavity layer is at least partially open over said distance thereby obtaining a radiating slot between the guard trace and the FM-AF cavity; wherein the FM-AF cavity and radiation slot forms an antenna cavity; iii) matching the impedance of the antenna cavity around the target centre frequency by adjusting the FM-AF and/or radiating slot dimensions within a maximum footprint.
A method to selectively permeabilize and/or fragmentize cells. A structure comprising a material and particles able to absorb electromagnetic radiation and cells are brought at close distance from each other. Part of the particles embedded in the structure are exposed to the free surface of the structure. The structure and, in particular, the particles in the structure are irradiated with electromagnetic radiation to selectively permeabilize and/or fragmentize the cells. Furthermore, the disclosure relates to a structure for use in a photothermal process to selectively permeabilize and/or fragmentize cells.
Example embodiments relate to a method for determining a mix proportion of an alkali activated concrete, AAC, mixture for a set of desired physical properties of the AAC, and for a dry bulk volume of one or more coarse aggregates and a fine aggregate per unit volume of AAC. The method comprises determining (202) a mix proportion of an alkali activated paste, AAR, mixture from the set of desired physical properties of the AAC based on a predetermined relationship (210) between the set of desired physical properties of the AAC and the mix proportion of the AAR mixture; wherein the AAR mixture comprises one or more precursors, one or more chemical compounds of an alkali activator, and water according to the determined mix proportion of the AAR. The method further comprises determining (203) masses (261, 262) of the respective one or more coarse aggregates per unit volume of AAC and a mass (263) of the fine aggregate per unit volume of AAC by packing (230, 240, 250) particles of the respective aggregates (231, 241, 251) within the dry bulk volume (234) according to a particle packing model. The method further comprises determining (204) a mass of the AAR mixture per unit volume of AAC to complete a remaining volume within the unit volume.
C04B 40/00 - Processes, in general, for influencing or modifying the properties of mortars, concrete or artificial stone compositions, e.g. their setting or hardening ability
Example embodiments describe an optical balanced homodyne receiver (300) comprising i) an optical mixing element (320) configured to convert a modulated optical input signal (311) into a pair of demodulated optical signals (321, 322); ii) an opto-electric conversion circuitry (330) configured to convert the pair of demodulated optical signals into a demodulated electrical current signal (331); iii) a transimpedance, Tl, amplifier (360) with capacitive feedback configured to convert the demodulated electrical current signal to a demodulated electrical voltage signal (361 ); iv) a DC current cancellation circuitry (380) configured to measure a low frequency current component in the demodulated electrical current signal and to derive therefrom a feedback signal (381 ); and wherein the optical mixing element is tuneable (323) and configured to receive the feedback signal (381) and to adapt an optical power balance between the pair of demodulated optical signals based on the feedback signal such that the low frequency current component is suppressed.
Example embodiments relate to a computer-implemented method (200) for determining one or more physical properties of alkali activated concrete, AAC, from a mix proportion (201) of an AAC mixture. The AAC mixture comprises one or more precursors, one or more chemical compounds, and water according to the mix proportion. The computer implemented method comprises obtaining (210) one or more control factors (211 - 215) from the mix proportion of the AAC mixture, wherein the one or more control factors are indicative for one or more reaction mechanisms in the AAC mixture; and determining (220) a compressive strength (225) of the AAC based on the one or more control factors of the AAC mixture by means of a machine learning model (224). The machine learning model is trained by a training dataset (221) comprising one or more control factors of a plurality of AAC mixtures characterized by different mix proportions; and corresponding compressive strengths of the AAC obtained by setting and hardening of the respective AAC mixtures.
G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
81.
SILVER CONTAINING CROSSLINKED POLYMERS AS ADMIXTURE IN CEMENTITIOUS COMPOSITIONS
The present invention relates to a cementitious composition comprising one or more cementitious material(s); and a silver-containing, crosslinked polymer, wherein the crosslinked polymer is a covalently crosslinked polymer, and preferably wherein said silver-containing, crosslinked polymer comprises -A ⊝Ag ⊕groups; wherein A ⊝ is an anion, preferably a carboxylate anion or a sulphonate anion. The present invention further relates to a silver-containing covalently crosslinked polymer, as comprised in said cementitious composition, and various uses of such compositions and polymers for preparing concrete materials with improved properties or for coating concrete structures.
C04B 24/26 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
C04B 24/38 - Polysaccharides or derivatives thereof
C04B 28/02 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific and technological services, as well as research and design services relating thereto; industrial analysis and research services; design and development of computers and software; scientific research services resulting in better understanding a drug candidate consisting of combining RNA sequencing and microscopy of disease-relevant cell models.
The present invention is related to the field of intracellular delivery of membrane-impermeable materials. It provides compositions enabling the delivery of such membrane-impermeable materials into cells, applicable for both in vitro, in vivo and ex vivo delivery applications, as well as the use thereof in methods of cytosolic delivery of membrane-impermeable materials. The compositions and methods are particularly useful in biological research, diagnostic methods and the development of cell-based therapies.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
The present invention is generally related to a method and system for droplet manipulation and more specifically to a method and system for droplet manipulation using electrowetting technology. The methods and systems herein described are of particular interest for analyzing cell to cell interactions, more particularly for screening for immune cell-mediated cell lysis of tumor cells.
According to an aspect of the present inventive concept there is provided a photonic integrated circuit, PIC, comprising a waveguide array. Each waveguide is configured to guide a light signal. All guided light signals originate from a common light beam or multiple mutually coherent light beams.
According to an aspect of the present inventive concept there is provided a photonic integrated circuit, PIC, comprising a waveguide array. Each waveguide is configured to guide a light signal. All guided light signals originate from a common light beam or multiple mutually coherent light beams.
Each waveguide is associated with a mutually unique modulator, providing modulation, by a modulation signal, of phase and/or amplitude of the light signal, forming a modulated light signal. The modulation signals of all modulators have a common modulation period, such that the modulated light signal comprises a plurality of sideband frequencies representing different orders of frequency shifts based on harmonics of the modulation period.
According to an aspect of the present inventive concept there is provided a photonic integrated circuit, PIC, comprising a waveguide array. Each waveguide is configured to guide a light signal. All guided light signals originate from a common light beam or multiple mutually coherent light beams.
Each waveguide is associated with a mutually unique modulator, providing modulation, by a modulation signal, of phase and/or amplitude of the light signal, forming a modulated light signal. The modulation signals of all modulators have a common modulation period, such that the modulated light signal comprises a plurality of sideband frequencies representing different orders of frequency shifts based on harmonics of the modulation period.
A free propagation unit comprising inputs associated with the waveguides receives the modulated light signals. The modulated light signals propagate freely in two spatial dimensions through the free propagation unit and interfere to form output signals. Different outputs of the free propagation unit receive light with different peak frequency corresponding to different sideband frequencies.
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.
A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
Example embodiments relate to an electro-optical component. One embodiment includes an electro-optical component for adaptive visual correction. The component includes a first transparent substrate. The component also includes a second transparent substrate. Additionally, the component includes an optical structure disposed on the first transparent substrate. Further, the component includes a liquid-crystal gap located between the optical structure and the second transparent substrate. Even further, the component includes a first transparent electrode and a second transparent electrode located on opposite sides of the liquid-crystal gap. Still further, the component includes a plurality of spacers located in the liquid-crystal gap between the second transparent substrate and the optical structure. The plurality of spacers includes at least one spacer having a different height than another spacer of the plurality of spacers.
The present invention relates to a recombinant activation-associated secreted protein (ASP) or fragment thereof, said ASP or fragment comprising an N-glycan comprising a core α1,3-fucose and/or a core α1,6-fucose (Fuc). The invention further relates to a pharmaceutical composition comprising such a recombinant ASP or fragment thereof. Additionally, the invention relates to the recombinant ASP or fragment thereof for use as a human or veterinary medicine, in particular as a vaccine, more in particular for use against parasitic nematode infections.
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
The present invention relates to a method to treat compressed soils by physical soil amelioration using a rotary drilling system. Said rotary drilling system comprising a drilling tool with a compressed air passage extending between an inlet connection and at least one laterally directed outlet opening and configured for drilling responsive to rotation in a rotational direction about the longitudinal axis of the drilling tool; means for rotating the drilling tool in the rotational direction about the longitudinal axis of the drilling tool; and means for supplying compressed air to the inlet connection. Said method comprising the step of discharging compressed air into a surrounding medium via the at least one laterally directed outlet opening while simultaneously lowering and rotating the drilling tool. The present invention further relates to tools, machines and vehicles to execute such a method.
The present invention relates to a method for the manufacturing of an amidated polymer from a polymer comprising at least one side-chain comprising an ester moiety, a hydrogel obtained from crosslinking said amidated polymer and uses thereof.
C08F 8/32 - Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
C08F 8/30 - Introducing nitrogen atoms or nitrogen-containing groups
The invention relates to antigen-binding protein agents specifically binding the hemagglutinin- neuraminidase (HN) protein of human parainfluenza virus 3 (hPIV-3), with cross-reactivity for Sendai Virus (SeV) as well as human parainfluenza virus serotype 1 (hPIV-1) HN, resulting in a cross-neutralizing binding protein to act as a protection agent against parainfluenza infection and/or disease caused by such an infection. More specifically, the invention relates to a family of immunoglobulin single variable domains (ISVDs) capable of broadly blocking HN neuraminidase activity, thereby providing for a novel hPIV-1/-3 cross-neutralizing antiviral protein binding agent. The invention further relates to the use of said antigen-binding proteins in prevention or treatment of acute respiratory tract infections, croup, pneumonia, and exacerbations of chronic obstructive pulmonary disease.
Agents that bind to sarbecoviruses of multiple clades, neutralizing sarbecovirus infection, in particular neutralizing SARS-CoV-1 and SARS-CoV-2 infection. The agents bind to a unique epitope of the sarbecovirus ACE2-receptor binding domain (RBD) but do not inhibit binding of ACE2 with the RBD. Applications and uses of these agents are further disclosed.
A METHOD TO PREPARE A PRECURSOR FOR A POLYMER OR TO PREPARE A POLYMER COMPRISING AT LEAST ONE UNIT HAVING A TERTIARY AMINE AND A PENDANT CARBOXYL GROUP AND A PRECURSOR OR POLYMER COMPRISING SUCH UNIT
The invention relates to a method to prepare a precursor for a polymer or to prepare a polymer, the polymer comprising at least one unit of formula (I) or at least one unit of formula (II) having a tertiary amine and a pendant carboxyl group
The invention relates to a method to prepare a precursor for a polymer or to prepare a polymer, the polymer comprising at least one unit of formula (I) or at least one unit of formula (II) having a tertiary amine and a pendant carboxyl group
The invention relates to a method to prepare a precursor for a polymer or to prepare a polymer, the polymer comprising at least one unit of formula (I) or at least one unit of formula (II) having a tertiary amine and a pendant carboxyl group
Furthermore the invention relates to a precursor or polymer comprising at least one unit of formula (I) and/or at least one unit of formula (II) and to the use of such precursor or such polymer in extrusion, injection moulding, compression moulding, transfer moulding, foam moulding, thermoforming, rotation moulding or 3D printing
The present disclosure relates to an optical alignment compensation system for a gas detection system, in particular, to an integrated alignment compensation system for an open-path gas sensing system. The optical alignment compensation system of the disclosure is able to compensate for unwanted drifts of a retroreflector. The optical alignment system comprises an array of transceiver pairs, wherein each transceiver pair is configured to transmit and receive light with an optical spectrum in an absorption region of a gas to be detected. Further, it comprises a retroreflector arranged at a nominal position and configured to reflect the light. Further, it comprises an optical element arranged and configured to direct the light from at least one of the transceiver pairs along an optical path through the gas to the retroreflector, to receive the light reflected by the retroreflector along the optical path, and to direct the reflected light to the respective transceiver pair. Further, it comprises a control unit configured to select one of the transceiver pairs for transmitting and receiving the light, wherein the control unit is configured to select the transceiver pair that receives the reflected light with the highest signal response.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
95.
MEANS AND METHODS TO PRODUCE TRITERPENE SAPONINS IN EUKARYOTIC CELLS
The present invention provides novel chimeric genes for the production of quillaic acid and derivatives thereof in eukaryotic cells such as yeasts and plants.
Catheter for delivery of therapeutic liquid formulation Provided is a catheter (100) having a proximal end (10) and a distal end (12) for distribution of a liquid outflow, the catheter (100) comprising. First (120) and second (140) lumens are comprised in a tube (160) wherein a lumen (162) of the tube is partitioned into the first (120) and second (140) lumens by a partitioning wall (150) attached to the tube lumen wall (164), the outlets (122a to c) of the plurality on the distal (12) side of the distribution inlet (110) are longitudinally positioned and sized in mirrored symmetry with the plurality of outlets (122d to f) on the proximal (10) side of the distribution inlet (110). The plurality of outlets (122a to f) is configured to counteract a reduction in outflow as the distance from the distribution inlet (110) increases in the longitudinal direction (L).
A method for forming a device coupon (100) comprising the steps of: − providing a source wafer (1) comprising: − a source substrate (10); − a sacrificial layer (11); and − a film (12); − forming at least one device coupon (100) in said film (12); − designing one or more designed breakable tethers to secure said device coupon (100) to said film (12); − etching one or more recesses (111) extending through said device coupon (100), thereby exposing said sacrificial layer (11); − etching said sacrificial layer (11) away at least partially through one or more of said recesses (111), thereby forming one or more sacrificial recesses (121) in said sacrificial layer (11); and − filling at least some pairs of recesses (111) and sacrificial recesses (121) with a support material (200), thereby forming support structures (220) for said device coupon (100).
H01L 21/78 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in, or on, a common substrate with subsequent division of the substrate into plural individual devices
H01L 21/98 - Assembly of devices consisting of solid state components formed in or on a common substrateAssembly of integrated circuit devices
98.
A METHOD TO PREPARE POCKETS OF ENCAPSULATED MATERIAL COMPRISING A CORE SURROUNDED BY AN ENCAPSULATION
The invention relates to a method to prepare pockets comprising encapsulated material. The pockets are formed by first forming one or more bases B of barrier material on a substrate, by subsequently applying core material on at least part of the bases B and by forming a lid L on bases B provided with core material. The core material comprises at least one photoemissive particle or photoemissive compound such as quantum dots. The invention also relates to a pocket or a plurality of pockets comprising encapsulated material obtained by such method, to a device comprising at least one pocket of encapsulating material and to a process to transfer such a pocket of encapsulated material from one substrate to another substrate.
Fibrous materials are provided that comprise a cross-linkable urethane-based polymer (CUP) and an oligomeric or macromonomeric urethane-based cross-linker. The fibrous materials may be used in hydrogels, in filtration devices, in affinity membranes, in (protective) clothing, in drug delivery systems, and in tissue scaffolds, for example. The fibrous materials are useable also in human and/or veterinary medicine, such as in skin care and/or wound care.
D01F 6/70 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyurethanes
The present invention generally relates to the field of ionizable (also termed cationic) lipids, and in particular provides a novel type of such lipids as represented by formula (I). The present invention further provides methods for making such lipids as well as uses thereof, in particular in the preparation of nanoparticle compositions, more in particular nanoparticle compositions comprising nucleic acids. It further provides vaccine formulations comprising nanoparticle compositions based on the ionizable lipids disclosed herein.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
C07C 271/20 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
