A method for controlling fiber cross-alignment in a nanofiber membrane, comprising: providing a multiple segment collector in an electrospinning device including a first and second segment electrically isolated from an intermediate segment positioned between the first and second segment, collectively presenting a cylindrical structure, rotating the cylindrical structure around a longitudinal axis proximate to an electrically charged fiber emitter; electrically grounding or charging edge conductors circumferentially resident on the first and second segment, maintaining intermediate collector electrically neutral; dispensing electrospun fiber toward the collector, the fiber attaching to edge conductors and spanning the separation space between edge conductors; attracting electrospun fiber attached to the edge conductors to the surface of the cylindrical structure, forming a first fiber layer; increasing or decreasing rotation speed of the cylindrical structure to alter the angular cross-alignment relationship between aligned nanofibers in adjacent layers, the rotation speed being altered to achieve a target relational angle.
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A method for controlling fiber cross-alignment in a nanofiber membrane, comprising: providing a multiple segment collector in an electrospinning device including a first and second segment electrically isolated from an intermediate segment positioned between the first and second segment, collectively presenting a cylindrical structure, rotating the cylindrical structure around a longitudinal axis proximate to an electrically charged fiber emitter; electrically grounding or charging edge conductors circumferentially resident on the first and second segment, maintaining intermediate collector electrically neutral; dispensing electrospun fiber toward the collector, the fiber attaching to edge conductors and spanning the separation space between edge conductors; attracting electrospun fiber attached to the edge conductors to the surface of the cylindrical structure, forming a first fiber layer; increasing or decreasing rotation speed of the cylindrical structure to alter the angular cross-alignment relationship between aligned nanofibers in adjacent layers, the rotation speed being altered to achieve a target relational angle.
D01D 5/00 - Formation of filaments, threads, or the like
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B05B 5/053 - Arrangements for supplying power, e.g. charging power
B05B 5/08 - Plant for applying liquids or other fluent materials to objects
B05B 5/14 - Plant for applying liquids or other fluent materials to objects specially adapted for coating continuously moving elongated bodies, e.g. wires, strips, pipes
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
B32B 5/12 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments characterised by the relative arrangement of fibres or filaments of adjacent layers
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D04H 1/413 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties containing granules other than absorbent substances
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
3.
METAMATERIAL LAMINATE BASED ON POLYMER NANOFIBERS AND METALLIC NANOFIBERS AND METALLIC NANOPARTICLES FOR SENSOR APPLICATIONS
A metamaterial laminate having at least the following elements (a) at least one polymer nanofiber mesh having polymer nanofibers embedded with conductive nanoparticles, and (b) at least two films, wherein the polymer nanofiber mesh is sandwiched between the two films. Included are methods of making the laminate. A method to produce cross-direction and multilayers of multi-material nanofibrous polymer using an electrospun technique is presented. The laminate can be used in a method where it is incorporated in a structure and provides stress information by scanning with an electromagnetic radiation to determine physical change within the structure. The nanofiber polymer provides electric conductivity information detected by electrochemical analyzer.
B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
A metamaterial laminate having at least the following elements (a) at least one polymer nanofiber mesh having polymer nanofibers embedded with conductive nanoparticles, and (b) at least two films, wherein the polymer nanofiber mesh is sandwiched between the two films. Included are methods of making the laminate. A method to produce cross-direction and multilayers of multi -material nanofibrous polymer using an electrospun technique is presented. The laminate can be used in a method where it is incorporated in a structure and provides stress information by scanning with an electromagnetic radiation to determine physical change within the structure. The nanofiber polymer provides electric conductivity information detected by electrochemical analyzer.
B32B 17/02 - Layered products essentially comprising sheet glass, or fibres of glass, slag or the like in the form of fibres or filaments
B32B 33/00 - Layered products characterised by particular properties or particular surface features, e.g. particular surface coatingsLayered products designed for particular purposes not covered by another single class
B32B 27/02 - Layered products essentially comprising synthetic resin in the form of fibres or filaments
H01Q 17/00 - Devices for absorbing waves radiated from an antenna Combinations of such devices with active antenna elements or systems
H05K 9/00 - Screening of apparatus or components against electric or magnetic fields
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
5.
NON-BRAIDED BIODEGRABLE FLOW DIVERTING DEVICE FOR ENDOVASCULAR TREATMENT OF ANEURYSM AND ASSOCIATED FABRICATION METHOD
A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
B33Y 80/00 - Products made by additive manufacturing
B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B29C 64/393 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
A method for controlling fiber cross-alignment in a nanofiber membrane, comprising: providing a multiple segment collector in an electrospinning device including a first and second segment electrically isolated from an intermediate segment positioned between the first and second segment, collectively presenting a cylindrical structure, rotating the cylindrical structure around a longitudinal axis proximate to an electrically charged fiber emitter; electrically grounding or charging edge conductors circumferentially resident on the first and second segment, maintaining intermediate collector electrically neutral; dispensing electrospun fiber toward the collector, the fiber attaching to edge conductors and spanning the separation space between edge conductors; attracting electrospun fiber attached to the edge conductors to the surface of the cylindrical structure, forming a first fiber layer; increasing or decreasing rotation speed of the cylindrical structure to alter the angular cross-alignment relationship between aligned nanofibers in adjacent layers, the rotation speed being altered to achieve a target relational angle.
B32B 5/12 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments characterised by the relative arrangement of fibres or filaments of adjacent layers
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
D01D 5/00 - Formation of filaments, threads, or the like
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
B05B 5/053 - Arrangements for supplying power, e.g. charging power
B05B 5/14 - Plant for applying liquids or other fluent materials to objects specially adapted for coating continuously moving elongated bodies, e.g. wires, strips, pipes
B05B 5/08 - Plant for applying liquids or other fluent materials to objects
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
D04H 1/413 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties containing granules other than absorbent substances
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.
A method for controlling fiber cross-alignment in a nanofiber membrane, comprising: providing a multiple segment collector in an electrospinning device including a first and second segment electrically isolated from an intermediate segment positioned between the first and second segment, collectively presenting a cylindrical structure, rotating the cylindrical structure around a longitudinal axis proximate to an electrically charged fiber emitter; electrically grounding or charging edge conductors circumferentially resident on the first and second segment, maintaining intermediate collector electrically neutral; dispensing electrospun fiber toward the collector, the fiber attaching to edge conductors and spanning the separation space between edge conductors; attracting electrospun fiber attached to the edge conductors to the surface of the cylindrical structure, forming a first fiber layer; increasing or decreasing rotation speed of the cylindrical structure to alter the angular cross-alignment relationship between aligned nanofibers in adjacent layers, the rotation speed being altered to achieve a target relational angle.
D01D 5/00 - Formation of filaments, threads, or the like
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
B05B 5/053 - Arrangements for supplying power, e.g. charging power
B05B 5/14 - Plant for applying liquids or other fluent materials to objects specially adapted for coating continuously moving elongated bodies, e.g. wires, strips, pipes
B05B 5/08 - Plant for applying liquids or other fluent materials to objects
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
An assistive device for guiding performance of cardiopulmonary resuscitation (CPR) during cardiac arrest (CA), comprising an intelligent device and algorithm that present care givers realtime guidance and feedback on CPR quality using input from multiple invasive and noninvasive biometric monitoring devices. Input is combined and processed using artificial intelligence (AI) techniques to provide performance guidance displayed on a single monitor. Inputs include at least (a) heart rate, (b) end-tidal carbon dioxide—ETCO2, and (c) regional cerebral oxygen saturation—RSO2, which are processed to evaluate effectiveness of ongoing CPR and provide performance indicators in real time directed to increasing CPR effectiveness. Artificial intelligence functions evaluate effectiveness of CPR against standards of care as CPR is performed and provides actionable guidance to improve performance. Outputs are produced that include at least (a) performance parameters for compressions, (b) ventilation effectiveness, and (c) indication if return of spontaneous circulation (ROSC) has occurred.
A61H 31/00 - Artificial respiration by a force applied to the chestHeart stimulation, e.g. heart massage
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Apparatus for accumulating cross-aligned fiber in an electrospinning device, comprising a multiple segment collector including at least a first segment, a second segment, and an intermediate segment, the intermediate segment positioned between the first and second segment to collectively present an elongated cylindrical structure; at least one electrically chargeable edge conductor circumferentially resident on the first segment and circumferentially resident on the second segment; a connection point on the first segment and on the second segment, the connection points usable for mounting the elongated cylindrical structure on a drive unit to rotate around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent a charge or grounded.
D04H 3/04 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments in rectilinear paths, e.g. crossing at right angles
13.
Method and apparatus for fabricating a multifunction fiber membrane
A method and apparatus for fabricating multifunction membranes comprising cross-aligned nanofiber in an electrospinning device, the method comprising providing a multiple segment collector including at least a first segment, a second segment, and an intermediate segment to collectively present an elongated cylindrical structure; electrically charging an edge conductor circumferentially resident on the first segment and on the second segment; rotating the elongated cylindrical structure on a drive unit around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent a charge or grounded and a charged electrode is positioned opposite a fiber emitter; and repeating the process multiple times to form layers of nanofibers encapsulating agents of interest.
D01D 5/00 - Formation of filaments, threads, or the like
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
B05B 5/053 - Arrangements for supplying power, e.g. charging power
B05B 5/14 - Plant for applying liquids or other fluent materials to objects specially adapted for coating continuously moving elongated bodies, e.g. wires, strips, pipes
B05B 5/08 - Plant for applying liquids or other fluent materials to objects
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
14.
METHOD AND APPARATUS FOR ACCUMULATING CROSS-ALIGNED FIBER IN AN ELECTROSPINNING DEVICE
Apparatus for accumulating cross-aligned fiber in an electrospinning device, comprising a multiple segment collector including at least a first segment, a second segment, and an intermediate segment, the intermediate segment positioned between the first and second segment to collectively present an elongated cylindrical structure; at least one electrically chargeable edge conductor circumferentially resident on the first segment and circumferentially resident on the second segment; a connection point on the first segment and on the second segment, the connection points usable for mounting the elongated cylindrical structure on a drive unit to rotate around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent a charge or grounded.
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
D01D 5/00 - Formation of filaments, threads, or the like
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
D04H 1/736 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged characterised by the apparatus for arranging fibres
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
15.
Method and apparatus for accumulating cross-aligned fiber in an electrospinning device
An apparatus for accumulating cross-aligned fiber in an electrospinning device, comprising a multiple segment collector including at least a first segment, a second segment, and an intermediate segment, the intermediate segment positioned between the first and second segment to collectively present an elongated cylindrical structure; at least one electrically chargeable edge conductor circumferentially resident on the first segment and circumferentially resident on the second segment; a connection point on the first segment and on the second segment, the connection points usable for mounting the elongated cylindrical structure on a drive unit to rotate around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent a charge or grounded.
D01D 5/00 - Formation of filaments, threads, or the like
B05B 5/053 - Arrangements for supplying power, e.g. charging power
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
B05B 5/08 - Plant for applying liquids or other fluent materials to objects
B05B 5/14 - Plant for applying liquids or other fluent materials to objects specially adapted for coating continuously moving elongated bodies, e.g. wires, strips, pipes
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
16.
Method and apparatus for improving osseointegration, functional load, and overall strength of intraosseous implants
The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.
A system and method for detecting abnormal motor vehicle operation and providing notification and alerts to third parties, comprising: an impediment proximity detection subsystem including sensors at least mounted at external surfaces of said vehicle, said impediments consisting of at least fixed and moving objects external to said vehicle; a vital sign detection subsystem installed in said vehicle, including driver monitoring sensors and providing a measure of at least driver pulse rate and hand location; a controller installed in said vehicle, for receiving and processing sensor produced signals; an alarm subsystem installed in said vehicle, producing at least one of a visual or vibrational signal; a cloud interface subsystem including at least a WiFi transceiver installed in said vehicle, and a Google Cloud IoT Service or equivalent, and a vehicle to vehicle communication subsystem installed in said vehicle, using the BroadR-Reach® standard for automotive Ethernet or its evolving equivalents.
A61B 5/18 - Devices for psychotechnicsTesting reaction times for vehicle drivers
G07C 5/08 - Registering or indicating performance data other than driving, working, idle, or waiting time, with or without registering driving, working, idle, or waiting time
G07C 5/00 - Registering or indicating the working of vehicles
B60Q 9/00 - Arrangement or adaptation of signal devices not provided for in one of main groups
H04W 4/46 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for vehicle-to-vehicle communication [V2V]
An apparatus for accumulating cross-aligned fiber in an electrospinning device, comprising a multiple segment collector including at least a first segment, a second segment, and an intermediate segment, the intermediate segment positioned between the first and second segment to collectively present an elongated cylindrical structure; at least one electrically chargeable edge conductor circumferentially resident on the first segment and circumferentially resident on the second segment; a connection point on the first segment and on the second segment, the connection points usable for mounting the elongated cylindrical structure on a drive unit to rotate around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent a charge or grounded.
D01D 5/00 - Formation of filaments, threads, or the like
D04H 3/02 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of forming fleeces or layers, e.g. reorientation of yarns or filaments
B05C 19/02 - Apparatus specially adapted for applying particulate materials to surfaces using fluidised-bed technique
B05B 5/14 - Plant for applying liquids or other fluent materials to objects specially adapted for coating continuously moving elongated bodies, e.g. wires, strips, pipes
B05B 5/08 - Plant for applying liquids or other fluent materials to objects
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
B05B 5/053 - Arrangements for supplying power, e.g. charging power
19.
Method and apparatus for collecting cross-aligned fiber threads
An apparatus for collecting cross-aligned fiber threads, comprising an elongated assembly having a plurality of segments including at least a first segment, a second segment, and an intermediate segment, the first segment positioned at one end of the intermediate segment and the second segment positioned at an opposite end of the intermediate segment, each segment being electrically chargeable; an electrically chargeable emitter for electrospinning nanoscale fiber streams comprising charged fiber branches, the emitter having a tip positioned offset and between an edge of the first segment and an edge of the second segment; a support structure for rotating the elongated assembly about a longitudinal axis and applying an electrical charge to at least the edges of the first and second segment; at least one electrically chargeable steering electrode for attracting fiber streams, the at least one steering electrode chargeable with an electrical polarity opposing a charge applied to the emitter.
D01D 5/00 - Formation of filaments, threads, or the like
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
A system for guiding and evaluating physical positioning, orientation and motion of the human body, comprising: a cloud computing-based subsystem including an artificial neural network and spatial position analyzer said cloud computing-based subsystem adapted for data storage, management and analysis; at least one motion sensing device wearable on the human body, said at least one motion sensing device adapted to detect changes in at least one of spatial position, orientation, and rate of motion; a mobile subsystem running an application program (app) that controls said at least one motion sensing device, said mobile subsystem adapted to capture activity data quantifying said changes in at least one of spatial position, orientation, and rate of motion, said mobile subsystem further adapted to transfer said activity data to said cloud computing-based subsystem, wherein said cloud computing-based subsystem processes, stores, and analyzes said activity data.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
The present invention provides a process to functionalize nanofiber membrane (NFM) on a total joint replacement (TJR) implant surface to support bone ingrowth and reduce macrophage-associated inflammation, the process comprising amending the implant surface by laser cutting microgrooves greater than 100 μm in depth to protect functional PCL NFM from applied loading, induce a higher amount of osteoblast cell function, increase implant-bone contact area, and serve as a reservoir for the local delivery of biomolecules to increase osseointegration of the implant; depositing aligned fibers on the implant surface, the fibers aligned in the direction of the microgrooves and collected in layers until a thickness less than 30 μm is reached and preferably in the range of 1 μm to 10 μm. Biofunctionalized NFM are used to indirectly attach biomolecules on said implant surface, or extracellular matrix proteins with biomolecules are immobilized and deposited on the PCL NFM coated implant.
The present invention provides a method implementing a speech strategy based on zero crossing behavior of speech time waveforms; the zero crossing containing both spectral and temporal speech information. This method uses temporal information of speech to activate electrodes instead of spectral information; maps temporal segment durations to spatial durations along the basilar membrane inside the cochlea; and provides instantaneous, continuous information about speech to electrodes that stimulate the auditory nerve. Timing of oval window mechanical motion is represented by zero crossings which are used to activate electrodes implanted inside the cochlea. Motion of the tympanic membrane, and the oval and round windows, follow the speech signal temporal waveform. Positive segments of the temporal waveform cause inward displacement of the oval membrane from its stationary position and negative segments causes outward retraction of the membranes. Temporal waveform zero-crossings indicate time instants when the membranes are in their stationary positions.
The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.
The present invention implements a set of grooves/ridges created on Ti at the circumferential direction to increase surface area of implant in contact with bone. These grooves/ridges protect nanofiber matrix (NFM) made with Polycaprolactone (PCL) electrospun nanofiber (ENF) and collagen at the groove from physiological loading. Controlled fabrication of a ridge made with titanium nitride (TiN) around the circumference of Ti is provided using a plasma nitride deposition technique. PCL ENF may be deposited along the sub-micrometer grooves using the electrospin setup disclosed. The method provides for fabrication of microgroove on Ti using machining or TiN deposition and filling the microgrooves with the NFM. This method has proven through experimentation to be successful in increasing in vivo mechanical stability and promoting osseointegration on Ti implants. The immobilization of MgO NP and FN with the PCL-CG NFM on microgrooved Ti as provided in the invention optimizes biological performances of Ti.
The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.
The present invention provides processes for combined applications of making grooves on an implant surface, applying MgO nanoparticles with PMMA cement, restricting the cement movement by PCL nanofiber and tethering biomolecules with PCL nanofiber to enhance mechanical stability and osseointegration of PMMA cement with bone. This is achieved through enhanced osteoconductive properties, roughness, and less viable fracture originating sites at the bone-cement interface. Such combined applications of nanoparticle and nanofiber on the mechanical stability and osseointegration of cemented implant is heretofore unknown, but as provided by the present invention can solve the debonding problem of cemented implant from bone.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A method for coating a titanium (Ti) biomedical implant with nanofiber involves polishing a surface of the implant, amending the surface effecting at least one of grooves and ridges, exposing the surface to plasma O2, applying a collagen solution to the surface, producing electrospun nanofiber (ENF) made with at least Polycaprolactone (PCL) and depositing the ENF on the surface within the grooves and/or ridges. The ENF and collagen form a nanofiber matrix (NFM), and the NFM is adapted to bond within the grooves and/or ridges.
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/50 - Materials characterised by their function or physical properties
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
28.
Method and apparatus to coat a metal implant with electrospun nanofiber matrix
The present invention implements a set of grooves/ridges created on Ti at the circumferential direction to increase surface area of implant in contact with bone. These grooves/ridges protect nanofiber matrix (NFM) made with Polycaprolactone (PCL) electrospun nanofiber (ENF) and collagen at the groove from physiological loading. Controlled fabrication of a ridge made with titanium nitride (TiN) around the circumference of Ti is provided using a plasma nitride deposition technique. PCL ENF may be deposited along the sub-micrometer grooves using the electrospin setup disclosed. The method provides for fabrication of microgroove on Ti using machining or TiN deposition and filling the microgrooves with the NFM. This method has proven through experimentation to be successful in increasing in vivo mechanical stability and promoting osseointegration on Ti implants. The immobilization of MgO NP and FN with the PCL-CG NFM on microgrooved Ti as provided in the invention optimizes biological performances of Ti.
The invention implements a set of grooves/ridges created on Ti at circumferential direction to increase surface area of implant in contact with bone. These grooves/ridges protect nanofiber matrix (NFM) made with Polycaprolactone (PCL) electrospun nanofiber (ENF) and collagen at the groove from physiological loading. Controlled fabrication of a ridge made with titanium nitride (TiN) around the circumference of Ti is provided using a plasma nitride deposition technique. PCL ENF may be deposited along the sub-micrometer grooves using the electrospin setup. The method provides for fabrication of microgroove on Ti using machining or TiN deposition and filling the microgrooves with the NFM. This method has proven through experimentation to be successful in increasing in vivo mechanical stability and promoting osseointegration on Ti implants. The immobilization of MgO NP and FN with the PCL-CG NFM on microgrooved Ti as provided in the invention optimizes biological performances of Ti.
A process providing a method to create 3D scaffolds using nano-scale fibers, comprising: deposition and alignment of a plurality of electrospun fiber layers on a substrate; application of a photosensitive biomedical polymer liquid to each fiber layer deposited on said substrate; deposition and cross-alignment of a plurality of electrospun fiber layers on said substrate; retaining said polymer liquid in place using said cross-aligned fiber layers; curing said polymer liquid on top of each fiber layer using UV light.
D01H 4/28 - Open-end spinning machines or arrangements for imparting twist to independently moving fibres separated from sliversPiecing arrangements thereforCovering endless core threads with fibres by open-end spinning techniques using electrostatic fields
31.
Process to create 3D tissue scaffold using electrospun nanofiber matrix and photosensitive hydrogel
A process providing a method to create 3D scaffolds using nano-scale fibers, comprising: deposition and alignment of a plurality of electrospun fiber layers on a substrate; application of a photosensitive biomedical polymer liquid to each fiber layer deposited on said substrate; deposition and cross-alignment of a plurality of electrospun fiber layers on said substrate; retaining said polymer liquid in place using said cross-aligned fiber layers; curing said polymer liquid on top of each fiber layer using UV light.
D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
D01D 5/00 - Formation of filaments, threads, or the like
D06M 15/27 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated carboxylic acidsSalts or esters thereof of alkylpolyalkylene glycol esters of unsaturated carboxylic acids
D06M 23/14 - Processes for the fixation or treatment of textile materials in three-dimensional forms
D01F 6/62 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyesters
B29K 105/00 - Condition, form or state of moulded material
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educating at senior high schools; Educating at university or colleges; Educational services, namely, conducting classes, seminars, workshops, and continuing education courses in the field of education and professional development and distribution of course material in connection therewith; Providing continuing business education courses; Providing courses of instruction at the K-12 and college level; Education services, namely, providing kindergarten through 12th grade (K-12) classroom instruction
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, conducting classes, seminars, workshops, and continuing education courses in the fields of education and professional development and distribution of course material in connection therewith; Educational services, namely, providing web-based and classroom training for certification of teachers and corporate educators and continuing education for teachers and principals
34.
Device and a method for imaging-guided photothermal laser therapy for cancer treatment
This invention relates to a device and a method for monitoring and optimizing photothermal therapy, using a high-power continuous-wave laser beam and a pulsed laser beam, both transmitted through a single soft, multi-mode optical fiber with a diffuse active tip, to interstitially irradiate the target tissue at the same time. The continuous-wave laser light induces photothermal effect and increases tissue temperature and the pulsed laser light produces a photoacoustic signal. The photoacoustic signal intensity is used to monitor the temperature changes in the target tissue and to guide the irradiation of the high-power laser to optimize the photothermal effect by adjusting the light intensity and irradiation time.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
35.
ENGINEERED INTERVERTEBRAL DISC (IVD) FOR DEGENERATED DISC DISEASE
The present invention provides a process by which both non-tissue engineered and tissue engineered cartilaginous-like structures can be fabricated. The process of the present invention provides a method to produce electrospun nanofiber-anchored NP gels. The present invention provides a functional design for novel engineered IVD. The present invention provides a method for fabrication of both non-tissue and tissue engineered IVDs. These cartilaginous-like structures can be used to produce replacements for degenerated natural IVD. The method of the present invention uses electrospun PCL nanofiber mesh to anchor the NP. The method of the present invention can create angle-ply AF structure around the circumference of NP to mimic the architecture of native IVD. The method of the present invention anchors the top and bottom sides of NP by using non-woven aligned or random nanofiber mesh to create scaffold for the generation of endplate (EP) tissue.
The present invention provides a process by which both non-tissue engineered and tissue engineered cartilaginous-like structures can be fabricated. The process of the present invention provides a method to produce electrospun nanofiber-anchored NP gels. The present invention provides a functional design for novel engineered IVD. The present invention provides a method for fabrication of both non-tissue and tissue engineered IVDs. These cartilaginous-like structures can be used to produce replacements for degenerated natural IVD. The method of the present invention uses electrospun PCL nanofiber mesh to anchor the NP. The method of the present invention can create angle-ply AF structure around the circumference of NP to mimic the architecture of native IVD. The method of the present invention anchors the top and bottom sides of NP by using non-woven aligned or random nanofiber mesh to create scaffold for the generation of endplate (EP) tissue.
The present invention provides a process by which both non-tissue engineered and tissue engineered cartilaginous-like structures can be fabricated. The process of the present invention provides a method to produce electrospun nanofiber-anchored NP gels. The present invention provides a functional design for novel engineered IVD. The present invention provides a method for fabrication of both non-tissue and tissue engineered IVDs. These cartilaginous-like structures can be used to produce replacements for degenerated natural IVD. The method of the present invention uses electrospun PCL nanofiber mesh to anchor the NP. The method of the present invention can create angle-ply AF structure around the circumference of NP to mimic the architecture of native IVD. The method of the present invention anchors the top and bottom sides of NP by using non-woven aligned or random nanofiber mesh to create scaffold for the generation of endplate (EP) tissue.
A process providing a method for production of probiotic functional food products from plant substrates, the method comprising: activation of probiotic bacteria in an agar-agar formulation; formulation of water active plant substrates; culturing and incubation of water active plant substrates with activated probiotic bacteria; cooling and refrigeration.
A system for guiding and evaluating physical positioning, orientation and motion of the human body, comprising: a cloud computing-based subsystem including an artificial neural network and spatial position analyzer said cloud computing-based subsystem adapted for data storage, management and analysis; at least one motion sensing device wearable on the human body, said at least one motion sensing device adapted to detect changes in at least one of spatial position, orientation, and rate of motion; a mobile subsystem running an application program (app) that controls said at least one motion sensing device, said mobile subsystem adapted to capture activity data quantifying said changes in at least one of spatial position, orientation, and rate of motion, said mobile subsystem further adapted to transfer said activity data to said cloud computing-based subsystem, wherein said cloud computing-based subsystem processes, stores, and analyzes said activity data.
A61G 7/057 - Arrangements for preventing bed-sores or for supporting patients with burns, e.g. mattresses specially adapted therefor
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
40.
METHOD AND APPARATUS FOR CONTROLLED ALIGNMENT AND DEPOSITION OF BRANCHED ELECTROSPUN FIBER
A method for separating out nano-scale fiber threads from many fiber branches and controlling alignment and deposition of the fiber threads on a substrate, comprising: electrospinning at least synthetic polymer fiber streams from an electrically charged syringe needle; controlling the fiber using at least one electrically charged metallic disk rotating about an axis positioned below the needle; capturing the fiber using electrically grounded collector; extracting a single or plurality of fiber branch threads from the fiber streams, wherein the single or plurality of fiber branch threads is attracted to and intercepted by the collector shape, and depositing the single or plurality of fiber branch threads as substantially aligned fiber on the collector.
A method for separating out nano-scale fiber threads from many fiber branches and controlling alignment and deposition of the fiber threads on a substrate, comprising: electrospinning at least synthetic polymer fiber streams from an electrically charged syringe needle; controlling the fiber using at least one electrically charged metallic disk rotating about an axis positioned below the needle; capturing the fiber using electrically grounded collector; extracting a single or plurality of fiber branch threads from the fiber streams, wherein the single or plurality of fiber branch threads is attracted to and intercepted by the collector shape, and depositing the single or plurality of fiber branch threads as substantially aligned fiber on the collector.
A method for separating out a continuous single thread of fiber from many fiber branches and controlling alignment and deposition of said fiber on a substrate, comprising: electrospinning synthetic polymer fiber streams from an electrically charged syringe needle; controlling the fiber using at least one electrically charged metallic disk rotating about an axis positioned below the needle; capturing the fiber using electrically grounded collector; extracting a single fiber branch thread from the polymer fiber streams, wherein the single fiber branch thread is attracted to and intercepted by the collector shape, and depositing the single fiber branch thread as substantially aligned fiber on the collector.
A method and apparatus for providing personalized configuration of physical supports for the human body, comprising accepting input including an individual's demographic information, neurological attributes, physical history, operational environment, and outcome or use objectives, processing user input employing an artificial intelligence engine, and then returning guidance and/or control parameters directed to seating adjustment and positioning, including incline angles for wheelchair tilt and recline.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
G06N 3/10 - Interfaces, programming languages or software development kits, e.g. for simulating neural networks
A61G 7/057 - Arrangements for preventing bed-sores or for supporting patients with burns, e.g. mattresses specially adapted therefor
44.
Intelligent apparatus for providing personalized configuration of wheelchair tilt and recline
A method and apparatus for providing personalized configuration of physical supports for the human body, comprising accepting input including an individual's demographic information, neurological attributes, physical history, operational environment, and outcome or use objectives, processing user input employing an artificial intelligence engine, and then returning guidance and/or control parameters directed to seating adjustment and positioning, including incline angles for wheelchair tilt and recline.
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
G06E 1/00 - Devices for processing exclusively digital data
G06E 3/00 - Devices not provided for in group , e.g. for processing analogue or hybrid data
G06F 15/18 - in which a program is changed according to experience gained by the computer itself during a complete run; Learning machines (adaptive control systems G05B 13/00;artificial intelligence G06N)
G06G 7/00 - Devices in which the computing operation is performed by varying electric or magnetic quantities
G06F 17/00 - Digital computing or data processing equipment or methods, specially adapted for specific functions
A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic photophysical and immunological reactions for cancer treatment. To prepare the immunologically modified nanotubes, carbon nanotubes are dissolved in a solution of glycated chitosan, an immunostimulant, hence using glycated chitosan as a surfactant for rendering the aqueous solution of nanotubes stable. The compound can be used for treatment of cancer. The method includes steps of intratumorally administering immunologically modified nanotubes and administering laser irradiation of the target tumor. The nanotube serves as a carrier to deliver immunoadjuvants to the tumor cells and serves as a light-absorbing agent in a cell body of a tumor in a host. Upon laser irradiation of target tumor cells, immunologically modified nanotubes inside the tumor cells can produce spatially and temporally synchronized photothermal and immunological reactions for cancer treatment.
A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic photophysical and immunological reactions for cancer treatment. To prepare the immunologically modified nanotubes, carbon nanotubes are dissolved in a solution of glycated chitosan, an immunostimulant, hence using glycated chitosan as a surfactant for rendering the aqueous solution of nanotubes stable. The compound can be used for treatment of cancer. The method includes steps of intratumorally administering immunologically modified nanotubes and administering laser irradiation of the target tumor. The nanotube serves as a carrier to deliver immunoadjuvants to the tumor cells and serves as a light-absorbing agent in a cell body of a tumor in a host. Upon laser irradiation of target tumor cells, immunologically modified nanotubes inside the tumor cells can produce spatially and temporally synchronized photothermal and immunological reactions for cancer treatment.
A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic photophysical and immunological reactions for cancer treatment. To prepare the immunologically modified nanotubes, carbon nanotubes are dissolved in a solution of glycated chitosan, an immunostimulant, hence using glycated chitosan as a surfactant for rendering the aqueous solution of nanotubes stable. The compound can be used for treatment of cancer. The method includes steps of intratumorally administering immunologically modified nanotubes and administering laser irradiation of the target tumor. The nanotube serves as a carrier to deliver immunoadjuvants to the tumor cells and serves as a light-absorbing agent in a cell body of a tumor in a host. Upon laser irradiation of target tumor cells, immunologically modified nanotubes inside the tumor cells can produce spatially and temporally synchronized photothermal and immunological reactions for cancer treatment.
A01N 43/04 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom
A61N 5/067 - Radiation therapy using light using laser light
