Abstract

Provided is a method for compensating for loss in wave propagation, comprising: obtaining real frequency responses on the basis of a measurement result of wave propagation; selecting a complex frequency on the basis of the frequency of a wave and the dielectric constant of a medium so as to at least partially counteract the imaginary part of an in-plane wave vector in the wave propagation; and on the basis of a plurality of real frequency responses and the complex frequency, obtaining a complex frequency response to compensate for loss in the wave propagation.

IPC Classes  ?

• H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves

Abstract

The present invention relates to a welding assembly for packaging of a power semiconductor module. The welding assembly comprises: a first component, the outermost layer on a first side of the first component being a non-copper metal layer; a second component, a first copper layer being arranged on a first side of the second component; and a connecting copper layer, wherein two sides of the connecting copper layer are respectively connected to the non-copper metal layer and the first copper layer to form a first interface and a second interface, such that the first component and the second component are fixed together, and the average grain size of the connecting copper layer is in the range of 35-400 nm. The present invention further provides a welding assembly used for packaging of a semiconductor chip and relating to a plurality of components, and a method for producing the welding assembly for packaging of a power semiconductor module.

IPC Classes  ?

• H01L 23/492 - Bases or plates
• H01L 21/60 - Attaching leads or other conductive members, to be used for carrying current to or from the device in operation

Abstract

Described is a device for large-scale, high throughput, and rapid fabrication of microtissues. The device is designed as an invertible insert or a hanging insert, suitable for inversion and placement inside a single-compartment tissue culture plate. Further, the device has a three-dimensional support and contains a two-dimensional array of microwells with round-bottom cavities. The device facilitates the formation of multiple microtissues, including both cell aggregates and matrix-incorporated microtissues, through a single deposition process. Features of the device allow harvesting of microtissues via low-speed centrifugation.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C08J 5/18 - Manufacture of films or sheets
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof

Abstract

The purpose of the present disclosure is to perform communication and channel estimation by using a multi-functional signal in a wireless communication system. A method for operating a first device may include the steps of: transmitting a first signal having a non-coherent detectable structure; transmitting first configuration information related to sounding to a second device; receiving a second signal on the basis of the first configuration information; transmitting second configuration information related to channel estimation to the second device; and transmitting a third signal to the second device on the basis of the second configuration information. The second configuration information is based on an antenna position of the second device, the antenna position being estimated on the basis of the first signal and the second signal, and may include a range of at least one basis vector included in a dictionary.

IPC Classes  ?

• H04L 27/26 - Systems using multi-frequency codes
• H04L 25/02 - Baseband systems Details

Abstract

A method for scalable fabrication of ultraflat polycrystalline diamond membranes, comprising: (1) growing a polycrystalline diamond membrane on a growth substrate having diamond seeds on the surface thereof using a chemical vapour deposition method; (2) cutting off at least a portion of the substrate after growth, forming a boundary at the cut where the polycrystalline diamond membrane is bonded to the growth substrate; (3) sticking a peeling tape; and (4) pulling the peeling tape to peel the polycrystalline diamond membrane off the surface of the growth substrate to expose the nucleation surface of the polycrystalline diamond membrane, wherein the exposed nucleation surface has a roughness less than the roughness of the grown surface. By flipping the nucleation surface of the grown polycrystalline diamond membrane, develops a novel and facile approach for fabricating affordable, scalable, ultraflat and transferable polycrystalline diamond membranes with great potential for practical applications.

IPC Classes  ?

• C23C 16/27 - Diamond only
• C23C 16/02 - Pretreatment of the material to be coated
• C23C 16/511 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using microwave discharges

Abstract

The present invention is for estimating a near-field channel in a wireless communication system. This method for operating a terminal may comprise the steps of: receiving first configuration information related to sounding from a base station; transmitting a sounding signal on the basis of the first configuration information; receiving second configuration information related to channel estimation from the base station; receiving a downlink reference signal from the base station on the basis of the second configuration information; and performing the channel estimation on the basis of the downlink reference signal.

IPC Classes  ?

• H04W 24/08 - Testing using real traffic
• H04B 17/373 - Predicting channel quality parameters
• H04L 5/00 - Arrangements affording multiple use of the transmission path
• H04W 72/23 - Control channels or signalling for resource management in the downlink direction of a wireless link, i.e. towards a terminal
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04B 7/08 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the receiving station
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

An interfacial plasmonic heating intensified IP reaction (IPH-IP) is used to fabricate highly permeable and selective polyamide RO membranes. Silver nanoparticles (AgNPs) are introduced to the IP reaction interface to serve as nano-heat generators under light illumination. The coupling of generated nano-heat rapidly promotes the interfacial temperature, thereby boosting the formation of extensively “nano-foamed” polyamide with prominent nanovoids and high crosslinking degree. These features enable the resulting RO membrane to achieve a superior combination of water permeance (3.4 L m−2 h−1 bar−1) and NaCl rejection (99.7%). This outstanding separation performance further enables the membrane to efficiently remove a wide spectrum of toxic contaminants frequently found in different water sources, revealing huge potential for various water treatment applications. In addition, the resulting RO membrane demonstrates efficient desalination of real seawater, producing clean water with high quality that far exceeds those of benchmarking commercial membranes.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/14 - Dynamic membranes
• B01D 71/56 - Polyamides, e.g. polyester-amides

Abstract

The present disclosure is for acquiring channel information in a wireless communication system. An operation method of a terminal may comprise the steps of: receiving a first signal; generating information related to a channel by using the first signal; transmitting a second signal including feedback information related to the channel; and receiving a third signal transmitted on the basis of the feedback information. The feedback information includes information related to the distance between channel information and each portion of the first signal, and the first signal may have a structure supporting at least one operation among transferring information to another terminal and sensing an object.

IPC Classes  ?

• G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04B 7/0417 - Feedback systems
• G01S 7/292 - Extracting wanted echo-signals
• G01S 13/46 - Indirect determination of position data
• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications

Abstract

A method for enhancing characteristic signals by synthesizing multiple frequency waves is provided, which includes: obtaining real frequency responses based on the measurement results of spectral signals; selecting complex frequencies to at least partially compensate for spectral line broadening caused by losses; and obtaining complex frequency responses based on multiple real frequency responses and the selected complex frequencies to enhance the characteristic signals.

IPC Classes  ?

• H03L 7/16 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop

Abstract

A two-dimensional spectrum recording apparatus has a source of collimated laser light impinging on a sample on a plate. The light passing through the sample forms an object wave and the light not passing through the sample forming a reference wave, which interfere with each other to form a holographic image at the plate. A beam splitter receives the collimated laser light from the sample and forms separate first and second light beams. A linear polarizer receives the first beam and passes it to a polarization camera having a Full Stokes mask. The camera records the light that passes through the Stokes mask. A slit aperture receives the second beam and transforms it into a slit of light that is applied to a diffraction grating. A diode array receives the second beam from the diffraction grating and forms a light spectrum that is recorded.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties

Abstract

The purpose of the present disclosure is to generate a multi-functional signal in a wireless communication system. This method for operating a device may comprise the steps of: generating information bits; generating at least one codeword by encoding the information bits; generating at least one symbol corresponding to at least a part of the at least one codeword; and transmitting the at least one symbol.

IPC Classes  ?

• H04L 27/34 - Amplitude- and phase-modulated carrier systems, e.g. quadrature-amplitude modulated carrier systems
• H04L 27/38 - Demodulator circuitsReceiver circuits

Abstract

The subject invention pertains to a novel poly(diallyldimethylammonium) fluoride (PDDAF) compound that provides a restorative material to arrest dental caries, remineralize carious lesions, and inhibit bacterial growth.

IPC Classes  ?

• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 8/84 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds
• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

Disclosed are polymersome nanoparticles that comprise a combination of drugs: (i) a ubiquitin-proteasome system (UPS) inhibitor; and (ii) a macropinocytosis inhibitor. Also disclosed is a method of treatment of cancer using the nanoparticles. Disclosed is a method of treatment of tumor having nutrient-deprived microenvironment, such as deficient in amino acids. The disclosure is directed to a combination of drugs for starvation of tumor cells comprising the use of nanoparticles which inhibits degradation of proteins in the tumor cells and prevents internalization of proteins into the tumor cells. Also provided are compositions and methods for affecting cell proliferation, metabolism or sensitization, including proteasome inhibitor therapy for the treatment of disease caused by deregulation of ubiquitin-proteasome systems, in a cell or subject.

IPC Classes  ?

• A61K 31/69 - Boron compounds
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/4965 - Non-condensed pyrazines
• A61P 35/00 - Antineoplastic agents

Abstract

The T-cell receptor (TCR) plays a crucial role in the adaptive immune response by recognizing specific antigens. In the context of cancer immunotherapy, TCR sequences can be engineered to target specific tumor antigens. In this study, hepatocellular carcinoma (HCC) was modeled in mice by combining genetic alterations recurrently observed in the human disease, and identified HCC-specific TCRs using single-cell TCR-seq. TCR convergence was observed across HCC-bearing mice, indicating that TCRs specific for HCC antigens elicit the expansion of CD4+ T cells. To further elucidate the function of this HCC-specific TCR, TCR-expressing vectors were designed and built, which can be used for various in vitro and in vivo applications, including identifying the specific peptide sequence that the TCR recognizes, manufacturing TCR-engineered T cells, studying T cell function, and screening potential immunotherapies. The findings have important implications for the development of T cell-based cancer immunotherapies.

IPC Classes  ?

• C07K 14/725 - T-cell receptors
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

An electronic reader for electro-chemical transistors (OECT) includes a potential output control module that controls the Vd, Vs, and Vg for the OECT under test, a high accuracy current monitor module which contains a transimpedance amplifier (TIA) used to control the output voltage and convert the input channel current Ids into a voltage value. A microcontroller (MCU) that controls the working sequences of the TIA so as to realize the specific characterization mode and enable an adjustable output voltage range. The MCU further controls a programmable sampling rate of up to 200 k samples per second (SPS) with low noise by down-sampling the base rate, convolution processing it and interpolating it back to ah high frequency, but without the noise. The device is small enough to be worn by a user and its output is sent to a mobile device for reading.

IPC Classes  ?

• G08C 17/02 - Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
• G04G 21/04 - Input or output devices integrated in time-pieces using radio waves
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

The present invention provides a tensegrity joint comprising: a first inner structure having a first frame and a first strut extending orthogonally from the first frame; a second inner structure having a second frame and a second strut extending orthogonally from the second frame; at least three actuation tendons, each being fixed at a respective hole at the first frame and being guided and allowed to slide through a respective hole at the second frame; a central tendon connecting an apex of the first strut and an apex of the second strut such that the central tendon is in balance with the pulling forces exerted by the at least three actuation tendons; and an outer elastic protection sheath configured to wrap on a cylindrical surface between the first and second inner structures.

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/16 - Programme controls

Abstract

The present invention relates to the technical field of construction waste treatment. Provided is an on-site intelligent sorting method for construction waste. The method comprises: S10, identifying waste components, and quantifying the proportion of inert material in construction waste; S20, by means of a computer vision method, acquiring visual difference features between the inert material and non-inert material; S30, performing mechanical screening, wherein the construction waste is screened by means of a mechanical screening module; S40, on the basis of precise sorting by a robot, performing detection on waste on a conveyor belt by means of waste detection driven by machine vision, then performing waste positioning, and, according to the results of waste detection and positioning, performing accurate sorting by using multiple robotic arms. The advantages of the present invention comprises: the described method is suitable for compact construction site scenes, the required space for installation and deployment is small, and an intelligent solution is provided for construction waste classification at compact sites.

IPC Classes  ?

• B07C 5/34 - Sorting according to other particular properties
• B07C 5/02 - Measures preceding sorting, e.g. arranging articles in a stream, orientating
• B07C 5/36 - Sorting apparatus characterised by the means used for distribution
• B07B 1/08 - Screens rotating within their own plane
• B07B 9/00 - Combinations of apparatus for screening or sifting or for separating solids from solids using gas currentsGeneral arrangement of plant, e.g. flow sheets
• B03C 1/30 - Combinations with other devices, not otherwise provided for

Abstract

wastewasteinertnon-inertnon-inert; and S30, establishing a general linear equation. The beneficial effects of the present invention are as follows: a construction waste mixture conforming to a classification standard can be identified quickly and accurately at a low cost, and construction waste having low classification and recycling value is excluded, thereby reducing the time cost and mechanical cost, and improving the treatment efficiency of the construction waste.

IPC Classes  ?

• G06Q 10/063 - Operations research, analysis or management

Abstract

222, and wherein the iron-based metal complex has undergone a pulsed laser treatment for increasing catalytic surface area, number of catalytic sites and/or catalytic efficiency of the iron-based metal complex when compared with untreated iron-based metal complex before the pulsed laser treatment.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• C25B 1/30 - Peroxides
• C25B 1/50 - Processes

Abstract

Disclosed is an automated method for evaluating the ZP-binding capability of spermatozoa according to their morphological features in assisted reproduction using deep learning. Also provided is a method of predicting fertilization success in clinical assisted reproduction based on the ZP-binding capability of spermatozoa.

IPC Classes  ?

• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G06T 7/00 - Image analysis
• G06N 3/08 - Learning methods

Abstract

An ambient noise differential adjoint tomography system(l) is provided. The system(l) comprises seismic wave recording devices(101,102,103) and a processor) 100). The processor) 100) indicates three of the seismic wave recording devices(101,102,103) as a source(lOl), a first receiver) 102), and a second receiver) 103), and the source(lOl) and the first and second receivers (102, 103) are arranged as a linear array, and the first and second receivers(102,103) are positioned nearby each other. The processor) 100) receives seismic noise and obtain a noise interferometry, computing synthetic dispersive surface wave signals, generating a differential adjoint tomography based on observed dispersive surface wave from the noise interferometry. The processor) 100) estimates a shear wave velocity from the differential adjoint tomography, using the estimated tomography to estimate the characteristic of the region, and the processor) 100) provide a diagram with characteristic of the region through a display or printer.

IPC Classes  ?

• G01V 1/28 - Processing seismic data, e.g. for interpretation or for event detection
• G01V 1/30 - Analysis

Abstract

Provided is a reliable and convenient approach to achieve precise control of gene expression in the liver in vivo. The methods generally combine a doxycycline-inducible gene expression system with a Sleeping Beauty transposon vector and hydrodynamic injection, enabling efficient integration of a controllable gene expression system into the genome of hepatocytes. The doxycycline-inducible system generally allows for precise and reversible control of gene expression. In some forms, a combination of gene alterations and overexpression of Myc leads to the development of HCC in animals. The method can also use a vector that allows for the inducible expression of a tumor antigen. The method can also induce tumor antigen-specific T-cell immune responses, providing a potent tool for the development of targeted therapies for HCC.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• A61P 35/00 - Antineoplastic agents

Abstract

A system and devices provide for accurate localization of orthopedic implants based on magnetic tracking approach (MTA) technology and without radiation. The system includes at least one magnetic beacon that is joined to an orthopedic screw/implant fixed to a patient's spine. A detector in the form of a magnetic sensor array detects the magnetic field from the beacon and produces an electrical signal in response thereto. A computer using a multi-objective magnetic location algorithm tracks the spatial position and movement of the beacon based on the electrical signal, and hence tracks the patient's spine.

IPC Classes  ?

• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies

Abstract

A hypoventilation physical model is provided. Particularly the physical model includes brainstem and cerebral organoids derived from pluripotent stem cells (PSCs) having a PHOX2B gene mutation. This mutation includes polyalanine repeat expansion mutations (PARMs), specifically 5-PARM, 7-PARM, and 13-PARM. These PARMs occur within a 20-alanine (20-Ala) polyalanine tract in exon 3 of the PHOX2B gene. The physical model provides a platform for studying impaired ventilatory responses and associated neuronal defects, offering a valuable tool for drug screening and the development of therapeutic strategies for hypoventilation syndromes.

IPC Classes  ?

• C12N 5/079 - Neural cells
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12N 9/22 - Ribonucleases

Abstract

An ultrafast wide-field quantum sensing device using a neuromorphic event-based vision sensor includes a laser generating a laser beam; a dichroic mirror directing the laser beam onto a diamond sample and passing the laser beam reflected from the diamond, and an event camera receiving from the dichroic mirror the beam reflected from the diamond. A source of microwave energy applied to the diamond. A pulse generator synchronizes the microwave source and the event camera to create CW-ODMR measurements, wherein trigger pulses from the pulse generator are applied to the camera and microwave source. The optically detected magnetic resonance (ODMR) resonance frequency is determined based on the CW-ODMR measurements.

IPC Classes  ?

• G01R 33/32 - Excitation or detection systems, e.g. using radiofrequency signals
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping

Abstract

It has been discovered that the presence of cholinergic T cells is important for an effective immune response to hepatocellular carcinoma (HCC). The results demonstrate a novel aspect of the regulation of cancer immunosurveillance by an immune cell-derived neurotransmitter and shed light on its role in supporting cells mounting anti-tumor responses. Disclosed are methods of treating HCC in a subject in need thereof. Generally, the methods involve treating the subject with a therapy effective to increase the level of acetylcholine in T cells. Also disclosed are method where the subject is treated with anti-PD-1 immunotherapy when the determined level of cholinergic T cells in the subject is high or refraining from treating the subject with anti-PD-1 immunotherapy when the determined level of cholinergic T cells in the subject is low.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 35/00 - Antineoplastic agents

Abstract

The subject invention pertains to photocleavable prodrugs that facilitate the controllable drug delivery to the target sites modulated by light irradiation, including a photocleavable boron-dipyrromethene-derived prodrug and a dye, which achieved both high prodrug loading capacity (˜99%) and efficient light-triggered prodrug activation. The incorporation of the dye not only stabilized the nanoparticles and contributed tumor targeting as usual. but also exhibited degradation after light irradiation and in-situ monitoring of nanoparticle dissociation by fluorescent imaging.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo

Abstract

A quantum-inspired parallel annealing method that enables full parallelism and improves solution quality, resulting in significant speed and energy improvement when implemented in analog memristor crossbars. Tasks are experimentally solved, including unweighted and weighted Max-Cut and traveling salesman problem using an integrated memristor chip. The method claimed herewith effective exploits the natural parallelism, analog conductance states and all-to-all connection provided by memristor technology, and therefore demonstrates significant improvements in time- and energy-efficiency compared to previous simulated annealing and Ising machine implemented on other technologies, having a large potential for solving complex optimization problems with greater efficiency.

IPC Classes  ?

• G06F 17/18 - Complex mathematical operations for evaluating statistical data
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or

Abstract

A mechanoionic current generator comprising: a working electrode including an activated carbon cloth; and a counter electrode including a raw carbon cloth and a hydrogel; wherein the hydrogel has a plurality of flexible and asymmetrically shaped structures; and the working electrode has a surface immersed in the hydrogel and provided with a plurality of oxygen-containing functional groups. The ionic current generation mechanism of the current generator is naturally compatible with living organisms and living hydrogels, as exemplified by a self-powered drug delivery patch for wound healing. The current generator provides excellent outputs of current and charge transfer which are advantageous for various biomedical applications.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• H02N 1/04 - Friction generators
• H02N 2/00 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction
• H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators

Abstract

A SDT computation system is provided. The SDT computation system includes a SDT module, an ACAM array, and a mapping module. The SDT module is for outputting a final probability and configured to provide a SDT structure with a root node and deeper inner nodes for calculating probability, in which the final probability of each leaf node of the SDT structure is a product of all of node probabilities along a path from the root node to each leaf node, and wherein a final output of the SDT module is from a leaf with the highest probability. The mapping module is configured to map the SDT structure into the ACAM array, such that each of the ACAM cells in the ACAM array has a threshold programmed to be a parameter for a node in a path leading towards the leaf node of the SDT structure.

IPC Classes  ?

• G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements
• G06N 7/02 - Computing arrangements based on specific mathematical models using fuzzy logic
• G11C 27/00 - Electric analogue stores, e.g. for storing instantaneous values

Abstract

The I-DID system is strengths-weaknesses based assessment and intervention for dyslexia, particularly for dyslexia in bilingual users. The system includes a database comprising a large-scale profile of a plurality of user performance sets across five domains: language and literacy, cognition, creativity, music, and social-emotional skills. A machine learning-based subgroup generator creates subgroups to provide individualized intervention for each of the subgroups, such that the users in the different subgroups receive different interventions. The interventions comprise training in one or more domain-general cognitive and music skills, or language-specific listening, speaking, reading, writing, or combinations thereof. The combined theory-and data-driven approach of the system integrates multiple layers of online multifaceted assessments and classifies strength-weakness profiles of bilingual users for self-managed, personalized game-based intervention. The system promotes affordability, efficiency, equality and sustainability of clinical diagnosis and treatment for bilingual users along with users growing up in a multilingual environment.

IPC Classes  ?

• G09B 19/06 - Foreign languages
• G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
• G10L 15/22 - Procedures used during a speech recognition process, e.g. man-machine dialog

Abstract

GREM2 compositions and formulations thereof are described for use in treating or preventing one or more symptoms of a disease associated with loss of bone mineral density. Recombinant GREM2 have been shown to reduce bone resorption, reduce bone turnover markers, and increase bone strength. Methods of using the GREM2 compositions and formulations are also provided. Preferably, the pharmaceutical formulation containing GREM2 is administered via parenteral route to prevent or alleviate one or more symptoms of osteoporosis, osteopenia, bone fractures, and/or bone cancer.

IPC Classes  ?

• C07K 14/51 - Bone morphogenic factorOsteogeninOsteogenic factorBone-inducing factor
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 19/00 - Drugs for skeletal disorders
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• C12N 15/12 - Genes encoding animal proteins

Abstract

The present invention provides a solution-processed metallic nanoparticle reflective electrode, which forms well-dispersed compactly packed structures during the stacking process. Featuring the self-packing ability of metallic nanoparticles and a higher space proportion, ligand-assisted metallic nanoparticles with a uniformdistribution of particle size and superior storage stability can formhigh-quality metallic nanoparticle filmin low-temperature sintering. Finally, attributing to the superior electrical and optical properties, and facile post-treatment of electrodes, a fully solution-processed OSCs with the ligand-assisted metallic nanoparticles electrodes achieve the record high efficiency of 14.69% for large-area devices (≥ 1 cm2).

IPC Classes  ?

• H10K 30/81 - Electrodes

Abstract

Described herein are methods for preparing chiral α-amino acids using chiral phosphoric acids as catalysts. The disclosed methods can use amino-malonic acids as substrates to generate chiral amino acids with a variety of side chains in high optional purity (such as an ee value of at least 70%) and with a high yield (i.e., a yield of at least 80%, such as in a range from about 80% to about 99%), via an asymmetric decarboxylation reaction. The decarboxylation reaction of the methods is catalyzed by chiral phosphoric acids that can achieve a selective protonation during decarboxylation, which is considered one of the most difficult processes in asymmetric catalysis.

IPC Classes  ?

• C07C 227/18 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• C07C 229/42 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• C07C 235/52 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
• C07C 247/12 - Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
• C07C 255/30 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
• C07C 255/58 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 317/48 - SulfonesSulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
• C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 209/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
• C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 317/30 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 411/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 493/04 - Ortho-condensed systems
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Abstract

The present invention provides a method for scalable fabrication of ultra-flat polycrystalline diamond membranes, the method comprising: (1) performing chemical vapor deposition on a growth substrate having diamond seeds thereon to grow a polycrystalline diamond membrane, wherein an exposed surface of the polycrystalline diamond membrane is a grown surface having a first roughness; and a surface bonded to the growth substrate is a buried surface; (2) bonding the grown surface to a transfer substrate using an adhesive; and (3) removing the growth substrate to expose the buried surface of the polycrystalline diamond membrane, wherein the buried surface has a second roughness after exposure, and the second roughness is less than the first roughness.

IPC Classes  ?

• C30B 28/14 - Production of homogeneous polycrystalline material with defined structure directly from the gas state by chemical reaction of reactive gases
• C30B 29/04 - Diamond
• C30B 29/64 - Flat crystals, e.g. plates, strips or discs
• C30B 33/12 - Etching in gas atmosphere or plasma
• C30B 35/00 - Apparatus not otherwise provided for, specially adapted for the growth, production or after-treatment of single crystals or of a homogeneous polycrystalline material with defined structure

Abstract

Provided herein is a platform that supports the survival and phenotype maintenance of leukemia cells by co-culturing the cells with 3DON. The 3D osteogenic niche (3DON) mimics that in bone marrow to support AML cell survival in cultures before treatment with sample chemotherapy drug. The 3DON is comprised of osteogenically differentiated mesenchymal stromal cells (MSCs) microencapsulated in 3D microspheres made from extracellular matrix (ECM). Also provided is a method that increases the chemo-sensitivity of leukemia cells by co-culturing them with 3DON. The platform may be used for drug screening applications and the 3DON may be used as an adjuvant for chemotherapy.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A transcorneal electrical stimulation (TES) apparatus for treating brain diseases is provided. The apparatus includes an eye-contacting interface with at least one active electrode, an inactive reference electrode, and a current source. Both the active and reference electrodes are electrically connected to the current source, facilitating transcorneal electrical stimulation for various applications.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

Provided is a singlet oxygen-cleavable anti-VEGF prodrug. Provided is a composition comprising a photosensitizer and biocompatible polymer for the co-assembly of photoactivatable nanoparticles with the singlet oxygen-cleavable anti-VEGF prodrug. This red-light-activatable prodrug composition can be used in methods for the combined anti-angiogenesis and PDT treatment of wet AMD and other diseases, capable of light-controllable drug delivery to the CNV lesions and other disease sites via noninvasive intravenous administration.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/51 - Nanocapsules
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61P 27/02 - Ophthalmic agents

Abstract

Ocular antimicrobial compositions and methods and method of use thereof are provided. The compositions incorporate photoactive heterojunction materials can be incorporated into a suitable carrier, alone or in combination with an enzyme capable of generating ROS upon contact with the eye for the treatment of ocular conditions. The method includes contacting the eye of a subject in need thereof, the subject has or has been diagnosed with microbial keratitis, with an effective amount of the disclosed composition. The method further includes contacting the composition in the subject's eye with near infrared radiation (NIR).

IPC Classes  ?

• A61K 38/44 - Oxidoreductases (1)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/06 - Tripeptides
• A61K 38/07 - Tetrapeptides
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• A61P 27/02 - Ophthalmic agents
• A61P 31/04 - Antibacterial agents

Abstract

A positioner comprising a nested pair of robots suitable for MRI-guided live-imaging, head-mounted bilateral stereotactic neurosurgery. Specifically, the positioner is suitable for locating a needle holder for tubular/needle-like instrument during neurosurgical operation. While maintaining a sufficient workspace (± 35°), the positioner remains lightweight (203 g) and compact ( Ø 81 mm × 97 mm height), enabling skull-mounted usage within most standard imaging head coils. The five-bar linkage architecture allows the reservation of exposure space around the incision port (burr hole on the skull) for operation/observation. The robot system operates in two stages: i) manual coarse adjustment within a large workspace performed interactively by the surgeon, followed by ii) automated fine adjustment within a localized motion range performed by soft fluid-driven actuators.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 17/06 - NeedlesHolders or packages for needles or suture materials

Abstract

Provided herein are insulin receptor (INSR) agonists compounds of Formula I-IV or compositions containing the compounds, the use of these compounds or compositions in the treatment of diabetes. The compounds and compositions can bind to the allosteric sites on INSR and activate INSR and downstream signaling pathways synergistically with insulin by phosphorylating INSR proteins.

IPC Classes  ?

• C07K 5/065 - Dipeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

An event-guided auto-exposure (EG-AE) device leverages the high dynamic range and low latency properties of a dynamic vision sensor to guide the exposure setting of an active pixel sensor. The method utilizes physical connections of images and events to estimate the irradiance variations, which are fed into the EG-AE device for calculating the exposure setting. The method shows outstanding performance in tackling highly challenging lighting conditions and benefits multiple downstream applications, including visual tag detection and feature matching.

IPC Classes  ?

• H04N 23/73 - Circuitry for compensating brightness variation in the scene by influencing the exposure time
• H04N 23/71 - Circuitry for evaluating the brightness variation
• H04N 23/72 - Combination of two or more compensation controls
• H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
• H04N 25/47 - Image sensors with pixel address outputEvent-driven image sensorsSelection of pixels to be read out based on image data

Abstract

The present invention relates to an ultrasensitive rapid antigen detection kit for detecting N protein from SARS-CoV-2 virus in a sample, and methods for detecting N protein. The kit includes a sample collector, a collection and enrichment tube and a rapid antigen detection component with a test strip. The collection and enrichment tube contains a first part containing lyophilized ATPS reagents and a second part containing a lysis buffer. The sample is mixed with the lyophilized ATPS reagents and the lysis buffer to form a mixture. The enrichment is realized by concentrating the target analyte into one of the two phases formed by ATPS.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Compositions and methods for the reliable molecular monitoring of NPM1 mutations are disclosed. The methods enable pre-emptive therapy essential for understanding AML disease status, informing therapeutic options, monitoring therapeutic efficacy, and improving patient outcome. The methods simultaneously screen and quantify samples having the major NPM1 mutant subtypes. In some forms, methods for detecting and measuring a presence, absence, and/or level of mutation of the NPM1 gene in a sample include hybridizing labelled sequence probes to the NPM1 gene in a sample to form labelled probe-nucleic acid conjugates, amplifying the probe-nucleic acid conjugates, and detecting the labelled probe-nucleic acid conjugates by measuring the level of one or more labels attached to the probes. The methods optionally record the presence, absence and/or level of NPM1 mutations in the sample.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

A method for aquatic microplastic identification is provided. The method includes steps as follows: emitting a laser beam from a laser source, such that the laser beam passes through a liquid sample with MP samples in a sample channel and then a polarizer and is received by polarization camera; capturing a sample image of the MP samples by the polarization camera, wherein the sample image comprises interference patterns resulting from superposition of object and reference waves; and feeding the interference patterns into a morphology analyzing module for real-time tracking and analyzing by using a lightweight convolutional neural network (CNN) model, so as to classify the MP samples.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G03H 1/00 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto
• G03H 1/04 - Processes or apparatus for producing holograms
• G06V 10/147 - Details of sensors, e.g. sensor lenses
• G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• H04N 23/55 - Optical parts specially adapted for electronic image sensorsMounting thereof

Abstract

The present invention provides a statistical acoustic sensing (SAS)-based method and system for in-vehicle Child Presence Detection. The SAS-based method comprises: transmitting acoustic signal to a subject in a vehicle cabin; receiving acoustic multipath signals scattered by the subject; and processing the acoustic multipath signals to detect presence of the subject by: extracting a plurality of channel impulse response (CIR) data from the received acoustic multipath signals; aggregating the extracted CIR data to estimate acoustic channel state information (CSI); obtaining an autocorrelation function (ACF) of the acoustic CSI based on a statistical acoustic sensing (SAS) model; and performing motion detection and breath tracking on basis of the ACF to detect presence of the subject in the vehicle cabin. The present invention can leverage in-car audio systems to detect presence of young children including newborns in an accurate and responsive manner.

IPC Classes  ?

• G01S 15/04 - Systems determining presence of a target
• A61B 8/08 - Clinical applications
• B60Q 9/00 - Arrangement or adaptation of signal devices not provided for in one of main groups
• G01S 15/50 - Systems of measurement based on relative movement of target

Abstract

Methods for detecting adaptive immune responses to pathogens or self-antigens by antibody or B cell or T cell binding to antigenic epitopes have been established. The methods inform functional and structural interactions between immune receptors and antigens, identify potential therapeutic targets and guide vaccine development. The methods employ high throughput modified mRNA-display or variations of droplet display to determine single epitope-specific antibody and B- and T- cell receptor sequences at the genomic scale at single epitope and single amino acid resolution. In some forms, the methods collect and integrate the data to provide a database of an adaptive immunity profile for a human or animal subject. In some forms, the methods identify and record changes in an immunity profile over different time points to reflect immunological responses in a subject. The methods provide high resolution immunity profiles of immune responses at the genomic level for diagnostic, prophylactic, and therapeutic applications.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• C07K 14/74 - Major histocompatibility complex [MHC]

Abstract

A smart skin system includes tactile sensors that mimic the functions of human skin by sensing pressure, vibration and humidity simultaneously and generate electric signals as a result thereof; and a machine learning assisted data processor that interprets the electric signals from the sensors and quantitively perceives the stimulation in terms of pressure, vibration, and environmental humidity. The sensor structurally comprises (1) a single-ion conducting electrolyte, which provides contact electrification, serves as a hygroscopic layer and produces DC hygroelectric signals in response to humidity, (2) a gold electrode and (3) a separatable aluminum electrode as a counter triboelectrification layer that produces AC triboelectric signals in response to contact.

IPC Classes  ?

• G01L 1/00 - Measuring force or stress, in general
• G01H 1/00 - Measuring vibrations in solids by using direct conduction to the detector
• G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance

Abstract

A switchable triboelectric nanogenerator (s-TENG) which obtains energy by utilizing the electrostatic potential between water droplets and frictional surfaces. The s-TENG device includes an ITO film substrate as an electrode, a SU-8 mold grid located on the ITO film substrate and forming an array of air gaps as an air breakdown region, and a FEP film on the SU-8 mold grid as the surface of the friction layer. A water source is variably positioned at a distance from and at an angle to the s-TENG device so that water droplets contact the friction layer, so that direct current is obtained without the use of a rectifier due to electrostatic induction causing break down in the air breakdown region of the SU-8 mold grid.

IPC Classes  ?

• H02N 1/04 - Friction generators

Abstract

The subject invention pertains to novel compounds, compositions containing the novel compounds, and methods for targeting gram-positive bacteria with the compounds or compositions of the subject invention. The subject invention further pertains to novel compounds, novel compositions, and methods for targeting gram-positive bacteria persister cells and gram-positive bacterial biofilms. The subject compounds and compositions can target gram-positive bacteria by modulating the proton motive force, calcium influx, autolysis, or any combination thereof. The novel compounds are synthetic, small molecules that can induce the death of gram-positive bacteria.

IPC Classes  ?

• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/36 - Compounds containing methylenedioxyphenyl groups, e.g. sesamin
• A61K 31/404 - Indoles, e.g. pindolol
• A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/505 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61P 31/04 - Antibacterial agents
• C07C 259/10 - Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
• C07D 209/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 239/42 - One nitrogen atom
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07D 295/135 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• C07D 295/16 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
• C07D 317/66 - Nitrogen atoms not forming part of a nitro radical

Abstract

Broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier are provided. The antiviral compositions show a strong broad spectrum antiviral effect, without resulting to viral resistance. The disclosed antiviral compositions are useful for treatment of diseases caused by viral infections, particularly respiratory viruses such as enveloped coronaviruses (SARS-CoV-2, SARS-CoV and MERS-CoV), the pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, and the non-enveloped rhinovirus.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

A 3-dimensional (3D) bioprinted cell culture system of tumor tissue, methods of making and methods of use thereof are described. The 3D cell culture system provides multiple compartments and vasculature as well as cellular interfaces including tumor/non-tumor interface, tumor-vasculature interface to recreate tumor immune microenvironment. 3D bioprinted scaffold enables adjustment of stiffness to reflect the different stages of carcinogenesis including fibrosis, cirrhosis, and steatosis; and establishing chemical gradients, for example, oxygen levels, to mimic oxidative stress and hypoxia condition. Fabrication of the 3D cell culture is achieved by bioprinting such as micro-molding, inject exclusion and suspension bioprinting techniques.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12N 5/09 - Tumour cells
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

A method of testing a participant's ability to accurately detect speech in the presence of background noise includes: (a) audibly presenting a series of 2 digits, 3 digits, 4 digits and/or 5 digits, in random or fixed orders, to a first ear of a participant in quiet or in noise at a fixed or varied signal-to-noise ratios (SNRs), (b) audibly presenting a series of 2 digits, 3 digits, 4 digits and/or 5 digits, in random or fixed orders, to a second ear of a participant in quiet or in noise at a fixed or varied signal-to-noise ratios (SNRs), wherein the digits are presented in a language native to the participant or in which the participant is fluent, (c) recording digits or digit sequences identified correctly by the participant and (d) calculating scores based on the percentage of digits or digit sequences repeated correctly by the participant or the difference in level between speech and noise to yield 50% of the digit sequences being identified correctly.

IPC Classes  ?

• A61B 5/12 - Audiometering

Abstract

The present disclosure relates to a world first and only authentic EBV-positive cisplatin-resistant NPC PDX, xeno76-CR, which has been tested with different examinations and is confirmed as cisplatin-resistant EBV-positive undifferentiated human NPC. Xeno76-CR is a valuable preclinical model that mimics the NPC patients who have failed chemotherapy. It could predict the treatment outcome in drug testings, increase the success rate for new therapeutic agents when proceed into clinical trial, and ultimately benefit NPC patients with more choices of promising therapy.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/09 - Tumour cells
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

ROS-responsive prodrugs and methods of making thereof are disclosed. These prodrugs can contain two captopril moieties and one cinnamaldehyde moiety that are linked by a thioacetal linking moiety; upon cleavage of the thioacetal linking moiety by ROS, the prodrugs can release two captopril or captopril derivatives and one cinnamaldehyde or cinnamaldehyde derivative. Pharmaceutical formulations in a unit dosage form suitable for the delivery of the prodrugs to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more additional anti-inflammatory active agents in their free form. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating an inflammatory disease or disorder, or treating or ameliorating one or more symptoms associated with an inflammatory disease or disorder in a subject are also disclosed. The inflammatory disease or disorder can be rheumatoid arthritis.

IPC Classes  ?

• C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

A high-throughput single-file focusing system and methods for polydisperse particles are provided. The system includes a microfluidic device for pre-focusing the polydisperse particles and a high-aspect-ratio (HAR) rectangular structure coupled to the microfluidic device. The microfluidic device includes a fluidic channel configured to localize distributions of the polydisperse particles in a cross-sectional area of the fluidic channel. The dimensions of the fluidic channel are configured to generate a converging secondary flow having four spiral vortices that drives the polydisperse particles to flow inward following a spiral path to be concentrated into a center of each spiral vortex such that the polydisperse particles are focused by the converging secondary flow without any inertial force. The coupled HAR rectangular structure receives the pre-focused polydisperse particles and further confines the particles to form a single file on its mid-plane.

IPC Classes  ?

• G01N 15/1409 - Handling samples, e.g. injecting samples
• G01N 15/10 - Investigating individual particles
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1404 - Handling flow, e.g. hydrodynamic focusing
• G01N 15/149 - Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

Abstract

A method for hybrid-domain reconstruction of MRI images includes the steps of (A) extracting null-subspace bases of a calibration matrix from k-space coil calibration data to calculate image-domain spatial null maps (SNMs) and (B) reconstructing multi-channel images by solving an image-domain nulling system formed by SNMs that contain both coil sensitivity and finite image support information, thus circumventing the masking-related procedure and demonstrating a robust reconstruction.

IPC Classes  ?

• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/48 - NMR imaging systems
• G01R 33/561 - Image enhancement or correction, e.g. subtraction or averaging techniques by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences
• G01R 33/58 - Calibration of imaging systems, e.g. using test probes
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

A thin film composite nanofiltration (TFC-NF) membrane is produced by forming a dispersion of aramid nanofibers (ANFs) in a water miscible polar organic solvent that is formed into a thin film that is contacted with an aqueous solution of a di- and/or poly-amine. This amine absorbed film has a solution of one or more di-, tri, and/or poly acid chlorides in a water immiscible polar organic solvent poured onto the supported film. Upon removal of residual solutions, optionally the film can be activated, and upon drying the TFC-NF membrane is isolated. The TFC-NF membrane produced by this process is superior in permeability and selectivity for use in water purification by nanofiltration.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 71/56 - Polyamides, e.g. polyester-amides
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C08J 7/04 - Coating

Abstract

A soldering lug, a soldering assembly and a preparation method therefor. The soldering lug comprises: a copper substrate, having a first surface and a second surface opposite to each other; and at least one nanometal layer, deposited on at least one of the first surface and the second surface of the copper substrate, wherein the yield strength of the soldering lug is not greater than 100 MPa. The soldering assembly comprises: a first base plate; a second base plate; and a soldering portion located between the first base plate and the second base plate for connecting the two; the soldering portion comprises a copper substrate, a first soldering interface on a first side of the copper substrate, and a second soldering interface on a second side of the copper substrate opposite to the first side; the first soldering interface and the second soldering interface are formed by bonding nanometal on the opposite sides of the copper substrate to the first base plate and the second base plate, respectively; and the shear strength of the soldering assembly is not less than 40 MPa.

IPC Classes  ?

• B23K 35/30 - Selection of soldering or welding materials proper with the principal constituent melting at less than 1550°C
• B23K 35/02 - Rods, electrodes, materials, or media, for use in soldering, welding, or cutting characterised by mechanical features, e.g. shape

Abstract

A human balance sensor for assessing the risk of the user falling includes a transparent glass plate, a latex sheet located on the top surface of the glass plate, a light source located so as to inject light into edge of the glass plate and a high resolution camera located below the glass plate so as to capture light diffused from the glass plate when pressure is applied thereto by the user's foot. Based on the principle of Frustrated Total Internal Reflection (FTIR), when user stands with his feet on the glass plate a condition of total internal reflection is eliminated at pressure locations due to the pressure from the feet, and diffused light passes from the bottom surface of the glass plate and forms a haptic image of the contact area of the feet which can be analyzed over time to determine the user's ability to balance, and hence their risk of a fall.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

A chromic liquid capable of responding to and reproducing external optical color illumination is formed as a TiO2 colloid imbued with three sensitizing dyes. The dyes are (a) SQ2 (5-carboxy-2-[[3-[(2,3-dihydro-1,1-dimethyl-3-ethyl-1H-benzo[e]indol-2-ylidene)methyl]-2-hydroxy-4-oxo-2-cyclobuten-1-ylidene]methyl]-3,3-dimethyl-1-octyl-3H-indolium), (b) LEG4 (3-{6-{4-[bis(2′,4′-dibutyloxybiphenyl-4-yl)amino-]phenyl}-4,4-dihexyl-cyclopenta-[2,1-b:3,4-b′]dithiophene-2-yl}-2-cyanoacrylic acid) and (c) L0 (4-(diphenylamino) phenylcyanoacrylic acid). The liquid reproduces cyan, magenta and yellow color or a mixture thereof in response to exposure to illumination by light of various colors.

IPC Classes  ?

• C09K 9/02 - Organic tenebrescent materials
• C01G 23/047 - Titanium dioxide

Abstract

A method is provided for remotely assuring the quality and transportation of offsite construction components. The method involves placing a code on the module, where the code contains identity information about the module. Then the code is scanned to obtain the identity information and to upload it to a blockchain data storage facility. Access is allowed to the identity information in the blockchain data storage facility to relevant parties for the purpose of remotely inspecting the module to verify its quality. Based on this verification the module may be delivered to a transportation facility for transport. During transport location information about the module is collected and uploading it to blockchain data storage facility. Second access is allowed to the location information stored in the blockchain data storage facility to allow relevant parties to remotely understand the transportation situation of the module.

IPC Classes  ?

• G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light

Abstract

It has been discovered that overexpression of DLC1-i1 partly rescues neuronal formation and apoptosis of neuromuscular cells in subjects with spinal muscular atrophy (SMA). Since loss of DLC1-i1 confers specific MN defects in SMA, compositions and methods thereof for the treatment of SMA by delivery of AAV-SYN-DLC1-i1 into the neuronal population of subject with SMA are provided. The methods improve survival and restore locomotion ability to a greater extent than that of commercially-available compositions and methods. Methods including administration of both DLC1-i1 and SMN1 transgenes provide synergistic effects in improving the survival and enhancing locomotion ability in subject with SMA.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided is a system for drug delivery comprising a modified poly (amidoamine) (“PAMAM”) comprising a photo-cleavable compound bound to one or more active agents to form a nanocomplex. Also provided is a method of treating a subject comprising administering the PAMAM nanocomplex and irradiating the nanocomplex at the target site with a light source. In particular, the modified PAMAM is a DEACM-modified PAMAM or a BODIPY-modified PAMAM. Also provided is a method for screening for PAMAM-coumarin-active agent nanocomplexes.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Abstract

It has been discovered that γδ-T-extracellular vesicles (EV) have immune adjuvant effects that promote DCs maturation, mediated by the IFN-γ associated with the γδ-T-EVs. Cell-free compositions including extracellular vesicles (EVs) derived from γδ-T cells (γδ-T-EVs) and methods of use thereof are provided. The γδ-T-EVs can associated with or encapsulate tumor-associated antigens (TAAs) or peptide pools to form a γδ-T-EV vaccine composition. γδ-T-EVs compositions can be used as adjuvants in cancer immunotherapy or the γδ-T-EV vaccine compositions are to induce tumor-specific T-cell responses and direct killing of tumor cells in subjects in need thereof.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents
• A61K 47/46 - Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Abstract

An Al—Si coated press hardening component, wherein the Al—Si coating comprises a low-Al content ferrite layer with an Al content of less than 5 wt % and a thickness of greater than 5 μm, and having a maximum bending angle of the Al—Si coated press hardening component is greater than 65°. The thickness of the tough low-Al content ferrite layer in the Al—Si coating after hot stamping, reaching 5-100 μm, by improving the hot stamping process, so that the formation or propagation of cracks on the surface or the coating is effectively prevented, and the bendability of the pre-coated steel after hot stamping is improved. At the same time, the hot stamping process of the present invention can take into account or optimize the microstructure of the steel substrate to further improve the bendability and tensile property of the whole material.

IPC Classes  ?

• C21D 8/00 - Modifying the physical properties by deformation combined with, or followed by, heat treatment
• C21D 1/84 - Controlled slow cooling

Abstract

Provided is a composition that comprises a hydrogel and an ionic thermoresponsive shape-changing liquid crystal elastomer (ILCE). Provided is a medical device comprising the composition. Provided is a system comprising the composition and a heating source. Provided is a method ofself-healing ofa hydrogel composition.

IPC Classes  ?

• A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

An electroconductive hydrogel is formed by hybrid assembly of polymeric nanofiber networks of conducting polymers that self-organize into highly connected 3D nanostructures with an ultralow threshold (˜1 wt %) for electrical percolation. A method for forming the electroconductive hydrogel comprises the steps of: dispersing aramid nanofibers (ANFs) in dimethyl sulfoxide (DMSO); conducting a solvent exchange with water to generate hydrogels with connective 3D fibrillar networks that serve as templates for the assembly of conducting polymers; incorporating polyvinyl alcohol (PVA) during the processing of the hydrogels to weld the fibrillar joints via hydrogen bonding; infiltrating monomers into the nano-porous hydrogels in an aqueous media; and polymerizing the hydrogels with added oxidants.

IPC Classes  ?

• C08L 29/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• A61B 5/251 - Means for maintaining electrode contact with the body
• A61B 5/268 - Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
• A61B 5/28 - Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
• A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]
• A61L 31/04 - Macromolecular materials
• A61L 31/14 - Materials characterised by their function or physical properties
• C08J 3/075 - Macromolecular gels
• F24S 70/14 - Details of absorbing elements characterised by the absorbing material made of plastics

Abstract

Compositions and method of reducing Tau phosphorylation in neurons of a subject in need thereof are provided. In some embodiments, the subject has a proteinopathy, amyloidosis, or a tauopathy. Thus, compositions and methods of treating a proteinopathy, amyloidosis, or a tauopathy are also provided. Also disclosed are compositions and methods of increasing learning and/or memory in a subject with a tauopathy. The methods typically include administering the subject an effective amount of a direct or indirect inhibitor of Pax6 (Pax6 inhibitor). The Pax6 inhibitor can be, for example, a small molecule or a functional nucleic acid. In some embodiments, the small molecule is palbociclib, apigenin, flavopiridol, abemaciclib, ribociclib, or ICCB280, or a derivative, stereoisomer, or pharmaceutically acceptable salt thereof. In some embodiments, the functional nucleic acid including but not limited to siRNA, shRNA, or miRNA, or a nucleic acid expression construct encoding an siRNA, shRNA, or miRNA.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed are biomarkers and methods for accurate non-invasive diagnosis or prognosis of liver fibrosis in subjects with non-alcoholic fatty liver disease (NAFLD). The biomarkers include circulating levels of thrombospondin 2 (TSP2) and can be measured at any time during the course of the disease. The methods include any one of non-invasive evaluation of circulating levels of TSP2 alone, or together with other molecular biomarkers, physiologic or radiographic biomarkers. The methods are highly sensitive and detect advanced liver fibrosis with a sensitivity of about or greater than 80%. The methods may use the circulating levels of TSP2 alone, or together with other molecular biomarkers, physiologic or radiographic biomarkers to accurately predict the risk of developing advanced liver fibrosis in a subject.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A computer-implemented geometric processing method generates the design for a model of a dental prosthesis beginning with obtaining a blended prosthesis dataset for dental prostheses including natural tooth data and prosthesis tooth data designed by a technician. This dataset is preprocessed by generating a depth map with preprocessing so that the data is more suitable for deep learning (DL) so as to ensure generation of a smooth surface. An artificial intelligence neural network generation model with tooth feature loss is trained on the preprocessed dataset and is used to form a model of the prosthesis. Then the dental information associated with the dental model of dentition is used to generate a 3D dental prosthesis surface with a post-processing method to meet the requirement of the dental prosthesis. Finally, the rest of the dental prosthesis is completed to meet full function.

IPC Classes  ?

• G06F 30/10 - Geometric CAD
• A61C 13/34 - Making or working of models, e.g. preliminary castings, trial denturesDowel pins
• G06T 5/20 - Image enhancement or restoration using local operators
• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• G06T 5/70 - DenoisingSmoothing
• G06T 5/73 - DeblurringSharpening

Abstract

This invention provides a method to increase antigenicity or immunogenicity of a tumor in a subject. The said method comprises the step of delivering lipid nanoparticles loaded with mRNA encoding one or more pathogen antigen proteins into said tumor.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/02 - Bacterial antigens
• A61K 39/12 - Viral antigens
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• C12N 15/40 - Proteins from RNA viruses, e.g. flaviviruses
• C12N 15/44 - Orthomyxoviridae, e.g. influenza virus
• C12N 15/45 - Paramyxoviridae, e.g. measles virus, mumps virus, Newcastle disease virus, canine distemper virus, rinderpest virus, respiratory syncytial viruses
• C12N 15/50 - Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
• C12N 15/49 - Lentiviridae, e.g. immunodeficiency viruses such as HIV, visna-maedi virus, equine infectious anaemia virus
• C12N 15/51 - Hepatitis viruses
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis

Abstract

A method of improving an information transmission rate involves reducing atmospheric distortions by emitting at the same or nearly the same wavelength a reference source for adaptive optic correction and a signal source for optical communication. The reference source is brighter than the signal source and the (pulsed or continuous) reference source is emitted earlier than the (pulsed or continuous) signal source. By adjustment of the time delay between the reference source and the signal source and/or the delay time in adaptive optics control and/or apparent angular speed of the sources relative to the detecting module and/or the physical separation between the reference source and the signal source, the optical paths of a reference source beam and a signal source beam have about same wavefront distortion. The reference source beam and the signal source beam are detected in a side by side manner by detectors physically located next to each other. Adaptive optics are used for wave distortion correction on the reference source to simultaneously correct distortion of the signal source.

IPC Classes  ?

• H04B 10/50 - Transmitters
• H04B 10/572 - Wavelength control

Abstract

Compositions and methods involving microspheres composed of mesenchymal cells such as dermal papilla cells (DPCs) and extracellular matrix, epithelial cell such as keratinocyte are disclosed. It has been discovered that by balancing the proportion of DPCs and extracellular matrix in the DPC-matrix mixture, and by incubating a particular range of small volume of the DPCmatrix mixture, DPC-matrix microspheres can be formed that have useful properties. Most significantly, the resulting DPC-matrix microspheres are particularly suited to be used to produce bioengineered hair follicles that have features of native hair follicles.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• A61K 35/36 - SkinHairNailsSebaceous glandsCerumenEpidermisEpithelial cellsKeratinocytesLangerhans cellsEctodermal cells

Abstract

This invention relates to cancer immunotherapy. A method to increase antigenicity or immunogenicity of a tumor in a subject is provided. In one embodiment, said method comprises the step of delivering lipid nanoparticles loaded with mRNA sequences encoding one or more pathogen antigen proteins into said tumor.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Described herein is a novel concept of the realization of thermally activated delayed fluorescence (TADF) and thermally stimulated delayed phosphorescence (TSDP) to harvest light emission from the higher-energy singlet and triplet excited states via the up-conversion from the lowest-energy triplet excited state by efficient reverse internal conversion together with reverse intersystem crossing as well as the development of emitters with TADF and TSDP properties, as exemplified by a new class of gold (III) compounds with TADF and TSDP properties. The gold (III) compounds include N-heterocycle-containing cyclometalating tridentate ligand and one auxiliary ligand, both coordinated to a gold (III) metal centre and having the chemical structure shown in generic formula (I).

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C07F 1/00 - Compounds containing elements of Groups 1 or 11 of the Periodic Table
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/12 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising dopants

Abstract

An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.

IPC Classes  ?

• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 38/00 - Medicinal preparations containing peptides
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents
• B01J 23/50 - Silver
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C07K 14/575 - Hormones

Abstract

An oxygen scavenging article in the form of a film comprises an oxygen scavenger and a matrix in the form of a film bearing the oxygen scavenger. The oxygen scavenging article in the form of a film has excellent oxygen adsorption capability and can be further laminated with food packaging into food packaging bags. An indicator for detecting trimethylamine with excellent sensitivity comprises an oxygen scavenger. The oxygen scavenger can be used in an encapsulation layer of a perovskite solar cell. The perovskite solar cell does not undergo degradation of lead halide perovskite due to its encapsulation protective layer comprising the oxygen scavenger.

IPC Classes  ?

• B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• G01N 31/16 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using titration
• G01N 31/00 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods
• H01L 31/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof

Abstract

An all-analog spiking neural network circuit including at least one ReRAM-crossbar synapse array that conducts multiply-accumulate operations in parallel and a spike response model (SRM) neuron circuit, which is built with complementary metal-oxide-semiconductor (CMOS) technology. The neuron circuits receive outputs from the ReRAM-crossbar synapse array and directly process the output currents from the ReRAM-crossbar synapse arrays to complete the multiply-accumulate operation and produce processed voltage spike trains.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G06N 3/049 - Temporal neural networks, e.g. delay elements, oscillating neurons or pulsed inputs

Abstract

The subject invention pertains to multifunctional tendon-mimetic hydrogels constructed from anisotropic assembly of aramid nanofiber composites. The stiff nanofibers and soft polyvinyl alcohol in these anisotropic composite hydrogels (ACHs) mimic the structural interplay between aligned collagen fibers and proteoglycans in tendons. The ACHs uniquely exhibit a high modulus of ˜1.1 GPa, strength of ˜72 MPa, fracture toughness of 7333 J/m2, and many additional characteristics matching those of natural tendons. The surfaces of ACHs can be functionalized with bioactive molecules to present biophysical cues for the modulation of morphology, phenotypes, and other behaviors of attached cells. Moreover, soft bioelectronic components can be integrated on ACHs, enabling in-situ stimulation and sensing of various physiological parameters. The outstanding mechanics and functionality of these tendon-mimetics can be advantageously applied to advanced tissue engineering, implantable prosthetics, human-machine interactions, and other technologies.

IPC Classes  ?

• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers

Abstract

Provided are antibodies that specifically bind to a Talaromyces marneffei (T. marneffei) Mp1p protein. For example, such antibodies can be produced by a hybridoma cell line having the Patent Deposit Designation Number PTA-126527.

IPC Classes  ?

• C07K 16/14 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from fungi, algae or lichens
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A robot that is used to move a transducer of an MRI-guided focused ultrasound (FUS) system that can focus ultrasound at specific target spots in a patient's body to induce micro-mechanical effects. The robot has a bottom framework, a lower translation platform mounted on the bottom framework for linear motion with respect to the bottom framework. A robot base mounted on the lower translation platform, a rotation platform mounted on the robot base for rotational motion with respect to the robot base, an upper translation platform mounted on the rotation platform for linear motion with respect to the robot base and an end-effector mounted on the upper translation platform and supporting the FUS transducer such that motion of the end-effector is due to motion of the platforms while aiming the transducer focal point.

IPC Classes  ?

• A61B 34/35 - Surgical robots for telesurgery
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61N 7/02 - Localised ultrasound hyperthermia

Abstract

A method for fabricating a cladding-less GaN-based thin-film edge-emitting laser comprising the steps of: attaching a typical LED wafer to a Si substrate; removing an original sapphire substrate of the LED wafer to expose its n-GaN and the u-GaN buffer layers; thinning the film thickness to maximize the overlap factor between the resonant mode profile and the active region; depositing another reflective metallic layer on the n-GaN surface for optical confinement and electrical contact; and defining a pattern of the edge-emitting cavity by nanolithography techniques; etching to transfer the pattern to the thin film by an ICP etch.

IPC Classes  ?

• H01S 5/20 - Structure or shape of the semiconductor body to guide the optical wave
• H01S 5/343 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser
• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof

Abstract

Three-dimensional (3D) printing methods for making metal-embedded medical implants and devices are provided. The newly developed 3D printing technology and surface modification method will contribute to the wider application of 3D-printed patient-specific products in many medical fields showing excellent clinical safety.

IPC Classes  ?

• A61C 7/08 - Mouthpiece-type retainers
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]

Abstract

A system for inspecting surfaces that includes a mobile base, sensors for base navigation, sensors for surface inspection, a communication system and a host computer that executes modules for base motion planning and navigation, location, point cloud acquisition and processing, surface modelling and analysis, multi module coordination and user interfaces. The inspection procedure has the robot move in a zigzag pattern trajectory over the surface. For every fixed distance, a 3D point cloud of the surface is generated and the location of the point cloud with respect to the world coordinate system is recorded. The location of the point cloud is based on SLAM for spatial mapping. At the same time, a high-resolution photo of the corresponding area on the surface is recorded by the camera. Both the point cloud and the photo are transmitted to the host computer for processing and analysis. This information is used in a new 3D detection and image processing algorithm to find flaws in the surface like bumps or depressions. If irregular flaws are detected, the robot marks such a problematic location.

IPC Classes  ?

• G05D 1/02 - Control of position or course in two dimensions

Abstract

This invention discloses a pneumatic and cable-driven hybrid artificial muscle, comprising pneumatic actuator, pneumatic pressure regulating assembly, and cable drive assembly. The pneumatic pressure regulating assembly is connected to the pneumatic actuator to regulate air pressure in the pneumatic actuator for controlling the pneumatic actuator to extend or contract. The cable actuation assembly comprises a cable fixedly connected to the pneumatic actuator for controlling the pneumatic actuator to contract. In this invention, the artificial muscle employs a dual pneumatic and cable actuation mechanism. By leveraging the inherent stiffness of the pneumatic actuator, it can provide substantial actuation force for joint movement. Simultaneously, the cable actuation assembly can provide significant pulling force, effectively ensuring safety in human-machine interaction and offering sufficient bidirectional aiding force to individuals with disabilities who use the artificial muscle as an aiding actuation device.

IPC Classes  ?

• F15B 15/10 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
• F15B 11/064 - Servomotor systems without provision for follow-up action involving features specific to the use of a compressible medium, e.g. air, steam with devices for saving the compressible medium
• F15B 15/08 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit

Abstract

Provided are cell niche engineering platform which represents a valuable in vitro tool for investigating physiological and pathological cellular activities, an all-in-one technology to engineer cell niche (particularly soluble cell niche factors) with retained bioactivities, a mask-free, non-contact, biocompatible and multiphoton-based microfabrication and micropatterning method for engineering a spatially and quantitatively controllable soluble proteins/bioactive factors and cell-cell adhesion molecules. An universal cell niche engineering platform is provided that contributes to reconstituting heterogeneous native soluble cell niche for signal transduction modeling and drug screening studies.

IPC Classes  ?

• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

Abstract

A method of measuring cross-correlation or similarity between input features and filters of neural networks using an RRAM-crossbar architecture to carry out addition/subtraction-based neural networks for in-memory computing. The correlation calculations use L1 norm operations of AdderNet. The RCM structure of the RRAM-cross bar has storage and computing collocated, such that processing is done in the analog domain with low power, low latency and small area. In addition, the impact due to the nonidealities of RRAM device can be alleviated by the implicit ratio-based feature of the structure.

IPC Classes  ?

• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• G06F 15/80 - Architectures of general purpose stored program computers comprising an array of processing units with common control, e.g. single instruction multiple data processors
• G11C 7/10 - Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers

Abstract

A method of detecting atomic scale defects in semiconductors, comprising the steps of scanning the surface of the semiconductor with a field emission scanning electron microscope (SEM) to form an SEM image thereof; scanning the SEM image with a light detector and monochromator to obtain a cathodoluminescence (CL) spatial intensity map of the SEM image; determining the CL spectra, i.e. the CL intensity against photon energy for each integral CL intensity; and comparing the CL intensity to a threshold, whereby those semiconductors whose CL intensity is above the threshold are deemed to be defective

IPC Classes  ?

• H01L 21/66 - Testing or measuring during manufacture or treatment
• H01J 37/28 - Electron or ion microscopesElectron- or ion-diffraction tubes with scanning beams
• H01J 37/285 - Emission microscopes, e.g. field-emission microscopes

Abstract

A bioassay, which is a segregative phase separation system (SPSS) where a bioassay signal intensifier is presented. The bioassay signal intensifier is an aqueous two-phase system (ATPS) component that causes the signal to intensify in one aqueous phase of a plurality of phases formed from the bioassay composition. The source of the signal resulting from the inclusion of a test sample is selectively partitioned into one phase that can be of significantly lesser volume than in the bioassay absent the bioassay signal intensifier, such the signal's source is concentrated in that phase, and the signal is intensified.

IPC Classes  ?

• G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Abstract

The present invention relates to systems and methods for automated interpretable and generalizable biological morphological profiling. The method for identifying single-cell morphological profiling based on deep learning includes collecting and pre-processing at least one single-cell image data; training Variational Autoencoder (VAE) by defining an arbitrary dimension size of a latent space; distilling a learnt latent space from the VAE to Generative Adversarial Network (GAN) and training a generator-discriminator combination within the GAN; generating a realistic image aligned with the learnt latent space; and interpreting data by incorporating statistical variance analysis and hierarchical clustering.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/0475 - Generative networks

Abstract

An ultrahigh-throughput quantitative phase imaging (QPI) system incorporating a spinning on-the-fly cell-based assay platform with concentric rings of cell chambers (20). Each chamber (20) has an assay region (22) and a pair of inlet/outlet channels (24) with an opening (25) between their ends. The inlet/outlet channels (24) are adapted to deliver a fluid with a cell sample that has been introduced into the opening (25) to the assay region (22). The openings (25) face toward an inner radial position of the spinning platform compared to the assay region (22) so as to keep the liquid in the assay region (22) from being forced out by centrifugal force during spinning of the platform, while being open to the outer environment before, during and after spinning.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Abstract

The subject invention pertains to a comprehensive investigation of leading mechanisms of contact electrification in various liquid-liquid systems and an all-liquid TENG with optimized materials and structures to harvest energy from rainwater. Embodiments of the provided all-liquid TENG can generate a high charge density (e.g., 3.63 μC/L) with high output stability (e.g., crest factor≈1.1) and long effective contact electrification time. In certain embodiments, based on the direct current characteristics, energy harvested from rainwater can be fed directly to electronic devices and a self-powered rainfall sensor can also be implemented. Embodiments of the subject invention provide all-liquid systems useful in applications including distributed green energy, passive sensors, and other self-powered devices.

IPC Classes  ?

• H02N 1/04 - Friction generators

Abstract

The subject invention pertains to a new class of compounds, N-acryloylindole (NAIs), and methods of using NAIs as cysteine-reactive probes for proteome-wide cysteine profiling and imaging of thiol oxidative modifications. NAIs are capable of imaging oxidized thiols in cells facing oxidative stress by confocal fluorescence microscopy. NAIs can capture populations of cysteines, particularly those involved in gene expression and regulation.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07D 209/08 - IndolesHydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A system for the rectification of batch-induced distortions and the extraction of phenotypic attributes from biological images is presented. This system encompasses a deep-learning generative adversarial network model, expertly tailored to converse with and modify the contrast of input images, resulting in the creation of output images. A discriminator, operating as a feedback mechanism, discriminates the output image against the input image, ensuring precise image contrast conversion. Integral to this system is a morphology distillator, having a dual classifier framework comprising a batch classifier and a cell type/state classifier. This distillator adeptly identifies phenotypic characteristics and batch-related disparities, subsequently eradicating these batch variations from the output image. The resultant augmentation enriches the cellular information within the image.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 5/00 - Image enhancement or restoration
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

Systems and methods for improving magnetic resonance imaging relate to reconstructing multi-slice images based on sharing the strong structural similarities between adjacent image slices. In addition, a joint denoising method exploits these structural similarities. In part the reconstruction is based on use of a residual neural networks and denoising is achieved with a deep learning based strategy. The system and method have proved useful in both simulation and in vivo brain experiments, demonstrating significant noise reduction in all images and revealing more microstructural details in quantitative diffusion maps.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06T 7/00 - Image analysis
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

The present invention relates to a method for assessing respiratory viral infections, the method includes preparing one or more precision-cut human bronchial tissues; exposing a cilia-rich epithelium within the precision-cut human bronchial tissues to establish an ex vivo model of human bronchus for viral infections; assessing infectivity, tropism, and pathogenesis of one or more respiratory viruses in the ex vivo model; and providing a semi-quantitative and normalized approach to supplement data from the ex vivo model of human bronchus for pandemic risk assessment of the one or more respiratory viruses. The present invention involves micro-dissection of bronchial tissues to expose the cilia-rich epithelium for ex vivo virus infection, along with a semi-quantitative approach for analyzing virus tropism and replication competence.

IPC Classes  ?

• G01N 33/52 - Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• G01N 1/28 - Preparing specimens for investigation

Abstract

Disclosed is a passivated perovskite structure containing a perovskite layer; and a hindered urea bond-based Lewis acid-base containing layer adjacent the perovskite layer. Also disclosed are solar cells containing the passivated perovskite structure.

IPC Classes  ?

• H10K 30/50 - Photovoltaic [PV] devices
• C07C 333/20 - Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

Compositions and methods for early diagnosis, risk stratification, and effective management and treatment of patients with hepatocellular carcinoma are provided. The compositions and methods selectively target S100A10, for effective detection of S100A10 in a subject, for example, from plasma samples or from tissue biopsy, and for effective inhibiting and/or reducing the activities and/or quantities of S100A10 in vitro and/or in vivo. Methods for selecting patients who would be amenable for the disclosed therapies and for treating such patients are also described.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12Q 1/6851 - Quantitative amplification
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer