Abstract

A dendritic cell (DC)-targeting M13 phage vaccine platform is provided herewith, where spy-tagged neoantigens can be attached to the phage surface with spy-catchers. By expressing DC-targeting peptides and spy-catchers as foreign antigens on the phage surface, its therapeutic and antigenic properties can be enhanced to combat solid cancers. SLS-spy catcher phage (SCP), with or without neoantigen conjugation, significantly repressed tumour growth by boosting systemic anti-tumour immunity and increasing intratumoral infiltration of both innate and adaptive immune cells. Intratumoral administration of SCP also hugely reduced PDL1 expression on tumour cells, making them more susceptible to immune attacks. Additionally, SCP administration restricted the size of blood vessels inside the tumour mass, suggesting multiple factors contribute to restrict tumour growth.

IPC Classes  ?

• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

Disclosed is a novel compound 5-(3,4-difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263, Compound 1), its derivatives, composition comprising the compound and method to effectively relieve nerve injury-induced neuropathic pain. Also disclosed are methods of treating diseases or disorders associated with the voltage-gated sodium channels. The disclosed methods may be utilized to treat diseases or disorders associated with pain in a subject, including nociceptive pain, chronic pain, neuropathic pain, and inflammatory pain. Also disclosed are inhibitors that specifically inhibit voltage-gated sodium channel function in a state-dependent manner. The disclosed compounds may also be used in pharmaceutical compositions and methods for treatment of pain associated with voltage-gated sodium channel activity.

IPC Classes  ?

• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4245 - Oxadiazoles
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

The system includes an operator terminal, a robot terminal, and a tele-robot control protocol (TRCP) server for managing data transmission. The operator terminal comprises an input device to receive operator commands, a visualization device for stereoscopic feedback, a haptic device for tactile feedback, a command generation module, and a feedback processing module. The command generation module generates control commands and waits for confirmation from the feedback processing module before issuing new commands. The robot terminal includes a robotic arm, a command execution module, a force sensor, a camera, and a feedback generation module. The command execution module converts received commands into machine-readable signals for the robotic arm and extracts event reference values. The feedback generation module processes data from the force sensor and camera, appending event reference values to feedback before sending it to the operator terminal.

IPC Classes  ?

• H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network

Abstract

This invention provides a coin-sized, fully integrated and wearable continuous glucose monitoring system (CGMs) via combining cutting-edge technologies from the intersecting fields of biosensors, minimally invasive tools, and hydrogels. The invention includes three major parts: 1) an emerging biochemical amplifier, the organic electrochemical transistor (OECT), to improve sensitivity beyond traditional electrochemical modules; 2) a microneedle array for interstitial-fluid (ISF) sampling with reduced pain during skin penetration; and 3) a tough, adhesive enzymatic-hydrogel-membrane to enhance reliability of glucose sensing on skin. Unlike conventional CGMs, the employed OECT amplifier empowers the CGM (OECT-CGMs) with a high anti-noise ability, an on-demand-tunable sensitivity and current regeneration ability, enabling long-term stable glucose sensing within specific clinical ranges (1˜20 mM). This work paves the way for the development of next-generation CGMs that can simultaneously deliver high and adjustable sensitivity, minimal invasiveness, and improved wearability.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61L 31/14 - Materials characterised by their function or physical properties
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The invention provides computer-implemented method and system for mediating a robot-centric data schema to a building-centric data schema for representing a robot is provided. The building-centric data schema represents the robot with a plurality links representing non-deformable parts of the robot and a plurality of joints describing relationship between the links. The method comprises: extracting robot information from the robot-centric data schema; creating a robot container to model the robot as a whole-part structure; translating the plurality of links and the plurality of joints from the robot-centric data schema to the building-centric data schema based on the extracted robot information; filling the robot container with the translated links and translated joints; and constructing the building-centric data schema with the robot container filled with the translated links and translated joints.

IPC Classes  ?

• B25J 9/16 - Programme controls
• G06F 40/205 - Parsing

Abstract

A moving object detection system and method is provided. The system includes an input module capturing a point cloud comprising measurements of distances to points on one or more objects and a detection module receiving the point cloud captured by the input module and configured to determine whether the objects are moving objects. The determination of moving objects is performed by determining whether currently measured points occlude any previously measured points, and/or whether the currently measured points recursively occlude any previously measured points, and/or whether the currently measured points are recursively occluded by any previously measured points.

IPC Classes  ?

• G05D 1/242 - Means based on the reflection of waves generated by the vehicle
• G05D 1/633 - Dynamic obstacles

Abstract

A hoisting posture control system and method, applicable to the technical field of modular construction. According to the hoisting posture control system, controllers corresponding to functional modules are called on the basis of data detected by sensors, to drive posture control of a hoisted object, thereby assisting a tower crane operator in making work decisions, so that the operator does not need to take risks to get close to a module to be installed hoisted in the air, ensuring the safety of workers and the accuracy and reliability of module installation. Thus, the labor cost in modular construction work can be reduced, and the assembly quality and efficiency of modules are improved.

IPC Classes  ?

• B66C 13/08 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for depositing loads in desired attitudes or positions
• B66C 13/06 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for minimising or preventing longitudinal or transverse swinging of loads
• B66C 13/48 - Automatic control of crane drives for producing a single or repeated working cycleProgramme control
• B66C 13/16 - Applications of indicating, registering, or weighing devices
• B66C 1/12 - Slings comprising chains, wires, ropes, or bandsNets

Abstract

A hoisting position and posture adjustment system and a hoisting apparatus. The hoisting apparatus comprises the hoisting position and posture adjustment system, wherein the hoisting position and posture adjustment system comprises a posture adjustment device (20), a hoisting frame (11), a horizontal-displacement adjustment device (13) and a lifting spreader (12) which are sequentially arranged in a vertical direction, the lifting spreader (12) being connected to the hoisting frame (11) or the horizontal-displacement adjustment device (13) and configured to connect to a hoisted object (300); the horizontal-displacement adjustment device (13) is connected to the hoisting frame (11) and is configured to adjust the horizontal position of the hoisted object (300); and the posture adjustment device (20) is connected to the hoisting frame (11) and is configured to adjust the posture of the hoisted object (300), so as to keep the hoisted object (300) in a horizontal posture. By means of the cooperation of the horizontal-displacement adjustment device and the posture adjustment device, the hoisting position and posture adjustment system of the present application can automatically fine-tune the position and posture of a hoisted object, such that the amount of manual participation can be significantly reduced, thereby facilitating a reduction in labor costs and safety risks; moreover, the hoisted object can be accurately placed at a target position, thereby reducing the dependence on workers.

IPC Classes  ?

• B66C 13/08 - Auxiliary devices for controlling movements of suspended loads, or for preventing cable slack for depositing loads in desired attitudes or positions
• B66C 1/12 - Slings comprising chains, wires, ropes, or bandsNets

Abstract

Provided is in the field of immunology. Provided are broadly neutralizing antibodies against SARS-COV-2 variants, compositions and methods of prevention and treatment of SARS-COV-2 infection or transmission.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• C12N 15/13 - Immunoglobulins
• G01N 33/577 - ImmunoassayBiospecific binding assayMaterials therefor involving monoclonal antibodies
• A61K 39/42 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum viral
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Supramolecular nanostructures having spatially distinct features and methods for the preparation of such nanostructures are disclosed. The supramolecular nanostructures are composed of planar, or linear small molecules associated with each other through non-covalent interactions including, but not limited to, metal-metal interactions, π-π interactions, hydrogen bonding interactions, solvophobic-solvophobic interactions, or a combination thereof, and polymer components stabilized by non-covalent interactions. These supramolecular nanostructure materials can exhibit a wide variety of functional properties due to the two chemically diverse components, in which a great flexibility and a large variety of choices are available, enabling options to control the supramolecular nanostructure's luminescence properties and compositions.

IPC Classes  ?

• C08K 5/56 - Organo-metallic compounds, i.e. organic compounds containing a metal-to-carbon bond
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Abstract

A stretchable, conducting, and redox-active hydrogel with an interpenetrating double-network structure is provided. This structure is formed by infiltrating a brittle pure-gel conducting hydrogel with a stretchable hydrogel. Ferrocene derivatives are immobilized on the chains of the stretchable hydrogel through covalent bonds, and glucose oxidases are crosslinked to the stretchable hydrogel using a room-temperature crosslinker.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 11/04 - Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Abstract

A flexible micro-needle electrode for biopotential monitoring, a method for constructing the flexible micro-needle electrode and a patch electrode comprising the flexible micro-needle electrode. The method comprises the steps of providing a negative stamp that has been structured with a plurality of micro-needle structures; depositing at least one layer of electrically conductive material onto the negative stamp; and peeling off the at least one layer of electrically conductive material from the negative stamp to obtain the flexible micro-needle electrode comprising the at least one layer of electrically conductive material defined with the plurality of micro-needle structures.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/262 - Needle electrodes

Abstract

A hot stamping method for pre-coated steel plate comprises performing a preliminary heat treatment on the pre-coated steel plate before hot stamping. The preliminary heat treatment comprising: (1) a step of heating and temperature holding involving: heating the pre-coated steel plate to 850-920° C. and holding the temperature for 7 to 15 minutes, or heating to 920-960° C. and holding the temperature for 5 to 10 minutes; (2) cooling the pre-coated steel plate to below 300° C. after the step of heating and temperature holding at a cooling rate not less than 5° C./s; and (3) optionally repeating the step of heating and temperature holding and the step of cooling one or more times. The preliminary heat treatment increases the alloying degree of the pre-coating layer, reduces the carbide structures in the steel plate matrix, and obtains a martensite and/or bainite matrix structure, so as to reduce damage to a stamping die.

IPC Classes  ?

• B21D 22/02 - Stamping using rigid devices or tools

Abstract

A devices and systems for removing dental plaque/oral biofilms from a target surface or all surfaces of a tooth contains a socket head, a socket ball, and a pair of opposing bilateral wings. The socket ball is mounted in a joint-housing of the socket head, forming a ball-and-socket joint. The bilateral wings are connected to the socket head and extend downwardly. Each wing may include one or more cleaning elements, such as water cannons, water cannon folds, mega-/micro-nipples, and/or mega-/micro-nipple coupled water cannons. A system containing the device typically includes one or more additional components configured to incorporate the device into an element for user operation and link the device to a flow path, providing a fluid/air flow path for supplying a liquid and/or air to the device.

IPC Classes  ?

• A61C 17/02 - Rinsing or air-blowing devices, e.g. using fluid jets

Abstract

A biological network mimic for investigating subcellular structures and their interaction with biomolecular condensates is presented. The mimic is a stimulus-responsive polymer and a non-responsive polymer in an aqueous two-phase system (ATPS). One effective mimic is an aqueous two-phase system (ATPS) that combines poly (N-isopropylacrylamide) (PNIPAM) and dextran (DEX). The ATPS mimic, displays ultrasensitive thermo-induced aqueous liquid-liquid phase separation and liquid-solid phase separation (AqLL-LS PS2). Diverse structures, including networks, hollow spheres, and spinodal decomposition-like patterns, are generated by regulating component concentrations and temperatures. These structures are thermally reconfigurable. Networks can melt fused in sarcoma (FUS) condensates. The mimics provides methods to examine potential treatments of neurode-generative diseases by dissolving pathologically relevant biomolecular condensates.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C08L 5/02 - DextranDerivatives thereof
• C08L 33/24 - Homopolymers or copolymers of amides or imides
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

Disclosed are methods and materials for treating a subject having hepatocellular carcinoma (HCC). The methods and materials are useful, for example, for conversion of locally advanced, unresectable HCC. For example, the disclosed methods and materials are useful for conversion of locally advanced, unresectable HCC. The methods generally include sequential combination of three treatments: transarterial chemoembolization (TACE); stereotactic body radiotherapy (SBRT); and immunotherapy with an immune checkpoint inhibitor.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61N 1/40 - Applying electric fields by inductive or capacitive coupling
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Described herein are heterogeneous catalysts and methods of making and using thereof. For instance, heterogeneous catalysts formed of bisphosphine-ligated copper(I) complexes on a metal-organic framework support can be used, for example, in cycloaddition reactions.

IPC Classes  ?

• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 35/39 - Photocatalytic properties
• B01J 37/00 - Processes, in general, for preparing catalystsProcesses, in general, for activation of catalysts

Abstract

Provided herein is a photoresponsive prodrug comprising an active agent conjugated to a photoresponsive group, and a nanoparticle, wherein the photoresponsive prodrug is co-assembled with a polymer to form a nanoparticle. Also provided is a method of treating a subject, comprising administering photoresponsive prodrug or the nanoparticle to the subject, and irradiating at the target site with a light source.

IPC Classes  ?

• A61K 31/69 - Boron compounds
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

A method and systems for quantifying and calculating window view openness indexes based on window view photos and view distances are provided. The method includes generating a window view image by an image capturing device; computing a distant view layer proportion; measuring and computing a close-range view layer distance; computing a view distance-based openness adjustment factor (OAF); and computing a window view openness index (WVOI). The computing of a distant view layer proportion may include extracting a proportion of a distant layer of the window view image as a basic factor to measure view openness. The OAF is summarized from view distances computed in the step of measuring and computing a close-range view layer distance. The WVOI is calculated based on the proportion of distant view layer and the OAF from the close-range view layer distance.

IPC Classes  ?

• G06T 11/00 - 2D [Two Dimensional] image generation
• G06T 7/50 - Depth or shape recovery

Abstract

Provided in the present invention are an anode for a PEM water electrolytic cell and a preparation method for the anode. The anode comprises a stainless steel base body and a layered oxide structure generated on the surface of the stainless steel base body in situ, wherein the layered oxide structure comprises a manganese-deficient inner layer and a manganese-rich outer layer, the manganese-rich outer layer comprising a crystal manganese oxide secondary outer layer and an amorphous iron-containing manganese oxide outermost layer. The layered oxide structure of the surface of the anode of the present invention can maintain long-time catalytic activity for electrolysis of water and stability under acidic conditions, and an appropriate surface structural component selection solves the problems of corrosion and stability of self-catalysis and non-noble metal electrodes in an acidic environment. The anode provided in the present invention significantly reduces the present cost of hydrogen production based on a noble metal catalyst, and is expected to solve high-cost problem of PEM large-scale electrolysis hydrogen production.

IPC Classes  ?

• C25B 11/053 - Electrodes comprising one or more electrocatalytic coatings on a substrate characterised by multilayer electrocatalytic coatings
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25C 7/02 - ElectrodesConnections thereof

Abstract

A method of fabricating a crack-free anionic network polymer (ANP) electrolyte membrane by conjugating anionic nodes (Monomer-Cl) with a short alkene possessing a C═C (carbon double bond) terminal group to form a structure with alkene moieties, mixing the modified anionic nodes with an ionic conductive polymer linker in organic solvent and exposing the mixture to ultraviolet (UV) light to triggers a polymerization process via click reaction to form a crack-free anionic network polymer carbon double bond (ANP-C) membrane. Forming a lithium battery from the membrane when the anionic nodes are lithium tetrakis 4-(chloromethyl)-2.3.5.6-tetrafluorophenyl) borate and the short alkene is 5-hexenol.

IPC Classes  ?

• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates

Abstract

Pharmaceutical composition for treatment of HIV-1 infection comprising nicotinamide mononucleotide (NMN) as active ingredient. And use of NMN for preparation of medicament.

IPC Classes  ?

• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• C07H 19/048 - Pyridine radicals
• A61P 31/18 - Antivirals for RNA viruses for HIV

Abstract

Compositions, kits and methods of determining the presence of nasopharyngeal carcinoma (NPC) in a subject or relapse prediction of NPC in the subject are provided, with high specificity, sensitivity, and accuracy. Exemplary mutations include mutations in EMP2, IL32, EEF2KMT, CSTA, SOCS1, TESMIN, and IGFBP7 can be used to detect NPC. Mutations in IL32, DHX57, HMGN2P3, DNAJC11, EIF2AK1, FAM234A, PARPBP, ARL5A, ATPAF1, HDAC2, TACSRD2, and/or LMO4 used to achieve NPC relapse prediction. The analyte to be detected can be either RNA or protein, peptide, or fragment thereof etc. can detect NPC. High level of LY6D-positive neoplastic cells, neoplastic SPB cells reflected by RNA/protein expression of KRT16, CEBPD, CDKN1A, PGM2, and LY6D, neoplastic SPB1, SPB2 cells neoplastic SPB5 cells HDAC-mutated neoplastic SPB1 cells ATPAF1-mutated neoplastic SPB1, and low level of non-neoplastic SPB cells, non-neoplastic SPB1, and high neoplasticity of SPB cells can be used for NPC relapse prediction.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C12N 15/12 - Genes encoding animal proteins
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The subject invention pertains to methods of derivation of MSCs from both human or other mammal iPSCs and embryonic stem cells (ESCs) via a temporal induction of neural ectoderm in chemically defined media. In certain embodiments, the methods use a two-stage culture.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells

Abstract

An automatic system which combines a three-branch sorter with three independently-controlled valves and corresponding collection platforms. The subgroups of droplets are alternatively sorted into three channels followed by being pumped out into PCR tubes on the platforms. Experimentally, this system can realize an accurate collection with a large working range for both pure positive samples and mixed samples with negative ones. This technology effectively dispenses a large number of droplets into small subgroups with quantitative number, which builds the basis for digital droplet microfluidics.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/149 - Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
• G01N 15/1492 - Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties within droplets
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Disclosed is a method of treating cancer in a subject using cyclin-dependent kinases 4/6 inhibitors such as abemaciclib. In particular, the subject carries specific diffuse type driver pathway alterations including ARHGAP fusion and CDH1 mutation. In particular, the cancer is gastric cancer. Also provided is a system for testing drug sensitivity using gastric cancer organoid and the use of the system to identify biomarkers predicting sensitivity to CDK4/6 inhibitors in gastric cancer.

IPC Classes  ?

• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61P 35/00 - Antineoplastic agents

Abstract

A method for cancer diagnosis and treatment. In particular, in identifying associations between biomedical markers which is indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular nasopharyngeal cancer (NPC) metastasis after radiation therapy. The biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably radiation therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, or all markers selected from CXCR6, ASPHD2, DDX39B and AGAP9. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular nasopharyngeal cancer, is provided, as well as a corresponding method for classifying a subject and a medical decision support system.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

A method and apparatus for forming vascular-like channels involves liquid-in-liquid 3D printing utilizing two polymer solutions used as a printing ink and a matrix. Anionic polyacrylamide (APAM) is one of the polymer solutions and acts as the matrix material. Chitosan is the other polymer solution and acts as the printing ink. The chitosan printing ink is extruded through a print nozzle of a 3D printer onto the APAM matrix which covers the bottom of a petri dish while the nozzle is moved in a desired pattern for the channels. The chitosan and APAM polymer complexes self-assemble on the ink-matrix interface, locking chitosan polymers inside the matrix before they can spread and causing the formation of soft elastic membranous walls. The chitosan ink and APAM matrix can be removed after the polymer complex self-assembly. The printed chamber with membranous walls allows for liquid infusion to work as fluidic channels.

IPC Classes  ?

• B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
• B29C 64/209 - HeadsNozzles
• B29K 33/00 - Use of polymers of unsaturated acids or derivatives thereof, as moulding material
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• B33Y 80/00 - Products made by additive manufacturing
• C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide

Abstract

Cyclometalated iron (II) complexes as photothermal transduction agents are described herein. The disclosed complexes show high structural robustness and significant absorption in the near-infrared (NIR) and visible regions. The described complexes can self-assemble to form metallosupramolecular particles, which have excellent photothermal performance and can target tumor by EPR effect. For example, the Fe NPs disclosed herein have strong near-infrared (NIR) absorbance with high photo-heat conversion efficiency of at least 30% (such as about 60%) and/or superior photothermal stability under near-infrared (e.g., 808 nm) laser irradiation. The Fe NPs may be coated with a coating agent, such as bovine serum albumin, to form a coated Fe NPs, which can further enhance the tumor accumulations and biocompatibility of the metallosupramolecular particles in vivo. The excellent photothermal performance of the Fe NPs allow them to solve the problem of low photothermal conversion efficiency associated with most existing photothermal materials.

IPC Classes  ?

• C07F 15/02 - Iron compounds
• A61K 33/26 - IronCompounds thereof
• A61N 5/067 - Radiation therapy using light using laser light

Abstract

An agent for an arrest of dental caries is a silver complex fluoride (SCF) of the structure: [Ag(1,3,5-triaza-7-phosphaadamantane)2]F, (Ag(PTA)2F). The agent effectively arrests dental caries and promotes remineralization of carious lesions. The agent results in minimal staining of teeth and tissue inflammation. The therapeutic agent can be applied selectively to a site of caries or other damaged tissue in the oral cavity.

IPC Classes  ?

• C07F 9/6584 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
• A61K 8/19 - Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• A61K 8/21 - FluoridesDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 33/16 - Fluorine compounds
• A61K 33/38 - SilverCompounds thereof
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

A droplet gripper for a polarizable droplet including a top plate formed of magnetically responsive material and movable in a defined sequence in response to a regionalized electromagnetic field. The gripper further has electret sheets downwardly depending from the top plate. The electret sheets are separated from each other and are chargeable to the same polarities so as to capture the droplet between them due to electret-induced polarization on droplet (EPD). The gripper may be included in a Multiphysics droplet robotic system for automatically manipulating and moving a liquid droplet. The system includes a programmable control matrix that generates a movable regionalized electromagnetic field through coils so as to engage the magnetic material on the top plate and move the EPD gripper and a captured polarizable drop in the defined sequence along a specific path as well as to achieve other microfluidic operations according to a control matrix program.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A series of highly rigid and highly luminescent cyclometalated tetradentate ligand-containing gold (III) compounds is designed and synthesized. The cyclometalated tetradentate ligand-containing gold (III) compounds can be used as light-emitting material for fabrication of light-emitting devices. The cyclometalated tetradentate ligand-containing gold (III) compounds can be deposited as a layer or a component of a layer using a solution-processing technique or a vacuum deposition process. The cyclometalated tetradentate ligand-containing gold (III) compounds are robust and can provide electroluminescence with high efficiency and brightness. More importantly, vacuum-deposited OLEDs demonstrate high operational stabilities with long operational half-lifetimes of over 188,000 hours at 100 cd m-2.

IPC Classes  ?

• C07F 1/12 - Gold compounds
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H05B 33/14 - Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the electroluminescent material

Abstract

Described herein are a novel concept of thermally stimulated delayed phosphorescence (TSDP) to harvest light emission from the higher energy triplet excited state via the up-conversion from the lowest-energy triplet excited state by efficient spin-allowed reverse internal conversion as well as the development of TSDP emitters, as exemplified by a novel class of gold(III) compounds with TSDP properties and methods of making and using said compounds. The gold(III) compound includes a triazine-containing cyclometalating tridentate ligand and one auxiliary ligand, both coordinated to a gold(III) metal center. The gold(III) compounds disclosed herein can be used as light-emitting material for fabrication of OLEDs.

IPC Classes  ?

• H10K 50/12 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers comprising dopants
• H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
• H10K 71/16 - Deposition of organic active material using physical vapour deposition [PVD], e.g. vacuum deposition or sputtering
• H10K 85/30 - Coordination compounds
• H10K 101/20 - Delayed fluorescence emission

Abstract

The present invention relates to methods for predicting the recurrence risk of hepatocellular carcinoma (HCC). Specifically, it proposes a deep learning model capable of integrating information from different phases of CT images and clinical data to predict the risk of HCC recurrence within 1 to 5 years after treatment. Experimental results demonstrate that these models outperform traditional prediction methods based on histological microvascular invasion (MVI) in predicting HCC recurrence risk.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G06T 7/00 - Image analysis

Abstract

Provided is a system for drug delivery utilizing hydrogel to deliver biologically active agents to stimulate mature intratumoral tertiary lymphoid structure formation and augment immune check point blockade. Provided herein is an injectable hydrogel that can stimulate the formation of immune structures within tumors, improving cancer prognosis and treatment response. Provided is a method of treating cancer. Also provided is a method of making the drug delivery system.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/19 - CytokinesLymphokinesInterferons
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Described is a computer-implemented system (CIS), a computer-implemented method (CIM), and/or or machine learning algorithm (MLA) that generates anatomically site-specific advice on topical anatomy healthcare, such as oral hygiene care based on images initially generated using a mobile phone (e.g., a smart phone) or other hand-held devices. The CIS, CIM, or MLA contains a generative artificial intelligence (AI) platform operably linked to a graphical user interface (GUI) and a discriminative AI platform. The discriminative AI platform generates topical, anatomical images contain the state of health of specific sites on the anatomy, while the generative AI platform generates anatomically site-specific health-based advice based on the image generated by the discriminative AI platform, and transmits the advice to the GUI. The disclosed CIM, CIS, or MLA provides new platforms that utilize AI to provide, automatically and instantaneously, personalized oral hygiene care.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

The present invention relates to a SDFAST (Self Dilution for Faster Antimicrobial Susceptibility Testing), which is a microfluidic device that can perform self-dilution and does not require any pumps or valves to accomplish multiplexed microfluidic processes. SDFAST is designed using AutoCAD and fabricated using micro-milling machine. It consists of two polymethyl methacrylate (PMMA) rectangular plates which are in contact throughout the operation. The first plate is the bottom one that serves as lines of wells. The second plate is the top one that acts as a lid and seals the system. The second plate has complementary designs that echo the wells in the first plate, which allows fluidic channels to be formed.

IPC Classes  ?

• C12Q 1/20 - Testing for antimicrobial activity of a material using multifield media
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A method of ligand-induced regional modification of a perovskite film of perovskite optoelectronic device can include generating a ligand atmosphere, exposing a perovskite optoelectronic device in the ligand atmosphere, and removing the perovskite optoelectronic device from the ligand atmosphere. Methods for improving the performance and stability of perovskite optoelectronic devices are performed by using a ligand-induced modification of complete devices at room temperature. This post-device treatment, completely separated from the fabrication process of common perovskite optoelectronic devices, provides a general strategy to improve the stability of different completed perovskite optoelectronic devices (i.e., perovskite solar cells, perovskite light-emitting diodes, and photodetectors) without introducing any undesirable impurities during device fabrication.

IPC Classes  ?

• H01G 9/20 - Light-sensitive devices
• C07F 7/24 - Lead compounds
• H01G 9/00 - Electrolytic capacitors, rectifiers, detectors, switching devices, light-sensitive or temperature-sensitive devicesProcesses of their manufacture
• H10K 30/30 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains
• H10K 30/81 - Electrodes
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
• H10K 85/30 - Coordination compounds

Abstract

A hot end (16) for a fused deposition modeling (FDM) printer has two entrances for low-fluidity materials that may differ from each other by color and/or structure. Two separate channels (21a, 21b) of the hot end (16) lead from the entrances to a common end at a central tube (25). The two channels (21a,21b) are in the form of two special angle-skewed tubes that meet at their ends and that narrow gradually from the extruders (19') toward their ends. The central tube (25) extends from the ends of the channels (21a, 21b) to an nozzle (26). An SK type static mixer (24) is located in the central tube (25) and a heating unit (11) surrounds the hot end (16). A controller (15) operates the two extruders (19') that supply the low-fluidity materials to the two entrances of the hot end (16) in such a way as to produce ceramic (e.g., zirconia) objects that have 3D color and structural gradients.

IPC Classes  ?

• B28B 1/00 - Producing shaped articles from the material
• B29C 64/209 - HeadsNozzles
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor

Abstract

Disclosed is an anti-caries compound, composition with antimicrobial and/or remineralizing properties and methods of using the compound and composition. The anti-caries compound is synthetic peptide Gallic-Acid-Polyphemusin-1 (GAPI) that is useful to manage dental hygiene and oral infections. Method of making a highly stable and purified form of GAPI is also disclosed. Also disclosed are the minimum inhibitory concentration and minimum bactericidal concentration against common oral pathogens.

IPC Classes  ?

• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61K 8/368 - Carboxylic acidsSalts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61P 31/04 - Antibacterial agents
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

A vapor deposition system is described. The vapor deposition system includes a reaction chamber and a reactant delivery subsystem coupled with the reaction chamber. The reaction chamber is configured to retain a substrate therein. The reactant delivery subsystem includes inlets, a pre-reaction region, and outlets. The inlets receive precursors and chalcogen precursor(s). The pre-reaction region is configured to receive the precursors from a portion of the inlets and to react at least a portion of the precursors to form modified precursor(s). The modified precursor(s) are more thermally stable than metal-containing precursor(s) of the precursors used to form the modified precursor(s). The outlets are coupled with the reaction chamber and the pre-reaction region. The outlets separately provide the modified precursor(s) and the chalcogen precursor(s) to the reaction chamber. The modified precursor(s) and the chalcogen precursor(s) react and form a chalcogen film on the substrate in the reaction chamber.

IPC Classes  ?

• C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber

Abstract

Provided is a drug delivery system comprising an ophthalmic composition for administration. The composition comprises nanoparticles comprising a core and an outer surface. The core comprises drugs and a carrier and the outer surface comprises a membrane derived from an ocular tumor cell. Also provided is a method of treating an ocular disease or condition using the nanoparticles. Also provided is a method of making the drug delivery system.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61P 27/02 - Ophthalmic agents

Abstract

A vapor deposition system is described. The vapor deposition system includes a reaction chamber and a reactant delivery subsystem coupled with the reaction chamber. The reaction chamber is configured to retain a substrate therein. The reactant delivery subsystem includes a inlets, a pre-reaction region, and outlets. The inlets receive precursors and chalcogen precursor (s). The pre-reaction region is configured to receive the precursors from a portion of the inlets and to react at least a portion of the precursors to form modified precursor (s). The modified precursor (s) are more thermally stable than metal-containing precursor (s) of the precursors used to form the modified precursor (s). The outlets are coupled with the reaction chamber and the pre-reaction region. The outlets separately provide the modified precursor (s) and the chalcogen precursor (s) to the reaction chamber. The modified precursor (s) and the chalcogen precursor(s) react and form a chalcogen film on the substrate in the reaction chamber.

IPC Classes  ?

• C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
• C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
• H01L 31/032 - Inorganic materials including, apart from doping materials or other impurities, only compounds not provided for in groups

Abstract

A method of integrating a solution-processed transparent electrode based on a metallic nanowire network and polymers is provided. The method includes forming at least one metallic network on an underlying substrate via a solution process comprising a plurality of metal nanowires and a plurality of junctions where the metal nanowires meet; forming a gap filling layer on the metallic network to form a complex of metallic network and polymer; and drying the complex of metallic network and polymer, wherein the metallic network and polymer are connected to each other at least by chemical bonding.

IPC Classes  ?

• H01B 13/00 - Apparatus or processes specially adapted for manufacturing conductors or cables

Abstract

Provided are methods and compositions for treatment, screening, diagnosis and prognosis of hepatocellular carcinoma with extrahepatic metastasis. Provided herein are methods and compositions for treatment, screening, diagnosis and prognosis of metastatic cancers. Also provided are monoclonal antibodies and compositions for the treatment of cancers. Provided herein is therapeutic target for the treatment of cancers or as a marker for cancers.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

A method for detecting sCDCP1 in a bodily fluid of a subject, wherein the subject is selected for early pharmacological and/or lifestyle intervention for nonalcoholic steatohepatitis (NASH), when: (a) the level of sCDCP1 detected in the bodily fluid of the subject is elevated compared to the average level of sCDCP1 in the bodily fluid of subjects not suffering from NASH and/or (b) a numerical score calculated by using the level of sCDCP1 in an algorithm is elevated compared to the numerical score calculated by using the average level of sCDCP1 in the bodily fluid of subjects not suffering from NASH in the algorithm of sCDCP1. A method for treating a subject having NASH, comprising treating the subject with a therapy that reduces CDCP1 expression.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Provided are an integrated analysis method and apparatus for marking multimodal retinal ganglion cell (RGC) data of central nervous system cell aging. The method uses an aged RGC as a biomarker of the central nervous system cell aging, and comprises: applying an ETDRS grid to a reconstructed plan view of a macular region in an OCT retinal thickness image, so as to divide the plane view into a plurality of regions, wherein the OCT thickness image comprises thickness and volume data values of five different retinal layers; grouping the plurality of regions and determining the average thickness and volume data distribution of each region to measure the abundance of RGCs; using a posterior pole module to record an OCTA image and performing fine stratification to obtain a retinal microvascular change in the OCTA image; and obtaining 103 hexagonal mfERG reports where pERG and ETDRS grids have a same center at a macula. On the basis of the obtained information, the histological and functional analysis of the RGCs is combined with the precise position distribution and corresponding blood supply microvascular changes to provide a non-invasive early detection analysis module that reflects the health of the RGCs.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

RhoA inhibitors that can covalently bind RhoA are described herein. The disclosed RhoA inhibitors show improved inhibitory efficacy (i.e., an IC50 value down to about 400 nM). Further, the disclosed RhoA inhibitors can specifically bind RhoA over other GTPases, such as other Ras GTPases (e.g., K-Ras and N-Ras) and particularly other Rho GTPases (e.g., Cdc42 and Rac1). The combination of high RhoA inhibitory efficacy and high RhoA specificity of the disclosed RhoA inhibitors allow these compounds to show high cytotoxicity and anti-metastatic effects in cancer cells, with negligible toxicity in normal cells, in vitro and in vivo. Pharmaceutical compositions containing the RhoA inhibitors and methods of using the RhoA inhibitors or pharmaceutical composition thereof for treating cancer are also described.

IPC Classes  ?

• A61K 31/4155 - 1,2-Diazoles not condensed and containing further heterocyclic rings
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Methods for asymmetric cis-dihydroxylation (“AD”) of styrenes and conjugated dienes to produce cis-diols of styrene and conjugated diene or tetraols of conjugated diene with high yield (i.e., a yield ≥30%) and high enantioselectivity (i.e., an enantiometric excess ≥60%) are disclosed. The method uses an iron-based catalyst, such as one or more Fe(II) complexes, as the catalyst. The method generally includes: (i) maintaining a reaction mixture at a temperature for a period of time sufficient to form a product, where the reaction mixture contains a styrene or conjugated diene, one or more iron-based catalyst(s), an oxidant, and a solvent, and where the product contains a cis-diol or tetraol.

IPC Classes  ?

• B01J 31/22 - Organic complexes
• C07C 29/48 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups

Abstract

The present invention provides a method of simulating an intervertebral disc, comprising: automatically segmenting a medical image of a spine based on a pre-trained model so as to obtain different intervertebral disc segmentations; and biomechanical modelling under multiple motions for the different intervertebral disc segmentations so as to obtain dynamic properties of the intervertebral disc.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

Metallo-complex compounds and pharmaceutical compositions thereof are described herein. The metallo-complex compounds and pharmaceutical compositions can be use in treating infections in a subject in need thereof. The infections can be bacterial infections, such as multidrug resistant (MDR) bacterial infections.

IPC Classes  ?

• C07D 501/46 - Methylene radicals, substituted by nitrogen atomsLactams thereof with the 2-carboxyl groupMethylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atomQuaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
• C07D 501/00 - Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporinsSuch ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
• A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
• A61P 31/04 - Antibacterial agents

Abstract

A machine learning-based top variant identification pipeline method and systems for engineering genome editing proteins are provided. The method includes steps of performing zero-shot predictions by a zero-shot predictor together with a clustered-based sampling (CS) or Top regime method with wild-type (WT) being added to training data for low-N training data preparation; performing machine learning-assisted directed evolution (MLDE) predictions based on the training data prepared; and performing multi-round sampling of the CS/MLDE predictions, in which the wild type is added in a first-round sampling of the multi-round sampling. The zero-shot predictor is based on an arDCA method, an EVmutation method, an EvoEF method or a MSA method. The performance of the zero-shot predictor is evaluated based on performance metrics including Spearman's correlation (rho) and/or top 5% overlaps (overlap_5).

IPC Classes  ?

• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

Host-targeting antiviral agents against conserved phosphatidic acid phosphatase (PAP) pathways that act as broad-spectrum treatment strategies for different coronaviruses, such as variants of SARS-COV-2, have been developed. Compositions of anti-coronavirus agent(s) that acts via the host PAP pathway and methods of use thereof for treating and preventing diseases and disorders associated with coronaviruses are provided. An exemplary anti-coronavirus agent that acts via the PAP pathway is propranolol. Compositions of propranolol and methods of use thereof for treating and preventing diseases and disorders associated with coronaviruses are provided. In some forms, the compositions and methods treat or prevent one or more symptoms associated with infection by SARS-COV-2 wild type, Delta variants, Omicron variants and MERS-COV in a subject in need thereof.

IPC Classes  ?

• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/14 - Antivirals for RNA viruses

Abstract

Compositions including recurrent hepatocellular carcinoma (HCC) model generating systems are disclosed. The HCC model generating system contains a CRISPR-Cas expression vector, a transposase expression vector, and a transposon expression vector. Also provided is a non-human animal model of recurrent HCC containing genetic modifications introduced by integration of the model generating system into target liver cells of target animals. Upon stable integration, the model generating system modifies expression of Tp53 and expresses the oncogene in the target liver cells of the target animal, resulting in the development of a HCC tumors in the liver. Methods of using the non-human animal model of recurrent HCC are also provided. The non-human animal model of recurrent HCC can be used for research purposes such as investigating the molecular and genetic mechanisms underlying recurrent HCC tumor development, identifying potential therapeutic targets, and evaluating/screening potential compounds for the treatment of recurrent HCC.

IPC Classes  ?

• A01K 67/0278 - Knock-in vertebrates, e.g. humanised vertebrates
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed herein are vectors, synthetic antibodies, and methods of producing and using the same, comprising at least one polynucleotide sequence encoding an antibody or fragment thereof, wherein a variable heavy chain domain of the antibody or fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, and SEQ ID NO: 7, and a variable light chain domain of the antibody or fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, and SEQ ID NO: 8.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• A61K 39/42 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum viral
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus

Abstract

Provided is a method for compensating for loss in wave propagation, comprising: obtaining real frequency responses on the basis of a measurement result of wave propagation; selecting a complex frequency on the basis of the frequency of a wave and the dielectric constant of a medium so as to at least partially counteract the imaginary part of an in-plane wave vector in the wave propagation; and on the basis of a plurality of real frequency responses and the complex frequency, obtaining a complex frequency response to compensate for loss in the wave propagation.

IPC Classes  ?

• H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves

Abstract

The present invention relates to a welding assembly for packaging of a power semiconductor module. The welding assembly comprises: a first component, the outermost layer on a first side of the first component being a non-copper metal layer; a second component, a first copper layer being arranged on a first side of the second component; and a connecting copper layer, wherein two sides of the connecting copper layer are respectively connected to the non-copper metal layer and the first copper layer to form a first interface and a second interface, such that the first component and the second component are fixed together, and the average grain size of the connecting copper layer is in the range of 35-400 nm. The present invention further provides a welding assembly used for packaging of a semiconductor chip and relating to a plurality of components, and a method for producing the welding assembly for packaging of a power semiconductor module.

IPC Classes  ?

• H01L 23/492 - Bases or plates
• H01L 21/60 - Attaching leads or other conductive members, to be used for carrying current to or from the device in operation

Abstract

Described is a device for large-scale, high throughput, and rapid fabrication of microtissues. The device is designed as an invertible insert or a hanging insert, suitable for inversion and placement inside a single-compartment tissue culture plate. Further, the device has a three-dimensional support and contains a two-dimensional array of microwells with round-bottom cavities. The device facilitates the formation of multiple microtissues, including both cell aggregates and matrix-incorporated microtissues, through a single deposition process. Features of the device allow harvesting of microtissues via low-speed centrifugation.

IPC Classes  ?

• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C08J 5/18 - Manufacture of films or sheets
• C08L 89/00 - Compositions of proteinsCompositions of derivatives thereof

Abstract

The purpose of the present disclosure is to perform communication and channel estimation by using a multi-functional signal in a wireless communication system. A method for operating a first device may include the steps of: transmitting a first signal having a non-coherent detectable structure; transmitting first configuration information related to sounding to a second device; receiving a second signal on the basis of the first configuration information; transmitting second configuration information related to channel estimation to the second device; and transmitting a third signal to the second device on the basis of the second configuration information. The second configuration information is based on an antenna position of the second device, the antenna position being estimated on the basis of the first signal and the second signal, and may include a range of at least one basis vector included in a dictionary.

IPC Classes  ?

• H04L 27/26 - Systems using multi-frequency codes
• H04L 25/02 - Baseband systems Details

Abstract

A method for scalable fabrication of ultraflat polycrystalline diamond membranes, comprising: (1) growing a polycrystalline diamond membrane on a growth substrate having diamond seeds on the surface thereof using a chemical vapour deposition method; (2) cutting off at least a portion of the substrate after growth, forming a boundary at the cut where the polycrystalline diamond membrane is bonded to the growth substrate; (3) sticking a peeling tape; and (4) pulling the peeling tape to peel the polycrystalline diamond membrane off the surface of the growth substrate to expose the nucleation surface of the polycrystalline diamond membrane, wherein the exposed nucleation surface has a roughness less than the roughness of the grown surface. By flipping the nucleation surface of the grown polycrystalline diamond membrane, develops a novel and facile approach for fabricating affordable, scalable, ultraflat and transferable polycrystalline diamond membranes with great potential for practical applications.

IPC Classes  ?

• C23C 16/27 - Diamond only
• C23C 16/02 - Pretreatment of the material to be coated
• C23C 16/511 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using microwave discharges

Abstract

The present invention is for estimating a near-field channel in a wireless communication system. This method for operating a terminal may comprise the steps of: receiving first configuration information related to sounding from a base station; transmitting a sounding signal on the basis of the first configuration information; receiving second configuration information related to channel estimation from the base station; receiving a downlink reference signal from the base station on the basis of the second configuration information; and performing the channel estimation on the basis of the downlink reference signal.

IPC Classes  ?

• H04W 24/08 - Testing using real traffic
• H04B 17/373 - Predicting channel quality parameters
• H04L 5/00 - Arrangements affording multiple use of the transmission path
• H04W 72/23 - Control channels or signalling for resource management in the downlink direction of a wireless link, i.e. towards a terminal
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04B 7/08 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the receiving station
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

An interfacial plasmonic heating intensified IP reaction (IPH-IP) is used to fabricate highly permeable and selective polyamide RO membranes. Silver nanoparticles (AgNPs) are introduced to the IP reaction interface to serve as nano-heat generators under light illumination. The coupling of generated nano-heat rapidly promotes the interfacial temperature, thereby boosting the formation of extensively “nano-foamed” polyamide with prominent nanovoids and high crosslinking degree. These features enable the resulting RO membrane to achieve a superior combination of water permeance (3.4 L m−2 h−1 bar−1) and NaCl rejection (99.7%). This outstanding separation performance further enables the membrane to efficiently remove a wide spectrum of toxic contaminants frequently found in different water sources, revealing huge potential for various water treatment applications. In addition, the resulting RO membrane demonstrates efficient desalination of real seawater, producing clean water with high quality that far exceeds those of benchmarking commercial membranes.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 69/10 - Supported membranesMembrane supports
• B01D 69/14 - Dynamic membranes
• B01D 71/56 - Polyamides, e.g. polyester-amides

Abstract

The present disclosure is for acquiring channel information in a wireless communication system. An operation method of a terminal may comprise the steps of: receiving a first signal; generating information related to a channel by using the first signal; transmitting a second signal including feedback information related to the channel; and receiving a third signal transmitted on the basis of the feedback information. The feedback information includes information related to the distance between channel information and each portion of the first signal, and the first signal may have a structure supporting at least one operation among transferring information to another terminal and sensing an object.

IPC Classes  ?

• G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04B 7/0417 - Feedback systems
• G01S 7/292 - Extracting wanted echo-signals
• G01S 13/46 - Indirect determination of position data
• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications

Abstract

A method for enhancing characteristic signals by synthesizing multiple frequency waves is provided, which includes: obtaining real frequency responses based on the measurement results of spectral signals; selecting complex frequencies to at least partially compensate for spectral line broadening caused by losses; and obtaining complex frequency responses based on multiple real frequency responses and the selected complex frequencies to enhance the characteristic signals.

IPC Classes  ?

• H03L 7/16 - Indirect frequency synthesis, i.e. generating a desired one of a number of predetermined frequencies using a frequency- or phase-locked loop

Abstract

A two-dimensional spectrum recording apparatus has a source of collimated laser light impinging on a sample on a plate. The light passing through the sample forms an object wave and the light not passing through the sample forming a reference wave, which interfere with each other to form a holographic image at the plate. A beam splitter receives the collimated laser light from the sample and forms separate first and second light beams. A linear polarizer receives the first beam and passes it to a polarization camera having a Full Stokes mask. The camera records the light that passes through the Stokes mask. A slit aperture receives the second beam and transforms it into a slit of light that is applied to a diffraction grating. A diode array receives the second beam from the diffraction grating and forms a light spectrum that is recorded.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties

Abstract

The purpose of the present disclosure is to generate a multi-functional signal in a wireless communication system. This method for operating a device may comprise the steps of: generating information bits; generating at least one codeword by encoding the information bits; generating at least one symbol corresponding to at least a part of the at least one codeword; and transmitting the at least one symbol.

IPC Classes  ?

• H04L 27/34 - Amplitude- and phase-modulated carrier systems, e.g. quadrature-amplitude modulated carrier systems
• H04L 27/38 - Demodulator circuitsReceiver circuits

Abstract

The subject invention pertains to a novel poly(diallyldimethylammonium) fluoride (PDDAF) compound that provides a restorative material to arrest dental caries, remineralize carious lesions, and inhibit bacterial growth.

IPC Classes  ?

• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• A61K 8/84 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds
• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

Disclosed are polymersome nanoparticles that comprise a combination of drugs: (i) a ubiquitin-proteasome system (UPS) inhibitor; and (ii) a macropinocytosis inhibitor. Also disclosed is a method of treatment of cancer using the nanoparticles. Disclosed is a method of treatment of tumor having nutrient-deprived microenvironment, such as deficient in amino acids. The disclosure is directed to a combination of drugs for starvation of tumor cells comprising the use of nanoparticles which inhibits degradation of proteins in the tumor cells and prevents internalization of proteins into the tumor cells. Also provided are compositions and methods for affecting cell proliferation, metabolism or sensitization, including proteasome inhibitor therapy for the treatment of disease caused by deregulation of ubiquitin-proteasome systems, in a cell or subject.

IPC Classes  ?

• A61K 31/69 - Boron compounds
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 31/4965 - Non-condensed pyrazines
• A61P 35/00 - Antineoplastic agents

Abstract

The T-cell receptor (TCR) plays a crucial role in the adaptive immune response by recognizing specific antigens. In the context of cancer immunotherapy, TCR sequences can be engineered to target specific tumor antigens. In this study, hepatocellular carcinoma (HCC) was modeled in mice by combining genetic alterations recurrently observed in the human disease, and identified HCC-specific TCRs using single-cell TCR-seq. TCR convergence was observed across HCC-bearing mice, indicating that TCRs specific for HCC antigens elicit the expansion of CD4+ T cells. To further elucidate the function of this HCC-specific TCR, TCR-expressing vectors were designed and built, which can be used for various in vitro and in vivo applications, including identifying the specific peptide sequence that the TCR recognizes, manufacturing TCR-engineered T cells, studying T cell function, and screening potential immunotherapies. The findings have important implications for the development of T cell-based cancer immunotherapies.

IPC Classes  ?

• C07K 14/725 - T-cell receptors
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 35/00 - Antineoplastic agents
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

An electronic reader for electro-chemical transistors (OECT) includes a potential output control module that controls the Vd, Vs, and Vg for the OECT under test, a high accuracy current monitor module which contains a transimpedance amplifier (TIA) used to control the output voltage and convert the input channel current Ids into a voltage value. A microcontroller (MCU) that controls the working sequences of the TIA so as to realize the specific characterization mode and enable an adjustable output voltage range. The MCU further controls a programmable sampling rate of up to 200 k samples per second (SPS) with low noise by down-sampling the base rate, convolution processing it and interpolating it back to ah high frequency, but without the noise. The device is small enough to be worn by a user and its output is sent to a mobile device for reading.

IPC Classes  ?

• G08C 17/02 - Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
• G04G 21/04 - Input or output devices integrated in time-pieces using radio waves
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

The present invention provides a tensegrity joint comprising: a first inner structure having a first frame and a first strut extending orthogonally from the first frame; a second inner structure having a second frame and a second strut extending orthogonally from the second frame; at least three actuation tendons, each being fixed at a respective hole at the first frame and being guided and allowed to slide through a respective hole at the second frame; a central tendon connecting an apex of the first strut and an apex of the second strut such that the central tendon is in balance with the pulling forces exerted by the at least three actuation tendons; and an outer elastic protection sheath configured to wrap on a cylindrical surface between the first and second inner structures.

IPC Classes  ?

• B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
• B25J 9/16 - Programme controls

Abstract

The present invention relates to the technical field of construction waste treatment. Provided is an on-site intelligent sorting method for construction waste. The method comprises: S10, identifying waste components, and quantifying the proportion of inert material in construction waste; S20, by means of a computer vision method, acquiring visual difference features between the inert material and non-inert material; S30, performing mechanical screening, wherein the construction waste is screened by means of a mechanical screening module; S40, on the basis of precise sorting by a robot, performing detection on waste on a conveyor belt by means of waste detection driven by machine vision, then performing waste positioning, and, according to the results of waste detection and positioning, performing accurate sorting by using multiple robotic arms. The advantages of the present invention comprises: the described method is suitable for compact construction site scenes, the required space for installation and deployment is small, and an intelligent solution is provided for construction waste classification at compact sites.

IPC Classes  ?

• B07C 5/34 - Sorting according to other particular properties
• B07C 5/02 - Measures preceding sorting, e.g. arranging articles in a stream, orientating
• B07C 5/36 - Sorting apparatus characterised by the means used for distribution
• B07B 1/08 - Screens rotating within their own plane
• B07B 9/00 - Combinations of apparatus for screening or sifting or for separating solids from solids using gas currentsGeneral arrangement of plant, e.g. flow sheets
• B03C 1/30 - Combinations with other devices, not otherwise provided for

Abstract

wastewasteinertnon-inertnon-inert; and S30, establishing a general linear equation. The beneficial effects of the present invention are as follows: a construction waste mixture conforming to a classification standard can be identified quickly and accurately at a low cost, and construction waste having low classification and recycling value is excluded, thereby reducing the time cost and mechanical cost, and improving the treatment efficiency of the construction waste.

IPC Classes  ?

• G06Q 10/063 - Operations research, analysis or management

Abstract

222, and wherein the iron-based metal complex has undergone a pulsed laser treatment for increasing catalytic surface area, number of catalytic sites and/or catalytic efficiency of the iron-based metal complex when compared with untreated iron-based metal complex before the pulsed laser treatment.

IPC Classes  ?

• C08G 83/00 - Macromolecular compounds not provided for in groups
• C25B 1/30 - Peroxides
• C25B 1/50 - Processes

Abstract

Disclosed is an automated method for evaluating the ZP-binding capability of spermatozoa according to their morphological features in assisted reproduction using deep learning. Also provided is a method of predicting fertilization success in clinical assisted reproduction based on the ZP-binding capability of spermatozoa.

IPC Classes  ?

• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G06T 7/00 - Image analysis
• G06N 3/08 - Learning methods

Abstract

An ambient noise differential adjoint tomography system(l) is provided. The system(l) comprises seismic wave recording devices(101,102,103) and a processor) 100). The processor) 100) indicates three of the seismic wave recording devices(101,102,103) as a source(lOl), a first receiver) 102), and a second receiver) 103), and the source(lOl) and the first and second receivers (102, 103) are arranged as a linear array, and the first and second receivers(102,103) are positioned nearby each other. The processor) 100) receives seismic noise and obtain a noise interferometry, computing synthetic dispersive surface wave signals, generating a differential adjoint tomography based on observed dispersive surface wave from the noise interferometry. The processor) 100) estimates a shear wave velocity from the differential adjoint tomography, using the estimated tomography to estimate the characteristic of the region, and the processor) 100) provide a diagram with characteristic of the region through a display or printer.

IPC Classes  ?

• G01V 1/28 - Processing seismic data, e.g. for interpretation or for event detection
• G01V 1/30 - Analysis

Abstract

Provided is a reliable and convenient approach to achieve precise control of gene expression in the liver in vivo. The methods generally combine a doxycycline-inducible gene expression system with a Sleeping Beauty transposon vector and hydrodynamic injection, enabling efficient integration of a controllable gene expression system into the genome of hepatocytes. The doxycycline-inducible system generally allows for precise and reversible control of gene expression. In some forms, a combination of gene alterations and overexpression of Myc leads to the development of HCC in animals. The method can also use a vector that allows for the inducible expression of a tumor antigen. The method can also induce tumor antigen-specific T-cell immune responses, providing a potent tool for the development of targeted therapies for HCC.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• A61P 35/00 - Antineoplastic agents

Abstract

A system and devices provide for accurate localization of orthopedic implants based on magnetic tracking approach (MTA) technology and without radiation. The system includes at least one magnetic beacon that is joined to an orthopedic screw/implant fixed to a patient's spine. A detector in the form of a magnetic sensor array detects the magnetic field from the beacon and produces an electrical signal in response thereto. A computer using a multi-objective magnetic location algorithm tracks the spatial position and movement of the beacon based on the electrical signal, and hence tracks the patient's spine.

IPC Classes  ?

• A61B 5/06 - Devices, other than using radiation, for detecting or locating foreign bodies

Abstract

A hypoventilation physical model is provided. Particularly the physical model includes brainstem and cerebral organoids derived from pluripotent stem cells (PSCs) having a PHOX2B gene mutation. This mutation includes polyalanine repeat expansion mutations (PARMs), specifically 5-PARM, 7-PARM, and 13-PARM. These PARMs occur within a 20-alanine (20-Ala) polyalanine tract in exon 3 of the PHOX2B gene. The physical model provides a platform for studying impaired ventilatory responses and associated neuronal defects, offering a valuable tool for drug screening and the development of therapeutic strategies for hypoventilation syndromes.

IPC Classes  ?

• C12N 5/079 - Neural cells
• C12M 1/32 - Inoculator or sampler multiple field or continuous type
• C12N 9/22 - Ribonucleases

Abstract

An ultrafast wide-field quantum sensing device using a neuromorphic event-based vision sensor includes a laser generating a laser beam; a dichroic mirror directing the laser beam onto a diamond sample and passing the laser beam reflected from the diamond, and an event camera receiving from the dichroic mirror the beam reflected from the diamond. A source of microwave energy applied to the diamond. A pulse generator synchronizes the microwave source and the event camera to create CW-ODMR measurements, wherein trigger pulses from the pulse generator are applied to the camera and microwave source. The optically detected magnetic resonance (ODMR) resonance frequency is determined based on the CW-ODMR measurements.

IPC Classes  ?

• G01R 33/32 - Excitation or detection systems, e.g. using radiofrequency signals
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• G01N 22/00 - Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping

Abstract

It has been discovered that the presence of cholinergic T cells is important for an effective immune response to hepatocellular carcinoma (HCC). The results demonstrate a novel aspect of the regulation of cancer immunosurveillance by an immune cell-derived neurotransmitter and shed light on its role in supporting cells mounting anti-tumor responses. Disclosed are methods of treating HCC in a subject in need thereof. Generally, the methods involve treating the subject with a therapy effective to increase the level of acetylcholine in T cells. Also disclosed are method where the subject is treated with anti-PD-1 immunotherapy when the determined level of cholinergic T cells in the subject is high or refraining from treating the subject with anti-PD-1 immunotherapy when the determined level of cholinergic T cells in the subject is low.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 35/00 - Antineoplastic agents

Abstract

The subject invention pertains to photocleavable prodrugs that facilitate the controllable drug delivery to the target sites modulated by light irradiation, including a photocleavable boron-dipyrromethene-derived prodrug and a dye, which achieved both high prodrug loading capacity (˜99%) and efficient light-triggered prodrug activation. The incorporation of the dye not only stabilized the nanoparticles and contributed tumor targeting as usual. but also exhibited degradation after light irradiation and in-situ monitoring of nanoparticle dissociation by fluorescent imaging.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo

Abstract

A quantum-inspired parallel annealing method that enables full parallelism and improves solution quality, resulting in significant speed and energy improvement when implemented in analog memristor crossbars. Tasks are experimentally solved, including unweighted and weighted Max-Cut and traveling salesman problem using an integrated memristor chip. The method claimed herewith effective exploits the natural parallelism, analog conductance states and all-to-all connection provided by memristor technology, and therefore demonstrates significant improvements in time- and energy-efficiency compared to previous simulated annealing and Ising machine implemented on other technologies, having a large potential for solving complex optimization problems with greater efficiency.

IPC Classes  ?

• G06F 17/18 - Complex mathematical operations for evaluating statistical data
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or

Abstract

A mechanoionic current generator comprising: a working electrode including an activated carbon cloth; and a counter electrode including a raw carbon cloth and a hydrogel; wherein the hydrogel has a plurality of flexible and asymmetrically shaped structures; and the working electrode has a surface immersed in the hydrogel and provided with a plurality of oxygen-containing functional groups. The ionic current generation mechanism of the current generator is naturally compatible with living organisms and living hydrogels, as exemplified by a self-powered drug delivery patch for wound healing. The current generator provides excellent outputs of current and charge transfer which are advantageous for various biomedical applications.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• H02N 1/04 - Friction generators
• H02N 2/00 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction
• H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators

Abstract

A SDT computation system is provided. The SDT computation system includes a SDT module, an ACAM array, and a mapping module. The SDT module is for outputting a final probability and configured to provide a SDT structure with a root node and deeper inner nodes for calculating probability, in which the final probability of each leaf node of the SDT structure is a product of all of node probabilities along a path from the root node to each leaf node, and wherein a final output of the SDT module is from a leaf with the highest probability. The mapping module is configured to map the SDT structure into the ACAM array, such that each of the ACAM cells in the ACAM array has a threshold programmed to be a parameter for a node in a path leading towards the leaf node of the SDT structure.

IPC Classes  ?

• G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements
• G06N 7/02 - Computing arrangements based on specific mathematical models using fuzzy logic
• G11C 27/00 - Electric analogue stores, e.g. for storing instantaneous values

Abstract

The I-DID system is strengths-weaknesses based assessment and intervention for dyslexia, particularly for dyslexia in bilingual users. The system includes a database comprising a large-scale profile of a plurality of user performance sets across five domains: language and literacy, cognition, creativity, music, and social-emotional skills. A machine learning-based subgroup generator creates subgroups to provide individualized intervention for each of the subgroups, such that the users in the different subgroups receive different interventions. The interventions comprise training in one or more domain-general cognitive and music skills, or language-specific listening, speaking, reading, writing, or combinations thereof. The combined theory-and data-driven approach of the system integrates multiple layers of online multifaceted assessments and classifies strength-weakness profiles of bilingual users for self-managed, personalized game-based intervention. The system promotes affordability, efficiency, equality and sustainability of clinical diagnosis and treatment for bilingual users along with users growing up in a multilingual environment.

IPC Classes  ?

• G09B 19/06 - Foreign languages
• G09B 5/02 - Electrically-operated educational appliances with visual presentation of the material to be studied, e.g. using film strip
• G10L 15/22 - Procedures used during a speech recognition process, e.g. man-machine dialog

Abstract

GREM2 compositions and formulations thereof are described for use in treating or preventing one or more symptoms of a disease associated with loss of bone mineral density. Recombinant GREM2 have been shown to reduce bone resorption, reduce bone turnover markers, and increase bone strength. Methods of using the GREM2 compositions and formulations are also provided. Preferably, the pharmaceutical formulation containing GREM2 is administered via parenteral route to prevent or alleviate one or more symptoms of osteoporosis, osteopenia, bone fractures, and/or bone cancer.

IPC Classes  ?

• C07K 14/51 - Bone morphogenic factorOsteogeninOsteogenic factorBone-inducing factor
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 19/00 - Drugs for skeletal disorders
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
• C12N 15/12 - Genes encoding animal proteins

Abstract

The present invention provides a solution-processed metallic nanoparticle reflective electrode, which forms well-dispersed compactly packed structures during the stacking process. Featuring the self-packing ability of metallic nanoparticles and a higher space proportion, ligand-assisted metallic nanoparticles with a uniformdistribution of particle size and superior storage stability can formhigh-quality metallic nanoparticle filmin low-temperature sintering. Finally, attributing to the superior electrical and optical properties, and facile post-treatment of electrodes, a fully solution-processed OSCs with the ligand-assisted metallic nanoparticles electrodes achieve the record high efficiency of 14.69% for large-area devices (≥ 1 cm2).

IPC Classes  ?

• H10K 30/81 - Electrodes

Abstract

Described herein are methods for preparing chiral α-amino acids using chiral phosphoric acids as catalysts. The disclosed methods can use amino-malonic acids as substrates to generate chiral amino acids with a variety of side chains in high optional purity (such as an ee value of at least 70%) and with a high yield (i.e., a yield of at least 80%, such as in a range from about 80% to about 99%), via an asymmetric decarboxylation reaction. The decarboxylation reaction of the methods is catalyzed by chiral phosphoric acids that can achieve a selective protonation during decarboxylation, which is considered one of the most difficult processes in asymmetric catalysis.

IPC Classes  ?

• C07C 227/18 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
• B01J 31/02 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
• C07C 229/42 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• C07C 235/52 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
• C07C 247/12 - Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
• C07C 255/30 - Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
• C07C 255/58 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 317/48 - SulfonesSulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
• C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 209/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
• C07D 307/54 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 317/30 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 333/24 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• C07D 411/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
• C07D 493/04 - Ortho-condensed systems
• C07J 41/00 - Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Abstract

The present invention provides a method for scalable fabrication of ultra-flat polycrystalline diamond membranes, the method comprising: (1) performing chemical vapor deposition on a growth substrate having diamond seeds thereon to grow a polycrystalline diamond membrane, wherein an exposed surface of the polycrystalline diamond membrane is a grown surface having a first roughness; and a surface bonded to the growth substrate is a buried surface; (2) bonding the grown surface to a transfer substrate using an adhesive; and (3) removing the growth substrate to expose the buried surface of the polycrystalline diamond membrane, wherein the buried surface has a second roughness after exposure, and the second roughness is less than the first roughness.

IPC Classes  ?

• C30B 28/14 - Production of homogeneous polycrystalline material with defined structure directly from the gas state by chemical reaction of reactive gases
• C30B 29/04 - Diamond
• C30B 29/64 - Flat crystals, e.g. plates, strips or discs
• C30B 33/12 - Etching in gas atmosphere or plasma
• C30B 35/00 - Apparatus not otherwise provided for, specially adapted for the growth, production or after-treatment of single crystals or of a homogeneous polycrystalline material with defined structure

Abstract

Provided herein is a platform that supports the survival and phenotype maintenance of leukemia cells by co-culturing the cells with 3DON. The 3D osteogenic niche (3DON) mimics that in bone marrow to support AML cell survival in cultures before treatment with sample chemotherapy drug. The 3DON is comprised of osteogenically differentiated mesenchymal stromal cells (MSCs) microencapsulated in 3D microspheres made from extracellular matrix (ECM). Also provided is a method that increases the chemo-sensitivity of leukemia cells by co-culturing them with 3DON. The platform may be used for drug screening applications and the 3DON may be used as an adjuvant for chemotherapy.

IPC Classes  ?

• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Provided is a singlet oxygen-cleavable anti-VEGF prodrug. Provided is a composition comprising a photosensitizer and biocompatible polymer for the co-assembly of photoactivatable nanoparticles with the singlet oxygen-cleavable anti-VEGF prodrug. This red-light-activatable prodrug composition can be used in methods for the combined anti-angiogenesis and PDT treatment of wet AMD and other diseases, capable of light-controllable drug delivery to the CNV lesions and other disease sites via noninvasive intravenous administration.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/51 - Nanocapsules
• A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
• A61P 27/02 - Ophthalmic agents

Abstract

A transcorneal electrical stimulation (TES) apparatus for treating brain diseases is provided. The apparatus includes an eye-contacting interface with at least one active electrode, an inactive reference electrode, and a current source. Both the active and reference electrodes are electrically connected to the current source, facilitating transcorneal electrical stimulation for various applications.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

Ocular antimicrobial compositions and methods and method of use thereof are provided. The compositions incorporate photoactive heterojunction materials can be incorporated into a suitable carrier, alone or in combination with an enzyme capable of generating ROS upon contact with the eye for the treatment of ocular conditions. The method includes contacting the eye of a subject in need thereof, the subject has or has been diagnosed with microbial keratitis, with an effective amount of the disclosed composition. The method further includes contacting the composition in the subject's eye with near infrared radiation (NIR).

IPC Classes  ?

• A61K 38/44 - Oxidoreductases (1)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 38/06 - Tripeptides
• A61K 38/07 - Tetrapeptides
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61K 41/17 - Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• A61P 27/02 - Ophthalmic agents
• A61P 31/04 - Antibacterial agents

Abstract

A positioner comprising a nested pair of robots suitable for MRI-guided live-imaging, head-mounted bilateral stereotactic neurosurgery. Specifically, the positioner is suitable for locating a needle holder for tubular/needle-like instrument during neurosurgical operation. While maintaining a sufficient workspace (± 35°), the positioner remains lightweight (203 g) and compact ( Ø 81 mm × 97 mm height), enabling skull-mounted usage within most standard imaging head coils. The five-bar linkage architecture allows the reservation of exposure space around the incision port (burr hole on the skull) for operation/observation. The robot system operates in two stages: i) manual coarse adjustment within a large workspace performed interactively by the surgeon, followed by ii) automated fine adjustment within a localized motion range performed by soft fluid-driven actuators.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• A61B 17/06 - NeedlesHolders or packages for needles or suture materials

Abstract

Provided herein are insulin receptor (INSR) agonists compounds of Formula I-IV or compositions containing the compounds, the use of these compounds or compositions in the treatment of diabetes. The compounds and compositions can bind to the allosteric sites on INSR and activate INSR and downstream signaling pathways synergistically with insulin by phosphorylating INSR proteins.

IPC Classes  ?

• C07K 5/065 - Dipeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

An event-guided auto-exposure (EG-AE) device leverages the high dynamic range and low latency properties of a dynamic vision sensor to guide the exposure setting of an active pixel sensor. The method utilizes physical connections of images and events to estimate the irradiance variations, which are fed into the EG-AE device for calculating the exposure setting. The method shows outstanding performance in tackling highly challenging lighting conditions and benefits multiple downstream applications, including visual tag detection and feature matching.

IPC Classes  ?

• H04N 23/73 - Circuitry for compensating brightness variation in the scene by influencing the exposure time
• H04N 23/71 - Circuitry for evaluating the brightness variation
• H04N 23/72 - Combination of two or more compensation controls
• H04N 23/74 - Circuitry for compensating brightness variation in the scene by influencing the scene brightness using illuminating means
• H04N 25/47 - Image sensors with pixel address outputEvent-driven image sensorsSelection of pixels to be read out based on image data

Abstract

The present invention relates to an ultrasensitive rapid antigen detection kit for detecting N protein from SARS-CoV-2 virus in a sample, and methods for detecting N protein. The kit includes a sample collector, a collection and enrichment tube and a rapid antigen detection component with a test strip. The collection and enrichment tube contains a first part containing lyophilized ATPS reagents and a second part containing a lysis buffer. The sample is mixed with the lyophilized ATPS reagents and the lysis buffer to form a mixture. The enrichment is realized by concentrating the target analyte into one of the two phases formed by ATPS.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Compositions and methods for the reliable molecular monitoring of NPM1 mutations are disclosed. The methods enable pre-emptive therapy essential for understanding AML disease status, informing therapeutic options, monitoring therapeutic efficacy, and improving patient outcome. The methods simultaneously screen and quantify samples having the major NPM1 mutant subtypes. In some forms, methods for detecting and measuring a presence, absence, and/or level of mutation of the NPM1 gene in a sample include hybridizing labelled sequence probes to the NPM1 gene in a sample to form labelled probe-nucleic acid conjugates, amplifying the probe-nucleic acid conjugates, and detecting the labelled probe-nucleic acid conjugates by measuring the level of one or more labels attached to the probes. The methods optionally record the presence, absence and/or level of NPM1 mutations in the sample.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

A method for aquatic microplastic identification is provided. The method includes steps as follows: emitting a laser beam from a laser source, such that the laser beam passes through a liquid sample with MP samples in a sample channel and then a polarizer and is received by polarization camera; capturing a sample image of the MP samples by the polarization camera, wherein the sample image comprises interference patterns resulting from superposition of object and reference waves; and feeding the interference patterns into a morphology analyzing module for real-time tracking and analyzing by using a lightweight convolutional neural network (CNN) model, so as to classify the MP samples.

IPC Classes  ?

• G01N 21/21 - Polarisation-affecting properties
• G03H 1/00 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto
• G03H 1/04 - Processes or apparatus for producing holograms
• G06V 10/147 - Details of sensors, e.g. sensor lenses
• G06V 10/34 - Smoothing or thinning of the patternMorphological operationsSkeletonisation
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• H04N 23/55 - Optical parts specially adapted for electronic image sensorsMounting thereof