A solid-state ion-conducting structure comprises a plurality of grains formed of a first material composition and a second material composition different from the first material composition. The second material composition can wet boundaries of the grains and/or fill voids between adjacent grains. Each of the material compositions can have an ionic conductivity greater than or equal to 10−4 S/cm. The second material composition may be considered a volatile sintering aid. for example. having a melting point less than a temperature at which the first material composition is sintered. In some embodiments, the solid-state ion-conducting structure can be used as a solid-state electrolyte in a battery.
The present disclosure describes various aspects of devices, and methods of making and using the devices, for in vivo sensing of luminal concentration of a compound of interest within a gastrointestinal (GI) tract of a subject. An ingestible housing has an outer profile to pass through the subject's GI tract. A battery and a communication module are contained inside of the housing. A sensor is disposed on an outer surface of the housing. The sensor comprises one or more electrodes configured to contact luminal contacts of the subject's GI tract while the sensor is in motion traversing through the subject's GI tract. A plurality of electrical signals is controlled, and comprises attributes relating to a property of the compound of interest. A continuous output signal is received from the sensor, indicating an extent to which the compound of interest is present in the luminal contents.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
3.
THERMOCHEMICAL CONVERSION METHODS, AND REACTOR SYSTEMS FOR THERMOCHEMICAL CONVERSION
An organic polymer can be converted to one or more lower molecular weight products by subjecting to one or more heating cycles in a porous reactor. The reactant can be provided to an inlet end of the reactor, and the products can be provided from an outlet end of the reactor. A first reactor portion at the inlet end of the reactor can have a pore size or porosity greater than that of a second reactor portion at an outlet end of the reactor. In some embodiments, the different pore sizes or porosities of the reactor portions can modulate mass transport and/or heat transfer behavior of intermediates to select for particular products at the outlet end with high yield.
4.
THERMALLY RESPONSIVE PARTITIONS FOR DEVICES AND SYSTEMS AND METHODS OF USING SAME
A method and test system for detecting the presence of an analyte in a sample comprising a binding region and a detecting region, where the binding region contains a plurality of magnetic beads attached to a plurality of first capture molecules that bind to an analyte of interest in the sample, and a plurality of second capture molecules having a detectable label attached thereto, where the second capture molecules bind to the analyte of interest to form a complex, where the complexes are moved through at least one liquefied aliphatic partition via a magnetic field into the detecting region that having a detection composition allows for detection and, optionally, for signal quantification.
A61F 9/00 - Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
A reactant comprising one or more polymers can be subjected to multiple consecutive processing cycles. Each processing cycle can have a first period with heating applied and a second period immediately following the first period with no heating applied. A duration of each processing cycle can be less than or equal to 10 seconds, and a duration of each first period can be less than 1 second. The subjecting can be effective to convert at least some of the reactant into one or more products, for example, one or more constituent monomers or other volatile or gas-phase species. In some embodiments, a reactor can be provided between a heating source and the reactant, for example, to provide a spatio-temporal temperature profile for improved polymer processing.
C08J 11/12 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation by dry-heat treatment only
A system for imaging through an obscurant, includes a spatial light modulator (SLM) or a deformable mirror array (DMA) configured to modulate light, one or more sensors configured to capture an image, a processor, and a memory. The memory includes instructions stored thereon, which when executed by the processor cause the system to: incoherently illuminate a target by a light, the obscurant scatters the light creating an optical aberration; modulating the scattered light by the SLM or DMA; capture an image by the one or more sensors of the target as illuminated by the modulated light; generate a simulated image by a differential model; compare the captured image with the simulated image; estimate the target, the aberration, and a phase delay based on back-propagation of the comparison; and correct for the aberration based on at least one of the estimated target, the aberration, or the phase delay.
A non-contact system for the sensing of pH includes a hyperspectral imaging device configured to capture a hyperspectral image of a fluid, a flow cell configured to enable the capturing of a hyperspectral image of a fluid, a process, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the system to generate a hyperspectral image of the fluid in the flow cell, generate several spectral signals based on the hyperspectral image, provide the spectral signal as an input to a machine learning network, and predict by the machine learning network a pH of a fluid.
G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
9.
Rechargeable Divalent Metal Batteries Having Fast Interfacial Charge Transfer Kinetics
The present disclosure provides rechargeable divalent metal batteries comprising a multidentate compound. In particular, the presence of a multidentate compound in the electrolyte of the rechargeable divalent metal batteries significantly increases the interfacial charge transfer kinetics and/or suppresses undesired side reactions on both cathodes and metal anodes. It is believed that these effects are at least in part due to solvation sheath reorganization by the multidentate compound. Other aspects of the disclosure include methods for reducing a charge transfer overpotential and methods for increasing a charge transfer kinetics in rechargeable divalent metal batteries.
A solid-state device includes a substrate with a stack of constituent thin-film layers that define an arrangement of electrodes and intervening layers. The constituent layers can conform to or follow a non-planar surface of the substrate, thereby providing a 3-D non-planar geometry to the stack. Fabrication employs a common shadow mask moved between lateral positions offset from each other to sequentially form at least some of the layers in the stack, whereby layers with a similar function (e.g., anode, cathode, etc.) can be electrically connected together at respective edge regions. Wiring layers can be coupled to the edge regions for making electrical connection to the respective subset of layers, thereby simplifying the fabrication process. By appropriate selection and deposition of the constituent layers, the multi-layer device can be configured as an energy storage device, an electro-optic device, a sensing device, or any other solid-state device.
H01L 21/32 - Treatment of semiconductor bodies using processes or apparatus not provided for in groups to form insulating layers thereon, e.g. for masking or by using photolithographic techniques; After-treatment of these layers; Selection of materials for these layers using masks
C23C 14/04 - Coating on selected surface areas, e.g. using masks
C23C 16/04 - Coating on selected surface areas, e.g. using masks
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 21/3205 - Deposition of non-insulating-, e.g. conductive- or resistive-, layers, on insulating layers; After-treatment of these layers
H01L 31/0445 - PV modules or arrays of single PV cells including thin film solar cells, e.g. single thin film a-Si, CIS or CdTe solar cells
H01L 33/08 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a plurality of light emitting regions, e.g. laterally discontinuous light emitting layer or photoluminescent region integrated within the semiconductor body
H01L 33/38 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the electrodes with a particular shape
The present disclosure provides aqueous electrolytes with a lower salt concentration and wider electrochemical stability window compared to water-in-salt electrolytes. The aqueous electrolyte composition of the disclosure comprises an anti-solvent, which reduces the H2O activity and the amount of H2O in the Li-ion solvation sheath. In one particular embodiment of the disclosure provides a nonflammable aqueous electrolyte composition for a lithium-ion battery, wherein the aqueous electrolyte composition comprises: an electrolyte salt comprising a lithium salt; water; and an organic component that is miscible with water. In some embodiments, the electrochemical stability window of the aqueous electrolyte composition is greater than 3.0 V and a molality of an electrolyte salt in said aqueous electrolyte composition is about 5 m or less.
A first structure of a microfluidic system is fabricated via a first additive manufacturing process. The first structure has at least one first fluidic port and at least one first conduit. Each first conduit connects to one of the at least one first fluidic port. A second structure of the microfluidic system is fabricated on the first structure via a second additive manufacturing process. The second structure has at least one second conduit. The second structure is fabricated such that the at least one second conduit is sealed to the at least one first fluidic port and such that the at least one first conduit is in fluid communication with the at least one second conduit. The second additive manufacturing process employs ex situ direct laser writing, while the first additive manufacturing process employs an additive manufacturing modality different from the second additive manufacturing process.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
A catalytic structure has a substrate and a plurality of high-entropy alloy (HEA) nanoparticles. At least a surface layer of the substrate is formed of a metal oxide. The HEA nanoparticles can be formed on the surface layer. Each HEA nanoparticle can comprise a homogeneous mixture of at least four different elements forming a single-phase solid-solution alloy. The catalytic structures can be used to catalyze a chemical reaction, such as an ammonia oxidation reaction, an ammonia synthesis reaction, or an ammonia decomposition reaction.
B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
This present disclosure is directed to composite cathode compositions, liquid electrolyte compositions, and rechargeable batteries comprising said novel cathode compositions and electrolyte compositions.
15.
High-entropy alloy (HEA) catalysts, methods of forming HEA catalysts, and methods of using HEA catalysts
A catalytic structure has a plurality of high-entropy alloy (HEA) nanoparticles. Each HEA nanoparticle is composed of a homogeneous mixture of elements of cobalt (Co), molybdenum (Mo), and at least two transition metal elements. For example, in some embodiments, each HEA nanoparticle is a quinary mixture of Co, Mo, iron (Fe), nickel (Ni), and copper (Cu). The homogeneous mixture in each HEA nanoparticle forms a single solid-solution phase. The catalytic structure is used to catalyze a chemical reaction, for example, ammonia decomposition or ammonia synthesis. Methods for forming the catalytic structure are also disclosed.
The present disclosure provides a class of chiral metal nanomaterials having controllable imbalanced chiral facets on their surfaces and preparation method thereof. Also provided is a method of preparing a chiral hybrid nanomaterial comprising chiral metal core with imbalanced chiral facets and semiconductor shell. Advantageously, the present chiral metal nanomaterials may be useful in the design and fabrication of other functional materials and devices with tailored chirality.
B22F 9/24 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
B82Y 40/00 - Manufacture or treatment of nanostructures
17.
EMBRYONIC CELL CULTURES AND METHODS OF USING THE SAME
The invention provides a composition comprising an extroembryonic endodermal (XEN) cell and/or an embryonic fibroblast (EP) cell. The invention also provides a method of establishing a XEN cell line or a primary embryonic fibroblast (EF) cell line in vitro, the method comprising culturing a zygote or parthenote from a manual for a time sufficient to produce one or more blastocysts; and culturing the one or more blastocysts on feeder cells in culture medium for a time sufficient to produce one or a plurality of XEN cells and/or one or a plurality of EF cells.
The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant or otherwise treating a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant. The vector may be modified to include an siRNA effective against a bacterial plant pathogen. Alternatively, the wild type vector may be introduced into the plant to inhibit or control a bacterial infection in the plant by way of non-specific siRNA created by the RNA silencing or transitive silencing mechanism of the plant. Alternatively, the vector may be modified to include an insert that increases a silencing mechanism of the plant, for example an insert that is a complement to a plant virus.
Aspects of the present disclosure describe techniques that involve an active stabilization of coherent controllers using nearby qubits. In an aspect, a quantum information processing (QIP) system for stabilizing phase damping in qubits is described that provides a first and a second qubit ion, measuring magnetic field fluctuations using the second qubit ion, and generates one or more magnetic fields based on the measured magnetic field fluctuations, the one or more magnetic fields being applied near the first qubit ion to cancel the magnetic field fluctuations to stabilize the phase damping of the first qubit ion. Another such QIP system performs provides a first and a second qubit ion, locks a local oscillator to a frequency reference associated with the second qubit ion, and tracks, using the local oscillator, a frequency of the first qubit ion based on the frequency reference. Methods associated with these QIP systems are also described.
Degraded electrode material from a used battery can be recycled by subjecting to a thermal shock. The degraded electrode material can have impurities resulting from charge/discharge cycling of the battery. The thermal shock can have a temperature of at least 1000 K for a time period of 10 seconds or less, for example, less than or equal to 1 second. The thermal shock can also include a heating rate of at least 103 K/second preceding the time period and a cooling rate of at least 103 K/second following the time period. The subjecting to the thermal shock regenerate the electrode material, for example, by removing impurities from the electrode material and/or replenishing metal ions within the electrode material.
Government of the United States of America, as Represented by the Secretary of Commerce (USA)
Inventor
Burenkov, Ivan A.
Polyakov, Sergey V.
Abstract
A quantum EIT-based optical switch includes a first waveguide, linear or nonlinear, a separate nonlinear waveguide evanescently coupled to the first waveguide, and a pump coupled to the nonlinear waveguide. A quantum STIRAP-based optical transduction device, which includes an auxiliary, intermediate spectral state for the quantum signal that aids efficient transduction of the quantum signal from the input spectral state to the output spectral state in a single device.
The approach disclosed herein is a process for non-equilibrium chemical and materials processing using the combination of non-equilibrium plasma, non-equilibrium multi-functional catalysis, a precisely programed heating and quenching (PHQ), and supersonic reaction quenching to dynamically change the chemical equilibrium and increase the yield and selectivity of the products. An important feature of the disclosed approach is to realize an efficient and high selectivity synthesis method of chemicals and materials by using non-chemical equilibrium, non-equilibrium catalysts, and non-equilibrium of excited states via active control of molecule excitation by low temperature hybrid plasma, dynamics of chemical reactions by programed heating and supersonic quenching, and the design of non-equilibrium catalysts by thermal shocks and plasma coupling to enable distributed and electrified chemical synthesis of hydrogen, ammonia, valued carbon and other chemical products at atmospheric conditions. As such, the disclosed approach will enable distributed, electrified, low-carbon, and non-equilibrium chemical and material synthesis using renewable electricity, fossil fuels, biomass, and other abundant or waste resources.
The present disclosure relates to a viral vector having an exogenous RNA segment with a hairpin-like structure, for example having two or more base-paired regions separated by one or more non-base-paired regions. The exogenous RNA segment may have a secondary structure, minimum free energy, average positional entropy or other attributes within specified ranges, or with values similar to one or more hairpin-like structures of a reference wild type virus. In some examples, the viral vector is a live attenuated vaccine. In some examples, the viral vectors downregulates a susceptibility gene in a host plant.
A system for the sensing of pathogens includes a sensor, a processor, and a memory. The sensor is configured to generate a signal indicating a conductivity of the sensor. The memory includes instructions stored thereon, which, when executed by the processor, cause the system to receive the signal from the sensor, determine a change in a conductivity of the sensor based on the signal, and determine the presence or the absence of a pathogen based on the determined change in conductivity.
The present disclosure is directed to electrolyte membrane compositions, electrolyte membranes, batteries utilizing said electrolyte membranes, and methods of assembling said batteries. The electrolyte membranes disclosed herein provide membranes and electrolytes for sustainable and more robust batteries.
Amorphous nanoparticle compositions comprising a photosensitizer along with methods of making and using the same are provided. In particular, the amorphous nanoparticle compositions are generated and used in carrier-free, solubilizing agent-free applications to improve the photophysical and photochemical stability of clinically used photosensitizers, particularly verteporfin. The amorphous nanoparticle compositions may be used in fluorescence-guided surgery, photodynamic therapy of cancer and non-cancer diseases, fluorescence diagnosis of cancer and non-cancer diseases, blood-brain barrier opening, drug delivery to the brain, and/or in various other types of treatments and implementations.
The disclosure describes aspects of using multiple species in trapped-ion nodes for quantum networking. In an aspect, a quantum networking node is described that includes multiple memory qubits, each memory qubit being based on a 171Yb+ atomic ion, and one or more communication qubits, each communication qubit being based on a 138Ba+ atomic ion. The memory and communication qubits are part of a lattice in an atomic ion trap. In another aspect, a quantum computing system having a modular optical architecture is described that includes multiple quantum networking nodes, each quantum networking node including multiple memory qubits (e.g., based on a 171Yb+ atomic ion) and one or more communication qubits (e.g., based on a 138Ba+ atomic ion). The memory and communication qubits are part of a lattice in an atomic ion trap. The system further includes a photonic entangler coupled to each of the multiple quantum networking nodes.
Hydrogels are networks of polymer chains that are swollen in water. These gels can protect vulnerable objects (e.g., an egg or a fruit) if wrapped there around. Gels are constructed by either physical cross-linking (e.g., gelatin) or chemical cross-linking (e.g., acrylamide). The addition of starch granules to the above gels greatly enhances their protective abilities. When a load strikes a gelatin gel containing 20% starch, the peak impact force is reduced by 25% when compared to a bare gel without the starch. Correspondingly, the coefficient of restitution (COR) is also lowered by the presence of starch (e.g., a ball bounces less on a starch-bearing gel). The impact-absorbing effects of starch granules are correlated to their ability to shear-thicken water. When starch granules are gelatinized by heat, they no longer give rise to shear-thickening, and in turn, their protective ability in a gel is also eliminated.
G01N 3/303 - Investigating strength properties of solid materials by application of mechanical stress by applying a single impulsive force generated only by free-falling weight
C08L 51/10 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to inorganic materials
C08L 89/00 - Compositions of proteins; Compositions of derivatives thereof
G01N 3/06 - Special adaptations of indicating or recording means
This present disclosure is directed to functionalized single-walled carbon nanotubes, quantum emitter compositions comprising functionalized single-walled carbon nanotubes, and methods of making the same. The nanotubes and emitters disclosed herein provide higher degrees of selectivity of emission properties.
The microstructure of metallic and/or ceramic layers is controlled based on heating/cooling parameters of the fabrication process. The heating/cooling parameters can be selected to generate materials completely in the glass phase, having a hybrid construction (e.g., glass/crystalline) with different lattice microstructures, or having a polycrystalline microstructure with aligned crystal grains. Such materials with controlled microstructures can be used as solid-state electrolytes (SSEs), as cathodes in solid-state batteries, or as structural materials. When employed as SSEs, the glass phase portions of the fabricated materials can function as an interphase layer that blocks ion penetration and/or dendrite formation, while still retaining good ionic conductivity.
The present disclosure is directed to high entropy electrolyte compositions, batteries utilizing said electrolyte compositions, and methods of assembling and using said batteries. The fast ion-exchanging networks formed by the electrolyte compositions disclosed herein allow for operating conditions over a wide temperature range, allowing for efficient use at both high and low temperatures.
Ingestible capsule devices and methods of making these devices are presented. The device and method provide a capsule with embedded actuator for triggerable delivery of drug loaded structures, a freestanding region responsive bilayer (FRRB) comprising a rigid polyethylene glycol (PEG) layer under a flexible pH-responsive layer of methacrylic acid copolymers which protects capsule content until arrival in their target environment of the intestines. The actuator may be fabricated with a flexible cantilever to store mechanical energy and deploy when released using a heater and meltable polymer. The FRRB may be fabricated to form a multitude of shapes that provide functional packaging mechanisms for an underlying ingestible capsule with one or more features, such as openings or seams.
The present invention relates to aramid-derived carbon molecular sieve membranes, the preparation of said membranes, and uses thereof, including the separation of gases in a mixture. The aramid-derived carbon molecular sieve membranes of the present invention show excellent gas selectivity properties, and are able to be selective towards separating gases, such as H2, from a mixture of gases.
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
A solution blow spin device includes a syringe pump assembly, an airbrush adapter, and a handle base. The syringe pump assembly, airbrush adapter, and handle base are reversibly coupled to one another and configured to work in tandem to address wound dressing using a polymer solution and autologous skin cell suspension co-spray. The airbrush adapter includes multiple nozzles for deposition of multiple solutions sequentially or simultaneously in order to improve would dressing efficacy. The syringe pump assembly includes multiple syringes holding the multiple solutions, and the syringes can be emptied by individually addressable lead screws configured to translate blocks to depress syringe plungers when the lead screws are rotated via corresponding actuators.
Systems and methods for specialized data acquisition in capillary electrophoresis electrospray ionization mass spectrometry (MS) that includes (a) mass-to-charge (m/z) vs. migration time (MT) correlation, (b) ion mobility (IM) vs. MT correlation, and (c) m/z vs. IM vs. MT correlation to advance molecular analysis via data-dependent, data-independent, and targeted analysis methods executed on mass spectrometers using diverse types of mass analyzers, including but not limited to orbitrap, time-of-flight, and ion mobility time-of-flight mass analyzers. Electrophoresis-correlative (Eco) MS enhances the detection, identification, and quantification of molecules, as is demonstrated here for complex proteome samples.
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
G01N 27/623 - Ion mobility spectrometry combined with mass spectrometry
G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
H01J 49/06 - Electron- or ion-optical arrangements
A microsampling system includes a housing, a capillary fixed within a sealed internal environment defined by the housing, a robotic translation mechanism configured to support a sample holder and move the sample holder relative to the capillary in a plurality of directions, and a first port for connecting the sealed internal environment to a fluid source. A plurality of second ports may connect the sealed internal environment to a computing device, a voltage source, and/or a mass spectrometer ESI interface. A method of microsampling includes moving a sample holder within a sealed internal environment to operably position a capillary relative to a sample volume, pressurizing the sealed internal environment to inject a sample volume into the capillary, moving the sample holder to operably position the capillary relative to a BGE coupled to a voltage source, and applying electrical energy to separate the first sample volume via capillary electrophoresis.
POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION (Republic of Korea)
Inventor
Scarcelli, Giuliano
Kim, Yoon-Ho
Kim, Jin-Hun
Abstract
A system for noise-resistant quantum communication using hyperentanglement includes a quantum system that includes a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to access a signal of a quantum system that includes a plurality of qubits and obtain hyperentanglement of the plurality of qubits via an entanglement source. The hyperentanglement of the plurality of qubits is in at least two dimensions, including a first dimension and a second dimension. The instructions, when executed, further cause the quantum system to transmit the hyperentangled plurality of qubits via a communication channel; perform a communication of the signal with the first dimension of the at least two dimensions; and filter results of the communicated signal based on the second dimension of the at least two dimensions.
The present disclosure provides a one-pot chemoenzymatic method for site-specific modification and conjugation of antibodies at their Fc glycan site to produce structurally well-defined antibody conjugates carrying defined drugs and other entities. The method is enabled by the discovery that certain endoglycosidases have the ability to both deglycosylate an antibody and to recognize selectively modified small disaccharide oxazolines for transglycosylation on antibodies without hydrolysis of the resulting products.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 1/12 - General processes for the preparation of peptides by hydrolysis
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided. The described proteins can be used as a protein therapy, a gene therapy, or an implanted cell therapy.
C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)
C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
C12N 9/40 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase
40.
CYTIDINE DEAMINASES AND METHODS OF GENOME EDITING USING THE SAME
The present disclosure relates to compositions and methods that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within a plant genome. The disclosure provides base editing fusion polypeptides of a DNA binding domain, e.g., Cas9, and a cytidine deaminase domain. The base editors perform equally well or outperform existing technologies in C-to-T base editing efficiency while maintaining low frequency of introducing C-to-A and C-to-G byproducts.
Electroadhesion, adhesion induced by an electric field, occurs between non-sticky cationic and anionic hydrogels. When gel and tissue are placed under an electric field, the pair strongly adhere, and the adhesion persists indefinitely thereafter. Applying a direct current (DC) field with reversed polarity elimi-nates the adhesion. The use of electroadhesion can seal cuts or tears in tissues or model anionic gels. In an example, electroadhesion works with the aorta, cornea, lung, and cartilage. In another example, electroadhered gel-patches provide a robust seal over openings in bovine aorta, and a gel sleeve is able to rejoin pieces of a severed gel tube.
A full-field microscopy method for detection of Brillouin-scattered light includes illuminating a two-dimensional plane in a sample with interrogating light having a first wavelength. Light emitted from the two-dimensional plane can be collected. The emitted light comprises Brillouin-scattered light resulting from interaction of the interrogating light with the sample. The Brillouin-scattered light can have a second wavelength shifted from the first wavelength. The collected light can be passed through a spectrally-selective assembly comprising a gas or vapor illuminated by pumping light. After the spectrally-selective assembly, the Brillouin-scattered light from multiple points in the two-dimensional plane in the sample can be simultaneously detected by an electro-optical sensor. In some embodiments, the spectrally-selective assembly can be altered by changing a wavelength or polarization of the pumping light to allow acquisition of a Brillouin spectrum.
G01N 21/63 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
A method of producing a carbon nanotube may include heating a convergent flow nozzle and a flow chamber of a carbon nanotube reactor, flowing a vaporized reactant stream through the nozzle and collecting a carbon nanotube product from an outlet of a heated flow chamber disposed downstream of the heated convergent flow nozzle. The vaporized reactant stream may include a carbon nanotube nucleation carbon source, a carbon nanotube growth carbon source, and a carbon nanotube catalyst precursor. The nozzle may have a nozzle contraction ratio of from 3:1 to 300:1.
Aspects of the present disclosure describe techniques for controlling coherent crosstalk errors that occur in multi-channel acousto-optic modulators (AOMs) by applying cancellation tones to reduce or eliminate the crosstalk errors. For example, methods and systems are described that include calculating initial radio frequency (RF) tones to be applied to multiple channels of the AOM; calculating, in response to an application of the initial RF tones, compensation RF tones to be added to the initial RF tones to at least partially correct for undesired crosstalk effects; and in response to the application of the initial RF tones and the compensation RF tones, calculating subsequent compensation RF tones to be added to the initial RF tones until the crosstalk effect in each of the multiple channels is below a threshold level.
The present disclosure provides antibodies, and fragments thereof, conjugated to an oligonucleotide, wherein the oligonucleotide is not hybridized to a DNA dendrimer, compositions comprising the same, and uses thereof in methods of detection, methods of cell isolation, methods of depletion, methods of diagnosis, and methods of treatment.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/42 - Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
The present disclosure provides an accelerated AD model system for use in the diagnosis and prognosis of Alzheimer's disease (AD). The AD accelerated model system may also be used in screening assays for identifying therapeutic agents that correct, or alleviate, one or more of the cell culture phenotypes associated with the development of AD. Such phenotypes include, for example, increased tau phosphorylation, amyloid plaque accumulation, elevated levels of Aβ42 to Aβ40 ratio, increased cell death and cell cycle re-entry. The methods and compositions provided herein are based on the discovery that exogenously expressed progerin in neural progenitor cells leads to a robust and accelerated AD phenotype in said cells as they differentiate and that the modified and differentiated cells surprisingly produce factors which generate an aged environment (“aging factors”) for all the cells in their vicinity.
A carbon material can comprise a porous scaffold of carbon fibrils and particles of carbon black attached to the carbon fibrils. The carbon material can be provided in an atmosphere of a gas comprising one or more organic compounds, for example, methane. The carbon material and the gas can be subjected to a temperature (e.g., 1700 K) that causes the organic compound(s) to undergo pyrolysis to form carbon and hydrogen. For example, the carbon material can be used as a Joule heating element to heat the material and the gas to the pyrolysis temperature. At least some of the formed carbon can be deposited on or within the carbon material. As a result, the carbon fibrils in the material can merge to form a carbonized matrix, and the carbon black particles can become embedded within the carbonized matrix.
D01F 9/22 - Carbon filaments; Apparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyacrylonitriles
Government of the United States of America, as Represented by the Secretary of Commerce (USA)
Inventor
Seif Tabrizi, Seyed Alireza
Hafezi, Mohammad
Liu, Yi-Kai
Abstract
A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix.
A system for discovery of polymer composites can include one or more robotic systems and a machine learning system. The robotic system(s) can fabricate polymer composites, each comprising a mixture of at least two natural materials. The machine learning system can include a screening module, an input/output module, a data augmentation module, a training module, and a prediction module. The screening module can select a reduced design space for polymer composite mixture recipes. The input/output module can instruct the robotic system(s) to fabricate polymer composites and receive measurements of physical characteristics of the fabricated polymer composites to form a data set. The data augmentation module can augment the data set with virtual data points. The training module can train an artificial neural network (ANN) based on the augmented data set. The prediction module can predict a mixture recipe or physical characteristics for a desired polymer composite using the trained ANN.
Government of the United States of America, as Represented by the Secretary of Commerce (USA)
University of Massachusetts (USA)
Inventor
Lu, Xiyuan
Srinivasan, Kartik
Mcclung, Andrew
Abstract
A system for injection locking, including a light source configured to pump a first color light and a device configured to enable injection locking. The device includes a waveguide configured to couple to the light source and a microring resonator coupled to the light source via the waveguide. The microring resonator is a photonic crystal ring configured to enable injection locking. The microring resonator is configured to operate at a bandgap closing point, where reflection at a single frequency occurs.
H01S 3/108 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity using non-linear optical devices, e.g. exhibiting Brillouin or Raman scattering
H01S 3/06 - Construction or shape of active medium
H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
51.
Plant Vectors, Compositions and Uses Relating Thereto
The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of systemic and phloem-limited movement and replication within the host plant.
Fibers and an anionic polymer can be combined together in solution to form a slurry. Each fiber can comprise cellulose, and the anionic polymer can have one or more free anion groups. Metal ions and a foaming agent can be added to the slurry. The slurry can then be dried to form a foam, in which the metal ions are bonded between the anion groups of the anionic polymer. In some examples, the foam can be used as a thermally-insulating structure, for example, having a thermal conductivity less than or equal to 0.04 W/(m∙K). Alternatively, the foam can be used as a substrate for plant growth.
A system for detecting a gastrointestinal disorder includes a first sensor configured to generate a first signal indicative of a sensing of a first concentration of a biomarker in a flatus, a second sensor configured to generate a second signal indicative of a sensing of a second concentration of the biomarker in the flatus, a filter disposed on the second sensor, a processor, and a memory. The filter is configured to selectively remove the biomarker from the flatus prior to sensing by the second sensor. The memory includes instructions stored thereon, which when executed by the processor, cause the system to compare the first signal to the second signal to determine a concentration of the biomarker and provide an indication of the concentration of the biomarker, based on the comparison.
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
54.
DELIGNIFIED WOOD MATERIALS, AND METHODS FOR FABRICATING AND USE THEREOF
A delignified wood material is formed by removing substantially all of the lignin from natural wood. The resulting delignified wood retains cellulose-based lumina of the natural wood, with nanofibers of the cellulose microfibrils being substantially aligned along a common direction. The unique microstructure and composition of the delignified wood can provide advantageous thermal insulation and mechanical properties, among other advantages described herein. The thermal and mechanical properties of the delignified wood material can be tailored by pressing or densifying the delignified wood, with increased densification yielding improved strength and thermal conductivity. The chemical composition of the delignified wood also offers unique optical properties that enable passive cooling under solar illumination.
Provided are compositions and methods used for combating ticks and transmission of tick-borne pathogens to tick hosts. The compositions include tick mouthpart protein antigens. The method of using the compositions results in decreased tick persistence time, decreased tick feeding, and decreased tick-borne pathogen transmission from tick to the host.
C07K 14/435 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
56.
METHODS AND PLATFORMS FOR PROMOTING ANTIGEN-SPECIFIC TOLERANCE IN THE TREATMENT OF TYPE 1 DIABETES AND GRAFT REJECTION AND COMPOSITIONS RELATING THERETO
The present disclosure is directed to systems, compositions and methods for promoting immune tolerance to an antigen in a subject. Systems and methods provide for introducing directly into at least one lymph node(s) of the subject a therapeutically effective amount of a composition comprising an antigen associated with an autoimmune disease or disorder, in combination with a carrier comprising an immune modulatory agent such that an immune response to said antigen is inhibited or suppressed in the subject. The present disclosure is also directed to systems, compositions and methods for the treatment and/or prevention of autoimmune diseases and conditions, and in particular type 1 diabetes and graft rejection.
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 31/436 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
57.
3D Printed Scaffold Structures and Methods of Fabrication
An implantable scaffold device comprises a non-biodegradable backbone and a biodegradable dermal compartment comprising live cells. Method of fabricating implantable devices via 3D printing using a synthetic ink formulation coprinted with a biodegradable bioink.
A61L 27/54 - Biologically active materials, e.g. therapeutic substances
A61L 27/58 - Materials at least partially resorbable by the body
B29C 64/112 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
B29K 105/00 - Condition, form or state of moulded material
A piece of natural wood can be immersed in a first solution at a first temperature less than 100° C. and then immersed in a second solution at a second temperature greater than 100° C. so as to form a piece of partially-delignified wood. In some embodiments, the first and second solutions can be the same solution, and the immersion at the second temperature can be heating the solution from the first temperature to the second temperature. The immersion in the first and second solutions can be effective to remove 45-90% of lignin from the piece of natural wood and to destroy a structure of the ray cells in the piece of natural wood while retaining cell walls of the other cells. The partially-delignified wood can then be dried. After drying, the partially-delignified wood can be clastic along its tangential direction but inelastic along its radial and longitudinal directions.
Cancer immunotherapy deploys the host's immune system to recognize and attack cancerous tumors. However, the efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). In-situ cryo-immune engineering (ICIE) strategy turns the TME from immunologically “cold” into “hot”. In particular, after the ICIE treatment, the ratio of the CD8+ cytotoxic T cells to the immunosuppressive regulatory T cells is increased in primary tumors and distant tumors without freezing. The ICIE treatment causes “frostbite” of tumor with cold-responsive nanoparticles that target cancer cells. This rapidly releases both anticancer drug(s) and PD-L1 silencing siRNA into the cytosol. This ICIE treatment leads to potent immunogenic cell death, which promotes maturation of dendritic cells and activation of CD8+ cytotoxic T cells and memory T cells. Collectively, ICIE enables an efficient and durable way to leverage the immune system for combating cancer and its metastasis.
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61K 31/4745 - Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 38/17 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans
The present disclosure provides sensors, devices, systems and methods for detecting an analyte in a sample using electrochemical readouts. The sensors are electroassembled with abiological recognition element and are capable of specifically binding to analytes within a sample.
G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
61.
MULTIFUNCTIONAL ELECTROLYTE FOR PRIMARY CFX/LI BATTERIES
This present disclosure is directed to a multifunctional electrolyte composition for primary CFx/Li batteries, the composition and preparation of said batteries, and uses thereof, including low and high temperature usages. The design of the electrolyte composition allows for excellent discharge properties and robust use, even at temperatures as low as -70 °C.
Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are peptide complexes comprising three peptides, wherein each of the three peptides comprises a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; SARS-CoV-2 antigen; and a trimerization domain. Disclosed are compositions comprising any of the disclosed peptides or peptide complexes. Disclosed are methods for eliciting a protective immune response against SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein. Disclosed are methods of treating a subject exposed to SARS-CoV-2 or at risk of being exposed to SARS-CoV-2 comprising administering to a subject an effective amount of one or more of the compositions disclosed herein.
The present invention is directed to solid state electrolytes that comprise a coating layer. The present invention is also directed to methods of making the solid state electrolyte materials and methods of using the solid state electrolyte materials in batteries and other electrochemical technologies.
The disclosure describes an adaptive and optimal imaging of individual quantum emitters within a lattice or optical field of view for quantum computing. Advanced image processing techniques are described to identify individual optically active quantum bits (qubits) with an imager. Images of individual and optically-resolved quantum emitters fluorescing as a lattice are decomposed and recognized based on fluorescence. Expected spatial distributions of the quantum emitters guides the processing, which uses adaptive fitting of peak distribution functions to determine the number of quantum emitters in real time. These techniques can be used for the loading process, where atoms or ions enter the trap one-by-one, for the identification of solid-state emitters, and for internal state-detection of the quantum emitters, where each emitter can be fluorescent or dark depending on its internal state. This latter application is relevant to efficient and fast detection of optically active qubits in quantum simulations and quantum computing.
A formation of multielement nanoparticles is disclosed that includes at least three elements. Each of the at least three elements is uniformly distributed within the multielement nanoparticles forming nanoparticles having a homogeneous mixing structure. At least five elements may form a high-entropy nanoparticle structure. A method for manufacturing a formation of multielement nanoparticles includes providing a precursor material composed of the at least three component elements in multielement nanoparticles; heating the precursor material to a temperature and a time; and quenching the precursor to a temperature at a cooling rate to result in a formation of multielement nanoparticles containing at least three elements and the heating and the quenching representing a multielement nanoparticle thermal shock formation process. A corresponding system for manufacturing the formation of multielement nanoparticles and a method of using the multielement nanoparticles are also disclosed.
C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
B22F 9/24 - Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y 40/00 - Manufacture or treatment of nanostructures
C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
C22F 1/14 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of noble metals or alloys based thereon
66.
NUCLEAR REACTOR CORE WITH ROTATING FUEL MODULES AND RELATED SYSTEMS
Nuclear reactor cores and related systems are described herein. An example nuclear reactor core includes a plurality of fuel modules, where each of the plurality of fuel modules includes nuclear fuel; at least one fuel-module actuator mechanically coupled to at least one of the plurality of fuel modules, where the at least one fuel-module actuator is configured to rotate the at least one of the plurality of fuel modules; and at least one neutron source configured to emit neutrons and trigger a fission chain reaction in the at least one of the plurality of fuel modules.
Sparse nanophotonic arrays (NPAs) and holographic displays comprise a rectangular footprint including an active pixel area, wherein the active pixel area includes a plurality of light-emitting elements arranged in a starburst shape, and wherein a total number of the plurality of light-emitting elements in the active pixel area is equal to a predetermined fraction of a total resolution of a dense nanophotonic array having the rectangular footprint.
H03K 19/195 - Logic circuits, i.e. having at least two inputs acting on one output; Inverting circuits using specified components using superconductive devices
H03K 19/20 - Logic circuits, i.e. having at least two inputs acting on one output; Inverting circuits characterised by logic function, e.g. AND, OR, NOR, NOT circuits
69.
ATMOSPHERIC WATER HARVESTING COMPOSITE FOAMS, AND SYSTEMS AND METHODS FOR FABRICATION AND USE THEREOF
A system can employ an atmospheric water harvesting (AWH) composite. The AWH composite can include a foam and a plurality of deliquescent particles. The foam can include an organic polymer. The foam can have pore size of at least 1 μm. The deliquescent particles can be disposed on internal surfaces of the foam. The deliquescent particles can be formed of one or more hygroscopic materials. In operation, the AWH composite can be provided in an atmosphere having a relative humidity, such that water in the atmosphere is captured by the AWH composite. The captured water can be released by heating the AWH composite.
An engineered structure can be formed from multiple plant material pieces joined together without the use of an additional adhesive. In some examples, instead of an adhesive, a filler can be provided to enhance the surface chemistry of the constituent plant-material pieces, for example, by providing increased points for formation of hydrogen bonds, as well as providing a bridging effect by filling gaps within and/or between the constituent plant-material pieces. Alternatively, in some examples, lignin within the constituent plant-material pieces can be used as a bonding agent to couple together adjacent pieces. At least some of the pieces forming the engineered structure can be densified, lignin-compromised plant materials.
C08L 97/02 - Lignocellulosic material, e.g. wood, straw or bagasse
B27N 3/06 - Making particle boards or fibreboards, with preformed covering layers, the particles or fibres being compressed with the layers to a board in one single pressing operation
Provided are modified bacteria and methods of using the modified bacteria for prophylaxis or treatment of bacterial infections. The modified bacteria contain one or more genomic modifications such that the genomes of the bacteria are altered to encode and produce a holin protein and to encode and produce a lysozyme. The modified bacteria are illustrated using a type of Salmonella enterica (SE) in the form of autolytic SE serovar Typhimurium (S. typhimurium).
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, ARMY RESEARCH LABORATORY (USA)
Inventor
Saha, Uday
Waks, Edo
Siverns, James D.
Hannegan, John
Prabhu, Mihika
Englund, Dirk
Quraishi, Qudsia
Abstract
A system includes a quantum source and an optical device coupled to the quantum source. The quantum source is configured to emit an entangled photon. The optical device is configured to route the entangled photon to one or more outputs. In some aspects, the optical device can include a photonic integrated circuit (PIC). Advantageously the system can provide a routing scheme to route (e.g., passively, actively, dynamically, or a combination thereof) entangled photons from one or more quantum sources (e.g., trapped ion, single-photon source, quantum emitter, etc.) between different nodes, a quantum frequency conversion scheme to match near-infrared photons (750 nm to 1260 nm) and/or telecommunication photons (1260 nm to 1675 nm) entangled with photons from one or more quantum sources to an operating wavelength of the optical device (e.g., PIC), programmable routing and entanglement distribution, and scalable long-distance quantum networks.
Provided are compositions and methods for treatment of snakebites. The compositions include a metalloproteinase inhibitor. The compositions can further include one or more antibodies or antigen fragments thereof that bind to components of snake venom. The compositions are administered to an individual who has been envonmated by a snake to thereby reduce damage caused by the envonmation.
A structure can comprise a substrate and a composite coating. The composite coating can be formed over a surface of the substrate. The composite coating can include one or more nanoparticles within an oxide matrix. The nanoparticles can be formed of a temperature-dependent Mott insulator having a phase transition temperature. At a temperature below the phase transition temperature, the composite coating can transmit light in a first wavelength range, and at a temperature above the phase transition temperature, the composite coating can block light in the first wavelength range. For example, the structure can be used as a smart 10 window to help regulate heating of building interiors due to solar radiation. The composite coating can be formed via a short-duration, high-temperature heating pulse, for example, at least 1500 K for less than 60 seconds.
A system for differentiable analog quantum computingincludes a a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the system to obtain an optimization problem represented by a time-dependent Hamiltonian, wherein the time-dependent Hamiltonian includes a trainable variable v; generate a loss function based on the time-dependent Hamiltonian; perform a differentiation of the loss function with respect to the trainable variable v for the time-dependent Hamiltonian; minimize the loss function to update the trainable variable v; and generate a control signal for a quantum device based on updating the trainable variable v.
This present disclosure is directed to electrolyte compositions for Li-ion batteries, the preparation of said batteries, and uses thereof. Examples of electrolyte compositions disclosed herein allow for Li-ion battery use in extreme operating conditions over a wide temperature range, allowing for efficient use at both high and low temperatures.
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
H01M 10/0561 - Accumulators with non-aqueous electrolyte characterised by the materials used as electrolytes, e.g. mixed inorganic/organic electrolytes the electrolyte being constituted of inorganic materials only
77.
High temperature sintering furnace systems and methods
A sintering furnace can have a housing, one or more heating elements, and a conveying assembly. Each heating element can be disposed within the housing and can subject a heating zone to a thermal shock temperature profile. A substrate with one or more precursors thereon can be moved by the conveying assembly through an inlet of the housing to the heating zone, where it is subjected to a first temperature of at least 500° C. for a first time period. The conveying assembly can then move the substrate with one or more sintered materials thereon from the heating zone and through an outlet of the housing.
F27B 9/06 - Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity electrically heated
F27B 1/22 - Arrangements of heat-exchange apparatus
F27B 9/02 - Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity of multiple-chamber type; Combinations of furnaces
F27B 9/12 - Furnaces through which the charge is moved mechanically, e.g. of tunnel type; Similar furnaces in which the charge moves by gravity with special arrangements for preheating or cooling the charge
78.
RADIATIVE COOLING COMPOSITIONS, PRECURSORS FOR FORMING THE COMPOSITIONS, AND COATINGS FORMED FROM THE COMPOSITIONS
Radiative cooling compositions, as well as precursors for forming such compositions, are disclosed. The compositions comprise solid particles of at least a first composition (e.g., Al2O3), which are bound by a suitable binder (matrix or framework). During the synthesis of these compositions from a precursor, solvent of a binder-forming liquid such as water glass may be evaporated, or otherwise glass (e.g., mixed oxide) particles in the precursor may be softened and/or melted, in either case providing a binder for the solid particles. The manipulation of composition porosity, impacting mechanical strength, as well as performance characteristics (reflectance and/or emissivity), is possible through the selection of types and amounts of components, such that a suitable combination of properties can be engineered without the need for polymers or other materials that may be detrimental in terms of cost and/or stability.
An antimicrobial material can include one or more fibers and a plurality of metal ions. Each fiber can have a plurality of cellulose molecular chains with functions groups. The metal ions can be impregnated within the one or more fibers such that each metal ion forms a coordination bond between functional groups of adjacent cellulose molecular chains. The one or more fibers can exhibit a cellulose-I lattice structure. In some examples, the antimicrobial material is provided as a surface layer in or on a substrate.
Aspects of the present disclosure describe a method including predicting a first set of ansatz terms and a first plurality of amplitudes associated with the first set of ansatz terms; minimizing energy of the system based on the first set of ansatz terms and the first plurality of amplitudes; computing perturbative corrections using one or more ansatz wavefunctions; determining whether energy of the system converges; and predicting, in response to determining that the energy of the system does not converge, a second set of ansatz terms and a second plurality of amplitudes associated with the second set of ansatz terms.
A vacuum-insulated structure can have one or more internal cells, one or more foam cores, and an enveloping structure. Each foam core can be formed from a plant material. Each foam core can be disposed within a respective one of the cells. The enveloping structure can seal each foam core within the respective cell at a pressure less than atmospheric pressure.
B32B 5/18 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer containing foamed or specifically porous material
82.
ULTRAFAST HIGH TEMPERATURE SINTERING (UHS) SYSTEMS AND METHODS FOR FABRICATING ENVIRONMENTAL-THERMAL BARRIER COATINGS
One or more precursors can be provided over a surface of a component. A heating element can be provided over the one or more precursors such that the heating element substantially conforms to a shape of the component surface. The precursor(s) can be sintered to form a layer of an environmental-thermal barrier (ETB) coating by subjecting the precursor(s) to a temperature of 500-3273 K for a duration of 10 minutes or less. The temperature can be generated by passing an electric current through the heating element to cause Joule heating of the heating element.
C23C 4/02 - Pretreatment of the material to be coated, e.g. for coating on selected surface areas
C23C 4/12 - Coating by spraying the coating material in the molten state, e.g. by flame, plasma or electric discharge characterised by the method of spraying
C23C 24/08 - Coating starting from inorganic powder by application of heat or pressure and heat
83.
RADIATIVE COOLING COMPOSITIONS, PRECURSORS FOR FORMING THE COMPOSITIONS, AND COATINGS FORMED FROM THE COMPOSITIONS
e.g.23e.g.e.g., mixed oxide) particles in the precursor may be softened and/or melted, in either case providing a binder for the solid particles. The manipulation of composition porosity, impacting mechanical strength, as well as performance characteristics (reflectance and/or emissivity), is possible through the selection of types and amounts of components, such that a suitable combination of properties can be engineered without the need for polymers or other materials that may be detrimental in terms of cost and/or stability.
Precursor metal salts of at least two different metals can be loaded onto a substrate. The substrate can be heated at a heating rate to a first temperature, and then maintained at the first temperature for a first time. The first temperature can be in a range of 1000-3000 K, and the first time can be in a range of 1 μs-10 s. After the first time, the substrate can be cooled from the first temperature at a cooling rate, such that a metallic glass material is formed on the substrate. The metallic glass material can comprise a homogeneous mixture of the at least two different metals and forming a single amorphous solid.
Geophysical anomalies in an area or region can be detected, characterized, or otherwise mapped using a combination of environmental and geophysical sensor data acquired using a vehicle, which may be a remotely operated or autonomously controlled unmanned vehicle. Anomalies are detected by processing the environmental sensor data and geophysical sensor data using artificial intelligence algorithms, programs, or models. As an example, the artificial intelligence algorithms, programs, or models can include machine learning algorithms, programs, or models. The environmental sensor data are processed to generate control parameters for controlling the acquisition and/or processing of the geophysical sensor data optimized for environmental conditions in the area.
A system for the evaluation of respirator materials includes an aerosolized particle source configured to selectively provide aerosolized particles, a mixing chamber including a drying apparatus, a vacuum source configured to control airflow, an airtight respirator chamber for evaluating respirator materials, a processor, and a memory. The airtight respirator chamber includes a first sub-chamber, a second sub-chamber, a first sensor and a second sensor. The memory includes instructions stored thereon, which when executed by the processor cause the system to: obtain the first signal and the second signal; determine an aerosol filtration efficiency based on a difference between the first signal and second signal; compare the aerosol filtration efficiency to a predetermined threshold; and provide an indication whether the aerosol filtration efficiency is above or below the predetermined threshold.
Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
88.
ELECTRORESPONSIVE BIOPOLYMER CAPSULES FOR ELECTRICALLY MEDIATED DELIVERY OF ACTIVES
Surprisingly, electric fields can induce a dramatic response in soft materials made from nonconducting biopolymers. Capsules made from Alginate, Chitosan, and Gellan gum, all of which are charged polysaccharides and are biocompatible and biodegradable. Each capsule is formed by crosslinking biopolymer chains via physical (ionic/electrostatic) interactions. Under a DC electric field, the capsules rupture and disintegrate in a span of less than five minutes. The mechanism for the electroresponse is attributed to electrophoretic rearrangement of ions and/or polyelectrolyte chains in the capsule. Alginate capsules first swell anisotropically on their side closer to the anode (+ electrode). Cations migrate away from the anode, thereby lowering the crosslink density on that side. As further crosslinks are lost from the anode side, the capsule eventually breaks. A valve design utilizes an orifice that is blocked by a capsule and the valve is opened when the capsule is dislodged by the field.
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/36 - Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
The present invention provides polypeptides, and polypeptide dimers, comprising a modified flavivirus envelope E polypeptide, wherein the modified flavivirus envelope E polypeptide comprises i) a cysteine residue in a fusion loop epitope of ectodomain DII; and ii) a cysteine residue in ectodomain DI located in an N-terminal portion of the polypeptide, nucleic acids, vectors, host cells, and pharmaceutical compositions comprising the same, and methods of inducing an immune response in subjects by administering the pharmaceutical compositions of the invention.
Examples of the present disclosure provide systems and methods for performing quantum simulation. For example, such systems and methods may perform quantum simulation, at least in part, by obtaining a Hamiltonian equation and a selection of a target quantum device, accessing an abstract analog instruction set configured to cause an evolution in the selected target quantum device, and compiling the Hamiltonian equation to generate a pulse schedule based on the abstract analog instruction set for the target quantum device.
The present disclosure relates to photo-immunoconjugate formulations comprising a nanoparticle carrier comprising first and second therapeutic agents coupled to the nanoparticle carrier, and a photosensitizer molecule coupled to the first therapeutic agent or the nanoparticle carrier, and methods of treating cancer via administration of the photo-immunoconjugate formulations.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
92.
HIGH VOLTAGE AQUEOUS ELECTROLYTE SYSTEM FOR LITHIUM METAL OR GRAPHITE ANODE
The United States of America as Represented by the Secretary of the Army (USA)
Inventor
Xu, Kang
Wang, Chunsheng
Yang, Chongyin
Abstract
The present invention is directed to aqueous solid state electrolytes that comprise a fluoride additive to stabilize the interface between the anode and aqueous electrolyte. The present invention is also directed to methods of making the solid state electrolyte materials and methods of using the solid state electrolyte materials in batteries and other electrochemical technologies.
H01M 10/0567 - Liquid materials characterised by the additives
H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/134 - Electrodes based on metals, Si or alloys
H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx
Disclosed herein are methods of producing glyco-modified viral antigens that provide a shift of the glycosylation profile of recombinant produced viral antigens (e.g. glycoproteins) towards the naturally occurring viral antigens (e.g. glycoproteins). Disclosed are methods of producing a modified viral antigen comprising expressing a viral antigen in a recombinant mammalian cell line having one or more of the endogenous genes Mgat2, Mgat4A, Mgat4B, Mgat5, St3Gal3, St3Gal4, B4galt1, B4galt2, B4galt3, B4galt4, B4galt5, B3gnt2, St3Gal6, SPPL3, and/or FUT8 inactivated and/or downregulated; and optionally a gene ST6Gall inserted. Disclosed are glyco-modified viral antigens produced by the method of using a recombinant mammalian cell line. Disclosed are methods of treating a subject in need thereof comprising administering a composition comprising a therapeutically effective amount of one or more of the glyco-modified viral antigens. Disclosed are methods of screening for an antibody specific to one or more of the disclosed glyco-modified viral antigens.
A plurality of Brillouin spectroscopy measurements can be obtained for different measurement points with respect to a patient's eye. The locations of the respective measurement points and/or the patient's eye can be tracked in three-dimensions by one or more optical modalities. Based on the tracking, each Brillouin spectroscopy measurement can be assigned to a particular lateral location and depth with respect to or within the patient's eye. A Brillouin reading can be determined for each lateral location using the Brillouin spectroscopy measurements assigned to the respective lateral location but at different depths. One or more metrics can be calculated based at least in part on the determined Brillouin readings. A determination of whether the patient's eye exhibits subclinical keratoconus can be made based at least in part on the one or more metrics.
A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
A61B 3/103 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining refraction, e.g. refractometers, skiascopes
A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
In a first stage of a methane conversion system, at least some methane (CH4) in an input gas flow stream can be converted into C2 hydrocarbons, hydrogen gas (H2), and aromatics to provide a first processed stream. The conversion can be direct non-oxidative methane conversion (DNMC). At least some of the aromatics can be removed from the first processed stream to provide a second processed stream. In a second stage of the methane conversion system, at least some of the H2 can be removed from the second processed stream to provide a recycle stream. The recycle stream can be returned to the first stage of the methane conversion system for further conversion of methane and removal of aromatics and H2 products.
C07C 2/84 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation of hydrocarbons with partial elimination of hydrogen oxidative coupling catalytic
B01J 10/00 - Chemical processes in general for reacting liquid with gaseous media other than in the presence of solid particles; Apparatus specially adapted therefor
B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
B01J 19/18 - Stationary reactors having moving elements inside
A system includes a trapped ion, a single-photon source, or a quantum emitter configured to emit a first entangled photon and a plurality of quantum frequency conversion stages configured to convert the first entangled photon to a telecommunication photon (1260 nm to 1675 nm). Each quantum frequency conversion stage includes a corresponding pump laser, configured to interact with an incoming photon, that creates an output photon having a frequency that is at least 12 THz higher than a frequency of the pump laser, such that each quantum frequency conversion stage has a signal-to-noise ratio (SNR) of at least 1. Advantageously the system can provide an ultra-low noise quantum frequency conversion scheme to generate telecommunication photons (1260 nm to 1675 nm) entangled with photons from a quantum source (e.g., trapped ion, single-photon source, quantum emitter), a high signal integrity, and scalable long-distance telecommunication quantum networks.
A piece of natural fibrous plant material, such as wood or bamboo, can be infiltrated with a chemical solution and subsequently subjected to a temperature of at least 80° C. to produce a softened piece of fibrous plant material having modified lignin therein. The content of modified lignin in the softened piece can be at least 90% of the content of native lignin in the natural fibrous plant material. The modified lignin retained in the softened piece can have shorter macromolecular chains than that of the native lignin. The softened piece can be subjected to densification, for example, to yield a high-strength structural material, or to subsequent drying, for example, to yield a flexible or anisotropically-clastic material. The processing of the natural fibrous plant material can avoid, or at least reduce, the production of black liquor or other waste liquids.
An axial field rotary energy device can include a housing and a rotor rotatably coupled to the housing. The rotor can have an axis of rotation and magnets. A stator assembly can be coupled to the housing coaxial with and adjacent to the rotor. The stator assembly can include a printed circuit board (PCB) having electrically conductive coils and an internal air duct for cooling the stator assembly.
H02K 3/24 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors with channels or ducts for cooling medium between the conductors
H02K 3/26 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors consisting of printed conductors
H02K 9/06 - Arrangements for cooling or ventilating by ambient air flowing through the machine having means for generating a flow of cooling medium with fans or impellers driven by the machine shaft
99.
STRENGTH-ENHANCED ENGINEERED STRUCTURAL MATERIALS, AND METHODS FOR FABRICATION AND USE THEREOF
An engineered structure can comprise a first laminate having a plurality of constituent plant material layers. The plurality of constituent plant material layers can comprise one or more first layers and one or more second layers. Each plant material layer can be adhered to an adjacent plant material layer via glue. Each first layer can be a densified plant material layer having a density greater than or equal to 1.15 g/cm3and a first mechanical strength. Each second layer can be a plant material layer having a density less than 1.15 g/cm3 and a second mechanical strength less than the first mechanical strength. For example, the plant material of each layer may be wood or bamboo.
B27D 1/04 - Joining wood veneer with any material; Forming articles thereby; Preparatory processing of surfaces to be joined, e.g. scoring to produce plywood or articles made therefrom; Plywood sheets
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 21/04 - Layered products essentially comprising wood, e.g. wood board, veneer, wood particle board comprising wood as the main or only constituent of a layer, next to another layer of a specific substance
B32B 21/13 - Layered products essentially comprising wood, e.g. wood board, veneer, wood particle board all layers being exclusively wood
E04C 3/14 - Joists; Girders, trusses, or truss-like structures, e.g. prefabricated; Lintels; Transoms of wood, e.g. with reinforcements, with tensioning members with substantially solid, i.e. unapertured, web
100.
METHODS AND PLATFORMS FOR ELICITING AN IMMUNE RESPONSE IN THE TREATMENT OF CANCER AND COMPOSITIONS AND VACCINES RELATING THERETO
The present disclosure relates to methods for eliciting an immune response to a cancer antigen in a subject in need thereof by introducing directly into at least one lymph node of the subject, and preferably at least two lymph nodes, a therapeutically effective amount of a cancer antigen and/or an adjuvant such that an immune response to the cancer antigen is activated or enhanced in the subject. The present disclosure also concerns pharmaceutical compositions that comprise a therapeutically effective amount of a cancer antigen and/or an adjuvant capable of mediating, and more preferably enhancing, activation of the immune system of a subject against cancer cells that are associated with any of a variety of cancers. The disclosure also relates to the use of such pharmaceutical compositions in the treatment or prevention of a cancer in a recipient subject.
